JOURNAL OF IMMUNOLOGY VOL. 172, NO. 1, JANUARY 1; 2004

IN THIS ISSUE 1-2LETTERS TO THE EDITOR Dendritic Cell Differentiation Antonio Curti, Elisa Ferri, Simona Pandolfi, Alessandro Isidori, Roberto M. Lemoli, Marc Dauer, Katharina Schad, Jan Herten, Stefan Endres, and Andreas Eigler

3-4

Signaling and Cell Surface Expression of µH Chains in the Absence of Light Chains Daniel Corcos, Hans-Martin Jäck, Wolfgang Schuh, Silke Meister, and Edith Roth

4-5

BRIEF REVIEWS Regulation of Leukocyte Transmigration: Cell Surface Interactions and Signaling Events Yuan Liu, Sunil K. Shaw, Shuo Ma, Lin Yang, Francis W. Luscinskas, and Charles A. Parkos

7-13

CUTTING EDGE Cutting Edge: IL-7-Dependent Homeostatic Proliferation of CD8+ T Cells in Neonatal Mice Allows the Generation of Long-Lived Natural Memory T Cells Thomas Schüler, Günter J. Hämmerling, and Bernd Arnold

15-19

Cutting Edge: An Endogenous Pathway to Systemic Inflammatory Response Syndrome (SIRS)-Like Reactions through Toll-Like Receptor 4 Geoffrey B. Johnson, Gregory J. Brunn, and Jeffrey L. Platt

20-24

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION Expression of Preproinsulin-2 Gene Shapes the Immune Response to Preproinsulin in Normal Mice Béatrice Faideau, Jean-Paul Briand, Chantal Lotton, Isabelle Tardivel, Philippe Halbout, Jacques Jami, John F. Elliott, Patricia Krief, Sylviane Muller, Christian Boitard, and Jean-Claude Carel

25-33

B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions Patricia A. Taylor, Christopher J. Lees, Sylvie Fournier, James P. Allison, Arlene H. Sharpe, and Bruce R. Blazar

34-39

A Role for TCR Affinity in Regulating Naive T Cell Homeostasis William C. Kieper, J. Theodore Burghardt, and Charles D. Surh

40-44

Essential Role for Neutrophil Recruitment to the Liver in Concanavalin A-Induced Hepatitis Claudine S. Bonder, Maureen N. Ajuebor, Lori D. Zbytnuik, Paul Kubes, and Mark G. Swain

45-53

Sensing Environmental Lipids by Dendritic Cell Modulates Its Function Frédéric Coutant, Sophie Agaugué, Laure Perrin-Cocon, Patrice André, and Vincent Lotteau

54-60

Sustained IL-12 Signaling Is Required for Th1 Development Veronica Athie-Morales, Hermelijn H. Smits, Doreen A. Cantrell, and Catharien M. U. Hilkens

61-69

A CD91-Positive Subset of CD11c+ Blood Dendritic Cells: 70-78

Characterization of the APC that Functions to Enhance Adaptive Immune Responses against CD91-Targeted Antigens Justin P. Hart, Michael D. Gunn, and Salvatore V. Pizzo Rosmarinic Acid Induces p56lck-Dependent Apoptosis in Jurkat and Peripheral T Cells via Mitochondrial Pathway Independent from Fas/Fas Ligand Interaction Yun-Gyoung Hur, Yungdae Yun, and Jonghwa Won

79-87

The IL-12 Signature: NK Cell Terminal CD56+high Stage and Effector Functions Matthew J. Loza and Bice Perussia

88-96

The Susceptibility to Experimental Myasthenia Gravis of STAT6-/- and STAT4-/- BALB/c Mice Suggests a Pathogenic Role of Th1 Cells Wei Wang, Norma S. Ostlie, Bianca M. Conti-Fine, and Monica Milani

97-103

Activation of Resting Human Primary T Cells with Chimeric Receptors: Costimulation from CD28, Inducible Costimulator, CD134, and CD137 in Series with Signals from the TCR Chain Helene M. Finney, Arne N. Akbar, and Alastair D. G. Lawson

104-113

Up-Regulation of Hlx in Immature Th Cells Induces IFN- Expression Wei-ping Zheng, Qian Zhao, Xinyan Zhao, Baiyong Li, Mike Hubank, David G. Schatz, and Richard A. Flavell

114-122

NK Cell TRAIL Eliminates Immature Dendritic Cells In Vivo and Limits Dendritic Cell Vaccination Efficacy Yoshihiro Hayakawa, Valentina Screpanti, Hideo Yagita, Alf Grandien, Hans-Gustaf Ljunggren, Mark J. Smyth, and Benedict J. Chambers

123-129

NK Cells Regulate CD8+ T Cell Effector Function in Response to an Intracellular Pathogen Ramakrishna Vankayalapati, Peter Klucar, Benjamin Wizel, Stephen E. Weis, Buka Samten, Hassan Safi, Homayoun Shams, and Peter F. Barnes

130-137

APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA Kerstin N. Schmidt, Beatrice Leung, Mandy Kwong, Kol A. Zarember, Sanjeev Satyal, Tony A. Navas, Fay Wang, and Paul J. Godowski

138-143

Analysis of Gene Expression and Ig Transcription in PU.1/Spi-B-Deficient Progenitor B Cell Lines Brock L. Schweitzer and Rodney P. DeKoter

144-154

Fully Functional HLA B27-Restricted CD4+ as well as CD8+ T Cell Responses in TCR Transgenic Mice Matthew Roddis, Robert W. Carter, Mei-Yi Sun, Thomas Weissensteiner, Andrew J. McMichael, Paul Bowness, and Helen C. Bodmer

155-161

Melanoma-Reactive Class I-Restricted Cytotoxic T Cell Clones Are Stimulated by Dendritic Cells Loaded with Synthetic Peptides, but Fail to Respond to Dendritic Cells Pulsed with Melanoma-Derived Heat Shock Proteins In Vitro Kristina Fleischer, Burkhard Schmidt, Wolfgang Kastenmüller, Dirk H. Busch, Ingo Drexler, Gerd Sutter, Michael Heike, Christian Peschel, and Helga Bernhard

162-169

A Repressor of GATA-Mediated Negative Feedback Mechanism of T Cell Activation

170-177

Shi-Chuen Miaw, Bok Yun Kang, Ian Alexander White, and I-Cheng Ho Tolerogenic APC Generate CD8+ T Regulatory Cells That Modulate Pulmonary Interstitial Fibrosis Jie Zhang-Hoover and Joan Stein-Streilein

178-185

CD1-Dependent Regulation of Chronic Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis Anna Teige, Ingrid Teige, Shahram Lavasani, Robert Bockermann, Emma Mondoc, Rikard Holmdahl, and Shohreh Issazadeh-Navikas

186-194

Cognate B Cell Signaling via MHC Class II: Differential Regulation of B Cell Antigen Receptor and MHC Class II/Ig- Signaling by CD22 David M. Mills, John C. Stolpa, and John C. Cambier

195-201

Inducible Heat Shock Protein 70 Promotes Myelin Autoantigen Presentation by the HLA Class II Marcin P. Mycko, Hanna Cwiklinska, Jacek Szymanski, Bozena Szymanska, Grzegorz Kudla, Lukasz Kilianek, Artur Odyniec, Celia F. Brosnan, and Krzysztof W. Selmaj

202-213

Regulation of CD103 Expression by CD8+ T Cells Responding to Renal Allografts Donghua Wang, Rongwen Yuan, Ye Feng, Riham El-Asady, Donna L. Farber, Ronald E. Gress, Philip J. Lucas, and Gregg A. Hadley

214-221

Superantigen Stimulation Reveals the Contribution of Lck to Negative Regulation of T Cell Activation Gabriel Criado and Joaquín Madrenas

222-230

Role of TNF Receptor-Associated Factor 3 in the CD40 Signaling by Production of Reactive Oxygen Species through Association with p40phox, a Cytosolic Subunit of Nicotinamide Adenine Dinucleotide Phosphate Oxidase Yun Jung Ha and Jong Ran Lee

231-239

Effects of T Cell Frequency and Graft Size on Transplant Outcome in Mice Chunshui He, Soren Schenk, Qiwei Zhang, Anna Valujskikh, Jörg Bayer, Robert L. Fairchild, and Peter S. Heeger

240-247

T Cell Clonal Conditioning: A Phase Occurring Early after Antigen Presentation but before Clonal Expansion Is Impacted by Toll-Like Receptor Stimulation Joseph R. Maxwell, Robert J. Rossi, Stephen J. McSorley, and Anthony T. Vella

248-259

Human Intestinal Fibroblasts Prevent Apoptosis in Human Intestinal Mast Cells by a Mechanism Independent of Stem Cell Factor, IL-3, IL-4, and Nerve Growth Factor Gernot Sellge, Axel Lorentz, Thomas Gebhardt, Francesca Levi-Schaffer, Hueseyin Bektas, Michael P. Manns, Detlef Schuppan, and Stephan C. Bischoff

260-267

CXCR1+CD4+ T Cells in Human Allergic Disease James N. Francis, Mikila R. Jacobson, Clare M. Lloyd, Ian Sabroe, Stephen R. Durham, and Stephen J. Till

268-273

Colorectal Cancer Cells Induce Lymphocyte Apoptosis by an Endothelial Monocyte-Activating Polypeptide-II-Dependent Mechanism J. Clifford Murray, Peter Symonds, Wynne Ward, Mary Huggins, Anna

274-281

Tiga, Katherine Rice, Yee M. Heng, Ian Todd, and R. Adrian Robins The 11 and E7 Integrins Define a Subset of Dendritic Cells in Peripheral Lymph Nodes with Unique Adhesive and Antigen Uptake Properties Jonathan T. Pribila, Andrea A. Itano, Kristen L. Mueller, and Yoji Shimizu

282-291

Dendritic Cell Maturation Controls Adhesion, Synapse Formation, and the Duration of the Interactions with Naive T Lymphocytes Federica Benvenuti, Cecile Lagaudrière-Gesbert, Isabelle Grandjean, Carolina Jancic, Claire Hivroz, Alain Trautmann, Olivier Lantz, and Sebastian Amigorena

292-301

Dermal Enhancement: Bacterial Products on Intact Skin Induce and Augment Organ-Specific Autoimmune Disease D. Sean Riminton, Rama Kandasamy, Danijela Dravec, Antony Basten, and Alan G. Baxter

302-309

Pulmonary Tumors Inefficiently Prime Tumor-Specific T Cells Leigh A. O’Mara and Paul M. Allen

310-317

MOLECULAR AND STRUCTURAL IMMUNOLOGY Dexamethasone Inhibits IL-12p40 Production in Lipopolysaccharide-Stimulated Human Monocytic Cells by Down-Regulating the Activity of c-Jun N-Terminal Kinase, the Activation Protein-1, and NF-B Transcription Factors Wei Ma, Katrina Gee, Wilfred Lim, Kelly Chambers, Jonathan B. Angel, Maya Kozlowski, and Ashok Kumar

318-330

Two Distinct Waves of Membrane-Proximal B Cell Antigen Receptor Signaling Differentially Regulated by Src Homology 2-Containing Inositol Polyphosphate 5-Phosphatase Allyson K. Krahn, Kewei Ma, Sen Hou, Vincent Duronio, and Aaron J. Marshall

331-339

Partitioning of Rearranged Ig Genes by Mutation Analysis Demonstrates D-D Fusion and V Gene Replacement in the Expressed Human Repertoire Andrew M. Collins, Masashi Ikutani, Daniela Puiu, Gregory A. Buck, Aradhita Nadkarni, and Bruno Gaeta

340-348

A Functional C5a Anaphylatoxin Receptor in a Teleost Species M. Claire H. Holland and John D. Lambris

349-355

Domain Shuffling Has Been the Main Mechanism Forming New Hominoid Killer Cell Ig-Like Receptors Raja Rajalingam, Peter Parham, and Laurent Abi-Rached

356-369

The Tetraspanin CD81 Is Necessary for Partitioning of Coligated CD19/CD21-B Cell Antigen Receptor Complexes into Signaling-Active Lipid Rafts Anu Cherukuri, Tsipi Shoham, Hae Won Sohn, Shoshana Levy, Stephen Brooks, Robert Carter, and Susan K. Pierce

370-380

Molecular Characterization of a Putative Antiretroviral Transcriptional Factor, OTK18 Kimberly A. Carlson, Gary Leisman, Jenae Limoges, Garrett D. Pohlman, Masahide Horiba, James Buescher, Howard E. Gendelman, and Tsuneya Ikezu

381-391

DEFENSE Herpes Simplex Virus-Specific CD8+ T Cells Can Clear Established 392-397

Lytic Infections from Skin and Nerves and Can Partially Limit the Early Spread of Virus after Cutaneous Inoculation Allison van Lint, Margaret Ayers, Andrew G. Brooks, Richard M. Coles, William R. Heath, and Francis R. Carbone Essential Contribution of Monocyte Chemoattractant Protein-1/C-C Chemokine Ligand-2 to Resolution and Repair Processes in Acute Bacterial Pneumonia Hideaki Amano, Kounosuke Morimoto, Masachika Senba, Hui Wang, Yuko Ishida, Atsushi Kumatori, Hiroyuki Yoshimine, Kazunori Oishi, Naofumi Mukaida, and Tsuyoshi Nagatake

398-409

Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin (Cdt): Evidence That the Holotoxin Is Composed of Three Subunits: CdtA, CdtB, and CdtC Bruce J. Shenker, Dave Besack, Terry McKay, Lisa Pankoski, Ali Zekavat, and Donald R. Demuth

410-417

Localization of Cystic Fibrosis Transmembrane Conductance Regulator to Lipid Rafts of Epithelial Cells Is Required for Pseudomonas aeruginosa-Induced Cellular Activation Michael P. Kowalski and Gerald B. Pier

418-425

Organism-Specific Neutrophil-Endothelial Cell Interactions in Response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus Jessica G. Moreland, Gail Bailey, William M. Nauseef, and Jerrold P. Weiss

426-432

Critical Role of T Cell-Dependent Serum Antibody, but Not the Gut-Associated Lymphoid Tissue, for Surviving Acute Mucosal Infection with Citrobacter rodentium, an Attaching and Effacing Pathogen Lynn Bry and Michael B. Brenner

433-441

Redox-Sensing Release of Human Thioredoxin from T Lymphocytes with Negative Feedback Loops Norihiko Kondo, Yasuyuki Ishii, Yong-Won Kwon, Masaki Tanito, Hiroyuki Horita, Yumiko Nishinaka, Hajime Nakamura, and Junji Yodoi

442-448

Modulation of the Phosphoinositide 3-Kinase Pathway Alters Innate Resistance to Polymicrobial Sepsis David L. Williams, Chuanfu Li, Tuanzhu Ha, Tammy Ozment-Skelton, John H. Kalbfleisch, Johanna Preiszner, Lynne Brooks, Kevin Breuel, and John B. Schweitzer

449-456

STAT1 Plays a Critical Role in the Regulation of Antimicrobial Effector Mechanisms, but Not in the Development of Th1-Type Responses during Toxoplasmosis Linda A. Lieberman, Monica Banica, Steven L. Reiner, and Christopher A. Hunter

457-463

Hyperactivation of STAT3 Is Involved in Abnormal Differentiation of Dendritic Cells in Cancer Yulia Nefedova, Mei Huang, Sergei Kusmartsev, Raka Bhattacharya, Pingyan Cheng, Raoul Salup, Richard Jove, and Dmitry Gabrilovich

464-474

Dendritic Cells from Malaria-Infected Mice Are Fully Functional APC James A. Perry, Adam Rush, Randy J. Wilson, Christine S. Olver, and Anne C. Avery

475-482

Conserved Hierarchy of Helper T Cell Responses in a Chimpanzee during Primary and Secondary Hepatitis C Virus Infections Naglaa H. Shoukry, John Sidney, Alessandro Sette, and Christopher M. Walker

483-492

Galectin-3 Mediates IL-4-Induced Survival and Differentiation of B Cells: Functional Cross-Talk and Implications during Trypanosoma cruzi Infection Eva V. Acosta-Rodríguez, Carolina L. Montes, Claudia C. Motrán, Elina I. Zuniga, Fu-Tong Liu, Gabriel A. Rabinovich, and Adriana Gruppi

493-502

Improved Effector Activity and Memory CD8 T Cell Development by IL-2 Expression during Experimental Respiratory Syncytial Virus Infection Jun Chang, So Young Choi, Hyun Tak Jin, Young Chul Sung, and Thomas J. Braciale

503-508

Neutrophil Serine Proteinases Cleave Bacterial Flagellin, Abrogating Its Host Response-Inducing Activity Yolanda S. López-Boado, Marcia Espinola, Scott Bahr, and Abderrazzaq Belaaouaj

509-515

Murine -Herpesvirus-68-Induced IL-12 Contributes to the Control of Latent Viral Burden, but Also Contributes to Viral-Mediated Leukocytosis Sherine F. Elsawa and Kenneth L. Bost

516-524

IL-23 Induces Stronger Sustained CTL and Th1 Immune Responses Than IL-12 in Hepatitis C Virus Envelope Protein 2 DNA Immunization Sang-Jun Ha, Doo-Jin Kim, Kwan-Hyuck Baek, Yung-Dae Yun, and Young-Chul Sung

525-531

Differential Regulation of IgG Anti-Capsular Polysaccharide and Antiprotein Responses to Intact Streptococcus pneumoniae in the Presence of Cognate CD4+ T Cell Help Abdul Q. Khan, Andrew Lees, and Clifford M. Snapper

532-539

INFLAMMATION Proteolytic Regulation of the Urokinase Receptor/CD87 on Monocytic Cells by Neutrophil Elastase and Cathepsin G Nathalie Beaufort, Dominique Leduc, Jean-Claude Rousselle, Viktor Magdolen, Thomas Luther, Abdelkader Namane, Michel Chignard, and Dominique Pidard

540-549

IFN-Inducible Protein 10/CXC Chemokine Ligand 10-Independent Induction of Experimental Autoimmune Encephalomyelitis Robyn S. Klein, Leonid Izikson, Terry Means, Hilary D. Gibson, Eugene Lin, Raymond A. Sobel, Howard L. Weiner, and Andrew D. Luster

550-559

Intracellular Regulation of Fas-Induced Apoptosis in Human Fibroblasts by Extracellular Factors and Cycloheximide Begoña Santiago, María Galindo, Guillermo Palao, and José L. Pablos

560-566

Signal Transducer and Activator of Transcription 3 Is the Dominant Mediator of the Anti-Inflammatory Effects of IL-10 in Human Macrophages Lynn Williams, Laura Bradley, Alexandra Smith, and Brian Foxwell

567-576

Membrane-Associated IL-1 Contributes to Chronic Synovitis and 577-584

Cartilage Destruction in Human IL-1 Transgenic Mice Yasuo Niki, Harumoto Yamada, Toshiyuki Kikuchi, Yoshiaki Toyama, Hideo Matsumoto, Kyosuke Fujikawa, and Norihiro Tada Soluble Fractalkine Prevents Monocyte Chemoattractant Protein-1-Induced Monocyte Migration via Inhibition of Stress-Activated Protein Kinase 2/p38 and Matrix Metalloproteinase Activities Sébastien Vitale, Annie Schmid-Alliana, Véronique Breuil, Manuel Pomeranz, Marie-Ange Millet, Bernard Rossi, and Heidy Schmid-Antomarchi

585-592

Neutralizing Endogenous IL-6 Renders Mast Cells of the MCT Type from Lung, but Not the MCTC Type from Skin and Lung, Susceptible to Human Recombinant IL-4-Induced Apoptosis Carole A. Oskeritzian, Wei Zhao, Andrea L. Pozez, Neri M. Cohen, Margaret Grimes, and Lawrence B. Schwartz

593-600

Cytoskeletal Reorganization Internalizes Multiple Transient Receptor Potential Channels and Blocks Calcium Entry into Human Neutrophils Kiyoshi Itagaki, Kolenkode B. Kannan, Brij B. Singh, and Carl J. Hauser

601-607

Intercellular Adhesion Molecule-1 Mediates Cellular Cross-Talk between Parenchymal and Immune Cells after Lipopolysaccharide Neutralization Jin-Hwa Lee, Lorenzo Del Sorbo, Stefan Uhlig, Giuliana A. Porro, Thomas Whitehead, Stefanos Voglis, Mingyao Liu, Arthur S. Slutsky, and Haibo Zhang

608-616

CLINICAL IMMUNOLOGY Corticosteroids Regulate Epithelial Cell Differentiation and Hassall Body Formation in the Human Thymus Laura P. Hale and M. Louise Markert

617-624

Impaired Clearance of Apoptotic Cells Induces the Activation of Autoreactive Anti-Sm Marginal Zone and B-1 B Cells Ye Qian, Hongsheng Wang, and Stephen H. Clarke

625-635

Gene Expression Profiling Provides Insight into the Pathophysiology of Chronic Granulomatous Disease Scott D. Kobayashi, Jovanka M. Voyich, Kevin R. Braughton, Adeline R. Whitney, William M. Nauseef, Harry L. Malech, and Frank R. DeLeo

636-643

Determinants of Antileukemia Effects of Allogeneic NK Cells Wing Leung, Rekha Iyengar, Victoria Turner, Peter Lang, Peter Bader, Paul Conn, Dietrich Niethammer, and Rupert Handgretinger

644-650

A Novel Mechanism of Alternative Promoter and Splicing Regulates the Epitope Generation of Tumor Antigen CML66-L Yan Yan, Leuyen Phan, Fan Yang, Moshe Talpaz, Yu Yang, Zeyu Xiong, Bernard Ng, Nikolai A. Timchenko, Catherine J. Wu, Jerome Ritz, Hong Wang, and Xiao-Feng Yang

651-660

Antibody Cross-Reactivity between Myelin Oligodendrocyte Glycoprotein and the Milk Protein Butyrophilin in Multiple Sclerosis Johannes Guggenmos, Anna S. Schubart, Sherry Ogg, Magnus Andersson, Tomas Olsson, Ian H. Mather, and Christopher Linington

661-668

Distortion of the Self-Reactive IgG Antibody Repertoire in Multiple Sclerosis as a New Diagnostic Tool

669-678

Didier Lefranc, Lionel Almeras, Sylvain Dubucquoi, Jérôme de Seze, Patrick Vermersch, and Lionel Prin CD4+ T Cells Mediate Murine Syngeneic Graft-versus-Host Disease-Associated Colitis J. Scott Bryson, Lining Zhang, Sarah W. Goes, C. Darrell Jennings, Betty E. Caywood, Sonia L. Carlson, and Alan M. Kaplan

679-687

NF-B p65 Antagonizes IL-4 Induction by c-maf in Minimal Change Nephrotic Syndrome Asta Valanciuté, Sabine le Gouvello, Brigitte Solhonne, André Pawlak, Philippe Grimbert, Luc Lyonnet, Sophie Hue, Philippe Lang, Philippe Remy, Rémy Salomon, Albert Bensman, Georges Guellaën, and Djillali Sahali

688-698

Thymic Selection and Peripheral Activation of CD8 T Cells by the Same Class I MHC/Peptide Complex Justine D. Mintern, Madelon M. Maurice, Hidde L. Ploegh, and Eckart Schott

699-708

A Major B Cell Epitope Present on the Apoptotic but Not the Intact Form of the U1-70-kDa Ribonucleoprotein Autoantigen Eric L. Greidinger, Mark F. Foecking, Joseph Magee, Linda Wilson, Sriya Ranatunga, Robert A. Ortmann, and Robert W. Hoffman

709-716

CORRECTIONS CD8+ and CD11b+ Dendritic Cell-Restricted MHC Class II Controls Th1 CD4+ T Cell Immunity Maria P. Lemos, Lian Fan, David Lo, and Terri M. Laufer

717

Another View of T Cell Antigen Recognition: Cooperative Engagement of Glycolipid Antigens by Va14Ja18 Natural TCR Aleksandar K. Stanic, R. Shashidharamurthy, Jelena S. Bezbradica, Naoto Matsuki, Yoshitaka Yoshimura, Sachiko Miyake, Eun Young Choi, Todd D. Schell, Luc Van Kaer, Satvir S. Tevethia, Derry C. Roopoenian, Takashi Yamamura, and Sebastian Joyce

717

Microglia-Mediated Nitric Oxide Cytotoxicity of T Cells Following Amyloid Peptide Presentation to Th1 Cells Alon Monsonego, Jaime Imitola, Victor Zota, Takatoku Oida, and Howard L. Weiner

717

Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25-CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene Regulatory T Cells Koji Uraushihara, Takanori Kanai, Kwibeom Ko, Teruji Totsuka, Shin Makita, Ryoichi Iiyama, Tetsuya Nakamura, and Mamoru Watanabe

717

VOL. 172, NO. 2 , JANUARY 15; 2004 IN THIS ISSUE 745-746 CUTTING EDGE Cutting Edge: Anthrax Lethal Toxin Inhibits Activation of IFN-Regulatory Factor 3 by Lipopolysaccharide Oanh Dang, Lorena Navarro, Keith Anderson, and Michael David

747-751

Cutting Edge: NF-B2 Is a Negative Regulator of Dendritic Cell Function Kendra Speirs, Linda Lieberman, Jorge Caamano, Christopher A. Hunter, and Phillip Scott

752-756

Cutting Edge: Novel Priming of Tumor-Specific Immunity by NKG2D-Triggered NK Cell-Mediated Tumor Rejection and Th1-Independent CD4+ T Cell Pathway Jennifer A. Westwood, Janice M. Kelly, Jane E. Tanner, Michael H. Kershaw, Mark J. Smyth, and Yoshihiro Hayakawa

757-761

Cutting Edge: BAFF Regulates CD21/35 and CD23 Expression Independent of Its B Cell Survival Function Leonid Gorelik, Anne H. Cutler, Greg Thill, Steven D. Miklasz, Dianna E. Shea, Christine Ambrose, Sarah A. Bixler, Lihe Su, Martin L. Scott, and Susan L. Kalled

762-766

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION Differential Role of CCR2 in Islet and Heart Allograft Rejection: Tissue Specificity of Chemokine/Chemokine Receptor Function In Vivo Reza Abdi, Terry K. Means, Toshiro Ito, Rex Neal Smith, Nader Najafian, Mollie Jurewicz, Vaja Tchipachvili, Israel Charo, Hugh Auchincloss, Jr., Mohamed H. Sayegh, and Andrew D. Luster

767-775

Enhanced Priming of Antigen-Specific CTLs In Vivo by Embryonic Stem Cell-Derived Dendritic Cells Expressing Chemokine Along with Antigenic Protein: Application to Antitumor Vaccination Hidetake Matsuyoshi, Satoru Senju, Shinya Hirata, Yoshihiro Yoshitake, Yasushi Uemura, and Yasuharu Nishimura

776-786

CD7 and CD28 Are Required for Murine CD4+CD25+ Regulatory T Cell Homeostasis and Prevention of Thyroiditis Gregory D. Sempowski, Scott J. Cross, Craig S. Heinly, Richard M. Scearce, and Barton F. Haynes

787-794

TCR-Independent and Caspase-Independent Apoptosis of Murine Thymocytes by CD24 Cross-Linking Kyeong Cheon Jung, Weon Seo Park, Hae Jung Kim, Eun Young Choi, Myeong-Cherl Kook, Han-Woong Lee, and Youngmee Bae

795-802

Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T Cells Kalaya Attanavanich and John F. Kearney

803-811

TNF Deficiency Fails to Protect BAFF Transgenic Mice against Autoimmunity and Reveals a Predisposition to B Cell Lymphoma Marcel Batten, Carrie Fletcher, Lai Guan Ng, Joanna Groom, Julie Wheway, Yacine Laâbi, Xiaoguan Xin, Pascal Schneider, Jurg Tschopp, Charles R. Mackay, and Fabienne Mackay

812-822

Progressive Surface B Cell Antigen Receptor Down-Regulation Accompanies Efficient Development of Antinuclear Antigen B Cells to Mature, Follicular Phenotype Lynn Heltemes-Harris, Xiaohe Liu, and Tim Manser

823-833

TGF-1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice Kazuhiko Nakamura, Atsushi Kitani, Ivan Fuss, Aasta Pedersen, Naohiko Harada, Hajime Nawata, and Warren Strober

834-842

Ephrin-A1 Suppresses Th2 Cell Activation and Provides a Regulatory Link to Lung Epithelial Cells Jan G. Wohlfahrt, Christian Karagiannidis, Steffen Kunzmann, Michelle M. Epstein, Werner Kempf, Kurt Blaser, and Carsten B. Schmidt-Weber

843-850

Central Tolerance to Self-Antigen Expressed by Cortical Epithelial 851-856

Cells Dita Mayerova and Kristin A. Hogquist Dendritic Cell Immunization Route Determines CD8+ T Cell Trafficking to Inflamed Skin: Role for Tissue Microenvironment and Dendritic Cells in Establishment of T Cell-Homing Subsets Jan C. Dudda, Jan C. Simon, and Stefan Martin

857-863

Turnover and Proliferation of NK Cells in Steady State and Lymphopenic Conditions Amanda M. Jamieson, Patricia Isnard, Jeffrey R. Dorfman, Mark C. Coles, and David H. Raulet

864-870

MHC Class II Molecules Play a Role in the Selection of Autoreactive Class I-Restricted CD8 T Cells That Are Essential Contributors to Type 1 Diabetes Development in Nonobese Diabetic Mice David V. Serreze, T. Matthew Holl, Michele P. Marron, Robert T. Graser, Ellis A. Johnson, Caroline Choisy-Rossi, Robyn M. Slattery, Scott M. Lieberman, and Teresa P. DiLorenzo

871-879

Innate Immune Discrimination of Apoptotic Cells: Repression of Proinflammatory Macrophage Transcription Is Coupled Directly to Specific Recognition Marija Cvetanovic and David S. Ucker

880-889

Dual Role of CCR2 during Initiation and Progression of Collagen-Induced Arthritis: Evidence for Regulatory Activity of CCR2+ T Cells Hilke Brühl, Josef Cihak, Martin A. Schneider, Jirí Plachy, Tamara Rupp, Isabell Wenzel, Mehdi Shakarami, Stefan Milz, Joachim W. Ellwart, Manfred Stangassinger, Detlef Schlöndorff, and Matthias Mack

890-898

NKp44 Triggers NK Cell Activation through DAP12 Association That Is Not Influenced by a Putative Cytoplasmic Inhibitory Sequence Kerry S. Campbell, Sei-ichi Yusa, Akiko Kikuchi-Maki, and Tracey L. Catina

899-906

Invariant Chain and the MHC Class II Cytoplasmic Domains Regulate Localization of MHC Class II Molecules to Lipid Rafts in Tumor Cell-Based Vaccines Brian P. Dolan, Timothy P. Phelan, Dan Ilkovitch, Ling Qi, William F. Wade, Terri M. Laufer, and Suzanne Ostrand-Rosenberg

907-914

An Altered Self-Peptide with Superagonist Activity Blocks a CD8-Mediated Mouse Model of Type 1 Diabetes Agnès Hartemann-Heurtier, Lennart T. Mars, Nadège Bercovici, Sabine Desbois, Christophe Cambouris, Eliane Piaggio, Jacques Zappulla, Abdelhadi Saoudi, and Roland S. Liblau

915-922

Alloantigen-Induced CD25+CD4+ Regulatory T Cells Can Develop In Vivo from CD25-CD4+ Precursors in a Thymus-Independent Process Mahzuz Karim, Cherry I. Kingsley, Andrew R. Bushell, Birgit S. Sawitzki, and Kathryn J. Wood

923-928

TCR Vaccines against a Murine T Cell Lymphoma: A Primary Role for Antibodies of the IgG2c Class in Tumor Protection Stacie L. Lambert, Craig Y. Okada, and Ronald Levy

929-936

Regulation of Autoimmune Diabetes by Complete Freund’s Adjuvant Is Mediated by NK Cells I-Fang Lee, Huilian Qin, Jacqueline Trudeau, Jan Dutz, and Rusung Tan

937-942

Dissociation of NKT Stimulation, Cytokine Induction, and NK 943-953

Activation In Vivo by the Use of Distinct TCR-Binding Ceramides John R. Ortaldo, Howard A. Young, Robin T. Winkler-Pickett, Earl W. Bere, Jr., William J. Murphy, and Robert H. Wiltrout IL-12p70-Dependent Th1 Induction by Human B Cells Requires Combined Activation with CD40 Ligand and CpG DNA Moritz Wagner, Hendrik Poeck, Bernd Jahrsdoerfer, Simon Rothenfusser, Domenik Prell, Barbara Bohle, Evelyn Tuma, Thomas Giese, Joachim W. Ellwart, Stefan Endres, and Gunther Hartmann

954-963

Early Growth Response Gene 3 Regulates Thymocyte Proliferation during the Transition from CD4-CD8- to CD4+CD8+1 Hongkang Xi and Gilbert J. Kersh

964-971

The Cell Surface-Localized Heat Shock Protein 70 Epitope TKD Induces Migration and Cytolytic Activity Selectively in Human NK Cells Robert Gastpar, Catharina Gross, Lydia Rossbacher, Joachim Ellwart, Julia Riegger, and Gabriele Multhoff

972-980

A Switch in Costimulation from CD28 to 4-1BB during Primary versus Secondary CD8 T Cell Response to Influenza In Vivo Edward M. Bertram, Wojciech Dawicki, Bradley Sedgmen, Jonathan L. Bramson, David H. Lynch, and Tania H. Watts

981-988

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species Sergei Kusmartsev, Yulia Nefedova, Daniel Yoder, and Dmitry I. Gabrilovich

989-999

In a Transgenic Model of Spontaneous Autoimmune Diabetes, Expression of a Protective Class II MHC Molecule Results in Thymic Deletion of Diabetogenic CD8+ T Cells David J. Morgan, C. Thomas Nugent, Benjamin J. E. Raveney, and Linda A. Sherman

1000-1008

Liver Dendritic Cells Are Less Immunogenic Than Spleen Dendritic Cells because of Differences in Subtype Composition Venu G. Pillarisetty, Alaap B. Shah, George Miller, Joshua I. Bleier, and Ronald P. DeMatteo

1009-1017

Development of the Dendritic Cell System during Mouse Ontogeny Aleksandar Dakic, Qi-xiang Shao, Angela D’Amico, Meredith O’Keeffe, Wei-feng Chen, Ken Shortman, and Li Wu

1018-1027

IL-10 Induces Regulatory T Cell Apoptosis by Up-Regulation of the Membrane Form of TNF- Luciano E. Marra, Zhu X. Zhang, Betty Joe, Jon Campbell, Gary A. Levy, Josef

1028-1035

Ultraviolet Radiation-Induced Regulatory T Cells Not Only Inhibit the Induction but Can Suppress the Effector Phase of Contact Hypersensitivity Agatha Schwarz, Akira Maeda, Martin K. Wild, Kerstin Kernebeck, Nicole Gross, Yoshinori Aragane, Stefan Beissert, Dietmar Vestweber, and Thomas Schwarz

1036-1043

MOLECULAR AND STRUCTURAL IMMUNOLOGY Allelic Variation at the VHa Locus in Natural Populations of Rabbit (Oryctolagus cuniculus, L.) Pedro J. Esteves, Dennis Lanning, Nuno Ferrand, Katherine L. Knight,

1044-1053

Shi-Kang Zhai, and Wessel van der Loo NF-B and Oct-2 Synergize to Activate the Human 3' Igh hs4 Enhancer in B Cells Manuel A. Sepulveda, Alexander V. Emelyanov, and Barbara K. Birshtein

1054-1064

CD23 Trimers Are Preassociated on the Cell Surface Even in the Absence of Its Ligand, IgE Michelle A. Kilmon, Anne E. Shelburne, Yee Chan-Li, Kevin L. Holmes, and Daniel H. Conrad

1065-1073

Genomic Ly49A Transgenes: Basis of Variegated Ly49A Gene Expression and Identification of a Critical Regulatory Element Dawn M. Tanamachi, Deborah C. Moniot, Dragana Cado, Scot D. Liu, Jennifer K. Hsia, and David H. Raulet

1074-1082

Quantitative Analysis of Prion-Protein Degradation by Constitutive and Immuno-20S Proteasomes Indicates Differences Correlated with Disease Susceptibility Stefan Tenzer, Lars Stoltze, Birgitt Schönfisch, Jörn Dengjel, Margret Müller, Stefan Stevanovic, Hans-Georg Rammensee, and Hansjörg Schild

1083-1091

Polymorphisms in IL-4R Correlate with Airways Hyperreactivity, Eosinophilia, and Ym Protein Expression in Allergic IL-13-/- Mice Dianne C. Webb, Klaus I. Matthaei, Yeping Cai, Andrew N. J. McKenzie, and Paul S. Foster

1092-1098

Wnt Target Genes Identified by DNA Microarrays in Immature CD34+ Thymocytes Regulate Proliferation and Cell Adhesion Frank J. T. Staal, Floor Weerkamp, Miranda R. M. Baert, Caroline M. M. van den Burg, Mascha van Noort, Edwin F. E. de Haas, and Jacques J. M. van Dongen

1099-1108

Enhanced Catalytic Action of HLA-DM on the Exchange of Peptides Lacking Backbone Hydrogen Bonds between their N-Terminal Region and the MHC Class II -Chain Efstratios Stratikos, Don C. Wiley, and Lawrence J. Stern

1109-1117

Role of Commensal Bacteria in Development of Gut-Associated Lymphoid Tissues and Preimmune Antibody Repertoire Ki-Jong Rhee, Periannan Sethupathi, Adam Driks, Dennis K. Lanning, and Katherine L. Knight

1118-1124

HOST DEFENSE The Epidermal Growth Factor-Seven Transmembrane (EGF-TM7) Receptor CD97 Is Required for Neutrophil Migration and Host Defense Jaklien C. Leemans, Anje A. te Velde, Sandrine Florquin, Roelof J. Bennink, Kora de Bruin, René A. W. van Lier, Tom van der Poll, and Jörg Hamann

1125-1131

T Cytotoxic-1 CD8+ T Cells Are Effector Cells against Pneumocystis in Mice Florencia Mc Allister, Chad Steele, Mingquan Zheng, Erana Young, Judd E. Shellito, Luis Marrero, and Jay K. Kolls

1132-1138

IgE Enhances Parasite Clearance and Regulates Mast Cell Responses in Mice Infected with Trichinella spiralis Michael F. Gurish, Paul J. Bryce, Hong Tao, Alison B. Kisselgof, Elizabeth M. Thornton, Hugh R. Miller, Daniel S. Friend, and Hans C.

1139-1145

Oettgen The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization Donald J. Davidson, Andrew J. Currie, Gregor S. D. Reid, Dawn M. E. Bowdish, Kelly L. MacDonald, Rebecca C. Ma, Robert E. W. Hancock, and David P. Speert

1146-1156

The Role of SIGNR1 and the -Glucan Receptor (Dectin-1) in the Nonopsonic Recognition of Yeast by Specific Macrophages Philip R. Taylor, Gordon D. Brown, Jurgen Herre, David L. Williams, Janet A. Willment, and Siamon Gordon

1157-1162

Mice Deficient in LRG-47 Display Increased Susceptibility to Mycobacterial Infection Associated with the Induction of Lymphopenia Carl G. Feng, Carmen M. Collazo-Custodio, Michael Eckhaus, Sara Hieny, Yasmine Belkaid, Karen Elkins, Dragana Jankovic, Gregory A. Taylor, and Alan Sher

1163-1168

Staphylococcus aureus Resists Human Defensins by Production of Staphylokinase, a Novel Bacterial Evasion Mechanism Tao Jin, Maria Bokarewa, Timothy Foster, Jennifer Mitchell, Judy Higgins, and Andrej Tarkowski

1169-1176

Expression of Signaling Lymphocytic Activation Molecule- Associated Protein Interrupts IFN- Production in Human Tuberculosis Virginia Pasquinelli, María F. Quiroga, Gustavo J. Martínez, Liliana Castro Zorrilla, Rosa M. Musella, María M. Bracco, Liliana Belmonte, Alejandro Malbrán, Leonardo Fainboim, Peter A. Sieling, and Verónica E. García

1177-1185

The Dendritic Cell Receptor DC-SIGN Discriminates among Species and Life Cycle Forms of Leishmania María Colmenares, Angel L. Corbí, Salvatore J. Turco, and Luis Rivas

1186-1190

Generation of a Complement-Independent Bactericidal IgM against a Relapsing Fever Borrelia Sean E. Connolly, David G. Thanassi, and Jorge L. Benach

1191-1197

L-Ficolin Specifically Binds to Lipoteichoic Acid, a Cell Wall Constituent of Gram-Positive Bacteria, and Activates the Lectin Pathway of Complement Nicholas J. Lynch, Silke Roscher, Thomas Hartung, Siegfried Morath, Misao Matsushita, Daniela N. Maennel, Mikio Kuraya, Teizo Fujita, and Wilhelm J. Schwaeble

1198-1202

Identification of a Novel FcRIIIa-Associated Molecule That Contains Significant Homology to Porcine Cathelin Susan E. Sweeney and Yoon B. Kim

1203-1212

Different Functional Capacities of Latent and Lytic Antigen-Specific CD8 T Cells in Murine Gammaherpesvirus Infection Joshua J. Obar, Sarah G. Crist, David C. Gondek, and Edward J. Usherwood

1213-1219

INFLAMMATION Carbon Monoxide Inhibits T Lymphocyte Proliferation via Caspase-Dependent Pathway Ruiping Song, Raja S. Mahidhara, Zhihong Zhou, Rosemary A. Hoffman, Dai-Wu Seol, Richard A. Flavell, Timothy R. Billiar, Leo E. Otterbein, and Augustine M. K. Choi

1220-1226

Prostaglandin E2 Induces Degranulation-Independent Production of Vascular Endothelial Growth Factor by Human Mast Cells Raja M. Abdel-Majid and Jean S. Marshall

1227-1236

CXCR2-/- Mice Show Enhanced Susceptibility to Herpetic Stromal Keratitis: A Role for IL-6-Induced Neovascularization Kaustuv Banerjee, Partha S. Biswas, Bumseok Kim, Sujin Lee, and Barry T. Rouse

1237-1245

Semaphorin CD100 from Activated T Lymphocytes Induces Process Extension Collapse in Oligodendrocytes and Death of Immature Neural Cells Pascale Giraudon, Peggy Vincent, Carine Vuaillat, Olivier Verlaeten, Luis Cartier, Anne Marie-Cardine, Mireille Mutin, Armand Bensussan, Marie-Françoise Belin, and Laurence Boumsell

1246-1255

Chemokine Secretion of Rheumatoid Arthritis Synovial Fibroblasts Stimulated by Toll-Like Receptor 2 Ligands Matthias Pierer, Janine Rethage, Reinhart Seibl, Roger Lauener, Fabia Brentano, Ulf Wagner, Holm Hantzschel, Beat A. Michel, Renate E. Gay, Steffen Gay, and Diego Kyburz

1256-1265

Bone Marrow-Derived Progenitor Cells Are Important for Lung Repair after Lipopolysaccharide-Induced Lung Injury Mitsuhiro Yamada, Hiroshi Kubo, Seiichi Kobayashi, Kota Ishizawa, Muneo Numasaki, Shinsaku Ueda, Takashi Suzuki, and Hidetada Sasaki

1266-1272

CLINICAL IMMUNOLOGY Potential Targets of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor for Multiple Sclerosis Therapy Narender Nath, Shailendra Giri, Ratna Prasad, Avtar K. Singh, and Inderjit Singh

1273-1286

Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus Insoo Kang, Timothy Quan, Helena Nolasco, Sung-Hwan Park, Myung Sun Hong, Jill Crouch, Eric G. Pamer, John Greg Howe, and Joe Craft

1287-1294

Periportal Fibrosis in Human Schistosoma mansoni Infection Is Associated with Low IL-10, Low IFN-, High TNF-, or Low RANTES, Depending on Age and Gender Mark Booth, Joseph K. Mwatha, Sarah Joseph, Frances M. Jones, Hilda Kadzo, Edmund Ireri, Frances Kazibwe, Jovanice Kemijumbi, Curtis Kariuki, Gachuhi Kimani, John H. Ouma, Narcis B. Kabatereine, Birgitte J. Vennervald, and David W. Dunne

1295-1303

Functional Analysis of Tumor-Specific Th Cell Responses Detected in Melanoma Patients after Dendritic Cell-Based Immunotherapy Erwin S. Schultz, Beatrice Schuler-Thurner, Vincent Stroobant, Lars Jenne, Thomas G. Berger, Kris Thielemanns, Pierre van der Bruggen, and Gerold Schuler

1304-1310

CORRECTIONS Interdependence of N Nucleotide Addition and Recombination Site Choice in V(D)J Rearrangement Thomas B. Kepler, Michelle Borrero, Beth Rugerio, Suzanne K. McCray, and Stephen H. Clarke

1311

IL-10 Mediates Suppression of the CD8 T Cell IFN-. Response to a Novel Viral Epitope in a Primed Host

1311

Xiao Song Liu, Yan Xu, Lani Hardy, Vithagna Khammanivong, Weiming Zhao, Germain J. P. Fernando, Graham R. Leggatt, and Ian H. Frazer

VOL.172, NO. 3, FEBRUARY 1; 2004 IN THIS ISSUE 1331-1332 BRIEF REVIEWS NK Cell Compartments and Their Activation by Dendritic Cells Guido Ferlazzo and Christian Münz

1333-1339

CUTTING EDGE Cutting Edge: Distinct TCR- and CD28-Derived Signals Regulate CD95L, Bcl-xL, and the Survival of Primary T Cells Andreas Kerstan and Thomas Hünig

1341-1345

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION Induction of Tumor Regression by Administration of B7-Ig Fusion Proteins: Mediation by Type 2 CD8+ T Cells and Dependence on IL-4 Production Nobuya Yamaguchi, Shin-ichiro Hiraoka, Takao Mukai, Noritami Takeuchi, Xu-Yu Zhou, Shiro Ono, Mikihiko Kogo, Kyriaki Dunussi-Joannopoulos, Vincent Ling, Stanley Wolf, and Hiromi Fujiwara

1347-1354

Mechanistic Insights into Impaired Dendritic Cell Function by Rapamycin: Inhibition of Jak2/Stat4 Signaling Pathway Po-Hui Chiang, Lianfu Wang, C. Andrew Bonham, Xiaoyan Liang, John J. Fung, Lina Lu, and Shiguang Qian

1355-1363

Tolerance Induction by Intrathymic Expression of P0 Lucian Visan, Ioana A. Visan, Andreas Weishaupt, Harald H. Hofstetter, Klaus V. Toyka, Thomas Hünig, and Ralf Gold

1364-1370

Cellular Maturation Defects in Bruton’s Tyrosine Kinase-Deficient Immature B Cells Are Amplified by Premature B Cell Receptor Expression and Reduced by Receptor Editing Sabine Middendorp and Rudolf W. Hendriks

1371-1379

Tc1 and Tc2 Effector Cell Therapy Elicit Long-Term Tumor Immunity by Contrasting Mechanisms That Result in Complementary Endogenous Type 1 Antitumor Responses Mark J. Dobrzanski, Joyce B. Reome, Joseph A. Hollenbaugh, and Richard W. Dutton

1380-1390

IL-11 Protects Human Microvascular Endothelium from Alloinjury In Vivo by Induction of Survivin Expression Nancy C. Kirkiles-Smith, Keyvan Mahboubi, Janet Plescia, Jennifer M. McNiff, James Karras, Jeffrey S. Schechner, Dario C. Altieri, and Jordan S. Pober

1391-1396

Mature Human Thymocytes Migrate on Laminin-5 with Activation of Metalloproteinase-14 and Cleavage of CD44 Mylène Vivinus-Nebot, Patricia Rousselle, Jean-Philippe Breittmayer, Claire Cenciarini, Sonia Berrih-Aknin, Suzanne Spong, Pasi Nokelainen, Françoise Cottrez, M. Peter Marinkovich, and Alain Bernard

1397-1406

CCL17 and IL-10 as Effectors That Enable Alternatively Activated Macrophages to Inhibit the Generation of Classically Activated Macrophages

1407-1413

Tatsushi Katakura, Masaru Miyazaki, Makiko Kobayashi, David N. Herndon, and Fujio Suzuki Independent Control of Ly49g Alleles: Implications for NK Cell Repertoire Selection and Tumor Cell Killing Andrew P. Makrigiannis, Etienne Rousselle, and Stephen K. Anderson

1414-1425

Estrogen Preferentially Promotes the Differentiation of CD11c+ CD11bintermediate Dendritic Cells from Bone Marrow Precursors Vladislava Paharkova-Vatchkova, Ruben Maldonado, and Susan Kovats

1426-1436

Lck Is Required for Activation-Induced T Cell Death after TCR Ligation with Partial Agonists Xue-Zhong Yu, Steven D. Levin, Joaquin Madrenas, and Claudio Anasetti

1437-1443

Chimeric Donor Cells Play an Active Role in Both Induction and Maintenance Phases of Transplantation Tolerance Induced by Mixed Chimerism Akira Kanamoto and Takashi Maki

1444-1448

Importance of IL-10 for CTLA-4-Mediated Inhibition of Tumor-Eradicating Immunity Vladimir M. Jovasevic, Leonid Gorelik, Jeffrey A. Bluestone, and Margalit B. Mokyr

1449-1454

The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic Guido Ferlazzo, Dolca Thomas, Shao-Lee Lin, Kiera Goodman, Barbara Morandi, William A. Muller, Alessandro Moretta, and Christian Münz

1455-1462

Production of Donor T Cells Is Critical for Induction of Donor-Specific Tolerance and Maintenance of Chimerism Hong Xu, Paula M. Chilton, Yiming Huang, Carrie L. Schanie, and Suzanne T. Ildstad

1463-1471

-Associated Protein of 70 kDa (ZAP-70), but Not Syk, Tyrosine Kinase Can Mediate Apoptosis of T Cells through the Fas/Fas Ligand, Caspase-8 and Caspase-3 Pathways Lingwen Zhong, Chun-Hua Wu, Wen-Hui Lee, and Chih-Pin Liu

1472-1482

Zwitterionic Polysaccharides Stimulate T Cells with No Preferential V Usage and Promote Anergy, Resulting in Protection against Experimental Abscess Formation Francesca Stingele, Blaise Corthésy, Nicole Kusy, Steven A. Porcelli, Dennis L. Kasper, and Arthur O. Tzianabos

1483-1490

Effect of Chronic Viral Infection on Epitope Selection, Cytokine Production, and Surface Phenotype of CD8 T Cells and the Role of IFN- Receptor in Immune Regulation Kavita Tewari, Jonah Sacha, Xiaoyan Gao, and M. Suresh

1491-1500

CpG-DNA Aided Cross-Priming by Cross-Presenting B Cells Antje Heit, Katharina M. Huster, Frank Schmitz, Matthias Schiemann, Dirk H. Busch, and Hermann Wagner

1501-1507

Tumor-Infiltrating Lymphocyte Secretion of IL-6 Antagonizes Tumor-Derived TGF-1 and Restores the Lymphokine-Activated Killing Activity Ya-Wen Hsiao, Kuang-Wen Liao, Shao-Wen Hung, and Rea-Min Chu

1508-1514

Expression of Dual TCR on DO11.10 T Cells Allows for Ovalbumin- 1515-1523

Induced Oral Tolerance to Prevent T Cell-Mediated Colitis Directed against Unrelated Enteric Bacterial Antigens Pengfei Zhou, Rajka Borojevic, Cathy Streutker, Denis Snider, Hong Liang, and Kenneth Croitoru Early Adenoviral Gene Expression Mediates Immunosuppression by Transduced Dendritic Cell (DC): Implications for Immunotherapy Using Genetically Modified DC Andrea Tuettenberg, Helmut Jonuleit, Thomas Tüting, Jürgen Brück, Volker Biermann, Stefan Kochanek, Jürgen Knop, and Alexander H. Enk

1524-1530

CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF- Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome Song Guo Zheng, Ju Hua Wang, Michael N. Koss, Francisco Quismorio, Jr., J. Dixon Gray, and David Allen Horwitz

1531-1539

IL-21 Induces Tumor Rejection by Specific CTL and IFN--Dependent CXC Chemokines in Syngeneic Mice Emma Di Carlo, Alberto Comes, Anna Maria Orengo, Ombretta Rosso, Raffaella Meazza, Piero Musiani, Mario P. Colombo, and Silvano Ferrini

1540-1547

Deceptive Multilineage Reconstitution Analysis of Mice Transplanted with Hemopoietic Stem Cells, and Implications for Assessment of Stem Cell Numbers and Lineage Potentials David Bryder, Yutaka Sasaki, Ole Johan Borge, and Sten-Eirik W. Jacobsen

1548-1552

Autoreactive B Cells in Lupus-Prone New Zealand Black Mice Exhibit Aberrant Survival and Proliferation in the Presence of Self-Antigen In Vivo Nan-Hua Chang, Ralph MacLeod, and Joan E. Wither

1553-1560

Phosphatidylinositol 3-Kinase Is a Determinant of Responsiveness to B Cell Antigen Receptor-Mediated Epstein-Barr Virus Activation Dai Iwakiri and Kenzo Takada

1561-1566

Intraocular Tumor Antigen Drains Specifically to Submandibular Lymph Nodes, Resulting in an Abortive Cytotoxic T Cell Reaction Zita F. H. M. Boonman, Geertje J. D. van Mierlo, Marieke F. Fransen, Kees L. M. C. Franken, Rienk Offringa, Cornelis J. M. Melief, Martine J. Jager, and René E. M. Toes

1567-1574

E-Selectin, Thymus- and Activation-Regulated Chemokine/CCL17, and Intercellular Adhesion Molecule-1 Are Constitutively Coexpressed in Dermal Microvessels: A Foundation for a Cutaneous Immunosurveillance System Benjamin F. Chong, Jo-Ellen Murphy, Thomas S. Kupper, and Robert C. Fuhlbrigge

1575-1581

Intravenous Injection of a Lentiviral Vector Encoding NY-ESO-1 Induces an Effective CTL Response Michael J. Palmowski, Luciene Lopes, Yasuhiro Ikeda, Mariolina Salio, Vincenzo Cerundolo, and Mary K. Collins

1582-1587

IFN- Promotes Fas Ligand- and Perforin-Mediated Liver Cell Destruction by Cytotoxic CD8 T Cells Evelyn Roth and Hanspeter Pircher

1588-1594

Escherichia coli Expressing Recombinant Antigen and Listeriolysin O Stimulate Class I-Restricted CD8+ T Cells following Uptake by Human APC Paul Q. Hu, Renee J. Tuma-Warrino, Marianne A. Bryan, Kathleen G. Mitchell, Darren E. Higgins, Simon C. Watkins, and Russell D. Salter

1595-1601

Characterization of Defective CD4-CD8- T Cells in Murine Tumors Generated Independent of Antigen Specificity Robert M. Prins, Francesca Incardona, Regan Lau, Paul Lee, Sarah Claus, Wenxuan Zhang, Keith L. Black, and Christopher J. Wheeler

1602-1611

Regulation of c-Jun N-Terminal Kinase by MEKK-2 and Mitogen-Activated Protein Kinase Kinase Kinases in Rheumatoid Arthritis Deepa R. Hammaker, David L. Boyle, Martine Chabaud-Riou, and Gary S. Firestein

1612-1618

The Role of TNF-Related Activation-Induced Cytokine–Receptor Activating NF-B Interaction in Acute Allograft Rejection and CD40L-Independent Chronic Allograft Rejection Carole Guillonneau, Cédric Louvet, Karine Renaudin, Jean-Marie Heslan, Michèle Heslan, Laurent Tesson, Caroline Vignes, Cécile Guillot, Yongwon Choi, Lawrence A. Turka, Maria-Cristina Cuturi, Ignacio Anegon, and Régis Josien

1619-1629

Blockade of Lymphotoxin Signaling Inhibits the Clinical Expression of Murine Graft-versus-Host Skin Disease Qiang Wu, Yang-Xin Fu, and Richard D. Sontheimer

1630-1636

Ontogeny of T Cells in Humans Stephen C. De Rosa, James P. Andrus, Stephen P. Perfetto, John J. Mantovani, Leonard A. Herzenberg, Leonore A. Herzenberg, and Mario Roederer

1637-1645

IFN- Induced Adenosine Production on the Endothelium: A Mechanism Mediated by CD73 (Ecto-5'-Nucleotidase) Up-Regulation Jussi Niemelä, Tiina Henttinen, Gennady G. Yegutkin, Laura Airas, Anna-Maija Kujari, Pertti Rajala, and Sirpa Jalkanen

1646-1653

Nuclear Pro-IL-16 Regulation of T Cell Proliferation: p27KIP1-Dependent G0/G1 Arrest Mediated by Inhibition of Skp2 Transcription David M. Center, William W. Cruikshank, and Yujun Zhang

1654-1660

MOLECULAR AND STRUCTURAL IMMUNOLOGY The Nonclassical MHC Class I Molecule Qa-1 Forms Unstable Peptide Complexes Taku Kambayashi, Jennifer R. Kraft-Leavy, Joseph G. Dauner, Barbara A. Sullivan, Oskar Laur, and Peter E. Jensen

1661-1669

The C4A and C4B Isotypic Forms of Human Complement Fragment C4b Have the Same Intrinsic Affinity for Complement Receptor 1 (CR1/CD35) Liliana Clemenza and David E. Isenman

1670-1680

Hypoxia Selectively Inhibits Monocyte Chemoattractant Protein-1 Production by Macrophages Maria Carla Bosco, Maura Puppo, Sandra Pastorino, Zenghui Mi, Giovanni Melillo, Stefano Massazza, Annamaria Rapisarda, and Luigi Varesio

1681-1690

Critical Role of OX40 in CD28 and CD154-Independent Rejection Gülçin Demirci, Farhana Amanullah, Reshma Kewalaramani, Hideo

1691-1698

Yagita, Terry B. Strom, Mohamed H. Sayegh, and Xian Chang Li HOST DEFENSE IFN- Sensitizes Human Umbilical Vein Endothelial Cells to Apoptosis Induced by Double-Stranded RNA William J. Kaiser, Jonathan L. Kaufman, and Margaret K. Offermann

1699-1710

Impaired Production of Proinflammatory Cytokines and Host Resistance to Acute Infection with Trypanosoma cruzi in Mice Lacking Functional Myeloid Differentiation Factor 88 Marco A. Campos, Meire Closel, Eneida P. Valente, Jarbas E. Cardoso, Shizuo Akira, Jacqueline I. Alvarez-Leite, Catherine Ropert, and Ricardo T. Gazzinelli

1711-1718

HLA Class II Polymorphisms Determine Responses to Bacterial Superantigens Martin Llewelyn, Shiranee Sriskandan, Mark Peakman, David R. Ambrozak, Daniel C. Douek, William W. Kwok, Jonathan Cohen, and Daniel M. Altmann

1719-1726

Dendritic Cells Pulsed with Live and Dead Legionella pneumophila Elicit Distinct Immune Responses Toshiaki Kikuchi, Takao Kobayashi, Kazunori Gomi, Takuji Suzuki, Yutaka Tokue, Akira Watanabe, and Toshihiro Nukiwa

1727-1734

Human T Cell Lymphotropic Virus Type I (HTLV-I)-Specific CD4+ T Cells: Immunodominance Hierarchy and Preferential Infection with HTLV-I Peter K. C. Goon, Tadahiko Igakura, Emmanuel Hanon, Angelina J. Mosley, Anna Barfield, Amanda L. Barnard, Lambrini Kaftantzi, Yuetsu Tanaka, Graham P. Taylor, Jonathan N. Weber, and Charles R. M. Bangham

1735-1743

Pervasive Influence of Hepatitis C Virus on the Phenotype of Antiviral CD8+ T Cells Michaela Lucas, Ana L. Vargas-Cuero, Georg M. Lauer, Eleanor Barnes, Christian B. Willberg, Nasser Semmo, Bruce D. Walker, Rodney Phillips, and Paul Klenerman

1744-1753

Distinct Modulatory Effects of LPS and CpG on IL-18-Dependent IFN- Synthesis Meetha P. Gould, Jennifer A. Greene, Vijay Bhoj, Jennifer L. DeVecchio, and Frederick P. Heinzel

1754-1762

Selective Killing of Vaccinia Virus by LL-37: Implications for Eczema Vaccinatum Michael D. Howell, James F. Jones, Kevin O. Kisich, Joanne E. Streib, Richard L. Gallo, and Donald Y. M. Leung

1763-1767

Chlamydia pneumoniae Multiply in Neutrophil Granulocytes and Delay Their Spontaneous Apoptosis Ger van Zandbergen, Jens Gieffers, Henning Kothe, Jan Rupp, Annalena Bollinger, Eresso Aga, Matthias Klinger, Helmut Brade, Klaus Dalhoff, Matthias Maass, Werner Solbach, and Tamás Laskay

1768-1776

Nonmethylated CG Motifs Packaged into Virus-Like Particles Induce Protective Cytotoxic T Cell Responses in the Absence of Systemic Side Effects Tazio Storni, Christiane Ruedl, Katrin Schwarz, Reto A. Schwendener, Wolfgang A. Renner, and Martin F. Bachmann

1777-1785

Overproduction of TNF- by CD8+ Type 1 Cells and Down-Regulation of IFN- Production by CD4+ Th1 Cells Contribute to Toxic Shock-Like Syndrome in an Animal Model of Fatal Monocytotropic Ehrlichiosis Nahed Ismail, Lynn Soong, Jere W. McBride, Gustavo Valbuena, Juan P. Olano, Hui-Min Feng, and David H. Walker

1786-1800

p47phox Deficiency Impairs NF-B Activation and Host Defense in Pseudomonas Pneumonia Ruxana T. Sadikot, Heng Zeng, Fiona E. Yull, Bo Li, Dong-sheng Cheng, Douglas S. Kernodle, E. Duco Jansen, Christopher H. Contag, Brahm H. Segal, Steven M. Holland, Timothy S. Blackwell, and John W. Christman

1801-1808

INFLAMMATION Leptin Indirectly Activates Human Neutrophils via Induction of TNF- Hamid Zarkesh-Esfahani, Alan G. Pockley, Zida Wu, Paul G. Hellewell, Anthony P. Weetman, and Richard J. M. Ross

1809-1814

Transcript Signatures in Experimental Asthma: Identification of STAT6-Dependent and -Independent Pathways Nives Zimmermann, Anil Mishra, Nina E. King, Patricia C. Fulkerson, Matthew P. Doepker, Nikolaos M. Nikolaidis, Laura E. Kindinger, Elizabeth A. Moulton, Bruce J. Aronow, and Marc E. Rothenberg

1815-1824

Macrophage-Stimulating Protein, the Ligand for the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase, Inhibits IL-12 Production by Primary Peritoneal Macrophages Stimulated with IFN- and Lipopolysaccharide Amy C. Morrison, Caleph B. Wilson, Manujendra Ray, and Pamela H. Correll

1825-1832

Cysteinyl Leukotrienes Regulate Dendritic Cell Functions in a Murine Model of Asthma Ikuko Machida, Hiroto Matsuse, Yuki Kondo, Tetsuya Kawano, Sachiko Saeki, Shinya Tomari, Yasushi Obase, Chizu Fukushima, and Shigeru Kohno

1833-1838

Kinin B1 Receptor Up-Regulation after Lipopolysaccharide Administration: Role of Proinflammatory Cytokines and Neutrophil Influx Giselle F. Passos, Elizabeth S. Fernandes, Maria M. Campos, José G. V. C. Araújo, Jorge L. Pesquero, Glória E. P. Souza, Maria C. W. Avellar, Mauro M. Teixeira, and João B. Calixto

1839-1847

The Essential Involvement of Cross-Talk between IFN- and TGF- in the Skin Wound-Healing Process Yuko Ishida, Toshikazu Kondo, Tatsunori Takayasu, Yoichiro Iwakura, and Naofumi Mukaida

1848-1855

A Molecular Defect in Intracellular Lipid Signaling in Human Neutrophils in Localized Aggressive Periodontal Tissue Damage Karsten Gronert, Alpdogan Kantarci, Bruce D. Levy, Clary B. Clish, Sabine Odparlik, Hatice Hasturk, John A. Badwey, Sean P. Colgan, Thomas E. Van Dyke, and Charles N. Serhan

1856-1861

Expression of CD154 (CD40 Ligand) by Human Lung Fibroblasts: Differential Regulation by IFN- and IL-13, and Implications for Fibrosis Julia Kaufman, Patricia J. Sime, and Richard P. Phipps

1862-1871

The C10/CCL6 Chemokine and CCR1 Play Critical Roles in the 1872-1881

Pathogenesis of IL-13-Induced Inflammation and Remodeling Bing Ma, Zhou Zhu, Robert J. Homer, Craig Gerard, Robert Strieter, and Jack A. Elias Immune Complexes Bind Preferentially to FcRIIA (CD32) on Apoptotic Neutrophils, Leading to Augmented Phagocytosis by Macrophages and Release of Proinflammatory Cytokines Simon P. Hart, Karen M. Alexander, and Ian Dransfield

882-1887

Induction of C Chemokine XCL1 (Lymphotactin/Single C Motif-1/Activation-Induced, T Cell-Derived and Chemokine-Related Cytokine) Expression by HIV-1 Tat Protein Byung Oh Kim, Ying Liu, Betty Y. Zhou, and Johnny J. He

1888-1895

Chemotaxis and Calcium Responses of Phagocytes to Formyl Peptide Receptor Ligands Is Differentially Regulated by Cyclic ADP Ribose Santiago Partida-Sánchez, Pablo Iribarren, Miguel E. Moreno-García, Ji-Liang Gao, Philip M. Murphy, Norman Oppenheimer, Ji Ming Wang, and Frances E. Lund

1896-1906

TNF--Induced Apoptosis of Macrophages Following Inhibition of NF-B: A Central Role for Disruption of Mitochondria Hongtao Liu, Yingyu Ma, Lisa J. Pagliari, Harris Perlman, Chenfei Yu, Anning Lin, and Richard M. Pope

1907-1915

CLINICAL IMMUNOLOGY Lymphoid Hyperplasia Resulting in Immune Dysregulation Is Caused by Porcine Reproductive and Respiratory Syndrome Virus Infection in Neonatal Pigs Caitlin D. Lemke, Joseph S. Haynes, Rodger Spaete, Deb Adolphson, Ann Vorwald, Kelly Lager, and John E. Butler

1916-1925

Metal-Protein Complex-Mediated Transport and Delivery of Ni2+ to TCR/MHC Contact Sites in Nickel-Specific Human T Cell Activation Hermann-Josef Thierse, Corinne Moulon, Yvonne Allespach, Bastian Zimmermann, Andrea Doetze, Stephan Kuppig, Doris Wild, Friedrich Herberg, and Hans Ulrich Weltzien

1926-1934

Nucleotide Sequencing of Psoriatic Arthritis Tissue before and during Methotrexate Administration Reveals a Complex Inflammatory T Cell Infiltrate with Very Few Clones Exhibiting Features That Suggest They Drive the Inflammatory Process by Recognizing Autoantigens Shane A. Curran, Oliver M. FitzGerald, Patrick J. Costello, Jeanette M. Selby, David J. Kane, Barry Bresnihan, and Robert Winchester

1935-1944

Ets-1 Regulates TNF--Induced Matrix Metalloproteinase-9 and Tenascin Expression in Primary Bronchial Fibroblasts Yutaka Nakamura, Stéphane Esnault, Takashi Maeda, Elizabeth A. B. Kelly, James S. Malter, and Nizar N. Jarjour

1945-1952

Mycobacterium tuberculosis Recall Antigens Suppress HIV-1 Replication in Anergic Donor Cells via CD8+ T Cell Expansion and Increased IL-10 Levels Shahin Ranjbar, Nary Ly, Sok Thim, Jean-Marc Reynes, and Anne E. Goldfeld

1953-1959

Molecular Analysis of TCR Clonotypes in LGL: A Clonal Model for Polyclonal Responses Christine L. O’Keefe, Magdalena Plasilova, Marcin Wlodarski, Antonio M. Risitano, Alexander R. Rodriguez, Evan Howe, Neal S. Young, Eric

1960-1969

Hsi, and Jaroslaw P. Maciejewski VOL.172, NO. 4, FEBRUARY 15; 2004

IN THIS ISSUE 1989-1990CUTTING EDGE Cutting Edge: In Vitro-Generated Tolerogenic APC Induce CD8+ T Regulatory Cells That Can Suppress Ongoing Experimental Autoimmune Encephalomyelitis Douglas E. Faunce, Ania Terajewicz, and Joan Stein-Streilein

1991-1995

Cutting Edge: Conventional CD8+ Dendritic Cells Are Generally Involved in Priming CTL Immunity to Viruses Gabrielle T. Belz, Christopher M. Smith, Daniel Eichner, Ken Shortman, Guna Karupiah, Francis R. Carbone, and William R. Heath

1996-2000

Cutting Edge: Toll-Like Receptor Signaling in Macrophages Induces Ligands for the NKG2D Receptor Jessica A. Hamerman, Kouetsu Ogasawara, and Lewis L. Lanier

2001-2005

Cutting Edge: IL-26 Signals through a Novel Receptor Complex Composed of IL-20 Receptor 1 and IL-10 Receptor 2 Faruk Sheikh, Vitaliy V. Baurin, Anita Lewis-Antes, Nital K. Shah, Sergey V. Smirnov, Shubha Anantha, Harold Dickensheets, Laure Dumoutier, Jean-Christophe Renauld, Alexander Zdanov, Raymond P. Donnelly, and Sergei V. Kotenko

2006-2010

Cutting Edge: T Cells Trigger CD40-Dependent Platelet Activation and Granular RANTES Release: A Novel Pathway for Immune Response Amplification Silvio Danese, Carol de la Motte, Brenda M. Rivera Reyes, Miquel Sans, Alan D. Levine, and Claudio Fiocchi

2011-2015

Cutting Edge: Dendritic Cells Copulsed with Microbial and Helminth Antigens Undergo Modified Maturation, Segregate the Antigens to Distinct Intracellular Compartments, and Concurrently Induce Microbe-Specific Th1 and Helminth-Specific Th2 Responses Laura Cervi, Andrew S. MacDonald, Colleen Kane, Florence Dzierszinski, and Edward J. Pearce

2016-2020

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION Visualizing the Site and Dynamics of IgG Salvage by the MHC Class I-Related Receptor, FcRn Raimund J. Ober, Cruz Martinez, Carlos Vaccaro, Jinchun Zhou, and E. Sally Ward

2021-2029

Visualization of Antigen Presentation by Actin-Mediated Targeting of Glycolipid-Enriched Membrane Domains to the Immune Synapse of B Cell APCs Claire Gordy, Sudha Mishra, and William Rodgers

2030-2038

Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages Akiko Shiratsuchi, Ikuko Watanabe, Osamu Takeuchi, Shizuo Akira, and Yoshinobu Nakanishi

2039-2047

IL-21 Induces the Functional Maturation of Murine NK Cells Jason Brady, Yoshihiro Hayakawa, Mark J. Smyth, and Stephen L. Nutt

2048-2058

IL-4 Induces Differentiation and Expansion of Th2 Cytokine-Producing Eosinophils

2059-2066

Luqiu Chen, Kristy A. Grabowski, Jun-ping Xin, John Coleman, Zan Huang, Baltazar Espiritu, Serhan Alkan, H. Bill Xie, Yuechun Zhu, Fletcher A. White, John Clancy, Jr, and Hua Huang NF-B-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner Fumiko Kajiura, Shijie Sun, Takashi Nomura, Keisuke Izumi, Tomoo Ueno, Yoshimi Bando, Noriyuki Kuroda, Hongwei Han, Yi Li, Akemi Matsushima, Yousuke Takahama, Shimon Sakaguchi, Tasuku Mitani, and Mitsuru Matsumoto

2067-2075

Mechanisms Governing B Cell Developmental Defects in Invariant Chain-Deficient Mice Kamel Benlagha, Se-Ho Park, Rodolphe Guinamard, Claire Forestier, Lars Karlsson, Cheong-Hee Chang, and Albert Bendelac

2076-2083

B Cell Receptor-Mediated Apoptosis of Human Lymphocytes Is Associated with a New Regulatory Pathway of Bim Isoform Expression Shahul Mouhamad, Laurence Besnault, Marie Thérèse Auffredou, Corinne Leprince, Marie Françoise Bourgeade, Gérald Leca, and Aimé Vazquez

2084-2091

Transgenic Expression of a Human Polyreactive Ig Expressed in Chronic Lymphocytic Leukemia Generates Memory-Type B Cells That Respond to Nonspecific Immune Activation George F. Widhopf, II, Diana C. Brinson, Thomas J. Kipps, and Helen Tighe

2092-2099

Severely Impaired B Lymphocyte Proliferation, Survival, and Induction of the c-Myc:Cullin 1 Ubiquitin Ligase Pathway Resulting from CD22 Deficiency on the C57BL/6 Genetic Background Jonathan C. Poe, Karen M. Haas, Junji Uchida, Youngkyun Lee, Manabu Fujimoto, and Thomas F. Tedder

2100-2110

Distinct Expression Profiles of the Peripheral Cannabinoid Receptor in Lymphoid Tissues Depending on Receptor Activation Status Nazik Rayman, King H. Lam, Jon D. Laman, Peter J. Simons, Bob Löwenberg, Pieter Sonneveld, and Ruud Delwel

2111-2117

Complete Loss of Fas Ligand Gene Causes Massive Lymphoproliferation and Early Death, Indicating a Residual Activity of gld Allele Saoussen Karray, Chantal Kress, Sylvain Cuvellier, Catherine Hue-Beauvais, Diane Damotte, Charles Babinet, and Matthieu Lévi-Strauss

2118-2125

Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells Fabrice André, Nathalie Chaput, Nöel E. C. Schartz, Caroline Flament, Nathalie Aubert, Jacky Bernard, François Lemonnier, Graça Raposo, Bernard Escudier, Di-Hwei Hsu, Thomas Tursz, Sebastian Amigorena, Eric Angevin, and Laurence Zitvogel

2126-2136

Exosomes as Potent Cell-Free Peptide-Based Vaccine. II. Exosomes in CpG Adjuvants Efficiently Prime Naive Tc1 Lymphocytes Leading to Tumor Rejection Nathalie Chaput, Nöel E. C. Schartz, Fabrice André, Julien Taïeb, Sophie Novault, Pierre Bonnaventure, Nathalie Aubert, Jacky Bernard, François Lemonnier, Miriam Merad, Gosse Adema, Malcolm Adams,

2137-2146

Maria Ferrantini, Antoine F. Carpentier, Bernard Escudier, Thomas Tursz, Eric Angevin, and Laurence Zitvogel Novel Regulatory Mechanisms of CD40-Induced Prostanoid Synthesis by IL-4 and IL-10 in Human Monocytes Yasushi Inoue, Takeshi Otsuka, Hiroaki Niiro, Shuji Nagano, Yojirou Arinobu, Eiichi Ogami, Mitsuteru Akahoshi, Katsuhisa Miyake, Ichiro Ninomiya, Sakiko Shimizu, Hitoshi Nakashima, and Mine Harada

2147-2154

Reduced Ig Class Switch in Aged Mice Correlates with Decreased E47 and Activation-Induced Cytidine Deaminase Daniela Frasca, Elaine Van der Put, Richard L. Riley, and Bonnie B. Blomberg

2155-2162

Dependency of Direct Pathway CD4+ T Cells on CD40-CD154 Costimulation Is Determined by Nature and Microenvironment of Primary Contact with Alloantigen Andre van Maurik, Barbara Fazekas de St. Groth, Kathryn J. Wood, and Nick D. Jones

2163-2170

Disparate In Vitro and In Vivo Requirements for IL-2 During Antigen-Independent CD8 T Cell Expansion Phillip Wong and Eric G. Pamer

2171-2176

A Novel Role for an Insect Apolipoprotein (Apolipophorin III) in -1,3-Glucan Pattern Recognition and Cellular Encapsulation Reactions Miranda M. A. Whitten, Ian F. Tew, Bok L. Lee, and Norman A. Ratcliffe

2177-2185

Extremely Rapid and Intense Induction of Apoptosis in Human Eosinophils by Anti-CD30 Antibody Treatment In Vitro Kenji Matsumoto, Maki Terakawa, Kenju Miura, Shuhei Fukuda, Toshiharu Nakajima, and Hirohisa Saito

2186-2193

Resistance of Short Term Activated T Cells to CD95-Mediated Apoptosis Correlates with De Novo Protein Synthesis of c-FLIPshort Ingo Schmitz, Heiko Weyd, Andreas Krueger, Sven Baumann, Stefanie C. Fas, Peter H. Krammer, and Sabine Kirchhoff

2194-2200

IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals Kathleen F. Nolan, Victoria Strong, Dulce Soler, Paul J. Fairchild, Stephen P. Cobbold, Ruth Croxton, Jose-Angel Gonzalo, Ana Rubio, Meghan Wells, and Herman Waldmann

2201-2209

The Cytoplasmic Domain of Ig Is Necessary and Sufficient to Support Efficient Early B Cell Development Kelly A. Pike, Sandra Iacampo, Jennifer E. Friedmann, and Michael J. H. Ratcliffe

2210-2218

HIV-Infected Langerhans Cells Preferentially Transmit Virus to Proliferating Autologous CD4+ Memory T Cells Located within Langerhans Cell-T Cell Clusters Makoto Sugaya, Karin Loré, Richard A. Koup, Daniel C. Douek, and Andrew Blauvelt

2219-2224

WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27 Stefan Pflanz, Linda Hibbert, Jeanine Mattson, Rency Rosales, Elena Vaisberg, J. Fernando Bazan, Joseph H. Phillips, Terrill K.

2225-2231

McClanahan, Rene de Waal Malefyt, and Robert A. Kastelein Identification of New Antigenic Peptide Presented by HLA-Cw7 and Encoded by Several MAGE Genes Using Dendritic Cells Transduced with Lentiviruses Karine Breckpot, Carlo Heirman, Catherine De Greef, Pierre van der Bruggen, and Kris Thielemans

2232-2237

Antigen Nonspecific Suppression of T Cell Responses by Activated Stimulation-Refractory CD4+ T Cells Christine T. Duthoit, Phuong Nguyen, and Terrence L. Geiger

2238-2246

The Impact of Thymic Antigen Diversity on the Size of the Selected T Cell Repertoire Jose Faro, Santiago Velasco, África González-Fernández, and Antonio Bandeira

2247-2255

Human Cytomegalovirus Proteins pp65 and Immediate Early Protein 1 Are Common Targets for CD8+ T Cell Responses in Children with Congenital or Postnatal Human Cytomegalovirus Infection Laura Gibson, Giampiero Piccinini, Daniele Lilleri, Maria Grazia Revello, Zhongde Wang, Susan Markel, Don J. Diamond, and Katherine Luzuriaga

2256-2264

NF-B Controls Cell Fate Specification, Survival, and Molecular Differentiation of Immunoregulatory Natural T Lymphocytes Aleksandar K. Stanic, Jelena S. Bezbradica, Jang-June Park, Naoto Matsuki, Ana L. Mora, Luc Van Kaer, Mark R. Boothby, and Sebastian Joyce

2265-2273

Adjuvant Costimulation during Secondary Antigen Challenge Directs Qualitative Aspects of Oral Tolerance Induction, Particularly during the Neonatal Period Iriani T. Tobagus, Wayne R. Thomas, and Patrick G. Holt

2274-2285

CD4+ T Cells Regulate CD8+ T Cell-Mediated Cutaneous Immune Responses by Restricting Effector T Cell Development through a Fas Ligand-Dependent Mechanism Anton V. Gorbachev and Robert L. Fairchild

2286-2295

Reduced Thymocyte Development in Sonic Hedgehog Knockout Embryos Divya K. Shah, Ariadne L. Hager-Theodorides, Susan V. Outram, Susan E. Ross, Alberto Varas, and Tessa Crompton

2296-2306

MOLECULAR AND STRUCTURAL IMMUNOLOGY Dendritic Cell Maturation Requires STAT1 and Is under Feedback Regulation by Suppressors of Cytokine Signaling Sharon H. Jackson, Cheng-Rong Yu, Rashid M. Mahdi, Samuel Ebong, and Charles E. Egwuagu

2307-2315

Caspase-3 Is a Component of Fas Death-Inducing Signaling Complex in Lipid Rafts and Its Activity Is Required for Complete Caspase-8 Activation during Fas-Mediated Cell Death Salah M. Aouad, Luchino Y. Cohen, Ehsan Sharif-Askari, Elias K. Haddad, Antoine Alam, and Rafick-Pierre Sekaly

2316-2323

The Impact of Self-Tolerance on the Polyclonal CD8+ T Cell Repertoire Helmut W. H. G. Kessels, Karin E. de Visser, Felicia H. Tirion, Miriam Coccoris, Ada M. Kruisbeek, and Ton N. M. Schumacher

2324-2331

Activation of Discoidin Domain Receptor 1 Isoform b with Collagen 2332-2340

Up-Regulates Chemokine Production in Human Macrophages: Role of p38 Mitogen-Activated Protein Kinase and NF-B Wataru Matsuyama, Lihua Wang, William L. Farrar, Michel Faure, and Teizo Yoshimura Immunosuppressive Activity of Endovanilloids: N-Arachidonoyl-Dopamine Inhibits Activation of the NF-B, NFAT, and Activator Protein 1 Signaling Pathways Rocío Sancho, Antonio Macho, Laureano de La Vega, Marco A. Calzado, Bernd L. Fiebich, Giovanni Appendino, and Eduardo Muñoz

2341-2351

Molecular Characterization of Human 4Ig-B7-H3, a Member of the B7 Family with Four Ig-Like Domains Peter Steinberger, Otto Majdic, Sophia V. Derdak, Katharina Pfistershammer, Stefanie Kirchberger, Christoph Klauser, Gerhard Zlabinger, Winfried F. Pickl, Johannes Stöckl, and Walter Knapp

2352-2359

Biases in Ig Light Chain Rearrangements in Human Intestinal Plasma Cells Wen Su, Laurent Boursier, Archana Padala, Jeremy D. Sanderson, and Jo Spencer

2360-2366

Conformation and Glycosylation of a Megalin Fragment Correlate with Nephritogenicity in Heymann Nephritis Alfonso Tramontano and Sudesh P. Makker

2367-2373

FcRI-ITAM Is Differentially Required for Mast Cell Function In Vivo Daiju Sakurai, Sho Yamasaki, Kanako Arase, Seung Yong Park, Hisashi Arase, Akiyoshi Konno, and Takashi Saito

2374-2381

The Crystal Structure of Human CD1b with a Bound Bacterial Glycolipid Thil Batuwangala, Dawn Shepherd, Stephan D. Gadola, Kevin J. C. Gibson, Nathan R. Zaccai, Alan R. Fersht, Gurdyal S. Besra, Vincenzo Cerundolo, and E. Yvonne Jones

2382-2388

Activation/Division of Lymphocytes Results in Increased Levels of Cytoplasmic Activation/Proliferation-Associated Protein-1: Prototype of a New Family of Proteins Brock Grill, Gary M. Wilson, Kai-Xin Zhang, Bin Wang, Regis Doyonnas, Manfredo Quadroni, and John W. Schrader

2389-2400

HOST DEFENSE Antibody-Dependent Cellular Cytotoxicity via Humoral Immune Epitope of Nef Protein Expressed on Cell Surface Takeshi Yamada, Nobukazu Watanabe, Tetsuya Nakamura, and Aikichi Iwamoto

2401-2406

Macrophages, CD4+ or CD8+ Cells Are Each Sufficient for Protection against Chlamydia pneumoniae Infection through their Ability to Secrete IFN- Antonio Gigliotti Rothfuchs, Maria Regina Kreuger, Hans Wigzell, and Martin E. Rottenberg

2407-2415

Calcium and Its Role in the Nuclear Translocation and Activation of Cytosolic Phospholipase A2 in Cells Rendered Sensitive to TNF-Induced Apoptosis by Cycloheximide David W. Draper, Virginia G. Harris, Carolyn A. Culver, and Scott M. Laster

2416-2423

Peripheral CD4 T Cells Rapidly Accumulate at the Host:Parasite 2424-2430

Interface during an Inflammatory Th2 Memory Response Motoko Morimoto, Masahiro Morimoto, Jeannette Whitmire, Shiyun Xiao, Robert M. Anthony, Hiroshi Mirakami, Robert A. Star, Joseph F. Urban, Jr, and William C. Gause Haemophilus influenzae Type b-Outer Membrane Protein Complex Glycoconjugate Vaccine Induces Cytokine Production by Engaging Human Toll-Like Receptor 2 (TLR2) and Requires the Presence of TLR2 for Optimal Immunogenicity Eicke Latz, Jennifer Franko, Douglas T. Golenbock, and John R. Schreiber

2431-2438

Parasite Antigen-Driven Basophils Are a Major Source of IL-4 in Human Filarial Infections Edward Mitre, Rebekah T. Taylor, Joseph Kubofcik, and Thomas B. Nutman

2439-2445

The Zinc Finger Mutation C417R of I-B Kinase Impairs Lipopolysaccharide- and TNF-Mediated NF-B Activation through Inhibiting Phosphorylation of the I-B Kinase Activation Loop Fan Yang, Junro Yamashita, Eric Tang, Hom-lay Wang, Kunliang Guan, and Cun-Yu Wang

2446-2452

Recognition of Homo- and Heterosubtypic Variants of Influenza A Viruses by Human CD8+ T Lymphocytes Adrianus C. M. Boon, Gerrie de Mutsert, Debbie van Baarle, Derek J. Smith, Alan S. Lapedes, Ron A. M. Fouchier, Kees Sintnicolaas, Albert D. M. E. Osterhaus, and Guus F. Rimmelzwaan

2453-2460

Protective Immunization against Group B Meningococci Using Anti-Idiotypic Mimics of the Capsular Polysaccharide Concetta Beninati, Simona Arseni, Giuseppe Mancuso, Walter Magliani, Stefania Conti, Angelina Midiri, Carmelo Biondo, Luciano Polonelli, and Giuseppe Teti

2461-2468

Cyclooxygenase-2-Mediated Prostaglandin E2 Production in Mesenteric Lymph Nodes and in Cultured Macrophages and Dendritic Cells after Infection with Salmonella Christal C. Bowman and Kenneth L. Bost

2469-2475

HIV-1-Specific Memory CD4+ T Cells Are Phenotypically Less Mature Than Cytomegalovirus-Specific Memory CD4+ T Cells Feng Yun Yue, Colin M. Kovacs, Rowena C. Dimayuga, Paul Parks, and Mario A. Ostrowski

2476-2486

Protective T Cell Immunity against Malaria Liver Stage after Vaccination with Live Sporozoites under Chloroquine Treatment Elodie Belnoue, Fabio T. M. Costa, Tobias Frankenberg, Ana Margarida Vigário, Tatiana Voza, Nicolas Leroy, Mauricio M. Rodrigues, Irène Landau, Georges Snounou, and Laurent Rénia

2487-2495

Liver Dendritic Cells Present Bacterial Antigens and Produce Cytokines upon Salmonella Encounter Cecilia Johansson and Mary Jo Wick

2496-2503

INFLAMMATION Suppression of Osteoprotegerin Expression by Prostaglandin E2 Is Crucially Involved in Lipopolysaccharide-Induced Osteoclast Formation Koji Suda, Nobuyuki Udagawa, Nobuaki Sato, Masamichi Takami, Kanami Itoh, Je-Tae Woo, Naoyuki Takahashi, and Kazuo Nagai

2504-2510

TNF Receptor Signaling Contributes to Chemokine Secretion, Inflammation, and Respiratory Deficits during Pneumocystis Pneumonia Terry W. Wright, Gloria S. Pryhuber, Patricia R. Chess, Zhengdong Wang, Robert H. Notter, and Francis Gigliotti

2511-2521

Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-B Karim Asehnoune, Derek Strassheim, Sanchayita Mitra, Jae Yeol Kim, and Edward Abraham

2522-2529

B7-DC Regulates Asthmatic Response by an IFN--Dependent Mechanism Koichiro Matsumoto, Hiromasa Inoue, Takako Nakano, Miyuki Tsuda, Yuki Yoshiura, Satoru Fukuyama, Fumihiko Tsushima, Tomoaki Hoshino, Hisamichi Aizawa, Hisaya Akiba, Drew Pardoll, Nobuyuki Hara, Hideo Yagita, Miyuki Azuma, and Yoichi Nakanishi

2530-2541

Role of Bradykinin B2 and B1 Receptors in the Local, Remote, and Systemic Inflammatory Responses That Follow Intestinal Ischemia and Reperfusion Injury Danielle G. Souza, Eliane S. L. Lomez, Vanessa Pinho, João Bosco Pesquero, Michael Bader, Jorge Luís Pesquero, and Mauro M. Teixeira

2542-2548

Contribution of Antigen-Primed CD8+ T Cells to the Development of Airway Hyperresponsiveness and Inflammation Is Associated with IL-13 Nobuaki Miyahara, Katsuyuki Takeda, Taku Kodama, Anthony Joetham, Christian Taube, Jung-Won Park, Satoko Miyahara, Annette Balhorn, Azzeddine Dakhama, and Erwin W. Gelfand

2549-2558

Microtubule-Associated Serine/Threonine Kinase-205 kDa and Fc Receptor Control IL-12 p40 Synthesis and NF-B Activation Hui Zhou, Huabao Xiong, Hongxing Li, Scott E. Plevy, Paul D. Walden, Massimo Sassaroli, Glenn D. Prestwich, and Jay C. Unkeless

2559-2568

Inhibition of c-Jun NH2-Terminal Kinase Activity Improves Ischemia/Reperfusion Injury in Rat Lungs Makoto Ishii, Yukio Suzuki, Kei Takeshita, Naoki Miyao, Hiroyasu Kudo, Rika Hiraoka, Kazumi Nishio, Nagato Sato, Katsuhiko Naoki, Takuya Aoki, and Kazuhiro Yamaguchi

2569-2577

Peptide-Mediated Inhibition of Neutrophil Transmigration by Blocking CD47 Interactions with Signal Regulatory Protein Yuan Liu, Miriam B. O’Connor, Kenneth J. Mandell, Ke Zen, Axel Ullrich, Hans-Jörg Bühring, and Charles A. Parkos

2578-2585

Matrix Metalloproteinase-9 Deficiency Results in Enhanced Allergen-Induced Airway Inflammation Sarah J. McMillan, Jennifer Kearley, J. Darren Campbell, Xing-Wu Zhu, Karen Y. Larbi, J. Michael Shipley, Robert M. Senior, Sussan Nourshargh, and Clare M. Lloyd

2586-2594

Inflammatory Gene Profiles in Gastric Mucosa during Helicobacter pylori Infection in Humans Sicheng Wen, Christian P. Felley, Hanifa Bouzourene, Mark Reimers, Pierre Michetti, and Qiang Pan-Hammarström

2595-2606

Key Roles of CD4+ T Cells and IFN- in the Development of Abdominal Aortic Aneurysms in a Murine Model Wanfen Xiong, Yong Zhao, Amy Prall, Timothy C. Greiner, and B.

2607-2612

Timothy Baxter Inhibition of IL-10 Receptor Function in Alveolar Macrophages by Toll-Like Receptor Agonists Stefan Fernandez, Purnima Jose, Margarita G. Avdiushko, Alan M. Kaplan, and Donald A. Cohen

2613-2620

Construction of Hevein (Hev b 6.02) with Reduced Allergenicity for Immunotherapy of Latex Allergy by Comutation of Six Amino Acid Residues on the Conformational IgE Epitopes Piia Karisola, Jari Mikkola, Nisse Kalkkinen, Kari J. Airenne, Olli H. Laitinen, Susanna Repo, Olli T. Pentikäinen, Timo Reunala, Kristiina Turjanmaa, Mark S. Johnson, Timo Palosuo, Markku S. Kulomaa, and Harri Alenius

2621-2628

Role of Toll-Like Receptor 4 in Endotoxin-Induced Acute Renal Failure Patrick N. Cunningham, Ying Wang, Rongqing Guo, Gang He, and Richard J. Quigg

2629-2635

CLINICAL IMMUNOLOGY Respective Roles of Decay-Accelerating Factor and CD59 in Circumventing Glomerular Injury in Acute Nephrotoxic Serum Nephritis Feng Lin, David J. Salant, Howard Meyerson, Steven Emancipator, B. Paul Morgan, and M. Edward Medof

2636-2642

TNF- Coupled to Membrane of Apoptotic Cells Favors the Cross-Priming to Melanoma Antigens Valérie S. Zimmermann, Attilio Bondanza, Antonella Monno, Patrizia Rovere-Querini, Angelo Corti, and Angelo A. Manfredi

2643-2650

A Spontaneous Model for Autoimmune Myocarditis Using the Human MHC Molecule HLA-DQ8 Jacqueline A. Taylor, Evis Havari, Marcia F. McInerney, Roderick Bronson, Kai W. Wucherpfennig, and Myra A. Lipes

2651-2658

In Vivo Evidence That Peptide Vaccination Can Induce HLA-DR-Restricted CD4+ T Cells Reactive to a Class I Tumor Peptide Mamoru Harada, Rumi Gohara, Satoko Matsueda, Akira Muto, Tatsuya Oda, Yoshiko Iwamoto, and Kyogo Itoh

2659-2667

Pulmonary Edema Fluid from Patients with Early Lung Injury Stimulates Fibroblast Proliferation through IL-1-Induced IL-6 Expression Mitchell A. Olman, Kimberly E. White, Lorraine B. Ware, Warren L. Simmons, Etty N. Benveniste, Sha Zhu, Jerome Pugin, and Michael A. Matthay

2668-2677

CD40 Ligand Dysregulation in HIV Infection: HIV Glycoprotein 120 Inhibits Signaling Cascades Upstream of CD40 Ligand Transcription Rui Zhang, Carl J. Fichtenbaum, David A. Hildeman, Jeffrey D. Lifson, and Claire Chougnet

2678-2686

HIV-1 Does Not Provoke Alteration of Cytokine Gene Expression in Lymphoid Tissue after Acute Infection Ex Vivo Annette Audigé, Erika Schlaepfer, Athos Bonanomi, Helene Joller, Marlyse C. Knuchel, Markus Weber, David Nadal, and Roberto F. Speck

2687-2696

Breakdown of Tolerance to a Self-Peptide of Acetylcholine Receptor -Subunit Induces Experimental Myasthenia Gravis in Rats

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Fulvio Baggi, Andrea Annoni, Federica Ubiali, Monica Milani, Renato Longhi, Widmer Scaioli, Ferdinando Cornelio, Renato Mantegazza, and Carlo Antozzi CORRECTIONS Molecular Cloning and Immunologic Characterization of a Novel cDNA Coding for Progesterone-Induced Blocking Factor Beata Polgar, Gyula Kispal, Margit Lachmann, Gabriella Paar, Eszter Nagy, Peter Csere, Eva Miko, Laszlo Szereday, Peter Varga, and Julia Szekeres-Bartho

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The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-Induced T Cell Polarization Donald J. Davidson, Andrew J. Currie, Gregor S. D. Reid, Dawn M. E. Bowdish, Kelly L. MacDonald, Rebecca C. Ma, Robert E. W. Hancock, and David P. Speert

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Chemokine Secretion of Rheumatoid Arthritis Synovial Fibroblasts Stimulated by Toll-Like Receptor 2 Ligands Matthias Pierer, Janine Rethage, Reinhart Seibl, Roger Lauener, Fabia Brentano, Ulf Wagner, Holm Hantzschel, Beat A. Michel, Renate E. Gay, Steffen Gay, and Diego Kyburz

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