DR. Dr. Nurmiati Amir, SpKJ(K)Department of Psychiatry University of Indonesia

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Biopsychosocial model: George Engel (1997)BIOLOGYPSYCHOLOGY

SOCIAL

*Factors influencing the degree or severity of illness / mental disorder of a personSeverity of stressorSevereMildResilience / perceptionPersonalitystrongweakHealthyUnhealthy / sick

*Environmental riskGenetic predispositionB

*PSYCHOSOCIAL STRESSORPSYCHOENDOCRINE SYSTEMCHPA-AXISC-SMA AXISFEAR / ANXIETY

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*Disturbance in temporal lobe is related to:HalusinationDelutionNot recognize an object or face

*Frontal lobe hypoactivity:decreased cognitive functionDisturbance in behavioral planningBlunted affectSocial isolationApathyect

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*ACETYLCHOLINAGONISANTAGONISDEPRESSIONMANIAPsychmotor retardationLethargySleep disturbanceLearned helplessnessMotor hyperactivityEnergeticNo need to sleepSelf esteem

*DOPAMINE SYSTEMTUBERO INFUNDIBULARSUBSTANSIA NIGRAMESOLIMBICMESOCORTEXCONTROLLED PROLACTINEMOTOR ACTIVITYEMOTION EXPRLEARNINGREINFORCEMENTHEDONIAMOTIVATIONCONCENTRATIONEXCECUTIVE FCPROLACTINE SUBSTANSIA NIGRA MESOLIMBIC MESOCORTEX MANIA/DEPRESSION

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*The same symptom might be shown in schizophrenia and bipolar, because the limbic system involves in both disorder

*CONCLUSIONS

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*******SISTEM LIMBIK 1DISFUNGSI SISTEM LIMBIKPADA SKIZOFRENIAPADA GANGGUAN BIPOLARSIMPTOM POSITIFGANGGUAN EMOSI DAN PERILAKUWAHAMHALUSINASI GEJALA YANG SAMA DAPAT DITEMUKAN PADA SKIZOFRENIA DAN BIPOLARSIMTEM LIMBIK TERLIBAT PADA KEDUANYA*