Katie Dainty: Research Chair in Patient-Centred Outcomes · science, patient-centred outcome...

Katie Dainty, PhD

Katie Dainty, PhD joined NYGH in September 2017, aided by the dedicated work of the Foundation, as the Research Chair in Patient-Centred Outcomes. Katie is an Assistant Professor at the IHPME at the University of Toronto. She earned her PhD in Critical Qualitative Study of Collaborative ICU Quality Improvement from the Institute of Medical Science at the University of Toronto. She is also appointed to the Program Area of Study Lead — Outcomes & Evaluation at the IHPME. Her work involves studying issues related to patient and family experience, organizational behaviour, implementation science, patient-centred outcome measures and quality improvement in community health care environments. Her current research focuses on the use of qualitative and mixed methods research to critically interrogate held assumptions about behaviour and culture and their impact on how we measure quality and health outcomes. On this subject, her study “Home Visit-Based Community Paramedicine and Its Potential Role in Improving Patient-Centered Primary Care: A Grounded Theory Study and Framework” published in the March issue of Health Services Research was recently highlighted in several media events. Katie’s project “Building Capacity for Patient Engagement & Priority-Setting in Resuscitation Science” was awarded a CIHR Patient-Oriented Research Collaboration Grant. She received the American Heart Association Young Investigator Award and the CIHR Rising Star Award.

Papers: In the January 22nd 2018 issue of the Journal of American Heart Association, Katie Dainty contributed to their meeting highlights entitled “The Latest in Resuscitation Science Research: Highlights from the American Heart Association's 2017 Resuscitation Science Symposium”.

In April 2018, Katie Dainty leading and corresponding author of the study “A Realist Evaluation of Value-Based Care Delivery in Home Care: The Influence of Actors, Autonomy and Accountability” received the news that the study was accepted for publication in the journal “Social, Science & Medicine”. In 2008, the Ministry of Health and Long Term Care in Ontario, Canada launched the Integrated Client Care Project (ICCP), a multi-faceted initiative to increase value by improving outcomes and shifting the home care sector to a bundled reimbursement system. Katie’s team was selected to conduct an independent evaluation of both the implementation and the impact of the ICCP with a view to measuring and understanding the individual components of the program and the way in which they influenced the ultimate outcomes of the project. Katie’s team applied a realist evaluation methodology in order to unpack the influences of contextual and mechanistic choices on the intended outcomes of the ICCP implementation. The schematic below shows the conversion from theory of value to the ICCP “puzzle piece”.

2018 CALENDAR YEAR IN REVIEW

Katie Dainty: Research Chair in Patient-Centred Outcomes

NORTH YORK GENERAL HOSPITAL RESEARCH & INNOVATION 2018-2019 11

Their findings highlight how theoretical mechanisms were negatively impacted by strong contextual patterns and weak implementation which led to underwhelming outcomes. Autonomy of the participant organizations, lack of power within the implementation team to drive change, opacity of the goals of the program, and disregard for the impact of complex historical relations within the home care sector compounded to undermine the intended outcome. In the May 2018 issue of the “Resuscitation” journal, Katie Dainty, co-author of the Editorial “Life after cardiac arrest: The importance of engaging with the ‘forgotten patient’” highlighted that family members and partners’ of out-of-hospital cardiac arrest (OHCA) patients often witness or perform CPR, triggering in them a stressful situation that causes exceptional psychosocial needs, making the caregiver a “forgotten patient”. The analysis of the growing literature on this topic evidences that substantial post-traumatic stress continues in a significant percentage of caregivers even after a year of the event. The authors manifest the need of addressing this concern to better support the survival of the “forgotten patients” in sudden cardiac arrest. Presentations: On May 2nd, 2018, Katie Dainty, was an invited Key Note Speaker for the Canadian Emergency Research Network Annual Meeting, where she presented “Social Science is the new black: How Social Science can enhance the EMS Research Wardrobe”. In Florence, Italy on October 5th, 2018, Katie Dainty was invited by the American Heart Association to speak at their Emergency Cardiac Care Regional Meeting. Her presentation “Cutting Edge Resuscitation Science Overview” explored the present state of resuscitation science and gave an overview of a few of the more important papers which have recently been published to outline the lessons learned. Appointments & Awards: On May 9th, 2018, Katie Dainty was awarded the Institute of Medical Science 2018 Module Director Award for excellence in the development, direction and facilitation of an IMS graduate module from the Institute of Medical Science, University of Toronto.



2018 CALENDAR YEAR IN REVIEW2018 CALENDAR YEAR IN REVIEW


Michelle Greiver, M.D., CCFP, FCFP

Dr. Michelle Greiver is the Gordon F. Cheesbrough Research Chair in Family and Community Medicine (funded by the Foundation) and Director of the University of Toronto Practice-Based Research Network (UTOPIAN) since September 2018. The Chair, named after one of NYGH’s greatest leaders and champions, is the first of its kind in Canada. Dr. Greiver succeeds Dr. Frank Sullivan, the inaugural Cheesbrough Chair. Dr. Greiver is a practicing Family Physician in North York and a Research Scientist in NYGH, she is also an Associate Professor and a Clinician Investigator in the Department of Family and Community Medicine (DFCM) at the University of Toronto; and is an Adjunct Scientist at the Institute for Clinical Evaluative Sciences (ICES). At NYGH, Dr. Greiver initiated and led the development of the Health Databank Collaborative. This project joins primary care Electronic Medical Records (EMRs) and hospital data, enabling research on transitions of care. Dr. Greiver also leads the UTOPIAN team, a network of over 1,400 family physicians in practices within the 14 DFCM academic sites throughout the Greater Toronto Area and beyond. The network brings together DFCM researchers, primary care clinicians and practices from all its academic sites to answer important health care questions and translate findings into practice. On a national level, Dr. Greiver leads a team of more than 50 investigators in a research project to support primary care practices in optimizing care for older patients with polypharmacy. The SPIDER (Structured Process Informed by Data, Evidence and Research) study will be conducted in seven Practice-Based Research Networks (PBRNs) across five provinces in one of the largest PBRN-Quality Improvement (QI) collaborations in Canada.

Papers: In the March 2018 issue of npj Primary Care Respiratory Medicine, Dr. Michelle Greiver leading and corresponding author to the publication of “Agreement between hospital and primary care on diagnostic labeling for chronic obstructive pulmonary disease (COPD) and heart failure (HF) in Toronto, Canada: a cross-sectional observational study”, identified low rates of labeling agreement for COPD and HF between a hospital and its primary care community in addition to missing labels in both settings. This publication further discusses the importance of improving the documentation of these COPD and HF high-cost conditions in order to be able to develop robust data bases that will ultimately be used to promote patient care as well as collaborative research initiatives.

In the March 2018 issue of the Journal of Evaluation in Clinical Practice, Dr. Michelle Griever leading author of the publication “Would you like to add a weight after this blood pressure, doctor? Discovery of potentially actionable associations between the provision of multiple screens in primary care”, evidenced that current guidelines recommend screening for risk factors associated with chronic


Michelle Greiver: Gordon F. Cheesbrough Research Chair in Family and Community Medicine


team studied associations among the recording of chronic disease prevention, screening, and management (CDPSM) elements in EMRs and ranked important relationships between these elements. The study performed association rule mining methods that are currently used to explore relationships between numerous combinations of item sets, as may be encountered in medical transactional databases such as those found in primary care. The study suggests that this could contribute to planning new approaches for improving the recording of key chronic disease risk factors in primary care through prompts based on associations. Significantly, these associations could be used to implement data driven alerts leading to the improvement of primary care. Presentations: Dr. Michelle Greiver attended the North American Primary Care Research Group (NAPCRG) annual meeting in Chicago where on November 12th she delivered a talk entitled “Trends in Systemic Recording Errors of Blood Pressure and Association with Outcomes in Canada and UK Primary Care: a Retrospective Observational Study.” The presentation explains that in the recording of blood pressure (BP) end digit preference (EDP) and systematic bias is common, this can lead to errors in management

Appointments & Awards: In January 2018, Dr. Michelle Greiver received the news that NYGH has been approved to be the hub for the Diabetes Action Canada (DAC) data repository. DAC is a Strategic Patient Oriented Research (SPOR) Network in Diabetes and its Related Complications, part of the CIHR-SPOR Program in Chronic Disease. Its mission is to transform the health outcomes of people living with diabetes and its related complications. It will facilitate important and meaningful connections between patients, their primary healthcare providers, and specialists to improve health care with significant cost savings for the health system. The National Diabetes Data Repository was launched in June which is managed at NYGH. October of this year saw Dr. Michelle Greiver become a member of the DAC Steering Council and attend the national face to face meeting in Halifax on October 12th during the 21st Professional Conference and Annual Meeting. As a member of the Steering Council, Dr. Greiver will oversee all aspects of the workings of the DAC Strategy for the Patient-Oriented Research (SPOR) Network.

and unfavourable health outcomes. A possible solution would be the use of Automatic Office BP (AOBP). The aim was to assess the correlation between trends in systematic BP recording errors and adverse cardiovascular outcomes. The use of AOBP was associated with a decrease in EDP levels. Adverse cardiovascular outcomes were of a higher frequency at sites with higher rates of EDP. The conclusion of this presentation was that routine use of automated office-based BP measurement should be standard for all relevant consultations.

diseases but existing electronic prompts have limited effects. To address this important issue Dr. Greiver’s



Clinical trials feature prominently in our strategy to build research capacity. Two years ago, we created the new position of Clinical Trials Manager and hired Munaza Jamil. She built a team and connected successfully with various clinical trials sponsors to increase the scope of treatment options available to patients. Munaza moved on in January, 2018 and we are thrilled that Maria Schlag has taken the lead. Maria brings extensive experience with clinical trials at the Princess Margaret Cancer Centre. As shown below, 16 clinical trials have started since November 2013 and many more are under consideration.

Every clinical trial must be approved by a Research Ethics Board (REB), which safeguards the rights of participants. The NYGH REB belongs to the Clinical Trials Ontario’s elite group of qualified REB’s in Ontario. The journey to become qualified was anything but trivial and this is a significant achievement by the members of the REB and the supporting staff.

Area Start Date

Study Principal Investigator

Sponsor Note (Appendix I)

Colorectal Cancer

Nov-13 Periop Dr. Stotland OHRI 1

Pediatric Nov-16 Pediatric Bronchiolitis

Dr. Kanani CIHR 2

Breast Cancer Mar-17 Treat ER+ight

Dr. Glenns Novartis 3

Nerve Injury Mar-17 RANGER Dr. El Sheikh AxoGen 4

Intensive Care Unit

Apr-18 PROMIZING Dr. Shin OHRI 5

Surgery Mar-17 Ileostomy Dr. Feinberg McGill University 6

Liver Disease May-17 Gilead 1944 Dr. Elkhashab Gilead Sciences 7

Liver Disease May-17 Gilead 1943 Dr. Elkhashab Gilead Sciences 8

Breast Cancer May-17 ALLIANCE Dr. Osman Canadian Cancer Trials Group 9

Antibiotics Jul-17 Balance RCT Dr. Shin Sunnybrook 10

Liver Disease Aug-17 STELLARIS Dr. Elkhashab Allergan Pharmaceuticals 11

Kidney Cancer Jun-18 ImMotion Dr. Robson Roche Alzheimer’s disease

Jun-18 Alzheimer’s Study

Dr. Tseng Boehringer Ingelheim 12

Surgical Oncology

Jul-18 NOM Study Dr. Stotland Sunnybrook 13

Breast Cancer Sep-18 MONARCHe Dr. Yu Eli Lilly 14

Colon Cancer Sep-18 CO27 Dr. Roitman CCTG 15

Antibiotic Sep-18 Balance on the Ward

Dr. Shin Sunnybrook 16


II. Transforming the Delivery of Care through Clinical Trials


“The thing about ideas is that they naturally inspire new ones. This is why places that facilitate idea sharing tend to become more productive and innovative than those that don’t. Because

when ideas are shared, the possibilities do not add up. They multiply.” Paul Romer, Economist.

NYGH is extremely well positioned to improve and transform patient care through endless development. This transformation is assured by the key role R&I plays contributing to quality, efficiency and excellence in patient-centred care. A necessary precursor for innovation to occur is to have a well-established academic foundation for the dissemination and development of new ideas. This academic foundation emerged four years ago and continues to grow by improving key health care aspects of this leading community hospital. Since then, R&I has been working in a collaborative open space encouraging communications and ideas exchange at internal and external levels.

R&I Communications Strategy

Certainly, the more the knowledge is used and shared the more it enriches the research leading to innovations for better patient care. The R&I communication strategy has been established along these lines where research achievements are communicated through the NYGH R&I external website, peer-reviewed publications involving NYGH staff and physicians, oral and poster conference presentations as well as mass media (see Appendix II), media showcases, NYGH Research Spotlight and the North York General Foundation promotion. We are currently assisting a flourishing time where our research has been part of different mass media systems promoting our communication strategy. An important aspect of our communication strategy is to not use paid advertising as well as to not produce a printed annual R&I report which is customarily done by many research institutions. Instead, our accomplishments are promoted by free mass media that is known to play a critical role in the connection between science and society, as well as this Annual Report in PDF format. We believe that money should be used to generate more research and innovation achieving the ultimate goal of contributing to the improvement of healthcare. On this line, we have periodical meetings with NYGH communications experts to better thrust our communication strategy as is shown in the NYGH news below.


III. Communications


Our progress at this early stage is reflected in various indicators of research productivity. As shown earlier, external funding for research has grown from essentially zero in 2014 to $1.5 million in 2018. Appendix II shows that NYGH is gaining recognition for research and innovation. Our researchers are invited more and more to national and international conferences. And they are publishing more. The chart on the right shows the number of peer-reviewed publications in each calendar year climbing steadily. The actual list tracked by PubMed is maintained on our website and a list of the publications is captured in Appendix III.

In December 2012, NYGH launched the Exploration Fund, a competitive granting competition designed to provide initial funding for staff and physicians to develop new ideas for the delivery of care. Among the first of its kind in Canada, the Exploration Fund was seeded with a donation by Brad and Kathy Badeau, and their contribution has been augmented by the hospital, the North York General Foundation, the Sellors Family, and the Savlov Family.

The Sellors Family Research Grant is a designated time-limited fund within the Exploration Fund, to support research in the areas of autoimmune disease, neurology, and quality of life. The Savlov Family Paediatric Endowment Fund is a fund that supports clinical research and/or education — all pursuits to benefit paediatric care across all disciplines and departments at NYGH.

The Exploration Fund has funded 39 projects, listed below, to a wide range of promising investigators, from a surgeon studying the effects of music on children undergoing elective surgery, to a geriatric emergency nurse trying multisensory interventions to help calm patients with dementia.

Dr. Phillip Shin Diana Adams Dr. Lea Velsher Monakshi Sawhney Sumit Raybardhan Dr. Michelle Greiver Dr. Joyce Lee Dr. Wendy Meschino Dr. Sharifa Himidan

Mark Fam Prof. Hannah Wong Dr. Alan Fung Dr. Warren Lewin Prof. Farah Ahmad Dr. Frank Sullivan Prof. Christo El Morr Prof. Christine Till

Dr. Fahima Osman

Dr. Kevin Katz Dr. Pavani Das Sumon Acharjee Samantha Moe Sonja Rebryna Dr. Risa Bordman Dr. Nicole Golda Dr. Lloyd Smith Susan Woollard

Dr. Nicole Golda Dr. Valerie Caraiscos Dr. Sanjho Srikandarajah Dr. Jennifer Mills Dr. Nina Horvath Katelyn Chown Dr. David Rosenthal Dr. Modupe Tunde-Byass Julie Makarski

0

20

40

60

80

2014 2015 2016 2017 2018

Peer-Reviewed Publications

Research Indicators

Exploration Fund



Already, Exploration Fund recipients have leveraged the support to submit proposals for external funding and make presentations at conferences. It has also helped investigators to publish findings in peer-reviewed journals, such as:

• Allowed Drs. Frank Sullivan and Braden O’Neill to identify top 10 international primary care research priorities having the potential to guide research allocation, supporting funding agencies and initiatives to promote global care research practice

• Allowed Dr. Farah Ahmad to conduct research and publish a scoping review on symptoms and experience of depression among Chinese communities in the West

In 2018, the Exploration Fund funded 4 projects – allowing the people listed below to embark upon pilot studies to test preliminary ideas.

• “Improved pregnancy outcomes with Shirodkar cervical cerclage compared with McDonald cerclage” Dr. David Rosenthal Award: $7,500

• “Young women with breast cancer – meeting unmet needs through the nurse navigator model care” Ms. Katelyn Chown Award: $6,338

• “Decreasing caesarean sections by supporting Trial of Labour After Caesarean section (TOLAC). A QI project at Mount Sinai, St. Michael’s and North York General Hospital” Dr. Modupe Tunde-Byass Award: $7,500

• “Enhancing Patient Care and Delivery through Research on the “Front-lines”: Assessing needs to build research capacity among healthcare professionals at North York General Hospital” Ms. Julie Makarski Award: $3,786.35



Appendix I: Full Title of Clinical Trials at NYGH



1. A Multicentre Randomized Controlled Trial of the Use of Extended Peri-Operative Low Molecular Weight Heparin to Improve Cancer Specific Survival Following Surgical Resection of Colorectal Cancer

2. Intermittent vs. Continuous Oxygen Saturation Monitoring in Infants Hospitalized for Bronchiolitis: A Randomized Controlled Trial

3. Treat ER+ight: Treatment of Canadian Postmenopausal Women with ER+ Advanced Breast Cancer in the Real-World Setting with Hormone Therapy ± Targeted Therapy

4. A Multicenter Registry Study of Avance® Nerve Graft Utilization, Evaluations and Outcomes in Peripheral Nerve Injury Repair. (RANGER®)

5. Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study

6. Does Bowel Stimulation Before Loop Ileostomy Closure Reduce Postoperative Ileus? A Multicenter Randomized Controlled Trial

7. Safety and Efficacy of Selonsertib in Adults With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) (STELLAR 4)

8. Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis (STELLAR 3)

9. A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) who have Positive Sentinel Lymph Node Diseaae after Neoadjuvant Chemotherapy

10. Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Control Trial

11. A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Cenicriviroc for the Treatment of Liver Fibrosis in Adult Subjects with Nonalcoholic Steatohepatitis

12. A Multi-centre, Double-blind, Parallel-group, Randomised Controlled Study to Investigate Efficacy and Safety of Orally Administered BI 425809 During a 12-week Treatment Period Compared to Placebo in Patients With Cognitive Impairment Due to Alzheimer’s Disease.

13. Does Bowel Stimulation Before Loop Ileostomy Closure Reduce Postoperative Ileus? A Multicenter Randomized Controlled Trial

14. A Randomized, Open-Label, Phase 3 Study of Abemaciclib Combined With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone in Patients With High Risk, Node Positive, Early Stage, Hormone Receptor Positive, Human Epidermal Receptor 2 Negative, Breast Cancer

15. A Phase III, Randomised, International Trial Comparing mFOLFIRINOX Triplet Chemotherapy to mFOLFOX for High-risk Stage III Colon Cancer in Adjuvant Setting

16. Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness- BALANCE on the Wards: A Pilot Randomized Controlled Trial

through Research on the “Front-lines”: Assessing needs to build research capacity among healthcare professionals at North York General Hospital”

Appendix II: Media Coverage

R&I Researcher Date Media event Title

Michelle Greiver February 13, 2018

University of TorontoFaculty of MedicineDepartment of Family and Community Medicine (Link)

Marketing Techniques Could be Used in Health Screening, Researchers Claim

Patricia Trbovich February 22, 2018

Tweets.@_ NYGH_News (Link) NYGH Steinberg Family Surgical Safety Program

Monika KastnerPatricia TrbovichKatie Dainty

March 8, 2018 NYGH News & Community, 2018 (Link)

International Women's Day 2018

Katie Dainty March, 2018 IHPME. Connect (Link) NEW RESEARCH: Community Paramedics Offer an Alternate Resource for Chronically Ill Patients

Michelle Greiver March 16, 2018

NYGH News & Community, 2018 (Link)

Merging hospital and community data to advance research

Katie Dainty March 22, 2018

U of T news (Link)NYGH in the News (Link)Tweets. @_NYGH_News (Link)

U of T study looks at benefits of having community paramedics do home visits for chronically ill patients

Katie Dainty March 27, 2018

Radio interview with SiriusXM Radio

Research on Community Paramedics

Patricia Trbovich April 5, 2018 NYGH News & Community, 2018 (Link)The Pulse (Link)

Patient safety research ready for take off

Michelle GreiverMonika Kastner

April 12, 2018 NYGH in the News, Research Spotlight (Link)

SPIDER funded $2.6Million to improve care for elderly patients living with polypharmacy

Patricia TrbovichMichelle GreiverKatie DaintyMonika Kastner

April 18, 2018 NYGH News & Community, 2018 (Link)

Research ever-expanding at NYGH

Michelle Greiver May 1, 2018 St. Michael’s Hospital. Newsroom (Link)

CIHR funds two DFCM projects to support Canadian primary care

Patricia Trbovich May 4, 2018 Tweets, @_NYGH_News (Link) Innovative ways to reduce harmful events in health care. 5th annual InnovationEx

Patricia Trbovich May 8, 2018 HealthPro News (Link) What we learned from InnovationEX 2018

Patricia Trbovich May 8, 2018 Carleton Newsroom (Link) Carleton Conference Examines How to Reduce Medical Errors

Michelle Greiver May 9, 2018 Canadian Healthcare Technology (Link)

Team gains $2.6 million to battle ‘polypharmacy’

Michelle Greiver May 15, 2018 Diabetes Action Canada (Link) Congratulations Michelle Greiver On Being Awarded a $2.6 Million Competitive Operating Grant

Michelle Greiver May 31, 2018 Tweets. @_DiabetesAction (Link)

News release: Launch of the Diabetes Action Canada National Diabetes Repository

Patricia Trbovich June 4, 2018 Healthcare Insurance Reciprocal of Canada News (Link)

How InnovationEX is not only leading the conversation, but also the rapid execution of new ideas



Michelle Greiver June 25, 2018 York University. News (Link) York-led Health Ecosphere project celebrates resulting healthcare innovation

Maria Schlag July 5, 2018 NYGH in the News, Research Spotlight (Link)

Clinical trials at North York General Hospital

Maria Schlag July 5, 2018 Tweets. @_NYGH_News (Link) Clinical trials at North York General Hospital

Katie Dainty August 22, 2018

U of T News (Link) She helped victims of the Toronto van attack. Now this CPR trainer is coming to U of T for resuscitation research

Monika Kastner August 27, 2018

CMAJ Podcasts (Link) Treating seniors who have multiple high-burden chronic diseases


Reuters, Health News (Link) Seniors healthier when medical care is coordinated


St.Michael’s Hospital, Newsroom (Link)

Care co-ordination improves health of older patients with multiple chronic diseases


MedicalXpress, Canadian Medical Association Journal (Link)

Care coordination improves health of older patients with multiple chronic diseases


Physician’s Weekly. Healthday (Link)

Care Coordination Strategies Aid in Multiple Chronic Diseases


McKnight’s. Long-Term care news (Link)

Coordinated care more effective for residents with multiple chronic conditions, study finds


PriMed. Clinical Resources. Medical News (Link)

Care Coordination Strategies Aid in Multiple Chronic Diseases


BioIQ. The Friday Five (Link) Population Health News, August 27 – 31

Katie Dainty September 10, 2018

Institute of Health Policy, Management and Evaluation, University of Toronto News (Link)

Co-designing Health Care Solutions for Cardiac Arrest Survivors and Bystanders, U of T joint study

Patricia Trbovich September 14, 2018

North York General @NYGH_News (Link)

NYGH Research Chair Patricia Trbovich focuses on reducing preventable medical errors

Patricia Trbovich September 17, 2018

Council of Academic Hospitals of Ontario (CAHO). Healthier, Wealthier, Smarter. Tweets (Link)

Research Chair @NYGH_News, Patricia Trbovich

Michelle Greiver September 17, 2018

Council of Academic Hospitals of Ontario (CAHO). Healthier, Wealthier, Smarter (Link)

CAHO hospitals are driving safer prescribing practices for Ontarians


Tweets. @_NYGH_News (Link) Older Canadians are taking up to ten or more prescription medications.


Tweets #onWHS (Link) Older Canadians are taking up to ten or more prescription medications.


DFCM Utoronto_News (Link) Dr. Michelle Greiver to lead the University of Toronto Practice-Based Research Network (UTOPIAN)





Diabetes Action Canada. News (Link)

Congratulations Dr. Michelle Griever, the new Gordon F. Cheesbrough Research Chair


ICES On Tap (Link)

Michelle Greiver to lead the University of Toronto Practice-Based Research Network

Michelle Greiver October 10, 2018

NYGH News & Community, 2018 The Pulse Link

Dr. Michelle Greiver: Leader in primary care research New Gordon F. Cheesbrough Research Chair in Family and Community Medicine

Patricia Trbovich November 12, 2018

U of T News Link U of T researcher on why a black box in the OR is good for health care

Michelle Greiver November 13, 2018

Compute Ontario. News/Blog Link

Diabetes research gets a security upgrade

Patricia Trbovich November 25, 2018

The Varsity Link

‘Black box’ collects data from the operating room U of T professor Teodor Grantcharov’s invention could improve medical outcomes




Appendix III: Peer-Reviewed Publications in Calendar 2018



1. Dr. Valerie Caraiscos… Contributing author of Shaulov A. et al.: Pain in patients with newly diagnosed or relapsed acute leukemia. Support Care Cancer. PubMed

2. Tianhua Huang and Dr. Wendu Meschino… Contributing authors of Igbal J. et al.: Hormone Levels in Pregnancy and Subsequent Risk of Maternal Breast and Ovarian Cancer: Systematic Review. J Obstet Gynaecol Can. PubMed

3. Dr. Kevin Katz… Contributing author of Nichols M.K. et al.: The Impact of Prior Season Vaccination on Subsequent Influenza Vaccine Effectiveness (VE) to Prevent Influenza-Related Hospitalizations over Four Influenza Seasons in Canada. Clin Infect Dis. PubMed

4. Jennifer Holmes-Haronitis… Contributing author of Cleverley K. et al.: Facilitating Effective Transitions from Hospital to Community for Children and Adolescent Mental Health Services: Overview of the Transition Support Worker Role and Function. J Can Acad Child Adolesc Psychiatry. PubMed

5. Dr. Sanjho Srikandarajah… Contributing author of Goel A. et al.: The perioperative patient on buprenorphine: a systematic review of perioperative management strategies and patient outcomes. Can J Anaesth. PubMed

6. Dr. Ronik Kanani… Contributing author of Adams S. et al.: Care Maps and Care plans for Children with Medical Complexity. Child Care Health Dev. PubMed

7. Dr. Wendy Meschino… Contributing author of Aref-Eshghi E. et al.: BAFopathies’ DNA methylation epi-signatures demonstrate diagnostic utility and functional continuum of Coffin-Siris and Nicolaides-Baraitser syndromes. Nat Commun. PubMed

8. Dr. Victor Feder and Katherine Fibiger… Leading and contributor authors, respectively, of Feder V. et al.: On the Very, Very Frontlines of Mental Health Care. Psychiatr Serv. PubMed

9. Brian Minnema… Contributor of Morris et al.: Long-Term Effects of Phased Implementation of Antimicrobial Stewardship in Academic ICUs: 2007-2015. Crit Care Med. PubMed

10. Dr. F. Ahmad, Dr. W.L.A. Fung, C. Maule an J. Wang… Dr. Ahmad F. Leading author, Maule C. and Wang J. contributing authors and Fung W.L.A. corresponding author of Ahmad F. et al.: Symptoms and Experience of Depression Among Chinese Communities in the West: A Scoping Review. Harv Rev Psychiatry. PubMed

11. Dr. Michelle Greiver and Dr. Franks Sullivan… Corresponding authors of Rigobon A.V. et al.: Impact of the Diabetes Canada Guideline Dissemination Strategy on the Prescription of Vascular Protective Medications: A Retrospective Cohort Study, 2010-2015. Diabetes Care. PubMed

12. Dr. Braden O’Neill and Dr. Frank Sullivan… Corresponding and contributing authors, respectively of O’Neill et al.: Identifying top 10 primary care research priorities from international stakeholders using a modified Delphi method. PubMed

13. Katie Dainty… Contributing author of Snobelen P.J. et al.: Helping Those Who Help. Circ Cardiovasc Qual Outcomes. PubMed

14. Patricia Trbovich… Corresponding author of Trbovich P. and Vincent C.: From incident reporting to the analysis of the patient journey. BMJ Qual Saf. PubMed

15. Dr. Usmaan Hameed… Contributing author of Feinberg A.E. et al.: Survival and peri-operative outcomes among patients with rectal cancer: the role of prior radiotherapy due to prostate cancer. Int J Colorectal Dis. PubMed



16. Dr. Kevin Katz…Contributing author of Boyd D.A. et al.: Results from the Canadian Nosocomial Infection Surveillance Program for detection of carbapenemase-producing Acinetobacter spp. in Canadian hospitals, 2010-16. J Antimicrob Chemother. PubMed

17. Tianhua Huang, Shelley Dougan, Dr. Mark Walker, Dr. Christine Armour and Dr. Nan Okun… Tianhua Huang leading and corresponding author, Shelley Dougan, Dr. Mark Walker, Dr. Christine Armour and Dr. Nan Okun contributing authors of Huang T. et al.: Trends in the use of prenatal testing services for fetal aneuploidy in Ontario: a descriptive study. CMAJ Open. PubMed

18. Dr. Ronald Goldenberg… Contributing author of Mancini G.B.J. et al.: CardioDiabetes: Core Competencies for Cardiovascular Clinicians in a Rapidly Evolving Era of Type 2 Diabetes Management. Can J Cardiol. PubMed

19. Katie Dainty… Contributing author of Korenvain C. et al.: Exploring deprescribing opportunities for community pharmacists: Protocol for a qualitative study. Can Pharm J (Ott). PubMed

20. Jessica Auyeung and Monica Lee… Corresponding and contributing authors of Auyeung et al.: Successful Treatment of Stevens-Johnson Syndrome with Cyclosporine and Corticosteroid. Can J Hosp Pharm. PubMed

21. Dr. Wendy Meschino… Contributing author of Dossa F. et al.: Real-world health services utilisation and outcomes after BRCA1 and BRCA2 testing in Ontario, Canada: the What Comes Next Cohort Study protocol. BMJ Open. PubMed

22. Jessica Tomasi, Carly Warren, Lauren Kolodzey and Patricia Trbovich… Jessica Tomasi, Leading author, Carly Warren and Lauren Kolodzey, contributing authors and Patricia Trbovich, Corresponding author of Tomasi J. et al.: Convergent parallel mixed-methods study to understand information exchange in paediatric critical care and inform the development of safety-enhancing interventions: a protocol study. BMJ Open. PubMed

23. Dr. Kevin Katz… Contributing author of Buchan S.A. et al.: Characteristics and Outcomes of Young Children Hospitalized with Laboratory-Confirmed Influenza or Respiratory Syncytial Virus in Ontario, Canada, 2009-2014. Pediatr Infect Dis J. PubMed

24. Monika Kastner and Leigh Hayden… Corresponding and contributing authors of Kastner M. et al.: Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis. CMAJ. PubMed

25. Joanne Honeyford, Dr. Elyse Lackie and Dr, Modupe Tunde-Byass… Leading, contributing and corresponding authors of Pinnaduwage L. et al.: A Comparison of the Number of Patient Visits Required for Different Management Options for Early Pregnancy Loss at an Early Pregnancy Assessment Clinic. J Obstet Gynaecol Can. PubMed

26. Joanne Honeyford, Dr. Elyse Lackie and Dr, Modupe Tunde-Byass… Leading, contributing and corresponding authors of Pinnaduwage L. et al.: The Sustained Value of an Early Pregnancy Assessment Clinic in the Management of Early Pregnancy Complications: A 10-Year Retrospective Study. J Obstet Gynaecol Can. PubMed

27. Dr. Elad Mei-Dan and Dr. Claire Dougan… Corresponding and contributing authors of Mei-Dan E. et al.: Planned cesarean or vaginal delivery for women in spontaneous labor with a twin pregnancy: A secondary analysis of the Twin Birth Study. Birth. PubMed



28. Dr. Marjan Nezarati… Contributing author of Chitayat D. et al.: An Additional Individual with a De Novo Variant in Myelin Regulatory Factor (MYRF) with Cardiac and Urogenital Anomalies: Further Proof of Causality: Comments on the article by Pinz et al. Am J Med Genet A. PubMed

29. Dr. Jacqueline Wong… Contributing author of Mehta K. et al.: Zoonotic Influenza and Human Health-Part 2: Clinical Features, Diagnosis, Treatment, and Prevention Strategies. Curr Infect Dis Rep. PubMed

30. Dr. Jacqueline Wong… Contributing author of Goneau L.W. et al.: Zoonotic Influenza and Human Health-Part 1: Virology and Epidemiology of Zoonotic Influenzas. Curr Infect Dis Rep. PubMed

31. Dr. Wendy Meschino… Contributing author of McCuaig J.M. et al.: Evolution of genetic assessment for BRCA-associated gynaecologic malignancies: a Canadian multisociety roadmap. J Med Genet. PubMed

32. Dr. Ravi Bajaj… Contributing author of Tan N.S. et al.: Metabolic cardiomyopathy from propionic acidemia precipitating cardiac arrest in a 25-year-old man. CMAJ. PubMed

33. Tianhua Huang and Dr. Wendy Meschino… Corresponding and contributing authors of Huang T. et al.: Enhanced First Trimester Aneuploidy Screening with Placental Growth Factor and Alpha Feto-Protein: Detection of Trisomies 18 and 13. J Obstet Gynaecol Can. PubMed

34. Dr. Lea Velsher… Contributing author of McMillan H.J. et al.: Recessive mutations in ATP8A2 cause severe hypotonia, cognitive impairment, hyperkinetic movement disorders and progressive optic atrophy. Orphanet J Rare Dis. PubMed

35. Dr. Wendy Meschino and Tianhua Huang… Contributing authors of Ray J.G. et al.: Prenatal biochemical screening and long term risk of maternal cardiovascular disease: population based cohort study. BMJ. PubMed

36. Monika Kastner… Contributing author of Gupta S. et al.: Patient Preferences for a Touch Screen Tablet-Based Asthma Questionnaire. J Asthma. PubMed

37. Dr. Simon Raphael… Contributing author of Smith C.R. et al.: The impact of organized breast assessment on survival by stage for screened women diagnosed with invasive breast cancer. Breast. PubMed

38. Dr. Kevin Katz… Corresponding author of Katz K.C. et al.: The evolving epidemiology of Clostridium difficile infection in Canadian hospitals during a postepidemic period (2009-2015). CMAJ.PubMed

39. Marla Engelberg… Contributing author of Dimitropoulos G. et al.: Family-based treatment for transition age youth: parental self-efficacy and caregiver accommodation. J Eat Disord. PubMed

40. Dr. Kevin Katz… Contributing author of Tai X. et al.: Comparison of response rates on invitation mode of a web-based survey on influenza vaccine adverse events among healthcare workers: a pilot study. BMC Med Res Methodol. PubMed

41. Monika Kastner… Contributing author of Moore J.E. et al.: Supporting the implementation of stroke quality-based procedures (QBPs): A mixed methods evaluation to identify KT activities, KT interventions, and determinants of implementation across Ontario. Health Services Research. PubMed

42. Dr. Fahima Osman… Contributing author of Somogyi R.B. et al.: Breast reconstruction: Updated overview for primary care physicians. Can Fam Physician. PubMed

43. Dr. Adrian Brown… Contributing author of Green C.R. et al.: Choisir avec soin : les 10 principales recommandations de la SOGC. J Obstet Gynaecol Can. PubMed

44. Dr. Kevin Katz… Contributing author of Volling C. et al.: Immunogenicity and reactogenicity of high- vs. standard-dose trivalent inactivated influenza vaccine in healthcare workers: a pilot randomized controlled trial. Clin Microbiol Infect. PubMed



45. Dr. Daphna Grossman… Contributing author of Iaboni A. et al.: The Value of a Palliative Frame in Advanced Dementia. Am J Geriatr Psychiatry. PubMed

46. Brenda Bailey… Contributing author of Stiell I.G. et al.: A Multicenter Program to Implement the Canadian C-Spine Rule by Emergency Department Triage Nurses. Ann Emerg Med. PubMed

47. Katie Dainty… Corresponding author of Haywood K. and Dainty K.N.: Life after cardiac arrest: The importance of engaging with the ‘forgotten patient’. Resuscitation. PubMed

48. Dr. Frank Sullivan… Contributing author of Lamber M.A. et al.: Prevalence and Distribution of Atherosclerosis in a Low- to Intermediate-Risk Population: Assessment with Whole-Body MR Angiography. Radiology. PubMed

49. Katie Dainty… Contributing author of Archambault P.M. et al.: Recommendations for patient engagement in patient-oriented emergency medicine research. CJEM. PubMed

50. Dr. Ronik Kanani… Contributing author of Mahant S. et al.: Intermittent versus continuous oxygen saturation monitoring for infants hospitalised with bronchiolitis: study protocol for a pragmatic randomised controlled trial. BMJ Open. PubMed

51. Patricia Trbovich… Contributing author of Gilbert R.E. et al.: Intravenous Chemotherapy Compounding Errors in a Follow-Up Pan-Canadian Observational Study. J Oncol Pract. PubMed

52. Dr. Frank Sullivan Corresponding author, Michelle Greiver and Braden O’Neil… contributing authors of Willison D..J. et al.: Canada’s future health care system. CMAJ. PubMed

53. Katie Dainty… Contributing author of Leary M. et al.: Examining the Use of a Social Media Campaign to Increase Engagement for the American Heart Association 2017 Resuscitation Science Symposium. J Am Heart Assoc. PubMed

54. Patricia Trbovich… Senior author of Petrosoniak A. et al.: Tracking workflow during high-stakes resuscitation: the application of a novel clinician movement tracing tool during in situ trauma simulation. BMJ Simulation & Technology Enhanced Learning. PubMed

55. Jennifer Quaglietta and Karyn Popovich… Authors of Quaglietta J. et al.: Experience of Care - Furthering the Patient Experience Agenda. Healthc Pap. PubMed

56. Dr. Roger Buckley… Contributing author of Wallis C.J.D. et al.: The effect of selection and referral biases for the treatment of localised prostate cancer with surgery or radiation. Br J Cancer. PubMed

57. Dr. Richard Bowry… Contributing author of Vorobeichik L. et al.: Should continuous rather than single-injection interscalene block be routinely offered for major shoulder surgery? A meta-analysis of the analgesic and side-effects profiles. Br J Anaesth. PubMed

58. Dr. Frank Sullivan… Contributing author of Weir-McCall J.R. et al.: Development and Validation of a Path Length Calculation for Carotid-Femoral Pulse Wave Velocity Measurement: A TASCFORCE, SUMMIT, and Caerphilly Collaborative Venture. Hypertension. PubMed

59. Dr. Kevin Katz… Contributing author of Nichols M.K. et al.: Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network). Vaccine. PubMed

60. Dr. LorneTugg… Contributing author of Francombe Pridham K. et al.: Exploring experiences with compulsory psychiatric community treatment: A qualitative multi-perspective pilot study in an urban Canadian context. Int J Law Psychiatry. PubMed



61. Katie Dainty and Bianca Seaton… Corresponding and contributing authors of Dainty K.N. et al.: Home Visit-Based Community Paramedicine and Its Potential Role in Improving Patient-Centered Primary Care: A Grounded Theory Study and Framework. Health Serv Res. PubMed

62. Sumit Raybardhan… Contributing author of Wu J.H. et al.: Potential Negative Effects of Antimicrobial Allergy Labelling on Patient Care: A Systematic Review. Can J Hosp Pharm. PubMed

63. Cynthia Cheng… Leading and corresponding author and Fatima Mithoowani and Monica Lee… contributing authors of Cheng C. et al.: Interaction between Psychotropic Medications and Alcohol: Perceptions among Patients Attending an Adult Mental Health Day Hospital Program. Can J Hosp Pharm. PubMed

64. Dr. Michelle Greiver… Leading and corresponding author, Dr. Frank Sullivan, Deepak Sharma, Steven Bernard, Dr. David Eisen and Navid Rahman… contributing authors of Greiver M. et al.: Agreement between hospital and primary care on diagnostic labeling for COPD and heart failure in Toronto, Canada: a cross-sectional observational study. NPJ Prim Care Respir Med. PubMed

65. Dr. Frank Sullivan… Corresponding author of McDonnell L. et al.: Finding and using routine clinical datasets for observational research and quality improvement. Br J Gen Pract. PubMed

66. Dr. Simon Raphael… Contributing author of Slodkowska E. et al.: Fibroepithelial lesions of the breast: a comprehensive morphological and outcome analysis of a large series. Mod Pathol. PubMed

67. Dr. Kimberly Lazare … Contributing author of Chu GCW. Et al.: Serum and blood based biomarkers for lung cancer screening: a systematic review. BMC Cancer. PubMed

68. Dr. Kevin Katz… Contributing author of Hussain H. et al.: Factors associated with influenza vaccination among health care workers in acute care hospitals in Canada. Influenza Other Respir Viruses. PubMed

69. Dr. Wendy Meschino… Contributing author of Lammert J. et al. : Physical activity during adolescence and young adulthood and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat. PubMed

70. Dr. Frank Sullivan… Contributing author of Weir-McCall JR. et al.: Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study. J Cardiovasc Magn Reson. PubMed

71. Dr. Wendy Meschino… Contributing author of Eisen A. et al.: Genetic assessment wait time indicators in the High Risk Ontario Breast Screening Program. Mol Genet Genomic Med. PubMed

72. Dr. Kevin Katz… Contributing author of Kwong JC. et al.: Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection. N Engl J Med. PubMed

73. Katie N. Dainty… Contributing author of Leary et al.: The Latest in Resuscitation Science Research: Highlights from the American Heart Association’s 2017 Resuscitation Science Symposium. J Am Heart Assoc. PubMed

74. Dr. Frank Sullivan and Dr. Michelle Greiver… corresponding and contributing authors, respectively, of Kalia S. et al.: Would you like to add a weight after this blood pressure, doctor? Discovery of potentially actionable associations between the provision of multiple screens in primary care. J Eval Clin Pract. PubMed

75. Dr. Daphna Grossman… Contributing author of Iaboni A. et al.: A Palliative Approach to Falls in Advanced Dementia. Am J Geriatr Psychiatry. PubMed

Katie Dainty: Research Chair in Patient-Centred Outcomes · science, patient-centred outcome...

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