Introduction of LivactorDLG]_Vitamin stabilization... · 2014-12-17 · Pigment cell: makes melanin...
Transcript of Introduction of LivactorDLG]_Vitamin stabilization... · 2014-12-17 · Pigment cell: makes melanin...
Introduction of Vitamin Stabilization Technology of C-SEM
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DAELIM GLOBAL Co., Ltd, 14F Noonnoppi Daejeon Center 1028 Doonsan 2-dong, Seo-gu Daejeon, South Korea 302-828
http://www.daelimglobal.com T : F : E:
82. 42. 476. 9400 82. 42. 476. 9401 [email protected]
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Skin is consisted with various layers and each layer has various cells. So understanding roles of each cell is needed to find right solution of various skin problems
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Epi- dermis
Dermis
Hypo-dermis
The most outer part of skin
Stratum basal: cell division & replacement
Pigment cell: makes melanin which
effects on skin color decision
Fibroblast: makes Collagen & Elastin
which keep skin elasticity
Sebaceous glands: emits sebum to
protect virus invasion & moisture dry
Ground substance: contains plenty of
moisture and fills among cells
Located between Dermis and muscle &
bones
It contains thick fat layer to protect from
outer impact and keep body temperature
Elastin
Fibroblast
Background Knowledge - (1) Understanding of Skin
(1) Skin’s Structure & Role1)
Hypo-dermis
Pigment cell(melanocyte)
Sebaceous glands
Follicles Sweat pore Blood Vessel
Collagen
Ground substance
Stratum basal
Epi- dermis
Dermis
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Skin aging causes various skin problems and it is divided unavoidable Intrinsic Factor and restorable Extrinsic Factor by functional cosmetics
Causes of Skin aging1) Major Skin Problems by Skin Aging
(2) Causes & Results of Skin aging
Intrinsic Factor
Extrinsic Factor
Natural aging by time and mostly decided by
genetic factor
Oxygen free radical is known as a direct reason
to generate skin aging
Aging generated by extrinsic factor such as
UV rays, pollution, severe weather, and
cigarette smoke etc.
Photoaging by UV rays is the typical case
UV rays A>B>C (Longer wavelength in order)
UV-A & B have bad influence on skin problems
Background Knowledge - (2) Causes & Results of Skin aging 1
Decrease of skin depth & elasticity, wrinkle
Destruction and decrease of collagen & elastin
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Pigmentation & spot generation
Over generation of melanin by exposure to UV
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Dryness skin
Decreased sebum to protect virus & moisture loss
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Skin infection and skin cancer increase
Increase skin disease factors by decreased immunity
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Abnormal calcium metabolic activity
Decrease of Vitamin D to accumulate calcium on bones
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Areas to be improved by functional cosmetics
“Not easy to overcome by effort”
“Possible to improve by effort”
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Vitamin is an organic compound required by an organism as a vital nutrient in limited amounts
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(3) Relation between vitamin & skin
Background Knowledge - (3) Relation between vitamin & skin
Vitamins
Vitamin A Vitamin B Vitamin C Vitamin D Vitamin E
• Roles : 1) Callus Prevention 2) Skin Elasticity Increase 3) Anti Infectious Ability
• Deficiency : 1) Hypodermis Atrophy 2) Skin Dryness 3) Thick Skin
• Foods : Spinach, Carrot, Cabbage
• Roles : 1) Immune Sys. Protection 2) UV Protection 3) Anti-skin Cancer
• Deficiency : 1) Skin Cancer
• Foods : Peanut, Salmon, Bean
• Roles : 1) Activated O2 Removal 2) Sun-ray Protection 3) Collagen Generation 4) Whitening
• Deficiency : 1) Stains 2) Freckles
• Foods :
Apple, Apricot, Strawberry
• Roles : 1) Skin Dryness Prevention
• Deficiency : 1) Skin Aging
• Foods : Milk, Cheese, Mushroom
• Roles : 1) Anti-vaporizing 2) Skin Reproduction 3) Moisturizing
• Deficiency : 1) Skin Aging
• Foods : Vegetable oil, Grain
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Skin Problem Cause Solution Principle of improvement
Intrinsic Aging • Cell damage by oxygen free radical
Vitamin C Vitamin E
• Vitamin C & E removes Oxygen free radical and maximize anti-oxidant activity by both interaction
Extrinsic Aging • Cell damage by UV A, B Vitamin C Vitamin E
• Vitamin C protects cell damage by UV & skin cancer • Vitamin E protects cell damage by fat oxidation
Skin depth & elasticity decrease • Collagen & elastin decrease
Vitamin A Vitamin C
• Vitamin A’s retinol keeps fibroblast healthy • Vitamin C motivates collagen & elastin generation
Wrinkle Generation
• MMP1) enzyme increase which demolishes protein which is composing ground substance
Vitamin A • Vitamin A’s retinol restrains MMP enzyme generation not to demolish protein
Pigmentation & spot generation
• Irregular pigment dispersion & maturity by melanin cell generation
Vitamin C • Vitamin C restrains melanin generation and revivify generated melanin & get paled the color
Dryness skin • Increase moisture loss by sebum secretion decrease
Vitamin B Vitamin E
• Vitamin B’s panthenol keeps skin moisture & shine • Vitamin E restrains fat oxidation and moisture evaporation
Vitamin is used to solve skin problems especially Vitamin-C is used for various skin problems
(4) Solutions of skin problem
1) Matrix metalloproteinase,
Background Knowledge - (4) Solutions of skin problem 1
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Vitamin C is very beneficial for skin care but pure Vitamin C is very difficult to use as a raw material of cosmetic so far
(5) Pros & Cons of Vitamin C
1) phosphate ester, fatty acid ester
Background Knowledge - (5) Pros & Cons of Vitamin C 1
Effectiveness of Vitamin-C Limitation of Vitamin-C
Anti-aging
Wrinkle
Care
• Prevents generation of activated oxygen which
affects on skin barrier damage, pigmentation
and aging
Whitening
Skin Problem
Care
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2
3
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• Restricts melanin synthetic and restores skin
tone clearly & whitely through oxidized melanin
reduction
• Stabilizes collagen which affect on skin elasticity
& moisturizing for pore tightening, wrinkle free
skin and elastic skin
• Strengthens skin’s defense mechanism against
germs and skin barrier to solve skin problems
such as an atopic dermatitis
Easy decomposition by heat & air
Pure Vitamin C can’t be used as raw materials of
cosmetic even it has strong antioxidant ability
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Body can’t synthesize Vitamin C
Vitamin C must be supplied out of the body through
eating foods which contains Vitamin C
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Unclear effectiveness of derivatives
Vitamin derivative1) is for supporting weakness of pure
Vitamin C but conversion efficiency is not clear
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“Using Vitamin C as raw material
of cosmetic is difficult so far”
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Product Comparison - (1) Cellex-C - A. Introduction
Cellex-C is the best selling skin care cosmetic world widely and it owns head quarter in Canada & manufacturing plant in USA
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A. Introduction
1) www.cellex-c.com
“ The best selling
Vitamin-C cosmetic
in the world
BUT
Is it perfect product
as much as
its fame & price?”
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“FAQ of Cellex-C from Korean Official Website”
Cellex-C has asked questions frequently regarding discoloration, make-up scrubbing, skin sting, and dryness skin. BUT all causes are explained as nature of Vitamin-C
B. Quality issue
1) www.cellex-c.co.kr
Q: Why is the color of CelleX-C is different from others which bought before? A: It because of different date of raw material collecting → QC standard must be applied equally so we can guess it because of discoloration & decomposition
Q: Why Moisturizer & make-up is scrubbed like dead skin after using Vitamin C & Hydra 5-B Complex? A: It because of inharmony between water based Cellex-C and other oil based product. → We can guess it because of low absorption ability of Vitamin-C product of Cellex-C
Q: Why skin is stung and dried when using Vitamin-C of Cellex-C especially using Cream product? A: It is natural phenomenon when Vitamin-C is penetrating Skin, Cream type has slower absorption ability so it stays longer on the skin. → It is natural thing of Vitamin-C, BUT it can be improved according to Vitamin-C stabilization tech. like ours
Product Comparison - (1) Cellex-C - B. Quality issue 2
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Not only Cellex-C but also other Vitamin based products have similar problems as well BUT these problems can be improved by our VITAMIN STABILIZATION TECHNOLOGY
Own Patent1)
Definition of Stabilization Tech
Product Comparison - (2) C-SEM - A. Vitamin Stabilization Tech. (1) 2
Coated antioxidant particle, Composition comprising the particle and Method for preparing the particle (2009.07.07 10-0907660)
Coated antioxidant particle, Composition comprising the particle and Method for preparing the particle (2009.11.25 10-0929703)
Aqueous cosmetic composition comprising coated antioxidant particle and Method for preparing the particle (2010.06.22 10-0966919)
1) http://eng.kipris.or.kr
Stabilization Technology
Definition
Capsule Structure
Effectiveness
• Pure Vitamin C can be existed in cosmetic stably
without oxidization from light, heat and air
• Thus skin penetration of Vitamin C is increased
• Uses stabilizer which can be polymer by itself as
a capsule material to encapsulate pure Vitamin C
and protect the Vitamin C from decomposition
Vitamin C Stabilizer
Silica Bio Polymer
Applied patent to Vitamin C stabilization
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Our capsulated Vitamin C showed higher residual contents and lower discolor ability compare to pure Vitamin C
Residual contents test in cosmetic Vitamin C discoloration test
Residual contents test & discoloration test
1) Korea Health Supplement Institute, www.khsi.re.kr
0
20
40
60
80
100
Time(week)
0
1
2.5
10
25
Vitam
in
Conce
ntr
ate(
%)
Product Comparison - (2) C-SEM - A. Vitamin Stabilization Tech. (2) 2
1 Week 2 Week 3 Week 4 Week 0 Week
Pure VC
Our VC
1) More effectiveness by pure VC penetration
2) Bio contents helps moisturizing & skin penetration
3) It showed over 94% stability at 50℃ (Clinical test)
1) Decomposed Vitamin causes skin stimulation
2) Pure VC was discolored even stored in refrigerator
3) Our VC kept initial color for 4 weeks
Pure VC Capsulated VC
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Capsulated pure Vitamin C showed twice higher skin penetration ability than non-capsulated vitamin C
Skin penetrate test
2 Product Comparison - (2) C-SEM - A. Vitamin Stabilization Tech. (3)
Pure Vitamin C skin penetration test
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Cellex-C is the best Vitamin C but it can’t solve fundamental problems of Vitamin C BUT we solved this problems with our stabilization technology
Comparison Cellex-C and C-SEM comparison
Product Comparison - (3) Comparison 2
Cellex(5%Vc) C-SEM(5%Vc)
Case Image
Quantity 15ml 20ml
Issues
• Discolor and decomposition generation • Skin stimulus generation • Dryness skin generation • Make-up scrubbing generation • Lack of clinical data • Expensive
• Non-preservative, Non-pigment, Non-perfume (Natural oil use)
• Owns Vitamin Stabilization Tech. patent • Maximized skin penetration using natural vegetable oil
Discolor and
Residue contents1)
Normal Spoid Case
Pump type high-end case
Side window to check inside
1) Measuring for 4 weeks at 50℃
0 Week 100%
(Initial Stage)
4 Week
62%
0 Week 100%
(Initial Stage)
4 Week
94.2%
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Pure Vitamin C based Serum
Normally pure vitamin c is good to skin problem but it has low ph than skin’s ph
So the gap of pH can cause skin stimulus(BUT Our serum has solved this problem)
This serum is effective for whitening, wrinkle free, moisturizing and dead cell removal
with its strong anti-oxidant activity
Vitamin C stabilization is possible through our own stabilization technology
To prove our Vitamin stabilization tech. we compared pure Vitamin based sample A and vitamin derivative based sample B
(1) Comparison
-
-
Age Planner
Warming Serum
(Sample A)
Muriel White
Perfection Vitamin C
Serum (Sample B)
Recognized the best Vitamin C Derivative AA2G
Vitamin C Derivative has 80% similar effectiveness of pure Vitamin C
But Vitamin C Derivative has normal pH level enough to supplement Pure Vitamin C
So it is widely applied to make cosmetics as the alternative of unstable Pure Vitamin C
This serum was approved as a functional cosmetic by MDFA1)
Appendix - Pure Vitamin C & Vitamin Derivatives - (1) Comparison 3
1) Ministry of Food and Drug Safety, www.mfds.go.kr
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Both pure Vitamin and Vitamin Derivatives can be effective solutions for skin problems BUT pure Vitamin showed better effectiveness than Vitamin Derivatives
(2) Clinical Test
3 Appendix - Pure Vitamin C & Vitamin Derivatives - (2) Clinical Test
63.0 62.5 62.0 61.5 61.0 60.5 60.0 59.5 59.0 58.5 58.0
Sample B Sample A
0 W 3 W 6 W
Skin color change (higher is better)
Wrinkle depth (Lower is better) 63.0 62.5 62.0 61.5 61.0 60.5 60.0 59.5 59.0 58.5 58.0 0 W 3 W 6 W
Sample A Sample B
62.5
62.0
61.5
61.0
60.5
60.0
59.5 0 W 3 W 6 W
Dead skin Qt. (lower is better) 63.0 Sample B Sample A
205.0
200.0
195.5
190.0
185.5
180.0
175.5
170.0 0 W 3 W 6 W
Melanin level (Lower is better)
Sample B Sample A
Moisturizing (Higher is better) 66.0 64.0 62.0 60.0 58.0
54.0 52.0 50.0
56.0
0 W 3 W 6 W
Sample B Sample A
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Pure Vitamin C based Age Planner Warming Serum showed its effectiveness for facial blemishes removal through 6 weeks test
(3) Facial blemishes
“Facial blemishes are decreased through 6 weeks test by stabilized Vitamin C”
Product Image 0 W 3 W 6 W
Sample (A)
Cross-polarized
Black component
Appendix - Pure Vitamin C & Vitamin Derivatives - (3) Facial blemishes 3
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Through our stabilization technology, pure Vitamin C can be used as cosmetic material WITHOUT existing problems so the customers can expect improved effectiveness
(4) Conclusion
“ Through our Stabilization technology, direct use of Vitamin-C is possible”
Sample A : Stabilized Vitamin C
Sample B : Vitamin Derivatives
AA2G [KFDA approval] Results
Skin Color Very Effective Effective Sample A showed better result than Sample B
in skin color improvement
Melanin Level Very Effective Effective Sample A showed better result than Sample B
in decrease of blemished and spots
Wrinkles Very Effective Effective Sample A showed better result than Sample B
in wrinkle decrease
Moisturizing Effective Effective Sample A showed better result than Sample B
In moisturizing
Dead Skin Removal
Effective Effective Sample A showed better result than Sample B
In dead skin decrease
Skin Stimulus No Stimulus No Stimulus Clinical Test Success
Appendix - Pure Vitamin C & Vitamin Derivatives - (4) Conclusion 3