Knowing Where & Getting There: A Human Navigation Network
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Knowing Where & Getting There: A Human Navigation Network
Eleanor A. Maguire et al.
Group B8: Enakshi Singh, Meinas Elmusharaf, Adam Ouellette, Seung Na & Safiah Mai
To be presented by: Enakshi & Safiah
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OutlineEnakshi
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Background
Hippocampal formation
Place cells & head direction cells in rats
Allocentric representations
Posterior parietal lobe
Egocentric representations
Enakshi
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Purpose
To investigate the neural basis of navigation in humans by studying the role of the hippocampus in human navigation
Enakshi
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Experimental Methods
10 subjects Familiarized to virtual reality town
Internal representation
Fig 1A
Enakshi
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Experimental Methods
Nav1:
subjects move directly toward the destination
Nav2:
subjects must take detour to get to the destination
Enakshi
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Virtual Reality Town
Fig 2A
Nav1 - yellow direct route A - B
Nav2 - green detour A – B
lost – red A – no mans land
Enakshi
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Experimental Methods
Arrow-task:
subjects follow a trail of arrows to destination
Static-scenes:
subjects identify static scenes from town
Enakshi
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Experimental Methods
Positron Emission Tomography (PET) to visualize activated areas in the
brain
Enakshi
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Experimental Methods
Investigate which brain regions were involved in successful navigation in both nav1 and nav2
Explore relationship between regional cerebral blood flow (rCBF) and behaviour during nav1
Enakshi
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Quantitative Results
Nav1 (direct)
22/30 successes
Nav2 (detour)
21/30 successes
Safiah
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Neuroimaging Results
Successful trials
Right hippocampus
Unsuccessful trials
Left hippocampus
Left frontal and lateral temporal cortex
Thalamus
Safiah
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Results and Interpretation 1
Imaging of successful trials
Fig 1B
Safiah
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Results and Interpretation 2
Fig 2B,C
Safiah
ACCURACY OF DIRECTION
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Results and Interpretation 2 Right Hippocampus
Allocentric representation of space
Start to destination
Right Inferior Parietal Cortex Egocentric aspects of movement
Enables movement around objects toward goal
Safiah
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Results and Interpretation 3
Fig 3A
Safiah
NAV2 VS NAV1: LEFT MIDDLE AND SUPERIOR FRONTAL GYRI AND RIGHT CEREBELLUM
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Results and Interpretation 3
Left Middle and Superior Frontal Gyri
Planning and decision making
Safiah
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Results and Interpretation 4
Fig 3B
Safiah
SUBTRACTING STATIC CONDITION: RIGHT INFERIOR PARIETAL CORTEX + BILATERAL MEDIAL TEMPORAL CORTEX
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Results and Interpretation 5
Fig 3D Fig 3C
Right caudate nucleus
Safiah
SPEED OF NAVIGATION: RIGHT CAUDATE NUCLEUS
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Summary of Results
Active Areas during successful trials
Arrow task - R. hippocampus
Unsuccessful
- L. hippocampus
- L. lateral temporal cortex
- L. frontal cortex
- thalamus
Active areas:
Successful trials vs. Arrow-task and Unsuccessful trials
Safiah
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Summary of Results
nav1 nav 2
Shown activity
- R. Hippocampus- R. inferior parietal cortex
- L. Frontal activation
Speed of navigation
- R. Caudate nucleus
---
rCBF shown activity during nav1 and nav2
Safiah
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Main Conclusions
Results agree with previous findings: lesions in right hippocampus spatial
memory defects
rCBF in R. caudate nucleus is correlated with navigation speed
motor learning and context recognition
Enakshi
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Main Conclusions
Parietal role in monkeys
Humans vs. Rats Hippocampus
Enakshi
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References Maguire, E.A., Burgess, N.M., Donnett, J.G.,
Frackowiak, R.S., Frith, C.D., & O’Keefe, J. (1998). Knowing where and getting there: a human navigation network. Science, 280, 921-924.
Wiener, S.I. (1993). Neurobiological Learning Memory. Journal of Neuroscience, 13, 3802.
Kinsbourne, M., Wood, F. (1975). Short-Term Memory. Science, 257-291.