14th Interdisciplinary Cerebrovascular Symposium

June 28-30, 2017FINAL PROGRAM

CorumMontpellier

FRANCEwww.ics2017.fr

ICS 2017

chairman Alain Bonafé, Montpellier

co-chairman Franck Nicoud, Montpellier

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Edito

It is a great pleasure to welcome you for the four-teenth Interdisciplinary Cerebrovascular Sympo-sium (ICS) in Montpellier France, from June 28 to 30.

ICS first established as the intracranial stent meeting has evolved as the interdisciplinary cerebrovascular symposium where MD and PhD experts have the unique opportunity to exchange their views in their fields of interest.

ICS offers the opportunity to learn in a very synthetic manner about the latest scientific developments related to neuro-intervention.

This year the following topics will be covered:- aneuryms computed flow dynamics,- interaction device arterial wall,- stroke biomarkers,- advanced imaging,- genetics of brain vascular malformations,- intrasaccular aneurysmal thrombosis.

Furthermore a full session will be devoted to innovative start-ups in the field of neuro-intervention.This session will bring the latest evolving technologies to the knowledge of the neuro-intervention community and will be followed by a thorough discussion of their daily practice applicability.A parallel session of e-poster presentation will be restricted to the youngest researchers that will have the opportunity to present their latest results.

We are welcoming you in Montpellier.

Professeur Alain BONAFE Professeur Franck NICOUDProfesseur des universités - Praticien hospitalier Professeur Université de Montpellier Service neuroradiologie - Hôpital Gui de Chauliac Place Eugène Bataillon CC51Montpellier MontpellierTél : +33 04.67.33.75.32 Tél :+33 04.67.14.48.46Fax : +33 04.67.33.72.63 Fax : +33 04.6714.93.16a-bonafe@chu-montpellier.fr franck-nicoud@um-montpellier.fr www.math.univ-montp2.fr/~nicoud/

14th Interdisciplinary Cerebrovascular Symposium is compliant with Ethical Medtech

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Synoptic & Faculty

Philippe Bijlenga, Genève, Switzerland

Alain Bonafé, Montpellier

Yacine Boulaftali, Paris

Romain Bourcier, Nantes

Juan R. Cebral, Fairfax, USA

Vincent Costalat, Montpellier Célina Ducroux, Paris

Omer Eker, Lyon

Jean-Luc Falcone, Carouge, Switzerland

Andrea Froelich, Hamburg, Germany

Juhana Frösen, Kuopio, Finland

Grégory Gascou, Montpellier

Matthew Gounis, Worcester, USA

Gabor Janiga, Magdeburg, Germany

Helen Kim, San Francisco, USA

Rob Krams, London, United-Kingdom

Zolt Kulcsar, Zurich, Switzerland

Emmanuelle Le Bars, Montpellier Demetrius K. Lopes, Chicago, USA

Paolo Machi, Genève, Switzerland Charles Majoie, Amsterdam, The Netherlands

Nicola Marchi, Montpellier

Michael Markl, Chicago, USA

Jacques Mercier, Montpellier

Jean-Baptiste Michel, Paris

Satoro Miyawaki, Tokyo, Japan

Joan Montaner, Sevilla, Spain

Charles Mounayer, Limoges

Franck Nicoud, Montpellier

Sakai Nobuyuki, Kobe, Japan

Makoto Ohta, Sendai, Japan

Vitor Pereira, Toronto, Canada

Stéphane Perrey, Montpellier Yi Qian, Macquarie, Australia

Richard Redon, Nantes

Daniel Rûfenacht, Zurich, Switzerland

Ynte Ruigrok, Utrecht, The Netherlands

David A. Steinman, Toronto Canada

Victor Vagne, Montpellier Kristian Valen-Sendstad, Oslo, Norway

Axel Van Rossomme, Charleroi, Belgium

Yiannis Ventikos, London, United-Kingdom

Denis Vivien, Caen

Isabel, Wanke, Zurich, Switzerland

Karim Zouaoui Boudjeltia,Montigny-Le-Tilleul, Belgium

Wednesday June 28 Thursday June 29 Friday June 30

07:30Welcome coffee in the exhibition hall (level 1)

Pasteur Amphitheatre (level 0)08:00 Opening Welcome coffee in the exhibition hall (level 1)08:30

HEMODYNAMICS ISCHEMIC HEMORRAGIC09:0009:3010:00 Coffee break - Demonstration stands (level 1)

Joffre 4 room (level 1)

10:00 Workshop Workshop WorkshopPasteur Amphitheatre (level 0)

10:30HEMODYNAMICS

(continued)ISCHEMIC (continued)

HEMORRAGIC (continued)

11:0011:30

12:00

Lunch break in the exhibition hall

(level 1)

12:30 Lunch break in the exhibition hall

(level 1)13:00 Synthesis and Closing13:3014:00

DEVICE - ARTERIAL WALL INTERACTIONS

INNOVATION & START-UP

14:3015:0015:3016:00 Coffee break (level 1)

Demonstration standsJoffre 4 room (level 1)

Years Workshop16:30 Coffee break (level 1)

Demonstration standsJoffre 4 room (level 1)

Workshop ADVANCED IMAGING17:00 BRAIN VASCULAR

MALFORMATIONS GENETICS

17:3018:0018:20 End of the sessions End of the sessions

Einstein Amphitheatre (level 0)

Crowne Plaza terrace (ground floor)

19:00 Homages 20:00 Cocktail19:15 Schubert concert Jazz concert

chairman Alain Bonafé, Montpellier . . . . . . . . . . . . . . . . . . . . . . . . . . . .

co-chairman Franck Nicoud, Montpellier . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Wednesday

JUNE 28www.ics2017.fr

07:30 Welcome coffee in the exhibition hall (level 1)

Pasteur Amphitheatre (level O)08:00 Opening. Alain Bonafé, Jacques Mercier

HEMODYNAMICS moderators: Franck Nicoud, Vitor Pereira08:30 Towards understanding mechanisms of aneurysm evolution:

connecting experimental, computational and clinical data, Juan R. Cebral

09:00 Consistent prediction of intracranial aneurysm hemodynamics: challenging or not? Kristian Valen-Sendstad09:30 Virtual intracranial stenting research update and perspectives:

modelisation, clinical evaluation and CFD, Vitor Pereira

10:00 Workshop (Joffre 4 room, level 1)10:00 Coffee break - Demonstration stands (level 1)

10:30 Aneurysm flow quantification in patient-specific 3D models, Andrea Froelich

11:00 CFD-based shape optimization of flow diverter stents for patient-specific cases, Gabor Janiga

11:30 In silico and in vivo validation process for new simulation software, Grégory Gascou, Vincent Costalat

12:00 Towards clinical protocols for aneurysm CFD in rupture risk assessment, David A. Steinman

12:30 Lunch break in the exhibition hall (level 1)

DEVICE - ARTERIAL WALL INTERACTIONS moderators: Jean-Baptiste Michel, Isabel Wanke14:00 The role of NF-kB in shear stress and aneurysm formation,

Rob Krams14:30 Role of terminal and anastomotic circulation in the patency of

arteries jailed by flow diverting stents: animal study and clinical findings, Charles Mounayer

15:00 Experimental evaluation of stent retrievers mechanical properties and thrombi removal effectiveness, Paolo Machi

15:30 Aneurysm treatment devices: in situ tissue engineering, Matthew Gounis

16:00 Duality of thrombi, from healing to injury of the wall, Jean-Baptiste Michel

16:30 Workshop (Joffre 4 room, level 1)16:30 Coffee break - Demonstration stands (level 1)

BRAIN VASCULAR MALFORMATIONS GENETICS Swissneuro Foundation moderators: Philippe Bijlenga, Richard Redon17:00 Contribution of NGS-based studies to the genetic architecture of

complex disorder, Richard Redon17:20 Genetic modifiers of disease severity in cerebral cavernous

malformations, Helen Kim17:40 Genetics of moyamoya disease and intracranial stenosis,

Satoro Miyawaki18:00 Current knowledge on genetic risk factors for intracranial

aneurysms, Ynte Ruigrok

18:20 End of the sessions

Einstein Amphitheatre (level 0)19:00 Homages to Patrick Courtheoux and Jean Gabrillargues19:15 Schubert concert: Voyage d’hiver Dalton Baldwin, Philippe Coubes

Included in your registration. Accompanying person fee: 20€.

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Thursday

JUNE 29www.ics2017.fr

08:00 Welcome coffee in the exhibition hall (level 1)

Pasteur Amphitheatre (level O) ISCHEMIC moderators: Denis Vivien, Nicola Marchi08:30 Molecular imaging of neuroinflammation for diagnosis and

prognosis of stroke, Denis Vivien09:00 Biomarkers for stroke: ready for the clinic? Joan Montaner09:30 Impact of downstream microvascular thrombosis on the

benefit of large artery recanalization in acute ischemic stroke: pathophysiology and therapeutic applications, Jean-Baptiste Michel

10:00 Workshop (Joffre 4 room, level 1)10:00 Coffee break - Demonstration stands (level 1)

10:30 An in-vitro investigation of clot properties and their consequences to mechanical thrombectomy, Gillian Gunning, NEURAVI

11:00 THROMBO-NETS study: impact of neutrophil extracellular traps (NETs) composition of thrombi retrieved during endovascular therapy in acute ischemic stroke (AIS) patients on IV t-PA induced thrombolysis, clinical outcome and AIS etiologies, Célina Ducroux

11:20 Association of thrombus perviousness with recanalization and functional outcome in patients with acute ischemic stroke, Charles Majoie

11:40 MR characterization of acute thrombi, Romain Bourcier12:00 ICS meeting 2018 announcement, Philippe Bijlenga

12:10 Lunch break in the exhibition hall (level 1)

14:00 Parallel session: ePosters presentation moderators: Romain Bourcier, Paolo Machi

14:00 Impact of vertebral patency and anatomy on reperfusion success of mechanical thrombectomy in acute basilar artery occlusions: Do we need contralateral flow-arrest? T. Boeckh-Behrens, S. Prothmann, D. Pree, C. Zimmer, S. Wunderlich, J. Kaesmacher

14:07 Input variable selection for quantification of the particle residence time in intracranial aneurysms. E.L. Leemans, B.M.W. Cornelissen, G. Rosalini, C.B.L.M. Majoie, E.T. van Bavel, H.A. Marquering

14:14 T hrombus permeability is based on histological thrombus composition in acute ischemic stroke. M. Berndt, J. Kaesmacher, S. Prothmann, L. Schirmer, C. Zimmer, H. Poppert, T. Boeckh-Behrens

14:21 Multimodal MRI to identify vascular biomarkers: experimental design and modelisation tools. Jérémy Deverdun, Emmanuelle Le Bars, Nicolas Menjot, Liesjet Van Dokkum, Alain Bonafé, Stéphane Chemouny, François Molino

14:28 Hemodynamic transition in stented sidewall aneurysms: from shear to pressure driven regime. P. Bouillot, O. Brina, R. Ouared, M. I. Vargas, K. O. Lovblad, M. Farhat, V. M. Pereira

14:36 Flow measurement with 4D-CTA: method and in-vivo pilot study P. Bouillot, O. Brina, N. Cancelliere, C. Chnafae, P. Machia, M. I. Vargasa, K. O. Lovblada, I. Radovanovicd, T. Kringsc, D. A. Steinmane, V. M. Pereira

14:43 3D phase contrast MRI: partial volume correction for robust blood flow quantification in small intracranial vessels. P. Bouillot, B. M. A. Delattre, O. Brina, R. Ouareda, M. Farhat, C. Chnafa, D. A. Steinman, K. O. Lovblad, V. M. Pereira, M. I. Vargas

14:50 Assessment of Formation of Embolized Coil by Changing Catheter Position Using FEM. Fujimura Soichiro, Takao Hiroyuki, Suzuki Takashi, Uchiyama Yuya, Tanaka Kazutoshi, Ishibashi Toshihiro, Dahmani Chihebeddine, Mamori Hiroya, Murayama Yuichi, Yamamoto Makoto

14:57 Hemodynamic Evaluation of Rupture Prediction for Cerebral Aneurysms by Computational Fluid Dynamics. Y. Uchiyama, H. Takao, T. Suzuki, S. Fujimura, K. Tanaka, T. Ishibashi,H. Mamori, Y. Murayama, M. Yamamoto

15:04 Investigation to Determine the Hemodynamic Factor or Occurrence of Thin-walled Regions in Unruptured Cerebral Aneurysms by CFD. Kazutoshi Tanaka, H. Takao, T.Suzuki, T. Suzuki, S. Fujimura, H.Mamori, Y. Murayama, M. Yamamoto

15:11 Evaluation of the common viscosity assumption for patient-specific hemodynamic simulations of intracranial aneurysms. Takashi Suzuki, Hiroyuki Takao, Tomoaki Suzuki, Shunsuke Hataoka, Tomonobu Kodama, Soichiro Fujimura, Chihebeddine Dahmani, Toshihiro Ishibashi, Yuichi Murayama, Hideki Yamamoto, Makoto Yamamoto

15:18 Comparing the Sphere and a conventional flow-diverter device: The virtual treatment of cerebral bifurcation aneurysms. Yiannis Ventikos, J. Frederick Cornhill, Thomas Peach

15:25 Neutrophil to Lymphocyte Ratio and leukocyte subtype counts in acute stroke are predictive of outcome independently of infections. Aurora Semerano, Davide Strambo, Gianvito Martino, Giancarlo Comi, Luisa Roveri, Marco Bacigaluppi

15:32 The influence of anatomical variations in the Circle of Willis on aneurysmal parent artery flow profiles. B.M.W. Cornelissen, M.E. Sprengers, J.J. Schneiders, P. van Ooij, C.H. Slump, H.A. Marquering,C.B.L.M. Majoie

15:39 Impact of DSA reconstruction kernels on segmentation and blood flow results in cerebral aneurysms. P. Berg, S. Saalfeld, S. Vo, G. Janiga, O. Beuing

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Friday

JUNE 30www.ics2017.fr

08:00 Welcome coffee in the exhibition hall (level 1)

HEMORRAGIC: intrasaccular thrombosis moderators: Karim Zouaoui Boudjeltia, Sakai Nobuyuki08:30 Aneurysm spatial orientation and thrombosis,

Axel Van Rossomme09:00 Platelet - arterial wall interaction, Yacine Boulaftali09:30 Intra saccular hemostasis changes following flow diverter

placement, Omer Eker

10:00 Workshop (Joffre 4 room, level 1)10:00 Coffee break - Demonstration stands (level 1)

10:30 Simulation of intrasaccular thrombosis, Jean-Luc Falcone10:50 Estimation for the outcomes of flow diverter treatment

intracranial aneurysms:FD deployment process (compaction), FD selection (size and type), analysis successful/unsuccessful, clot formation process, and CFD simulation results, Yi Qian

11:20 Integrated treatment planning for cerebral aneurysms: Deployment, haemodynamics and thrombosis for flow diversion devices, Yiannis Ventikos

11:50 Impact of stents and coils on thrombus biology, Jean-Baptiste Michel

12:20 Pharmacological therapy to reduce flow-driven aneurysm wall remodeling, growth and eventual risk of rupture, Juhana Frösen

12:50 Synthesis and closing Alain Bonafé, Franck Nicoud

15:46 Analysis of relationship between gross pathology of the aneurysm wall and local pressure of the aneurysm inner wall. Takeshi Yanagisawa, Hiroyuki Takao, Takashi Suzuki, Rokuya Tanikawa, Hiroyasu Kamiyama, Yuichi Hirose, Makoto Yamamoto, Yuichi Murayama

15:53 Impact of stent-induced vessel deformation on the hemody-namic of intracranial aneurysms. S. Vo, P. Berg, G. Janiga, O. Beuing

INNOVATION & START-UP moderator: Vincent Costalat14:00 Start-up #1 IN STENT, Franz Bozsak14:30 Start-up #2 SIM & CURE, Mathieu Sanchez15:00 Start-up #3 BIOMODEX, Thomas Marchand15:30 Start-up #4 SMARTWISEAB, Johan Lundberg

16:00 Years Workshop (Joffre 4 room, level 1) Introducing the Lucid System: The future of Large Vessel Stroke

Detection16:00 Coffee break - Demonstration stands (level 1)

ADVANCED IMAGING moderators: Emmanuelle Le Bars, Makoto Ohta16:30 Assessment of In-Vivo cerebrovascular hemodynamics with 4D

flow MRI, Michael Markl17:00 NIRS-TDCS as a potential new technic to screen for ischemic

stroke tissue: ELEVANT PROJECT, Victor Vagne, Stéphane Perrey17:30 Intravascular imaging will change intracranial stenting,

Demetrius K. Lopes18:00 Phase contrast MRI segmentation methods for flow

measurements, Omer Eker

18:30 End of the sessions

20:00 Get together cocktail. Crowne Plaza terrace (ground floor) 190 rue d’Argencourt, Montpellier (5 min. walking distance) Jazz concert and cocktail. Duo Fumar Phil Furneaux (saxophonist) and Krys Markowski (piano)

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Registration & information desk hoursWednesday June 28 07:15 - 18:30Thursday June 29 07:45 - 18:30Friday June 30 07:45 - 13:00

ORGANIZATIONProject managerStéphanie Meyer +33 646 10 48 26 smeyer@divine-id.comRegistration & accommodationMargaux Gabrielli +33 620 76 78 05 mgabrielli@divine-id.comExecutive managerVérane Bergeron Moreau +33 621 78 87 16 vbergeron@divine-id.com

divine [id] - 17, rue Venture - 13001 Marseille - Francewww.divine-id.com

EXHIBITIONINFO

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Exhibition hoursWednesday June 28 07:30 - 18:30Thursday June 29 08:00 - 18:30Friday June 30 08:00 - 10:30

ACKNOWLEDGEMENTS 2017

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REFERENCES: 1. Internal testing TRNV1191-Performance Evaluation of Pipeline™ Flex Embolization Device with Shield Technology™ - September 2014.

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Les informations contenues dans cette annonce sont destinées au public internationalde professionnels de santé assistant au ICS à Montpellier du 28 au 30 juin 2017 et ne sontpas spécifi quement destinées aux professionnels de santé exerçant en France.Les mentions obligatoires sont disponibles sur demande.

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