(KGMU DHR-MRU)

www.kgmudhrmru.in

Prof Divya MehrotraNodal OfficerDHR-MRU

King George’s Medical Universitydivyamehrotra@hotmail.com

kgmudhrmru@gmail.com09395902322

KING GEORGE’S MEDICAL UNIVERSITY

MULTI DISCIPLINARY RESEARCH UNIT

Name & Address of Medical College

King George’s Medical University

Shamina Road, Chowk

Lucknow

Uttar PradeshName, Phone No. E-mail id of Principal

Prof. M L B Bhatt

Vice Chalcellor

vc@kgmcindia.edu

Name, Phone No. E-mail id of Nodal officer

Prof. Divya Mehrotra

9335902322

divyamehrotra@hotmail.com

B. Physical Parameters of

Performance

MoA was signed and submitted to the Department of HealthResearch, NewDelhi.

The amended MoAwas signed by Vice Chancellor, KingGeorge’s Medical University, Lucknowand submitted toDepartment of Medical Education, Government of UttarPradesh for signature of the competent authority and wouldbe submitted to Department of Health Research as wereceive it back.

Signing of MoA

The building space was allocated by the Universityadministration in 2016. Civil work was completed in 2016.

Additional space was allocated to MRU

Renovation and civil work was included under the tenderadvertised for second year purchase of equipment.

Allocation of Building/space for establishing

the MRU

Building layouts/maps

82ft x 28 ft=2296 sq ft

Building layouts/maps

To be renovated in second year grant=625 sq ft

S.N Name of Equipment 1. Gel Documentation System2. Elisa Reader3. Elisa Washer4. CO2 Incubator5. Biosafety Cabinet6. Thermocycler (PCR)7. Cell Counter 8. Refrigerated Micro-centrifuge9. Electrophoresis 10. Table Top Mini Centrifuge11. Table Top Refrigerated Centrifuge

12. –800C Freezer13. Liquid Nitrogen Container14. Water Purification

Tendering and Procurement of equipment

under the scheme

S.N Name of Equipment 15. Nano drop16. Inverted Microscope17. Analytical Balance18. pH Meter19. Micropipette Kits20. Vortex Mixture21. Magnetic Stirrer22. Serological Water Bath23. Hot Air Oven24. Microwave Oven25. Tissue Homogenizer26. Laboratory Refrigerator27. Laboratory Refrigerator28. Computer System

Tendering and Procurement of equipment

from second year grant

Real Time PCR with Thermo-cyclerCapillary Gene Sequencer Fluorescent Microscope with built-in monitor and software Flow cytometer Microscope (Binocular-light)Microscope (Inverted)Microscope (Fluorescent)Microscope (Trinocular)Liquid nitrogen tankGel DryerBone tissue homogeniserIce flaking machineCold roomAutoclave

Appointment of contractual staff for manning

the positions in MRU

Post Joining date

Research Scientist II 1st January 2018Research Scientist I 1st January 2018Lab Technician 1

stApril 2018

Lab Attendant/ data operator 15th May 2018

C. Research Parameters

Constitution of Local Research Advisory

Committee (LRAC)

Name Chairperson/Member

Designation External/Internal

Institute

Dr Alok Dhawan Chairman Director External IITR, LucknowDr MM Godbole Co-Chairman Ex-Professor and

HeadExternal Department of Endocrinology,

SGPGI, LucknowDr Nuzhat Husain

Member Professor & Head External Department of Pathology, RMLIMS, Lucknow

Dr RK Garg Member Dean Research Internal KGMU, LucknowDr Mohd. Kaleem Ahmad

Member Associate Professor Internal Department of Biochemistry, KGMU, Lucknow

Dr VP Singh ICMR Nominee Scientist D External DHR, New DelhiDr KK Gupta Nominee of State

Health DepartmentDirector General Medical Education

External Director General Medical Education, Uttar Pradesh

Prof Divya Mehrotra

Member Secretary Nodal Officer DHR-MRU, KGMU, Lucknow

Status of meetings of LRACFrequency of meeting

2 meetings were organized in the year 2018, Next meeting is scheduled in Feb 2019Agenda discussed:a. Evaluation of Research Projects b. Purchase of equipment from the second year grant

Participation of External Experts

Dr Nuzahat HussainProfessor and Head Department of Pathology RMLIMS,Lucknow

Visit of Eminent Scientist/ Faculty at MRUDr Soumya Swaminathan, Ex DG ICMR and Secretary DHRProf CL Khetrapal, Eminent Scientist and Founder Director CBMR, LucknowProf Mahesh Verma, Director Maulana Azad Institute of Dental Sciences, New DelhiProf D S Katti, Head Dept of BSBE, IIT KanpurProf. C M Pandey, Head Dept. of Biostatistics and Health Informatics, SGPGI Prof Pradeep Srivastava, Dept of Biengineering, IIT BHUDr A K Saxena, Ex Principal Scientist and Head, IIIM JammuDr Sanjeev Mahto, Dept. of Biomedical Engineering, IIT BHUDr Ramesh Sharma, CDRI, LucknowProf Sandeep Kumar, Ex-Director AIIMS BhopalDr Himanshu Aeran, Director Seema Dental College and Hospital Dr Sachin Rai, PGI Chandigarh

Dr Ved Singh ScientistDHR, New Delhi

Dr Sharad SharmaPrincipal Scientist and Head Toxicology Division CDRI Lucknow

Dr K K GuptaDirector General Medical EducationGovt of Uttar Pradesh

Commencement of work and present status of execution of Research Projects

recommended by LRACResearch Projects Approved by the LRAC 9 Research projects were approved out of 17

(from the grant received under consumables)

Research work started in April 2018, the first year report from the PIs would be submitted by March 2019 and shall be evaluated in April 2019 by the LRAC

Facility Established a. Basic Genomics facility b. Cell Culture facility

Workshops Organized 4 workshops were organizeda. Hands on workshop on Molecular biology techniques: 4th -5th

October 2017b. Workshop on Flow cytometry: 20th Dec 2017c. Swachtha Pakhwara Celebrations- 12th April 2018d. Training on QS3 PCR system: 28th August 2018e. Cell Culture –Skill course 3rd -5th Dec 2018

Conferences Organized 1 National conference on Medical Tissue Bioengineering: 7th-8th September 2018

Training Program 15 days summer school and winter school program would be started from the next year was approved by the LRAC

Training of UG and PG students of University and affiliated colleges: Last Saturday of every month

Commencement of work and present status of execution of Research Projects recommended by LRAC

Research Projects under progress at DHR-MRU KGMU

1. Role of Immuno histochemical methods in mutational analysis of Thyroid Neoplasm

Dr. Chanchal Rana,Assistant ProfessorDepartment of Pathology, KGMU

2. A study on Expression pattern of retinoid acid pathway regulators ALDH1A2, CRABP2 and RARβ in different histopathologicalgrades of leukoplakia & oral submucous fibrosis.

Dr. Rahul Pandey, Research Scientist IDHR MRU, KGMU

3. A study on potential use of different dental/oral sources of human DNAin forensic odontology examinations for victim/suspect identification

Dr Shaleen Chandra, Professor, Department of Oral Pathology, KGMU

4. To study the role of C4d as a diagnostic and prognostic marker in proliferative glomerulonephritis.

Dr. Varsha Kumar, Assistant Professor Department of Pathology, MLN Medical College, Allahabad

5. Analysis of CCN family proteins as diagnostic /prognostic markers and their correlation with primary osteosarcoma patients treatment response

Dr. Dilutpal Sharma, Associate Professor Department of Biochemistry, KGMU

6. Effect Of Non Modifiable Risk Factors On The Expression Of Bone Biomarker And Surgical Periodontal Treatment Outcomes

Dr Rameshwari Singhal, Associate ProfessorDepartment of Periodontology, KGMU

7. Analysis of C677T Polymorphism in the MethylenetetrahydrofolateReductase (MTHFR) Gene as a risk factor for Congenital TalipesEquino Varus (CTEV) : A Case-Parent-Dyad Study

Dr Ajay Singh, ProfessorDepartment of Orthopedics, KGMU

8. Isolation and Characterization of stem cells from Dental pulp, periodontal ligament and apical papilla

Dr Shilpa Trivedi, PhD StudentDepartment of OMFS, KGMU

9. Gene expression study of HOX gene family in Oral Submucousfibrosis, Oral Leukoplakia and Oral Squmous cell carcinoma

Dr Sumit Kumar, Research Scientist II DHR MRU KGMU

New clinical/public health information

generated and presented in National/

International publications

Publications:

Accepted:02Communicated:05Under Preparation:05

Work Presented in conferences/workshop:

1. Workshop conducted by the Research Staff of DHR-MRU KGMU at XVI National Triple “O” Symposium, March 2018.

2. Oral presentation at “ National Biomedical Research Competition held at AIIMS Rishikesh, October 2018

3. Workshop conducted at XXVII conference, Amritsar on quantitative real time PCR techniques and Flowcytometry.

Assessment of Impact on Health Care

Practices and health care Indicators of Project

State/Area

Data collection under process from Costing project funded by DHR, New Delhi.4 projects under taken to evaluate impact of health care practices and indicators

Quality of life assessment for patients with oral pre-cancer and cancer.

Evaluation of Psychological burden in Patients oral pre-cancer and cancer.

Evaluation of health communication on QoL and Psychology of patients counselled and informed of the disease, diagnosis and prognosis.

Evaluation of the Surgical planning in predicting the treatment outcome among patients under going TMJ/Orthognathic/Trauma surgery.

Number of persons imparted training

in research activities

Workshop on Basic Molecular techniques : No. of Participants 50Workshop on Flow Cytometry: No. of Participants 25 Workshop on Q PCR technique: No. of Participants 25Cell Culture Skill Course: No. of Participants 25

Total UG/PG /PhD students trained: 30

Biomedical Tissue engineering Conference : 100 Participants from all over the country

3 Delegates from Cardiff, UK

KGMU DHR-MRU activities planned for

2019 One training workshop planned every 3 months, to conduct 4 training programs

in the year.

Two international conferences planned for April 2019 and September 2019.

KGMU DHR-MRU Summer school and Winter school (15 days training programme) scheduled in May 2019 and Dec 2019.

Second phase extension of the laboratory to be completed by April 2019.

Lecture on cancer prevention on World Cancer day 4th Feb (Monday) 2019. Awareness camp on 31st May 2019, World no tobacco day. Lecture and awareness program on World Heart day 29th September and World Diabetes day on 14th Nov

Planned a 2 day workshop on Ethics to be organized by DHR MRU in association with institutional ethics committee on World Ethics Day 17 October.

Weighing Balance Nano Drop Shaker

Magnetic StirrerWater BathVortx

Water Purification Unit Liquid Nitrogen Tank

Cell CounterMini Spin

Centrifuge Centrifuge

MicroscopeThermal Cycler

Bio-Safety cabinet CO2 Incubator

ELISA Reader Well Washer

Gel Doc pH Meter