otolena

KOTOLENA AT A GLANCE

KEY TECHNOLOGY

Our Top of the line products are developed for aging prevention and anti-aging. We have 3 groups of products that suites woman's needs for all the ages starting from 25 years. Our key ingredients are KotoneocinTM and Matrikine peptides.

KOTONEOCIN

KotoneocinTM Technology is developed by our scientific team specifically to address the problem of preventing skins aging. It is not a secret that at young ages aging cascades begin to roll out on the cellular level. The thinning of aging skin occurs at the rate of about 6% every 10 years. Depending on many factors such as genetics, visible results of those processes such as small wrinkles may be seen at young ages and become obvious by 30-35. We have developed a unique formulation based on scientific interactions of natural ingredients and potentiation effects. Thoroughly chosen concentration of the active ingredients are those tested to be most effective. KotoneocinTM formulated to work in harmony with the skin's metabolism. This technology can make a difference in slowing the signs of aging and preserving the skin's beauty. y Fewer new lines and wrinkles appear as felt by 79% woman in 5 weeks. y Skin feels healthy, hydrate and radiant as felt by 84% woman in 5 weeks.

MATRIKINE PEPTIDES

Matrikine peptides are matrix derived peptides that regulates the wound healing and tissue remodeling activity. These short chains of amino acids play an important role in tissue repair activity via the stimulation of collagen synthesis.

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Renewing collagen is a key process in skin care and in the reduction of wrinkles. Different medical studies were made to see how effective this peptide could be. This particular double-blind, randomized, controlled clinical study with 3D imaging proved that some peptides, namely Pal-KT and Pal-KTTKS, can significantly improve crow's feet smoothness after 4 weeks in comparison to the control group. In other recent clinical studies it was identified that matrikine peptide (C16-KTTKS) can stimulate collagen production to a level higher than controls on the 3rd day of application. Many more research papers were published in prestigious medical scientific journals presenting more data on matrikine peptides' efficacy in skin repair. Matrikine peptides as the cosmetology ingredients have recently demonstrated

COMPANY FACTS

great results in repairing photo-aged skin and the defragmented collagen network at dermis level. This product underwent extensive research for efficacy and safety. The wrinkles of crow's feet decrease by 33% after applying a cream with Matrikine peptides for two months.* In mid-2011, Sederma presented a new in vivo test demonstrating Matrikine peptides' ability to help repair the UV damage-prone papillary dermis caused by photo-induced aging. Papillary fibroblasts are fundamental to promote epidermal morphogenesis and wound healing, which is why papillary dermis repair delivers visible anti-wrinkle benefits.* In 2013, a complementary approach has confirmed Matrikine peptides' repairing effect on the cutaneous damages of aging, where its ability to reverse chronological aging has been

OUR PHYLOSOPHY Kotolena was founded by a group of medical doctors. We were not satisfied with current cosmetic products in many ways, thus we partnered with medical scientists and experienced chemists with extensive expertise in cosmetics. First we developed a low allergenic and calming base for sensitive and irritated skin for further development of future products. As a next step we focused on modern medical scientific approaches for the problem of skin aging and acne treatment. Results of our collaborative work can be found among Kotolena products. We are continuing our studies and more great products are to be introduced in the future.

The magnificent forests of Canada are truly nature's wonder. Being a local cradle for biodiversity since the last Ice Age, they are the keepers of many secrets yet to be revealed. Maintaining the nature in balance for ages, their life energy is endless. The beauty resources that Kotolena offers you are taken from powerful Canadian nature, from the heart of the plant king, their vital systems that produce essential energies. Our unique approach combines scientific knowledge of plant energies with a deep understanding of the vital energies of the human body, acquired through more than 35 years of scientific and medical background.

KOTOLENA AT A GLANCE

demonstrated with both in vitro and ex vivo studies. Matrikine peptides have notably been shown to regulate the expression of well-known (SA ~-galactosidase) and recently discovered (progerin) markers of senescence.* In vivo studies have revealed the positive matrix reinforcing effect of Matrikine peptides by measuring the SLEB density (Subepidermal Low Echogenic Band that corresponds to the papillary dermis). A significant improvement corresponding to a gain in age of

the papillary dermal fibre network.*

EDT SYSTEM Enforced Transdermal Delivery System (EDT) - at the normal skin temperature active molecules of key ingredients interact quickly with water and fat of hydrolipid film of epidermis and penetrate to deep layers of the skin. Due to Hi-Tech ETD System and ease of use

MODERN SCIENTIFIC BASED INGREDIENTS

RICH OF NATURAL OILS AND EXTRACTS

INNOVATIVE DELIVERY SYSTEM

based on the rigorous selection of natural ingredients, careful proportioning and exclusive blends of active extracts and natural cosmetic oils, resulting in effective antiaging skincare effect. Using a holistic approach our medical team combined the power of Canadian Nature and Hi-Tech and innovative components -famous Matrikine peptides, Kotoneocyn

™, Miracle Repair (Anti-Aging Complex), Ubiquinone, Hyaluronic Acid, Hydrolyzed Collagen. We use only ingredients which have affinity with the skin. 1.8 years is visible in just one

month, and after 2 months, photo-induced aging is then delayed by 5.5 years.*

MEDICAL DOCTORS' FORMULATED OUTSTANDING CANADIAN QUALITY

Another analysis of the papillary dermis by confocal laser microscopy has shown that Matrikine peptides help reduce the fibre fragmentation and notably supports the reconstruction of

the Premium Collagen Excellence Mask provides immediate visible effect.

We offer unique skincare products

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We develop our products to meet the high expectations of people with problematic skin. That means that KotolenaTM products are also expected to be very good for the majority of people without significant issues. We use ingredients only from the US, Canada and EU. We use Certified natural oils in our products. Our products comply with Top industry requirements: V free of irritating ingredients -...( free of parabens -...( free of sulphates -...( free of dyes -...( free of dimethylaminoethanol (DMAE) V. free of triethanolamine (TEA) \f free of artificial fragrances -...( free of mineral oils -...( not tested on animals -...( phthalate free -...( non toxic formula -...( non-acnegenic

*Information on Matrikine peptides, claims, their composition and efficacy claims are taken from official sources of Sederma SAS. In case of any wrong or fault claims, other scientific or legal issues KOTOLENA Pharmaceutical and Cosmetics Corp. will not be kept responsible for those claims.

KOTOLENA PRODUCTS

Targeted formulation for every age Our doctors formulated skin mosturizers SP.ecifically to meet requirements of every age and all the skin types.

• kotolena LTIMATE ANTI-AGE

COMPLEX ClI!iL\ - I .1 !-··•

ULTIMATE REGENERATION CREAM

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Kotoneocin™ Moisturizing Cream

Concerns: first wrinkles premature aging

stressed and fatigue skin ••• O all skin types ·.•: L

Benefits: - helps prevent premature skin aging - helps reduce the appearance of fine line and wrinkles - rejuvenates and soothes stressed skin - helps enhance collagen production - hydrates and nourishes skin to optimal level - infuses the skin with powerful antioxidants - helps decrease UVA radiation damages from oxidative stress - improves skin texture and elasticity - helps strengthen skin immunity

Anti-aging Matrikine Peptides Complex

Concerns: fine lines and wrinkles uneven skin tone

dehydrated skin dull and lifeless skin all skin types

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Benefits: - helps reduce the appearance of fine lines and wrinkles - boosts skin elasticity - helps enhance collagen synthesis - strengthens the skin's protective membranes and barriers - increases skin hydration to leave skin soft and glowing - helps protect the skin from harmful UVA/UVB sun rays - works to correct hyperpigmentation and even skin tone - helps improve blood microcirculation - restores skin vitality

Ultimate Anti-Age Complex with Hyaluronic acid

Concerns: deep lines and wrinkles uneven skin tone

dehydrated skin dull and lifeless skin all skin types

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Benefits: - increased Matrikine Peptides concentration - helps reduce the appearance of deep lines and wrinkles - maximizes regeneration and skin hydration - boosts skin elasticity - helps enhance collagen synthesis - strengthens the skin's protective membranes and barriers - helps protect the skin from harmful UVA/UVB sun rays - works to correct hyperpigmentation and even skin tone - helps improve blood microcirculation - restores skin vitality

KOTOLENA PRODUCTS

Targeted formulation for every age Our doctors formulated skin mosturizers SP.ecifically to meet requirements of every age and all the skin types.

Ill kotolena ULLTRA BRIGHTENINMG

UMINIZER CREA / SKIN TONE CORRECTION

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Additional formulations

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Ultra Brightening Luminizer Cream

Concerns: first wrinkles premature aging

stressed and fatigue skin ••• O all skin types ·.•: L

Benefits: - dark spots correction - color correction - evens skin tone

Anti-Age Matrikine Peptides Serum

Concerns: fine lines and wrinkles uneven skin tone loss of face oval

dehydrated skin dull and lifeless skin all skin types

Benefits: - rejuvenates and soothes aging skin - decreases the appearance of fine lines and wrinkles

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- helps rebuild cell tissue and stimulate collagen biosynthesis - improves firmness and elasticity of the skin - strengthens skin immunity - restores skin texture

Anti-~uffy Eyes and Bags Gel

Harmonizing Toner

Anti-aging Matrikine Peptides Eye Cream

Ultra-comfort Energizing Toner

Foaming Cleanser with AHA

Mattifying Anti-Acne Toner with AHA

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