International Evaluation of Research and Doctoral Training ...

Evaluation Panel: Medicine, Biomedicine and Health Sciences

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI 2005–2010

RC-Specific Evaluation of CompDisGen – Complex Disease Genomics Group Seppo Saari & Antti Moilanen (Eds.)

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI 2005–2010

RC-Specific Evaluation of CompDisGen – Complex Disease Genomics Group Seppo Saari & Antti Moilanen (Eds.)

University of Helsinki Administrative Publications 80/34 Evaluations

2012

Publisher: University of Helsinki

Editors: Seppo Saari & Antti Moilanen

Title: International Evaluation of Research and Doctoral Training at the University of Helsinki 2005–2010 : RC-Specific Evaluation of CompDisGen – Complex Disease Genomics Group

Type of publication: Evaluations

Summary: Researcher Community (RC) was a new concept of the participating unit in the evaluation. Participation in the evaluation was voluntary and the RCs had to choose one of the five characteristic categories to participate. Evaluation of the Researcher Community was based on the answers to the evaluation questions. In addition a list of publications and other activities were provided by the TUHAT system. The CWTS/Leiden University conducted analyses for 80 RCs and the Helsinki University Library for 66 RCs. Panellists, 49 and two special experts in five panels evaluated all the evaluation material as a whole and discussed the feedback for RC-specific reports in the panel meetings in Helsinki. The main part of this report is consisted of the feedback which is published as such in the report. Chapters in the report: 1. Background for the evaluation 2. Evaluation feedback for the Researcher Community 3. List of publications 4. List of activities 5. Bibliometric analyses The level of the RCs’ success can be concluded from the written feedback together with the numeric evaluation of four evaluation questions and the category fitness. More conclusions of the success can be drawn based on the University-level report.

RC-specific information:

Main scientific field of research: Medicine, Biomedicine and Health Sciences Participation category: 1. Research of the participating community represents the international cutting edge in its field RC’s responsible person: Kaprio, Jaakko

RC-specific keywords: gene, mutation, genetics, genomics, linkage, association, disease, complex trait, pedigree, human, dog, mouse, cardiovascular disease, autoimmune disease, migraine, epilepsy, psychiatric disease, asthma, dyslexia, hypertension, obesity, metabolic disorder, substance abuse disorder, copy number variation, mapping, GWAS, SNP, polymorphic, linear regression, comparative genetics, animal model, bioinformatics, systems biology, meta-analysis

Keywords: Research Evaluation, Meta-evaluation, Doctoral Training, Bibliometric Analyses, Researcher Community

Series title and number: University of Helsinki, Administrative Publications 80/34, Evaluations

ISSN: 1795-5513 (Online)

ISBN: 978-952-10-7454-7 (PDF)

Total number of pages: 139

Language: English

Additional information: Cover graphics: Päivi Talonpoika-Ukkonen Enquiries: [email protected]

Internet address: http://www.helsinki.fi/julkaisut/aineisto/rc_evaluation2012/hallinnon_julkaisuja_80_34_2012.pdf

Contents Panel members ........................................................................................................................... 1 1 Introduction to the Evaluation ............................................................................................... 5

1.1 RC-specific evaluation reports .......................................................................................................... 5 1.2 Aims and objectives in the evaluation ............................................................................................... 5 1.3 Evaluation method ............................................................................................................................ 5 1.4 Implementation of the external evaluation ........................................................................................ 6 1.5 Evaluation material ........................................................................................................................... 7 1.6 Evaluation questions and material .................................................................................................... 8 1.7 Evaluation criteria ........................................................................................................................... 10 1.8 Timetable of the evaluation ............................................................................................................. 13 1.9 Evaluation feedback – consensus of the entire panel ..................................................................... 13

2 Evaluation feedback .............................................................................................................. 15 2.1 Focus and quality of the RC’s research .......................................................................................... 15 2.2 Practises and quality of doctoral training ........................................................................................ 15 2.3 The societal impact of research and doctoral training ..................................................................... 16 2.4 International and national (incl. intersectoral) research collaboration and researcher mobility ....... 16 2.5 Operational conditions .................................................................................................................... 16 2.6 Leadership and management in the researcher community ........................................................... 17 2.7 External competitive funding of the RC ........................................................................................... 17 2.8 The RC’s strategic action plan for 2011–2013 ................................................................................ 18 2.9 Evaluation of the category of the RC in the context of entity of the evaluation material (1-8) ......... 18 2.10 Short description of how the RC members contributed the compilation of the stage 2 material ... 18 2.11 How the UH’s focus areas are presented in the RC’s research .................................................... 18 2.12 RC-specific main recommendations ............................................................................................. 18 2.13 RC-specific conclusions ................................................................................................................ 18 2.14 Preliminary findings in the Panel-specific feedback ...................................................................... 19 2.15 Preliminary findings in the University-level evaluation .................................................................. 20

3 Appendices ............................................................................................................................ 21

Foreword The evaluation of research and doctoral training is being carried out in the years 2010–2012 and will end in 2012. The steering group appointed by the Rector in January 2010 set the conditions for participating in the evaluation and prepared the Terms of Reference to present the evaluation procedure and criteria. The publications and other scientific activities included in the evaluation covered the years 2005–2010.

The participating unit in the evaluation was defined as a Researcher Community (RC). To obtain a critical mass with university-level impact, the number of members was set to range from 20 to 120. The RCs were required to contain researchers in all stages of their research career, from doctoral students to principal investigators (PIs). All in all, 136 Researcher Communities participated in this voluntary evaluation, 5857 persons in total, of whom 1131 were principal investigators. PIs were allowed to participate in two communities in certain cases, and 72 of them used this opportunity and participated in two RCs.

This evaluation enabled researchers to define RCs from the “bottom up” and across disciplines. The aim of the evaluation was not to assess individual performance but a community with shared aims and researcher-training activities. The RCs were able to choose among five different categories that characterised the status and main aims of their research. The steering group considered the process of applying to participate in the evaluation to be important, which lead to the establishment of these categories. In addition, providing a service for the RCs to enable them to benchmark their research at the global level was a main goal of the evaluation.

The data for the evaluation consisted of the RCs’ answers to evaluation questions on supplied e-forms and a compilation extracted from the TUHAT – Research Information System (RIS) on 12 April 2011. The compilation covered scientific and other publications as well as certain areas of scientific activities. During the process, the RCs were asked to check the list of publications and other scientific activities and make corrections if needed. These TUHAT compilations are public and available on the evaluation project sites of each RC in the TUHAT-RIS.

In addition to the e-form and TUHAT compilation, University of Leiden (CWTS) carried out bibliometric analyses from the articles included in the Web of Science (WoS). This was done on University and RC levels. In cases where the publication forums of the RC were clearly not represented by the WoS data, the Library of the University of Helsinki conducted a separate analysis of the publications. This was done for 66 RCs representing the humanities and social sciences.

The evaluation office also carried out an enquiry targeted to the supervisors and PhD candidates about the organisation of doctoral studies at the University of Helsinki. This and other documents describing the University and the Finnish higher education system were provided to the panellists.

The panel feedback for each RC is unique and presented as an entity. The first collective evaluation reports available for the whole panel were prepared in July–August 2011. The reports were accessible to all panel members via the electronic evaluation platform in August. Scoring from 1 to 5 was used to complement written feedback in association with evaluation questions 1–4 (scientific focus and quality, doctoral training, societal impact, cooperation) and in addition to the category evaluating the fitness for participation in the evaluation. Panellists used the international level as a point of comparison in the evaluation. Scoring was not expected to go along with a preset deviation.

Each of the draft reports were discussed and dealt with by the panel in meetings in Helsinki (from 11 September to 13 September or from 18 September to 20 September 2011). In these meetings the panels also examined the deviations among the scores and finalised the draft reports together.

The current RC-specific report deals shortly with the background of the evaluation and the terms of participation. The main evaluation feedback is provided in the evaluation report, organised according to the evaluation questions. The original material provided by the RCs for the panellists has been attached to these documents.

On behalf of the evaluation steering group and office, I sincerely wish to thank you warmly for your

participation in this evaluation. The effort you made in submitting the data to TUHAT-RIS is gratefully acknowledged by the University. We wish that you find this panel feedback useful in many ways. The bibliometric profiles may open a new view on your publication forums and provide a perspective for discussion on your choice of forums. We especially hope that this evaluation report will help you in setting the future goals of your research.

Johanna Björkroth Vice-Rector Chair of the Steering Group of the Evaluation

Steering Group of the evaluation Steering group, nominated by the Rector of the University, was responsible for the planning of the evaluation and its implementation having altogether 22 meetings between February 2010 and March 2012.

Chair

Vice-Rector, professor Johanna Björkroth Vice-Chair

Professor Marja Airaksinen

Chief Information Specialist, Dr Maria Forsman Professor Arto Mustajoki University Lecturer, Dr Kirsi Pyhältö Director of Strategic Planning and Development, Dr Ossi Tuomi Doctoral candidate, MSocSc Jussi Vauhkonen

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Panel members

CHAIR Professor Lorenz Poellinger Cancer biology, cell and molecular biology Karolinska Institute, Sweden VICE-CHAIR Professor Cornelia van Duijn Genetic epidemiology, Alzheimer’s disease and related disorders Erasmus Medical Centre, the Netherlands Professor Johanna Ivaska Molecular cell biology, cell adhesion, cancer biology University of Turku, VTT Technical Research Centre, Finland Professor Olli Lassila Immunology, medical microbiology University of Turku, Finland Professor Hans-Christian Pape Neuroscience, neurophysiology University of Münster, Germany Professor Thomas Ruzicka Dermatology, allergology Ludwig-Maximilians-Universität (LMU) München, Germany Professor Lars Terenius Experimental alcohol and drug dependence research, mental disorders, preventive medicine Karolinska Institute, Sweden Professor Peter York Physical pharmaceutics, pharmaceutical chemistry, pharmaceutical technology University of Bradford, Great Britain

The panel, independently, evaluated all the submitted material and was responsible for the

feedback of the RC-specific reports. The panel members were asked to confirm whether they had any conflict of interests with the RCs. If this was the case, the panel members disqualified themselves in discussion and report writing.

Added expertise to the evaluation was contributed by two evaluators outside the panels and by

three members from the other panels. External Experts Professor Olli Carpén Pathology, cancer cell metastasis University of Turku Finland Professor Anders Linde Oral biochemi Faculty of Odontology Göteborg University Sweden

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Experts from the Other Panels Professor Jan-Otto Carlsson, from the Panel of Natural Sciences Professor Danny Huylebroek, from the Panel of Biological, Agricultural and Veterinary Sciences Professor Holger Stark, from the Panel of Natural Sciences EVALUATION OFFICE Dr Seppo Saari, Doc., Senior Adviser in Evaluation, was responsible for the entire evaluation, its planning and implementation and acted as an Editor-in-chief of the reports. Dr Eeva Sievi, Doc., Adviser, was responsible for the registration and evaluation material compilations for the panellists. She worked in the evaluation office from August 2010 to July 2011. MSocSc Paula Ranne, Planning Officer, was responsible for organising the panel meetings and all the other practical issues like agreements and fees and editing a part the RC-specific reports. She worked in the evaluation office from March 2011 to January 2012. Mr Antti Moilanen, Project Secretary, was responsible for editing the reports. He worked in the evaluation office from January 2012 to April 2012. TUHAT OFFICE Provision of the publication and other scientific activity data Mrs Aija Kaitera, Project Manager of TUHAT-RIS served the project ex officio providing the evaluation project with the updated information from TUHAT-RIS. The TUHAT office assisted in mapping the publications with CWTS/University of Leiden. MA Liisa Ekebom, Assisting Officer, served in TUHAT-RIS updating the publications for the evaluation. She also assisted the UH/Library analyses. BA Liisa Jäppinen, Assisting Officer, served in TUHAT-RIS updating the publications for the evaluation. HELSINKI UNIVERSITY LIBRARY Provision of the publication analyses Dr Maria Forsman, Chief Information Specialist in the Helsinki University Library, managed with her 10 colleagues the bibliometric analyses in humanities, social sciences and in other fields of sciences where CWTS analyses were not applicable.

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Acronyms and abbreviations applied in the report External competitive funding

AF – Academy of Finland TEKES - Finnish Funding Agency for Technology and Innovation EU - European Union ERC - European Research Council International and national foundations FP7/6 etc. /Framework Programmes/Funding of European Commission

Evaluation marks

Outstanding (5) Excellent (4) Very Good (3) Good (2) Sufficient (1)

Abbreviations of Bibliometric Indicators

P - Number of publications TCS – Total number of citations MCS - Number of citations per publication, excluding self-citations PNC - Percentage of uncited publications MNCS - Field-normalized number of citations per publication MNJS - Field-normalized average journal impact THCP10 - Field-normalized proportion highly cited publications (top 10%) INT_COV - Internal coverage, the average amount of references covered by the WoS WoS – Thomson Reuters Web of Science Databases

Participation category Category 1. The research of the participating community represents the international cutting edge in its field. Category 2. The research of the participating community is of high quality, but the community in its present composition has yet to achieve strong international recognition or a clear break-through. Category 3. The research of the participating community is distinct from mainstream research, and the special features of the research tradition in the field must be considered in the evaluation. Category 4. The research of the participating community represents an innovative opening. Category 5. The research of the participating community has a highly significant societal impact.

Research focus areas of the University of Helsinki

Focus area 1: The basic structure, materials and natural resources of the physical world Focus area 2: The basic structure of life Focus area 3: The changing environment – clean water Focus area 4: The thinking and learning human being Focus area 5: Welfare and safety Focus area 6: Clinical research Focus area 7: Precise reasoning Focus area 8: Language and culture Focus area 9: Social justice Focus area 10: Globalisation and social change

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1 Introduction to the Evaluation

1.1 RC-specific evaluation reports

The participants in the evaluation of research and doctoral training were Researcher Communities (hereafter referred to as the RC). The RC refers to the group of researchers who registered together in the evaluation of their research and doctoral training. Preconditions in forming RCs were stated in the Guidelines for the Participating Researcher Communities. The RCs defined themselves whether their compositions should be considered well-established or new.

It is essential to emphasise that the evaluation combines both meta-evaluation1 and traditional research assessment exercise and its focus is both on the research outcomes and procedures associated with research and doctoral training. The approach to the evaluation is enhancement-led where self-evaluation constituted the main information. The answers to the evaluation questions formed together with the information of publications and other scientific activities an entity that was to be reviewed as a whole.

The present evaluation recognizes and justifies the diversity of research practices and publication traditions. Traditional Research Assessment Exercises do not necessarily value high quality research with low volumes or research distinct from mainstream research. It is challenging to expose the diversity of research to fair comparison. To understand the essence of different research practices and to do justice to their diversity was one of the main challenges of the present evaluation method. Understanding the divergent starting points of the RCs demanded sensitivity from the evaluators.

1.2 Aims and objectives in the evaluation

The aims of the evaluation are as follows:

to improve the level of research and doctoral training at the University of Helsinki and to raise their international profile in accordance with the University’s strategic policies. The improvement of doctoral training should be compared to the University’s policy.2

to enhance the research conducted at the University by taking into account the diversity, originality, multidisciplinary nature, success and field-specificity,

to recognize the conditions and prerequisites under which excellent, original and high-impact research is carried out,

to offer the academic community the opportunity to receive topical and versatile international peer feedback,

to better recognize the University’s research potential. to exploit the University’s TUHAT research information system to enable transparency of

publishing activities and in the production of reliable, comparable data.

1.3 Evaluation method

The evaluation can be considered as an enhancement-led evaluation. Instead of ranking, the main aim is to provide useful information for the enhancement of research and doctoral training of the participating RCs. The comparison should take into account each field of science and acknowledge their special character.

1 The panellists did not read research reports or abstracts but instead, they evaluated answers to the evaluation

questions, tables and compilations of publications, other scientific activities, bibliometrics or comparable analyses. 2

Policies on doctoral degrees and other postgraduate degrees at the University of Helsinki.

http://www.helsinki.fi/tutkinnonuudistus/materiaalit/Policies%20concerning%20doctoral%20degrees%20-%20engl.pdf

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The comparison produced information about the present status and factors that have lead to success. Also challenges in the operations and outcomes were recognized.

The evaluation approach has been designed to recognize better the significance and specific nature of researcher communities and research areas in the multidisciplinary top-level university. Furthermore, one of the aims of the evaluation is to bring to light those evaluation aspects that differ from the prevalent ones. Thus the views of various fields of research can be described and research arising from various starting points understood better. The doctoral training is integrated into the evaluation as a natural component related to research. Operational processes of doctoral training are being examined in the evaluation.

Five stages of the evaluation method were:

1. Registration – Stage 1 2. Self-evaluation – Stage 2 3. TUHAT3 compilations on publications and other scientific activities4 4. External evaluation 5. Public reporting

1.4 Implementation of the external evaluation

Five Evaluation Panels Five evaluation panels consisted of independent, renowned and highly respected experts. The main domains of the panels are:

1. biological, agricultural and veterinary sciences 2. medicine, biomedicine and health sciences 3. natural sciences 4. humanities 5. social sciences

The University invited 10 renowned scientists to act as chairs or vice-chairs of the five panels based on the suggestions of faculties and independent institutes. Besides leading the work of the panel, an additional role of the chairs was to discuss with other panel chairs in order to adopt a broadly similar approach. The panel chairs and vice-chairs had a pre-meeting on 27 May 2011 in Amsterdam.

The panel compositions were nominated by the Rector of the University 27 April 2011. The participating RCs suggested the panel members. The total number of panel members was 50. The reason for a smaller number of panellists as compared to the previous evaluations was the character of the evaluation as a meta-evaluation. The panellists did not read research reports or abstracts but instead, they evaluated answers to the evaluation questions, tables and compilations of publications, other scientific activities, bibliometrics and comparable analyses. The panel meetings were held in Helsinki:

On 11–13 September 2011: (1) biological, agricultural and veterinary sciences, (2) medicine, biomedicine and health sciences and (3) natural sciences.

On 18–20 September 2011: (4) humanities and (5) social sciences.

3 TUHAT (acronym) of Research Information System (RIS) of the University of Helsinki 4 Supervision of thesis, prizes and awards, editorial work and peer reviews, participation in committees, boards and

networks and public appearances.

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1.5 Evaluation material

The main material in the evaluation was the RCs’ self-evaluations that were qualitative in character and allowed the RCs to choose what was important to mention or emphasise and what was left unmentioned.

The present evaluation is exceptional at least in the Finnish context because it is based on both the evaluation documentation (self-evaluation questions, publications and other scientific activities) and the bibliometric reports. All documents were delivered to the panellists for examination.

Traditional bibliometrics can be reasonably done mainly in medicine, biosciences and natural sciences when using the Web of Science database, for example. Bibliometrics, provided by CWTS/The Centre for Science and Technology Studies, University of Leiden, cover only the publications that include WoS identification in the TUHAT-RIS.

Traditional bibliometrics are seldom relevant in humanities and social sciences because the international comparable databases do not store every type of high quality research publications, such as books and monographs and scientific journals in other languages than English. The Helsinki University Library has done analysis to the RCs, if their publications were not well represented in the Web of Science databases (RCs should have at least 50 publications and internal coverage of publications more than 40%) – it meant 58 RCs. The bibliometric material for the evaluation panels was available in June 2011. The RC-specific bibliometric reports are attached at the end of each report.

The panels were provided with the evaluation material and all other necessary background information, such as the basic information about the University of Helsinki and the Finnish higher education system.

Evaluation material

1. Registration documents of the RCs for the background information 2. Self evaluation material – answers to the evaluation questions 3. Publications and other scientific activities based on the TUHAT RIS:

3.1. statistics of publications 3.2. list of publications 3.3. statistics of other scientific activities 3.4. list of other scientific activities

4. Bibliometrics and comparable analyses: 4.1. Analyses of publications based on the verification of TUHAT-RIS publications with the Web

of Science publications (CWTS/University of Leiden) 4.2. Publication statistics analysed by the Helsinki University Library - mainly for humanities and

social sciences 5. University level survey on doctoral training (August 2011) 6. University level analysis on publications 2005–2010 (August 2011) provided by CWTS/University

of Leiden

Background material University of Helsinki - Basic information about the University of the Helsinki - The structure of doctoral training at the University of Helsinki - Previous evaluations of research at the University of Helsinki – links to the reports: 1998 and 2005

The Finnish Universities/Research Institutes - Finnish University system - Evaluation of the Finnish National Innovation System - The State and Quality of Scientific Research in Finland. Publication of the Academy of Finland

9/09.

The evaluation panels were provided also with other relevant material on request before the meetings in Helsinki.

https://wiki.helsinki.fi/download/attachments/70911363/UH_introduction_27052011ES.pdf?version=1&modificationDate=1307360471459

https://wiki.helsinki.fi/download/attachments/70911363/UH_DoctoralTraining.pdf?version=1&modificationDate=1307360051433

http://www.helsinki.fi/arviointi2010-2012/tutkimuksenarviointi_raportti_1999.pdf

http://www.helsinki.fi/arviointi2010-2012/tutkimuksenarviointi_raportti_2005.pdf

https://wiki.helsinki.fi/download/attachments/70911363/HE_Finland_introduction_27052011ES.pdf?version=1&modificationDate=1307359986235

https://wiki.helsinki.fi/download/attachments/70911363/InnoEvaluation_Report2009.pdf?version=1&modificationDate=1307359607255

https://wiki.helsinki.fi/download/attachments/70911363/StageQualityResearch_Summary2009.pdf?version=1&modificationDate=1307359740024

https://wiki.helsinki.fi/download/attachments/70911363/StageQualityResearch_Summary2009.pdf?version=1&modificationDate=1307359740024

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1.6 Evaluation questions and material

The participating RCs answered the following evaluation questions which are presented according to the evaluation form. In addition, TUHAT RIS was used to provide the additional material as explained. For giving the feedback to the RCs, the panellists received the evaluation feedback form constructed in line with the evaluation questions:

1. Focus and quality of the RC’s research

Description of - the RC’s research focus. - the quality of the RC’s research (incl. key research questions and results) - the scientific significance of the RC’s research in the research field(s)

Identification of the ways to strengthen the focus and improve the quality of the RC’s research The additional material: TUHAT compilation of the RC’s publications, analysis of the RC’s publications data (provided by University of Leiden and the Helsinki University Library) A written feedback from the aspects of: scientific quality, scientific significance, societal impact, innovativeness

Strengths Areas of development Other remarks Recommendations

Numeric evaluation: OUTSTANDING (5), EXCELLENT (4), VERY GOOD (3), GOOD (2), SUFFICIENT (1) 2. Practises and quality of doctoral training

Organising of the doctoral training in the RC. Description of the RC’s principles for: - recruitment and selection of doctoral candidates - supervision of doctoral candidates - collaboration with faculties, departments/institutes, and potential graduate schools/doctoral programmes - good practises and quality assurance in doctoral training - assuring of good career perspectives for the doctoral candidates/fresh doctorates

Identification of the RC’s strengths and challenges related to the practises and quality of doctoral training, and the actions planned for their development.

The additional material: TUHAT compilation of the RC’s other scientific activities/supervision of doctoral dissertations A written feedback from the aspects of: processes and good practices related to leadership and management


Numeric evaluation: OUTSTANDING (5), EXCELLENT (4), VERY GOOD (3), GOOD (2), SUFFICIENT (1) 3. The societal impact of research and doctoral training

Description on how the RC interacts with and contributes to the society (collaboration with public, private and/or 3rd sector).

Identification of the ways to strengthen the societal impact of the RC’s research and doctoral training.

The additional material: TUHAT compilation of the RC’s other scientific activities. A written feedback from the aspects of: societal impact, national and international collaboration, innovativeness


Numeric evaluation: OUTSTANDING (5), EXCELLENT (4), VERY GOOD (3), GOOD (2), SUFFICIENT (1)

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4. International and national (incl. intersectoral) research collaboration and researcher mobility Description of

- the RC’s research collaborations and joint doctoral training activities - how the RC has promoted researcher mobility

Identification of the RC’s strengths and challenges related to research collaboration and researcher mobility, and the actions planned for their development.

A written feedback from the aspects of: scientific quality, national and international collaboration Strengths Areas of development Other remarks Recommendations

Numeric evaluation: OUTSTANDING (5), EXCELLENT (4), VERY GOOD (3), GOOD (2), SUFFICIENT (1) 5. Operational conditions

Description of the operational conditions in the RC’s research environment (e.g. research infrastructure, balance between research and teaching duties).

Identification of the RC’s strengths and challenges related to operational conditions, and the actions planned for their development.

A written feedback from the aspects of: processes and good practices related to leadership and management


6. Leadership and management in the researcher community

Description of - the execution and processes of leadership in the RC - how the management-related responsibilities and roles are distributed in the RC - how the leadership- and management-related processes support

- high quality research - collaboration between principal investigators and other researchers in the RC the RC’s research focus - strengthening of the RC’s know-how

Identification of the RC’s strengths and challenges related to leadership and management, and the actions planned for developing the processes

7. External competitive funding of the RC

The RCs were asked to provide information of such external competitive funding, where: - the funding decisions have been made during 1.1.2005-31.12.2010, and - the administrator of the funding is/has been the University of Helsinki

On the e-form the RCs were asked to provide: 1) The relevant funding source(s) from a given list (Academy of Finland/Research Council, TEKES/The Finnish Funding Agency for Technology and Innovation , EU, ERC, foundations, other national funding organisations, other international funding organisations), and 2)The total sum of funding which the organisation in question had decided to allocate to the RCs members during 1.1.2005–31.12.2010.

Competitive funding reported in the text is also to be considered when evaluating this point. A written feedback from the aspects of: scientific quality, scientific significance, societal impact, innovativeness, future significance


8. The RC’s strategic action plan for 2011–2013

RC’s description of their future perspectives in relation to research and doctoral training. A written feedback from the aspects of: scientific quality, scientific significance, societal Impact, processes and good practices related to leadership and management, national and international collaboration, innovativeness, future significance

Strengths Areas of development

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Other remarks Recommendations

9. Evaluation of the category of the RC in the context of entity of the evaluation material (1-8) The RC’s fitness to the chosen participation category A written feedback evaluating the RC’s fitness to the chosen participation category


Numeric evaluation: OUTSTANDING (5), EXCELLENT (4), VERY GOOD (3), GOOD (2), SUFFICIENT (1) 10. Short description of how the RC members contributed the compilation of the stage 2 material Comments on the compilation of evaluation material 11. How the UH’s focus areas are presented in the RC’s research? Comments if applicable 12. RC-specific main recommendations based on the previous questions 1–11 13. RC-specific conclusions

1.7 Evaluation criteria

The panellists were expected to give evaluative and analytical feedback to each evaluation question according to their aspects in order to describe and justify the quality of the submitted material. In addition, the evaluation feedback was asked to be pointed out the level of the performance according to the following classifications:

outstanding (5) excellent (4) very good (3) good (2) sufficient (1)

Evaluation according to the criteria was to be made with thorough consideration of the entire

evaluation material of the RC in question. Finally, in questions 1-4 and 9, the panellists were expected to classify their written feedback into one of the provided levels (the levels included respective descriptions, ‘criteria’). Some panels used decimals in marks. The descriptive level was interpreted according to the integers and not rounding up the decimals by the editors.

Description of criteria levels Question 1 – FOCUS AND QUALITY OF THE RC’S RESEARCH Classification: Criteria (level of procedures and results)

Outstanding quality of procedures and results (5) Outstandingly strong research, also from international perspective. Attracts great international interest with a wide impact, including publications in leading journals and/or monographs published by leading international publishing houses. The research has world leading qualities. The research focus, key research questions scientific significance, societal impact and innovativeness are of outstanding quality.

In cases where the research is of a national character and, in the judgement of the evaluators, should remain so, the concepts of ”international attention” or ”international impact” etc. in the grading criteria above may be replaced by ”international comparability”.

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Operations and procedures are of outstanding quality, transparent and shared in the community. The improvement of research and other efforts are documented and operations and practices are in alignment with the documentation. The ambition to develop the community together is of outstanding quality.

Excellent quality of procedures and results (4)

Research of excellent quality. Typically published with great impact, also internationally. Without doubt, the research has a leading position in its field in Finland.

Operations and procedures are of excellent quality, transparent and shared in the community. The improvement of research and other efforts are documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of excellent quality.

Very good quality of procedures and results (3)

The research is of such very good quality that it attracts wide national and international attention.

Operations and procedures are of very good quality, transparent and shared in the community. The improvement of research and other efforts are documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of very good quality.

Good quality of procedures and results (2)

Good research attracting mainly national attention but possessing international potential, extraordinarily high relevance may motivate good research.

Operations and procedures are of good quality, shared occasionally in the community. The improvement of research and other efforts are occasionally documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of good quality.

Sufficient quality of procedures and results (1)

In some cases the research is insufficient and reports do not gain wide circulation or do not have national or international attention. Research activities should be revised.

Operations and procedures are of sufficient quality, shared occasionally in the community. The improvement of research and other efforts are occasionally documented and operations and practices are to some extent in alignment with the documentation. The ambition to develop the community together is of sufficient quality.

Question 2 – DOCTORAL TRAINING Question 3 – SOCIETAL IMPACT Question 4 – COLLABORATION

Classification: Criteria (level of procedures and results)

Outstanding quality of procedures and results (5)

Procedures are of outstanding quality, transparent and shared in the community. The practices and quality of doctoral training/societal impact/international and national collaboration/leadership and management are documented and operations and practices are in alignment with the documentation. The ambition to develop the community together is of outstanding quality. The procedures and results are regularly evaluated and the feedback has an effect on the planning.

Excellent quality of procedures and results (4)

Procedures are of excellent quality, transparent and shared in the community. The practices and quality of doctoral training/societal impact/international and national collaboration/leadership and management are documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of excellent quality. The procedures and outcomes are evaluated and the feedback has an effect on the planning.

Very good quality of procedures and results (3)

Procedures are of very good quality, transparent and shared in the community. The practices and quality of doctoral training/societal impact/international and national collaboration/leadership and

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management are documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of very good quality.

Good quality of procedures and results (2)

Procedures are of good quality, shared occasionally in the community. The practices and quality of doctoral training/societal impact/international and national collaboration/leadership and management are documented and operations and practices are to large extent in alignment with the documentation. The ambition to develop the community together is of good quality.

Sufficient quality of procedures and results (1)

Procedures are of sufficient quality, transparent and shared in the community. The practices and quality of doctoral training/societal impact/international and national collaboration/leadership and management are occasionally documented and operations and practices are to some extent in alignment with the documentation. The ambition to develop the community together is of sufficient quality.

Question 9 – CATEGORY

Participation category – fitness for the category chosen

The choice and justification for the chosen category below should be reflected in the RC’s responses to the evaluation questions 1–8.

1. The research of the participating community represents the international cutting edge in its field. 2. The research of the participating community is of high quality, but the community in its present

composition has yet to achieve strong international recognition or a clear break-through. 3. The research of the participating community is distinct from mainstream research, and the special

features of the research tradition in the field must be considered in the evaluation. The research is of high quality and has great significance and impact in its field. However, the generally used research evaluation methods do not necessarily shed sufficient light on the merits of the research.

4. The research of the participating community represents an innovative opening. A new opening can be an innovative combination of research fields, or it can be proven to have a special social, national or international demand or other significance. Even if the researcher community in its present composition has yet to obtain proof of international success, its members can produce convincing evidence of the high level of their previous research.

5. The research of the participating community has a highly significant societal impact. The participating researcher community is able to justify the high social significance of its research. The research may relate to national legislation, media visibility or participation in social debate, or other activities promoting social development and human welfare. In addition to having societal impact, the research must be of a high standard.

An example of outstanding fitness for category choice (5) 5

The RC’s representation and argumentation for the chosen category were convincing. The RC recognized its real capacity and apparent outcomes in a wider context to the research communities. The specific character of the RC was well-recognized and well stated in the responses. The RC fitted optimally for the category.

Outstanding (5) Excellent (4) Very good (3) Good (2) Sufficient (1)

The above-mentioned definition of outstanding was only an example in order to assist the panellists in the positioning of the classification. There was no exact definition for the category fitness.

5 The panels discussed the category fitness and made the final conclusions of the interpretation of it.

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1.8 Timetable of the evaluation

The main timetable of the evaluation: 1. Registration November 2010 2. Submission of self-evaluation materials January–February 2011 3. External peer review May–September 2011 4. Published reports March–April 2012

- University level public report - RC specific reports

The entire evaluation was implemented during the university’s strategy period 2010–2012. The preliminary results were available for the planning of the following strategy period in late autumn 2011. The evaluation reports will be published in March/April 2012. More detailed time schedule is published in the University report.

1.9 Evaluation feedback – consensus of the entire panel

The panellists evaluated all the RC-specific material before the meetings in Helsinki and mailed the draft reports to the evaluation office. The latest interim versions were on-line available to all the panellists on the Wiki-sites. In September 2011, in Helsinki the panels discussed the material, revised the first draft reports and decided the final numeric evaluation. After the meetings in Helsinki, the panels continued working and finalised the reports before the end of November 2011. The final RC-specific reports are the consensus of the entire panel.

The evaluation reports were written by the panels independently. During the editing process, the evaluation office requested some clarifications from the panels when necessary. The tone and style in the reports were not harmonized in the editing process. All the reports follow the original texts written by the panels as far as it was possible.

The original evaluation material of the RCs, provided for the panellists is attached at the end of the report. It is essential to notice that the exported lists of publications and other scientific activities depend how the data was stored in the TUHAT-RIS by the RCs.

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2 Evaluation feedback

2.1 Focus and quality of the RC’s research

Description of the RC’s research focus the quality of the RC’s research (incl. key research questions and results) the scientific significance of the RC’s research in the research field(s)

Identification of the ways to strengthen the focus and improve the quality of the RC’s research ASPECTS: Scientific quality, scientific significance, societal impact, innovativeness The RC covers a broad area of research in human disease genetics including studies of the Finnish Disease Heritage with several monogenic disorders unique to Finland. General complex traits have been the major focus over the past five years. The RC has participated actively in the wave of genome wide associations (GWA). Without a doubt, the RC had many successes in the past decade. A major strength of the group has been the implementation of new technology into clinical and epidemiological research. As to the research area of focus, there is a wide interest. This is strength in terms of participating in many genetic studies and being part of many high profile papers. However, the other side of the coin is that the group is not always recognized as leading in a field of subject matter. A question to the RC is whether it would be important to define a distinct set of research lines of interest targeting specific disorders (lipids, metabolic syndrome?) or risk factors (smoking?) that will be flagships for the group and will give the group high profile/leadership. From the Leiden literature-analyses, metabolism and endocrinology have yielded the largest volume of papers.

The output of the group has been extremely high including over almost a 1000 articles many in the highest-impact journals across biomedical and clinical science in 2005-2010 including at least 12 Nature papers, 44 Nature Genetics papers, 3 in Science, 9 together in NEJM and Lancet, 15 in PlosGenet and 24 in AJHG. The average H-index of the group is 31.6. The RC is extremely active in various international consortia.

Numeric evaluation: 5 (Outstanding)

2.2 Practises and quality of doctoral training

Organising of the doctoral training in the RC. Description of the RC’s principles for: recruitment and selection of doctoral candidates supervision of doctoral candidates collaboration with faculties, departments/institutes, and potential graduate schools/doctoral

programmes good practises and quality assurance in doctoral training assuring of good career perspectives for the doctoral candidates/fresh doctorates

Identification of the RC’s strengths and challenges related to the practises and quality of doctoral training, and the actions planned for their development.

Additional material: TUHAT compilation of the RC’s other scientific activities/supervision of doctoral dissertations

ASPECTS: Processes and good practices related to leadership and management

Currently in the RC, there are 34 PhD students enrolled. There are over 100 Doctoral theses. Seventeen RC members have acted as supervisors during 2005-2010. Group leaders have all been involved in several graduate schools. The courses and tutoring of graduate schools in the University of Helsinki have provided the skeleton for the training of the researchers within the RC. Each graduate student has a thesis

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committee with scientists outside the RC. One of the strength of the RC is that it integrates basic science (molecular genetics) with clinical science (clinical genetics) and epidemiology (particular genomic epidemiology and biostatistics). There is a large market for the PhD’s for jobs in and outside Finland. The RC has an international perspective.


2.3 The societal impact of research and doctoral training

Description on how the RC interacts with and contributes to the society (collaboration with public, private and/or 3rd sector).

Identification of the ways to strengthen the societal impact of the RC’s research and doctoral training. Additional material: TUHAT compilation of the RC’s other scientific activities.

ASPECTS: Societal impact, national and international collaboration, innovativeness The group has had a high visibility in Europe and the rest of the world, which was mostly driven by the late Leena Peltonen. The network of the group is large and spans major institutes in Europe (Welcome, Karolinska) and the US (Broad). In the short term, the links will be maintained. The long term perspective is less clear at this point, and the RC should outline a strategy to maintain the high level for the future. The major societal/public impact has been in the field of the Finnish diseases. These findings were translated successfully into public health and clinical practice. The translation of findings on complex disease or behavorial factors (smoking) to the community will be a more difficult challenge.


2.4 International and national (incl. intersectoral) research collaboration and researcher mobility

Description of the RC’s research collaborations and joint doctoral training activities how the RC has promoted researcher mobility

Identification of the RC’s strengths and challenges related to research collaboration and researcher mobility, and the actions planned for their development.

ASPECTS: Scientific quality, national and international collaboration One of the hallmarks of this RC is its strong partnership with major international research centers. Members of the RC have faculty positions in the Karolinska Institute in Sweden, the Broad Institute in the United States and the Sanger Institute in the United Kingdom. These partnerships facilitate key roles in large international pioneering projects. Such current projects include the 1000genomes project and the UK10K project (www.uk10k.org). The mobility of the RC is high at all levels (senior, junior, postdoc).


2.5 Operational conditions


Identification of the RC’s strengths and challenges related to operational conditions, and the actions planned for their development.

ASPECTS: Processes and good practices related to leadership and management

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The infrastructure is excellent both for complex diseases and typical Finnish diseases. The strength of the RC is at present the combination of large epidemiological studies and clinical series with technology. Their new target is next generation sequencing which is ongoing now. The RC benefits from an up-to-date technology center such as FIMM. For large scale computations and statistics also the Centre for Scientific Computing is highly relevant. There is not a strong plan worked out for future plans beyond high-throughput sequencing.

2.6 Leadership and management in the researcher community

Description of the execution and processes of leadership in the RC how the management-related responsibilities and roles are distributed in the RC how the leadership- and management-related processes support

high quality research collaboration between principal investigators and other researchers in the RC the RC’s research focus strengthening of the RC’s know-how

Identification of the RC’s strengths and challenges related to leadership and management, and the actions planned for developing the processes

ASPECTS: Processes and good practices related to leadership and management The management structure seems to be flat and orientated towards PI’s, institutes (e.g. FIMM) and collaborations. The collaboration among principal investigators is excellent. This requires some elucidation. It is not clear to the panel how the tragic loss of Leena Peltonen will be compensated in terms of leadership in genetics. It will be difficult if not impossible to replace, but in the coming years, it will be important to develop a strategy to maintain the quality of research and maintain the know-how. A key issue to consider is whether there is a need to define a research focus that will give the group a recognizable profile in which they are recognized as experts in Europe and the world.

2.7 External competitive funding of the RC

• The RCs were asked to provide information of such external competitive funding, where: • the funding decisions have been made during 1.1.2005–31.12.2010, and • the administrator of the funding is/has been the University of Helsinki

• On the e-form the RCs were asked to provide: 1) The relevant funding source(s) from a given list (Academy of Finland/Research Council, TEKES/The Finnish Funding Agency for Technology and Innovation, EU, ERC, foundations, other national funding organisations, other international funding organizations), and 2) The total sum of funding which the organisation in question had decided to allocate to the RCs members during 1.1.2005–31.12.2010.

Competitive funding reported in the text is also to be considered when evaluating this point. ASPECTS: Scientific quality, scientific significance, societal impact, innovativeness and future significance There is a high degree of competitive funding. Funding includes the Academy of Finland, TEKES, ERC, Solhberg Foundation, Finnish Cultural Foundation, Gastroenterology foundation, Pesatu, Nurmi Foundation, Finnish Foundation for Cardiovascular Research, Wallenberg Foundation, European Science Foundation, Novo Nordisk Fonden, KELA, Pfizer Foundation, Sigrid Juselius Foundation, NIH, Karolinska institutet, AKC Canine Foundation, Swedish Research Council, NordForsk, CIMO, Uppsala University, Indiana University and EVO, HUSLAB, Biocentrum Helsinki, University of Helsinki Funds, University of Helsinki, National Institute for Health and Welfare (THL), Ministry of Education and Culture, Helsinki

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Graduate Program in Biotechnology and Molecular Biology GPBM, HBGS Graduate School, The Finnish Medical Society Duodecim.

2.8 The RC’s strategic action plan for 2011–2013

• RC’s description of their future perspectives in relation to research and doctoral training. ASPECTS: Scientific quality, scientific significance, societal Impact, processes and good practices related to leadership and management, national and international collaboration, innovativeness, future significance Basically, the RC proposes to continue the work on complex diseases, moving from GWAS to high throughput sequencing. It is the obvious step, but there is little detail. It is not clear where they will put the cards: which outcomes, disease or behavior factors, which populations, and who will be responsible for what. There is little view in the document on priorities and goals for the group or for the individual members.

2.9 Evaluation of the category of the RC in the context of entity of the evaluation material (1-8)

The RC’s fitness to the chosen participation category. Category 1. The research of the participating community represents the international cutting edge in its field. There is no doubt that achievements, publications and infrastructure justify the category outstanding.


2.10 Short description of how the RC members contributed the compilation of the stage 2 material

—

2.11 How the UH’s focus areas are presented in the RC’s research

Focus area 2: The basic structure of life —

2.12 RC-specific main recommendations

The major request of the panel is develop more structure: both in management as well key topics to address in the near future. This is particular relevant now that one of the key leaders deceased sadly.

2.13 RC-specific conclusions

The RC is without a doubt competitive in its category 1. The infrastructure developed over the years gives the group an extremely good head start. In the coming year, there is a need to develop a strategical plan

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for future research, outlining areas of focus. Another important task will be the development of a research management structure that will guaranty competitiveness.

2.14 Preliminary findings in the Panel-specific feedback

See questions above. The RC covers a broad area of research in human disease genetics including studies of the Finnish

Disease Heritage with several monogenic disorders unique to Finland. General complex traits have been the major focus over the past five years. The RC has participated actively in the wave of genome wide associations (GWA). Without doubt, the RC had many successes the past decade. A major strength of the group has been the implementation of new technology into clinical and epidemiological research. As to the research area of focus, there is a wide interest. This is strength in terms of participating in many genetic studies and being part of many high profile papers. However, the other side of the coin is that the group is not always recognized as leading in a field of subject matter. A question to the RC is whether it would be important to define a distinct set of research lines of interest targeting specific disorders (lipids, metabolic syndrome?) or risk factors (smoking?) that will be flagships for the group and will give the group high profile/leadership. From the Leiden literature-analyses metabolism and endocrinology have yielded the largest volume of papers.

The output of the group has been extremely high including over almost a 1000 articles many in the highest-impact journals across biomedical and clinical science in 2005-2010 including at least 12 Nature papers, 44 Nature Genetics papers, 3 in Science, 9 together in NEJM and Lancet, 15 in PlosGenet and 24 in AJHG. The average H-index of the group is 31.6. The RC is extremely active in various international consortia. There are over 100 Doctoral theses. RC members have acted as supervisors during 2005-2010. Group leaders have all been involved in several graduate schools. The courses and tutoring of graduate schools in the University of Helsinki have provided the skeleton for the training of the researchers within the RC. Each graduate student has a thesis committee with scientists outside the RC. One of the strength of the RC is that it integrates basic science (molecular genetics) with clinical science (clinical genetics) and epidemiology (particular genomic epidemiology and biostatistics). There is a large market for the PhDs for jobs in and outside Finland. The RC has an international perspective.

The group has had a high visibility in Europe and the world, which was mostly driven by the late Leena Peltonen. The network of the group is large spans major institutes in the Europe (Welcome, Karolinska) and the US (Broad). In the short term, the links will be maintained. The long term perspective is less clear at this point in the absence of Leena Peltonen, asking the RC to outline a strategy to maintain the high level for the future. The major societal/public impact has been in the field of the Finnish diseases. These findings were translated successfully into public health and clinical practice. The translation of findings on complex disease or behavorial factors (smoking) to the community will be a more difficult challenge. Collaboration with private interests is primarily technology driven.

One of the hallmarks of this RC is its strong partnership with major international research centers. Members of the RC have faculty positions in the Karolinska Institute in Sweden, the Broad Institute in the United States and the Sanger Institute in the United Kingdom. These partnerships facilitate key roles in large international pioneering projects. Such current projects include the 1000genomes project and the UK10K project (www.uk10k.org). The mobility of the RC is high at all levels (senior, junior, postdoc). The infrastructure is excellent both for complex diseases and typical Finnish diseases. The strength of the RC is at present the combination of large epidemiological studies and clinical series with technology. Their new target is next generation sequencing which is ongoing now. The RC benefits from an up to date technology center such as FIMM. For large scale computations and statistics also the Centre for Scientific Computing is highly relevant. There is not a strong plan worked out for future plans beyond high-throughput sequencing.

The collaboration among principal investigators is excellent. The management structure seems to be flat and orientated towards PI’s and institutes (e.g. FIMM) and collaborations. This requires some elucidation. It is not clear to the committee how the tragic loss of Leena Peltonen will be compensated in terms of leadership in genetics. It will be difficult if not impossible to replace but in the coming years it will

20

be important to develop a strategy to maintain the quality of research and maintain the know-how. A key issue to consider is whether there is a need to define a research focus that will give the group a recognizable profile in which they are recognized as experts in Europe and the world. Up until now, there is excelling external funding.

2.15 Preliminary findings in the University-level evaluation

The RC covers a broad area of research in human disease genetics including studies of the Finnish Disease Heritage with several monogenic disorders unique to Finland. General complex traits have been the major focus over the past five years. The RC has participated actively in the wave of genome wide associations (GWA). Without a doubt, the RC had many successes the past decade. The output of the group has been extremely high including over almost a 1000 articles many in the highest-impact journals across biomedical and clinical science in 2005-2010 including at least 12 Nature papers, 44 Nature Genetics papers, 3 in Science, 9 together in NEJM and Lancet, 15 in PlosGenet and 24 in AJHG. The average H-index of the group is 31.6. The RC is extremely active in various international consortia. A major strength of the group has been the implementation of new technology into clinical and epidemiological research. As to the research area focus, there is a wide interest. This is strength in terms of participating in many genetic studies and being part of many high profile papers. However, the other side of the coin is that the group is not always recognized as leading in a field of subject matter. A question to the RC is whether it would be important to define a distinct set of research lines of interest targeting specific disorder that will be flagships for the group and will give the group high profile/leadership.

One of the strength of the RC is that it integrates basic science (molecular genetics) with clinical science (clinical genetics) and epidemiology (particular genomic epidemiology and biostatistics). There is a large market for the PhDs for jobs in and outside Finland. The RC has an international perspective. The group has had a high visibility in Europe and the world, which was mostly driven by the late Leena Peltonen. The network of the group is large spans major institutes in the Europe (Welcome, Karolinska) and the US (Broad). In the short term, the links will be maintained. One of the hallmarks of this RC is its strong partnership with major international research centers. Members of the RC have faculty positions in the Karolinska Institute in Sweden, the Broad Institute in the United States and the Sanger Institute in the United Kingdom. These partnerships facilitate key roles in large international pioneering projects. Such current projects include the 1000genomes project and the UK10K project (www.uk10k.org). The mobility of the RC is high at all levels (senior, junior, postdoc). The infrastructure is excellent both for complex diseases and typical Finnish diseases. The long term perspective is less clear at this point in the absence of Leena Peltonen, asking the RC to outline a strategy to maintain the high level for the future. The major societal/public impact has been in the field of the Finnish diseases. These findings were translated successfully into public health and clinical practice. The translation of findings on complex disease or behavorial factors (smoking) to the community will be a more difficult challenge. Collaboration with the private interests is primarily technology driven.

The strength of the RC is at present the combination of large epidemiological studies and clinical series with technology. The collaboration among principal investigators is excellent. The management structure seems to flat and orientated towards PIs and institutes. This raises question for the future. It is not clear to the committee how the tragic loss of Leena Peltonen will be compensated in terms of leadership in genetics. In the coming years it will be important to develop a strategy to maintain the quality of research and maintain the know-how. A key issue to consider is whether there is a need to define a research focus that will give the group a recognizable profile in which they are recognized as experts in Europe and the world. Up until now, there is excellent external funding.

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3 Appendices

A. Original evaluation material a. Registration material – Stage 1 b. Answers to evaluation questions – Stage 2 c. List of publications d. List of other scientific activities

B. Bibliometric analyses a. Analysis provided by CWTS/University of Leiden b. Analysis provided by Helsinki University Library (66 RCs)

International evaluation of research and doctoral training at the University of Helsinki 2005-2010

RC-SPECIFIC MATERIAL FOR THE PEER REVIEW

NAME OF THE RESEARCHER COMMUNITY: Complex Disease Genomics Group (CompDisGen)

LEADER OF THE RESEARCHER COMMUNITY: Professor Jaakko Kaprio, Department of Public Health, University of Helsinki; Institute for Molecular Medicine Finland (FIMM)

RC-SPECIFIC MATERIAL FOR THE PEER REVIEW:

Material submitted by the RC at stages 1 and 2 of the evaluation - STAGE 1 material: RC’s registration form (incl. list of RC participants in an excel table) - STAGE 2 material: RC’s answers to evaluation questions

TUHAT compilations of the RC members’ publications 1.1.2005-31.12.2010

TUHAT compilations of the RC members’ other scientific activities 1.1.2005-31.12.2010

Web of Science(WoS)-based bibliometrics of the RC’s publications data 1.1.2005-31.12.2010 (analysis carried out by CWTS, Leiden University)

NB! Since Web of Science(WoS)-based bibliometrics does not provide representative results for most RCs representing humanities, social sciences and computer sciences, the publications of these RCs will be analyzed by the UH Library (results available by the end of June, 2011)

1

INTERNATIONAL EVALUATION OF RESEARCH AND DOCTORAL TRAINING AT THE UNIVERSITY OF HELSINKI

RC-SPECIFIC STAGE 1 MATERIAL (registration form)

Name: Kaprio, Jaakko

E-mail:

Phone: +358 9 191 27 595

Affiliation: Professor of Genetic Epidemiology

Street address: Mannerheimintie 172

Name of the participating RC (max. 30 characters): Complex Disease Genomics Group

Acronym for the participating RC (max. 10 characters): CompDisGen

Description of the operational basis in 2005-2010 (eg. research collaboration, joint doctoral training activities) on which the RC was formed (MAX. 2200 characters with spaces): The RC integrates the strengths of Finnish molecular genetics, clinical science, genomic epidemiology and biostatistics. The PIs of the RC include scientists with a worldwide-recognized expertise and a strong track record in respective fields. Many of the PIs belong to the Academy of Finland Center of Excellence in Complex Disease Genetics. They have also made a significant contribution to doctoral training at the University. The RC has participated actively on the wave of genome wide associations (GWA), which has been a success story in the identification of common variants associated with complex traits over the past 5 years. However, typically these variants explain only a small fraction of the genetic variance of the trait. The missing genetic variance may be accounted for by 1) common variants where the effect size is very small, odds ratios less than 1.1, 2) a large number of relatively rare variants that are responsible for a significant proportion of unidentified genetic predisposition, and 3) gene-environmental interactions. The variants identified in GWA have stimulated research to understand their impact on cellular, individual and population level. Well characterized, large epidemiological Finnish collections provide a special opportunity to study the contribution of individual variants, combination of variants and their cross talk with environmental and life style factors on disease susceptibility at different stages of life. Our RC encompasses a wide range of studies on many complex diseases for which the genetic architecture varies. Our RC has also developed unique animal models such as mice and dogs to further help to identify and model the molecular background and pathogenesis of human inherited diseases. Through active collaborations between the partners in the RC, and with scientists and labs outside the RC at the University of Helsinki as well as with other research groups nationally and internationally, the RC has contributed strongly to new knowledge of the genetic basis of common diseases and their risk factors.

Main scientific field of the RC’s research: medicine, biomedicine and healt sciences

RC's scientific subfield 1: Genetics and Heredity

1 RESPONSIBLE PERSON

2 DESCRIPTION OF THE PARTICIPATING RESEARCHER COMMUNITY (RC)

3 SCIENTIFIC FIELDS OF THE RC

2



RC's scientific subfield 2: Biochemistry and Molecular Biology

RC's scientific subfield 3: Veterinary Sciences

RC's scientific subfield 4: --Select--

Other, if not in the list: Comparative Genetics, Epidemiology, Translational Medicine

Participation category: 1. Research of the participating community represents the international cutting edge in its field

Justification for the selected participation category (MAX. 2200 characters with spaces): Our RC has decided to become evaluated in the Category 1. The established RC includes many active and internationally well-recognized and established investigators in the field of human genetics. Our RC has generated tens of new doctorate students and postdocs and has published over 800 articles many in the highest-impact journals across biomedical and clinical science in 2005-2010 including at least 12 Nature papers, 44 Nature Genetics papers, 3 in Science, 9 together in NEJM and Lancet, 15 in PlosGenet and 24 in AJHG. The PIs are highly cited, very productive and successful in generating external grants. Through active collaborations between the partners in the RC, and with scientists and labs outside the RC at the University of Helsinki as well as with other research groups nationally and internationally, the RC has contributed strongly to new knowledge of the genetic basis of common diseases and their risk factors. Our outstanding track record in terms of publications and external grants justifies the Evaluation category 1.

Public description of the RC's research and doctoral training (MAX. 2200 characters with spaces): Our RC

represents a long and well-established tradition in human disease genetics including studies of the Finnish Disease Heritage with several monogenic disorders unique to Finland. Subsequent development of human genetics towards complex traits has been the major focus over the past five years. The RC has participated actively on the wave of genome wide associations (GWA), which has been a success story in the identification of common variants associated with complex traits. The variants identified in GWA have stimulated research to understand their impact on cellular, individual and population level. Well characterized, large epidemiological Finnish collections provide a special opportunity to study the contribution of individual variants, combination of variants and their cross talk with environmental and life style factors on disease susceptibility at different stages of life. Our RC encompasses a wide range of studies on many complex diseases for which the genetic architecture varies. To further study and dissect the molecular mechanisms of various diseases we have also developed several unique animal models of human complex disease including canine genetic system. Through active collaborations between the partners in the RC, and with scientists and labs outside the RC at the University of Helsinki as well as with other research groups nationally and internationally, the RC has contributed strongly to new knowledge of the genetic basis of common diseases and their risk factors. The RC groups have extensive experience in training of graduate students and postdoctoral fellows and the group leaders have all been involved several graduate schools. The courses and tutoring of graduate schools in the University of Helsinki have provided the skeleton for the training of the researchers within the RC. Each graduate student has thesis committee with scientists outside the RC. The RC has trained numerous scientists with 54 PhDs defended at the

4 RC'S PARTICIPATION CATEGORY

5 DESCRIPTION OF THE RC'S RESEARCH AND DOCTORAL TRAINING

3



University of Helsinki in 2005-2010 and currently there are 34 PhD students enrolled. Seventeen RC members have acted as supervisors during 2005-2010.

Significance of the RC's research and doctoral training for the University of Helsinki (MAX. 2200 characters with spaces): The RC comprises the best expertise overall in complex disease genetics at the University of Helsinki and Finland and is well-recognized worldwide. The research area in human disease genetics is also highly-recognized among the general public according to the Finnish Science Barometer 2010. The RC contains PIs are that are internationally prominent scientists including memberships for example in the Nobel committee. ERCStG was awarded to Hannes Lohi in 2010. RC’s expertise spans technologies, epidemiology & sample collection, biobanking, analyses and translational activities including animal models and preclinical trials. The RC plays a key role in the development and maintenance of infrastructure as core facilities needed for the state-of-art genetic and genomic research. An important element is the FIMM Technology Centre, which is a local, national and international infrastructure and service facility developing new technologies and serving the user community with state of the art technologies. FIMM Technology Centre has excellent research facilities, including high- and medium throughput systems for genotyping sequencing ), transcript profiling , high-throughput RNAi screening and translational technologies. To serve the needs of computation and data management FIMM Technology Centre has tripled its computational processing power and continues to increase its capacity of the storage array network (SAN). . FIMM Technology Centre maintains over hundred physical and virtual servers used for hosting bioinformatics databases and other applications. The Centre utilizes the latest IT tools such as virtualization and scale-out storage technologies to provide a robust and scalable platform for doing data intensive science. Collaboration with Centre for Scientific Computing (www.CSC.fi) enables usage of CSC facilities when very high capabilities are needed. Based on the development of this outstanding expertise, infrastructure and reputation the RC has been eminently successful in external grant competitions and in attracting gifted students for PhD studies and postdoctoral work.

Keywords: gene, mutation, genetics, genomics, linkage, association,

disease, complex trait, pedigree, human, dog, mouse, cardiovascular disease, autoimmune disease, migraine, epilepsy, psychiatric disease, asthma, dyslexia, hypertension, obesity, metabolic disorder, substance

abuse disorder, copy number variation, mapping, GWAS, SNP, polymorphic, linear regression, comparative genetics, animal model, bioinformatics, systems biology, meta-analysis

Justified estimate of the quality of the RC's research and doctoral training at national and international level during 2005-2010 (MAX. 2200 characters with spaces): Our research spans national and international collaborations. At the University of Helsinki, we work across faculties and research institutes. The most important ones are FIMM and the Research Programs Unit of the Faculty of Medicine. National collaborations are also close with the National Institute for Health and Welfare, but also with other state research institutes, Finnish Universities and Biocenter Finland. A very productive relationship with the Wellcome Trust Sanger Institute has existed. Many PIs have also international affiliations. One of the largest International studies closely integrated with the RC is the ENGAGE integrated project of the FP7 program of EU for which UH is the lead coordinator. This 12 M€ project focuses on pooling datasets across

6 QUALITY OF RC'S RESEARCH AND DOCTORAL TRAINING

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over 120 000 GWA studies in traits related to metabolic syndrome, cardiovascular diseases and obesity and characterization of joint actions between genetic profiles and life style. A multisite NIDA/NCI funding aims to identify functional genes for nicotine dependence on chromosome 22. Newly funded or impending EU FP7 projects that we are involved in include TORNADO (gut microbe – dietary interactions in obesity and metabolic diseases); GENODISC (structural and functional genomics of intervertebral disc degeneration); BioSHARE (Biobank Standardization and Harmonization); SYNSYS (A European Exert Network in Building Synapse) in addition to continuing our collaborations in existing EU projects such as EUROHEAD, DIOGENES, EUROCLOT, GEHA, EPICURE, LUPA (dog genomics) and SGENE. Because of the role of RC investigators in Wellcome Trust Sanger Institute, Broad Institute (Palotie, Peltonen) and Karolinska Institute (Kere) RC investigators participate often in a leading role in large international collaborative efforts. This guarantees excellent access to data produced by projects like Hapmap3, 1000 Genomes and EUVADIS (aiming to sequence 1000 individuals with early disease phenotype in cardiovascular and metabolic diseases). These collaborations also harmonize operations of CoE with critical Nordic operators in biobanking and genetic and disease databases (Nordic Center of Excellence, www.ncoedg.org).

Comments on how the RC's scientific productivity and doctoral training should be evaluated (MAX. 2200 characters with spaces): Our RC members are basic scientists. We can be evaluated on the basis of our publication record, citations, external grants and significant recognitions in addition to our track record in research training. We can be compared to other groups on a global level, and all research groups in the RC have active networks of collaborations with individual centres in Finland and internationally. Research groups with similar programs and research questions in complex disease genetics include Helmholtz Centre in Munich, DeCode Genetics in Reykjavik, The Broad Institute, Boston, MA, Karolinska Institute, and Framingham Study in Boston, US. Our output has been extremely productive and at the highest scientific level. Many of our PhD students have pursued an active scientific career in post-doc positions in Finland and internationally, with continuing scientific productivity. We publish cutting-edge research in the best possible journals.

LIST OF RC MEMBERS

NAME OF THE RESEARCHER COMMUNITY: Complex Disease Genomics GroupRC-LEADER J. KaprioCATEGORY 1

Last name First name

PI-status (TUHAT-check,

lista 29.11.)Title of research and teaching personnel Affiliation

1 Kaprio Jaakko x Research Director, ProfessorDepartment of Public Health, University of Helsinki and Institute for Molecular Medicine Finland FIMM

2 Bogl Leonie-Helen Doctoral candidate Department of Public Health, University of Helsinki3 Broms Ulla Doctoral candidate -> Postdoctoral researcherDepartment of Public Health, University of Helsinki4 Hukkinen Maria Doctoral candidate Department of Public Health, University of Helsinki5 Keski-Rahkonen Anna x Postdoctoral researcher Department of Public Health, University of Helsinki6 Korhonen Tellervo x Senior researcher Department of Public Health, University of Helsinki7 Lajunen Hanna-Reetta Doctoral candidate -> Postdoctoral researcherDepartment of Public Health, University of Helsinki8 Latvala Antti Doctoral candidate Department of Public Health, University of Helsinki9 Loukola Anu University researcher Department of Public Health, University of Helsinki

10 Mustelin Linda Doctoral candidate Department of Public Health, University of Helsinki11 Ollikainen Miina Postdoctoral researcher Department of Public Health, University of Helsinki12 Ortega-Alonso Alfredo Postdoctoral researcher Department of Public Health, University of Helsinki

13 Pietiläinen Kirsi x University researcherDepartment of Public Health, University of Helsinki and Institute for Molecular Medicine Finland FIMM

14 Raevuori Anu Doctoral candidate -> Postdoctoral researcherDepartment of Public Health, University of Helsinki15 Saarni Suoma Doctoral candidate -> Postdoctoral researcherDepartment of Public Health, University of Helsinki

16 Sihvola Elina Doctoral candidate -> Postdoctoral researcherDepartment of Public Health, University of Helsinki and Department of Psychiatry

17 Vuokko Kaisu Doctoral candidate -> Postdoctoral researcherDepartment of Public Health, University of Helsinki18 Kere Juha x Research Director, Professor Department of Medical Genetics, University of Helsinki19 Elomaa Outi Senior researcher Department of Medical Genetics, University of Helsinki20 Hannula-Jouppi Katariina x University researcher Department of Medical Genetics, University of Helsinki21 Järvinen Tiina Doctoral candidate Department of Medical Genetics, University of Helsinki22 Kaminen-Ahola Nina Doctoral candidate Department of Medical Genetics, University of Helsinki23 Lappalainen Tuuli Doctoral candidate Department of Medical Genetics, University of Helsinki24 Massinen Satu Doctoral candidate Department of Medical Genetics, University of Helsinki25 Pulkkinen Ville Doctoral candidate -> Postdoctoral researcherDepartment of Medical Genetics, University of Helsinki26 Rautanen Anna Doctoral candidate Department of Medical Genetics, University of Helsinki27 Salmela Elina Doctoral candidate Department of Medical Genetics, University of Helsinki28 Sundman Lilli Doctoral candidate Department of Medical Genetics, University of Helsinki29 Tervaniemi Mari Doctoral candidate Department of Medical Genetics, University of Helsinki30 Tiala Inkeri Doctoral candidate Department of Medical Genetics, University of Helsinki31 Vendelin Johanna Doctoral candidate -> Postdoctoral researcherDepartment of Medical Genetics, University of Helsinki32 Wedenoja Satu Doctoral candidate -> Postdoctoral researcherDepartment of Medical Genetics, University of Helsinki33 Kontula Kimmo x Research Director, Professor Department of Clinical Medicine, University of Helsinki34 Backlund Mikael Doctoral candidate Department of Clinical Medicine, University of Helsinki35 Donner Kati Postdoctoral researcher Department of Clinical Medicine, University of Helsinki36 Hiltunen Timo Clinical instructor Department of Clinical Medicine, University of Helsinki37 Lahtinen Annukka Doctoral candidate Department of Clinical Medicine, University of Helsinki38 Lehtonen Jukka Postdoctoral researcher Department of Clinical Medicine, University of Helsinki39 Marjamaa Annukka Doctoral candidate -> Postdoctoral researcherDepartment of Clinical Medicine, University of Helsinki40 Paukku Kirsi Postdoctoral researcher Department of Clinical Medicine, University of Helsinki41 Suonsyrjä Timo Doctoral candidate Department of Clinical Medicine, University of Helsinki

42 Lohi Hannes x Research Director, ProfessorDepartment of Veterinary Biosciences, Department of Medical Genetics, Program in Molecular Medicine, University of Helsinki

43 Ahonen Saija Doctoral CandidateDepartment of Veterinary Biosciences, Department of Medical Genetics, Program in Molecular Medicine, University of Helsinki

44 Hytönen Marjo Doctoral CandidateDepartment of Veterinary Biosciences, Department of Medical Genetics, Program in Molecular Medicine, University of Helsinki

45 Jokinen Päivi Doctoral CandidateDepartment of Veterinary Biosciences, Department of Medical Genetics, Program in Molecular Medicine, University of Helsinki

46 Koskinen Lotta Doctoral Candidate -> Postdoctoral ResearcherDepartment of Veterinary Biosciences, Department of Meidical Genetics, Program in Molecular Medicine, University of Helsinki

47 Kyöstilä Kaisa Doctoral CandidateDepartment of Veterinary Biosciences, Department of Medical Genetics, Program in Molecular Medicine, University of Helsinki

48 Nevalainen Elisa Postdoctoral ResearcherDepartment of Veterinary Biosciences, Department of Medical Genetics, Program in Molecular Medicine, University of Helsinki

49 Niskanen Alina Doctoral Candidate Department of Biology, University of Oulu

50 Seppälä Eija Postdoctoral ResearcherDepartment of Veterinary Biosciences, Department of Meidical Genetics, Program in Molecular Medicine, University of Helsinki

51 Tiira Katriina Postdoctoral ResearcherDepartment of Veterinary Biosciences, Department of Meidical Genetics, Program in Molecular Medicine, University of Helsinki

52 Palotie Aarno x ProfessorInstitute for Molecular Medicine Finland FIMM, University of Helsinki

53 Anttila Verneri Doctoral candidate -> Postdoctoral ResearcherInstitute for Molecular Medicine Finland FIMM, University of Helsinki

54 Kallela Mikko University ResearcherInstitute for Molecular Medicine Finland FIMM, University of Helsinki

55 Luukkonen Tiia Doctoral candidateInstitute for Molecular Medicine Finland FIMM, University of Helsinki

56 Muona Mikko Doctoral candidateInstitute for Molecular Medicine Finland FIMM, University of Helsinki

57 Pietiläinen Olli Doctoral candidateInstitute for Molecular Medicine Finland FIMM, University of Helsinki

58 Wessman Maija University ResearcherInstitute for Molecular Medicine Finland FIMM, University of Helsinki

59 Peltonen-Palotie Leena x Research Director, ProfessorDepartment of Medical Genetics, University of Helsinki and Institute for Molecular Medicine Finland FIMM

60 Hennah William Doctoral candidate -> Postdoctoral researcherDepartment of Medical Genetics, University of Helsinki and Institute for Molecular Medicine Finland FIMM

61 Largeau Marine Doctoral candidateInstitute for Molecular Medicine Finland FIMM, University of Helsinki

62 Naukkarinen Jussi Doctoral candidateDepartment of Medical Genetics, University of Helsinki and Institute for Molecular Medicine Finland FIMM

63 Nyman Emma Doctoral candidateDepartment of Medical Genetics, University of Helsinki and Institute for Molecular Medicine Finland FIMM

64 Palo Marika Doctoral candidateDepartment of Medical Genetics, University of Helsinki and Institute for Molecular Medicine Finland FIMM

65 Silander Kaisa University ResearcherInstitute for Molecular Medicine Finland FIMM, University of Helsinki

66 Soronen Jarkko Doctoral candidateInstitute for Molecular Medicine Finland FIMM, University of Helsinki

67 Tomppo Liisa Doctoral candidateDepartment of Medical Genetics, University of Helsinki and Institute for Molecular Medicine Finland FIMM

68 Varilo Teppo University Researcher Department of Medical Genetics, University of Helsinki

69 Wedenoja Juho Doctoral candidateDepartment of Medical Genetics, University of Helsinki and Institute for Molecular Medicine Finland FIMM

70 Ripatti Samuli x Research DirectorInstitute for Molecular Medicine Finland FIMM, University of Helsinki

71 Kettunen Johannes Doctoral candidate -> Postdoctoral researcherInstitute for Molecular Medicine Finland FIMM, University of Helsinki

72 Laurila Pirkka-Pekka Doctoral candidateInstitute for Molecular Medicine Finland FIMM, University of Helsinki

73 Rehnström Karola Postdoctoral researcherInstitute for Molecular Medicine Finland FIMM, University of Helsinki

74 Rossi Mari Doctoral candidateInstitute for Molecular Medicine Finland FIMM, University of Helsinki

75 Surakka Ida Doctoral candidateInstitute for Molecular Medicine Finland FIMM, University of Helsinki

76 Saarela Janna x Research DirectorInstitute for Moleular Medicine Finland FIMM, University of Helsinki

77 Jakkula Eveliina Postdoctoral researcherInstitute for Moleular Medicine Finland FIMM, University of Helsinki

78 Kallio Suvi Doctoral candidateInstitute for Moleular Medicine Finland FIMM, University of Helsinki

79 Kemppinen Anu Doctoral candidateInstitute for Moleular Medicine Finland FIMM, University of Helsinki

80 Leppä Virpi Doctoral candidateInstitute for Moleular Medicine Finland FIMM, University of Helsinki

81 Sulonen Anna-Maija Doctoral candidateInstitute for Moleular Medicine Finland FIMM, University of Helsinki

82 Saavalainen Päivi x Senior researcherResearch program for Molecular Medicine & Department of Medical Genetics, University of Helsinki

83 Braicu Ovidiu Doctoral candidateResearch program for Molecular Medicine & Department of Medical Genetics, University of Helsinki

84 Dukes Emma Postdoctoral researcherResearch program for Molecular Medicine & Department of Medical Genetics, University of Helsinki

85 Einarsdottir Elisabet Postdoctoral researcherResearch program for Molecular Medicine & Department of Medical Genetics, University of Helsinki

86 Haimila Katri Doctoral candidate Finnish Red Cross Blood Transfusion Service

87 de Kauwe Andrea Postdoctoral researcherResearch program for Molecular Medicine & Department of Medical Genetics, University of Helsinki

88 Löytynoja Katja Doctoral candidateResearch program for Molecular Medicine & Department of Medical Genetics, University of Helsinki

89 Parmar Amarjit Doctoral candidateResearch program for Molecular Medicine & Department of Medical Genetics, University of Helsinki

90 Ziberna Fabiana Postdoctoral researcherResearch program for Molecular Medicine & Department of Medical Genetics, University of Helsinki

91 Taskinen Marja-Riitta x Professor, Research Direcor Institute of Clinical Medicine, University of Helsinki

92 Graner Marit Senior scientist, University lecturerHelsinki University Central Hospital, Institute of Clinical Medicine, University of Helsinki

93 Hakkarainen Antti Graduate student Institute of Clinical Medicine, UH94 Hiukka Anne Postdoctoral Researcher Institute of Clinical Medicine, University of Helsinki

95 Kahri Juhani Senior scientist, University lecturerHelsinki University Central Hospital, Institute of Clinical Medicine, University of Helsinki

96 Lundbom Jesper Doctoral Candidate Institute of Clinical Medicine, UH

97 Lundbom Nina x Senior scientist, University LectureHelsinki University Central Hospital, Institute of Clinical Medicine, UH

98 Maranghi Marianna Postdoctoral Researcher Sapienza University, Rome, Italy

99 Matikainen Niina Senior scientist, University lecturerHelsinki University Central Hospital, Institute of Clinical Medicine, University of Helsinki

100 Nakanishi Shuhei Post doctoral researcherDepartment of Endocrinology and Metabolism, Hiroshima University Hospital, Japan

101 Rautaheimo Emmi Graduate student Institute of Clinical Medicine, UH102 Rimpilä Olga Doctoral candidate Institute of Clinical Medicine, University of Helsinki103 Söderlud Sanni Doctoral Candidate Institute of Clinical Medicine, University of Helsinki104 Tikkanen Helena Doctoral candidate Institute of Clinical Medicine, University of Helsinki

105 Watanabe Hiroshi Post doctoral researcherDepartment of Endocrinology and Metabolism, Hiroshima University Hospital, Japan

106 Tuomi Tiinamaija x ProfessorResearch Program for Molecular Medicine & Institute of Clinical Medicine/ Department of Medicine, University of Helsinki

107 Andersen Mette Doctoral candidateResearch Program for Molecular Medicine & Institute of Clinical Medicine/ Department of Medicine, University of Helsinki

108 Isomaa Bo University ResearcherResearch Program for Molecular Medicine & Institute of Clinical Medicine/ Department of Medicine, University of Helsinki

109 Lehtovirta Mikko Doctoral candidateResearch Program for Molecular Medicine & Institute of Clinical Medicine/ Department of Medicine, University of Helsinki

110 Liljeström Brita Doctoral candidateResearch Program for Molecular Medicine & Institute of Clinical Medicine/ Department of Medicine, University of Helsinki

111 Lundgren Virve Doctoral candidateResearch Program for Molecular Medicine & Institute of Clinical Medicine/ Department of Medicine, University of Helsinki

112 Matintupa Olle Undergraduate studentResearch Program for Molecular Medicine & Institute of Clinical Medicine/ Department of Medicine, University of Helsinki

113 Saloranta Carola Postdoctoral ResearcherResearch Program for Molecular Medicine & Institute of Clinical Medicine/ Department of Medicine, University of Helsinki

114 Stoor Linda Undergraduate StudentResearch Program for Molecular Medicine & Institute of Clinical Medicine/ Department of Medicine, University of Helsinki

115 Vehkavaara Satu Postdoctoral ResearcherResearch Program for Molecular Medicine & Institute of Clinical Medicine/ Department of Medicine, University of Helsinki

116 Widen Elisabeth x Senior researcherInstitute for Molecular Medicine Finland FIMM, University of Helsinki

117 Cousminer Diana Doctoral candidateInstitute for Molecular Medicine Finland FIMM, University of Helsinki

118 Leinonen Jaakko Doctoral candidateInstitute for Molecular Medicine Finland FIMM, University of Helsinki

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RC-SPECIFIC STAGE 2 MATERIAL

Name of the RC’s responsible person: Kaprio, Jaakko

E-mail of the RC’s responsible person:

Name and acronym of the participating RC: Complex Disease Genomics Group, CompDisGen

The RC’s research represents the following key focus area of UH: 2. Elämän perusrakenne – The basic structure of life

Comments for selecting/not selecting the key focus area: Genetics and genomics is a fundamental part of the basic structure of living organisms. Our RC is focused on the genetics and genomics of complex diseases and has thus also relevance to clinical medicine, another focus area of the University.

Description of the RC’s research focus, the quality of the RC’s research (incl. key research questions and results) and the scientific significance of the RC’s research for the research field(s).

Focus. The RC combines two strong traditions of Finnish disease genetics and epidemiology. We aim at unraveling fundamental disease mechanisms using cutting-edge, genome-wide technology and exceptional study collections. This line of research has been one of the national success stories of the highest possible international standard. The foundations were laid already in the 1960s by visionary pediatricians who identified over 30 Mendelian diseases enriched in Finland and by trailblazing epidemiologists who created unique national population cohorts, including twin cohorts, and fostered the use of medical registers. During the last two decades, members of this RC have produced a wave of pioneering discoveries and trained new generations of internationally successful scientists by combining exceptional study collections and molecular techniques. The RC covers a large spectrum of topics related to disease genomics reaching from Mendelian to complex traits. Disease areas include cardiovascular, metabolic, neurodevelopmental, neuropsychiatric and immunomediated traits. Past highlights include the cloning of dozens of Mendelian disease genes using family-based positional cloning strategies, and lately, using genome-wide association (GWA) studies in the identification of dozens of common variants associated with complex traits. A key component of the past, current and future success has been, and will be, strong international partnering that enables the best possible combination of unique Finnish study collections and advanced molecular techniques. Although common variants identified by GWA studies have revealed a wealth of disease pathways and stimulated a wave of functional studies, the identified variants explain only a relatively small part of the genetic variance of complex traits. Thus the RC has invested in the next wave of discovery tools. Members of the RC are key partners in massive next-generation sequencing studies that aim to identify low-frequency variants contributing to cardiovascular, metabolic, neurodevelopmental and neuropsychiatric traits. Furthermore, the RC has been investing strongly in unique model organisms to improve our understanding of several neurological traits. For example, the RC houses one of the largest canine biobanks in the world. The national tradition in genetics, investments in biobanks, strong basic and clinical science and the physical proximity of Biomedicum to the Helsinki University Central Hospital provide unique opportunities to promote translational research. Members of the RC have pioneered molecular diagnostics for several Mendelian traits. The transition from the research laboratory to true clinical

BACKGROUND INFORMATION

1 FOCUS AND QUALITY OF RC'S RESEARCH (MAX. 8800 CHARACTERS WITH SPACES)

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diagnostics has been exceptionally fast and effortless. In the future, the RC aims to develop the tools and knowledge for personalized medicine by improved understanding of gene-gene and gene-environment interaction, individual variation in the regulation of gene expression and epigenetics. Unique clinical and population-based tissue collections provide exceptional opportunities to significantly contribute to this field of research. One of the hallmarks of this RC is its strong partnership with major international research centers and their infrastructures. Members of the RC have faculty positions in the Karolinska Institute in Sweden, the Broad Institute in the United States and the Sanger Institute in the United Kingdom. These partnerships facilitate key roles in large international pioneering projects. Such current projects include the 1000genomes project and the UK10K project (www.uk10k.org). Quality. The quality of our research is outstanding in terms of publications, external grants, doctoral theses, honors and prizes. The PIs of the RC include scientists whose expertise is recognized worldwide, and who have strong records in respective fields. Many of the PIs belong to the Academy of Finland Center of Excellence in Complex Disease Genetics and to the Nordic Center of Excellence in Disease Genetics. Many of our PIs also have international affiliations. Our RC has generated dozens of new doctoral students and postdoctoral researchers and has published over 800 articles in the years 2005-2010, many in the highest-impact journals across biomedical and clinical science, including at least 12 papers in Nature, 44 in Nature Genetics, 3 in Science, 9 in NEJM and Lancet respectively, 15 in PlosGenet, and 24 in AJHG. The PIs are highly cited, very productive and successful in generating external grants. An ERC Starting Independent Researcher Grant was awarded to Hannes Lohi in 2010, and the Marie Curie Excellence Grant to Päivi Saavalainen in 2005. One of the largest International studies closely integrated with the RC is the ENGAGE integrated project of the FP7 program of the European Union, for which our RC at the University of Helsinki is the lead coordinator. This 12 M€ project focuses on pooling datasets across more than 120 000 GWA studies in traits related to the metabolic syndrome, cardiovascular diseases and obesity, as well as on characterizing joint actions between genetic profiles and lifestyle. A multisite NIDA/NCI funding aims to identify functional genes for nicotine dependence on chromosome 22. Newly-funded or impending EU FP7 projects we are involved in include TORNADO (gut microbe – dietary interactions in obesity and metabolic diseases); GENODISC (structural and functional genomics of intervertebral disc degeneration); BioSHARE (Biobank Standardization and Harmonization); SYNSYS (A European Exert Network in Building Synapse). In addition, we continue to collaborate with existing EU projects such as EUROHEAD, DIOGENES, EUROCLOT, GEHA, EPICURE, LUPA (dog genomics) and SGENE. The research area developed by the RC in human disease genetics is also highly recognized among the general public according to the Finnish Science Barometer 2010. The RC has internationally prominent scientists as its PIs, with memberships in international bodies such as the Nobel Committee for Physiology or Medicine. Scientific significance. Through active collaboration between the partners in the RC, and with scientists and laboratories outside the RC nationally and internationally, the RC has contributed strongly to new knowledge of the genetic basis of common diseases and their risk factors. The variants identified in GWA studies have stimulated research to understand their impact on cellular, individual and population levels. Well-characterized, large epidemiological Finnish collections provide a special opportunity to study the contribution of individual variants, combination of variants and their cross talk with environmental and lifestyle factors on disease susceptibility at different stages of life. Our RC has also developed unique animal models of for example mice and dogs to further help to identify and model the molecular background and pathogenesis of human inherited diseases. Through active collaboration between the partners in the RC with scientists and laboratories outside the RC at the University of Helsinki, as well as with other research groups nationally and internationally, the RC has contributed

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strongly to new knowledge of the genetic basis of common diseases and their risk factors. Besides our internationally reputed scientific input, the RC’s expertise and scientific significance span technologies, epidemiology and sample collection as well as biobanking and analyses and translational activities including animal models and preclinical trials.

Ways to strengthen the focus and improve the quality of the RC’s research.

The RC will further develop its collaboration between its PIs to efficiently utilize new possibilities in genomic medicine and systems biology, including technical resources and know-how for biobanking, robotics and data handling as well as next-generation sequencing. The present availability of genome-wide variation data within the RC members in various case-control studies and prospective cohorts provides excellent possibilities to share the information and thus improve efforts to dissect the genetic background of multiple traits across the members. The high-quality epidemiological cohorts of Finland will be used to study the public-health impact of novel genes and explore gene-environment interactions. Extensive animal resources established within the RC will be utilized more efficiently in order to translate and replicate the discoveries across species. The RC will maintain its close links to frontline international genomic institutes and continue to contribute to world-class biobanking initiatives that provide outstanding replication resources.

How is doctoral training organised in the RC? Description of the RC’s principles for recruitment and

selection of doctoral candidates, supervision of doctoral candidates, collaboration with faculties, departments/institutes, and potential graduate schools/doctoral programmes, good practises and quality assurance in doctoral training, and assuring good career perspectives for the doctoral candidates/fresh doctorates.

The RC groups have extensive experience in the training of graduate students and postdoctoral fellows and the group leaders have all been involved in several graduate schools. The courses and tutoring organized by graduate schools at the University of Helsinki have provided the framework for the training of the RC’s researchers. Each graduate student has a thesis committee with scientists from outside the RC. The RC has trained numerous scientists, with 54 PhDs defended at the University of Helsinki in 2005-2010. Currently we have 34 enrolled PhD students. Seventeen RC members have acted as supervisors during 2005-2010. Most of the PhD students in the RC go on to defend their theses in the Medical faculty, some in other faculties of the University. The Faculty of Medicine offers the following scientific postgraduate degrees: Doctor of Medical Science, Doctor of Dental Science and Doctor of Philosophy. A doctoral student participates in a research project, writes a doctoral dissertation and completes the studies required for the degree (40 ECTS credits for Medical or Dental Science, 60 ECTS credits for PhD). The student is expected to become well-versed in the basic problems and research methods of scientific and medical research. To promote close integration of basic and clinical research, multidisciplinary five-year research programs were established in 2001, comprising the Research Programs Unit of the Faculty of Medicine, of which the Molecular Medicine program is a key component of the present RC. Many of the RC’s PIs act as group leaders in the Centre of Excellence in Complex Disease Genetics, one of the highest-level research units funded by the Academy of Finland. PhD students are recruited to these research groups either using external funds of the research group or funds allocated on a competitive basis to Graduate schools by the Ministry of Education. The Meilahti medical campus has also a modern infrastructure with top-level methodological support. In addition to an excellent training environment, the graduate schools

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organize structured PhD training with various international courses, workshops and symposia on the campus. Ministry of Education or University of Helsinki funded graduate schools and research training programs offer broad training opportunities in e.g. biomedicine, clinical medicine, biology, epidemiology and biocomputing. Graduate schools are often arranged nationally and are active internationally by organizing visits and seminars and supporting student mobility (e.g. by offering travel and lab visit grants). The programs apply for funding in fixed terms and admit students through an open call. Principal Investigators within the RC also have some international training positions available through NIH and EU-funded grants. The medical faculty has a joint PhD program with the Karolinska Institute, and this cooperation is being expanded to other universities as well. There are nine Ministry of Education funded graduate schools on the Meilahti campus and the RCs students study in several of these. This is natural given the cross-disciplinary nature of the RC. Each of our students has 1-2 designated supervisors and currently students enrolled to the graduate schools also have a two-person thesis committee, with whom they meet annually to review progress. Written reports on these meetings are created and serve to document the evaluation of the student. Each graduate student will have a study group meeting once a year and the study group may contain also scientists outside the RC. Postdoctoral students are also responsible for organizing and running weekly journal clubs and for giving their contribution to seminars within the RC (CoE, Mol Med program, department seminars, etc) they also take part in annual scientific retreats and national and international congresses. These basic structures provide an interactive and stimulating environment for students working on different projects. Some of our students also participate in the Faculty’s MD, PhD program. The M.D., Ph.D. program of the Medical Faculty of the University of Helsinki offers students a chance to begin working towards a Ph.D. thesis already in the beginning of their medical or dental studies. Students are selected in the program every year from among first-year medical or dental students. They begin in the program after finishing their first year of medical school, doing postgraduate research alongside their M.D. studies. Two postdoctoral tutors and one or two student tutors guide the students during their first years in the program. Before finishing their medical or dental studies, the M.D., Ph.D. students work in research groups for five summers, each summer for three months on a monthly salary. During the first two summers the students have a unique chance to carry out research rotations in 3-4 different research groups. This enables the students to familiarize themselves with various themes of research. After their second summer in the program the students begin their Ph.D. thesis project in a Medical faculty research group. Each student is appointed a thesis committee to support the progress of the thesis project. After the students have finished their medical or dental degree they continue with full-time research for a period of up to two years, during which time they are expected to finish their Ph.D. thesis. When the students are granted their doctoral degree they will also receive a diploma for the M.D., Ph.D. program. M.D., Ph.D. students also have the opportunity to partake in seminars, symposia and courses and are offered travel grants for participating in international conferences. The Faculty and its committees relevant for graduate education have committed much time and effort into assuring a structure and high-quality process for PhD studies. After graduation, students continue onto postdoctoral positions, often in excellent institutions abroad. Some continue with clinical work in medicine or veterinarian medicine. It is difficult to evaluate the long-term prospects of those who have graduated in the years

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2005-2010, but based on earlier experiences of the PIs, our graduate students have pursued excellent and productive career paths.

RC’s strengths and challenges related to the practises and quality of doctoral training, and the actions planned for their development.

The Medical Faculty of the University of Helsinki has pioneered many developments in order to ensure the best possible scientific and pedagogical quality of PhD studies. These practices and processes are documented in the quality assurance documents of the Faculty, and approved in the recent evaluation of the University. Many RC members have participated in these developments as members of the standing and ad hoc committees and working groups established by the Faculty. For example, the Faculty pioneered the introduction of the TUHAT electronic documentation service and has set up strict requirements for the recruitment, evaluation and education of PhD students. The RC will follow the best practices set out by the Faculty and contribute to the continued development of these processes.

Description of how the RC interacts with and contributes to the society (collaboration with public,

private and/or 3rd sector).

The Medical Faculty of the University of Helsinki is the flagship of Finnish medical research. Basic biomedical research, clinical research and epidemiological research all represent areas of special strength in Finnish science and research. The RC and its PIs are active in giving presentations to the general public and are frequently interviewed by the media in connection to their scientific breakthroughs. The research area in human disease genetics is also highly recognized and valued among the general public. Many of the RC’s PIs are also internationally prominent scientists with memberships in international committees such as the Nobel Committee for Physiology or Medicine. The Faculty of Medicine, as well as other organizations on the Meilahti medical campus, are experts in the field of health care. The Faculty strives to influence national health care and to maintain good contacts with industry. The Faculty's most important partner is the Hospital District of Helsinki and Uusimaa, where several of our PIs practice as clinicians. One of the Faculty's key duties is to consolidate and develop University-led activities in hospitals belonging to the University Hospital. The RC provides expertise in human genetics, complex disease genetics and public health genomics. Thus it provides direct input into medical care and preventive/screening services.

Ways to strengthen the societal impact of the RC’s research and doctoral training.

Our research and doctoral training is highly relevant to the society at large. Our high-quality research serves to ensure first-rate medical treatment, particularly with respect to both the genetics of monogenic disorders and the genomics of complex diseases. By identifying individual differences in the response to changing environments and over the course of an individual’s life, public health genomics will be of increasing importance as the genomic architecture of many disorders is unraveled. Close interaction with health care providers (e.g. HUCH), state research institutes and policy makers will be strengthened further to increase the impact of our research in Finland. High-impact publications, a proactive role in international scientific organizations (such as the FIMM-EMBL), and constructive interaction with funders (such as the EU) are all means of providing societal impact internationally.

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Description of the RC’s research collaborations and joint doctoral training activities and how the RC has promoted researcher mobility.

Our research spans national and international collaborations. Within the University of Helsinki, we work across faculties and research institutes. The most important ones are FIMM and the Research Programs Unit of the Faculty of Medicine. We are in close collaboration with the National Institute for Health and Welfare, other state research institutes, other Finnish Universities and the Biocenter Finland. Many of our PIs have also longstanding international affiliations. One of the largest International studies closely integrated with the RC is the ENGAGE integrated project of the FP7 program of EU of which the University of Helsinki is the lead coordinator. This 12 M€ project focuses on pooling datasets across more than 120 000 GWA studies in traits related to the metabolic syndrome, cardiovascular diseases and obesity and characterizing joint actions between genetic profiles and lifestyle. Through this project, we have contributed to and lead multiple other collaborative studies, that have lead to the identification of hundreds of new genetic variants and genes for dozens of common diseases and traits. Further funding is needed to characterize the functional nature and public-health impact for these discoveries. Thus, a multisite NIDA/NCI funding is directed to the identification of functional genes for nicotine dependence on chromosome 22, while another NIAAA grant has funded genotyping of the FT12 study sample for the purpose of discovering gene-environment interactions. Newly funded or impending EU FP7 projects we are involved in include TORNADO (gut microbe – dietary interactions in obesity and metabolic diseases); GENODISC (structural and functional genomics of intervertebral disc degeneration); BioSHARE (Biobank Standardization and Harmonization); SYNSYS (A European Exert Network in Building Synapse) and I.Family (Determinants of eating behaviour in European children, adolescents and their parents), in addition to continuing our collaborations in existing EU projects such as EUROHEAD, DIOGENES, EUROCLOT, GEHA, EPICURE, LUPA (dog genomics) and SGENE. The Marie Curie Excellence Grant CD-GENETICS enabled international recruitment of various postdoctoral researchers and PhD students from abroad. Because of the role of our RC investigators in the Wellcome Trust Sanger Institute, the Broad Institute and the Karolinska Institute, they make a strong contribution to large international collaborative efforts. This guarantees us excellent access to data produced by projects like Hapmap3, 1000 Genomes and EUVADIS (sequencing 1000 individuals with early onset cardiovascular and metabolic diseases). These collaborations also harmonize operations of CoE with critical Nordic operators in biobanking and disease databases (Nordic Center of Excellence, www.ncoedg.org). Within these projects, there have been excellent opportunities for researcher training and mobility. Just to take one example, the University of Helsinki is the Work Package leader in ENGAGE for training and mobility. Many workshops and research-exchange visits across Europe have thus been made possible. PhD students, postdoctoral researchers and senior researchers frequently visit laboratories in Europe, the US and Asia, and their scientists visit us in turn.

RC’s strengths and challenges related to research collaboration and researcher mobility, and the actions planned for their development.

The RC has a rich and productive history of research collaboration. In particular, the past 5-10 years have seen a vast increase in the number of multicentre studies needed for the discovery of genetic variants underlying many complex disorders. One challenge will be to maintain our good infrastructure and high level of expertise, as well as to continue to spearhead international collaborations. In order to

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maintain our expertise in the scientific and administrative aspects of these collaborations sufficient funds are needed from the University. The same resources are needed for national collaborations as it can be envisioned that there will be increasing pressure to avoid duplicate efforts within Finland. The Biocentre Finland is an important step in this direction. Researcher mobility also requires continued resources, not only for the visiting student or postdoctoral researcher but also for the host organization. Improving the efficiency of fund allocation represents a challenge for the centralized bureaucracy of the University of Helsinki.


The RC comprises the best overall expertise in complex disease genetics at the University of Helsinki, as well as the rest of Finland, and is acknowledged worldwide. The RC’s expertise spans technologies, epidemiology and sample collection, biobanking, analyses and translational activities including animal models and preclinical trials. The RC plays a key role in the development and maintenance of infrastructure for state-of-the-art genetic and genomic research. Many of the RC members are clinicians or university teachers who balance between their clinical and teaching duties and research. The Medical Faculty of the University of Helsinki is the flagship of Finnish medical research. The Faculty of Medicine is located on the Meilahti Medical Campus together with the Helsinki University Hospital and other research and educational facilities. We work across faculties and research institutes, and the medical campus in Helsinki is highly rated in all international evaluations. The most important agents are FIMM and the Research Programs Unit of the Faculty of Medicine. We are in close collaboration with national agents and internationally. In January of 2011, the Academy of Finland awarded FIMM 4 million euros for the infrastructure development of biobanks. An important element is the FIMM Technology Centre, which is a local, national and international infrastructure and service facility developing new technologies and serving the user community with state-of-the-art technologies. The FIMM Technology Centre has excellent research facilities, including high and medium-throughput systems for genotyping sequencing , transcript profiling, high-throughput RNAi screening and translational technologies. To serve the needs of computation and data management the FIMM Technology Centre has set up a 1000 cpu cloud computing environment in collaboration with CSC and continues to increase its capacity for the storage array network (SAN). The FIMM Technology Centre maintains over hundred physical and virtual servers used for hosting bioinformatics databases and other applications. The Centre utilizes the latest IT tools such as virtualization and scale-out storage technologies to provide a robust and scalable platform for doing date-intensive science. Collaboration with the Centre for Scientific Computing (www.CSC.fi) enables the usage of CSC facilities when very high capabilities are needed. Based on the development of this outstanding expertise, infrastructure and reputation the RC has been eminently successful in external grant competitions. This in turn permits us to attract gifted students for PhD studies and postdoctoral work. FIMM also coordinates Biomedinfra – a joint national hub for the European ESFRI infrastructure projects BBMRI, ELIXIR, EATRIS.

RC’s strengths and challenges related to operational conditions, and the actions planned for their development.

The cross-disciplinary nature of the RC and its basis at the medical campus of the University of Helsinki are great strengths.

5 OPERATIONAL CONDITIONS (MAX. 4400 CHARACTERS WITH SPACES)

8



Modern disease genomics utilize high-throughput genomic techniques, interdisciplinary strategies and very large sample sizes. In this type of research no institute can be self -sufficient. Success in modern disease genomics is based on international collaboration. Such collaboration is greatly facilitated by joint appointments and exchange of researchers between institutions. Within our RC this is documented by the large number of milestone publications in some of the most prestigious scientific journals, which are nearly all based on large international collaborations.

Description of the execution and processes of leadership in the RC, how the management-related

responsibilities and roles are distributed in the RC and how the leadership- and management-related processes support high quality research, collaboration between principal investigators and other researchers in the RC, the RC’s research focus and strengthening of the RC’s know-how.

The RC includes PIs from the Research Program for Molecular Medicine, the Centre of Excellence in Complex Disease Genetics and the genetics program of FIMM. These entities were largely established and spearheaded by Leena Peltonen-Palotie, an innovative and inspiring leader and one of the most famous geneticists in the world. Leena’s exceptional domestic and international connections to leading scientists and funding organizations in the field have helped to develop the necessary infrastructure and know-how so that the RC has become an outstanding internationally recognized leader in human genetics. Having strong leadership has improved the quality of our research and facilitated the competitiveness of the RC in scientific evaluations. Most of the RC members belong to the flagships of Finnish high-quality research institutions, including CoE in Complex Disease Genetics and FIMM. Effective leadership processes have included regular joint top-quality seminar series, regular meetings between PIs and active encouragement for data sharing to expedite each PI’s research progresses. Our leadership has also carried great responsibility for doctoral training and the establishment of a new generation of young PIs to ensure the continuation of the Finnish tradition in genetics. The RC’s PIs meet regularly to discuss common scientific, methodological and other research-related issues. The leadership of the RC has been supported by administrative assistance in financial, personnel and office matters. The RC maintains several technical core facilities such as those for sequencing, genotyping and bioinformatics, all of which improve the efficiency and cost-benefit of the RC. The RC members share facilities and make joint investments for new equipments to facilitate the maintenance, use and know-how of the state-of-the-art infrastructure. This has significantly improved collaboration between individual research groups.

RC’s strengths and challenges related to leadership and management, and the actions planned for developing the processes.

The research field of the RC develops rapidly and strong leadership is required to maintain the exceptionally diverse and high quality of our research. New high-throughput sequencing technologies are becoming the golden standard in genetics in the near future. The role of leadership is to make sure the RC is kept up-to-date on the latest developments infrastructure. The leadership provides guidance on the application and interpretation of important research questions within the RC’s projects. The RC’s extensive collaboration on all fronts with scientists all over the world will help in achieving this. In our RC, challenges arising from the untimely death of Leena Peltonen have been addressed jointly by the PIs to ensure a stable transition for her PhD students and projects. Good leadership will ensure that all arising issues are regularly discussed between PIs, proper training is provided for scientists, and a collaborative environment facilitates the application of new developments to advance each project.

6 LEADERSHIP AND MANAGEMENT IN THE RESEARCHER COMMUNITY (MAX. 4400 CHARACTERS WITH SPACES)

9



Listing of the RCs external competitive funding, where: - the funding decisions have been made during 1.1.2005-31.12.2010, and - the administrator of the funding is/has been the University of Helsinki

Academy of Finland (AF) - total amount of funding (in euros) AF has decided to allocate to the RC

members during 1.1.2005-31.12.2010: 11200000

Finnish Funding Agency for Technology and Innovation (TEKES) - total amount of funding (in euros) TEKES has decided to allocate to the RC members during 1.1.2005-31.12.2010: 90000

European Union (EU) - total amount of funding (in euros) EU has decided to allocate to the RC members during 1.1.2005-31.12.2010: 18600000

European Research Council (ERC) - total amount of funding (in euros) ERC has decided to allocate to the RC members during 1.1.2005-31.12.2010: 1380000

International and national foundations – names of international and national foundations which have decided to allocate funding to the RC members during 1.1.2005-31.12.2010, and the amount of their funding (in euros).

- names of the foundations: Solhberg Foundation, Finnish Cultural Foundation, Gastroenterology foundation, Pesatu, Nurmi Foundation, Finnish Foundation for Cardiovascular Research, Wallenberg Foundation, European Science Foundation, Novo Nordisk Fonden, KELA, Pfizer Foundation, Sigrid Juselius Foundation, NIH

- total amount of funding (in euros) from the above-mentioned foundations: 3950000

Other international funding - names of other international funding organizations which have decided to allocate funding to the RC members during 1.1.2005-31.12.2010, and the amount of their funding (in euros).

- names of the funding organizations: Karolinska institutet, AKC Canine Foundation, Swedish Research Council, NordForsk, CIMO, Uppsala University, Indiana University

- total amount of funding (in euros) from the above-mentioned funding organizations: 3200000

Other national funding (incl. EVO funding and Ministry of Education and Culture funded doctoral programme positions) - names of other national funding organizations which have decided to allocate funding to the RC members during 1.1.2005-31.12.2010, and the amount of their funding (in euros).

- names of the funding organizations: EVO, HUSLAB, Biocentrum Helsinki, University of Helsinki Funds, University of Helsinki, National Institute for Health and Welfare (THL), Ministry of Education and Culture, Helsinki Graduate Program in Biotechnology and Molecular Biology GPBM, HBGS Graduate School, The Finnish Medical Society Duodecim

- total amount of funding (in euros) from the above-mentioned funding organizations: 6000000

7 EXTERNAL COMPETITIVE FUNDING OF THE RC

8 RC’S STRATEGIC ACTION PLAN FOR 2011–2013 (MAX. 4400 CHARACTERS WITH SPACES)

10



Description of the RC’s future perspectives in respect to research and doctoral training.

Our RC will continue to study the genetic background of common complex diseases and traits using large-scale population and patient cohorts with rich phenotypic and clinical data, and genome-wide profiling. The research will focus on interesting and clinically relevant study questions aiming for the best possible science. While the RC is not a formal organization in itself, we have the necessary structures to maintain our current collaborations and research. As mentioned earlier these exist principally in FIMM and the Faculty of Medicine, but also with our other partners on the Meilahti campus, elsewhere in Finland and abroad. External funding is an absolute requirement for this. At the same time international evaluations have indicated that Finnish research is more dependent on external funding that is the case in many other top-level European research centres. Thus the University must prioritize research and increase the level of internal funding. Doctoral training will also continue to be an integral part of our work.

RC members have taken care to submit their own information on publications and other scientific activities, and PIs have written and commented on the texts. Project secretaries have done a wonderful job of compiling all the materials despite the delayed and changing instructions from the evaluation secretariat.

9 SHORT DESCRIPTION OF HOW THE RC MEMBERS HAVE CONTRIBUTED TO THE COMPILATION OF THE STAGE 2

MATERIALS (MAX. 1100 CHARACTERS WITH SPACES).

CompDisGen/Kaprio

1


RC-SPECIFIC TUHAT COMPILATIONS OF PUBLICATIONS DATA 2005-2010

1 Analysis of publications - Associated person is one of Jaakko Kaprio , Leonie-Helen Bogl , Ulla Heidi Broms , Anna Keski-Rahkonen , Tellervo Korhonen , Hanna-Reetta Lajunen , hanna-reetta. Antti Latvala , Anu-Maria Loukola , Linda Marina Mustelin , Miina Ollikainen , Alfredo Ortega-Alonso , Kirsi Hannele Pietiläinen , Anu Hannemari Raevuori , Suoma Eeva Matilda Saarni , Elina Sihvola , Kaisu Keskitalo ,

Juha Kere , Outi Kaarina Elomaa , , Katariina Sara Eriikka Hannula-Jouppi , , Tiina Järvinen , Nina Johanna Kaminen-Ahola, Satu Massinen ,

Ville Pertti Pulkkinen , , Anna Rautanen , Elina Salmela , , Lilli Sundman , Mari Hannele Tervaniemi , Satu

Johanna Wedenoja , Kimmo Kontula , Kati Donner , , Timo Hiltunen , Annukka Lahtinen , Jukka Tapani Lehtonen , Annukka Marjamaa ,

Kirsi Riitta Sinikka Paukku , Timo Suonsyrjä, Hannes Tapani Lohi , Saija Ahonen , Marjo Kristiina Hytönen , , Päivi Jokinen , Lotta Koskinen ,

, Kaisa Kyöstilä , Elisa Nevalainen , Eija Seppälä , Katriina Annikki Tiira , , Aarno Palotie , Verneri Anttila , , Kaarlo Mikko Juhani Kallela , Mikko Sakari Muona , Olli

Pietiläinen , Maija Wessman , Leena Palotie , William Hennah , Marine Largeau , Jussi Naukkarinen , Kaisa Silander ,

Jarkko Matias Soronen , Teppo Varilo , Juho Wedenoja , Samuli Olli Ripatti , Johannes Kettunen , Pirkka-Pekka Laurila , Karola Hannele Rehnström ,

Mari Rossi , Ida Liisa Surakka , Janna Saarela , Eveliina Jakkula , Virpi Maria Leppä , Anna-Maija Kristiina Sulonen , Päivi Marjaana Saavalainen , Elisabet Einarsdottir , Katja Löytynoja , Amarjit Parmar ,

Marja-Riitta Taskinen , Marit Anneli Graner , Antti Hakkarainen, Anne Sinikka Hiukka , Aarne Juhani Kahri , , Nina Lundbom , Niina Hanna Talvikki Matikainen , Emmi Rautaheimo , Olga Rimpilä , Sanni Söderlund ,

, Helena Tikkanen , Tiinamaija Tuomi , Mette Korre Andersen , Bo Isomaa , , Mikko Lehtovirta , Brita Kristina Liljeström , Virve Lundgren , , Carola Saloranta , Satu Vehkavaara ,

, Elisabeth Ingrid Maria Widen , Diana Laura Cousminer , Jaakko Leinonen ,

Publication Year

Publication type 2005 2006 2007 2008 2009 2010 Total Count 2005 -

2010

A1 Refereed journal article 143 143 157 184 200 173 1000

A2 Review in scientific journal 4 4 2 2 1 7 20

A3 Contribution to book/other compilations (refereed) 4 11 3 5 4 27

A4 Article in conference publication (refereed) 1 1 1 1 1 3 8

B1 Unrefereed journal article 11 9 6 5 9 8 48

B2 Contribution to book/other compilations (non-refereed) 1 1 2 2 6

B3 Unrefereed article in conference proceedings 1 1 2 4

C1 Published scientific monograph 1 1

C2 Edited book, compilation, conference proceeding or special issue of journal

1 1 1 1 4

D1 Article in professional journal 1 1 1 6 9

D2 Article in professional hand or guide book or in a professional data system, or text book material

1 1 2

CompDisGen/Kaprio

2



Publication type 2005 2006 2007 2008 2009 2010 Total Count 2005 -

2010

D3 Article in professional conference proceedings 2 2

E1 Popular article, newspaper article 4 1 3 2 2 12

E1 Popular contribution to book/other compilations 1 1

E2 Popular monograph 1 1 2

H1 Patents 1 1

CompDisGen/Kaprio

3



2 Listing of publications

A1 Refereed journal article

2005 Abdel-Rahman, WM, Ollikainen, M, Kariola, R, Järvinen, HJ, Mecklin, J, Nyström-Lahti, MK, Knuutila, S, Peltomäki, P 2005, 'Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations', Oncogene, vol 24, no. 9, pp. 1542-1551.

Abdel-Rahman, WM, Lohi, H, Knuutila, S, Peltomäki, P, Abdel-Rahman, W 2005, 'Restoring mismatch repair does not stop the formation of reciprocal translocations in the colon cancer cell line HCA7 but further destabilizes chromosome number', Oncogene, vol 24, no. 4, pp. 706-713.

Abecasis, G, Allen, M, Barker, J, Kere, J, Burden, D, Capon, F, Christophers, E, Elder, JT, Gudjonsson, JE, Huffmeier, U, Jenisch, S, Karason, A, Nair, RP, Novelli, G, Prud'homme, JF, Qin, ZHS, Samuelsson, L, Saarialho-Kere, U, Sanchez, F, Stahle, M, Stuart, P, Tillman, D, Traupe, H, Trembath, R, Valdimarsson, H, Veal, C, Voorhees, JJ, Wichenthal, M 2005, 'Fine mapping of the psoriasis susceptibility gene PSORS1: a reassessment of risk associated with a putative risk haplotype lacking HLA-Cw6', Journal of Investigative Dermatology, vol 124, no. 5, pp. 921-930.

Adiels, M, Caslake, MJ, Stewart, P, Soro-Paavonen, A, Westerbacka, JJ, Wennberg, B, Olofsson, S, Packard, C, Taskinen, M 2005, 'Overproduction of large VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 25, pp. 1697-1703.

Adiels, M, Packard, C, Caslake, MJ, Stewart, P, Soro, A, Westerbacka, J, Wennberg, B, Olofsson, S, Taskinen, M, Boren, J 2005, 'A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions', Journal of Lipid Research, vol 46, pp. 58-67.

Ansquer, J, Foucher, C, Rattier, S, Taskinen, M, Steiner, G 2005, 'Fenofibrate reduces progression to microalbuminuria over 3 years in a placebo-controlled study in type 2 diabetes: results from the Diabetes Atherosclerosis Intervention Study (DAIS)', American Journal of Kidney Diseases, vol 45, pp. 485-493.

Baker, SG, Lichtenstein, P, Kaprio, J, Holm, N 2005, 'Genetic susceptibility to prostate, breast, and colorectal cancer among Nordic twins', Biometrics, vol 61, no. 1, pp. 55-63.

Bennett, A, Sovio, U, Ruokonen, A, Martikainen, H, Pouta, A, Taponen, S, Hartikainen, A, Franks, S, Peltonen, L, Elliott, P, Järvelin, M, McCarthy, MI 2005, 'No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort', Diabetologia, vol 48, no. 5, pp. 886-891.

Brekke, HK, Lenner, RA, Taskinen, M, Månsson, J, Funahashi, T, Matsuzawa, Y, Jansson, P 2005, 'Lifestyle modification improves risk factors in type 2 diabetes relatives', Diabetes Research and Clinical Practice, vol 68, pp. 18-28.

Bruce, S, Leinonen, R, Lindgren, C, Kivinen, K, Dahlman-Wright, K, Lipsanen-Nyman, M, Hannula-Jouppi, KSE, Kere, J 2005, 'Global analysis of uniparental disomy using high-density genotyping arrays', Journal of Medical Genetics, vol 42, no. 11, pp. 847-851.

Cannon, TD, Hennah, W, van Erp, TGM, Thompson, PM, Lönnqvist, J, Huttunen, M, Gasperoni, T, Tuulio-Henriksson, A, Pirkola, T, Toga, AW, Kaprio, J, Mazziotta, J, Peltonen, L 2005, 'Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory', Archives of General Psychiatry, vol 62, no. 11, pp. 1205-1213.

Cannon, TD, Hennah, W, van Erp, T, Thompson, P, Lonnqvist, J, Huttunen, M, Gasperoni, T, Tuulio-Henriksson, A, Pirkola, T, Toga, A, Kaprio, J, Mazziotta, J, Peltonen, L 2005, 'DISC1/TRAX haplotypes associate with schizophrenia, reduced prefrontal gray matter, and impaired short and long-term memory', Schizophrenia bulletin, vol 31, pp. 266-266.

Chernova, MN, Jiang, L, Friedman, DJ, Darman, RB, Lohi, H, Kere, J, Vandorpe, DH, Alper, SL 2005, 'Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity', Journal of Biological Chemistry, vol 280, no. 9, pp. 8564-8580.

Choi, EH, Taylor, JG, Foster, CB, Walsh, TJ, Anttila, V, Ruutu, T, Palotie, A, Chanock, SJ, Paltotie, A 2005, 'Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients', Medical Mycology, vol 43, no. 4, pp. 349-353.

Dahlman, I, Kaaman, M, Jiao, H, Kere, J, Laakso, M, Arner, P 2005, 'The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects', Diabetes, vol 2005, no. 54, pp. 3032-3034.

Derbinski, J, Gäbler, J, Brors, B, Tierling, S, Jonnakuty, S, Hergenhahn, M, Peltonen, L, Walter, J, Kyewski, B 2005, 'Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels', Journal of Experimental Medicine, vol 202, no. 1, pp. 33-45.

Dick, DM, Viken, RJ, Kaprio, J, Pulkkinen, L, Rose, RJ 2005, 'Understanding the covariation among childhood externalizing symptoms: genetic and environmental influences on conduct disorder, attention deficit hyperactivity disorder, and oppositional defiant disorder symptoms', Journal of Abnormal Child Psychology, vol 33, no. 2, pp. 219-229.

CompDisGen/Kaprio

4



Enattah, NS, Sulkava, R, Halonen, P, Kontula, K, Järvelä, I, Enattah, NS 2005, 'Genetic variant of lactase-persistent C/T-13910 is associated with bone fractures in very old age', Journal of the American Geriatrics Society, vol 53, no. 1, pp. 79-82.

Eriksson, CJP, Kaprio, J, Pulkkinen, L, Rose, RJ 2005, 'Testosterone and alcohol use among adolescent male twins: testing between-family associations in within-family comparisons', Behavior Genetics, vol 35, no. 3, pp. 359-368.

Florez, JC, Agapakis, CM, Burtt, NP, Sun, M, Almgren, P, Råstam, L, Tuomi, T, Gaudet, D, Hudson, TJ, Daly, MJ, Ardlie, KG, Hirschhorn, JN, Groop, L, Altshuler, D 2005, 'Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people', Diabetes, vol 54, pp. 1884-1891.

Fröjdö, S, Sjölind, L, Parkkonen, M, Mäkinen, V, Kilpikari, R, Pettersson-Fernholm, K, Forsblom, C, Fagerudd, J, Tikellis, C, Cooper, ME, Wessman, M, Groop, P, Kilpikari, R 2005, 'Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy', Diabetologia, vol 48, pp. 2278-2281.

Färkkilä, M, Kallela, M 2005, 'Eletriptan review', Expert Opinion on Pharmacotherapy, vol 6, no. 4, pp. 625-630.

Haarasilta, L, Marttunen, M, Kaprio, J, Aro, H 2005, 'Major depressive episode and physical health in adolescents and young adults: results from a population-based interview survey', European Journal of Public Health, vol 15, no. 5, pp. 489-493.

Hakonen, AH, Heiskanen, S, Juvonen, V, Paetau, I, Luoma, P, Rantamäki, M, Van Goethem, G, Löfgren, A, Hackman, P, Paetau, A, Kaakkola, S, Majamaa, K, Varilo, T, Udd, B, Kääriäinen, H, Bindoff, LA, Suomalainen, AE 2005, 'Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin', American Journal of Human Genetics, vol 77, no. 3, pp. 430-441.

Hannelius, U, Lindgren, CM, Melen, E, Malmberg, A, von Dobeln, U, Kere, J 2005, 'Phenylketonuria screening registry as a resource for population genetic studies', Journal of Medical Genetics, vol 2005, no. 42, pp. -.

Hannila-Handelberg, T, Kontula, K, Tikkanen, I, Tikkanen, T, Fyhrquist, F, Helin, K, Fodstad, H, Piippo, K, Miettinen, HE, Virtamo, J, Krusius, T, Sarna, S, Gautschi, I, Schild, L, Hiltunen, TP, Hannila-Handerberg, T 2005, 'Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension', BMC Medical Genetics, vol 6.

Hannukainen, JC, Kujala, UM, Toikka, J, Heinonen, OJ, Kapanen, J, Vahlberg, T, Kaprio, J, Kalliokoski, KK 2005, 'Cardiac structure and function in monozygotic twin pairs discordant for physical fitness', Journal of Applied Physiology, vol 99, no. 2, pp. 535-541.

Hannula-Jouppi, K, Kaminen-Ahola, N, Taipale, M, Eklund, R, Nopola-Hemmi, J, Kääriäinen, H, Kere, J 2005, 'The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia', PLoS Genetics, vol 1, no. 4, pp. 467-474.

Harno, H, Heikkinen, S, Kaunisto, MA, Kallela, M, Häkkinen, AM, Wessman, M, Färkkilä, M, Lundbom, N, Häkkinen, A 2005, 'Decreased cerebellar total creatine in episodic ataxia type 2: a 1H MRS study', Neurology, vol 64, no. 3, pp. 542-544.

Harno, H, Kallela, M, Kaprio, J, Sippola, H, Kaunisto, MA, Palotie, A, Wessman, M, Farkkila, M 2005, 'Migraine subtype aggregation in migraine twin families with and without aura', Cephalalgia, vol 25, pp. 675-675.

Heinonen-Guzejev, M, Vuorinen, HS, Mussalo-Rauhamaa, H, Heikkilä, K, Koskenvuo, M, Kaprio, J 2005, 'Genetic component of noise sensitivity', Twin Research and Human Genetics, vol 8, no. 3, pp. 245-249.

Hennah, W, Tuulio-Henriksson, A, Paunio, T, Ekelund, J, Varilo, T, Partonen, T, Cannon, T, Lönnqvist, J, Peltonen, L 2005, 'A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia', Molecular Psychiatry, vol 10, pp. 1097-1103.

Hiekkalinna, T, Terwilliger, JD, Sammalisto, S, Peltonen, L, Perola, M 2005, 'AUTOGSCAN: Powerful tools for automated genome-wide linkage and linkage disequilibrium analysis', Twin Research and Human Genetics, vol 8, pp. 16-21.

Hirvonen, J, van Erp, TGM, Huttunen, J, Aalto, S, Någren, K, Huttunen, M, Lönnqvist, J, Kaprio, J, Hietala, J, Cannon, TD 2005, 'Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia', Archives of General Psychiatry, vol 62, no. 4, pp. 371-378.

Hiukka, A, Fruchart-Najub, J, Leinonen, E, Hilden, H, Fruchart, J, Taskinen, M 2005, 'Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes', Diabetologia, vol 48, pp. 1207-1215.

Holmqvist, J, Almgren, P, Parikh, H, Zucchelli, M, Kere, J, Groop, L, Lindgren, CM 2005, 'Haplotype construction of the FRDA gene and evaluation of its role in type II diabetes', European Journal of Human Genetics, vol 13, no. 7, pp. 849-855.

Hämäläinen, J, Poikolainen, K, Isometsä, E, Kaprio, J, Heikkinen, M, Lindeman, S, Aro, H 2005, 'Major depressive episode related to long unemployment and frequent alcohol intoxication', Nordic Journal of Psychiatry, vol 59, no. 6, pp. 486-491.

Islam, MS, Raitakari, OT, Juonala, M, Kähönen, M, Hutri-Kähönen, N, Collings, A, Aalto-Setälä, K, Kontula, K, Marniemi, J, Viikari, JSA, Lehtimäki, T 2005, 'Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms and their association with carotid artery intima-media thickness in the Finnish population: the Cardiovascular Risk in Young Finns Study', Atherosclerosis, vol 180, no. 1, pp. 79-86.

Jalanko, A, Vesa, J, Manninen, T, von Schantz, C, Minye, H, Fabritius, AL, Salonen, T, Rapola, J, Gentile, M, Kopra, O, Palotie, L 2005, 'Mice with Ppt1(Delta ex4) mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons', Neurobiology of Disease, vol 18, pp. 226-241.

CompDisGen/Kaprio

5



Jiao, H, Dahlman, I, Eriksson, P, Kere, J, Arner, P 2005, 'A common beta(2)-adrenoceptor gene haplotype protects against obesity in Swedish women', Obesity, vol 2005, no. 13, pp. 1645-1650.

Johanson, EH, Jansson, P, Gustafson, B, Sandqvist, M, Taskinen, M, Smith, U, Axelsen, M 2005, 'No acute effect of nateglinide on postprandial lipid and lipoprotein responses in subjects at risk for type 2 diabetes', Diabetes - Metabolism: Research and Reviews (Print Edition), vol 21, pp. 376-381.

Järvenpää, T, Rinne, JO, Koskenvuo, M, Räihä, I, Kaprio, J 2005, 'Binge drinking in midlife and dementia risk', Epidemiology, vol 16, no. 6, pp. 766-771.

Jörgensen, L, Hammar, N, Kaprio, J, Koskenvuo, M, Svensson, Å 2005, 'Migration and smoking: An epidemiological study of Finnish twins in Sweden', Scandinavian Journal of Public Health, vol 33, no. 4, pp. 285-291.

Kahri, J, Rapola, J 2005, 'Cardiovascular disorders in dental practice', Tandlægebladet : Dansk tandlægeforenings medlemsblad, vol 109, pp. 132-140.

Kahri, J, Valkonen, M, Bäcklund, T, Vuoristo, M, Kivistö, KT 2005, 'Rhabdomyolysis in a patient receiving atorvastatin and fluconazole', European Journal of Clinical Pharmacology, vol 60, pp. 905-907.

Kallela, M 2005, 'Mitä uutta migreenin patofysiologiasta ja genetiikasta?', Duodecim, vol 121, no. 6, pp. 665-674.

Kariola, R, Abdel-Rahman, WM, Ollikainen, M, Butzow, R, Peltomäki, P, Nyström, M 2005, 'APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers', Familial Cancer, vol 4, no. 2, pp. 187-190.

Karlsgodt, KH, van Erp, T, Therman, S, Hiltunen, J, Hari, R, Manninen, M, Huttunen, MO, Lonnqvist, J, Kaprio, J, Cannon, TD 2005, 'Diffusion tensor imaging of frontal lobe white matter in patients with schizophrenia, their healthy twins, and control subjects', Schizophrenia bulletin, vol 31, pp. 393-394.

Katoh, S, Lehtovirta, M, Kaprio, J, Harjutsalo, V, Koskenvuo, M, Eriksson, J, Tajima, N, Tuomilehto, J 2005, 'Genetic and environmental effects on fasting and postchallenge plasma glucose and serum insulin values in Finnish twins', Journal of Clinical Endocrinology and Metabolism, vol 90, no. 5, pp. 2642-2647.

Kaunisto, MA, Tikka, PJ, Kallela, M, Leal, S, Papp, JC, Korhonen, A, Hämäläinen, E, Harno, H, Havanka, H, Nissilä, M, Säkö, E, Ilmavirta, M, Kaprio, J, Färkkilä, M, Ophoff, RA, Palotie, A, Wessman, M 2005, 'Chromosome 19p13 loci in Finnish migraine with aura families', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 132B, no. 1, pp. 85-89.

Kauppinen, T, Koskela, A, Diemling, M, Keski-Rahkonen, A, Sihvola, E, Ahonen, A 2005, 'Comparison of manual and automated quantification methods of 123I-ADAM', Nuklearmedizin, vol 44, no. 5, pp. 205-212.

Kauppinen, T, Koskela, A, Diemling, M, Keski-Rahkonen, A, Sihvola, E, Ahonen, A 2005, 'Comparison of manual and automated quantification methods of I-123-ADAM', Nuklearmedizin, vol 44, no. 5, pp. 205-212.

Keech, AC, Simes, RJ, Barter, P, Best, J, Scott, R, Taskinen, M, Forder, P, Pillai, A, Davis, T, Glasziou, P, Drury, P, Kesäniemi, YA 2005, 'Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial', Lancet, vol 366, pp. 1849-1861.

Kere, J 2005, 'Mapping and identifying genes for asthma for psoriasis', Genetics of Autoimmunity, vol 2005, no. 267, pp. 46-52.

Kere, J 2005, 'Mapping and identifying genes for asthma and psoriasis', Philosophical Transactions of the Royal Society. Biological Sciences, vol 2005, no. 360, pp. 1551-1561.

Keski-Rahkonen, A, Neale, BM, Bulik, CM, Pietiläinen, K, Rose, RJ, Kaprio, J, Rissanen, A 2005, 'Intentional weight loss in young adults: Sex-specific genetic and environmental effects', Obesity, vol 13, no. 4, pp. 745-753.

Keski-Rahkonen, A, Tozzi, F 2005, 'The process of recovery in eating disorder sufferers' own words: An Internet-based study', International Journal of Eating Disorders, vol 37, pp. 80-86.

Keski-Rahkonen, A, Bulik, CM, Neale, BM, Rose, RJ, Rissanen, A, Kaprio, J 2005, 'Body dissatisfaction and drive for thinness in young adult twins', International Journal of Eating Disorders, vol 37, no. 3, pp. 188-199.

Kieseppä, T, Tuulio-Henriksson, A, Haukka, J, Van Erp, T, Glahn, D, Cannon, TD, Partonen, T, Kaprio, J, Lönnqvist, J 2005, 'Memory and verbal learning functions in twins with bipolar-I disorder, and the role of information-processing speed', Psychological Medicine, vol 35, no. 2, pp. 205-215.

Kiialainen, A, Hovanes, K, Paloneva, J, Kopra, O, Palotie, L 2005, 'Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS', Neurobiology of Disease, vol 18, pp. 314-322.

Kinnunen, S, Bonache, S, Casals, T, Monto, S, Savilahti, E, Kere, J, Järvelä, IE, Järvinen, I 2005, 'Spectrum of mutations in CFTR in Finland: 18 years follow-up study and identification of two novel mutations', Journal of Cystic Fibrosis, vol 4, no. 4, pp. 233-237.

Kinnunen, M, Kokkonen, M, Kaprio, J, Pulkkinen, L 2005, 'The associations of emotion regulation and dysregulation with the metabolic syndrome factor', Journal of Psychosomatic Research, vol 58, no. 6, pp. 513-521.

Kinnunen, M, Kaprio, J, Pulkkinen, L 2005, 'Allostatic load of men and women in early middle age', Journal of Individual Differences, vol 26, no. 1, pp. 20-28.

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Klunemann, HH, Ridha, H, Magy, L, Wherrett, JR, Hemelsoet, DM, Keen, RW, De Bleecker, JL, Rossor, MN, Marienhagen, J, Klein, HE, Peltonen, L, Paloneva, J 2005, 'The genetic causes of basal ganglia calcification, dementia, and bone cysts DAP12 and TREM2', Neurology, vol 64, pp. 1502-1507.

Koillinen, H, Lahermo, P, Rautio, J, Hukki, J, Peyrard-Janvid, M, Kere, J 2005, 'A genome-wide scan of non-syndromic cleft palate only (CPO) in Finnish multiplex families', Journal of Medical Genetics, vol 42, no. 2, pp. 177-184.

Koivumaa-Honkanen, H, Kaprio, J, Honkanen, RJ, Viinamäki, H, Koskenvuo, M 2005, 'The stability of life satisfaction in a 15-year follow-up of adult Finns healthy at baseline', BMC Psychiatry, vol 5, no. 4.

Kontula, K 2005, 'Supisuomalaiset sydäntautigeenit: Äyräpään luento 2005', Duodecim, vol 121, pp. 2665-2679.

Kontula, K, Laitinen, PJ, Lehtonen, A, Toivonen, L, Viitasalo, M, Swan, H 2005, 'Catecholaminergic polymorphic ventricular tachycardia: recent mechanistic insights', Cardiovascular Research, vol 67, pp. 379-387.

Korhonen, T, Kinnunen, T, Quiles, Z, Leeman, R, Medaglia, D, Garvey, A 2005, 'Cardiovascular Risk Behavior among Sedentary Female Smokers and Smoking Cessation Outcomes', Tobacco Induced Diseases, no. 3, pp. 7-26.

Kujala, UM, Sarna, S, Kaprio, J 2005, 'Cumulative incidence of achilles tendon rupture and tendinopathy in male former elite athletes', Clinical Journal of Sport Medicine, vol 15, no. 3, pp. 133-135.

Kujala, M, Tienari, J, Lohi, H, Elomaa, O, Sariola, H, Lehtonen, E, Kere, J 2005, 'SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney', Nephron Experimental Nephrology, vol 101, no. 2, pp. e50-e58.

Kwasnicka-Crawford, DA, Carson, AR, Roberts, W, Summers, AM, Rehnström, K, Järvelä, I, Scherer, SW 2005, 'Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay', Genomics, vol 86, no. 2, pp. 182-194.

Lahti, J, Räikkönen, K, Ekelund, J, Peltonen, L, Raitakari, OT, Keltikangas-Järvinen, L 2005, 'Novelty seeking: interaction between parental alcohol use and dopamine D4 receptor gene exon III polymorphism over 17 years', Psychiatric Genetics, vol 15, no. 2, pp. 133-139.

Lehtovirta, M, Kaprio, J, Groop, LC, Trombetta, M, Bonadonna, RC 2005, 'Heritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins', Diabetologia, vol 48, no. 8, pp. 1604-1613.

Leinonen, R, Kaprio, J, Jylhä, M, Tolvanen, A, Koskenvuo, M, Heikkinen, E, Rantanen, T 2005, 'Genetic influences underlying self-rated health in older female twins', Journal of the American Geriatrics Society, vol 53, no. 6, pp. 1002-1007.

Liljeström, B, Aktan-Collan, K, Isomaa, B, Sarelin, L, Uutela, A, Groop, L, Kääriäinen, H, Tuomi, T 2005, 'Genetic testing for maturity onset diabetes of the young: uptake, attitudes and comparison with hereditary non-polyposis colorectal cancer', Diabetologia, vol 48, pp. 242-250.

Lincoln, MR, Montpetit, A, Cader, ZM, Saarela, J, Dyment, DA, Tiislar, M, Ferretti, V, Tienari, PJ, Sadovnik, AD, Peltonen, L, Ebers, GC, Hudson, TJ 2005, 'A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis: [letters]', Nature Genetics, vol 37, no. 10, pp. 1108-1112.

Lind, S, Jiao, H, Lindgren, CM, Eriksson, M, Eggertsen, G, Kere, J, Angelin, B 2005, 'Genetic characterization of familial hypercholesterolemia in Sweden', Clinica Chimica Acta, vol 355, pp. S92-S92.

Lohi, H, Young, EJ, Fitzmaurice, SN, Rusbridge, C, Chan, EM, Vervoort, M, Turnbull, J, Zhao, XC, Ianzano, L, Paterson, AD, Sutter, NB, Ostrander, EA, Andre, C, Shelton, GD, Ackerley, CA, Scherer, SW, Minassian, BA 2005, 'Expanded repeat in canine epilepsy', Statistical Science, vol 307, pp. 81-81.

Lundbom, JJ, Vuori, K, Gaily, E, Granström, M, Blomstedt, GC, Häkkinen, A, Heikkinen, S, Lundbom, N 2005, 'Metabolite phantom correction of the nonuniform volume-selection profiles in MR spectroscopic imaging: application to temporal lobe epilepsy', American Journal of Neuroradiology, vol 2005, no. 26, pp. 1072-1077.

Lyssenko, V, Almgren, P, Anevski, D, Perfekt, R, Lahti, K, Nissen, M, Isomaa, B, Forsen, B, Holmström, N, Saloranta, C, Taskinen, M, Groop, L, Tuomi, T 2005, 'Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes', Diabetes, vol 54, pp. 166-174.

Matikainen, MP, Seppala, EH, Mononen, N, Ikonen, T, Ellonen, P, Saharinen, J, Saarinen, J, Autio, V, Tammela, TLJ, Schleutker, J 2005, 'Profiling multigenetic variation in androgen pathway as a risk factor for prostate cancer', International journal of urology., vol 173, pp. 66-67.

Mee, L, Honkala, H, Kopra, O, Vesa, J, Finnilä, S, Visapää, I, Sang, T, Jackson, GR, Salonen, R, Kestilä, M, Peltonen, L 2005, 'Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1', Human Molecular Genetics, vol 14, no. 11, pp. 1475-1488.

Melen, E, Bruce, S, Kabesch, M, Laitinen, T, Lauener, R, Lindgren, CM, Riedler, J, Scheyjius, A, van Hage-Hamsten, M, Kere, J, Pershagen, G, Wickman, M, Nyberg, F 2005, 'Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma', American Journal of Respiratory and Critical Care Medicine, vol 171, no. 10, pp. 1089-1095.

Mendiratta, ML, Vyse, TJ, Lindgren, C, Kere, J, Hudson, TJ, Nashi, E, Ge, B 2005, 'A haplotype association analysis in UK families indicates that variation at the 3 ' end of PDCD1 increases risk of SLE', Annals of the Rheumatic Diseases, vol 64, pp. 79-79.

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Mikkelsson, L, Kaprio, J, Kautiainen, H, Nupponen, H, Tikkanen, MJ, Kujala, UM 2005, 'Endurance running ability at adolescence as a predictor of blood pressure levels and hypertension in men: a 25-year follow-up study', International Journal of Sports Medicine, vol 26, no. 6, pp. 448-452.

Mikkelsson, L, Kaprio, J, Kautiainen, H, Kujala, UM, Nupponen, H 2005, 'Associations between self-estimated and measured physical fitness among 40-year-old men and women', Scandinavian Journal of Medicine & Science in Sports, vol 15, no. 5, pp. 329-335.

Mäkelä, S, Eklund, R, Lähdetie, J, Mikkola, M, Hovatta, O, Kere, J 2005, 'Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure', Molecular Human Reproduction, vol 11, no. 2, pp. 129-132.

Mäkinen, V, Parkkonen, M, Wessman, M, Groop, P, Kanninen, T, Kaski, K 2005, 'High-throughput pedigree drawing', European Journal of Human Genetics, vol 13, pp. 987-989.

Naukkarinen, J, Gentile, M, Soro-Paavonen, A, Saarela, J, Pajukanta, P, Taskinen, M, Peltonen, L, Koistinen, H 2005, 'USF1 and dyslipidemias: converging evidence for a functional intronic variant', Human Molecular Genetics, vol 14, no. 17, pp. 2595-2605.

Nikali, K, Suomalainen, AE, Saharinen, J, Kuokkanen, M, Spelbrink, JN, Lönnqvist, T, Peltonen, L 2005, 'Infantile onset spinocerebellar ataxia is caused by recessive mutations in mitochondrial proteins Twinkle and Twinky', Human Molecular Genetics, vol 14, no. 20, pp. 2981-2990.

Nowak, M, Hellebid-Chapman, A, Jakel, H, Martin, G, Duran-Sandoval, D, Staels, B, Rubin, EM, Pennaccio, LA, Taskinen, M, Fruchart-Najib, J, Fruchart, J 2005, 'Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the phosphatidylinositol 3-kinase pathway: role of upstream stimulatory factor', Molecular and Cellular Biology, vol 25, no. 4, pp. 1537-1548.

Ollikainen, M, Abdel-Rahman, WM, Moisio, A, Lindroos, A, Kariola, R, Järvelä, I, Pöyhönen, MH, Butzow, R, Peltomäki, P 2005, 'Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome?', Journal of Clinical Oncology, vol 23, no. 21, pp. 4609-4616.

Pagan, JL, Rose, RJ, Viken, RJ, Pulkkinen, L, Kaprio, J, Dick, DM 2005, 'Risk factors contributing to stages of alcohol use across adolescence and into young adulthood', Behavior Genetics, vol 35, pp. 816-817.

Pajala, S, Era, P, Koskenvuo, M, Kaprio, J, Alen, M, Tolvanen, A, Tiainen, K, Rantanen, T 2005, 'Contribution of genetic and environmental factors to individual differences in maximal walking speed with and without second task in older women', Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, vol 60, no. 10, pp. 1299-1303.

Pajusola, K, Kunnapuu, J, Vuorikoski, S, Soronen, J, Andre, H, Pereira, T, Korpisalo, P, Ylä-Herttuala, S, Poellinger, L, Alitalo, K 2005, 'Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer', FASEB Journal, vol 19, no. 10, pp. 1365-1367.

Pakkasjärvi, N, Gentile, M, Saharinen, J, Honkanen, J, Herva, R, Peltonen, L, Kestilä, M 2005, 'Indicative oligodendrocyte dysfunction in spinal cords of human fetuses suffering from a lethal motoneuron disease', Journal of neurobiology, vol 65, no. 3, pp. 269-281.

Penninkilampi-Kerola, VS, Moilanen, I, Kaprio, J 2005, 'Co-twin dependence, social interactions, and academic achievement: a population-based study', Journal of Social and Personal Relationships, vol 22, no. 4, pp. 519-541.

Penninkilampi-Kerola, V, Kaprio, J, Moilanen, I, Rose, RJ 2005, 'Co-twin dependence modifies heritability of abstinence and alcohol use: a population-based study of Finnish twins', Twin Research and Human Genetics, vol 8, no. 3, pp. 232-244.

Pertogijs, E, Sipilä, S, Alen, M, Kaprio, J, Koskenvuo, M, Tiainen, K, Rantanen, T 2005, 'Leg extension power asymmetry and mobility limitation in healthy older women', Archives of Physical Medicine and Rehabilitation , vol 86, no. 9, pp. 1838-1842.

Peyrard-Janvid, M, Pegelow, M, Koillinen, H, Larsson, C, Rautio, J, Hukki, J, Larson, O, Karsten, A, Kere, J 2005, 'Novel and de novo mutations of the IRF6 gene detected in patients with Van der Woude or popliteal pterygium syndrome', European Journal of Human Genetics, vol 13, no. 12, pp. 1261-1267.

Pierik, M, Yang, H, Barmada, MM, Cavanaugh, JA, Annese, V, Brant, SR, Cho, JH, Duerr, RH, Hugot, J, McGovern, DP, Paavola-Sakki, P, Radford-Smith, GL, Pavli, P, Siverberg, MS, Schreiber, S, Taylor, KD, Vlietinck, R, Kontula, K 2005, 'The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction', Inflammatory Bowel Diseases, vol 11, pp. 1-7.

Pietiläinen, KH, Rissanen, A, Kaprio, J, Mäkimattila, S, Häkkinen, A, Westerbacka, J, Sutinen, J, Vehkavaara, S, Yki-Järvinen, H, Pietiläinen, KH 2005, 'Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins', American Journal of Physiology: Endocrinology and Metabolism, vol 288, no. 4, pp. E768-774.

Pirkola, T, Tuulio-Henriksson, A, Glahn, D, Kieseppä, T, Haukka, J, Kaprio, J, Lönnqvist, J, Cannon, TD 2005, 'Spatial working memory function in twins with schizophrenia and bipolar disorder', Biological Psychiatry, vol 58, no. 12, pp. 930-936.

Pulkkinen, J, Häkkinen, A, Lundbom, N, Paetau, A, Kauppinen, RA, Hiltunen, Y 2005, 'Independent component analysis to proton spectroscopic imaging data of human brain tumours', European Journal of Radiology, vol 56, no. 2, pp. 160-164.

Pykäläinen, M, Kinos, R, Valkonen, S, Rydman, P, Kilpeläinen, M, Laitinen, LA, Karjalainen, J, Nieminen, M, Hurme, M, Kere, J, Laitinen, T, Lahesmaa, R 2005, 'Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes', Journal of Allergy and Clinical Immunology, vol 115, no. 1, pp. 80-87.

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Raevaara, T, Korhonen, MK, Lohi, H, Hampel, H, Lynch, E, Lönnqvist, KE, Holinski-Feder, E, Sutter, C, McKinnon, W, Duraisamy, S, Gerdes, A, Peltomäki, P, Kohonen-Corish, M, Mangold, E, Macrae, F, Greenblatt, M, Chapelle, ADL, Nyström, M, Korhonen, M 2005, 'Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1', Gastroenterology, vol 129, no. 2, pp. 537-549.

Rautanen, A, Zucchelli, M, Mäkelä, S, Kere, J 2005, 'Gene mapping with pooled samples on three genotyping platforms', Molecular and Cellular Probes, vol 19, no. 6, pp. 408-416.

Riise Stensland, HMF, Saarela, J, Bronnikov, DO, Parkkonen, M, Jokiaho, AJ, Palotie, A, Tienari, PJ, Sumelahti, M, Elovaara, I, Koivisto, K, Pirttilä, T, Reunanen, M, Sobel, E, Peltonen, L 2005, 'Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12', Journal of Neuroimmunology, vol 170, no. 1-2, pp. 122-133.

Saccone, S, Agrawal, A, Pergadia, M, Dick, D, Todorov, A, Loukola, A, Broms, U, Maunu, H, Widen, E, Heikkila, K, Rice, J, Montgomery, G, Martin, N, Kaprio, J, Palotie, L, Madden, P 2005, 'Genome-wide genetic linkage analysis of a quantitative trait in an Australian and Finnish study of nicotine dependence', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 138B, pp. 16-16.

Sammalisto, S, Hiekkalinna, T, Suviolahti, E, Sood, K, Metzidis, A, Pajukanta, P, Lilja, HE, Soro-Paavonen, A, Taskinen, M, Tuomi, T, Almgren, P, Orho-Melander, M, Groop, L, Peltonen, L, Perola, M, Tuomi, T 2005, 'A male-specific quantitative trait locus on 1p21 controlling human stature', Journal of Medical Genetics, vol 42, pp. 932-939.

Sankelo, M, Flanagan, JA, Machado, RD, Harrison, RE, Rudarakanchana, N, Morrell, NW, Dixon, M, Halme, M, Puolijoki, H, Kere, J, Elomaa, O, Kupari, M, Räisänen-Sokolowski, A, Trembath, RC, Laitinen, T 2005, 'BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension', Human Mutation, vol 26, no. 2, pp. 119-124.

Schalin-Jäntti, C, Laine, T, Valli-Jaakola, KM, Lönnqvist, T, Kontula, K, Välimäki, MJ 2005, 'Manifestation, management and molecular analysis of candidate genes in two rare cases of thyrotoxic hypokalemic periodic paralysis', Hormone Research, vol 63, pp. 139-144.

Schumacher, J, Dahdouh, F, Hilmer, AM, Koenig, IR, Anthoni, H, Zucchelli, M, Plume, E, Warnke, A, Remschmidt, H, Lindgren, CM, Propping, P, Ziegler, A, Peyrard-Janvid, M, Kere, J, Schulte-Korne, G, Nothen, MM 2005, 'Independent evidence for the VMP/DCDC2/KAAG1 gene locus on chromosomal region 6p22 as susceptibility factor for dyslexia', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 138B, pp. 114-114.

Scott, R, Best, J, Forder, P, Taskinen, M, Simes, J, Barter, P, Keech, AC 2005, 'Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481]', Cardiovascular Diabetology, no. 4, 13 s.

Shi, T, Seligson, D, Belldegrun, AS, Palotie, A, Horvath, S 2005, 'Tumor classification by tissue microarray profiling: random forest clustering applied to renal cell carcinoma', Modern Pathology, vol 18, no. 4, pp. 547-557.

Sigurdsson, S, Nordmark, G, Göring, HHH, Lindroos, K, Wiman, A, Sturfelt, G, Jönsen, A, Rantapää-Dahlqvist, S, Möller, B, Kere, J, Koskenmies, S, Widen, E, Eloranta, M, Julkunen, H, Kristjansdottir, H, Steinsson, K, Alm, G, Rönnblom, L, Syvänen, A 2005, 'Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus', American Journal of Human Genetics, vol 76, no. 3, pp. 528-537.

Silander, K, Komulainen, K, Ellonen, P, Jussila, M, Alanne, M, Levander, M, Tainola, P, Kuulasmaa, K, Salomaa, V, Perola, M, Peltonen, L, Saarela, J 2005, 'Evaluating whole genome amplification via multiply-primed rolling circle amplification for SNP genotyping of samples with low DNA yield', Twin Research and Human Genetics, vol 8, pp. 368-375.

Silventoinen, K, Kaprio, J 2005, 'Geenit, ympäristö ja älykkyys', Duodecim, vol 121, no. 2, pp. 125-126.

Swan, H, Laitinen, P, Kontula, K, Toivonen, L 2005, 'Calcium channel antagonism reduces exercise-induced ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia patients with RyR2 mutations', Journal of Cardiovascular Electrophysiology, vol 16, pp. 162-166.

Swanberg, M, Lidman, O, Padyukov, L, Eriksson, P, Akesson, E, Jagodic, M, Lobell, A, Khademi, M, Borjesson, O, Lindgren, CM, Lundman, P, Brookes, AJ, Kere, J, Luthman, H, Alfredsson, L, Hillert, J, Klareskog, L, Hamsten, A, Piehl, F, Olsson, T 2005, 'MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction', Nature Genetics, vol 2005, no. 37, pp. 486-494.

Söderlund, S, Soro-Paavonen, A, Ehnholm, C, Jauhiainen, M, Taskinen, M 2005, 'Hypertriglyceridemia is associated with prebeta-HDL concentrations in subjects with familial low HDL', Journal of Lipid Research, vol 46, pp. 1643-1651.

Sørensen, TIA, Rissanen, A, Korkeila, M, Kaprio, J 2005, 'Intention to lose weight, weight changes, and 18-y mortality in overweight individuals without co-morbidities', PLoS Medicine, vol 2, no. 6, pp. 510-520.

Taskinen, M 2005, 'Type 2 diabetes as a lipid disorder', Current Molecular Medicine, vol 5, pp. 297-308.

Thorn, LM, Forsblom, C, Fagerudd, J, Thomas, MC, Pettersson-Fernholm, K, Saraheimo, M, Waden, J, Rönnback, M, Rosengård-Bärlund, M, Björkesten, CA, Taskinen, M, Groop, P 2005, 'Metabolic syndrome in type 1 diabetes: association with diabetic nephropathy and glycemic control (the FinnDiane study)', Diabetes Care, vol 28, pp. 2019-2024.

Tiainen, K, Sipilä, S, Alen, M, Heikkinen, E, Kaprio, J, Koskenvuo, M, Tolvanen, A, Pajala, S, Rantanen, T 2005, 'Shared genetic and environmental effects on strength and power in older female twins', Medicine and Science in Sports and Exercise, vol 37, no. 1, pp. 72-78.

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Tikkanen, HO, Waden, J, Forsblom, C, Fagerudd, J, Pettersson-Fernholm, K, Tikkanen, H, Wessman, M, Parkkonen, M, Frojdo, S, Lakka, T, Groop, PH 2005, 'The PPAR gamma Pro12Ala polymorphism may influence the association of physical activity with lipid profile, insulin sensitivity and glycemic control in type 1 diabetes', Diabetologia, vol 48, pp. A254-A255.

Timonen, M, Kankaanranta, L, Lundbom, N, Collan, J, Kangasmäki, A, Kortesniemi, M, Häkkinen, A, Lönngren, A, Karjalainen, S, Rasilainen, M, Leinonen, J, Huitti, T, Jääskeläinen, J, Kouri, M, Savolainen, S, Heikkinen, S 2005, '¹H MRS studies in the Finnish boron neutron capture therapy project: Detection of 10B-carrier, L-p-boronophenylalanine-fructose', European Journal of Radiology, vol 56, no. 2, pp. 154-159.

Tuomi, T 2005, 'Type 1 and type 2 diabetes: what do they have in common?', Diabetes, vol 54, no. S2, pp. S40-S45.

Veal, CD, Reynolds, NJ, Meggitt, SJ, Allen, MH, Lindgren, CM, Kere, J, Trembath, RC, Barker, J, Lindgren, C 2005, 'Absence of association between asthma and high serum immunoglobulin E associated GPRA haplotypes and adult atopic dermatitis', Journal of Investigative Dermatology, vol 125, no. 2, pp. 399-401.

Veal, C, Lindgren, CM, Allen, MH, Meggitt, SJ, Trembath, RC, Reynolds, NJ, Kere, J, Barker, JNWN 2005, 'Analysis of asthma and high serum IgE associated haplotypes in atopic dermatitis (AD)', British Journal of Dermatology, vol 152, pp. 850-850.

Vendelin, J, Pulkkinen, V, Rehn, M, Pirskanen, A, Räisänen-Sokolowski, A, Laitinen, A, Laitinen, LA, Kere, J, Laitinen, T 2005, 'Characterization of GPRA, a novel G protein-coupled receptor related to asthma', American Journal of Respiratory Cell and Molecular Biology, vol 33, no. 3, pp. 262-270.

Verkasalo, PK, Lillberg, K, Stevens, RG, Hublin, C, Partinen, M, Koskenvuo, M, Kaprio, J 2005, 'Sleep duration and breast cancer: A prospective cohort study', Cancer Research, vol 65, no. 20, pp. 9595-9600.

Viitasalo, M, Paavonen, KJ, Swan, H, Kontula, K, Toivonen, L 2005, 'Effects of epinephrine on right ventricular monophasic action potentials in the LQT1 versus LQT2 form of long QT syndrome: preferential enhancement of "triangulation" in LQT1', Pacing and Clinical Electrophysiology, vol 28, pp. 219-227.

Välimäki, V, Piippo, K, Välimäki, S, Löyttyniemi, E, Kontula, K, Välimäki, MJ 2005, 'The relation of the XbaI and PvuII polymorphisms of the estrogen receptor gene and the CAG repeat polymorphism of the androgen receptor gene to peak bone mass and bone turnover rate among young healthy men', Osteoporosis International, vol 16, pp. 1633-1640.

Westerbacka, J, Leinonen, E, Salonen, JT, Salonen, R, Hiukka, A, Yki-Järvinen, H, Taskinen, M 2005, 'Increased augmentation of central blood pressure is associated with increases in carotid intima-media thickness in type 2 diabetic patients', Diabetologia, vol 48, pp. 1654-1662.

Winckler, W, Burtt, NP, Holmkvist, J, Cervin, C, de Bakker, PIW, Sun, M, Almgren, P, Tuomi, T, Gaudet, D, Hudson, TJ, Ardlie, KG, Daly, MJ, Hirschhorn, JN, Altshuler, D, Groop, L 2005, 'Association testing of variants in the hepatocyte nuclear factor 4alpha gene with risk of type 2 diabetes in 7,883 people', Diabetes, vol 54, pp. 2336-2342.

Winckler, W, Burtt, NP, Holmkvist, J, Cervin, C, de Bakker, PIW, Sun, M, Almgren, P, Tuomi, T, Gaudet, D, Hudson, TJ, Ardlie, KG, Daly, MJ, Hirschhorn, JN, Altshuler, D, Groop, L 2005, 'Association of common variation in the HNF1 alpha gene region with risk of type 2 diabetes', Diabetes, vol 54, pp. 2336-2342.

Wu, H, Cantor, RM, Cunningham Graham, DS, Lindgren, CM, Farwell, L, De Jager, PL, Bottini, N, Grossman, JM, Wallace, DJ, Hahn, BH, Julkunen, H, Hebert, LA, Rovin, BH, Birmingham, DJ, Rioux, JD, Yu, CY, Kere, J, Vyse, TJ, Tsao, BP 2005, 'Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease', Arthritis & Rheumatism, vol 52, no. 8, pp. 2396-2402.

Ylisaukko-oja, T, Rehnström, K, Auranen, M, Vanhala, R, Alen, R, Kempas, E, Ellonen, P, Turunen, JA, Makkonen, I, Riikonen, R, Nieminen-von Wendt, T, Wendt, LV, Peltonen, L, Järvelä, I 2005, 'Analysis of four neuroligin genes as candidates for autism', European Journal of Human Genetics, vol 13, no. 12, pp. 1285-1292.

Ylisaukko-oja, T, Peyrard-Janvid, M, Lindgren, CM, Rehnström, K, Vanhala, R, Peltonen, L, Järvelä, I, Kere, J 2005, 'Family-based association study of DYX1C1 variants in autism', European Journal of Human Genetics, vol 13, no. 1, pp. 127-130.

Ylisaukko-oja, T, Rehnström, K, Vanhala, R, Kempas, E, Koskull, HV, Tengström, C, Mustonen, A, Ounap, K, Lähdetie, J, Järvelä, I 2005, 'MECP2 mutation analysis in patients with mental retardation', American Journal of Medical Genetics. Part A, vol 132A, no. 2, pp. 121-124.

Ylisaukko-oja, T, Varilo, T, Kilpinen, H, Alen, R, Vanhala, R, Kempas, E, Elmohandness, M, von Wendt, L, Jarvela, I, Peltonen, L 2005, 'Genome-wide scan for autism in an extended pedigree from a regional subisolate in Finland', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 138B, pp. 72-72.

2006 Adiels, M, Taskinen, M, Packard, C, Caslake, MJ, Soro-Paavonen, A, Westerbacka, J, Vehkavaara, S, Häkkinen, A, Olofsson, S, Yki-Järvinen, H, Boren, J 2006, 'Overproduction of large VLDL particles is driven by increased liver fat content in man', Diabetologia, vol 49, pp. 755-765.

Adiels, M, Olofsson, S, Taskinen, M, Boren, J 2006, 'Diabetic dyslipidaemia', Current Opinion in Lipidology, vol 17, pp. 238-246.

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Ahveninen, J, Jääskeläinen, I, Osipova, D, Huttunen, MO, Ilmoniemi, R, Kaprio, J, Lönnqvist, J, Manninen, M, Pakarinen, S, Therman, S, Näätänen, R, Cannon, TD 2006, 'Inherited auditory-cortical dysfunction in twin pairs discordant for schizophrenia', Biological Psychiatry, vol 60, no. 6, pp. 612-620.

Al Majali, K, Cooper, MB, Staels, B, Luc, G, Taskinen, M, Betteridge, DJ 2006, 'The effect of sensitisation to insulin with pioglitazone on fasting and postprandial lipid metabolism, lipoprotein modification by lipases, and lipid transfer activities in type 2 diabetic patients', Diabetologia, vol 49, pp. 527-537.

Anttila, V, Kallela, M, Oswell, G, Kaunisto, M, Nyholt, DR, Hämäläinen, E, Havanka, H, Ilmavirta, M, Terwilliger, J, Sobel, E, Peltonen, L, Kaprio, J, Färkkilä, M, Wessman, M, Palotie, A 2006, 'Trait components provide tools to dissect the genetic susceptibility of migraine', American Journal of Human Genetics, vol 79, no. 1, pp. 85-99.

Arajärvi, R, Varilo, T, Haukka, J, Suvisaari, J, Suokas, J, Juvonen, H, Muhonen, M, Suominen, K, Hintikka, J, Schreck, M, Tuulio-Henriksson, A, Partonen, T, Lönnqvist, J 2006, 'Affective flattening and alogia associate with the familial form of schizophrenia', Psychiatry Research, vol 141, no. 2, pp. 161-172.

Artto, V, Wessman, M, Nissilä, M, Säkö, E, Liukkonen, J, Teirmaa, H, Harno, H, Havanka, H, Ilmavirta, M, Palotie, A, Färkkilä, M, Kallela, M 2006, 'Comorbidity in Finnish migraine families', Journal of Headache and Pain, vol 7, no. 5, pp. 324-330.

Auro, K, Komulainen, M, Alanne, M, Silander, K, Peltonen, L, Perola, M, Salomaa, V 2006, 'Thrombomodulin gene polymorphisms and haplotypes and the risk of cardiovascular events: a prospective follow-up study', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 26, no. 4, pp. 942-947.

Bahr, C, Schön, S, Kuhn, J, Groop, P, Parkkonen, M, Wessman, M, Kleesiek, K, Götting, C 2006, 'Novel sequence variants in the human xylosyltransferase I gene and their role in diabetic nephropathy', Diabetic Medicine, vol 23, pp. 681-684.

Baker, SG, Kaprio, J 2006, 'Common susceptibility genes for cancer: search for the end of the rainbow', BMJ - Clinical Research Edition, vol 332, no. 7550, pp. 1150-1152.

Baker, SG, Kaprio, J 2006, 'Cancer genetics - Common susceptibility genes for cancer: search for the end of the rainbow', BMJ : British Medical Journal, vol 332, pp. 1150-1152.

Bidel, S, Hu, G, Sundvall, J, Kaprio, J, Tuomilehto, J 2006, 'Effects of coffee consumption on glucose tolerance, serum glucose and insulin levels - A cross-sectional analysis', Hormone and Metabolic Research, vol 38, no. 1, pp. 38-43.

Broms, U, Silventoinen, K, Madden, PAF, Heath, AC, Kaprio, J 2006, 'Genetic architecture of smoking behavior: A study of Finnish adult twins', Twin Research and Human Genetics, vol 9, no. 1, pp. 64-72.

Brännström, J, Hässler, S, Peltonen, L, Herrmann, B, Winqvist, O 2006, 'Defect internalization and tyrosine kinase activation in Aire deficient antigen presenting cells exposed to Candida albicans antigens', Clinical Immunology, vol 121, no. 3, pp. 265-273.

Bugyi, B, Papp, G, Hild, G, Lorinczy, D, Nevalainen, EM, Lappalainen, P, Somogyi, B, Nyitrai, M 2006, 'Formins regulate actin filament flexibility through long range allosteric interactions', Journal of Biological Chemistry, vol 281, no. 16, pp. 10727-10736.

Bäckmand, H, Kaprio, J, Kujala, UM, Sarna, S, Fogelholm, M 2006, 'Physical and psychological functioning of daily living in relation to physical activity. A longitudinal study among former elite male athletes and controls', Aging Clinical and Experimental Research, vol 18, no. 1, pp. 40-49.

Cannon, T, Thompson, P, van Erp, T, Huttunen, M, Lönnqvist, J, Kaprio, JA, Toga, A 2006, 'Mapping heritability and molecular genetic associations with cortical features using probabilistic brain atlases: methods and applications to schizophrenia', NeuroInformatics, vol 4, no. 1, pp. 5-19.

Chin, RK, Zhu, M, Christiansen, PA, Liu, W, Ware, C, Peltonen, L, Zhang, X, Guo, L, Han, S, Zheng, B, Fu, Y 2006, 'Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen', Journal of Immunology, vol 177, no. 1, pp. 290-297.

Dahlman, I, Nilsson, M, Jiao, H, Hoffstedt, J, Lindgren, CM, Humphreys, K, Kere, J, Gustafsson, J, Arner, P, Dahlman-Wright, K 2006, 'Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity', Pharmacogenetics and Genomics, vol 2006, no. 16, pp. 881-889.

De Jager, PL, Graham, R, Farwell, L, Sawcer, S, Richardson, A, Behrens, TW, Compston, A, Hafler, DA, Kere, J, Vyse, TJ, Rioux, JD 2006, 'The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus', Genes and Immunity, vol 7, no. 4, pp. 327-334.

Del Bo, R, Scarlato, M, Ghezzi, S, Maestroni, A, Sjölind, L, Forsblom, C, Wessman, M, Groop, P, Comi, GP, Bresolin, N, Luzi, L, Zerbini, G 2006, 'VEGF gene variability and type 1 diabetes: evidence for a protective role', Immunogenetics, vol 58, pp. 107-112.

Dick, DM, Rose, RJ, Kaprio, J 2006, 'The next challenge for psychiatric genetics: characterizing the risk associated with identified genes', Annals of Clinical Psychiatry, vol 18, no. 4, pp. 223-231.

Donner, K, Nowak, KJ, Aro, M, Pelin, K, Wallgren-Pettersson, C 2006, 'Developmental and muscle-type-specific expression of mouse nebulin exons 127 and 128', Genomics, vol 88, pp. 489-495.

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Ekelund, E, Sääf, A, Tengvall-Linder, M, Melen, E, Link, J, Barker, J, Reynolds, NJ, Meggitt, SJ, Kere, J, Wahlgren, C, Pershagen, G, Wickman, M, Nordenskjöld, M, Kockum, I, Bradley, M 2006, 'Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis', American Journal of Human Genetics, vol 78, no. 6, pp. 1060-1065.

Ekström Smedby, K, Lindgren, CM, Hjalgrim, H, Humhreys, K, Schöllkopf, C, Chang, ET, Roos, G, Ryder, LP, Falk, KI, Palmgren, J, Kere, J, Melbye, M, Glimelius, B, Adami, H 2006, 'Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma', Cancer Epidemiology, Biomarkers & Prevention, vol 15, no. 2, pp. 258-265.

Fagerlund, A, Heikkinen, S, Autti-Ramo, I, Korkman, M, Timonen, M, Kuusi, T, Riley, EP, Lundbom, N 2006, 'Brain metabolic alterations in adolescents and young adults with fetal alcohol spectrum disorders', Alcoholism: Clinical and Experimental Research , vol 30, no. 12, pp. 2097-2104.

Fagerudd, J, Forsblom, C, Pettersson-Fernholm, K, Saraheimo, M, Waden, J, Rönnback, M, Rosengård-Bärlund, M, Björkesten, CA, Thorn, LM, Wessman, M, Groop, P, Thorn, L, FinnDiane study group 2006, 'Low birth weight does not increase the risk of nephropathy in Finnish type 1 diabetic patients', Nephrology, Dialysis, Transplantation, vol 21, no. 8, pp. 2159-2165.

Feuk, L, Kalervo, A, Lipsanen-Nyman, M, Skaug, J, Nakabayashi, K, Finucane, B, Hartung, D, Innes, M, Kerem, B, Nowackzyk, MJ, Rivlin, J, Roberts, W, Senman, L, Summers, A, Szatmari, P, Wong, V, Vincent, JB, Zeesman, S, Osborne, LR, Cardy, JO, Kere, J, Scherer, SW, Hannula-Jouppi, K 2006, 'Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia', American Journal of Human Genetics, vol 79, pp. 965-972.

Florez, JC, Saxena, R, Winckler, W, Burtt, NP, Almgren, P, Bengtsson Boström, K, Tuomi, T, Gaudet, D, Ardlie, KG, Daly, MJ, Altshuler, D, Hirschhorn, JN, Groop, L 2006, 'The Kruppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people', Diabetes, vol 55, pp. 3620-3624.

Florez, JC, Wiltshire, S, Agapakis, CM, Burtt, NP, de Bakker, PIW, Almgren, P, Bengtsson Boström, K, Tuomi, T, Gaudet, D, Daly, MJ, Hirschhorn, JN, McCarthy, MI, Altshuler, D, Groop, L 2006, 'High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people', Diabetes, vol 55, pp. 128-135.

Fodstad, H, Bendahhou, S, Rougier, J, Laitinen-Forsblom, PJ, Barhanin, J, Abriel, H, Schild, L, Kontula, K, Swan, H 2006, 'Molecular characterization of two founder mutations causing long QT syndrome and identification of compound heterozygous patients', Annals of Medicine, vol 38, pp. 294-304.

Graner, M, James, RW, Kahri, J, Nieminen, MS, Syvänne, M, Taskinen, M 2006, 'Association of paraoxonase-1 activity and concentration with angiographic severity and extent of coronary artery disease', Journal of the American College of Cardiology, vol 47, pp. 2429-2435.

Graner, M, Varpula, M, Kahri, J, Salonen, RM, Nyyssönen, K, Nieminen, MS, Taskinen, M, Syvänne, M 2006, 'Association of carotid intima-media thickness with angiographic severity and extent of coronary artery disease', American Journal of Cardiology, vol 97, pp. 624-629.

Graner, M, Kahri, J, Nakano, T, Sarna, SJ, Nieminen, MS, Syvänne, M, Taskinen, M 2006, 'Impact of postprandial lipaemia on low-density lipoprotein (LDL) size and oxidized LDL in patients with coronary artery disease', European Journal of Clinical Investigation, vol 36, no. 11, pp. 764-770.

Groop, L, Tuomi, T, Rowley, M, Zimmet, P, Mackay, IR 2006, 'Latent autoimmune diabetes in adults (LADA) - more than a name', Diabetologia, vol 49, pp. 1996-1998.

Hannukainen, JC, Nuutila, P, Kaprio, J, Heinonen, OJ, Kujala, UM, Janatuinen, T, Rönnemaa, T, Kapanen, J, Haaparanta-Solin, M, Viljanen, T, Knuuti, J, Kalliokoski, KK 2006, 'Relationship between local perfusion and FFA uptake in human skeletal muscle - no effect of increased physical activity and aerobic fitness', Journal of Applied Physiology, vol 101, no. 5, pp. 1303-1311.

Hannukainen, J, Nuutila, P, Borra, R, Kaprio, J, Kujala, U, Janatuinen, T, Heinonen, O, Kapanen, J, Viljanen, T, Haaparanta , M, Rönnemaa, T, Parkkola, R, Knuuti, J, Kalliokoski, K 2006, 'Increased physical activity decreases hepatic free fatty acid uptake: a study in monozygotic twins', Journal of Physiology, vol 578, no. 1, pp. 347-358.

Hedlund, E, Hammar, N, Lange, A, Koskenvuo, M, Jorgensen, L, Kaprio, J 2006, 'Migrating twins: A study of welfare components among Finnish twins living in Sweden and their co-twins residing in Finland', Journal of Ethnic and Migration Studies, vol 32, pp. 3-28.

Helfer, E, Nevalainen, EM, Naumanen, P, Romero, S, Didry, D, Pantaloni, D, Lappalainen, P, Carlier, M 2006, 'Mammalian twinfilin sequesters ADP-G-actin and caps filament barbed ends: implications in motility', EMBO Journal, vol 25, pp. 1184-1195.

Hemilä, H, Virtamo, J, Albanes, D, Kaprio, J 2006, 'The effect of vitamin E on common cold incidence is modified by age, smoking and residential neighborhood', Journal of the American College of Nutrition, vol 25, no. 4, pp. 332-339.

Hemilä, H, Kaprio, J, Albanes, D, Virtamo, J 2006, 'Physical activity and the risk of pneumonia in male smokers administered vitamin E and beta-carotene', International Journal of Sports Medicine, vol 27, no. 4, pp. 336-341.

Hero, M, Ankarberg, C, Taskinen, M, Dunkel, L 2006, 'Blockade of oestrogen biosynthesis in peripubertal boys: effects on lipid metabolism, insulin sensitivity, and body composition', European Journal of Endocrinology, vol 155, pp. 453-460.

Hihnala, S, Kujala, M, Toppari, J, Kere, J, Holmberg, C, Höglund, P 2006, 'Expression of SLC26A3, CFTR and NHE3 in the human male reproductive tract: role in male subfertility caused by congenital chloride diarrhoea', Molecular Human Reproduction, vol 12, no. 2, pp. 107-111.

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Hihnala, S, Höglund, P, Lammi, L, Kokkonen, J, Örmälä, T, Holmberg, C 2006, 'Long-term clinical outcome in patients with congenital chloride diarrhea', Journal of Pediatric Gastroenterology and Nutrition, vol 42, pp. 369-375.

Hirvonen, J, van Erp, TGM, Huttunen, J, Någren, K, Huttunen, M, Aalto, S, Lönnqvist, J, Kaprio, J, Cannon, TD, Hietala, J 2006, 'Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia', Psychiatry Research: Neuroimaging, vol 146, no. 1, pp. 13-20.

Hirvonen, J, van Erp, TGM, Huttunen, J, Aalto, S, Någren, K, Huttunen, M, Lönnqvist, J, Kaprio, J, Cannon, TD, Hietala, J 2006, 'Brain dopamine d1 receptors in twins discordant for schizophrenia', American Journal of Psychiatry, vol 163, no. 10, pp. 1747-1753.

Hirvonen, J, van Erp, TGM, Huttunen, J, Aalto, S, Någren, K, Huttunen, M, Lönnqvist, J, Kaprio, J, Cannon, TD, Hietala, J 2006, 'Brain dopamine D-1 receptors in twins discordant for schizophrenia', American Journal of Psychiatry, vol 163, no. 10, pp. 1747-1753.

Hjelmborg, JV, Iachine, I, Skytthe, A, Vaupel, JW, Mcgue, M, Koskenvuo, M, Kaprio, J, Pedersen, NL, Christensen, K 2006, 'Genetic influence on human lifespan and longevity', Journal of human genetics., vol 119, no. 3, pp. 312-321.

Hodgson, U, Pulkkinen, V, Dixon, M, Peyrard-Janvid, M, Rehn, M, Lahermo, P, Ollikainen, V, Salmenkivi, K, Kinnula, V, Kere, J, Tukiainen, P, Laitinen, T 2006, 'ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis', American Journal of Human Genetics, vol 79, no. 1, pp. 149-154.

Holmkvist, J, Cervin, C, Lyssenko, V, Winckler, W, Anevski, D, Cilio, C, Almgren, P, Berglund, G, Nilsson, P, Tuomi, T, Lindgren, CM, Altshuler, D, Groop, L 2006, 'Common variants in HNF-1 alpha and risk of type 2 diabetes', Diabetologia, vol 49, pp. 2882-2891.

Holmkvist, J, Cervin, C, Lyssenko, V, Winckler, W, Anevski, D, Cilio, C, Almgren, P, Berglund, G, Nilsson, P, Tuomi, T, Lindgren, CM, Altshuler, D, Groop, L 2006, 'Common variants in HNF-1 [alpha] and risk of type 2 diabetes', Diabetologia, vol 49, pp. 2882-2891.

Hunt, MC, Rautanen, A, Westin, MAK, Svensson, LT, Alexson, SEH 2006, 'Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs', FASEB Journal, vol 20, no. 11, pp. 1855-1864.

Hässler, S, Ramsey, C, Karlsson, MC, Larsson, D, Herrmann, B, Rozell, B, Backheden, M, Peltonen, L, Kämpe, O, Winqvist, O 2006, 'Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma', Blood, vol 108, no. 6, pp. 1941-1948.

Höglund, P, Hihnala, S, Kujala, M, Tiitinen, A, Dunkel, L, Holmberg, C 2006, 'Disruption of the SLC26A3-mediated anion transport is associated with male subfertility', Fertility and Sterility : official journal of the American Fertility Society , vol 85, no. 1, pp. 232-235.

Islam, MS, Lehtimäki, T, Juonala, M, Kähönen, M, Hutri-Kähönen, N, Kainulainen, K, Miettinen, H, Taittonen, L, Kontula, K, Viikari, JSA, Raitakari, OT 2006, 'Polymorphism of the angiotensin-converting enzyme (ACE) and angiotesinogen (AGT) genes and their associations with blood pressure and carotid artery intima media thickness among healthy Finnish young adults: the Cardiovascular Risk in Young Finns Study', Atherosclerosis, vol 188, pp. 316-322.

Kahri, J, Soro-Paavonen, A, Ehnholm, C, Taskinen, M 2006, 'ApoE polymorphism is associated with C-reactive protein in low-HDL family members and in normolipidemic subjects', Mediators of Inflammation, vol 2006 (2006), 5 s.

Kaipainen, M, Broms, U, Hosia-Randell, H, Söderlund-Venermo, M, Graner, M, Heikman, P, Öistämö, H 2006, 'Viihdyttäminen opetuksessa - turhuutta vai tärkeä mauste?', Suomen lääkärilehti , vol 61, no. 4, pp. 329-334.

Kaprio, J 2006, 'Twin studies in Finland 2006', Twin Research and Human Genetics, vol 9, no. 6, pp. 772-777.

Karppinen, S, Barkardottir, RB, Backenhorn, K, Sydenham, T, Syrjäkoski, K, Schleutker, J, Ikonen, T, Pylkäs, K, Rapakko, K, Erkko, H, Johannesdottir, G, Gerdes, A, Thomassen, M, Agnarsson, BA, Grip, M, Kallioniemi, A, Kere, J, Aaltonen, LA, Arason, A, Møller, P, Kruse, TA, Borg, Å, Winqvist, R 2006, 'Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies', Journal of Medical Genetics, vol 43, no. 11, pp. 856-862.

Kaunisto, M, Kallela, KMJ, Hämäläinen, E, Kilpikari, R, Havanka, H, Harno, H, Nissilä, M, Säkö, E, Ilmavirta, M, Liukkonen, J, Teirmaa, H, Törnwall, O, Jussila, M, Terwilliger, J, Färkkilä, M, Kaprio, J, Palotie, A, Wessman, M 2006, 'Testing of variants of the MTHFR and ESR1 genes in 1798 Finnish individuals fails to confirm the association with migraine with aura', Cephalalgia, vol 26, no. 12, pp. 1462-1472.

Keski-Rahkonen, A, Sihvola, E, Raevuori, A, Kaukoranta, J, Bulik, CM, Hoek, HW, Rissanen, A, Kaprio, J 2006, 'Reliability of self-reported eating disorders: Optimizing population screening', International Journal of Eating Disorders, vol 39, no. 8, pp. 754-762.

Kettunen, JA, Kujala, UM, Kaprio, J, Sarna, S 2006, 'Health of master track and field athletes - A 16-year follow-up study', Clinical Journal of Sport Medicine, vol 16, no. 2, pp. 142-148.

Kinnunen, T, Haukkala, A, Korhonen, T, Quoles, ZN, Spiro, A, Garvey, AJ 2006, 'Depression and smoking across 25 years of the normative aging study', International Journal of Psychiatry in Medicine, vol 36, no. 4, pp. 413-426.

Komulainen, K, Alanne, M, Kilpikari, R, Pajukanta, P, Ellonen, P, Salminen, K, Kulathinal, S, Kuulasmaa, K, Silander, K, Salomaa, V, Perola, M, Peltonen, L, Saarela, J 2006, 'Risk alleles of USF1 gene predict cardiovascular disease of women in two prospective studies', PLoS Genetics, vol 2, no. 5.

Korhonen, T, Kinnunen, TH, Garvey, AJ 2006, 'Impact of nicotine replacement therapy on post-cessation mood profile by pre-cessation depressive symptoms', Tobacco Induced Diseases, vol 3, no. 2, pp. 17-33.

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Kuokkanen, M, Kokkonen, J, Enattah, NS, Ylisaukko-oja, T, Komu, H, Varilo, T, Peltonen, L, Savilahti, E, Järvelä, I, Enattah, NS, Ylisaukko-Oja, T 2006, 'Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency', American Journal of Human Genetics, vol 78, no. 2, pp. 339-344.

Kyttälä, M, Tallila, J, Salonen, R, Kopra, O, Kohlschmidt, N, Paavola-Sakki, P, Peltonen, L, Kestilä, M 2006, 'MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome', Nature Genetics, vol 38, no. 2, pp. 155-157.

Lahermo, P, Liljedahl, U, Alnaes, G, Axelsson, T, Brookes, AJ, Ellonen, P, Groop, P, Hallden, C, Holmberg, D, Holmberg, K, Keinänen, M, Kepp, K, Kere, J, Kiviluoma, P, Kristensen, V, Lindgren, CM, Odeberg, J, Osterman, P, Parkkonen, M, Saarela, J, Sterner, M, Strömqvist, L, Talas, U, Wessman, M, Palotie, A, Syvänen, A 2006, 'A quality assessment survey of SNP genotyping laboratories', Human Mutation, vol 27, no. 7, pp. 711-714.

Lahti, J, Räikkönen, K, Ekelund, J, Peltonen, L, Raitakari, OT, Keltikangas-Järvinen, L 2006, 'Socio-demographic characteristics moderate the association between DRD4 and novelty seeking', Personality and Individual Differences, vol 40, no. 3, pp. 533-543.

Laitinen-Forsblom, PJ, Mäkynen, P, Mäkynen, H, Yli-Mäyry, S, Virtanen, V, Kontula, K, Aalto-Setälä, K 2006, 'SCN5A mutation associated with cardiac conduction defectand atrial arrhythmias', Journal of Cardiovascular Electrophysiology, vol 17, pp. 480-485.

Lappalainen, T, Koivumäki, S, Salmela, E, Huoponen, K, Sistonen, P, Savontaus, M, Lahermo, P 2006, 'Regional differences among the Finns: a Y-chromosomal perspective', Gene, vol 376, no. 2, pp. 207-215.

Lappalainen, M, Paavola-Sakki, P, Halme, L, Turunen, U, Heliö, T, Färkkilä, M, Kontula, K 2006, 'Screening of tumor necrosis factor receptor-associated factor 6 as a candidate gene for inflammatory bowel disease', Scandinavian Journal of Gastroenterology, vol 41, no. 4, pp. 424-429.

Lehtokari, V, Pelin, K, Sandbacka, M, Ranta, S, Donner, K, Muntoni, F, Sewry, C, Angelini, C, Bushby, K, van den Bergh, P, Iannaccone, S, Laing, NG, Wallgren-Pettersson, C 2006, 'Identification of 45 novel mutations in the nebulin gene associated with autosomal recessive nemaline myopathy', Human Mutation, vol 27, no. 9, pp. 946-956.

Lindsberg, PJ, Häppölä, O, Kallela, M, Valanne, L, Kuisma, M, Kaste, M 2006, 'Door to thrombolysis: ER reorganization and reduced delays to acute stroke treatment', Neurology, vol 67, no. 2, pp. 334-336.

Lorentzen, AR, Smestad, C, Ekstrom, PO, Oturai, AB, Akesson, E, Saarela, J, Myhr, K, Lie, BA, Celius, EG, Sorensen, PS, Hillert, J, Spurkland, A, Harbo, HF 2006, 'The role of SH2D2A gene polymorphisms in multiple sclerosis', Multiple Sclerosis, vol 12, pp. S72-S72.

Lundmark, F, Harbo, H, Saarela, J, Oturai, A, Lindgren, C, Salter, H, Hillert, J 2006, 'CD4, a candidate gene for multiple sclerosis?', Journal of Neuroimmunology, vol 178, pp. 185-185.

Lundmark, F, Harbo, HF, Celius, EG, Saarela, J, Datta, P, Oturai, A, Lindgren, CM, Masterman, T, Salter, H, Hillert, J 2006, 'Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations', Journal of Neuroimmunology, vol 180, pp. 193-198.

Lyon, HN, Florez, JC, Bersaglieri, T, Saxena, R, Winckler, W, Almgren, P, Lindblad, U, Tuomi, T, Gaudet, D, Xiaofeng, Z, Cooper, R, Ardlie, KG, Daly, MJ, Altshuler, D, Groop, L, Hirschhorn, JN 2006, 'Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity', Diabetes, vol 55, pp. 3180-3184.

Lyssenko, V, Almgren, P, Anevski, D, Orho-Melander, M, Sjögren, M, Saloranta, C, Tuomi, T, Groop, L, Botnia Study Group 2006, 'Genetic Prediction of Future Type 2 Diabetes', PLoS Medicine, vol 2, no. 12, e345, pp. 1299-1308.

Matikainen, N, Mänttäri, S, Schweizer, A, Ulvestad, A, Mills, D, Dunning, BE, Foley, JE, Taskinen, M 2006, 'Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes', Diabetologia, vol 49, pp. 2049-2057.

Melen, E, Umerkajeff, S, Nyberg, F, Zucchelli, M, Lindstedt, A, Gullsten, H, Wickman, M, Pershagen, G, Kere, J 2006, 'Interaction between variants in the interleukin-4 receptor [alpha] and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study', Clinical and Experimental Allergy, vol 36, no. 11, pp. 1391-1398.

Mikkelsson, LO, Nupponen, H, Kaprio, J, Kautiainen, H, Mikkelsson, M, Kujala, UM 2006, 'Adolescent flexibility, endurance strength, and physical activity as predictors of adult tension neck, low back pain, and knee injury: a 25 year follow up study', British Journal of Sports Medicine, vol 40, no. 2, pp. 107-113.

Mikkelsson, L, Kaprio, J, Kautiainen, H, Kujala, U, Mikkelsson, M, Nupponen, H 2006, 'School fitness tests as predictors of adult health-related fitness', American Journal of Human Biology, vol 18, no. 3, pp. 342-349.

Mikkola, T, Sipila, S, Sievanen, H, Suominen, H, Rantanen, T, Kaprio, J, Koskenvuo, M, Kauppinen, M, Heinonen, A 2006, 'Genetic and environmental contributions on bone strength in older women.', Journal of Bone and Mineral Research, vol 21, pp. S240-S240.

Minassian, S, Palmer, C, Turunen, J, Paunio, T, Lönnqvist, J, Peltonen, L, Woodward, J, Sinsheimer, JS 2006, 'Incorporating serotypes into family based association studies using the MFG test', Annals of Human Genetics, vol 70, no. 4, pp. 541-553.

Mononen, N, Seppälä, EH, Duggal, P, Autio, V, Ikonen, T, Ellonen, P, Saharinen, J, Saarela, J, Vihinen, M, Tammela, TLJ, Kallioniemi, O, Bailey-Wilson, JE, Schleutker, J 2006, 'Profiling genetic variation along the androgen biosynthesis and metabolism pathways implicates several single nucleotide polymorphisms and their combinations as prostate cancer risk factors', Cancer Research, vol 66, no. 2, pp. 743-747.

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Möllsten, A, Wessman, M, Svensson, M, Forsblom, C, Parkkonen, M, Brismar, K, Groop, P, Dahlquist, G 2006, 'Glu298Asp and NOS4ab polymorphisms in diabetic nephropathy', Annals of Medicine, vol 38, pp. 522-528.

Nuutila, P, Hannukainen, J, Borra, R, Viljanen, A, Janatuinen, T, Heinonen, OJ, Kaprio, J, Kujala, U, Ronnemaa, T, Viljanen, T, Haaparanta, M, Knuuti, J, Kalliokoski, KK 2006, 'Heredity-in dependent effects of increased aerobic fitness on liver and adipose tissue FFA uptake', Diabetologia, vol 49, pp. 318-319.

Ortega-Alonso, A, Pedersen, NL, Kujala, UM, Sipilä, S, Törmäkangas, T, Kaprio, J, Koskenvuo, M, Rantanen, T 2006, 'A twin study on the heritability of walking ability among older women', Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, vol 61A, no. 10, pp. 1082-1085.

Pagan, JL, Holliday, C, Rose, RJ, Viken, RJ, Pulkkinen, L, Kaprio, J, Dick, DM 2006, 'The impact of peer substance use on early adolescence alcohol use', Behavior Genetics, vol 36, pp. 978-979.

Pagan, JL, Rose, RJ, Viken, RJ, Pulkkinen, L, Kaprio, J, Dick, DM 2006, 'Genetic and environmental influences on stages of alcohol use across adolescence and into young adulthood', Behavior Genetics, vol 36, pp. 483-497.

Pajala, S, Era, P, Koskenvuo, M, Kaprio, J, Viljanen, A, Rantanen, T 2006, 'Genetic factors and susceptibility to falls in older women', Journal of the American Geriatrics Society, vol 54, no. 4, pp. 613-618.

Pakkasjärvi, N, Ritvanen, A, Herva, R, Peltonen, L, Kestilä, M, Ignatius, J 2006, 'Lethal congenital contracture syndrome (LCCS) and other lethal arthrogryposes in Finland: an epidemiological study', American Journal of Medical Genetics. Part A, vol 140A, no. 17, pp. 1834-1839.

Palmer, C, Hsieh, H, Reed, E, Lönnqvist, J, Peltonen, L, Woodward, A, Sinsheimer, JS 2006, 'HLA-B maternal-fetal genotype matching increases risk of schizophrenia', American Journal of Human Genetics, vol 79, no. 4, pp. 710-715.

Palotie, L, Perola, M, Naukkarinen, J, Palotie, A 2006, 'Lessons from studying monogenic disease for common disease', Human Molecular Genetics, vol 15, no. Review issue 1, pp. R67-R74.

Pettersson-Fernholm, K, Fröjdö, S, Fagerudd, J, Thomas, MC, Forsblom, C, Wessman, M, Groop, P 2006, 'The AT2 gene may have a gender-specific effect on kidney function and pulse pressure in type I diabetic patients', Kidney International, vol 69, pp. 1880-1884.

Pietiläinen, KH, Kannisto, K, Korsheninnikova, E, Rissanen, A, Kaprio, J, Ehrenborg, E, Hamsten, A, Yki-Järvinen, H 2006, 'Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins', Journal of Clinical Endocrinology and Metabolism, vol 91, no. 7, pp. 2776-2781.

Pietiläinen, KH, Bergholm, R, Rissanen, A, Kaprio, J, Häkkinen, A, Sattar, N, Yki-Järvinen, H 2006, 'Effects of acquired obesity on endothelial function in monozygotic twins', Obesity, vol 14, no. 5, pp. 826-837.

Portegijs, E, Sipila, S, Pajala, S, Lamb, SE, Alen, M, Kaprio, J, Koskenvuo, M, Rantanen, T 2006, 'Asymmetrical lower extremity power deficit as a risk factor for injurious falls in healthy older women', Journal of the American Geriatrics Society, vol 54, no. 3, pp. 551-553.

Pulkkinen, V, Haataja, R, Hannelius, U, Helve, O, Pitkänen, OM, Karikoski, R, Rehn, M, Marttila, R, Lindgren, CM, Hästbacka, J, Andersson, S, Kere, J, Hallman, M, Laitinen, T 2006, 'G protein-coupled receptor for asthma susceptibility associates with respiratory distress syndrome', Annals of Medicine, vol 38, pp. 357-366.

Pulkkinen, V, Majuri, M, Wang, G, Holopainen, PM, Obase, Y, Vendelin, J, Wolff, H, Rytilä, P, Laitinen, LA, Haahtela, T, Laitinen, T, Alenius, H, Kere, J, Rehn, M 2006, 'Neuropeptide S and G protein-coupled receptor 154 modulate macrophage immune responses', Human Molecular Genetics, vol 15, no. 10, pp. 1667-1679.

Pöntynen, N, Miettinen, A, Arstila, TP, Kämpe, O, Alimohammadi, M, Vaarala, O, Peltonen, L, Ulmanen, I, Arstila, P 2006, 'Aire deficient mice do not develop the same profile of tissue-specific autoantibodies as APECED patients', Journal of Autoimmunity, vol 27, no. 2, pp. 96-104.

Raevuori, A, Keski-Rahkonen, A, Bulik, CM, Rose, RJ, Rissanen, A, Kaprio, J 2006, 'Muscle dissatisfaction in young adult men', Clinical Practice and Epidemiology in Mental Health, vol 2, no. 6, [8, pp. ].

Raevuori, A, Keski-Rahkonen, A, Rose, RJ, Rissanen, A, Kaprio, J 2006, 'Muscle dissatisfaction and muscle-enhancing substance use: A population-based twin study in young adult men', Twin Research and Human Genetics, vol 9, no. 3, pp. 431-437.

Ramsey, C, Hässler, S, Marits, P, Kämpe, O, Surh, CD, Palotie, L, Winqvist, O 2006, 'Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator', European Journal of Immunology, vol 36, no. 2, pp. 305-317.

Rautanen, A, Eriksson, JG, Kere, J, Andersson, S, Osmond, C, Tienari, PJ, Sairanen, H, Barker, DJP, Phillips, DIW, Forsen, T, Kajantie, E 2006, 'Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene', Journal of Clinical Endocrinology and Metabolism, vol 91, pp. 4544-4551.

Rehnström, K, Yliaukko-oja, T, Nieminen-von Wendt, T, Sarenius, S, Källman, T, Kempas, E, Wendt, LV, Peltonen, L, Järvelä, I 2006, 'Independent replication and initial fine mapping of 3p21-24 in Asperger syndrome: [electronic letter]', Journal of Medical Genetics, vol 43, no. 2.

Russell, MB, Kaprio, J, Levi, N 2006, 'Genetics of tension-type headache', Cephalalgia, vol 26, pp. 1363-1363.

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Rönnback, M, Isomaa, B, Fagerudd, J, Forsblom, C, Groop, P, Tuomi, T, Groop, L 2006, 'Complex relationship between blood pressure and mortality in type 2 diabetic patients: a follow-up of the Botnia Study', Hypertension, vol 47, pp. 168-173.

Saarela, J, Kallio, S, Chen, D, Montpetit, A, Jokiaho, A, Choi, E, Asselta, R, Bronnikov, D, Lincoln, MR, Sadovnick, AD, Tienari, PJ, Koivisto, K, Palotie, A, Ebers, GC, Hudson, TJ, Peltonen, L 2006, 'PRKCA and multiple sclerosis: association in two independent populations', PLoS Genetics, vol 2, no. 3, pp. 364-75.

Saarela, J, Kallio, SP, Chen, D, Montpetit, A, Lincoln, MR, Palotie, A, Ebers, GC, Hudson, TJ, Palotie, L 2006, 'PRKCA and multiple sclerosis: Association in independent populations', Journal of Neuroimmunology, vol 178, pp. 39-39.

Saarni, SE, Rissanen, A, Sarna, S, Koskenvuo, M, Kaprio, J 2006, 'Weight cycling of athletes and subsequent weight gain in middleage', International Journal of Obesity, vol 30, no. 11, pp. 1639-1644.

Salmela, E, Taskinen, O, Seppänen, JK, Sistonen, P, Daly, MJ, Lahermo, P, Savontaus, M, Kere, J 2006, 'Subpopulation difference scanning: a strategy for exclusion mapping of susceptibility genes', Journal of Medical Genetics, vol 43, no. 7, pp. 590-597.

Saxena, R, Gianniny, L, Burtt, NP, Lyssenko, V, Giuducci, C, Sjögren, M, Florez, JC, Almgren, P, Isomaa, B, Orho-Melander, M, Lindblad, U, Daly, MJ, Tuomi, T, Hirschhorn, JN, Ardlie, KG, Groop, LC, Altshuler, D 2006, 'Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals', Diabetes, vol 55, pp. 2890-2895.

Schumacher, J, Anthoni, H, Dahdouh, F, König, IR, Hillmer, AM, Kluck, N, Manthey, M, Plume, E, Warnke, A, Remschmidt, H, Hulsmann, J, Cichon, S, Lindgren, CM, Propping, P, Zucchelli, M, Ziegler, A, Peyrard-Janvid, M, Schulte-Körne, G, Nöthen, MM, Kere, J 2006, 'Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia', American Journal of Human Genetics, vol 78, no. 1, pp. 52-62.

Service, S, DeYoung, J, Karayiorgou, M, Roos, JL, Pretorious, H, Bedoya, G, Ospina, J, Ruiz-Linares, A, Macedo, A, Palha, JA, Heutink, P, Aulchenko, Y, Oostra, B, van Duijn, C, Jarvelin, MR, Varilo, T, Peddle, L, Rahman, P, Piras, G, Monne, M, Murray, S, Galver, L, Palotie, L, Sabatti, C, Collins, A, Freimer, N 2006, 'Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies', Nature Genetics, vol 38, no. 5, pp. 556-560.

Sihvola, R, Koskinen, PK, Pulkkinen, VP, Tikkanen, JM, Lemström, K, Lemström, KB, Sihvola, RK 2006, 'Inhibition of tumor necrosis factor-[alpha] attenuates myocardial remodeling in rat cardiac allografts', Journal of Heart and Lung Transplantation, vol 25, pp. 569-578.

Silventoinen, K, Zdravkovic, S, Skytthe, A, McCarron, P, Herskind, AM, Koskenvuo, M, de Faire, U, Pedersen, N, Christensen, K, Kaprio, J 2006, 'Association between height and coronary heart disease mortality: A prospective study of 35,000 twin pairs', American Journal of Epidemiology, vol 163, pp. 615-621.

Soro-Paavonen, A, Westerbacka, J, Ehnholm, C, Taskinen, M 2006, 'Metabolic syndrome aggravates the increased endothelial activation and low-grade inflammation in subjects with familial low HDL', Annals of Medicine, vol 38, pp. 229-238.

Stubbe, JH, Boomsma, DI, Vink, JM, Cornes, BK, Martin, NG, Skytthe, A, Kyvik, KO, Rose, RJ, Kujala, UM, Kaprio, J, Harris, JR, Pedersen, NL, Hunkin, J, Spector, TD, de Geus, EJC 2006, 'Genetic influences on exercise participation in 37.051 twin pairs from seven countries', PLoS One, vol 1, no. 1, pp. e22.

Sun, MW, Lee, JY, de Bakker, PIW, Burtt, NP, Almgren, P, Råstam, L, Tuomi, T, Gaudet, D, Daly, MJ, Hirschhorn, JN, Altshuler, D, Groop, L, Florez, JC 2006, 'Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB1 with type 2 diabetes', Diabetes, vol 55, pp. 849-855.

Suviolahti, E, Reue, K, Cantor, RM, Phan, J, Gentile, M, Naukkarinen, J, Soro-Paavonen, A, Oksanen, L, Kaprio, J, Rissanen, A, Salomaa, V, Kontula, K, Taskinen, M, Pajukanta, P, Peltonen, L 2006, 'Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism', Human Molecular Genetics, vol 15, no. 3, pp. 377-386.

Särkijärvi, S, Kuusisto, H, Paalavuo, R, Levula, M, Airla, N, Lehtimäki, T, Kaprio, J, Koskenvuo, M, Elovaara, I 2006, 'Gene expression profiles in Finnish twins with multiple sclerosis', BMC Medical Genetics, vol 7, no. 11.

Thomas, MC, Rosengård-Bärlund, M, Mills, V, Rönnback, M, Thomas, S, Forsblom, C, Cooper, ME, Taskinen, M, Viberti, G, Groop, P 2006, 'Serum lipids and the progression of nephropathy in type 1 diabetes', Diabetes Care, vol 29, no. 2, pp. 317-322.

Tiira, K, Laurila, A, Enberg, K, Piironen, J, Aikio, S, Ranta, E, Primmer, CR 2006, 'Do dominants have higher heterozygosity?: social status and genetic variation in brown trout, Salmo trutta', Behavioral Ecology and Sociobiology, vol 59, pp. 657-665.

Tiira, K, Piironen, J, Primmer, CR 2006, 'Evidence for reduced genetic variation in severely deformed juvenile salmonids', Canadian Journal of Fisheries and Aquatic Sciences, vol 63, pp. 2700-2707.

Tikkanen, HO, Waden, J, Forsblom, C, Thorn, L, Fagerudd, J, Pettersson-Fernholm, K, Tikkanen, H, Turunen, J, Wessman, M, Rosengard-Barlund, M, Heikkila, O, Saraheimo, M, Groop, P- 2006, 'Leisure-time physical activity is associated with the metabolic syndrome in type 1 diabetes; interaction with the Pro12Ala variant of the PPAR gamma Gene (The Finn-Diane Study)', Diabetologia, vol 49, pp. 442-443.

Tomppo, L, Hennah, W, Lahermo, P, Loukola, A, Ekelund, J, Partonen, T, Palotie, A, Lonnqvist, J, Palotie, L 2006, 'Association evidence from NUDEL and PDE4D support the disc 1-pathway concept in the etiology of schizophrenia', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 141B, pp. 717-717.

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Trikalinos, TA, Karvouni, A, Zintzaras, E, Ylisaukko-oja, T, Peltonen, L, Järvelä, I, Ioannidis, JPA 2006, 'A heterogeneity-based genome search meta-analysis for autism-spectrum disorders', Molecular Psychiatry, vol 11, no. 1, pp. 29-36.

Tuomi, T, Honkanen, EH, Isomaa, B, Sarelin, L, Groop, LC 2006, 'Improved prandial glucose control with lower risk of hypoglycemia with nateglinide than with glibenclamide in patients with maturity-onset diabetes of the young type 3', Diabetes Care, vol 29, pp. 189-194.

Turunen, JA, Wessman, M, Kilpikari, R, Parkkonen, M, Forsblom, C, Groop, P 2006, 'The functional variant - 169C/T in the FCRL3 gene does not increase susceptibility to type 1 diabetes: [Letters]', Diabetic Medicine, vol 23, pp. 925-927.

Turunen, JA, Wessman, M, Forsblom, C, Kilpikari, R, Parkkonen, M, Pöntynen, N, Ilmarinen, T, Ulmanen, I, Peltonen, L, Groop, P 2006, 'Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients', Immunogenetics, vol 58, pp. 331-338.

Urrila, A, Hakkarainen, A, Heikkinen, S, Huhdankoski, O, Kuusi, T, Stenberg, D, Häkkinen, A, Porkka-Heiskanen, T, Lundbom, N 2006, 'Preliminary findings of proton magnetic resonance spectroscopy in occipital cortex during sleep deprivation', Psychiatry Research: Neuroimaging, vol 147, no. 1, pp. 41-46.

Valli-Jaakola, KM, Palvimo, J, Lipsanen-Nyman, M, Salomaa, V, Peltonen, L, Kontula, K, Schalin-Jäntti, C 2006, 'A two-base deletion -439delGC in the melanocortin-4 receptor promoter associated with early-onset obesity', Hormone Research, vol 66, pp. 61-69.

Vendelin, J, Bruce, S, Holopainen, PM, Pulkkinen, V, Rytilä, P, Pirskanen, A, Rehn, M, Laitinen, T, Laitinen, L, Haahtela, T, Saarialho-Kere, U, Laitinen, A, Kere, J, Laitinen, LA 2006, 'Downstream target genes of the neuropeptide S-NPSR1 pathway', Human Molecular Genetics, vol 15, no. 19, pp. 2923-2935.

Videman, T, Battie, MC, Ripatti, S, Gill, K, Manninen, H, Kaprio, J 2006, 'Determinants of the progression in lumbar degeneration - A 5-year follow-up study of adult male monozygotic twins', Spine, vol 31, no. 6, pp. 671-678.

Vierikko, E, Pulkkinen, L, Kaprio, J, Rose, RJ 2006, 'Genetic and environmental sources of continuity and change in teacher-rated aggression during early adolescence', Aggressive Behavior, vol 32, no. 4, pp. 308-320.

Viitasalo, M, Oikarinen, L, Swan, H, Glatter, KA, Väänänen, H, Fodstad, H, Chiamvimonvat, N, Kontula, K, Toivonen, L, Scheinman, MM 2006, 'Ratio of late to early T-wave peak amplitude in 24-h electrocardiographic recordings as indicator of symptom history in patients with long-QT syndrome types 1 and 2', Journal of the American College of Cardiology, vol 47, pp. 112-120.

Wang, Y, Paramasiwam, M, Thomas, A, Bai, J, Kaminen-Ahola, N, Kere, J, Voskuil, J, Rosen, GD, Galaburda, AM, Loturco, JJ 2006, 'DYX1C1 functions in neuronal migration in developing neocortex', Neuroscience, vol 143, no. 2, pp. 515-522.

Watanabe, H, Söderlund, S, Soro-Paavonen, A, Hiukka, A, Leinonen, E, Alagona, C, Salonen, R, Tuomainen, T, Ehnholm, C, Jauhiainen, M, Taskinen, M 2006, 'Decreased high-density lipoprotein (HDL) particle size, prebeta-, and large HDL subspecies concentration in Finnish low-HDL families: relationship with intima-media thickness', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 26, pp. 897-902.

Weissglas-Volkov, D, Huertas-Vazquez, A, Suviolahti, E, Lee, J, Plaisier, C, Canizales-Quinteros, S, Tusie-Luna, T, Aguilar-Salinas, C, Taskinen, M, Pajukanta, P 2006, 'Common hepatic nuclear factor-4alpha variants are associated with high serum lipid levels and the metabolic syndrome', Diabetes, vol 55, pp. 1970-1977.

Ylisaukko-oja, T, Alarcon, M, Cantor, RM, Auranen, M, Vanhala, R, Kempas, E, Wendt, LV, Järvelä, I, Geschwind, DH, Peltonen, L 2006, 'Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families', Annals of Neurology, vol 59, no. 1, pp. 145-155.

Zintzaras, E, Kitsios, G, Harrison, GA, Laivuori, H, Kivinen, K, Kere, J, Messinis, I, Stefanidis, I, Ioannidis, JPA 2006, 'Heterogeneity-based genome search meta-analysis for preeclampsia', Human Genetics, vol 120, no. 3, pp. 360-370.

2007 Adiels, M, Westerbacka, J, Soro-Paavonen, A, Häkkinen, A, Vehkavaara, S, Caslake, MJ, Packard, C, Olofsson, S, Yki-Järvinen, H, Taskinen, M, Boren, J 2007, 'Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance', Diabetologia, vol 50, pp. 2356-2365.

Ala-Korpela, M, Lankinen, N, Salminen, A, Suna, T, Soininen, P, Laatikainen, R, Ingman, P, Jauhiainen, M, Taskinen, M, Heberger, K, Kaski, K 2007, 'The inherent accuracy of 1H NMR spectroscopy to quantify plasma lipoproteins is subclass dependent', Atherosclerosis, vol 190, no. 2, pp. 352-358.

Alanne, M, Kristiansson, K, Auro, K, Silander, K, Kuulasmaa, K, Peltonen, L, Salomaa, V, Perola, M 2007, 'Variation in the selenoprotein S gene locus is associated with coronary heart disease and ischemic stroke in two independent Finnish cohorts', Human Genetics, vol 122, no. 3/4, pp. 355-365.

Anthoni, H, Zucchelli, M, Matsson, H, Muller-Myhsok, B, Fransson, I, Schumacher, J, Massinen, S, Onkamo, P, Warnke, A, Grieseman, H, Hoffmann, P, Nopola-Hemmi, J, Lyytinen, H, Schulte-Körne, G, Kere, J, Nöthen, MM, Peyrard-Janvid, M 2007, 'A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia', Human Molecular Genetics, vol 16, no. 6, pp. 667-677.

Artto, V, Nissilä, M, Wessman, M, Palotie, A, Färkkilä, M, Kallela, M 2007, 'Treatment of hemiplegic migraine with triptans', European Journal of Neurology, vol 14, no. 9, pp. 1053-1056.

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Auro, K, Alanne, M, Kristiansson, K, Silander, K, Kuulasmaa, K, Salomaa, V, Peltonen, L, Perola, M 2007, 'Combined effects of thrombosis pathway gene variants predict cardiovascular events', PLoS Genetics, vol 3, no. 7.

Baker, SG, Kaprio, J 2007, 'Genes, cancer, and twins: the statistics behind the headlines', Chance (New York, 1988), vol 20, no. 3, pp. 59-62.

Barone, S, Amlal, H, Kujala, M, Xu, J, Karet, F, Blanchard, A, Kere, J, Soleimani, M 2007, 'Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion', Nephrology, Dialysis, Transplantation , vol 22, no. 12, pp. 3462-3470.

Battie, MC, Videman, T, Levälahti, E, Gill, K, Kaprio, J 2007, 'Heritability of low back pain and the role of disc degeneration', Pain : the journal of the International association for the study of pain, vol 131, no. 3, pp. 272-280.

Bearden, CE, Dutton, RA, van Erp, TGM, Cannon, TD, Kieseppa, T, Haukka, J, Partonen, T, Poutanen, V, Kaprio, J, Lonnqvist, J, Thompson, PM 2007, 'Mapping corpus callosum deficits in twins discordant for bipolar disorder', Biological Psychiatry, vol 61, pp. 185S-185S.

Bernard, M, Rose, R, Viken, R, Pulkkinen, L, Kaprio, J, Dick, DM 2007, 'Moderating effects of urban-rural residency on adolescent behavior problems and frequency of alcohol use', Behavior Genetics, vol 37, pp. 739-739.

Broms, U, Madden, PAF, Heath, AC, Pergadia, ML, Shiffman, S, Kaprio, J 2007, 'The nicotine dependence syndrome scale in Finnish smokers', Drug and Alcohol Dependence, vol 89, no. 1, pp. 42-51.

Bulik, CM, Hebebrand, J, Keski-Rahkonen, A, Klump, KL, Reichborn-Kjennerud, T, Mazzeo, SE, Wade, TD 2007, 'Genetic epidemiology, endophenotypes, and eating disorder classification', International Journal of Eating Disorders, vol 40, pp. 52-60.

Campbell, CD, Lyon, HN, Nemesh, J, Drake, JA, Tuomi, T, Gaudet, D, Zhu, X, Cooper, RS, Ardlie, KG, Groop, LC, Hirschhorn, JN 2007, 'Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men', Diabetes, vol 56, pp. 1460-1467.

D'Amato, M, Bruce, S, Bresso, F, Zucchelli, M, Ezer, S, Pulkkinen, V, Lindgren, C, Astegiano, M, Rizzetto, M, Gionchetti, P, Riegler, G, Sostegni, R, Daperno, M, D'Alfonso, S, Momigliano-Richiardi, P, Torkvist, L, Puolakkainen, P, Lappalainen, M, Paavola-Sakki, P, Halme, L, Farkkila, M, Turunen, U, Kontula, K, Lofbergh, R, Pettersson, S, Kere, J 2007, 'Neuropeptide S receptor 1 gene polymorphism is associated with susceptibility to inflammatory bowel disease', Gastroenterology, vol 133, no. 3, pp. 808-817.

Dahlman, I, Dicker, A, Jiao, H, Kere, J, Blomqvist, L, van Harmelen, V, Hoffstedt, J, Borch-Johnsen, K, Jorgensen, T, Hansen, T, Pedersen, O, Laakso, M, Arner, P 2007, 'A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis', American Journal of Human Genetics, vol 2007, no. 80, pp. 1115-1124.

Dick, DM, Pagan, JL, Holliday, C, Viken, R, Pulkkinen, L, Kaprio, J, Rose, RJ 2007, 'Gender differences in friends' influences on adolescent drinking: A genetic epidemiological study', Alcoholism: Clinical and Experimental Research, vol 31, no. 12, pp. 2012-2019.

Dick, DM, Pagan, JL, Viken, R, Purcell, S, Kaprio, J, Pulkkinen, L, Rose, RJ 2007, 'Changing environmental influences on substance use across development', Twin Research and Human Genetics, vol 10, no. 2, pp. 315-326.

Dick, DM, Viken, R, Purcell, S, Kaprio, J, Pulkkinen, L, Rose, RJ 2007, 'Parental monitoring moderates the importance of genetic and environmental influences on adolescent smoking', Journal of Abnormal Psychology, vol 116, no. 1, pp. 213-218.

Donescu, OS, Battie, MC, Kaprio, J, Levälahti, E, Risteli, J, Eyre, D, Videman, T 2007, 'Genetic and constitutional influences on bone turnover markers: A study of male twin pairs', Calcified Tissue International, vol 80, no. 12, pp. 81-88.

Durette-Desset, M, Lehtonen, JT, Haukisalmi, V 2007, 'Trichostrongylina (Nematoda) from Malagasy Muridae III: description of a new species of Heligmonoides Baylis, 1928 (Heligmonellidae) parasitic in Mus Musculus', Parasite, vol 14, pp. 53-60.

Enattah, N, Kuokkanen, M, Forsblom, C, Natah, S, Oksanen, A, Järvelä, I, Peltonen, L, Savilahti, E 2007, 'Correlation of intestinal disaccharidase activities with the C/T-13910 variant and age', World Journal of Gastroenterology, vol 13, no. 25, pp. 3508-3512.

Enattah, NS, Trudeau, A, Pimenoff, V, Maiuri, L, Auricchio, S, Greco, L, Rossi, M, Lentze, M, Seo, JK, Rahgozar, S, Khalil, I, Alifrangis, M, Natah, S, Groop, L, Shaat, N, Kozlov, A, Verschubskaya, G, Comas, D, Bulayeva, K, Mehdi, SQ, Terwilliger, JD, Sahi, T, Savilahti, E, Perola, M, Sajantila, A, Järvelä, I, Peltonen, L 2007, 'Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans', American Journal of Human Genetics, vol 81, no. 3, pp. 615-625.

Erkko, H, Xia, B, Nikkilä, J, Schleutker, J, Syrjäkoski, K, Mannermaa, A, Kallioniemi, A, Pylkäs, K, Karppinen, S, Rapakko, K, Miron, A, Sheng, Q, Li, G, Mattila, H, Bell, DW, Haber, DA, Grip, M, Reiman, M, Jukkola-Vuorinen, A, Mustonen, A, Kere, J, Aaltonen, LA, Kosma, V, Kataja, V, Soini, Y, Drapkin, RI, Livingston, DM, Winqvist, R 2007, 'A recurrent mutation in PALB2 in Finnish cancer families', Nature, vol 446, no. 7133, pp. 316-319.

Florez, JC, Sjögren, M, Agapakis, CM, Burtt, NP, Almgren, P, Lindblad, U, Berglund, G, Tuomi, T, Gaudet, D, Daly, MJ, Ardlie, KG, Hirschhorn, JN, Altshuler, D, Groop, L 2007, 'Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes', Diabetologia, vol 50, pp. 1209-1217.

Fredriksson, J, Anevski, D, Almgren, P, Sjogren, M, Lyssenko, V, Carlson, J, Isomaa, B, Taskinen, M, Groop, L, Orho-Melander, M, Botnia Study Group 2007, 'Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality', PLoS One.

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Färkkilä, M, Kallela, M 2007, 'Frovatriptan review', Expert Opinion on Pharmacotherapy, vol 8, pp. 3029-3033.

Gasbarra, D, Pirinen, M, Sillanpää, MJ, Salmela, E, Arjas, E 2007, 'Estimating genealogies from unlinked marker data: a Bayesian approach', Theoretical Population Biology, vol 72, no. 3, pp. 305-322.

Gillard, GO, Dooley, J, Erickson, M, Peltonen, L, Farr, AG 2007, 'Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation', Journal of Immunology, vol 178, no. 5, pp. 3007-3015.

Graner, M, Syvänne, M, Kahri, J, Nieminen, MS, Taskinen, M 2007, 'Insulin resistance as predictor of the angiographic severity and extent of coronary artery disease', Annals of Medicine, vol 39, pp. 137-144.

Graner, M, Lommi, J, Kupari, M, Räisänen-Sokolowski, A, Toivonen, L 2007, 'Multiple forms of sustained monomorphic ventricular tachycardia as common presentation in giant-cell myocarditis', Heart, vol 93, pp. 119-121.

Groop, P, Thomas, MC, Rosengård-Bärlund, M, Mills, V, Rönnback, M, Thomas, S, Forsblom, C, Taskinen, M, Viberti, G 2007, 'HDL composition predicts new-onset cardiovascular disease in patients with type 1 diabetes', Diabetes Care, vol 30, pp. 2706-2707.

Gunnell, AS, Ylitalo, N, Sandin, S, Sparen, P, Adami, H-, Ripatti, S 2007, 'A longitudinal Swedish study on screening for squamous cell carcinoma and adenocarcinoma: Evidence of effectiveness and overtreatment', Cancer Epidemiology, Biomarkers & Prevention, vol 16, pp. 2641-2648.

Hannelius, U, Gherman, L, Makela, V, Lindstedt, A, Zucchelli, M, Lagerberg, C, Tybring, G, Kere, J, Lindgren, CM 2007, 'Large-scale zygosity testing using single nucleotide polymorphisms', Twin Research and Human Genetics, vol 10, no. 4, pp. 604-625.

Hannukainen, JC, Janatuinen, T, Toikka, JO, Järvisalo, MJ, Heinonen, OJ, Kapanen, J, Någren, K, Nuutila, P, Kujala, UM, Kaprio, J, Knuuti, J, Kalliokoski, KK 2007, 'Myocardial and peripheral vascular functional adaptation to exercise training', Scandinavian Journal of Medicine & Science in Sports, vol 17, no. 2, pp. 139-147.

Hannukainen, JC, Nuutila, P, Ronald, B, Kaprio, J, Kujala, UM, Janatuinen, T, Heinonen, OJ, Kapanen, J, Viljanen, T, Haaparanta, M, Rönnemaa, T, Parkkola, R, Knuuti, J, Kalliokoski, KK 2007, 'Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins', Journal of Physiology, vol 578, no. Pt 1, pp. 347-358.

Hedlund, E, Kaprio, J, Lange, A, Koskenvuo, M, Jartti, L, Rönnemaa, T, Hammar, N 2007, 'Migration and coronary heart disease: a study of Finnish twins living in Sweden and their co-twins residing in Finland', Scandinavian Journal of Public Health, vol 35, pp. 468-474.

Heinonen-Guzejev, M, Vuorinen, HS, Mussalo-Rauhamaa, H, Heikkilä, KV, Koskenvuo, M, Kaprio, J 2007, 'The association of noise sensitivity with coronary heart and cardiovascular mortality among Finnish adults', Science of the Total Environment, vol 372, no. 2-3, pp. 406-412.

Hellquist, A, Zucchelli, M, Kivinen, K, Saarialho-Kere, U, Koskenmies, S, Widen, E, Julkunen, H, Wong, A, Karjalainen-Lindsberg, M, Skoog, T, Vendelin, J, Cunninghame-Graham, D, Vyse, T, Kere, J, Lindgren, CM 2007, 'The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus', Journal of Medical Genetics, vol 44, no. 5, pp. 314-321.

Hennah, W, Tomppo, L, Hiekkalinna, T, Palo, O, Kilpinen, H, Ekelund, J, Tuulio-Henriksson, A, Silander, K, Partonen, T, Paunio, T, Terwilliger, JD, Lönnqvist, J, Peltonen, L 2007, 'Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1', Human Molecular Genetics, vol 16, no. 5, pp. 453-462.

Hiltunen, TP, Suonsyrjä, T, Hannila-Handelberg, T, Paavonen, KJ, Miettinen, HE, Strandberg, T, Tikkanen, I, Tilvis, R, Pentikäinen, PJ, Virolainen, J, Kontula, K 2007, 'Predictors of antihypertensive drug responses: initial data from a placebo-controlled, randomized, cross-over study with four antihypertensive drugs (The GENRES Study)', American Journal of Hypertension, vol 20, pp. 311-318.

Hiltunen, L, Rautiainen, A, Rasi, V, Kaaja, R, Kere, J, Krusius, T, Vahtera, E, Paunio, M 2007, 'An unfavorable combination of factor V Leiden with age, weight, and blood group causes high risk of pregnancy-associated venous thrombosis - a population-based nested case-control study', Thrombosis Research, vol 119, no. 4, pp. 423-432.

Hiukka, A, Leinonen, E, Jauhiainen, M, Sundvall, J, Ekholm, C, Keech, AC, Taskinen, M 2007, 'Long-term effects of fenofibrate on VLDL and HDL subspecies in participants with type 2 diabetes mellitus', Diabetologia, vol 50, no. 10, pp. 2067-2075.

Holmkvist, J, Tojjar, D, Almgren, P, Lyssenko, V, Lindgren, CM, Isomaa, B, Tuomi, T, Berglund, G, Renström, E, Groop, L 2007, 'Polymorphisms in the gene encoding the voltage-dependent Ca2+ channel Cav2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion', Diabetologia, vol 50, pp. 2467-2475.

Hublin, C, Partinen, M, Koskenvuo, M, Kaprio, J 2007, 'Sleep and mortality: A population-based 22-year follow-up study', Sleep., vol 30, pp. 1245-1253.

Hugot, J, Zaccaria, I, Cavanaugh, J, Yang, H, Vermeire, S, Lappalainen, M, Schreiber, S, Annese, V, Jewell, DP, Fowler, EV, Brant, SR, Silverberg, MS, Cho, J, Rioux, JD, Satsangi, J, Parkes, M, Heliö, T, Kontula, K, Paavola-Sakki, P 2007, 'Prevalence of CARD15/NOD2 mutations in Caucasian healthy people', American Journal of Gastroenterology, vol 102, pp. 1259-1267.

Huizink, AC, Korhonen, T, Levälahti, E, Dick, DM, Rose, RJ, Pulkkinen, L, Kaprio, J 2007, 'Testing the gateway model in Finnish adolescent twins: Progression from cigarette smoking to cannabis use', Behavior Genetics, vol 37, pp. 763-764.

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Huizink, AC, Dick, DM, Sihvola, E, Pulkkinen, L, Rose, RJ, Kaprio, J 2007, 'Chernobyl exposure as stressor during pregnancy and behaviour in adolescent offspring', Acta Psychiatrica Scandinavica, vol 116, no. 6, pp. 438-446.

Jokinen, TS, Metsähonkala, L, Bergamasco, L, Viitmaa, R, Syrja, P, Lohi, H, Snellman, M, Jeserevics, J, Cizinauskas, S 2007, 'Benign familial juvenile epilepsy in Lagotto Romagnolo dogs', Journal of Veterinary Internal Medicine, vol 21, no. 3, pp. 464-471.

Järvinen, T, Kanninen, P, Jeskanen, L, Koskenmies, S, Panelius, J, Hasan, T, Ranki, A, Saarialho-Kere, U 2007, 'Matrix metalloproteinases as mediators of tissue injury in different forms of cutaneous lupus erythematosus', British Journal of Dermatology, vol 157, no. 5, pp. 970-980.

Kaartinen, M, Heliö, T, Lehtonen, A, Lahtinen, AM, Kärkkäinen, S, Keto, P, Kontula, K, Toivonen, L 2007, 'Characterization of familial and sporadic arrhythmogenic right ventricular cardiomyopathy in Finland', Annals of Medicine, vol 39, no. 4, pp. 312-318.

Kahri, J, Fruchart-Najib, J, Matikainen, N, Fruchart, J, Vakkilainen, J, Taskinen, M 2007, 'The increase of apolipoprotein A-V during postprandial lipemia parallels the response of triglyceride-rich lipoproteins in type 2 diabetes: no relationship between apoA-V and postheparin plasma lipolytic activity', Diabetes Care, vol 30, no. 8, pp. 2083-2085.

Kaprio, J 2007, 'Differences in smoking habits of MZ and DZ twins: a commentary on Tishler and Carey', Twin Research and Human Genetics, vol 10, no. 5, pp. 718-720.

Keech, AC, Mitchell, P, Summanen, P, O'Day, J, Davis, TME, Moffitt, MS, Taskinen, M, Simes, RJ, Tse, D, Williamson, E, Merrifield, A, Laatikainen, LT, d'Emden, MC, Crimet, DC, O'Connell, RL, Colman, PG, Laatikainen, L, FIELD study investigators 2007, 'Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial', Lancet, vol 370, no. 9600, pp. 1687-1697.

Kerkela, E, Skottman, H, Friden, B, Bjuresten, K, Kere, J, Hovatta, O 2007, 'Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome', Fertility and Sterility : official journal of the American Fertility Society , vol 2007, no. 87, pp. 603-606.

Keski-Rahkonen, A, Hoek, HW, Susser, ES, Linna, MS, Sihvola, E, Raevuori, A, Bulik, CM, Kaprio, J, Rissanen, A 2007, 'Epidemiology and course of anorexia nervosa in the community', American Journal of Psychiatry, vol 164, no. 8, pp. 1259-1265.

Keski-Rahkonen, A, Bulik, CM, Pietiläinen, KH, Rose, RJ, Kaprio, J, Rissanen, A 2007, 'Eating styles, overweight and obesity in young adult twins', European Journal of Clinical Nutrition, vol 61, no. 7, pp. 822-829.

Keskitalo, K, Tuorila, H, Spector, TD, Cherkas, LF, Knaapila, A, Silventoinen, K, Perola, M 2007, 'Same genetic components underlie different measures of sweet taste preference', American Journal of Clinical Nutrition, vol 86, no. 6, pp. 1663-1669.

Keskitalo, K, Knaapila, A, Kallela, M, Palotie, A, Wessman, M, Sammalisto, S, Peltonen, L, Tuorila, H, Perola, M 2007, 'Sweet taste preferences are partly genetically determined: identification of a trait locus on chromosome 16¹³', American Journal of Clinical Nutrition, vol 86, no. 1, pp. 55-63.

Kiialainen, AK, Veckman, V, Saharinen, JMN, Paloneva, J, Gentile, M, Hakola, P, Hemelsoet, D, Ridha, B, Kopra, O, Julkunen, I, Peltonen, L 2007, 'Transcript profiles of dendritic cells of PLOSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response', Journal of Molecular Medicine, vol 85, no. 9, pp. 971-983.

Kivinen, K, Peterson, H, Hiltunen, L, Laivuori, H, Heino, S, Tiala, I, Knuutila, S, Rasi, V, Kere, J 2007, 'Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample', European Journal of Human Genetics, vol 15, no. 4, pp. 494-497.

Knaapila, A, Keskitalo, K, Kallela, M, Wessman, M, Sammalisto, S, Hiekkalinna, T, Palotie, A, Peltonen, L, Tuorila, H, Perola, M 2007, 'Genetic component of identification, intensity and pleasantness of odours: a Finnish family study', European Journal of Human Genetics, vol 15, no. 5, pp. 596-602.

Knaapila, A, Tuorila, H, Silventoinen, K, Keskitalo, K, Kallela, M, Wessman, M, Peltonen, L, Cherkas, LF, Spector, TD, Perola, M 2007, 'Food neophobia shows heritable variation in humans', Physiology & Behavior, vol 91, no. 5, pp. 573-578.

Kontula, K 2007, 'Silmät auki ja kynä käteen - valtuuskunnan vaalit lähestyvät: [pääkirjoitus]', Duodecim, vol 123, pp. 5-6.

Korhonen, T, Broms, U, Varjonen, J, Romanov, K, Koskenvuo, M, Kinnunen, T, Kaprio, J 2007, 'Smoking behaviour as a predictor of depression among Finnish men and women: a prospective cohort study of adult twins', Psychological Medicine, vol 37, no. 5, pp. 705-715.

Korhonen, MK, Raevaara, TE, Lohi, H, Nyström, M 2007, 'Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC', Oncology Reports, vol 17, pp. 351-354.

Korponay-Szabo, I, Szabados, K, Pusztai, J, Uhrin, K, Ludmany, E, Nemes, E, Kaukinen, K, Kapitany, A, Koskinen, L, Sipka, S, Imre, A, Mäki, M 2007, 'Population screening for coeliac disease in primary care by district nurses using a rapid antibody test: diagnostic accuracy and feasibility study', BMJ - Clinical Research Edition, vol 335, no. 7632, pp. 1244.1247.

Koskela, AK, Keski-Rahkonen, A, Sihvola, E, Kauppinen, T, Kaprio, J, Ahonen, A, Rissanen, A 2007, 'Serotonin transporter binding of [I-123]ADAM in bulimic women, their healthy twin sisters, and healthy women: a SPET study', BMC Psychiatry, vol 7.

Koskela, A, Keski-Rahkonen, A, Sihvola, E, Kauppinen, T, Kaprio, J, Ahonen, A, Rissanen, A 2007, 'Serotonin transporter binding of [123I] ADAM in bulimic women, their healthy twin sisters and healthy women: a SPET study', BMC Psychiatry, vol 7, no. 19, [9, pp. ].

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Koskenvuo, M, Hublin, C, Partinen, M, Heikkilä, K, Kaprio, J 2007, 'Heritability of diurnal type: a nationwide study of 8753 adult twin pairs', Journal of Sleep Research, vol 16, no. 2, pp. 156-162.

Kotronen, A, Vehkavaara, S, Seppälä-Lindroos, A, Bergholm, R, Yki-Järvinen, H 2007, 'Effect of liver fat on insulin clearance', American Journal of Physiology: Endocrinology and Metabolism, vol 293, pp. E1709-E1715.

Kotronen, A, Westerbacka, J, Bergholm, R, Pietiläinen, KH, Yki-Järvinen, H 2007, 'Liver fat in the metabolic syndrome', Journal of Clinical Endocrinology and Metabolism, vol 92, no. 9, pp. 3490-3497.

Kujala, UM, Kaprio, J, Rose, RJ 2007, 'Physical activity in adolescence and smoking in young adulthood: a prospective twin cohort study', Addiction, vol 102, no. 7, pp. 1151-1157.

Kujala, M, Hihnala, S, Tienari, J, Kaunisto, K, Hastbacka, J, Holmberg, C, Kere, J, Hoglund, P 2007, 'Expression of ion transport-associated proteins in human efferent and epididymal ducts', Reproduction, vol 133, no. 4, pp. 775-784.

Kuusisto, H, Kaprio, J, Dastidar, P, Kinnunen, E, Luukkaala, T, Koskenvuo, M, Elovaara, I 2007, 'Multiple sclerosis in a nationwide series of twins: update after 20 years of follow-up', Multiple Sclerosis, vol 13, pp. S93-S93.

Lajunen, H, Keski-Rahkonen, A, Pulkkinen, L, Rose, RJ, Rissanen, A, Kaprio, J 2007, 'Are computer and cell phone use associated with body mass index and overweight? A population study among twin adolescents', BMC Public Health, vol 7.

Lambe, T, Leung, JCH, Ferry, H, Bouriez-Jones, T, Mäkinen, K, Crockford, TL, Jiang, HR, Nickerson, JM, Peltonen, L, Forrester, JV, Cornall, RJ 2007, 'Limited peripheral T cell anergy predisposes to retinal autoimmunity', Journal of Immunology, vol 178, no. 7, pp. 4276-4283.

Latendresse, SJ, Rose, RJ, Viken, RJ, Pulkkinen, L, Kaprio, J, Dick, DM 2007, 'Parenting and adolescent alcohol use: Data from the Finnish twin studies', Behavior Genetics, vol 37, pp. 770-770.

Latendresse, SJ, Rose, RJ, Viken, RJ, Pulkkinen, L, Kaprio, J, Dick, DM 2007, 'Parental mechanisms of influence on adolescents-alcohol use behaviors', Alcoholism: Clinical and Experimental Research, vol 31, pp. 241A-241A.

Lee-Kirsch, MA, Gong, M, Chowdhury, D, Senenko, L, Engel, K, Lee, Y, de Silva, U, Bailey, SL, Witte, T, Vyse, TJ, Kere, J, Pfeiffer, C, Harvey, S, Wong, A, Koskenmies, S, Hummel, O, Rohde, K, Schmidt, RE, Dominiczak, AF, Gahr, M, Hollis, T, Perrino, FW, Lieberman, J, Huebner, N 2007, 'Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus: [brief communications]', Nature Genetics, vol 39, no. 9, pp. 1065-1067.

Lehtonen, A, Fodstad, H, Laitinen-Forsblom, P, Toivonen, L, Kontula, K, Swan, H 2007, 'Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug-associated torsades de pointes', Heart rhythm., vol 4, pp. 603-607.

Li, W, Zhou, Y, Jentsch, JD, Brown, RAM, Tian, X, Ehninger, D, Hennah, W, Peltonen, L, Lonnqvist, J, Huttunen, MO, Kaprio, J, Trachtenberg, JT, Silva, AJ, Cannon, TD 2007, 'Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice', Proceedings of the National Academy of Sciences of the United States of America, vol 104, no. 46, pp. 18280-18285.

Li, K, Palotie, A, Yuan, S, Bronnikov, D, Chen, D, Wei, X, Choi, O, Saarela, J, Peltonen, L 2007, 'Finding disease candidate genes by liquid association', Genome Biology, vol 8, no. 10.

Liljeström, B, Tuomi, T, Isomaa, B, Sarelin, L, Aktan-Collan, K, Kääriäinen, H 2007, 'Adolescents at risk for MODY3 diabetes prefer genetic testing before adulthood', Diabetes Care, vol 30, pp. 1571-1573.

Lohi, H, Turnbull, J, Zhao, XC, Pullenayegum, S, Ianzano, L, Yahyaoui, M, Mikati, MA, Quinn, NP, Franceschetti, S, Zara, F, Minassian, BA 2007, 'Genetic diagnosis in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls', Neurology, vol 68, no. 13, pp. 996-1001.

Lu, S, Zhao, C, Jiao, H, Kere, J, Tang, X, Zhao, F, Zhang, X, Zhao, K, Larsson, C 2007, 'Two Chinese families with pulverulent congenital cataracts and Delta G91 CRYBA1 mutations', Molecular Vision, vol 2007, no. 13, pp. 1154-1160.

Lundmark, F, Duvefelt, K, Iacobaeus, E, Kockum, I, Wallstroem, E, Khademi, M, Oturai, A, Ryder, LP, Saarela, J, Harbo, HF, Celius, EG, Salter, H, Olsson, T, Hillert, J 2007, 'Variation in interleukin 7 receptor a chain (IL7R) influences risk of multiple sclerosis', Nature Genetics, vol 39, pp. 1108-1113.

Lundqvist, E, Kaprio, J, Verkasalo, PK, Pukkala, E, Koskenvuo, M, Söderberg, KC, Feychting, M 2007, 'Co-twin control and cohort analyses of body mass index and height in relation to breast, prostate, ovarian, corpus uteri, colon and rectal cancer among Swedish and Finnish twins', International Journal of Cancer Research, vol 121, no. 4, pp. 810-818.

Lutkenhoff, ES, van Erp, TG, Thomas, A, Therman, S, Manninen, M, Huttunen, M, Kaprio, J, Lonnqvist, J, Cannon, TD 2007, 'Proton MRS in twins discordant for schizophrenia', Schizophrenia bulletin, vol 33, pp. 394-395.

Lyon, HN, Emilsson, V, Hinney, A, Heid, IM, Lasky-Su, J, Zhu, X, Thorleifsson, G, Gunnarsdottir, S, Walters, B, Thorsteinsdottir, U, Kong, A, Gulcher, J, Nguyen, TT, Scherag, A, Pfeufer, A, Meitinger, T, Brönner, G, Groop, L, Tuomi, T 2007, 'The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts', PLoS Genetics.

Lyssenko, V, Lupi, R, Marchetti, P, Del Guerra, S, Orho-Melander, M, Almgren, P, Sjögren, M, Ling, C, Eriksson, K, Lethagen, Å, Mancarella, R, Berglund, G, Tuomi, T, Nilsson, P, Del Prato, S, Groop, L 2007, 'Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes', Journal of Clinical Investigation, vol 117, pp. 2155-2163.

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Malerba, G, Lindgren, CM, Xumerle, L, Kiviluoma, P, Trabetti, E, Laitinen, T, Galavotti, R, Pescollderungg, L, Boner, AL, Kere, J, Pignatti, PF 2007, 'Chromosome 7p linkage and GPR154 gene association in Italian families with allergic asthma', Clinical and Experimental Allergy, vol 37, no. 1, pp. 83-89.

Matikainen, N, Mänttäri, S, Westerbacka, J, Vehkavaara, S, Lundbom, N, Yki-Järvinen, H, Taskinen, M 2007, 'Postprandial lipemia associates with liver fat content', Journal of Clinical Endocrinology and Metabolism, vol 92, no. 8, pp. 3052-3059.

Mikkola, T, Sipila, S, Rantanen, T, Sievanen, H, Suominen, H, Kaprio, J, Koskenvuo, M, Kauppinen, M, Heinonen, A 2007, 'Genetic and environmental effects on muscle cross-sectional area and structural strength of tibia in older female twins', Journal of Bone and Mineral Research, vol 22, pp. S58-S58.

Muilu, J, Peltonen, L, Litton, J 2007, 'The federated database: a basis for biobank-based post-genome studies, integrating phenome and genome data from 600,000 twin pairs in Europe', European Journal of Human Genetics, vol 15, no. 7, pp. 718-723.

Mustanski, B, Viken, RJ, Kaprio, J, Winter, T, Rose, RJ 2007, 'Sexual Behavior in young adulthood: A population-based twin study', Health Psychology, vol 26, no. 5, pp. 610-617.

Möllsten, A, Marklund, SL, Wessman, M, Svensson, M, Forsblom, C, Parkkonen, M, Brismar, K, Groop, P, Dahlquist, G 2007, 'A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy', Diabetes, vol 56, pp. 265-269.

Nyman, ES, Ogdie, MN, Loukola, A, Varilo, T, Taanila, A, Hurtig, T, Moilanen, IK, Loo, SK, McGough, JJ, Jaervelin, M, Smalley, SL, Nelson, SF, Peltonen, L 2007, 'ADHD candidate gene study in a population-based birth cohort: Association with DBH and DRD2', Journal of the American Academy of Child and Adolescent Psychiatry, vol 46, no. 12, pp. 1614-1621.

Ollikainen, M, Gylling, A, Puputti, M, Nupponen, NN, Abdel-Rahman, WM, Butzow, R, Peltomäki, PT 2007, 'Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma', International Journal of Cancer, vol 121, no. 4, pp. 915-920.

Ollikainen, M, Hannelius, U, Lindgren, CM, Abdel-Rahman, WM, Kere, J, Peltomäki, P 2007, 'Mechanisms of inactivation of MLH1 in hereditary nonpolyposis colorectal carcinoma: a novel approach', Oncogene, vol 26, no. 31, pp. 4541-4549.

Orsmark, C, Skoog, T, Jeskanen, L, Kere, J, Saarialho-Kere, U 2007, 'Expression of allograft inflammatory factor-1 in inflammatory skin disorders', Acta Dermato-Venereologica, vol 87, no. 3, pp. 223-227.

Otonkoski, T, Jiao, H, Kaminen-Ahola, N, Tapia-Paez, I, Ullah, MS, Parton, LE, Schuit, F, Quintens, R, Sipilä, I, Mayatepek, E, Meissner, T, Halestrap, AP, Rutter, GA, Kere, J 2007, 'Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic [beta] cells', American Journal of Human Genetics, vol 81, pp. 467-474.

Paavola, J, Viitasalo, M, Laitinen-Forsblom, PJ, Pasternack, M, Swan, H, Tikkanen, I, Toivonen, L, Kontula, K, Laine , M 2007, 'Mutant ryanodine receptors in catecholaminergic polymorphic ventricular tachycardia generate delayed afterdepolarizations due to increased propensity to Ca2+ waves', European Heart Journal, vol 28, pp. 1135-1142.

Paavonen, KJ, Swan, H, Piippo, K, Laitinen, P, Fodstad, H, Sarna, S, Toivonen, L, Kontula, K, Viitasalo, M 2007, '[beta]1-Adrenergic receptor polymorphisms, QTc interval and occurrence of symptoms in type 1 of long QT syndrome', International Journal of Cardiology, vol 118, no. 2, pp. 197-202.

Pajala, S, Era, P, Koskenvuo, M, Kaprio, J, Tolvanen, A, Rantanen, T 2007, 'Genetic and environmental contribution to postural balance of older women in single and dual task situations', Neurobiology of Aging, vol 28, no. 6, pp. 947-954.

Pakkasjärvi, N, Kerosuo, L, Nousiainen, H, Gentile, M, Saharinen, J, Suhonen, S, Sariola, H, Palotie, L, Kestilä, M, Wartiovaara, K 2007, 'Neural precursor cells from a fatal human motoneuron disease differentiate despite aberrant gene expression', Developmental Neurobiology, vol 67, no. 3, pp. 270-284.

Palo, O, Antila, M, Silander, K, Hennah, W, Kilpinen, H, Soronen, P, Tuulio-Henriksson, A, Kieseppä, T, Partonen, T, Lönnqvist, J, Peltonen, L, Paunio, T 2007, 'Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments', Human Molecular Genetics, vol 16, no. 20, pp. 3517-3528.

Palotie, L 2007, 'Old suspects found guilty – the first genome profile of multiple sclerosis', New England Journal of Medicine, vol 2007/357, no. 9, pp. 927-29.

Panasevich, S, Melen, E, Lindgren, C, Kere, J, Wickman, M, Pershagen, G, Nyberg, F 2007, 'Gene-environment interactions of tumor necrosis factor single nucleoticle polymorphisms with passive smoking and development of asthma symptoms in early childhood', Allergy : European journal of allergy and clinical immunology, vol 62, pp. 58-58.

Parssinen, O, Era, P, Tolvanen, A, Kaprio, J, Koskenvuo, M, Rantanen, T 2007, 'Heritability of intraocular pressure in older female twins', Ophthalmology, vol 114, no. 12, pp. 2227-2231.

Partonen, T, Treutlein, J, Alpman, A, Frank, J, Johansson, C, Depner, M, Aron, L, Rietschel, M, Wellek, S, Soronen, P, Paunio, T, Koch, A, Chen, P, Lathrop, M, Adolfsson, R, Persson, M, Kasper, S, Schalling, M, Peltonen, L, Schumann, G 2007, 'Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression', Annals of Medicine, vol 39, no. 2, pp. 229-238.

Peippo, M, Koivisto, AM, Särkämö, T, Sipponen, M, Koskull, HV, Ylisaukko-oja, T, Rehnström, K, Froyen, G, Ignatius, J, Järvelä, I 2007, 'PAK3 related mental disability: further characterization of the phenotype', American Journal of Medical Genetics. Part A, vol A143, no. 20, pp. 2406-2416.

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Perola, M, Sammalisto, S, Hiekkalinna, T, Martin, NG, Visscher, PM, Montgomery, GW, Benyamin, B, Harris, JR, Boomsma, DI, Willemsen, G, Hottenga, J, Christensen, K, Kyvik, KO, Sørensen, TIA, Pedersen, NL, Magnusson, PKE, Spector, TD, Widen, E, Silventoinen, K, Kaprio, J, Palotie, A, Peltonen, L, GenomEUtwin Project 2007, 'Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci', PLoS Genetics, vol 3, no. 6.

Pietiläinen, KH, Sysi-Aho, M, Rissanen, A, Seppänen-Laakso, T, Yki-Järvinen, H, Kaprio, J, Oresic, M 2007, 'Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects: a monozygotic twin study', PLoS One, vol 2, no. 2, pp. e218.

Porthan, K, Virolainen, J, Hiltunen, TP, Viitasalo, M, Väänänen, H, Dabek, J, Hannila-Handelberg, T, Toivonen, L, Nieminen, MS, Kontula, K, Oikarinen, L 2007, 'Relationship of electrocardiographic repolarization measures to echocardiographic left ventricular mass in men with hypertension', Journal of Hypertension, vol 25, pp. 1951-1957.

Pylkäs, K, Tommiska, J, Syrjäkoski, K, Kere, J, Gatei, M, Waddell, N, Allinen, M, Karppinen, S, Rapakko, K, Kääriäinen, H, Aittomäki, K, Blomqvist, C, Mustonen, A, Holli, K, Khanna, KK, Kallioniemi, O, Nevanlinna, H, Winqvist, R 2007, 'Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer', Carcinogenesis, vol 28, no. 5, pp. 1040-1045.

Raevuori, A, Dick, DM, Keski-Rahkonen, A, Pulkkinen, L, Rose, RJ, Rissanen, A, Kaprio, J, Viken, RJ, Silventoinen, K 2007, 'Genetic and environmental factors affecting self-esteem from age 14 to 17: a longitudinal study of Finnish twins', Psychological Medicine, vol 37, pp. 1625-1633.

Ruan, Q, Tung, K, Eisenman, D, Setiady, Y, Eckenrode, S, Yi, B, Purohit, S, Zheng, W, Zhang, Y, Peltonen, L, She, J 2007, 'The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function', Journal of Immunology, vol 178, no. 11, pp. 7173-7180.

Russell, MB, Levi, N, Kaprio, J 2007, 'Genetics of tension-type headache: A population based twin study', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 144B, no. 8, pp. 982-986.

Saarni, SEM, Pietiläinen, KH, Kantone, S, Rissanen, A, Kaprio, J 2007, 'Smoking in adolescence predicts abdominal obesity in adulthood - A followstudy of five birth cohorts of Finnish twins', International Journal of Obesity, vol 31, pp. S45-S45.

Saarni, SE, Silventoinen, K, Rissanen, A, Sarlio-Lähteenkorva, S, Kaprio, J 2007, 'Recurrent dieting and smoking among Finnish men and women', Obesity, vol 15, no. 7, pp. 1851-1859.

Saccone, SF, Pergadia, ML, Loukola, A, Broms, U, Montgomery, GW, Wang, JC, Agrawal, A, Dick, DM, Heath, AC, Todorov, AA, Maunu, H, Heikkilä, K, Morley, KI, Rice, JP, Todd, RD, Kaprio, J, Peltonen, L, Martin, NG, Goate, AM, Madden, PAF 2007, 'Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples', American Journal of Human Genetics, vol 80, no. 5, pp. 856-866.

Saunders, CL, Chiodini, BD, Sham, P, Öhman, M, Peltonen, L, Perola, M 2007, 'Meta-analysis of genome-wide linkage studies in BMI and obesity', Obesity, vol 15, no. 9, pp. 2263-2275.

Saxena, R, Voigt, BF, Lyssenko, V, Groop, L, Tuomi, T, Taskinen, M, Diabetes genetics initiative of broad institute of Harvard and MIT, Lund University, and Novartis institutes for BioMedical Research 2007, 'Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels', Science, vol 316, pp. 1331-1336.

Seppälä, E, Autio, V, Duggal, P, Ikonen, T, Stenman, U, Auvinen, A, Bailey-Wilson, J, Tammela, T, Schleutker, J 2007, 'KLF6 IVS1 -27G>A Variant and the Risk of Prostate Cancer in Finland', European Urology.

Setälä, K, Kallela, M, Valanne, L, Hernesniemi, J, Dashti, R, Pelaez, J, Färkkilä, M 2007, 'Idiopaattinen intrakraniaalinen hypertensio, »pseudotumor cerebri»', Duodecim, vol 123, no. 1, pp. 55-63.

Shtir, C, Nagakawa, IS, Duren, WL, Conneely, KN, Scott, LJ, Silander, K, Valle, TT, Tuomilehto, J, Buchanan, TA, Bergman, RN, Collins, FS, Boehnke, M, Watanabe, RM 2007, 'Subsets of finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q', Human Heredity, vol 63, no. 1, pp. 17-25.

Sihvola, E, Keski-Rahkonen, A, Dick, DM, Pulkkinen, L, Rose, RJ, Marttunen, M, Kaprio, J 2007, 'Minor depression in adolescence: Phenomenology and clinical correlates', Journal of Affective Disorders, vol 97, no. 1-3, pp. 211-218.

Siintola, E, Topcu, M, Aula, N, Lohi, H, Minassian, BA, Paterson, AD, Liu, X, Wilson, C, Lahtinen, U, Anttonen, A, Lehesjoki, A 2007, 'The novel neuronal ceroid lipofuscinosis gene MFSD8 encodes a putative lysosomal transporter', American Journal of Human Genetics, vol 81, no. 1, pp. 134-146.

Silventoinen, K, Pietiläinen, KH, Tynelius, P, Sørensen, TIA, Kaprio, J, Rasmussen, F 2007, 'Genetic and environmental factors in relative weight from birth to age 18: the Swedish young male twins study', International Journal of Obesity, vol 31, no. 4, pp. 615-621.

Silventoinen, K, Posthuma, D, Lahelma, E, Rose, RJ, Kaprio, J 2007, 'Genetic and environmental factors affecting self-rated health from age 16-25: A longitudinal study of Finnish twins', Behavior Genetics, vol 37, no. 2, pp. 326-333.

Skoog, T, Ahokas, K, Tiala, I, Pasonen-Seppanen, S, Tammi, R, Elomaa, O, Saarialho-Kere, U 2007, 'Matrix metalloproteinase-21 (MMP-21) expression is associated with differentiation and upregulated by retinoic acid in keratinocytes', Journal of investigative dermatology symposium proceedings., vol 127, pp. S80-S80.

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Smalley, SL, McGough, JJ, Moilanen, IK, Loo, SK, Taanila, A, Ebeling, H, Hurtig, T, Kaakinen, M, Humphrey, LA, McCracken, JT, Varilo, T, Yang, MH, Nelson, SF, Peltonen, L, Jaervelin, M 2007, 'Prevalence and psychiatric comorbidity of attention-deficit/hyperactivity disorder in an adolescent Finnish population', Journal of the American Academy of Child and Adolescent Psychiatry, vol 46, no. 12, pp. 1575-1583.

Soro-Paavonen, A, Naukkarinen, J, Lee-Rueckert, M, Watanabe, H, Rantala, E, Söderlund, S, Hiukka, A, Kovanen, PT, Jauhiainen, M, Peltonen, L, Taskinen, M 2007, 'Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL', Journal of Lipid Research, vol 48, no. 6, pp. 1409-1416.

Suna, T, Salminen, A, Soininen, P, Laatikainen, R, Ingman, P, Mäkelä, S, Savolainen, MJ, Hannuksela, ML, Jauhiainen, M, Taskinen, M, Kaski, K, Ala-Korpela, M 2007, '1H NMR metabonomics of plasma lipoprotein subclasses: elucidation of metabolic clustering by self-organising maps', NMR in Biomedicine, vol 20, no. 7, pp. 658-672.

Suomela, S, Kainu, K, Onkamo, P, Tiala, I, Himberg, J, Koskinen, L, Snellman, E, Karvonen, S, Karvonen, J, Uurasmaa, T, Reunala, T, Kivekäs, K, Jansen, C, Holopainen, PM, Elomaa, O, Kere, J, Saarialho-Kere, U 2007, 'Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis', Acta Dermato-Venereologica, vol 87, no. 2, pp. 127-134.

Sysi-Aho, M, Vehtari, A, Velagapudi, VR, Westerbacka, J, Yetukuri, L, Bergholm, R, Taskinen, M, Yki-Järvinen, H, Oresic, M 2007, 'Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles', Bioinformatics, vol 23, pp. i519-i528.

Taskinen, M 2007, 'Metabolic syndrome and dyslipidemia', Therapeutic research., vol 28, no. 8, pp. 1521-1532.

Taskinen, M 2007, 'The role of PPAR-[alpha] agonists in the prevention of CVD in diabetes', Current diabetes reports., vol 7, no. 2, pp. 83-85.

Tiainen, K, Pajala, S, Sipila, S, Kaprio, J, Koskenvuo, M, Alen, M, Heikkinen, E, Tolvanen, A, Rantanen, T 2007, 'Genetic effects in common on maximal walking speed and muscle performance in older women', Scandinavian Journal of Medicine & Science in Sports, vol 17, no. 3, pp. 274-280.

Tiala, I, Suomela, S, Huuhtanen, J, Wakkinen, J, Hölttä-Vuori, M, Kainu, K, Ranta, S, Turpeinen, U, Haemaelaeinen, E, Jiao, H, Karvonen, S, Ikonen, E, Kere, J, Saarialho-Kere, U, Elomaa, O 2007, 'The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes', Journal of Molecular Medicine, vol 85, no. 6, pp. 589-601.

Tikka-Kleemola, P, Hämäläinen, E, Tuomainen, K, Suvela, M, Artma, A, Kahre, O, Wessman, M, Palotie, A, Silander, K 2007, 'The enhancement of homogenous mass extension reaction: comparison of two enzymes', Molecular and Cellular Probes, vol 21, no. 3, pp. 216-221.

Turunen, JA, Peltonen, J, Pietiläinen, O, Hennah, W, Loukola, A, Paunio, T, Silander, K, Ekelund, J, Varilo, T, Partonen, T, Lönnqvist, J, Peltonen, L 2007, 'The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland', Schizophrenia Research, vol 91, no. 1-3, pp. 27-36.

Uusitalo, ALT, Vanninen, E, Levälahti, E, Battie, MC, Videman, T, Kaprio, J 2007, 'Role of genetic and environmental influences on heart rate variability in middle-aged men', American Journal of Physiology: Heart and Circulatory Physiology, vol 293, no. 2, pp. 1013-1022.

Videman, T, Battie, MC, Ripatti, SO, Jurvelin, J, Vanninen, E, Kaprio, J 2007, 'Determinants of changes in bone density: A 5-year follow-up study of adult male monozygotic twins', Journal of Clinical Densitometry, vol 10, no. 4, pp. 408-414.

Videman, T, Levälahti, E, Batti, MC, Simonen, R, Vanninen, E, Kaprio, J 2007, 'Heritability of BMD of femoral neck and lumbar spine: A multivariate twin study of Finnish men', Journal of Bone and Mineral Research, vol 22, no. 9, pp. 1455-1462.

Viken, RJ, Kaprio, J, Rose, RJ 2007, 'Genetic and environmental transmission of high-density alcohol use and alcohol problems: Parent offspring models', Behavior Genetics, vol 37, pp. 805-805.

Viken, RJ, Kaprio, J, Rose, RJ 2007, 'Personality at ages 16 and 17 and drinking problems at ages 18 and 25: Genetic analyses of data from FinnTwin16-25', Twin Research and Human Genetics, vol 10, no. 1, pp. 25-32.

Viljanen, A, Era, P, Kaprio, J, Pyykkö, I, Koskenvuo, M, Rantanen, T 2007, 'Genetic and environmental influences on hearing in older women', Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, vol 62, no. 4, pp. 447-452.

Viljanen, A, Kaprio, J, Pyykkö, I, Sorri, M, Kauppinen, M, Koskenvuo, M, Rantanen, T 2007, 'Genetic and environmental influences on hearing at different frequencies separately for the better and worse hearing ear in older women', International Journal of Audiology, vol 46, no. 12, pp. 772-779.

Vuoksimaa, EP, Tuulio-Henriksson, A, Hokkanen, L, Kaprio, J, Rose, RJ 2007, 'Mental rotation ability in same-sex and opposite-sex twins', Behavior Genetics, vol 37, pp. 806-806.

Waden, J, Thorn, LM, Forsblom, C, Lakka, T, Saraheimo, M, Rosengård-Bärlund, M, Heikkilä, O, Wessman, M, Turunen, JA, Parkkonen, M, Tikkanen, H, Groop, P 2007, 'Leisure-time physical activity is associated with the metabolic syndrome in type 1 diabetes', Diabetes Care, vol 30, no. 6, pp. 1618-1620.

Wang, J, Li, H, Kinnunen, L, Hu, G, Jarvinen, TM, Miettinen, ME, Yuan, S, Tuomilehto, J 2007, 'How well does the metabolic syndrome defined by five definitions predict incident diabetes and incident coronary heart disease in a Chinese population?', Atherosclerosis, vol 192, no. 1, pp. 161-168.

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Weedon, MN, Lettre, G, Freathy, RM, Lindgren, CM, Voight, BF, Perry, JRB, Elliott, KS, Hackett, R, Guiducci, C, Shields, B, Zeggini, E, Lango, H, Lyssenko, V, Timpson, NJ, Burtt, NP, Rayner, NW, Saxena, R, Ardlie, K, Tobias, JH, Ness, AR, Ring, SM, Palmer, CNA, Morris, AD, Peltonen, L, Salomaa, V, Davey Smith, G, Groop, L, Hattersley, AT, McCarthy, MI, Hirschhorn, JN, Frayling, TM 2007, 'A common variant of HMGA2 is associated with adult and childhood height in the general population', Nature Genetics, vol 39, no. 10, pp. 1245-1250.

Wessman, M, Terwindt, GM, Kaunisto, MA, Palotie, A, Ophoff, RA 2007, 'Migraine: a complex genetic disorder', Lancet Neurology, vol 6, pp. 521-532.

Winckler, W, Weedon, MN, Graham, RR, McCarroll, SA, Purcell, S, Almgren, P, Tuomi, T, Gaudet, D, Bengtsson Boström, K, Walker, M, Hitman, G, Hattersley, AT, McCarthy, MI, Ardlie, KG, Hirschhorn, JN, Daly, MJ, Frayling, TM, Groop, L, Altshuler, D 2007, 'Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes', Diabetes, vol 56, pp. 685-693.

Zhang, P, Kerkela, E, Skottman, H, Levkov, L, Kivinen, K, Lahesmaa, R, Hovatta, O, Kere, J 2007, 'Distinct sets of developmentally regulated genes that are expressed by human oocytes and human embryonic stem cells', Fertility and Sterility : official journal of the American Fertility Society , vol 2007, no. 87, pp. 677-690.

2008 Abdel-Rahman, WM, Kalinina, J, Shoman, S, Eissa, S, Ollikainen, M, Elomaa, O, Eliseenkova, AV, Butzow, R, Mohammadi, M, Peltomäki, P 2008, 'Somatic FGF9 mutations in colorectal and endometrial carcinomas associated with membranous [beta]-catenin', Human Mutation, vol 29, no. 3, pp. 390-397.

Adiels, M, Taskinen, M, Boren, J 2008, 'Fatty liver, insulin resistance, and dyslipidemia', Current diabetes reports., vol 8, pp. 60-64.

Adiels, M, Olofsson, S, Taskinen, M, Boren, J 2008, 'Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 28, pp. 1225-1236.

Agrawal, A, Pergadia, ML, Saccone, SF, Lynskey, MT, Wang, JC, Martin, NG, Statham, D, Henders, A, Campbell, M, Garcia, R, Broms, U, Todd, RD, Goate, AM, Rice, J, Kaprio, J, Heath, AC, Montgomery, GW, Madden, PAF 2008, 'An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project', Archives of General Psychiatry, vol 65, no. 6, pp. 713-722.

Alimohammadi, M, Björklund, P, Hallgren, Å, Pöntynen, N, Szinnai, G, Shikama, N, Keller, MP, Ekwall, O, Kinkel, SA, Husebye, ES, Gustafsson, J, Rorsman, F, Peltonen, L, Betterle, C, Perheentupa, J, Åkerström, G, Westin, G, Scott, HS, Holländer, GA, Kämpe, O 2008, 'Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen', New England Journal of Medicine, vol 358, no. 10, pp. 1018-1028.

Anttila, V, Nyholt, DR, Kallela, M, Artto, V, Vepsäläinen, S, Jakkula, E, Wennerström, A, Tikka-Kleemola, P, Kaunisto, MA, Hämäläinen, E, Widen, E, Terwilliger, J, Merikangas, K, Montgomery, GW, Martin, NG, Daly, M, Kaprio, J, Peltonen, L, Färkkilä, M, Wessman, M, Palotie, A 2008, 'Consistently replicating locus linked to migraine on 10q22-q23', American Journal of Human Genetics, vol 82, no. 5, pp. 1051-1063.

Aubertin-Leheudre, M, Koskela, A, Marjamaa, A, Adlercreutz, H 2008, 'Plasma alkylresorcinols and urinary alkylresorcinol metabolites as biomarkers of cereal fiber intake in Finnish women', Cancer Epidemiology, Biomarkers & Prevention, vol 17, no. 9, pp. 2244-2248.

Auro, K, Kristiansson, K, Zethelius, B, Berne, C, Lannfelt, L, Taskinen, M, Jauhiainen, M, Perola, M, Peltonen, L, Syvänen, A 2008, 'USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study', Diabetologia, vol 51, no. 3, pp. 464-472.

Bachman, P, Kim, J, Yee, CM, Therman, S, Manninen, M, Lönnqvist, J, Kaprio, J, Huttunen, MO, Näätänen, R, Cannon, TD 2008, 'Abnormally high EEG alpha synchrony during working memory maintenance in twins discordant for schizophrenia', Schizophrenia Research, vol 103, no. 1-3, pp. 293-297.

Battie, MC, Levalahti, E, Videman, T, Burton, K, Kaprio, J 2008, 'Heritability of lumbar flexibility and the role of disc degeneration and body weight', Journal of Applied Physiology, vol 104, no. 2, pp. 379-385.

Battie, MC, Videman, T, Levalahti, E, Gill, K, Kaprio, J 2008, 'Genetic and Environmental Effects on Disc Degeneration by Phenotype and Spinal Level A Multivariate Twin Study', Spine, vol 33, no. 25, pp. 2801-2808.

Benyamin, B, Perola, M, Cornes, BK, Madden, PAF, Palotie, A, Nyholt, DR, Montgomery, GW, Peltonen, L, Martin, NG, Visscher, PM 2008, 'Within-family outliers: segregating alleles or environmental effects? A linkage analysis of height from 5815 sibling pairs', European Journal of Human Genetics, vol 16, pp. 516-524.

Bidel, S, Silventoinen, K, Hu, G, Lee, D, Kaprio, J, Tuomilehto, J 2008, 'Coffee consumption, serum gamma-glutamyltransferase and risk of type II diabetes', European Journal of Clinical Nutrition, vol 62, no. 2, pp. 178-185.

Broms, U, Korhonen, T, Kaprio, J 2008, 'Smoking reduction predicts cessation: Longitudinal evidence from the Finnish adult twin cohort', Nicotine & Tobacco Research, vol 10, no. 3, pp. 423-427.

Bruce, S, Lindgren, CM, Lipsanen-Nyman, M, Kere, J, Hannula-Jouppi, K 2008, 'Restriction site-specific methylation studies of imprinted genes with quantitative real-time PCR', Clinical Chemistry (Washington, DC), vol 54, no. 3, pp. 491-499.

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Cervin, C, Lyssenko, V, Bakhtadze, E, Lindholm, E, Nilsson, P, Tuomi, T, Cilio, CM, Groop, L 2008, 'Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes', Diabetes, vol 57, no. 5, pp. 1433- 1437.

Dominicus, A, Ripatti, S, Pedersen, NL, Palmgren, J 2008, 'A random change point model for assessing variability in repeated measures of cognitive function', Statistics in Medicine, vol 27, pp. 5786-5798.

Dominicus, A, Ripatti, SO, Pedersen, N, Palmgren, J 2008, 'Modelling Variability in Longitudinal Data Using Random Change Point Models', Statistics in Medicine, vol 2008/7, no. 27, pp. 5786-98.

Donner, J, Pirkola, S, Silander, K, Kananen, L, Terwilliger, J, Lönnqvist, J, Peltonen, L, Hovatta, I 2008, 'An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders', Biological Psychiatry, vol 64, no. 8, pp. 672-680.

Dorkhan, M, Tripathy, D, Malm, G, Asgharian, H, Tuomi, T, Groop, L 2008, 'Independent measures of insulin secretion and insulin sensitivity during the same test: the glucagon-insulin tolerance test', Journal of Internal Medicine, vol 264, no. 1, pp. 62-71.

Drögemuller, C, Karlsson, EK, Hytönen, MK, Perloski, M, Dolf, G, Sainio, K, Lohi, H, Lindblad-Toh, K, Leeb, T 2008, 'A mutation in hairless dogs implicates FOXI3 in ectodermal development', Science, vol 321, no. 5895, pp. 1462.

El-Metwally, A, Mikkelsson, M, Stahl, M, Macfarlane, GJ, Jones, GT, Pulkkinen, L, Rose, RJ, Kaprio, J 2008, 'Genetic and environmental influences on non-specific low back pain in children: a twin study', European Spine Journal, vol 17, no. 4, pp. 502-508.

Enattah, NS, Jensen, T, Nielsen, M, Lewinski, R, Kuokkanen, M, Rasinperä, H, El-Shanti, H, Seo, JK, Alifrangis, M, Khalil, I, Natah, A, Ali, A, Natah, S, Comas, D, Mehdi, Q, Groop, L, Vestergaard, EM, Imtiaz, F, Rashed, M, Meyer, B, Troelsen, J, Peltonen, L, Ettanah, NS 2008, 'Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture', American Journal of Human Genetics, vol 82, no. 1, pp. 57-72.

Estlander, A, Knaster, P, Karlsson, H, Kaprio, JA, Kalso, E 2008, 'Pain intensity influences the relationship between anger management style and depression', Pain : the journal of the International association for the study of pain, vol 140, no. 2, pp. 387-392.

Finnon, P, Robertson, N, Dziwura, S, Raffy, C, Zhang, W, Ainsbury, L, Kaprio, J, Badie, C, Bouffler, S 2008, 'Evidence for significant heritability of apoptotic and cell cycle responses to ionising radiation', Journal of human genetics., vol 123, no. 5, pp. 485-493.

Gong, X, Bacchelli, E, Blasi, F, Toma, C, Betancur, C, Chaste, P, Delorme, R, Durand, CM, Fauchereau, F, Botros, HG, Leboyer, M, Mouren-Simeoni, M, Nygren, G, Anckarsater, H, Rastam, M, Gillberg, IC, Gillberg, C, Moreno-De-Luca, D, Carone, S, Nummela, I, Rossi, M, Battaglia, A, Jarvela, I, Maestrini, E, Bourgeron, T, Rossi, M, Järvelä, I, International Molecular Genetic Study of Autism Consortium (IMGSAC) 2008, 'Analysis of X chromosome inactivation in autism spectrum disorders', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 147B, no. 6, pp. 830-835.

Graner, M, Kahri, J, Varpula, M, Salonen, RM, Nyyssönen, K, Jauhiainen, M, Nieminen, MS, Syvänne, M, Taskinen, M 2008, 'Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease', Nutrition, Metabolism and Cardiovascular Diseases, vol 18, pp. 271-277.

Grisoni, M, Proust, C, Alanne, M, DeSuremain, M, Salomaa, V, Kuulasmaa, K, Cambien, F, Nicaud, V, Stegmayr, B, Virtamo, J, Shields, D, Kee, F, Tiret, L, Evans, A, Tregouet, D, Peltonen, L, MORGAM Project 2008, 'Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project', European Journal of Human Genetics, vol 16, pp. 1512-1520.

Guan, W, Pluzhnikov, A, Cox, NJ, Boehnke, M, Tuomi, T, International Type 2 Diabetes Linkage Analysis Consortium 2008, 'Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium', Human Heredity, vol 66, no. 1, pp. 35-49.

Hackman, P, Hollo, S, Luque, H, Tokola, M, Kere, J, Edstrom, L, Ahlberg, G, Udd, B 2008, 'Welander distal myopathy: The evasive gene', Neuromuscular Disorders, vol 18, pp. 767-767.

Hallast, P, Saarela, J, Palotie, A, Laan, M 2008, 'High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes', BMC Evolutionary Biology, vol 8, no. 195.

Hallast, P, Saarela, J, Palotie, A, Laan, M 2008, 'High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes', BMC Evolutionary Biology, vol 2008/8, pp. 195-209.

Hannelius, U, Salmela, E, Lappalainen, T, Guillot, G, Lindgren, CM, von Döbeln, U, Lahermo, P, Kere, J 2008, 'Population substructure in Finland and Sweden revealed by the use of spatial coordinates and a small number of unlinked autosomal SNPs', BMC Genetics, vol 9, no. 54.

Hannukainen, JC, Nuutila, P, Ronald, B, Kaprio, J, Kujala, UM, Janatuinen, T, Heinonen, OJ, Kapanen, J, Viljanen, T, Haaparanta, M, Ronnemaa, T, Parkkola, R, Knuuti, J, Kalliokoski, KK 2008, 'Increased physical activity decreases hepatic free fatty acid uptake: a study in human monozygotic twins (vol 578, pg 347, 2007)', Journal of Physiology, vol 586, pp. 311-311.

Harkonmaki, K, Silventoinen, K, Levalahti, E, Pitkaniemi, J, Huunan-Seppala, A, Klaukka, T, Koskenvuo, M, Kaprio, J 2008, 'The Genetic Liability to Disability Retirement: A 30-Year Follow-Up Study of 24,000 Finnish Twins', PLoS One, vol 10, no. e3402, pp. e3402.

Hartman, M, Hall, P, Edgren, G, Reilly, M, Lindstrom, L, Lichtenstein, P, Kaprio, J, Skytthe, A, Peto, J, Czene, K 2008, 'Breast cancer onset in twins and women with bilateral disease', Journal of Clinical Oncology, vol 26, no. 25, pp. 4086-4091.

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Heikkilä, O, Lundbom, N, Timonen, M, Groop, P, Heikkinen, S, Mäkimattila, S 2008, 'Risk for metabolic syndrome predisposes to alterations in the thalamic metabolism', Metabolic Brain Disease, vol 23, no. 3, pp. 315-324.

Heikkinen, M, Pajukanta, R, Pitkäniemi, J, Broms, U, Sorsa, T, Koskenvuo, M, Meurman, JH 2008, 'The effect of smoking on periodontal health of 15- to 16-year-old adolescents', Journal of Periodontology, vol 79, no. 11, pp. 2042-2047.

Heinonen-Guzejev, M, Vuorinen, HS, Mussalo-Rauhamaa, H, Heikkilä, KV, Koskenvuo, M, Kaprio, J 2008, 'Genetic component of noise sensitivity (vol 8, pg 245, 2005)', Twin Research and Human Genetics, vol 11, pp. II-II.

Hemila, H, Kaprio, J 2008, 'Vitamin E supplementation and pneumonia risk in males who initiated smoking at an early age: effect modification by body weight and dietary vitamin C', Nutrition Journal, vol 7, no. 33.

Hemilä, H, Kaprio, J 2008, 'Vitamin E supplementation may transiently increase tuberculosis risk in males who smoke heavily and have high dietary vitamin C intake', British Journal of Nutrition, vol 100, no. 4, pp. 896-902.

Hiukka, A, Westerbacka, J, Leinonen, ES, Watanabe, H, Wiklund, O, Mattson Hulten, L, Salonen, JT, Tuomainen, T, Yki-Järvinen, H, Keech, AC, Taskinen, M 2008, 'Long-term effects of fenofibrate on carotid intima-media thickness and augmentation index in subjects with type 2 diabetes mellitus', Journal of the American College of Cardiology, vol 52, pp. 2190-2197.

Hjelmborg, JVB, Fagnani, C, Silventoinen, K, McGue, M, Korkeila, M, Christensen, K, Rissanen, A, Kaprio, J 2008, 'Genetic influences on growth traits of BMI: A longitudinal study of adult twins', Obesity, vol 16, no. 4, pp. 847-852.

Holmkvist, J, Almgren, P, Lyssenko, V, Lindgren, CM, Eriksson, K, Isomaa, B, Tuomi, T, Nilsson, P, Groop, L 2008, 'Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes', Diabetes, vol 57, no. 6, pp. 1738-1744.

Huertas-Vazquez, A, Plaisier, C, Weissglas-Volkov, D, Sinsheimer, JS, Canizales-Quinteros, S, Cruz-Bautista, I, Tusie-Luna, T, Taskinen, M, Aguilar-Salinas, C, Pajukanta, P 2008, 'TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia', Diabetologia, vol 51, no. 1, pp. 62-69.

Huizink, AC, Bartels, M, Rose, RJ, Pulkkinen, L, Eriksson, CJP, Kaprio, J 2008, 'Chernobyl exposure as stressor during pregnancy and hormone levels in adolescent offspring', Journal of epidemiology and community health, vol 62, no. e5.

Hur, Y, Kaprio, J, Iacono, WG, Boomsma, DI, McGgue, M, Silventoinen, K, Martin, NG, Luciano, M, Visscher, PM, Rose, RJ, He, M, Ando, J, Ooki, S, Nonaka, K, Lin, CCH, Lajunen, HR, Cornes, BK, Bartels, M, van Beijsterveldt, CEM, Cherny, SS, Mitchell, K 2008, 'Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins', International Journal of Obesity, vol 32, no. 10, pp. 1455-1467.

Hässler, S, Peltonen, L, Sandler, S, Winqvist, O 2008, 'Aire deficiency causes increased susceptibility to streptozotocin-induced murine type 1 diabetes', Scandinavian Journal of Immunology, vol 67, no. 6, pp. 569-580.

Ihalmo, P, Wessman, M, Kaunisto, MA, Kilpikari, R, Parkkonen, M, Forsblom, CM, Holthöfer, H, Groop, P, Kaunisto, MA, Forsblom, C, FinnDiane Study Group 2008, 'Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy', Diabetologia, vol 51, no. 1, pp. 86-90.

Immonen, T, Alakuijala, A, Hytönen, M, Sainio, K, Poteryaev, D, Saarma, M, Pasternack, M, Sariola, H 2008, 'A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus', Experimental Neurology, vol 210, pp. 793-796.

Jakkula, E, Rehnström, K, Varilo, T, Pietiläinen, O, Paunio, T, Pedersen, N, deFaire, U, Järvelin, M, Saharinen, J, Freimer, N, Ripatti, S, Purcell, S, Collins, A, Daly, M, Palotie, A, Peltonen, L 2008, 'The genome-wide patterns of variation expose significant substructure in a founder population', American Journal of Human Genetics, vol 83, no. 12, pp. 787-794.

Jarvinen, TM, Zucchelli, M, Hellquist, A, Berglind, L, Koskenmies, S, Panelius, I, Hasan, T, Julkunen, HA, Kere, J, Saarialho-Kere, U 2008, 'Finnish patients with systemic lupus erythematosus share predisposing genetic risk factors with other populations', Journal of investigative dermatology symposium proceedings. , vol 128, pp. S113-S113.

Jiao, H, Toth, B, Erdos, M, Fransson, I, Rakoczi, E, Balogh, I, Magyarics, Z, Derfalvi, B, Csorba, G, Szaflarska, A, Megarbane, A, Akatcherian, C, Dbaibo, G, Rajnavoelgyi, E, Hammarstrom, L, Kere, J, Lefranc, G, Marodi, L 2008, 'Novel and recurrent STAT3 mutations in hyper-IgE syndrome patients from different ethnic groups', Molecular Immunology, vol 2008, no. 46, pp. 202-206.

Jiao, H, Kaaman, M, Dungner, E, Kere, J, Arner, P, Dahlman, I 2008, 'Association analysis of positional obesity candidate genes based on integrated data from transcriptomics and linkage analysis', International Journal of Obesity, vol 2008, no. 32, pp. 816-825.

Joensuu, EI, Abdel-Rahman, WM, Ollikainen, M, Ruosaari, S, Knuutila, S, Peltomäki, P 2008, 'Epigenetic signatures of familial cancer are characteristic of tumor type and family category', Cancer Research, vol 68, no. 12, pp. 4597-4605.

Juurinen, L, Kotronen, A, Graner, M, Yki-Järvinen, H 2008, 'Rosiglitazone reduces liver fat and insulin requirements and improves hepatic insulin sensitivity and glycemic control in patients with type 2 diabetes requiring insulin doses', Journal of Clinical Endocrinology and Metabolism, vol 93, pp. 118-124.

Järvinen, T, Harjutsalo, V, Kinnunen, L, Miettinen, ME, Tuomilehto-Wolf, E, Tuomilehto, J 2008, 'A population-specific diabetogenic haplotype HLA-A2, Cw1, B56, DR4, DQ8 is associated with high birthweight in Finnish diabetic families', Genes and Immunity, vol 9, no. 3, pp. 207-213.

Kallela, M 2008, 'Akuutti päänsärky', Suomen lääkärilehti , vol 63, no. 39, pp. 3179-3183.

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Kathiresan, S, Melander, O, Guiducci, C, Surti, A, Burtt, NP, Rieder, MJ, Cooper, GM, Roos, C, Voight, BF, Havulinna, AS, Wahlstrand, B, Hedner, T, Corella, D, Tai, ES, Ordovas, JM, Berglund, G, Vartiainen, E, Jousilahti, P, Hedblad, B, Taskinen, M, Newton-Cheh, C, Salomaa, V, Peltonen, L, Groop, L, Altshuler, DM, Orho-Melander, M 2008, 'Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans', Nature Genetics, vol 40, no. 2, pp. 189-197.

Kaurijoki, S, Kuikka, JT, Niskanen, E, Carlson, S, Pietiläinen, KH, Pesonen, U, Kaprio, J, Rissanen, A, Tiihonen, J, Karhunen, L 2008, 'Association of serotonin transporter promoter regulatory region polymorphism and cerebral activity to visual presentation of food', Clinical Physiology and Functional Imaging, vol 28, no. 4, pp. 270-276.

Kaurijoki , S, Kuikka, JT, Niskanen, E, Carslon, S, Pietiläinen, KH, Pesonen, U, Kaprio, J, Rissanen, A, Tiihonen, J, Karhunen, L 2008, 'Association of serotonin transporter promoter regulatory region polymorphism and crebral activity to visual presentation of food', Clinical Physiology and Functional Imaging, vol 28, no. 4, pp. 270-276.

Kennedy, LJ, O'Neill, T, House, A, Barnes, A, Kyöstilä, K, Innes, J, Fretwell, N, Day, MJ, Catchpole, B, Lohi, H, Ollier, WE 2008, 'Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex', Tissue Antigens, vol 71, no. 1, pp. 51-56.

Keskitalo, K, Silventoinen, K, Tuorila, H, Perola, M, Pietiläinen, KH, Rissanen, A, Kaprio, J 2008, 'Genetic and environmental contributions to food use patterns of young adult twins', Physiology & Behavior, vol 93, no. 1-2, pp. 235-242.

Keskitalo, K, Tuorila, H, Spector, TD, Cherkas, LF, Knaapila, A, Kaprio, J, Silventoinen, K, Perola, M 2008, 'The Three-Factor Eating Questionnaire, body mass index, and responses to sweet and salty fatty foods: a twin study of genetic and environmental associations', American Journal of Clinical Nutrition, vol 88, no. 2, pp. 263-271.

Kilpinen, H, Ylisaukko-oja, T, Hennah, W, Palo, O, Varilo, T, Vanhala, R, Nieminen- von Wendt, T, Wendt, LV, Paunio, T, Peltonen, L 2008, 'Association of DISC1 with autism and Asperger syndrome', Molecular Psychiatry, vol 13, no. 2, pp. 187-196.

Kinnunen, T, Korhonen, T, Garvey, AJ 2008, 'Role of nicotine gum and pretreatment depressive symptoms in smoking cessation: twelve-month results of a randomized placebo controlled trial', International Journal of Psychiatry in Medicine, vol 38, no. 3, pp. 373-389.

Kinnunen, T, Leeman, RF, Korhonen, T, Quiles, ZN, Terwal, DM, Garvey, AJ, Hartley, HL 2008, 'Exercise as an adjunct to nicotine gum in treating tobacco dependence among women', Nicotine & Tobacco Research, vol 10, no. 4, pp. 689-703.

Knaapila, A, Tuorila, H, Kyvik, KO, Wright, MJ, Keskitalo, K, Hansen, J, Kaprio, J, Perola, M, Silventoinen, K 2008, 'Self-ratings of olfactory function reflect odor annoyance rather than olfactory acuity', Laryngoscope, vol 118, no. 12, pp. 2212-2217.

Knaapila, A, Tuorila, H, Silventoinen, K, Wright, MJ, Kyvik, KO, Cherkas, LF, Keskitalo, K, Hansen, J, Martin, NG, Spector, TD, Kaprio, J, Perola, M 2008, 'Genetic and environmental contributions to perceived intensity and pleasantness of androstenone odor: an international twin study', Chemosensory perception., vol 1, no. 1, pp. 34-42.

Knaapila, A, Tuorila, H, Silventoinen, K, Wright, MJ, Kyvik, KO, Keskitalo, K, Hansen, J, Kaprio, J, Perola, M 2008, 'Environmental effects exceed genetic effects on perceived intensity and pleasantness of several odors: a three-population twin study', Behavior Genetics, vol 38, no. 5, pp. 484-492.

Korhonen, T, Huizink, AC, Dick, DM, Pulkkinen, L, Rose, RJ, Kaprio, J 2008, 'Role of individual, peer and family factors in the use of cannabis and other illicit drugs: A longitudinal analysis among Finnish adolescent twins', Drug and Alcohol Dependence, vol 97, no. 1-2, pp. 33-43.

Koskela, AK, Kaurijoki, S, Pietiläinen, KH, Karhunen, L, Pesonen, U, Kuikka, JT, Kaprio, J, Rissanen, A 2008, 'Serotonin transporter binding and acquired obesity: an imaging study of monozygotic twin pairs', Physiology & Behavior, vol 93, no. 4-5, pp. 724-732.

Koskela, A, Kauppinen, T, Keski-Rahkonen, A, Sihvola, E, Kaprio, J, Rissanen, A, Ahonen, A 2008, 'Brain serotonin transporter binding of [I-123]ADAM: Within-subject variation between summer and winter data: within-subject variation between summer and winter data', Chronobiology International, vol 25, no. 5, pp. 657-665.

Koskinen, L, Korponay-Szabo, I, Viiri, K, Juuti-Uusitalo, K, Kaukinen, K, Lindfors, K, Mustalahti, K, Kurppa, K, Adany, R, Pocsai, Z, Szeles, G, Einarsdottir, E, Wijmenga, C, Mäki, M, Partanen, J, Kere, J, Saavalainen, P 2008, 'Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association', Journal of Medical Genetics, vol 45, no. 4, pp. 222-227.

Kotronen, A, Juurinen, L, Tiikkanen, M, Vehkavaara, S, Yki-Järvinen, H 2008, 'Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes', Gastroenterology, vol 135, no. 1, pp. 122-130.

Kotronen, A, Juurinen, L, Hakkarainen, A, Westerbacka, J, Corner, A, Bergholm, R, Yki-Järvinen, H 2008, 'Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects', Diabetes Care, vol 31, no. 1, pp. 165-169.

Kristiansson, K, Ilveskoski, E, Lehtimäki, T, Peltonen, L, Perola, M, Karhunen, PJ 2008, 'Association analysis of allelic variants of USF1 in coronary atherosclerosis', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 28, no. 5, pp. 983-989.

Kristiansson, K, Naukkarinen, J, Palotie, L 2008, 'Isolated populations and complex disease gene identification', Genome Biology, vol 9, no. 8, 109, 9 s.

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Kristjansdottir, G, Sandling, G, Bonetti, A, Roos, I, Milani , L, Wang, C, Gustafsdottir, S, Sigurdsson, S, Lundmark, A, Tienari, P, Koivisto, K, Elovaara, I, Pirttilä, T, Reunanen, M, Palotie, L, Saarela, J, Hillert, J, Olsson, T, Landegren, U, Alcina, A, Fernández, O, Leyva, L, Guerrero, M, Lucas, M, Izquierdo, G, Matesanz, F, Syvänen, A 2008, 'Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations', Journal of Medical Genetics, vol 45, no. 6, pp. 362-369.

Kronholm, E, Partonen, T, Laatikainen, T, Peltonen, M, Harma, M, Hublin, C, Kaprio, J, Aro, AR, Partinen, M, Fogelholm, M, Valve, R, Vahtera, J, Oksanen, T, Kivimäki, M, Koskenvuo, M, Sutela, H 2008, 'Trends in self-reported sleep duration and insomnia-related symptoms in Finland from 1972 to 2005: a comparative review and re-analysis of Finnish population samples', Journal of Sleep Research, vol 17, no. 1, pp. 54-62.

Kumpula, LS, Kumpula, JM, Taskinen, M, Jauhiainen, M, Kaski, K, Ala-Korpela, M 2008, 'Reconsideration of hydrophobic lipid distributions in lipoprotein particles', Chemistry and Physics of Lipids, vol 155, pp. 57-62.

Kuoppamaa, H, Skrobuk, P, Sihvo, M, Hiukka, A, Chibalin, AV, Zierath, JR, Koistinen, HA 2008, 'Globular adiponectin stimulates glucose transport in type 2 diabetic muscle', Diabetes - Metabolism: Research and Reviews (Print Edition), vol 24, no. 7, pp. 554-564.

Kuusisto, H, Kaprio, J, Kinnunen, E, Luukkaala, T, Koskenvuo, M, Elovaara, I 2008, 'Concordance and heritability of multiple sclerosis in Finland: study on a nationwide series of twins', European Journal of Neurology, vol 15, no. 10, pp. 1106-1110.

Lahtinen, AM, Lehtonen, A, Kaartinen, M, Toivonen, L, Swan, H, Widen, E, Lehtonen, E, Lehto, VP, Kontula, K 2008, 'Plakophilin-2 missense mutations in arrhythmogenic right ventricular cardiomyopathy', International Journal of Cardiology, vol vol 126, no. 1, pp. 92-100.

Laitala, VS, Kaprio, J, Silventoinen, K 2008, 'Genetics of coffee consumption and its stability', Addiction, vol 103, no. 12, pp. 2054-2061.

Lappalainen, T, Laitinen, V, Salmela, E, Andersen, P, Huoponen, K, Savontaus, M, Lahermo, P 2008, 'Migration waves to the Baltic Sea region', Annals of Human Genetics, vol 72, no. Pt 3, pp. 337-348.

Lappalainen, M, Paavola-Sakki, P, Halme, L, Turunen, U, Färkkilä, M, Repo, H, Kontula, K 2008, 'Novel CARD15/NOD2 mutations in Finnish patients with Crohn's disease and their relation to phenotypic variation in vitro and in vivo', Inflammatory Bowel Diseases, vol 14, no. 2, pp. 176-185.

Lappalainen, M, Halme, L, Turunen, U, Saavalainen, P, Einarsdottir, E, Färkkilä, M, Kontula, K, Paavola-Sakki, P 2008, 'Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population', Inflammatory Bowel Diseases, vol 14, no. 8, pp. 1118-1124.

Laskibar, I, Ortega-Alonso, A, Pajala, S, Urdaneta, E, Yanguas, J, Kaprio, J, Rantanen, T 2008, 'Effect of consistent physical activity since midlife and educational history on dual task performance in older women', Journal of Aging and Physical Activity, vol 16, pp. S199-S200.

Latendresse, SJ, Rose, RJ, Viken, RJ, Pulkkinen, L, Kaprio, J, Dick, DM 2008, 'Parenting mechanisms in links between parents' and adolescents' alcohol use behaviors', Alcoholism: Clinical and Experimental Research, vol 32, pp. 322-330.

Lee, JC, Weissglas-Volkov, D, Kyttälä, M, Dastani, Z, Cantor, RM, Sobel, EM, Plaisier, CL, Engert, JC, van Greevenbroek, MMJ, Kane, JP, Malloy, MJ, Pullinger, CR, Huertas-Vazquez, A, Aguilar-Salinas, CA, Tusie-Luna, T, Bruin, TWAD, Aouizerat, BE, van der Kallen, CCJ, Croce, CM, Aqeilan, RI, Marcil, M, Viikari, JSA, Lehtimäki, T, Raitakari, OT, Kuusisto, J, Laakso, M, Taskinen, M, Genest, J, Pajukanta, P 2008, 'WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels', American Journal of Human Genetics, vol 83, pp. 180-192.

Lehtokari, V, Pelin, K, Donner, K, Voit, T, Rudnik-Schöneborn, S, Stoetter, M, Talim, B, Topaloglu, H, Laing, NG, Wallgren-Pettersson, C 2008, 'Identification of a founder mutation in TPM3 in nemaline myopathy patients of Turkish origin', European Journal of Human Genetics, vol 16, no. 9, pp. 1055-1061.

Lettre, G, Jackson, AU, Gieger, C, Groop, LC, Peltonen, L 2008, 'Identification of ten loci associated with height highlights new biological pathways in human growth', Nature Genetics, vol 40, no. 5, pp. 584-591.

Lindh, E, Lind, SM, Lindmark, E, Hässler, S, Perheentupa, J, Peltonen, L, Winqvist, O, Karlsson, MI 2008, 'AIRE regulates T-cell-independent B-cell responses through BAFF', Proceedings of the National Academy of Sciences of the United States of America, vol 105, no. 47, pp. 18466-18471.

Lorentzen, AR, Smestad, C, Lie, BA, Oturai, AB, Akesson, E, Saarela, J, Myhr, K, Vartdal, F, Celius, EG, Sorensen, PS, Hillert, J, Spurkland, A, Harbo, HF 2008, 'The SH2D2A gene and susceptibility to multiple sclerosis', Journal of Neuroimmunology, vol 197, pp. 152-158.

Lorentzen, AR, Smestad, C, Lie, BA, Oturai, AB, Akesson, E, Saarela, J, Myhr, KM, Vartdal, F, Celius, EG, Soresen, PS, Hillert, J, Spurkland, A, Harbo, HF 2008, 'The SH2D2A gene and susceptibility to multiple sclerosis', Journal of Neurology, Neurosurgery and Psychiatry, vol 79, pp. 345-345.

Loukola, A, Broms, U, Maunu, H, Widen, E, Heikkilä, K, Siivola, M, Salo, A, Pergadia, ML, Nyman, E, Sammalisto, S, Perola, M, Agrawal, A, Heath, AC, Martin, NG, Madden, PAF, Palotie, L, Kaprio, J 2008, 'Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background', Pharmacogenomics Journal, vol 8, no. 3, pp. 209-219.

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Lu, AT, Ogdie, MN, Järvelin, M, Moilanen, I, Loo, SK, McCracken, J, McGough, J, Yang, M, Peltonen, L, Nelson, SF, Cantor, RM, Smalley, SL 2008, 'Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 147B, no. 8, pp. 1488-1494.

Ludwig, KU, Schumacher, J, Schulte-Koerne, G, Koenig, IR, Warnke, A, Plume, E, Anthoni, H, Peyrard-Janvid, M, Meng, H, Ziegler, A, Remschmidt, H, Kere, J, Gruen, JR, Mueller-Myhsok, B, Noethen, MM, Hoffmann, P 2008, 'Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample', Psychiatric Genetics, vol 2008, no. 18, pp. 310-312.

Lundmark, PE, Liljedahl, U, Boomsma, DI, Mannila, H, Martin, NG, Palotie, A, Peltonen, L, Perola, M, Spector, TD, Syvänne, A 2008, 'Evaluation of HapMap data in six populations of European descent', European Journal of Human Genetics, vol 16, no. 9, pp. 1142-1150.

Lyssenko, V, Jonsson, A, Almgren, P, Pulizzi, N, Isomaa, B, Tuomi, T, Berglund, G, Altshuler, D, Nilsson, P, Groop, L 2008, 'Clinical risk factors, DNA variants, and the development of type 2 diabetes', New England Journal of Medicine, vol 359, no. 21, pp. 2220-2232.

Lyssenko, V, Sjögren, M, Almgren, P, Anevski, D, Orho-Melander, M, Isomaa, B, Tuomi, T, Taskinen, M, Groop, L 2008, 'Genetic prediction of the metabolic syndrome', Diabetes & Metabolic Syndrome: clinical research & reviews., vol 2, no. 4, pp. 245-252.

Magnusson, PKE, Boman, M, de Faire, U, Perola, M, Peltonen, L, Pedersen, NL 2008, 'Genome-wide search for QTLs for apolipoprotein A-I level in elderly Swedish DZ twins: evidence of female-specific locus on 15q11-13', European Journal of Human Genetics, vol 16, no. 9, pp. 1103-1110.

Manty, M, Heinonen, A, Viljanen, A, Pajala, S, Kaprio, J, Rantanen, T 2008, 'SELF-REPORTED PRECLINICAL MOBILITY LIMITATION AND FALL HISTORY AS PREDICTORS OF FALLS IN OLDER HIGH-FUNCTIONING WOMEN', Gerontologist, vol 48, pp. 101-101.

Melen, E, Nyberg, F, Lindgren, CM, Berglind, N, Zucchelli, M, Nordling, E, Hallberg, J, Svartengren, M, Morgenstern, R, Kere, J, Bellander, T, Wickman, M, Pershagen, G 2008, 'Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease', Environmental Health Perspectives, vol 2008, no. 116, pp. 1077-1084.

Mikkola, TM, Sipilae, S, Rantanen, T, Sievaenen, H, Suominen, H, Kaprio, J, Koskenvuo, M, Kauppinen, M, Heinonen, A 2008, 'Genetic and environmental influence on structural strength of weight-bearing and non-weight-bearing bone: A twin study', Journal of Bone and Mineral Research, vol 23, pp. 492-498.

Mikkola, TM, Heinonen, A, Kovanen, V, Cheng, S, Kujala, UM, Suominen, H, Alen, M, Puolakka, J, Ronkainen, P, Koskenvuo, M, Kaprio, J, Rantanen, T, Sipila, S 2008, 'The Influence of Long-Term Hormone Replacement Therapy on Tibia Bone Mineral Mass and Mass Distribution in Postmenopausal Women', Journal of Bone and Mineral Research, vol 23, pp. S124-S124.

Miljutin, A, Lehtonen, JT 2008, 'Probability of competition between introduced and native rodents in Madagascar: an estimation based on morphological traits', Estonian journal of ecology., vol 57, no. 2, pp. 133-152.

Moren, X, Deakin, S, Liu, M, Taskinen, M, James, RW 2008, 'HDL subfraction distribution of paraoxonase- 1 and its relevance to enzyme activity and resistance to oxidative stress', Journal of Lipid Research, vol 49, pp. 1246-1253.

Mustelin, L, Pietiläinen, KH, Rissanen, A, Sovijärvi, A, Piirilä, P, Naukkarinen, J, Peltonen, L, Kaprio, J, Yki-Järvinen, H 2008, 'Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity', American Journal of Physiology: Endocrinology and Metabolism, vol 295, no. 1, pp. E148-E154.

Myllärniemi, M, Vuorinen, K, Pulkkinen, V, Kankaanranta, H, Aine, T, Salmenkivi, KM, Keski-Oja, J, Koli, K, Kinnula, V 2008, 'Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype', Journal of Pathology, vol 214, no. 4, pp. 456-463.

Nousiainen, HO, Kestilä, M, Pakkasjärvi, N, Honkala, H, Kuure, S, Tallila, J, Vuopala, K, Ignatius, J, Herva, R, Peltonen, L 2008, 'Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease', Nature Genetics, vol 40, no. 2, pp. 155-157.

Nyholt, DR, LaForge, KS, Kallela, M, Alakurtti, K, Anttila, V, Farkkila, M, Hamalainen, E, Kaprio, J, Kaunisto, MA, Heath, AC, Montgomery, GW, Goebel, H, Todt, U, Ferrari, MD, Launer, LJ, Frants, RR, Terwindt, GM, de Vries, B, Verschuren, WMM, Brand, J, Freilinger, T, Pfaffenrath, V, Straube, A, Ballinger, DG, Zhan, Y, Daly, MJ, Cox, DR, Dichgans, M, van den Maagdenberg, AMJM, Kubisch, C, Martin, NG, Wessman, M, Peltonen, L, Palotie, A 2008, 'A high-density association screen of 155 ion transport genes for involvement with common migraine', Human Molecular Genetics, vol 17, no. 21, pp. 3318-3331.

Orho-Melander, M, Melander, O, Guiducci, C, Tuomi, T, Peltonen, L, Groop, L, Taskinen, M 2008, 'Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations', Diabetes, vol 57, no. 11, pp. 3112-3121.

Orsmark-Pietras, C, Melen, E, Vendelin, J, Bruce, S, Laitinen, A, Laitinen, LA, Lauener, R, Riedler, J, von Mutius, E, Doekes, G, Wickman, M, van Hage, M, Pershagen, G, Scheynius, A, Nyberg, F, Kere, J, PARSIFAL Genet Study Grp 2008, 'Biological and genetic interaction between Tenascin C and Neuropeptide S receptor 1 in allergic diseases', Human Molecular Genetics, vol 17, no. 11, pp. 1673-1682.

Ortega-Alonso, A, Sipilae, S, Kujala, UM, Kaprio, J, Rantanen, T 2008, 'Body fat and mobility are explained by common genetic and environmental influences in older women', Obesity, vol 16, no. 7, pp. 1616-1621.

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Oswell, G, Kaunisto, M, Kallela, M, Hämäläinen, E, Anttila, V, Kaprio, J, Färkkilä, M, Wessman, M, Palotie, A 2008, 'No association of migraine to the GABA-A receptor complex on chromosome 15', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 147B, no. 1, pp. 33-36.

Pajala, S, Era, P, Koskenvuo, M, Kaprio, J, Törmäkangas, T, Rantanen, T 2008, 'Force platform balance measures as predictors of indoor and outdoor falls in community-dwelling women aged 63-76 years', Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, vol 63A, no. 2, pp. 171-178.

Palmer, C, Mallery, E, Turunen, JA, Hsieh, H, Peltonen, L(, Lönnqvist, J, Woodward, A, Sinsheimer, J, Peltonen, L 2008, 'Effect of Rhesus D incompatibility on schizophrenia depends on offspring sex', Schizophrenia Research, vol 104, no. 1-3, pp. 135-145.

Paukku, K, Kalkkinen, N, Silvennoinen, O, Kontula, K, Lehtonen, JYA 2008, 'p100 increases AT1R expression through interaction with AT1R 3'-UTR', Nucleic Acids Research, vol 36, no. 13, pp. 4474-4487.

Pegelow, M, Peyrard-Janvid, M, Zucchelli, M, Fransson, I, Larson, O, Kere, J, Larsson, C, Karsten, A 2008, 'Familial non-syndromic cleft lip and palate - analysis of the IRF6 gene and clinical phenotypes', European Journal of Orthodontics, vol 2008, no. 30, pp. 169-175.

Pelkonen, M, Marttunen, M, Kaprio, J, Huurre, T, Aro, H 2008, 'Adolescent risk factors for episodic and persistent depression in adulthood. A 16-year prospective follow-up study of adolescents', Journal of Affective Disorders, vol 106, no. 1-2, pp. 123-131.

Pergadia, ML, Glowinski, AL, Agrawal, A, Montgomery, GW, Loukola, A, Broms, UH, Saccone, SF, Korhonen, T, Wang, JC, Grant, JD, Lessov-Schalggar, CN, Todorov, AA, Wray, NR, Heikkila, K, Statham, DJ, Henders, A, Campbell, M, Rice, JP, Todd, RD, Goate, AM, Peltonen, L, Heath, AC, Kaprio, J, Martin, NG, Madden, PAF 2008, 'Genetic Linkage and Association Findings for DSM-IV Major Depressive Disorder: Is the Metabotropic Glutamate Receptor 7 Gene (GRM7) an Important Risk Factor for Depression in Smokers?', Behavior Genetics, vol 38, pp. 643-643.

Pietilainen, KH, Korkeila, M, Yki-Jarvinen, H, Kaprio, J, Rissanen, A 2008, 'Eating behavior in obesity - A study in monozygotic and dizygotic twins', International Journal of Obesity, vol 32, pp. S203-S203.

Pietiläinen, KH, Kaprio, J, Borg, P, Plasqui, G, Yki-Järvinen, H, Kujala, UM, Rose, RJ, Westerterp, KR, Rissanen, A 2008, 'Physical inactivity and obesity: a vicious circle', Obesity, vol 16, no. 2, pp. 409-414.

Pietiläinen, KH, Naukkarinen, J, Rissanen, A, Saharinen, JMN, Ellonen, P, Keränen, H, Suomalainen Wartiovaara, A, Götz, A, Suortti, T, Yki-Järvinen, H, Oresic, M, Kaprio, J, Palotie, L 2008, 'Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity', PLoS Medicine, vol 5, no. 3, pp. e51.

Pietiläinen, KH, Gatu, C, Naukkarinen, J, Sysi-Aho, M, Seppanen-Laakso, T, Gopalacharyulu, P, Mattila, I, Yki-Järvinen, H, Peltonen, L, Kaprio, J, Rissanen, A, Oresic, M 2008, 'Global Metabolomics Profiles of Adipose Tissue, Serum and Urine in Weight-Discordant Monozygotic Twin Pairs', Obesity, vol 16, pp. S60-S60.

Pöntynen, N, Strengell, M, Sillanpää, N, Saharinen, J, Ulmanen, I, Julkunen, I, Peltonen, L 2008, 'Critical immunological pathways are downregulated in APECED patient dendritic cells', Journal of Molecular Medicine, vol 86, no. 10, pp. 1139-1152.

Raevuori, A, Kaprio, J, Hoek, HW, Sihvola, E, Rissanen, A, Keski-Rahkonen, A 2008, 'Anorexia and Bulimia Nervosa in Same-Sex and Opposite-Sex Twins: Lack of Association With Twin Type in a Nationwide Study of Finnish Twins', American Journal of Psychiatry, vol 165, no. 12, pp. 1604-1610.

Raevuori, A, Keski-Rahkonen, A, Hoek, HW, Sihvola, E, Rissanen, A, Kaprio, J 2008, 'Lifetime anorexia nervosa in young men in the community: Five cases and their co-twins', International Journal of Eating Disorders, vol 41, no. 5, pp. 458-463.

Rehnströ, K, Ylisaukko-oja, T, Vanhala, R, Vendt, LV, Peltonen, L, Hovatta, I, Rehnström, K, Wendt, LV 2008, 'No association between common variants in glyoxalase 1 and autism spectrum disorders', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 147B, no. 1, pp. 124-127.

Ripatti, S, Makela, P 2008, 'Conditional models accounting for regression to the mean in observational multi-wave panel studies on alcohol consumption', Addiction Biology, vol 103, pp. 24-31.

Ritvanen, E, Tervaniemi, MH, Tommiska, J, Raivio, T 2008, 'Kallmannin oireyhtymä', Duodecim, vol 124, no. 22, pp. 2547-2554.

Ronkainen, PHA, Pöllänen, E, Törmäkangas, T, Tiainen, K, Koskenvuo, M, Kaprio, J, Rantanen, T, Sipilä, S, Kovanen, V 2008, 'Catechol-O-Methyltransferase Gene Polymorphism Is Associated with Skeletal Muscle Properties in Older Women Alone and Together with Physical Activity', PLoS One, vol 3, no. 3, pp. e1819.

Ronn, T, Poulsen, P, Hansson, O, Holmkvist, J, Almgren, P, Nilsson, P, Tuomi, T, Isomaa, B, Groop, L, Vaag, A, Ling, C 2008, 'Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle', Diabetologia, vol 51, no. 7, pp. 1159-1168.

Rose, RJ, Kaprio, J 2008, 'Genes, environments, and adolescent substance use: retrospect and prospect from the FinnTwin studies', Acta Psychologica Sinica, vol 40, no. 10, pp. 1062-1072.

Saarela, J, Leppä, V, Palotie, A, Peltonen, L, International Multiple Sclerosis Genetics Consortium (IMSGC) 2008, 'Refining genetic associations in multiple sclerosis', Lancet Neurology, vol 7, no. 7, pp. 567-569.

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Salmela, E, Lappalainen, T, Fransson, I, Andersen, PM, Dahlman-Wright, K, Fiebig, A, Sistonen, P, Savontaus, M, Schreiber, S, Kere, J, Lahermo, P 2008, 'Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe', PLoS One, vol 3, pp. -.

Schantz, CV, Saharinen, J, Kopra, O, Cooper, JD, Gentile, M, Hovatta, I, Peltonen, L, Jalanko, A 2008, 'Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases', BMC Genomics, vol 9, no. 146, pp. 1-14.

Sihvola, E, Rose, RJ, Dick, DM, Pulkkinen, L, Marttunen, M, Kaprio, J 2008, 'Early-onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescent Finnish twins', Addiction, vol 103, no. 12, pp. 2045-2053.

Silander, K, Alanne, M, Kristiansson, K, Saarela, O, Ripatti, S, Auro, K, Karvanen, J, Kulathinal, S, Niemela, M, Ellonen, P, Vartiainen, E, Jousilahti, P, Saarela, J, Kuulasmaa, K, Evans, A, Perola, M, Salomaa, V, Peltonen, L 2008, 'Gender differences in genetic risk profiles for cardiovascular disease', PLoS One, vol 3, no. 10, pp. e3615.

Siljander, T, Karppelin, M, Vähäkuopus, S, Syrjänen, J, Toropainen, M, Kere, J, Vuento, R, Jussila, T, Vuopio-Varkkila, J 2008, 'Acute bacterial, nonnecrotizing cellulitis in Finland: microbiological findings', Clinical Infectious Diseases, vol 46, no. 6, pp. 855-861.

Silventoinen, K, Magnusson, PKE, Tynelius, P, Kaprio, J, Rasmussen, F 2008, 'Heritability of body size and muscle strength in young adulthood: A study of one million Swedish men', Genetic Epidemiology, vol 32, no. 4, pp. 341-349.

Silventoinen, K, Pietiläinen, KH, Tynelius, P, Sorensen, TIA, Kaprio, J, Rasmussen, F 2008, 'Genetic regulation of growth from birth to 18 years of age: The Swedish young male twins study', American Journal of Human Biology, vol 20, no. 3, pp. 292-298.

Silventoinen, K, Hammar, N, Hedlund, E, Koskenvuo, M, Ronnemaa, T, Kaprio, J 2008, 'Selective international migration by social position, health behaviour and personality', European Journal of Public Health, vol 18, no. 2, pp. 150-155.

Soronen, P, Silander, K, Antila, M, Palo, O, Tuulio-Henriksson, A, Kieseppä, T, Ellonen, P, Wedenoja, J, Turunen, J, Pietiläinen, O, Hennah, W, Lönnqvist, J, Peltonen, L, Partonen, T, Paunio, T, Turunen, JA 2008, 'Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample', Biological Psychiatry, vol 64, no. 5, pp. 438-442.

Sovijaervi, O, Kaprio, J, Rissanen, A, Yki-Jaervinen, H, Pietilaeinen, K 2008, 'Obesity affects the regional distribution of bone density and mass - a monozygotic twin pair study', International Journal of Obesity, vol 32, pp. S45-S45.

Stefansson, H, Rujescu, D, Cichon, S, Pietilainen, OPH, Ingason, A, Steinberg, S, Fossdal, R, Sigurdsson, E, Sigmundsson, T, Buizer-Voskamp, JE, Hansen, T, Jakobsen, KD, Muglia, P, Francks, C, Matthews, PM, Gylfason, A, Halldorsson, BV, Gudbjartsson, D, Thorgeirsson, TE, Sigurdsson, A, Jonasdottir, A, Jonasdottir, A, Bjornsson, A, Mattiasdottir, S, Blondal, T, Haraldsson, M, Magnusdottir, BB, Giegling, I, Moeller, H, Hartmann, A, Shianna, KV, Ge, D, Need, AC, Crombie, C, Fraser, G, Walker, N, Lonnqvist, J, Suvisaari, J, Tuulio-Henriksson, A, Paunio, T, Toulopoulou, T, Bramon, E, Di Forti, M, Murray, R, Ruggeri, M, Vassos, E, Tosato, S, Walshe, M, Li, T, Vasilescu, C, Muehleisen, TW, Wang, AG, Ullum, H, Djurovic, S, Melle, I, Olesen, J, Kiemeney, LA, Franke, B, Sabatti, C, Freimer, NB, Gulcher, JR, Thorsteinsdottir, U, Kong, A, Andreassen, OA, Ophoff, RA, Georgi, A, Rietschel, M, Werge, T, Petursson, H, Goldstein, DB, Noethen, MM, Peltonen, L, Collier, DA, St Clair, D, Stefansson, K, GROUP 2008, 'Large recurrent microdeletions associated with schizophrenia', Nature, vol 455, pp. 232-61.

Stenman, SM, Lindfors, K, Korponay-Szabo, IR, Lohi, O, Saavalainen, P, Partanen, J, Haimila, K, Wieser, H, Mäki, M, Kaukinen, K 2008, 'Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits', BMC Immunology, vol 9, no. 6, [8, pp. ].

Suonsyrjä, T, Hannila-Handelberg, T, Paavonen, KJ, Miettinen, HE, Donner, K, Strandberg, T, Tikkanen, I, Tilvis, R, Pentikäinen, PJ, Kontula, K, Hiltunen, TP 2008, 'Laboratory tests as predictors of the antihypertensive effects of amlodipine, bisoprolol, hydrochlorothiazide and losartan in men: results from the randomized, double-blind, crossover GENRES study', Journal of Hypertension, vol 26, pp. 1250-1256.

Sverrild, A, Backer, V, Kyvik, KO, Kaprio, J, Milman, N, Svendsen, CB, Thomsen, SF 2008, 'Heredity in sarcoidosis: a registry-based twin study', Thorax, vol 63, no. 10, pp. 894-896.

Tallila, J, Jakkula, E, Peltonen, L, Salonen, R, Kestilä, M 2008, 'Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzle', American Journal of Human Genetics, vol 82, no. 6, pp. 1361-1367.

Tapia-Paez, I, Tamminen, K, Massinen, S, Roy, AL, Kere, J 2008, 'The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia', FASEB Journal, vol 22, no. 8, pp. 3001-3009.

Tiainen, KM, Perola, M, Kovanen, VM, Sipilä, S, Tuononen, KA, Rikalainen, K, Kauppinen, MA, Widen, EIM, Kaprio, J, Rantanen, T, Kujala, UM 2008, 'Genetics of maximal walking speed and skeletal muscle characteristics in older women', Twin Research and Human Genetics, vol 11, no. 3, pp. 321-334.

Tiainen, K, Perola, M, Kovanen, V, Sipilä, S, Rikalainen, K, Widen, EIM, Kaprio, J, Rantanen, T, Kujala, T 2008, 'Genome-wide linkage analysis for maximal walking speed and skeletal muscle characteristics in older women', Twin Research and Human Genetics, vol 2008/11, pp. 321-324.

Tiala, I, Wakkinen, J, Suomela, S, Puolakkainen, P, Tammi, R, Forsberg, S, Rollman, O, Kainu, K, Rozell, B, Kere, J, Saariaho-Kere, U, Elomaa, O, Saarialho-Kere, U 2008, 'The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice', Human Molecular Genetics, vol 17, no. 7, pp. 1043-1051.

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Tiira, KA, Vilhunen, S, Hirvonen, H, Laurila, A 2008, 'The bold and the variable: fish with high heterozygosity act recklessly in the vicinity of predators', Ethology, vol 114, no. 1, pp. 7-15.

Tolonen, N, Forsblom, C, Thorn, L, Waden, J, Rosengård-Bärlund, M, Saraheimo, M, Heikkilä, O, Pettersson-Fernholm, K, Taskinen, M, Groop, P 2008, 'Relationship between lipid profiles and kidney function in patients with type 1 diabetes', Diabetologia, vol 51, pp. 12-20.

Tyybäkinoja, A, Elonen, E, Vauhkonen, H, Saarela, J, Knuutila, S 2008, 'Single nucleotide polymorphism microarray analysis of karyotypically normal acute myeloid leukemia reveals frequent copy number neutral loss of heterozygosity: letters to the editor', Haematologica, vol 93, no. 4, pp. 631-632.

Valli-Jaakola, KM, Suviolahti, E, Schalin-Jäntti, C, Ripatti, SO, Silander, K, Oksanen, L, Salomaa, V, Peltonen, L, Kontula, K 2008, 'Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns', Obesity, vol 16, no. 9, pp. 2113-2119.

Van Erp, TGM, Kieseppa, T, Bearden, CE, Sun, D, Zimmerman, LL, Tran, HL, Correll, C, Wobbekind, A, Haukka, J, Partonen, T, Huttunen, MO, Kaprio, J, Loennqvist, J, Poutanen, V, Toga, AW, Thompson, PM, Cannon, TD 2008, 'Cortical gray matter density in twins discordant for bipolar I disorder', Biological Psychiatry, vol 63, pp. 26S-27S.

Videman, T, Battie, MC, Parent, E, Gibbons, LE, Vainio, P, Kaprio, J 2008, 'Progression and determinants of quantitative magnetic resonance imaging measures of lumbar disc degeneration - A five-year follow-up of adult male monozygotic twins', Spine, vol 33, no. 13, pp. 1484-1490.

Viitasalo, M, Oikarinen, L, Väänänen, H, Kontula, K, Toivonen, L, Swan, H 2008, 'U-waves and T-wave peak to T-wave end intervals in patients with catecholaminergic polymorphic ventricular tachycardia, effects of beta-blockers', Heart rhythm., vol 5, pp. 1382-1388.

Viljanen, A, Kaprio, J, Pyykko, I, Sorri, M, Koskenvuo, M, Rantanen, T 2008, 'HEARING AS A PREDICTOR OF WALKING DIFFICULTIES IN OLDER WOMEN', Gerontologist, vol 48, pp. 100-100.

Virta, JJ, Karrasch, M, Kaprio, J, Koskenvuo, M, Räihä, I, Viljanen, T, Rinne, JO 2008, 'Cerebral glucose metabolism in dizygotic twin pairs discordant for Alzheimer's disease', Dementia and Geriatric Cognitive Disorders, vol 25, no. 1, pp. 9-16.

Virtanen, P, Vahtera, J, Broms, U, Sillanmäki, LH, Kivimaeki, M, Koskenvuo, M 2008, 'Employment trajectory as determinant of change in health-related lifestyle: the prospective HeSSup study', European Journal of Public Health, vol 18, no. 5, pp. 504-508.

Vivatbutsiri, P, Ichinose, S, Hytönen, M, Sainio, K, Eto, K, Iseki, S 2008, 'Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant', Journal of Anatomy, vol 212, pp. 603-611.

Vuoksimaa, E, Kaprio, J, Pulkkinen, L, Rose, RJ 2008, 'Evidence of prenatal transfer of testosterone in humans?: Decreased left-handedness in females from opposite-sex twin pairs', International journal of psychology research., vol 43, pp. 522-522.

Vuoksimaa, E, Tuulio-Henriksson, A, Hokkanen, L, Kaprio, J, Rose, RJ 2008, 'Extreme Male/Female Brain Defined with Two Neuropsychological Tests', Behavior Genetics, vol 38, pp. 652-652.

Waller, K, Kaprio, J, Kujala, UM 2008, 'Associations between long-term physical activity, waist circumference and weight gain: a 30-year longitudinal twin study', International Journal of Obesity, vol 32, no. 2, pp. 353-361.

Wedenoja, S, Örmälä, T, Berg, U, Edström Halling, S, Jalanko, H, Karikoski, R, Kere, J, Holmberg, C, Höglund, P, Wedenoja, SKJ 2008, 'The impact of sodium chloride and volume depletion in the chronic kidney disease of congenital chloride diarrhea', Kidney International, vol 74, no. 8, pp. 1085-1093.

Wedenoja, S, Holmberg, C, Höglund, P 2008, 'Oryl butyrate in treatment of congenital chloride diarrhea', American Journal of Gastroenterology, vol 103, no. 1, pp. 252-254.

Wedenoja, J, Loukola, A, Tuulio-Henriksson, A, Paunio, T, Ekelund, J, Silander, K, Varilo, T, Heikkilä, K, Suvisaari, J, Partonen, T, Lönnqvist, J, Peltonen, L 2008, 'Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families', Molecular Psychiatry, vol 13, no. 7, pp. 673-684.

Wehkalampi, K, Widen, E, Laine, T, Palotie, A, Dunkel, L 2008, 'A locus on chromosome 2 regulates the timing of puberty', Frontiers of Hormone Research, vol 70, pp. 35-35.

Wehkalampi, K, Widen, EIM, Laine, T, Palotie, A, Dunkel, L 2008, 'Patterns of inheritance of constitutional delay of growth and puberty in families of adolescent girls and boys referred to specialist pediatric care', Journal of Clinical Endocrinology and Metabolism, vol 93, no. 3, pp. 723-728.

Wehkalampi, K, Silventoinen, K, Kaprio, J, Dick, DM, Rose, RJ, Pulkkinen, L, Dunkel, L 2008, 'Genetic and environmental influences on pubertal timing assessed by height growth', American Journal of Human Biology, vol 20, no. 4, pp. 417-423.

Wehkalampi, K, Widen, E, Laine, T, Palotie, A, Dunkel, L 2008, 'Association of the timing of puberty with a chromosome 2 locus', Journal of Clinical Endocrinology and Metabolism, vol 93, pp. 4833-4839.

Yasuda, K, Miyake, K, Horikawa, Y, Tuomi, T, Groop, L 2008, 'Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus', Nature Genetics, vol 40, no. 9, pp. 1092-1097.

Yokoyama, Y, Sugimoto, M, Silventoinen, K, Kaprio, J 2008, 'Weight growth charts from birth to 6 years of age in Japanese triplets', Twin Research and Human Genetics, vol 11, no. 6, pp. 641-647.

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Yu, X, Koczan, D, Sulonen, AK, Akkad, DA, Kroner, A, Comabella, M, Costa, G, Corongiu, D, Goertsches, R, Camina-Tato, M, Thiesen, H, Nyland, HI, Mork, SJ, Montalban, X, Rieckmann, P, Marrosu, MG, Myhr, K, Epplen, JT, Saarela, J, Ibrahim, SM 2008, 'mtDNA nt13708A Variant Increases the Risk of Multiple Sclerosis', PLoS One, vol 3, pp. -.

Zeggini, E, Scott, LJ, Saxena, R, Voight, BF, Marchini, JL, Hu, T, de Bakker, PIW, Abecasis, GR, Almgren, P, Andersen, G, Ardlie, K, Bostroem, KB, Bergman, RN, Bonnycastle, LL, Borch-Johnsen, K, Burtt, NP, Chen, H, Chines, PS, Daly, MJ, Deodhar, P, Ding, C, Doney, ASF, Duren, WL, Elliott, KS, Erdos, MR, Frayling, TM, Freathy, RM, Gianniny, L, Grallert, H, Grarup, N, Groves, CJ, Guiducci, C, Hansen, T, Herder, C, Hitman, GA, Hughes, TE, Isomaa, B, Jackson, AU, Jorgensen, T, Kong, A, Kubalanza, K, Kuruvilla, FG, Kuusisto, J, Langenberg, C, Lango, H, Lauritzen, T, Li, Y, Lindgren, CM, Lyssenko, V, Marvelle, AF, Meisinger, C, Midthjell, K, Mohlke, KL, Morken, MA, Morris, AD, Narisu, N, Nilsson, P, Owen, KR, Palmer, CNA, Payne, F, Perry, JRB, Pettersen, E, Platou, C, Prokopenko, I, Qi, L, Qin, L, Rayner, NW, Rees, M, Roix, JJ, Sandbaek, A, Shields, B, Sjogren, M, Steinthorsdottir, V, Stringham, HM, Swift, AJ, Thorleifsson, G, Thorsteinsdottir, U, Timpson, NJ, Tuomi, T, Tuomilehto, J, Walker, M, Watanabe, RM, Weedon, MN, Willer, CJ, Illig, T, Hveem, K, Hu, FB, Laakso, M, Stefansson, K, Pedersen, O, Wareham, NJ, Barroso, I, Hattersley, AT, Collins, FS, Groop, L, McCarthy, MI, Boehnke, M, Altshuler, D, Wellcome Trust Case Control Consor, DIAGRAM Consortium 2008, 'Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes', Nature Genetics, vol 40, no. 5, pp. 638-645.

Zhang, P, Dixon, M, Zucchelli, M, Hambiliki, F, Levkov, L, Hovatta, O, Kere, J 2008, 'Expression Analysis of the NLRP Gene Family Suggests a Role in Human Preimplantation Development', PLoS One, vol 2008, no. 3, pp. -.

van Erp, TGM, Therman, S, Pirkola, T, Tuulio-Henriksson, A, Glahn, DC, Bachman, P, Huttunen, MO, Lönnqvist, J, Hietanen, M, Kaprio, J, Koskenvuo, M, Cannon, TD 2008, 'Verbal recall and recognition in twins discordant for schizophrenia', Psychiatry Research, vol 159, no. 3, pp. 271-280.

von Schantz, C, Saharinen, J, Kopra, O, Cooper, JD, Gentile, M, Hovatta, I, Palotie, L, Jalanko, A 2008, 'Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases.', BMC Genomics, vol 2008/28.

2009 Abdul-Ghani, MA, Lyssenko, V, Tuomi, T, DeFronzo, RA, Groop, L 2009, 'Fasting Versus Postload Plasma Glucose Concentration and the Risk for Future Type 2 Diabetes Results from the Botnia Study', Diabetes Care, vol 32, pp. 281-286.

Anisimov, A, Alitalo, A, Korpisalo, P, Soronen, J, Kaijalainen, S, Leppanen, V, Jeltsch, M, Yla-Herttuala, S, Alitalo, K 2009, 'Activated Forms of VEGF-C and VEGF-D Provide Improved Vascular Function in Skeletal Muscle', Circulation Research, vol 104, pp. 1302-U156.

Artto, V, Anttila, V, Rantanen, K, Kallela, M, Färkkilä, M 2009, 'Valsalva maneuver as migraine inducer: a case report of a woman with patent foramen ovale and an ischemic stroke', Headache, vol 49, no. 1, pp. 146-147.

Aulchenko, YS, Ripatti, S, Lindqvist, I, Boomsma, D, Heid, IM, Pramstaller, PP, Penninx, BWJH, Janssens, ACJW, Wilson, JF, Spector, T, Martin, NG, Pedersen, NL, Kyvik, KO, Kaprio, J, Hofman, A, Freimer, NB, Järvelin, M, Gyllensten, U, Campbell, H, Rudan, I, Johansson, Å, Marroni, F, Hayward, C, Vitart, V, Jonasson, I, Pattaro, C, Wright, A, Hastie, N, Pichler, I, Hicks, AA, Falchi, M, Willemsen, G, Hottenga, J, de Geus, EJC, Montgomery, GW, Whitfield, J, Magnusson, P, Saharinen, J, Perola, M, Silander, K, Isaacs, A, Sijbrands, EJG, Uitterlinden, AG, Witteman, JCM, Oostra, BA, Elliott, P, Ruokonen, A, Sabatti, C, Gieger, C, Meitinger, T, Kronenberg, F, Döring, A, Wichmann, H, Smit, JH, McCarthy, MI, van Duijn, CM, Peltonen, L, ENGAGE Consortium 2009, 'Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts', Nature Genetics, vol 41, no. 1, pp. 47-55.

Bachman, P, Kim, J, Yee, CM, Therman, S, Manninen, M, Lönnqvist, J, Kaprio, J, Huttunen, M, Näätänen, R, Cannon, TD 2009, 'Efficiency of working memory encoding in twins discordant for schizophrenia', Psychiatry Research: Neuroimaging, vol 174, no. 2, pp. 97-104.

Backlund, M, Paukku, K, Daviet, L, de Boer, RA, Valo, EA, Hautaniemi, S, Kalkkinen, N, Ehsan, A, Kontula, K, Lehtonen, JYA 2009, 'Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase', Nucleic Acids Research, vol 37, no. 7, pp. 2346-2358.

Battie, MC, Videman, T, Kaprio, J, Gibbons, LE, Gill, K, Manninen, H, Saarela, J, Peltonen, L 2009, 'The Twin Spine Study: Contributions to a changing view of disc degeneration', The spine journal : official journal of the North American Spine Society, vol 9, no. 1, pp. 47-59.

Benyamin, B, McRae, AF, Zhu, G, Gordon, S, Henders, AK, Palotie, A, Peltonen, L, Martin, NG, Montgomery, GW, Whitfield, JB, Visscher, PM 2009, 'Variants in TF and HFE explain ~40% of genetic variation in serum-transferrin levels', American Journal of Human Genetics, vol 84, no. 1, pp. 60-65.

Bogl, LH, Pietilainen, KH, Rissanen, A, Kaprio, J 2009, 'Improving the Accuracy of Self-Reports on Diet and Physical Exercise: The Co-Twin Control Method', Twin Research and Human Genetics, vol 12, pp. 531-540.

Bonetti, A, Koivisto, K, Pirttila, T, Elovaara, I, Reunanen, M, Laaksonen, M, Ruutiainen, J, Peltonen, L, Rantamäki-Häkkinen, T, Tienari, PJ 2009, 'A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility', Journal of Neuroimmunology, vol 208, no. 1-2, pp. 119-124.

Brandes, JL, Poole, AC, Kallela, M, Schreiber, CP, MacGregor, EA, Silberstein, SD, Tobin, J, Shaw, R 2009, 'Short-term frovatriptan for the prevention of difficult-to-treat menstrual migraine attacs', Cephalalgia, vol 29, pp. 1133-1148.

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Bruce, S, Hannula-Jouppi, K, Peltonen, J, Kere, J, Lipsanen-Nyman, M 2009, 'Clinically distinct epigenetic subgroups in Silver-Russell syndrome: the degree of H19 hypomethylation associates with phenotype severity and genital and skeletal anomalies', Journal of Clinical Endocrinology and Metabolism, vol 94, no. 2, pp. 579-587.

Bruce, S, Nyberg, F, Melen, E, James, A, Pulkkinen, VP, Orsmark-Pietras, C, Bergström, A, Dahlen, B, Wickman, M, Von Mutius, E, Doekes, G, Lauener, R, Riedler, J, Eder, W, Van Hage, M, Pershagen, G, Scheynius, A, Kere, J 2009, 'The protective effect of farm animal exposure on childhood allergy is modified by NPSR1 polymorphisms', Journal of Medical Genetics, vol 46, no. 3, pp. 159-167.

Bunck, MC, Diamant, M, Cornér, A, Eliasson, B, Malloy, JL, Shaginian, RM, Deng, W, Kendall, DM, Taskinen, M, Smith, U, Yki-Järvinen, H, Heine, RJ 2009, 'One-Year Treatment With Exenatide Improves -Cell Function, Compared With Insulin Glargine, in Metformin-Treated Type 2 Diabetic Patients', Diabetes Care, vol 32, pp. 762-768.

Bäckmand, HM, Kaprio, J, Kujala, UM, Sarna, S 2009, 'Physical activity, mood and the functioning of daily living - A longitudinal study among former elite athletes and referents in middle and old age', Archives of Gerontology and Geriatrics, vol 48, no. 1, pp. 1-9.

Cefalú, AB, Noto, D, Arpi, ML, Yin, F, Spina, R, Hilden, H, Barbagallo, CM, Carroccio, A, Tarugi, P, Squatrito, S, Vigneri, R, Taskinen, M, Peterfy, M, Averna, MR 2009, 'Novel LMF1 Nonsense Mutation in a Patient with Severe Hypertriglyceridemia', Journal of Clinical Endocrinology and Metabolism, vol 94, pp. 4584-4590.

Chasman, DI, Pare, G, Mora, S, Hopewell, JC, Peloso, G, Clarke, R, Cupples, LA, Hamsten, A, Kathiresan, S, Maelarstig, A, Ordovas, JM, Ripatti, S, Parker, AN, Miletich, JP, Ridker, PM 2009, 'Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis', PLoS Genetics, vol 5, no. 11, pp. e1000730.

Creemers, HE, Korhonen, T, Kaprio, J, Vollebergh, WAM, Ormel, J, Verhulst, FC, Huizink, AC 2009, 'The role of temperament in the relationship between early onset of tobacco and cannabis use: The TRAILS study', Drug and Alcohol Dependence, vol 104, no. 1-2, pp. 113-118.

Dahdouh, F, Anthoni, H, Tapia-Paez, I, Peyrard-Janvid, M, Schulte-Korne, G, Warnke, A, Remschmidt, H, Ziegler, A, Kere, J, Muller-Myhsok, B, Nöthen, MM, Schumacher, J, Zucchelli, M 2009, 'Further evidence for DYX1C1 as a susceptibility factor for dyslexia', Psychiatric Genetics, vol 19, no. 2, pp. 59-63.

De Jager, PL, Baecher-Allan, C, Maier, LM, Arthur, AT, Ottoboni, L, Barcellos, L, McCauley, JL, Sawcer, S, Goris, A, Saarela, J, Yelensky, R, Price, A, Leppa, V, Patterson, N, de Bakker, PIW, Tran, D, Aubin, C, Pobywajlo, S, Rossin, E, Hu, X, Ashley, CW, Choy, E, Rioux, JD, Pericak-Vance, MA, Ivinson, A, Booth, DR, Stewart, GJ, Palotie, A, Peltonen, L, Dubois, B, Haines, JL, Weiner, HL, Compston, A, Hauser, SL, Daly, MJ, Reich, D, Oksenberg, JR, Hafler, DA 2009, 'The role of the CD58 locus in multiple sclerosis', Proceedings of the National Academy of Sciences of the United States of America, vol 106, no. 13, pp. 5264-5269.

Di Marzo, V, Verrijken, A, Hakkarainen, A, Petrosino, S, Mertens, I, Lundbom, N, Piscitelli, F, Westerbacka, JJ, Soro-Paavonen, A, Matias, I, Van Gaal, L, Taskinen, M 2009, 'Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects', European Journal of Endocrinology, vol 161, no. 5, pp. 715-722.

Dick, DM, Bernard, M, Aliev, F, Viken, R, Pulkkinen, L, Kaprio, J, Rose, RJ 2009, 'The role of socioregional factors in moderating genetic influences on early adolescent behavior problems and alcohol use', Alcoholism: Clinical and Experimental Research, vol 33, no. 10, pp. 1739-1748.

Donner, K, Hiltunen, TP, Suonsyrjä, T, Hannila-Handelberg, T, Tikkanen, I, Antikainen, M, Hirvonen, A, Kontula, K 2009, 'CYP2C9 genotype modifies activity of the renin-angiotensin-aldosterone system in hypertensive men', Journal of Hypertension, vol 27, pp. 2001-2009.

Einarsdottir, E, Koskinen, L, Dukes, E, Kainu, K, Suomela, S, Lappalainen, M, Ziberna, F, Korponay-Szabo, IR, Kurppa, K, Kaukinen, K, Adany, R, Pocsai, Z, Szeles, G, Färkkilä, M, Turunen, U, Halme, L, Paavola-Sakki, P, Not, T, Vatta, S, Ventura, A, Löfberg, R, Torkvist, L, Bresso, F, Halfvarson, J, Mäki, M, Kontula, K, Saarialho-Kere, U, Kere, J, D'Amato, M, Saavalainen, P 2009, 'IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease', BMC Medical Genetics, vol 10, no. 8, [10, pp. ].

Einarsdottir, E, Koskinen, LLE, Korponay-Szabo, IR, Kurppa, K, Kaukinen, K, Sistonen, P, Pocsai, Z, Széles, G, Ádány, R, Maki, M, Kere, J, Saavalainen, P 2009, 'Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations', Tissue Antigens, vol 74, no. 5, pp. 408-416.

Ekelund, E, Bradley, M, Weidinger, S, Jovanovic, DL, Johansson, C, Lindgren, CM, Todorova, A, Jakob, T, Illig, T, von Mutius, E, Braun-Fahrlaender, C, Doekes, G, Riedler, J, Schehynius, A, Pershagen, G, Kockum, I, Kere, J 2009, 'Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations', Acta Dermato-Venereologica, vol 89, no. 2, pp. 115-121.

Elomaa, O, Skoog, T, Pasonen-Seppänen, SM, Forsberg, S, Ahokas, K, Jeskanen, L, Pärssinen, J, Tiala, I, Rollman, O, Lohi, J, Saarialho-Kere, U 2009, 'Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells', Journal of Investigative Dermatology, vol 129, no. 1, pp. 119-130.

Finni, T, Kovanen, V, Ronkainen, PHA, Pöllanen, E, Bashford, GR, Kaprio, J, Alen, M, Kujala, UM, Sipilä, S 2009, 'Combination of hormone replacement therapy and high physical activity is associated with differences in Achilles tendon size in monozygotic female twin pairs', Journal of Applied Physiology, vol 106, no. 4, pp. 1332-1337.

Forabosco, P, Neuhausen, SL, Greco, L, Naluai, ÅT, Wijmenga, C, Saavalainen, P, Houlston, RS, Ciclitira, PJ, Babron, M, Lewis, CM 2009, 'Meta-analysis of genome-wide linkage studies in celiac disease', Human Heredity, vol 68, no. 4, pp. 223-230.

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Haimila, K, Einarsdottir, E, de Kauwe, A, Koskinen, L, Pan-Hammarström, Q, Kaartinen, T, Kurppa, K, Ziberna, F, Not, T, Vatta, S, Ventura, A, Korponay-Szabo, I, Ádány, R, Pocsai, Z, Széles, G, Dukes, E, Kaukinen, K, Mäki, M, Koskinen, S, Partanen, J, Hammarström, L, Saavalainen, PM 2009, 'The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency', Genes and Immunity, vol 10, no. 2, pp. 151-161.

Hammar, N, Hakala, P, Jorgensen, L, Becker, W, Hedlund, E, Ronnemaa, T, Koskenvuo, M, Kaprio, J 2009, 'Migration and differences in dietary habits-a cross sectional study of Finnish twins in Sweden', European Journal of Clinical Nutrition, vol 63, no. 3, pp. 312-322.

He, H, Nagy, R, Liyanarachchi, S, Jiao, H, Li, W, Suster, S, Kere, J, de la Chapelle, A 2009, 'A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24', Clinical Cancer Research, vol 2008, no. 69, pp. 625-631.

Heikkila, O, Lundbom, N, Timonen, M, Groop, P-, Heikkinen, S, Mäkimattila, S 2009, 'Hyperglycaemia is associated with changes in the regional concentrations of glucose and myo-inositol within the brain', Diabetologia, vol 52, no. 3, pp. 534-540.

Heikkinen, M, Broms, U, Pitkaniemi, J, Koskenvuo, M, Meurman, J 2009, 'Key Factors in Smoking Cessation Intervention Among 15-16-Year-Olds', Journal of Behavioral Medicine, vol 35, no. 3, pp. 93-99.

Hellquist, A, Zucchelli, M, Lindgren, CM, Saarialho-Kere, U, Järvinen, T, Koskenmies, S, Julkunen, H, Onkamo, P, Skoog, T, Panelius, J, Räisänen-Sokolowski, A, Hasan, T, Widen, E, Gunnarson, I, Svenungsson, E, Padyukov, L, Assadi, G, Berglind, L, Mäkelä, V, Kivinen, K, Wong, A, Graham, DSC, Vyse, TJ, D'Amato, M, Kere, J 2009, 'Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE)', PLoS One, vol 4, no. 12, pp. e8037.

Hellquist, A, Järvinen, T, Koskenmies, S, Zucchelli, M, Orsmark-Pietras, C, Berglind, L, Panelius, J, Hasan, T, Julkunen, H, D'Amato, M, Saarialho-Kere, U, Kere, J 2009, 'Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus', Journal of Rheumatology, vol 36, no. 8, pp. 1631-1638.

Hemilä, H, Kaprio, J 2009, 'Modification of the effect of vitamin E supplementation on the mortality of male smokers by age and dietary vitamin C', American Journal of Epidemiology, vol 169, no. 8, pp. 946-953.

Hennah, W, Porteous, D 2009, 'The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes', PLoS One, vol 4, no. 3, pp. e4906, [7 s.].

Hennah, W, Thomson, P, McQuillin, A, Bass, N, Loukola, A, Anjorin, A, Blackwood, D, Curtis, D, Deary, IJ, Harris, SE, Isometsa, ET, Lawrence, J, Lonnqvist, J, Muir, W, Palotie, A, Partonen, T, Paunio, T, Pylkko, E, Robinson, M, Soronen, P, Suominen, K, Suvisaari, J, Thirumalai, S, St Clair, D, Gurling, H, Peltonen, L, Porteous, D 2009, 'DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder', Molecular Psychiatry, vol 14, no. 9, pp. 865-873.

Hiltunen, LM, Laivuori, H, Rautanen, A, Kaaja, R, Kere, J, Krusius, T, Paunio, M, Rasi, V 2009, 'Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control study', Thrombosis Research , vol 124, no. 2, pp. 167-173.

Hintsa, T, Keltikangas-Järvinen, L, Puttonen, S, Ravaja, N, Toivonen, L, Kontula, K, Swan, H 2009, 'Depressive symptoms in the congenital long QT syndrome', Annals of Medicine, vol 41, no. 7, pp. 516-521.

Hiukka, AS, ståhlman, M, Pettersson, C, Levin, M, Adiels, M, Teneberg, S, Leinonen, ES, Mattsson Huten, L, Wiklund, O, Oresic, M, Olofsson, S, Taskinen, M, Ekroos, K, Boren, J 2009, 'ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan', Diabetes-Journal, vol 58, pp. 2018-2026.

Hukkinen, M, Kaprio, J, Broms, U, Koskenvuo, M, Korhonen, T 2009, 'Characteristics and consistency of light smoking: Long-term follow-up among Finnish adults', Nicotine & Tobacco Research, vol 11, no. 7, pp. 797-805.

Hukkinen, M, Korhonen, T, Broms, UH, Koskenvuo, M, Kaprio, J 2009, 'Long-Term Smoking Behavior Patterns Predicting Self-Reported Chronic Bronchitis', COPD: Journal of chronic obstructive pulmonary disease., vol 6, no. 4, pp. 242-249.

Hunninghake, GM, Cho, MH, Tesfaigzi, Y, Soto-Quiros, ME, Avila, L, Lasky-Su, J, Stidley, C, Melen, E, Soderhall, C, Hallberg, J, Kull, I, Kere, J, Svartengren, M, Pershagen, G, Wickman, M, Lange, C, Demeo, DL, Hersh, CP, Klanderman, BJ, Raby, BA, Sparrow, D, Shapiro, SD, Silverman, EK, Litonjua, AA, Weiss, ST, Celedon, JC 2009, 'MMP12, Lung Function, and COPD in High-Risk Populations', New England Journal of Medicine, vol 2009, no. 361, pp. 2599-2608.

Hytönen, MK, Grall, A, Hedan, B, Dreano, S, Seguin, SJ, Delattre, D, Thomas, A, Galibert, F, Paulin, L, Lohi, H, Sainio, K, Andre, C 2009, 'Ancestral T-box mutation is present in many, but not all, short-tailed dog breeds', Journal of Heredity, vol 100, no. 2, pp. 236-240.

Iatan, I, Dastani, Z, Do, R, Weissglass-Volkov, D, Ruel, I, Lee, JC, Huertas-Vazquez, A, Taskinen, M, Prat, A, Seidah, NG, Pajukanta, P, Engert, JC, Genest, J 2009, 'Genetic Variation at the Proprotein Convertase Subtilisin/Kexin Type 5 Gene Modulates High-Density Lipoprotein Cholesterol Levels', Circulation, Cardiovascular genetics.

Jagodic, M, Colacios, C, Nohra, R, Dejean, AS, Beyeen, AD, Khademi, M, Casemayou, A, Lamouroux, L, Duthoit, C, Papapietro, O, Sjoholm, L, Bernard, I, Lagrange, D, Dahlman, I, Lundmark, F, Oturai, AB, Soendergaard, HB, Kemppinen, A, Saarela, J, Tienari, PJ, Harbo, HF, Spurkland, A, Ramagopalan, SV, Sadovnick, DA, Ebers, GC, Seddighzadeh, M, Klareskog, L, Alfredsson, L, Padyukov, L, Hillert, J, Clanet, M, Edan, G, Fontaine, B, Fournie, GJ, Kockum, I, Saoudi, A, Olsson, T 2009, 'A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis', Science translational medicine, vol 1, no. 10, pp. 10ra21.

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Jartti, L, Ronnemaa, T, Raitakari, OT, Hedlund, E, Hammar, N, Lassila, R, Marniemi, J, Koskenvuo, M, Kaprio, J 2009, 'Migration at early age from a high to a lower coronary heart disease risk country lowers the risk of subclinical atherosclerosis in middle-aged men', Journal of Internal Medicine, vol 265, no. 3, pp. 345-358.

Jonsson, A, Isomaa, B, Tuomi, T, Taneera, J, Salehi, A, Nilsson, P, Groop, L, Lyssenko, V 2009, 'A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion', Diabetes, vol 58, pp. 2409-2413.

Juselius, S, Kieseppä, T, Kaprio, J, Lönnqvist, J, Tuulio-Henriksson, A 2009, 'Executive functioning in twins with bipolar I disorder and healthy co-twins', Archives of Clinical Neuropsychology, vol 24, no. 6, pp. 599-606.

Kainu, K, Kivinen, K, Zucchelli, M, Suomela, S, Kere, J, Inerot, A, Baker, BS, Powles, AV, Fry, L, Samuelsson, L, Saarialho-Kere, U 2009, 'Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families', Experimental Dermatology, vol 18, no. 2, pp. 109-115.

Kallio, SP, Jakkula, E, Purcell, S, Suvela, M, Koivisto, K, Tienari, PJ, Elovaara, I, Pirttilä, T, Reunanen, M, Bronnikov, D, Viander, M, Meri, S, Hillert, J, Lundmark, F, Harbo, HF, Lorenzen, ÅR, De Jager, PL, Daly, MJ, Hafler, DA, Palotie, A, Peltonen, L, Saarela, J 2009, 'Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS', Human Molecular Genetics, vol 18, no. 9, pp. 1670-1683.

Kallio, S, Jakkula, E, Purcell, S, Suvela, M, Koivisto, K, Tienari, P, Elovaara, I, Pirttilä, T, Reunanen, M, Bronnikov, D, Viander, M, Meri, S, Hillert, J, Lundmark, F, Harbo, H, Lorentzen, A, De Jager, P, Daly, M, Hafler, D, Palotie, A, Palotie, L, Saarela, J 2009, 'Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS', Human Molecular Genetics, vol 2009/18, no. 9, pp. 1670-83.

Kaprio, J 2009, 'Genetic epidemiology of smoking behavior and nicotine dependence', COPD: Journal of chronic obstructive pulmonary disease., vol 6, no. 4, pp. 304-306.

Kardos, R, Pozsonyi, K, Nevalainen, E, Lappalainen, P, Nyitrai, M, Hild, G 2009, 'The effects of ADF/cofilin and profilin on the conformation of the ATP-binding cleft of monomeric actin', Biophysical Journal, vol 96, no. 6, pp. 2335-2343.

Karvanen, J, Silander, K, Kee, F, Tiret, L, Salomaa, V, Kuulasmaa, K, Wiklund, P, Virtamo, J, Saarela, O, Perret, C, Perola, M, Peltonen, L, Cambien, F, Erdmann, J, Samani, NJ, Schunkert, H, Evans, A 2009, 'The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts', Genetic Epidemiology, vol 33, no. 3, pp. 237-246.

Kathiresan, S, Willer, CJ, Peloso, GM, Demissie, S, Musunuru, K, Schadt, EE, Kaplan, L, Bennett, D, Li, Y, Tanaka, T, Voight, BF, Bonnycastle, LL, Jackson, AU, Crawford, G, Surti, A, Guiducci, C, Burtt, NP, Parish, S, Clarke, R, Zelenika, D, Kubalanza, KA, Morken, MA, Scott, LJ, Stringham, HM, Galan, P, Swift, AJ, Kuusisto, J, Bergman, RN, Sundvall, J, Laakso, M, Ferrucci, L, Scheet, P, Sanna, S, Uda, M, Yang, Q, Lunetta, KL, Dupuis, J, de Bakker, PIW, O'Donnell, CJ, Chambers, JC, Kooner, JS, Hercberg, S, Meneton, P, Lakatta, EG, Scuteri, A, Schlessinger, D, Tuomilehto, J, Collins, FS, Groop, L, Altshuler, D, Collins, R, Lathrop, GM, Melander, O, Salomaa, V, Peltonen, L, Orho-Melander, M, Ordovas, JM, Boehnke, M, Abecasis, GR, Mohlke, KL, Cupples, LA 2009, 'Common variants at 30 loci contribute to polygenic dyslipidemia', Nature Genetics, vol 41, no. 1, pp. 56-65.

Kathiresan, S, Peltonen, L, Altshuler, D, Myocardial Infarction Genetics Consortium 2009, 'Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants', Nature Genetics, vol 41, no. 3, pp. 334-341.

Kaunisto, MA, Sjölind, L, Sallinen, R, Pettersson-Fernholm, K, Saraheimo, M, Fröjdö, S, Forsblom, C, Fagerudd, J, Hansen, TK, Flyvbjerg, A, Wessman, M, Groop, P, FinnDiane Study Group 2009, 'Elevated MBL concentrations are not an indication of association between the MBL2 gene and type 1 diabetes or diabetic nephropathy', Diabetes, vol 58, no. 7, pp. 1710-1714.

Kauppila, E, Vanninen, E, Kuusela, T, Kaurijoki, S, Karhunen, L, Pietiläinen, K, Rissanen, A, Kaprio, J, Tiihonen, J, Kuikka, J 2009, 'Cardiac repolarization and striatal dopamine transporter function are interrelated', Nuclear Medicine Communications, vol 30, no. 9, pp. 713-717.

Kemlink, D, Polo, O, Frauscher, B, Gschliesser, V, Hogl, B, Poewe, W, Vodicka, P, Vavrova, J, Sonka, K, Nevsimalova, S, Schormair, B, Lichtner, P, Silander, K, Peltonen, L, Gieger, C, Wichmann, HE, Zimprich, A, Roeske, D, Muller-Myhsok, B, Meitinger, T, Winkelmann, J, Peltonen, L 2009, 'Replication of restless legs syndrome loci in three European populations', Journal of Medical Genetics, vol 46, no. 5, pp. 315-318.

Kemppinen, A, Suvela, M, Tienari, PJ, Elovaara, I, Koivisto, K, Pirttilä, T, Reunanen, M, Rautakorpi, I, Hillert, J, Lundmark, F, Oturai, A, Ryder, L, Harbo, HF, Celius, EG, Palotie, A, Daly, M, Peltonen, L, Saarela, J 2009, 'MYO9B polymorphisms in multiple sclerosis', European Journal of Human Genetics, vol 17, no. 6, pp. 840-843.

Kere, J 2009, 'Miten perimän muutokset ylläpitävät evoluutiota', Duodecim, vol 2009, no. 125, pp. 1997-1998.

Keski-Rahkonen, A, Hoek, HW, Linna, MS, Raevuori, A, Sihvola, E, Bulik, CM, Rissanen, A, Kaprio, J 2009, 'Incidence and outcomes of bulimia nervosa: a nationwide population-based study', Psychological Medicine, vol 39, no. 5, pp. 823-831.

Keskitalo, K, Broms, UH, Heliövaara, M, Ripatti, SO, Surakka, IL, Perola, M, Pitkäniemi, JM, Peltonen, L, Aromaa, A, Kaprio, J 2009, 'Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15', Human Molecular Genetics, vol 18, no. 20, pp. 4007-4012.

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Kettunen, J, Perola, M, Martin, NG, Cornes, BK, Wilson, SG, Montgomery, GW, Benyamin, B, Harris, JR, Boomsma, D, Willemsen, G, Hottenga, J, Slagboom, PE, Christensen, K, Kyvik, KO, Sørensen, TIA, Pedersen, NL, Magnusson, PKE, Andrew, T, Spector, TD, Widen, E, Silventoinen, K, Kaprio, J, Palotie, A, Peltonen, L, Widen, EIM, GenomEUtwin project 2009, 'Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci', International Journal of Obesity, vol 33, no. 11, pp. 1235-1242.

Kilpinen, H, Ylisaukko-oja, T, Rehnström, K, Gaal, E, Turunen, JA, Kempas, E, Wendt von, L, Varilo, T, Peltonen, L 2009, 'Linkage and linkage disequilibrium scan for autism loci in an extended pedigree from Finland', Human Molecular Genetics, vol 18, no. 15, pp. 2912-2921.

Kolz, M, Peltonen, L, Gieger, C 2009, 'Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations', PLoS Genetics, vol 5, no. 6, pp. e1000504.

Korhonen, T, Kujala, UM, Rose, RJ, Kaprio, J 2009, 'Physical Activity in Adolescence as a Predictor of Alcohol and Illicit Drug Use in Early Adulthood: A Longitudinal Population-Based Twin Study', Twin Research and Human Genetics, vol 12, no. 3, pp. 261-268.

Korhonen, T, Broms, U, Levalahti, E, Koskenvuo, M, Kaprio, J 2009, 'Characteristics and health consequences of intermittent smoking: Long-term follow-up among Finnish adult twins', Nicotine & Tobacco Research, vol 11, no. 2, pp. 148-155.

Korkeila, M, Rissanen, A, Sorensen, TIA, Kaprio, J 2009, 'BMI, Weight Stability and Mortality among Adults without Clinical Co-Morbidities: A 22-Year Mortality Follow-Up in the Finnish Twin Cohort', Obesity facts, vol 2, pp. 344-351.

Koskinen, L, Romanos, J, Kaukinen, K, Mustalahti, K, Korponay-Szabo, I, Barisani, D, Bardella, MT, Ziberna, F, Vatta, S, Szeles, G, Pocsai, Z, Karell, K, Haimila, K, Adany, R, Not, T, Ventura, A, Mäki, M, Partanen, J, Wijmenga, C, Saavalainen, P 2009, 'Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations', Immunogenetics, vol 61, no. 4, pp. 247-256.

Koskinen, L, Einarsdottir, E, Dukes, E, Heap, GAR, Dubois, P, Korponay-Szabo, IR, Kaukinen, K, Kurppa, K, Ziberna, F, Vatta, S, Not, T, Ventura, A, Sistonen, P, Adany, R, Pocsai, Z, Szeles, G, Mäki, M, Kere, J, Wijmenga, C, van Heel, DA, Saavalainen, P 2009, 'Association study of the IL18RAP locus in three European populations with coeliac disease', Human Molecular Genetics, vol 18, no. 6, pp. 1148-1155.

Kotronen, A, Peltonen, M, Hakkarainen, A, Sevastianova, K, Bergholm, R, Johansson, LM, Lundbom, N, Rissanen, A, Groop, L, Orho-Melander, M, Yki-Järvinen, H 2009, 'Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors', Gastroenterology, vol 137, no. 3, pp. 865-872.

Kotronen, A, Seppälä-Lindroos, A, Vehkavaara, S, Bergholm, R, Frayn, KN, Fielding, BA, Yki-Järvinen, H 2009, 'Liver fat and lipid oxidation in humans', Liver International, vol 29, pp. 1439-1446.

Kotronen, A, Yki-Järvinen, H, Aminoff, A, Bergholm, R, Pietiläinen, KH, Westerbacka, J, Talmud, P, Humphries, S, Hamsten, A, Isomaa, B, Groop, L, Orho-Melander, M, Ehrenborg, E, Fisher, R 2009, 'Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts', European Journal of Endocrinology, vol 160, no. 4, pp. 593-602.

Kotronen, A, Velagapudi, VR, Yetukuri, L, Westerbacka, J, Bergholm, R, Ekroos, K, Makkonen, J, Taskinen, M, Oresic, M, Yki-Järvinen, H 2009, 'Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations', Diabetologia, vol 52, pp. 684-690.

Kulmala, J, Viljanen, A, Sipilä, S, Pajala, S, Pärssinen, O, Kauppinen, M, Koskenvuo, M, Kaprio, J, Rantanen, T 2009, 'Poor vision accompanied with other sensory impairments as a predictor of falls in older women', Age and Ageing, vol 38, no. 2, pp. 162-167.

Kurppa, K, Collin, P, Viljamaa, M, Haimila, K, Saavalainen, P, Partanen, J, Laurila, K, Huhtala, H, Paasikivi, K, Mäki, M, Kaukinen, K 2009, 'Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study', Gastroenterology, vol 136, no. 3, pp. 816-23.

Laitala, VS, Kaprio, J, Koskenvuo, M, Räihä, I, Rinne, JO, Silventoinen, K 2009, 'Coffee drinking in middle age is not associated with cognitive performance in old age', American Journal of Clinical Nutrition, vol 90, no. 3, pp. 640-646.

Laitala, V, Kaprio, J, Silventoinen, K 2009, 'Genetics of coffee consumption and its stability', Behavior Genetics, vol 39, pp. 664-665.

Lajunen, H, Keski-Rahkonen, A, Pulkkinen, L, Rose, RJ, Rissanen, A, Kaprio, J 2009, 'Leisure activity patterns and their associations with overweight: a prospective study among adolescents', Journal of Adolescence, vol 32, no. 5, pp. 1089-1103.

Lajunen, H, Kaprio, J, Keski-Rahkonen, A, Rose, RJ, Pulkkinen, L, Rissanen, A, Silventoinen, K 2009, 'Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins', International Journal of Obesity, vol 33, no. 5, pp. 559-567.

Lappalainen, T, Hannelius, U, Salmela, E, von Döbeln, U, Lindgren, CM, Huoponen, K, Savontaus, M, Kere, J, Lahermo, P 2009, 'Population structure in contemporary Sweden: a Y-chromosomal and mitochondrial DNA analysis', Annals of Human Genetics, vol 73, no. 1, pp. 61-73.

Latendresse, SJ, Dick, DM, Edwards, AC, Viken, RJ, Pulkkinen, L, Kaprio, J, Rose, RJ 2009, 'Adolescent drinking transitions and adult alcohol problems', Behavior Genetics, vol 39, pp. 665-666.

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Latendresse, SJ, Rose, RJ, Viken, RJ, Pulkkinen, L, Kaprio, J, Dick, DM 2009, 'Parental socialization and adolescents' alcohol use behaviors: predictive disparities in parents' versus adolescents' perceptions of the parenting environment', Journal of Clinical Child and Adolescent Psychology, vol 38, no. 2, pp. 232-244.

Latvala, A, Castaneda, AE, Perälä, J, Saarni, SI, Aalto-Setälä, T, Lönnqvist, J, Kaprio, J, Suvisaari, J, Tuulio-Henriksson, A 2009, 'Cognitive functioning in substance abuse and dependence: a population-based study of young adults', Addiction, vol 104, no. 9, pp. 1558-1568.

Latvala, A, Tuulio-Henriksson, A, Perälä, J, Saarni, S, Aalto-Setälä, T, Aro, H, Korhonen, T, Koskinen, S, Lönnqvist, J, Kaprio, J, Suvisaari, J 2009, 'Prevalence and correlates of alcohol and other substance use disorders in young adulthood: a population-based study', BMC Psychiatry, vol 9, no. 73, [14, pp. ].

Laudon Meyer, E, Laurell, K, Artto, V, Bendtsen, L, Linde, M, Kallela, M, Tronvik, E, Zwart, J, Jensen, RM, Hagen, K 2009, 'Lateralization in cluster headache: a Nordic multicenter study', Journal of headache and pain, vol 10 (2009), pp. 259-263.

Lebreton, M, Barnes, A, Miettunen, J, Peltonen, L, Ridler, K, Veijola, J, Tanskanen, P, Suckling, J, Järvelin, M, Jones, PB, Isohanni, M, Bullmore, ET, Murray, GK 2009, 'The brain structural disposition to social interaction', European Journal of Neuroscience, vol 29, no. 11, pp. 2247-2252.

Leskelä, P, Ukkola, O, Vartiainen, J, Rönnemaa, T, Kaprio, J, Bouchard, C, Kesäniemi, YA 2009, 'Fasting plasma total ghrelin concentrations in monozygotic twins discordant for obesity', Metabolism, clinical and experimental, vol 58, no. 2, pp. 174-179.

Leskinen, T, Waller, K, Mutikainen, S, Aaltonen, S, Ronkainen, PHA, Alen, M, Sipilä, S, Kovanen, V, Perhonen, M, Pietiläinen, KH, Cheng, S, Suominen, H, Kainulainen, H, Kaprio, J, Kujala, UM 2009, 'Effects of 32-Year Leisure Time Physical Activity Discordance in Twin Pairs on Health (TWINACTIVE Study): Aims, Design and Results for Physical Fitness', Twin Research and Human Genetics, vol 12, no. 1, pp. 108-117.

Leskinen, T, Sipilä, S, Alen, M, Cheng, S, Pietiläinen, KH, Usenius, J, Suominen, H, Kovanen, V, Kainulainen, H, Kaprio, J, Kujala, UM 2009, 'Leisure-time physical activity and high-risk fat: a longitudinal population-based twin study', International Journal of Obesity, vol 33, no. 11, pp. 1211-1218.

Lindgren, CM, Heid, IM, Randall, JC, Lamina, C, Steinthorsdottir, V, Qi, L, Speliotes, EK, Thorleifsson, G, Willer, CJ, Herrera, BM, Jackson, AU, Lim, N, Scheet, P, Soranzo, N, Amin, N, Aulchenko, YS, Chambers, JC, Drong, A, Luan, J, Lyon, HN, Rivadeneira, F, Sanna, S, Timpson, NJ, Zillikens, MC, Zhao, JH, Almgren, P, Bandinelli, S, Bennett, AJ, Bergman, RN, Bonnycastle, LL, Bumpstead, SJ, Chanock, SJ, Cherkas, L, Chines, P, Coin, L, Cooper, C, Crawford, G, Doering, A, Dominiczak, A, Doney, ASF, Ebrahim, S, Elliott, P, Erdos, MR, Estrada, K, Ferrucci, L, Fischer, G, Forouhi, NG, Gieger, C, Grallert, H, Groves, CJ, Grundy, S, Guiducci, C, Hadley, D, Hamsten, A, Havulinna, AS, Hofman, A, Holle, R, Holloway, JW, Illig, T, Isomaa, B, Jacobs, LC, Jameson, K, Jousilahti, P, Karpe, F, Kuusisto, J, Laitinen, J, Lathrop, GM, Lawlor, DA, Mangino, M, McArdle, WL, Meitinger, T, Morken, MA, Morris, AP, Munroe, P, Narisu, N, Nordstrom, A, Nordstroem, P, Oostra, BA, Palmer, CNA, Payne, F, Peden, JF, Prokopenko, I, Renstroem, F, Ruokonen, A, Salomaa, V, Sandhu, MS, Scott, LJ, Scuteri, A, Silander, K, Song, K, Yuan, X, Stringham, HM, Swift, AJ, Tuomi, T, Uda, M, Vollenweider, P, Waeber, G, Wallace, C, Walters, GB, Weedon, MN, Witteman, JCM, Zhang, C, Zhang, W, Caulfield, MJ, Collins, FS, Smith, GD, Day, INM, Franks, PW, Hattersley, AT, Hu, FB, Jarvelin, M, Kong, A, Kooner, JS, Laakso, M, Lakatta, E, Mooser, V, Morris, AD, Peltonen, L, Samani, NJ, Spector, TD, Strachan, DP, Tanaka, T, Tuomilehto, J, Uitterlinden, AG, van Duijn, CM, Wareham, NJ, Watkins, H, Waterworth, DM, Boehnke, M, Deloukas, P, Groop, L, Hunter, DJ, Thorsteinsdottir, U, Schlessinger, D, Wichmann, H-, Frayling, TM, Abecasis, GR, Hirschhorn, JN, Loos, RJF, Stefansson, K, Mohlke, KL, Barroso, IS, McCarthy, MI, Wellcome Trust Case Control Consor, GIANT Consortium, PROCARDIS Consortia 2009, 'Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution', PLoS Genetics, vol 5, no. 6, pp. -.

Lundbom, J, Heikkinen, S, Fielding, B, Hakkarainen, A, Taskinen, M, Lundbom, N 2009, 'PRESS echo time behavior of triglyceride resonances at 1.5 T: detecting -3 fatty acids in adipose tissue in vivo', Journal of Magnetic Resonance, vol 201, no. 1, pp. 39-47.

Lyssenko, V, Nagorny, CLF, Erdos, MR, Wierup, N, Jonsson, A, Spegel, P, Bugliani, M, Saxena, R, Fex, M, Pulizzi, N, Isomaa, B, Tuomi, T, Nilsson, P, Kuusisto, J, Tuomilehto, J, Boehnke, M, Altshuler, D, Sundler, F, Eriksson, JG, Jackson, AU, Laakso, M, Marchetti, P, Watanabe, RM, Mulder, H, Groop, L 2009, 'Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion', Nature Genetics, vol 41, no. 1, pp. 82-88.

Lähteenmäki, S, Aalto-Setälä, T, Suokas, JT, Saarni, SE, Perälä, J, Saarni, SI, Aro, H, Lönnqvist, J, Suvisaari, J 2009, 'Validation of the Finnish version of the SCOFF questionnaire among young adults aged 20 to 35 years', BMC Psychiatry, vol 9, no. 5, pp. 1-8.

Ma, H, Leskinen, T, Alen, M, Cheng, S, Sipila, S, Heinonen, A, Kaprio, J, Suominen, H, Kujala, UM 2009, 'Long-Term Leisure Time Physical Activity and Properties of Bone: A Twin Study', Journal of Bone and Mineral Research, vol 24, no. 8, pp. 1427-1433.

Makkonen, J, Pietiläinen, KH, Rissanen, A, Kaprio, J, Yki-Järvinen, H 2009, 'Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins', Journal of Hepatology, vol 50, no. 5, pp. 1035-1042.

Marjamaa, A, Salomaa, V, Newton-Cheh, C, Porthan, K, Reunanen, A, Karanko, H, Jula, A, Lahermo, P, Väänänen, H, Toivonen, L, Swan, H, Viitasalo, M, Nieminen, MS, Peltonen, L, Oikarinen, L, Palotie, A, Kontula, K 2009, 'High prevalence of four long QT syndrome founder mutations in the Finnish population', Annals of Medicine, vol 41, no. 3, pp. 234-240.

Marjamaa, A, Laitinen-Forsblom, P, Lahtinen, A, Viitasalo, M, Toivonen, L, Kontula, K, Swan, H 2009, 'Search for cardiac calcium cycling gene mutations in familial ventricular arrhythmias resembling catecholaminergic polymorphic ventricular tachycardia', BMC Medical Genetics, vol 10, no. 12.

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Marjamaa, A, Newton-Cheh, C, Porthan, K, Reunanen, A, Lahermo, P, Vaananen, H, Jula, A, Karanko, H, Swan, H, Toivonen, L, Nieminen, MS, Viitasalo, M, Palotie, L, Oikarinen, L, Palotie, A, Kontula, K, Salomaa, V 2009, 'Common candidate gene variants are associated with QT interval duration in the general population', Journal of Internal Medicine, vol 265, no. 4, pp. 448-458.

Markkula, R, Järvinen, P, Leino-Arjas, P, Koskenvuo, M, Kalso, E, Kaprio, J 2009, 'Clustering of symptoms associated with fibromyalgia in a Finnish Twin Cohort', European journal of pain., vol 13, no. 7, pp. 744-750.

Massinen, S, Tammimies, K, Tapia-Paez, I, Matsson, H, Hokkanen, M, Söderberg, O, Landegren, U, Castren, E, Gustafsson, J, Treuter, E, Kere, J 2009, 'Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia', Human Molecular Genetics, vol 18, no. 15, pp. 2802-2812.

McCarroll, SA, Bradner, JE, Turpeinen, H, Volin, L, Martin, PJ, Chilewski, SD, Antin, JH, Lee, SJ, Ruutu, T, Storer, B, Warren, EH, Zhang, B, Zhao, LP, Ginsburg, D, Soiffer, RJ, Partanen, J, Hansen, JA, Ritz, J, Palotie, A, Altshuler, D 2009, 'Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease', Nature Genetics, vol 41, pp. 1341-1344.

McEvoy, BP, Montgomery, GW, McRae, AF, Ripatti, S, Perola, M, Spector, TD, Cherkas, L, Ahmadi, KR, Boomsma, D, Willemsen, G, Hottenga, JJ, Pedersen, NL, Magnusson, PKE, Kyvik, KO, Christensen, K, Kaprio, J, Heikkilä, K, Palotie, A, Widen, E, Muilu, J, Syvänen, A, Liljedahl, U, Hardiman, O, Cronin, S, Peltonen, L, Martin, NG, Visscher, PM 2009, 'Geographical structure and differential natural selection among North European populations', Genome Research, vol 19, no. 5, pp. 804-814.

Meex, SJ, Weissglas-Volkov, D, van der Kallen, CJ, Thuerauf, DJ, van Greevenbroek, MM, Schalkwijk, CG, Stehouwer, CD, Feskens, EJ, Heldens, L, Ayoubi, TA, Hofker, MH, Wouters, BG, Vlietinck, R, Sinsheimer, JS, Taskinen, M, Kuusisto, J, Laakso, M, de Bruin, TW, Päivi, P, Glembotski, CC 2009, 'The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 29, pp. 1322-1327.

Mellersh, CS, McLaughlin, B, Ahonen, S, Pettitt, L, Lohi, H, Barnett, KC 2009, 'Mutation in HSF4 is associated with hereditary cataract in the Australian Shepherd', Veterinary Ophthalmology, vol 12, no. 6, pp. 372-378.

Mero, IL, Lorentzen, AR, Ban, M, Smestad, C, Celius, EG, Aarseth, JH, Myhr, KM, Link, J, Hillert, J, Olsson, T, Kockum, I, Masterman, T, Oturai, A, Sondergaard, HB, Sellebjerg, F, Saarela, J, Kemppinen, A, Spurkland, A, Lie, BA, Harbo, H 2009, 'The TYK2 gene is associated with susceptibility to multiple sclerosis', Multiple Sclerosis, vol 15, pp. S186-S186.

Mikkola, TM, Sipilä, S, Rantanen, T, Sievänen, H, Suominen, H, Tiainen, K, Kaprio, J, Koskenvuo, M, Kauppinen, M, Heinonen, A 2009, 'Muscle Cross-Sectional Area and Structural Bone Strength Share Genetic and Environmental Effects in Older Women', Journal of Bone and Mineral Research, vol 24, no. 2, pp. 338-345.

Mustelin, LM, Silventoinen, K, Pietiläinen, K, Rissanen, A, Kaprio, J 2009, 'Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins', International Journal of Obesity, vol 33, no. 1, pp. 29-36.

Mutikainen, S, Perhonen, M, Alen, M, Leskinen, T, Karjalainen, J, Rantanen, T, Kaprio, J, Kujala, UM 2009, 'Effects of long-term physical activity on cardiac structure and function: A twin study', Journal of Sports Science and Medicine, vol 8, no. 4, pp. 533-542.

Mutikainen, S, Ortega-Alonso, A, Alen, M, Kaprio, J, Karjalainen, J, Rantanen, T, Kujala, UM 2009, 'Genetic influences on resting electrocardiographic variables in older women: a twin study', Annals of Noninvasive Electrocardiology, vol 14, no. 1, pp. 57-64.

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Waller, K, Kujala, UM, Rantanen, T, Kauppinen, M, Silventoinen, K, Koskenvuo, M, Kaprio, J 2010, 'Physical activity, morbidity and mortality in twins: a 24-year prospective follow-up', European Journal of Epidemiology, vol 25, no. 10, pp. 731-739.

Waller, K, Kaprio, J, Lehtovirta, M, Silventoinen, K, Koskenvuo, M, Kujala, UM 2010, 'Leisure-time physical activity and type 2 diabetes during a 28 year follow-up in twins', Diabetologia, vol 53, no. 12, pp. 2531-2537.

Walters, RG, Jacquemont, S, Valsesia, A, de Smith, AJ, Martinet, D, Andersson, J, Falchi, M, Chen, F, Andrieux, J, Lobbens, S, Delobel, B, Stutzmann, F, Moustafa, JSE, Chevre, J-, Lecoeur, C, Vatin, V, Bouquillon, S, Buxton, JL, Boute, O, Holder-Espinasse, M, Cuisset, J-, Lemaitre, M-, Ambresin, A-, Brioschi, A, Gaillard, M, Giusti, V, Fellmann, F, Ferrarini, A, Hadjikhani, N, Campion, D, Guilmatre, A, Goldenberg, A, Calmels, N, Mandel, J-, Le Caignec, C, David, A, Isidor, B, Cordier, M-, Dupuis-Girod, S, Labalme, A, Sanlaville, D, Beri-Dexheimer, M, Jonveaux, P, Leheup, B, Ounap, K, Bochukova, EG, Henning, E, Keogh, J, Ellis, RJ, MacDermot, KD, van Haelst, MM, Vincent-Delorme, C, Plessis, G, Touraine, R, Philippe, A, Malan, V, Mathieu-Dramard, M, Chiesa, J, Blaumeiser, B, Kooy, RF, Caiazzo, R, Pigeyre, M, Balkau, B, Sladek, R, Bergmann, S, Mooser, V, Waterworth, D, Reymond, A, Vollenweider, P, Waeber, G, Kurg, A, Palta, P, Esko, T, Metspalu, A, Nelis, M, Elliott, P, Hartikainen, A-, McCarthy, MI, Peltonen, L, Carlsson, L, Jacobson, P, Sjostrom, L, Huang, N, Hurles, ME, O'Rahilly, S, Farooqi, IS, Maennik, K, Jarvelin, M-, Pattou, F, Meyre, D, Walley, AJ, Coin, LJM, Blakemore, AIF, Froguel, P, Beckmann, JS 2010, 'A new highly penetrant form of obesity due to deletions on chromosome 16p11.2', Nature, vol 463, pp. 671-675.

Wang, TJ, Zhang, F, Richards, JB, Kestenbaum, B, van Meurs, JB, Berry, D, Kiel, DP, Streeten, EA, Ohlsson, C, Koller, DL, Peltonen, L, Cooper, JD, O'Reilly, PF, Houston, DK, Glazer, NL, Vandenput, L, Peacock, M, Shi, J, Rivadeneira, F, McCarthy, MI, Anneli, P, de Boer, IH, Mangino, M, Kato, B, Smyth, DJ, Booth, SL, Jacques, PF, Burke, GL, Goodarzi, M, Cheung, C, Wolf, M, Rice, K, Goltzman, D, Hidiroglou, N, Ladouceur, M, Wareham, NJ, Hocking, LJ, Hart, D, Arden, NK, Cooper, C, Malik, S, Fraser, WD, Hartikainen, A, Zhai, G, Macdonald, HM, Forouhi, NG, Loos, RJF, Reid, DM, Hakim, A, Dennison, E, Liu, Y, Power, C, Stevens, HE, Jaana, L, Vasan, RS, Soranzo, N, Bojunga, J, Psaty, BM, Lorentzon, M, Foroud, T, Harris, TB, Hofman, A, Jonsson, J, Cauley, JA, Uitterlinden, AG, Gibson, Q, Jarvelin, M, Karasik, D, Siscovick, DS, Econs, MJ, Kritchevsky, SB, Florez, JC, Todd, JA, Dupuis, J, Hyppoenen, E, Spector, TD 2010, 'Common genetic determinants of vitamin D insufficiency: a genome-wide association study', Lancet, vol 376, pp. 180-188.

Waterworth, DM, Ricketts, SL, Song, K, Chen, L, Zhao, JH, Ripatti, S, Aulchenko, YS, Zhang, W, Yuan, X, Lim, N, Luan, J, Ashford, S, Wheeler, E, Young, EH, Hadley, D, Thompson, JR, Braund, PS, Johnson, T, Struchalin, M, Surakka, I, Luben, R, Khaw, K, Rodwell, SA, Loos, RJF, Boekholdt, SM, Inouye, M, Deloukas, P, Elliott, P, Schlessinger, D, Sanna, S, Scuteri, A, Jackson, A, Mohlke, KL, Tuomilehto, J, Roberts, R, Stewart, A, Kesaeniemi, YA, Mahley, RW, Grundy, SM, McArdle, W, Cardon, L, Waeber, G, Vollenweider, P, Chambers, JC, Boehnke, M, Abecasis, GR, Salomaa, V, Jaervelin, M, Ruokonen, A, Barroso, I, Epstein, SE, Hakonarson, HH, Rader, DJ, Reilly, MP, Witteman, JCM, Hall, AS, Samani, NJ, Strachan, DP, Barter, P, van Duijn, CM, Kooner, JS, Peltonen, L, Wareham, NJ, McPherson, R, Mooser, V, Sandhu, MS, Wellcome Trust Case Control Consor 2010, 'Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 30, pp. 2264-U566.

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Wedenoja, J, Tuulio-Henriksson, A, Suvisaari, J, Loukola, A, Paunio, T, Partonen, T, Varilo, T, Lönnqvist, J, Peltonen, L 2010, 'Replication of Association Between Working Memory and Reelin, a Potential Modifier Gene in Schizophrenia', Biological Psychiatry, vol 67, no. 10, pp. 983-991.

Wennerstad, KM, Silventoinen, K, Tynelius, P, Bergman, L, Kaprio, J, Rasmussen, F 2010, 'Associations between IQ and cigarette smoking among Swedish male twins', Social Science & Medicine, vol 70, pp. 575-581.

Widen, E, Ripatti, S, Cousminer, DL, Surakka, I, Lappalainen, T, Jaervelin, M, Eriksson, JG, Raitakari, O, Salomaa, V, Sovio, U, Hartikainen, A, Pouta, A, McCarthy, MI, Osmond, C, Kajantie, E, Lehtimaki, T, Viikari, J, Kahonen, M, Tyler-Smith, C, Freimer, N, Hirschhorn, JN, Peltonen, L, Palotie, A 2010, 'Distinct Variants at LIN28B Influence Growth in Height from Birth to Adulthood', American Journal of Human Genetics, vol 86, no. 5, pp. 773-782.

Wienke, A, Ripatti, S, Palmgren, J, Yashin, A 2010, 'A bivariate survival model with compound Poisson frailty', Statistics in Medicine, vol 29, pp. 275-283.

Wilbe, M, Jokinen, P, Truve, K, Seppälä, EH, Karlsson, EK, Biagi, T, Hughes, A, Bannasch, D, Andersson, G, Hansson-Hamlin, H, Lohi, H, Lindblad-Toh, K 2010, 'Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex', Nature Genetics, vol 42, no. 3, pp. 250-254.

Yasuno, K, Bilguvar, K, Bijlenga, P, Low, S, Krischek, B, Auburger, G, Simon, M, Krex, D, Arlier, Z, Nayak, N, Ruigrok, YM, Niemela, M, Tajima, A, Fraunberg, MVUZ, Doczi, T, Wirjatijasa, F, Hata, A, Blasco, J, Oszvald, A, Kasuya, H, Zilani, G, Schoch, B, Singh, P, Stueer, C, Risselada, R, Beck, J, Sola, T, Ricciardi, F, Aromaa, A, Illig, T, Schreiber, S, van Duijn, CM, van den Berg, LH, Perret, C, Proust, C, Roder, C, Ozturk, AK, Gaal, E, Berg, D, Geisen, C, Friedrich, CM, Summers, P, Frangi, AF, State, MW, Wichmann, HE, Breteler, MMB, Wijmenga, C, Mane, S, Peltonen, L, Elio, V, Sturkenboom, MCJM, Lawford, P, Byrne, J, Macho, J, Sandalcioglu, EI, Meyer, B, Raabe, A, Steinmetz, H, Ruefenacht, D, Jaaskelainen, JE, Hernesniemi, J, Rinkel, GJE, Zembutsu, H, Inoue, I, Palotie, A, Cambien, F, Nakamura, Y, Lifton, RP, Guenel, M 2010, 'Genome-wide association study of intracranial aneurysm identifies three new risk loci', Nature Genetics, vol 42, pp. 420-69.

Yetukuri, L, Soderlund, S, Koivuniemi, A, Seppanen-Laakso, T, Niemela, PS, Hyvonen, M, Taskinen, M, Vattulainen, IT, Jauhiainen, M, Oresic, M 2010, 'Composition and lipid spatial distribution of HDL particles in subjects with low and high HDL-cholesterol', Journal of Lipid Research, vol 51, no. 8, pp. 2341-2351.

Ylinen, S, Uther, M, Latvala, A, Vepsäläinen, S, Iverson, P, Akahane-Yamada, R, Näätänen, R 2010, 'Training the Brain to Weight Speech Cues Differently: A Study of Finnish Second-language Users of English', Journal of Cognitive Neuroscience, vol 22, no. 6, pp. 1319-1332.

Zangerl, B, Wickstrom, K, Slavik, J, Lindauer, SJ, Ahonen, S, Schelling, C, Lohi, H, Guziewicz, KE, Aguirre, GD 2010, 'Assessment of canine BEST1 variations identifies new mutations and establishes an independent bestrophinopathy model (cmr3)', Molecular Vision, vol 16, pp. 2791-2804.

Zhernakova, A, Elbers, CC, Ferwerda, B, Romanos, J, Trynka, G, Dubois, PC, de Kovel, CGF, Franke, L, Oosting, M, Barisani, D, Bardella, MT, Joosten, LAB, Saavalainen, P, van Heel, DA, Catassi, C, Netea, MG, Wijmenga, C, Finnish Celiac Dis Study Grp 2010, 'Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection', American Journal of Human Genetics, vol 86, no. 6, pp. 970-977.

Öckinger, J, Stridh, P, Beyeen, AD, Lundmark, F, Seddighzadeh, M, Oturai, AB, Sørensen, PS, Lorentzen, ÅR, Celius, EG, Leppä, VM, Koivisto, K, Tienari, P, Alfredsson, L, Padyukov, L, Hillert, J, Kockum, I, Jagodic, M, Olsson, T 2010, 'Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis', Genes and Immunity, vol 11, no. 2, pp. 142-154.

A2 Review in scientific journal

2005 Lohi, HT 2005, 'Starch-like polyglucosan formation in neuronal dendrites in the Lafora form of human epilepsy: a theory of pathogenesis', Biologia (Bratislava).

Nevalainen, E, Lappalainen, P 2005, 'Twinfilin-2', UCSD-Nature Molecule pages, vol 2005.

Nevalainen, E, Lappalainen, P 2005, 'Twinfilin-1', UCSD-Nature Molecule pages.

Peterson, P, Palotie, L 2005, 'Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: new views on molecular basis of autoimmunity', Journal of Autoimmunity, vol 25, no. Suppl, pp. 49-55.

2006 Halme, L, Paavola-Sakki, P, Turunen, U, Lappalainen, M, Färkkilä, M, Kontula, K 2006, 'Family and twin studies in inflammatory bowel disease: [review]', World Journal of Gastroenterology, vol 12, no. 23, pp. 3668-3672.

Hennah, W, Thomson, P, Palotie, L, Porteous, D 2006, 'Beyond schizophrenia: The role of DISC1 in major mental illness', Schizophrenia bulletin, vol 32, pp. 409-416.

Kinnunen, T, Korhonen, T 2006, 'Voidaanko liikunnalla auttaa naisia tupakoinnin lopettamisessa?', Liikunta & Tiede, vol 43, pp. 57-62.

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Naukkarinen, J, Enholm, C, Palotie, L 2006, 'Genetics of familial combined hyperlipidemia', Current Opinion in Lipidology, vol 17, no. 3, pp. 285-290.

2007 Franceschi, C, Bezrukov, V, Blanche, H, Bolund, L, Christensen, K, de Benedictis, G, Deiana, L, Gonos, E, Hervonen, A, Yang, H, Jeune, B, Kirkwood, T, Kristensen, P, Pelicci, P, Palotie, L, Poulain, M, Rea, I, Remacle, J, Robine, J, Scheiber, S, Sikora, E, Slagboom, P, Spazzafumo, L, Stazi, M, Toussaint, O, Vaupel, J 2007, 'Genetics of Healthy Aging in Europe – the EU-integrated Project GEHA', Annals of the New York Academy of Sciences, vol 2007/1100, pp. 21-45.

Nussbaum, R, Palotie, L 2007, 'Genetics of disease: recent advances in the genetics of human disease offer something new for every scientific interest : editorial overview', Current Opinion in Genetics & Development, vol 17, pp. 163-165.

2008 Groop, LC, Tuomi, T, Isomaa, B, Lyssenko, V, Orho-Melander, M, Taskinen, M 2008, 'The Botnia study – on the trail of type 2 diabetes', International diabetes monitor., vol 20, no. 2, pp. 73-81.

Korhonen, T, Haukkala, A, Koivumaa-Honkanen, H, Kinnunen, T 2008, 'Tupakointi ja masennus', Duodecim, vol 124, no. 8, pp. 899-995.

2009 Kandolin, R, Lehtonen, J, Schildt, J, Graner, M, Salmenkivi, K, Ahonen, A, Karhumäki, L, Kupari, M 2009, 'Sydänsarkoidoosi: [katsaus]', Duodecim, vol 125, no. 21, pp. 2344-2350.

2010 Hiukka, A, Maranghi, M, Matikainen, N, Taskinen, M 2010, 'PPAR alpha: an emerging therapeutic target in diabetic microvascular damage', Nature reviews. Endocrinology, vol 6, pp. 454-463.

Ho, MK, Goldman, D, Heinz, A, Kaprio, J, Kreek, MJ, Li, MD, Munafo, MR, Tyndale, RF 2010, 'Breaking barriers in the genomics and pharmacogenetics of drug addiction', Clinical Pharmacology and Therapeutics, vol 88, no. 6, pp. 779-791.

Kere, J 2010, 'Genetics of complex disorders', Biochemical and Biophysical Research Communications, vol 396, no. 1, pp. 143-146.

Kinnunen , T, Korhonen, T, Craft, L, Perna, F 2010, 'Treating tobacco dependence in women: is exercise intervention a solution?', Journal of Sport and Exercise Psychology, vol 8, no. 1, pp. 48-60.

Lutkenhoff, ES, van Erp, TG, Thomas, MA, Therman, S, Manninen, M, Huttunen, MO, Kaprio, J, Lönnqvist, J, O'Neill, J, Cannon, TD 2010, 'Proton MRS in twin pairs discordant for schizophrenia', Molecular Psychiatry, vol 15, no. 3, pp. 308-318.

Silventoinen, K, Rokholm, B, Kaprio, J, Sorensen, TIA 2010, 'The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies', International Journal of Obesity, vol 34, no. 1, pp. 29-40.

Wedenoja, SJ, Höglund, PA, Holmberg, C 2010, 'Review article: the clinical management of congenital chloride diarrhoea', Alimentary Pharmacology & Therapeutics, vol 31, pp. 477-485.

A3 Contribution to book/other compilations (refereed)

2005 Kaprio, J, Marttila, R 2005, 'Demographic trends in Nordic Countries', Multiple pregnancy, Taylor & Francis, London, pp. 22-25.

Kere, J 2005, 'Genetic diagnostics: what can it predict', in I Jónsdóttir (ed.), PGD and Embryo Selection. Report from an International Conference on Preimplantation Genetic Diagnostics and Embryo Selection., vol. 2005, Nordic Council of Ministers, Copenhagen, pp. 22-27.

Kere, J 2005, 'Mapping genes for asthma and psoriasis', in G Bock, J Goode (eds), Genetics of Autoimmunity. Novartis Foundation Symposium 267., Novartis Foundation Symposia, Novartis Foundation, pp. 46-52.

Reunanen, A, Kattainen, A, Jauhiainen, M, Jula, A, Kaaja, R, Kesäniemi, A, Kukkonen- Harjula, K, Kähönen, M, Laakso, M, Luoto, R, Majahalme, S, Mykkänen, L, Nieminen, M, Rapola, J, Salomaa, V, Taskinen, M, Tuomilehto, J, Varpula, M, Vartiainen, E 2005, 'Verenkiertoelinten sairaudet ja diabetes', Nuorten aikuisten terveys. Terveys 2000 -tutkimuksen perustulokset 18-29 -vuotiaiden terveydestä ja siihen liittyvistä tekijöistä., pp. 79-81.

2006 Ferrari, M, Haan, J, Palotie, A 2006, 'Genetics of Migraine', in J Olsen, P Goadsby, N Ramadan, P Tfelt-Hansen, KMA Welch (eds), The Headaches, Philadelphia, Lippincott Williams & Wilkins,, pp. 251-267.

Kallela, M, Lindsberg, PJ 2006, 'Tajuton potilas', Lääkärin käsikirja, Duodecim, Helsinki, pp. 1236-1238.

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Kallela, M 2006, 'Kohtausoireen selvittely', Lääkärin käsikirja, Duodecim, Helsinki, pp. 1239-1242.

Kaprio, J 2006, 'Social behaviors and health in twins: the FinnTwin studies', Socioemotional development and health from adolescence to adulthood, Cambridge University Press, Cambridge, pp. 76-92.

Lindsberg, PJ, Kallela, M 2006, 'Tajuttoman potilaan hoito', Tehohoito-opas, Duodecim, Helsinki, pp. 159.

Lindsberg, PJ, Kallela, M 2006, 'Tajuttomuuden etiologia ja diagnostiikka', Tehohoito-opas, Duodecim, Helsinki, pp. 154-158.

Lindsberg, PJ, Kallela, M 2006, 'Status epilepticuksen hoito', Tehohoito-opas, Duodecim, Helsinki, pp. 162-166.

Lindsberg, PJ, Kallela, M 2006, 'Status epilepticuksen diagnostiikka', Tehohoito-opas, Duodecim, Helsinki, pp. 159-161.

Palotie, A, Tuomi, T, Wessman, M 2006, 'Monitekijäisten sairauksien genetiikka', in H Kääriäinen, A Palotie (eds), Perinnöllisyyslääketiede, Kustannus Oy Duodecim.

Silventoinen, K, Lahelma, E, Kaprio, J 2006, 'Self-rated health: precursors and implications', Socioemotional development and health from adolescence to adulthood, Cambridge University Press, Cambridge, pp. 146-172.

Yki-Järvinen, H, Tuomi, T 2006, 'Diabeteksen määritelmä, erotusdiagnoosi ja luokitus', Lääkärin käsikirja, Duodecim, Helsinki, pp. 788-789.

2007 Kallela, M 2007, 'Status epilepticus', Therapia Fennica, Kandidaattikustannus Lääketieteen kandidaattiseura, [Helsinki], pp. 586-591.

Kallela, M 2007, 'Tajunnanmenetyskohtaus', Therapia Fennica, Kandidaattikustannus Lääketieteen kandidaattiseura, [Helsinki] , pp. 559-562.

Kallela, M 2007, 'Temporaaliarteriitti', Therapia Fennica, Kandidaattikustannus Lääketieteen kandidaattiseura, [Helsinki], pp. 548-551.

2008 Kallela, M 2008, 'Kohtausoireen selvittely', Lääkärin käsikirja, Duodecim, Helsinki, pp. 1277-79.

Kallela, M, Lindsberg, PJ 2008, 'Tajuton potilas', Lääkärin käsikirja, Duodecim, Helsinki, pp. 1273-1275.

Kaprio, J, Harris, JR 2008, 'Twin studies', Obesity, Informa healthcare, New York, pp. 39-47.

Kinnunen, T, Korhonen, T, Miesmaa, P, Terwal, DM 2008, 'Tobacco use and dependence: health impact on women', Smoking and women's health, Nova Science Publishers, New York, pp. 69-108.

Kontula, K 2008, 'Hypofosfatemia', Akuuttihoito-opas / toimittajat. Erkki Elonen, Markku Mäkijärvi, Matti Vuoristo., Duodecim, Helsinki, pp. 396-398.

2009 Jackson, KM, Sher, KJ, Rose, RJ, Kaprio, J 2009, 'Trajectories of tobacco use from adolescence to adulthood: are the most informative phenotypes tobacco specific?', in EBGESTBBLCDVCCLKAP (ed.), Phenotypes and endophenotypes, NCI tobacco control monograph series, National Institutes of Health,, Washington, pp. 289-335.

Kere, J 2009, 'Neuropeptide S receptor 1: an asthma susceptibility gene', in R Pawankar, S Holgate, R Rosenwasser (eds) , Allergy Frontiers. Future Perspectives, Vol 6., vol. 2009, Springer, Tokyo, pp. 191-205.

Rose, RJ, Broms, U, Korhonen, T, Dick, DM, Kaprio, J 2009, 'Genetics of smoking behavior', in EYK (ed.), Handbook of behavior genetics, Springer, New York, pp. 411-432.

Tiira, KA, Primmer, CR 2009, 'Genetic diversity and fitness-related traits in endangered salmonids', in EBGB.[A (ed.), Population genetics for animal conservation, Conservation biology series (Cambridge, England), Cambridge University Press, Cambridge, UK, pp. 241-268.

A4 Article in conference publication (refereed)

2005 Agrawal, A, Pergadia, ML, Saccone, SF, Lynskey, MT, Dick, DM, Grant, JD, Wang, JC, Montgomery, GW, Todorov, A, Rice, JP, Kaprio, J, Martin, NG, Heath, AC, Madden, PA 2005, A genome-wide linkage scan for illicit drug phenotypes in Australian adults from the Nicotine Addiction Genetics (NAG) Project,, American journal of medical genetics. Part B, Neuropsychiatric genetics 138B WILEY-LISS..

2006 Kere, J 2006, Overview of the SLC26 family and associated diseases,.

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2007 Saavalainen, P 2007, Genetics of celiac disease,, Paper presented at International Coeliac Disease Meeting (2007 : Maribor, Slovenia), Maribor..

2008 Heikkilä, O, Lundbom, N, Timonen, M, Groop, P, Heikkinen, S, Mäkimattila, S 2008, 'Decreased glucose transport into the thalamus in type 1 diabetes', in Abstract Book 2008, pp. S283-S283.

2009 Lohi, H, Seppälä, E, Jokinen, T, Kyöstilä, K, Forman, O, Mellersh, C, But, A, Jokinen, P, Baranowska, I, Berendt, M, Gullov, CH, Fredholm, M, Sizinauskas, C, Viitmaa, R, Short, A, Ollier, W, Hitte, C, Grall, A, Andre, C, Minassian, B, Ekenstedt, K, Patterson, E, Drogemuller, C, Leeb, T, Lindblad-Toh, K, Johnson, G 2009, GENETIC ANALYSES IN DIFFERENT BREEDS IDENTIFIES A NOVEL MUTATION AND SEVERAL NEW LOCI IN CANINE FOCAL IDIOPATHIC EPILEPSIES,, Paper presented at Annual Meeting of the American Epilepsy Society. Epilepsia 50 Suppl. 11 WILEY-BLACKWELL PUBLISHING, INC..

2010 Amemori, M, Kinnunen, T, Michie, S, Korhonen, T, Murtomaa, H 2010, Implementing tobacco use cessation guideline: what drives provider behaviour?,, Paper presented at IADR, Barcelona, Spain..

Kinnunen, T, Amemori, M, Korhonen, T, Murtomaa, H 2010, Provider behavior change and tobacco use cessation delivery in dentistry,, Paper presented at IADR, Barcelona, Spain..

Murtomaa, H, Rintakoski, K, Kaprio, J, Ahlberg, JP 2010, Tobacco use and reported bruxism in young adult twins,, Paper presented at IADR, Barcelona, United States..

B1 Unrefereed journal article

2005 Hennah, W, Tuulio-Henriksson, A, Paunio, T, Ekelund, J, Kilpinen, H, Palo, OM, Silander, K, Partonen, T, Lönnqvist, J, Peltonen, L 2005, 'Two biologically interacting genes, DISC1 and NDE1, associate with schizophrenia and visual working memory functions: [Abstract, XIII World Congress on Psychiatric Genetics 2005]', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 138B, no. 1, pp. 123-123.

Kahri, J 2005, 'Rabdomyolyysi ja statiinien interaktiot: kaksi potilastapausta', TABU : lääkeinformaatiota Lääkelaitokselta, vol 12, no. 3, pp. 4-7.

Kallela, M 2005, 'Krooninen migreeni: [katsausartikkeli]', Suomen lääkärilehti , vol 60, no. 42, pp. 4237- 4242.

Kaprio, J 2005, 'Role of familial and genetic factors in behavioural change', Psychology Bulletin, vol 20, pp. 127-128.

Sipilä, R, Hiltunen, T, Näveri, H 2005, 'Akuutti sydäninfarkti rankan lumisateen jälkeen', Duodecim, vol 121, no. 2, pp. 181-183.

Tran, D, Bachman, P, Kim, J, Glahn, DC, Therman, S, Manninen, M, Huttunen, M, Lönnqvist, J, Kaprio, J, Näätänen, R, Konotchick, T, Quintero, M, Cannon, TD 2005, 'Resting EEG power in schizophrenia patients, their non-schizophrenic cotwins, and control twins: [Abstract of the XX International congress on Schizophrenia Research]', Schizophrenia bulletin, vol 31, no. 2, pp. 465-465.

Tuomi, T 2005, 'Hankalahoitoinen astma ja hypokalemia', Duodecim, vol 121, no. 6, pp. 641-643.

Tuomi, T 2005, 'Diabeetikko joka näki hämähäkkejä', Duodecim, vol 121, no. 6, pp. 2319-2320.

Tuomi, T 2005, 'Miksi tyypin 1 diabeteksen hoitotasapaino ei parane?: [pääkirjoitus]', Duodecim, vol 121, pp. 817-819.

Tuomi, T 2005, 'LADA in adults: how does it differ from type 1 diabetes? : [leading articles]', International diabetes monitor., vol 17, no. 2, pp. 1-5.

Verkasalo, PK, Lillberg, K, Stevens, RG, Hublin, C, Partinen, M, Koskenvuo, M, Kaprio, J 2005, 'Sleep duration and breast cancer: A prospective cohort study', Epidemiology, vol 16, pp. 115-115.

2006 Bachman, P, Kim, J, Yee-Bradbury, CM, Therman, S, Manninen, M, Lönnqvist, J, Kaprio, J, Näätänen, R, Cannon, TD 2006, 'Two tests of neural efficiency in schizophrenia patients performing a working memory task: [Poster Session Abstract]', Psychophysiology, vol 43, no. Supplement s1, pp. S21-S22.

Järvenpää, T, Rinne, JO, Koskenvuo, M, Raiha, I, Kaprio, J 2006, 'Binge drinking and dementia - The authors respond', Epidemiology, vol 17, pp. 484-485.

Kaprio, J 2006, 'Lahjakkuuden monet ulottuvuudet', Duodecim, vol 122, no. 23, pp. 2871-2877.

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Kaprio, J 2006, 'Genetic epidemiology of cannabis use, abuse and dependence: a comment on Agrawal and Lynskey (2006) : [comment]', Addiction, vol 101, no. 6, pp. 779-780.

Kontula, K 2006, 'Suomalainen Lääkäriseura Duodecim: 125 vuotta suomalaisten terveyden hyväksi : [Pääkirjoitus]', Duodecim, vol 122, pp. 4-6.

Pakkala, S, Kontula, K 2006, 'Keski-ikäisen naisen raju hemolyyttinen sairaus: [Kliinis-patologinen kokousselostus]', Duodecim, vol 122, pp. 1781-1785.

Peltonen, JO, Tuulio-Henriksson, A, Loukola, A, Ekelund, J, Paunio, T, Hennah, W, Varilo, T, Suvisaari, J, Partonen, T, Lönnqvist, J, Peltonen, L 2006, 'Alleles of reelin gene show association with working memory in Finnish schizophrenia famillies: [Abstract, XIV World Congress on Psychiatric Genetics, 28.10-1.11.2006, Cagliari, Italy]', American journal of medical genetics. Part B, Neuropsychiatric genetics, vol 141B, no. 7, pp. 705-705.

Taskinen, M 2006, 'Should we dismiss fibrates for the treatment of diabetic dyslipidaemia?: [editorial]', Nutrition, Metabolism and Cardiovascular Diseases, vol 16, pp. 509-512.

Verkasalo, PK, Lillberg, K, Stevens, RG, Hublin, C, Partinen, M, Koskenvuo, M, Kaprio, J 2006, 'Sleep duration, melatonin, and breast cancer: Compliment and complement - Response', Cancer Research, vol 66, no. 7, pp. 3954-3954.

2007 Groop, LC, Lyssenko, V, Tuomi, T 2007, 'Tyypin 2 diabeteksen genetiikka selviämässä - Taustalla monen heikkotehoisen alttiusgeenin yhteispeli', Duodecim, vol 123, no. 12, pp. 1449-1455.

Kere, J 2007, 'Miten Suomessa kerättyjä DNA- ja kudosnäytteitä voidaan hyödyntää?: [pääkirjoitus]', Duodecim, vol 123, no. 8, pp. 864-865.

Raevuori, A, Keski-Rahkonen, A 2007, 'Miesten syömishäiriöt ja tyytymättömyys lihaksistoonsa: [katsaus]', Duodecim, vol 123, no. 13, pp. 1583-1589.

Ronkainen, P, Pöllänen, E, Törmäkangas, T, Tiainen, K, Kaprio, J, Rantanen, T, Sipilä, S, Kovanen, V 2007, 'Skeletal muscle properties in older women: effects of a functional polymorphism in COMT Gene : 2495 : Board #42 June 2 9:30 AM - 11:00 AM : [Free Communication/Poster]', Medicine and Science in Sports and Exercise, vol 39, no. Suppl, pp. S468.

Taskinen, M 2007, 'Is metabolic syndrome the main threat to human health in the twenty-first century?', Arteriosclerosis, Thrombosis, and Vascular Biology, vol 27, no. 11, pp. 2275.

Tuomi, T 2007, '“Sokerit koholla” – diagnoosi? ', Duodecim, vol 123, no. 12, pp. 1457-1463.

2008 Bilguvar, K, Yasuno, K, Niemelä, M, Ruigrok, YM, von and zu Fraunberg, M, van Duijn, CM, van den Berg, LH, Mane, S, Mason, CE, Choi, M, Gaal, E, Bayri, Y, Ronkainen, A, Laakso, A, Koivisto, T, Rinne, J, Öhman, J, Hernesniemi, J, Jääskeläinen, J, Palotie, A 2008, 'Susceptibility loci for intracranial aneurysm in European and Japanese populations: [letter]', Nature Genetics, vol 40 (2008) 12, pp. 1472-1477.

Lohi, H, Suhonen, E 2008, 'Geenitutkimuksella terveempi suomenajokoirakanta', Eläinlääkäri : Suomen eläinlääkärilehti, vol 114, no. 3, pp. 164-166.

Niemelä, M, Frösen, J, Hernesniemi, J, Dashti, R, Palotie, A 2008, 'Molecular pathology of aneurysms: [editorial]', Surgical Neurology, vol 70, pp. 36-38.

Salmela, E, Lappalainen, T, Fransson, I, Andersen, PM, Dahlman-Wright, K, Fiebig, A, Sistonen, P, Savontaus, M, Schreiber, S, Kere, J, Lahermo, P 2008, 'Suomalaisten geneettiset erot muihin eurooppalaisiin verrattuna suuret: [in press PLoS ONE, referaatti]', Duodecim, vol 124, no. 22, pp. 2584.

Yuille, M, van Ommen, G, Bréchot, C, Cambon-Thomsen, A, Dagher, G, Landegren, U, Litton, J, Pasterk, M, Palotie, L, Taussig, M, Wichmann, H, Zatloukal, K 2008, 'Biobanking for Europé', Briefings in Bioinformatics.

2009 Hemilä, H, Kaprio, J 2009, 'Vitamin E supplementation may transiently increase tuberculosis risk in males who smoke heavily and have high dietary vitamin C intake - reply by Hemila', British Journal of Nutrition, vol 101, pp. 146-147.

Kaprio, J 2009, 'Commentary on Chen et al. (2009): Gene-environment interactions in nicotine dependence', Addiction, vol 104, pp. 1741-1742.

Lahti, T, Sihvola, E, Partonen, T 2009, 'Suojaako oikeaan aikaan aloitettu lääkehoito ADHD-potilaita päihdehäiriöiltä?', Erikoislääkäri, vol 19, no. 1, pp. 11-13.

Lohi, H, Nicholas, FW 2009, 'Unlocking the genetic make-up of canine hip dysplasia: we can work it out', Veterinary Journal, vol 181, no. 2, pp. 77-78.

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Mänty, M, Heinonen, A, Viljanen, A, Pajala, S, Koskenvuo, M, Kaprio, J, Rantanen, T 2009, 'Outdoor and indoor falls as predictors of mobility limitation in older women', Age and Ageing, vol 38, no. 6, pp. 757-761.

Paunio, T, Korhonen, T, Hublin, C, Partinen, M, Kivimäki, M, Koskenvuo, M, Kaprio, J 2009, 'Unen heikko laatu vähentää tyytyväisyyttä elämään: [In press]', Duodecim, vol 125, no. 3, pp. 305.

Raevuori, A, Niemelä, S, Keski-Rahkonen, A, Sourander, A 2009, 'Syömishäiriöiden varhaiset riskitekijät', Duodecim, vol 125, no. 1, pp. 38-45.

Saarni, SE, Anttila, H, Saarni, SI, Ikonen, T, Malmivaara, A 2009, 'Lihavuusleikkauksen vaikutukset psyykkiseen ja sosiaaliseen hyvinvointiin', Duodecim, vol 125, no. 20, pp. 2287-2294.

Tuulio-Henriksson, A, Dick, DM, Vuoksimaa, E, Suvisaari, J, Viken, RJ, Kaprio, J, Rose, RJ 2009, 'Cognitive functioning and alcohol dependence symptoms in young adulthood: Investigating the association in finnish twins: [Behavior Genetics Association 39th Annual Meeting Abstract]', Behavior Genetics, vol 39, no. 6, pp. 666-666.

2010 Ebeling, F, Rahkonen, L, Saastamoinen, K, Matikainen, N, Laitinen, K 2010, 'Oksentelevan odottajan sytopeniat: [vinkistä vihiä + vastaus]', Duodecim, vol 126, no. 6, pp. 667, 669.

Hellquist, A, Jarvinen, TM, Koskenmies, S, Zucchelli, M, Orsmark-Pietras, C, Berglind, L, Panelius, J, Hasan, T, Julkunen, H, D'Amato, M, Saarialho-Kere, U, Kere, J 2010, 'Lack of Interaction Between Systemic Lupus Erythematosus-associated Polymorphisms in TYK2 and IRF5 Reply', Journal of Rheumatology, vol 37, no. 3, pp. 678-678.

Howard, BV, Taskinen, M 2010, 'CVD in women INTRODUCTION', Nutrition, Metabolism and Cardiovascular Diseases, vol 20, no. 6, pp. 377-378.

Keski-Rahkonen, A 2010, 'Uhanalainen kliininen tutkija', Duodecim, vol 126, no. 18, pp. 2207-8.

Keski-Rahkonen, A 2010, 'Syömishäiriöt - ohimenevä kiusa vai ikuinen riesa?', Duodecim, vol 126, no. 18, pp. 2209-14.

Paronen, J, Tuomi, T 2010, 'Kummalliset sokeriarvot', Duodecim, vol 126, no. 7, pp. 829-831.

Partonen, T, Treutlein, J, Alpman, A, Frank, J, Johansson, C, Depner, M, Aron, L, Rietschel, M, Wellek, S, Soronen, P, Paunio, T, Koch, A, Chen, P, Lathrop, M, Adolfsson, R, Persson, M, Kasper, S, Schalling, M, Peltonen, L, Schumann, G 2010, 'Three circadian clock genes Per2, Arntl and Npas2 contribute to winter depression (vol 39, pg 229, 2007)', Annals of Internal Medicine, vol 42, no. 7, pp. 555-555.

Sihvola, E, Marttunen, M, Kaprio, J 2010, 'Masennus ennakoi nuoren päihdeongelmaa', Duodecim, vol 126, no. 11, pp. 1245-1246.

B2 Contribution to book/other compilations (non-refereed)

2005 Hovatta, I, Saarela, J 2005, 'Affymetrix GeneChip system', in J Tuimala, M Laine (eds), DNA Microarray Data Analysis, CSC - Scientific Computing Ltd., pp. 25-31.

2007 Nevalainen, E, Paavilainen, V, Lappalainen, P 2007, 'Twinfilin family of actin monomer-binding proteins', in P Lappalainen (ed.), Actin Monomer Binding Proteins, Landes Bioscience, New York, NY, pp. 53-60.

2008 Palotie, L 2008, 'Consequences of the Genome Project for Understanding Development', Consequences of the Genome Project for Understanding Development, vol. 2008, Inborn Errors of Development, vol. 2008, Oxford University Press, pp. 49-54.

Silander, K, Saarela, J 2008, 'Whole genome amplification with Phi29 DNA polymerase to enable genetic or genomic analysis of samples of low DNA yield', Genomics Protocols, Methods in Molecular Biology, vol. 2008/439, Genomics Protocols, Methods in Molecular Biology, vol. 2008/439, Springer, pp. 1-18.

2009 Anttila, H, Saarni, SE, Saarni, SI, Isojärvi, J, Ikonen, T, Malmivaara, A 2009, 'Lihavuuden ja lihavuusleikkausten merkitys ja vaikutukset potilaiden kuvaamina', in TSI.[A (ed.), Sairaalloisen lihavuuden leikkaushoito, Raportti / Terveyden ja hyvinvoinnin laitos, Terveyden ja hyvinvoinnin laitos, [Helsinki], pp. 125-147.

Saarni, SI, Anttila, H, Saarni, SE, Mustajoki, P, Koivukangas, V, Ikonen, T, Malmivaara, A 2009, 'Sairaalloisen lihavuuden leikkaushoito: eettisiä näkökohtia', in TSI.[A (ed.), Sairaalloisen lihavuuden leikkaushoito, Raportti / Terveyden ja hyvinvoinnin laitos, Terveyden ja hyvinvoinnin laitos, [Helsinki], pp. 148-161.

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B3 Unrefereed article in conference proceedings

2005 Kaprio, J, Broms, UH, Shiffman, S, Madden, PAF 2005, A study of nicotine dependence in twins based on the NDSS scale,, Nicotine & Tobacco Research 7 OXFORD UNIVERSITY PRESS.

2006 Kaprio, J, Dick, D, Huizink, A, Rose, RJ 2006, Cannabis use among Finnish adolescents and young adults,, Behavior Genetics 36 SPRINGER NEW YORK LLC.

2007 Agrawal, A, Heath, AC, Wang, JC, Morrison, A, Saccone, SF, Pergadia, ML, Dick, DM, Montgomery, GW, Rice, JF, Kaprio, J, Todd, RD, Martin, NG, Madden, PAF 2007, Alcohol consumption and the cholinergic muscarinic receptor (CHRM2) in the nicotine addiction genetics project,, Alcoholism: Clinical and Experimental Research 31 WILEY-BLACKWELL PUBLISHING, INC..

Anttila, V, Artto, V, Farkkila, M, Kallela, M, Martin, N, Nyholt, D, Palotie, A, Sarahonka, A, Terwilliger, J, Vepsalainen, S, Wessman, M 2007, The first genome-wide interpopulation study of migraine families points to a locus on chromosome 10q22,, Cephalalgia 27 WILEY-BLACKWELL PUBLISHING LTD..

C1 Published scientific monograph

2005 Varilo, T, Palotie, L 2005, Population selection in complex disease gene mapping. In: Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics (Ed. M. J. Dunn, L. B. Jorde, P. F. R. Little, S. Subramaniam), 465-478., John Wiley & Sons.

C2 Edited book, compilation, conference proceeding or special issue of journal

2005 Saharinen, J, Ellonen, P, Saarela, J, Palotie, L 2005, Multiplexed SNP genotyping using allele specific primer extension on microarrays: In: DNA Microarrays, BIOS Advanced Methods , vol. 2005, Taylor & Francis.

2006 Pulkkinen, L, Kaprio, J, Rose, RJ (eds) 2006, Socioemotional development and health from adolescence to adulthood, Cambridge studies on child and adolescent health, Cambridge University Press, Cambridge.

2008 Ollila, H, Broms, U, Laatikainen, T, Patja, K (eds) 2008, Nuoret ja tupakoinnin lopettaminen: tutkimuksesta käytännön tukeen, Kansanterveyslaitoksen julkaisujaB, no. 2008, 37, Kansanterveyslaitos, Helsinki.

2009 Ikonen, TS, Anttila, H, Gylling, H, Isojärvi, J, Koivukangas, V, Kumpulainen, T, Mustajoki, P, Mäklin, S, Saarni, SI, Saarni, SE, Sintonen, H, Victorzon, M, Malmivaara, A (eds) 2009, Sairaalloisen lihavuuden leikkaushoito, Raportti / Terveyden ja hyvinvoinnin laitos, no. 16/2009, Terveyden ja hyvinvoinnin laitos, [Helsinki].

D1 Article in professional journal

2005 Lohi, HT 2005, 'Koiran epilepsiageeni löydettiin suomalaisvoimin', Eläinlääkäri : Suomen eläinlääkärilehti, vol 2005/2, pp. 90-91.

2006 Lohi, HT 2006, 'Lyhyesti: uutta suomalaista koiragenetiikkaa', Eläinlääkäri : Suomen eläinlääkärilehti, vol 2006/3, pp. 143.

2007 Kallio, S, Saarela, J, Palotie, L 2007, 'Multippeliskleroosi – geenitutkimus apuna taudin biologisen palapelin kokoamisessa', Duodecim, vol 2007/123, no. 18, pp. 2217-25.

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2010 Kere, J, Meri, S, Suomalainen Wartiovaara, A 2010, 'Molekyyligenetiikan huima neljännesvuosisata (Two decades of molecular genetics)', Duodecim, vol 126, no. 19, pp. 2297-2299.

Kere, J, Ripatti, SO, Perola, M 2010, 'Monitekijäisten tautien genetiikka', Duodecim, vol 126, no. 19, pp. 2305-2310.

Myllykangas, LT, Paunio, T, Lundin, JE, Marjamaa, A, Silander, K, Pennanen, P, Aarnio, M, Oksanen, MK, Dias, J, Pesonen, S, Hemminki, AE 2010, 'Ulkomaiset lääkärit, hammaslääkärit ja tieteelliset jatko-opiskelijat Suomessa', Suomen lääkärilehti , vol 41, pp. 3309-3314.

Ollila , H, Broms, UH, Kaprio, J, Laatikainen, T, Patja, K 2010, 'Nuorten tupakkariippuvuuden arviointi ja hoito terveydenhuollossa', Duodecim, vol 126, no. 11, pp. 1269-1278.

Sihvola, E 2010, 'Varhaisnuoruuden masennus altistaa päihteiden käytölle', Suomen lääkärilehti , vol 65, no. 1-2, pp. 63-64.

Silventoinen, K, Kaprio, J 2010, 'Liikunta auttaa vähentämään geneettisen alttiuden vaikutusta lihavuuteen', Duodecim, vol 126, no. 9, pp. 1031-1036.

D2 Article in professional hand or guide book or in a professional data system, or text book material

2009 Lindsberg, P, Kallela, KMJ 2009, 'Tajuton potilas: Comatose patient', in I Kunnamo (ed.), Lääkärin käsikirja. Physician's Desk Reference Book., Duodecim.

2010 Tiira, KA 2010, 'Koiran käyttäytyminen ja hyvinvointi', in M Saastamoinen, H Teräväinen (eds), Koiran ruokinta ja hoito, into&taito, no. 1, ProAgria Keskusten Liiton julkaisuja, no. 1098, ProAgria Keskusten liitto, Hämeenlinna, pp. 95-106.

D3 Article in professional conference proceedings

2008 Lahtinen, AM, Lehtonen, A, Kaartinen, M, Toivonen, L, Swan, H, Widen, E, Lehtonen, E, Lehto, V, Kontula, K 2008, Clinicopathological correlates in Finnish ARVD patients,, European Journal of Cell Biology 87 URBAN UND FISCHER VERLAG.

Lahtinen, AM, Marjamaa, A, Kaartinen, M, Toivonen, L, Swan, H, Widen, E, Lehtonen, E, Lehto, V, Kontula, K 2008, Population-specific spectrum of desmosomal mutations in arrhythmogenic right ventricular cardiomyopathy,, European Journal of Cell Biology 87 URBAN UND FISCHER VERLAG.

E1 Popular article, newspaper article

2005 Lohi, HT 2005, 'Geenivirhe altistaa koiran epilepsialle', Kaleva.

Lohi, HT 2005, 'Kanadassa työskentelevä suomalaistutkija löysi koiran epilepsiageenin', Vapaa sana., vol 2005/2.

Rantanen, T, Tiainen, K, Sipila, S, Kauppinen, M, Koskenvuo, M, Kaprio, J 2005, 'Genetic and environmental effects on the change in leg extension power among older women: A three-year follow-up', Gerontologist, vol 45, pp. 65-65.

Viken, RJ, Rose, RJ, Kaprio, J, Koskenvuo, M 2005, 'Genetic and environmental transmission of masculinity femininity: Parent-offspring models', Behavior Genetics, vol 35, pp. 824-824.

2006 Saarni, SI, Korhonen, T, Sailas, ES 2006, 'Voiko potilaiden terveyskäyttäytymiseen vaikuttaa? Elämäntapamuutokset ja motivoiva haastattelu', Therapia., vol 2, pp. 28-32.

2007 Keskitalo, K, Knaapila, A 2007, 'Makean mieltymykset ovat osittain periytyviä', Kansanterveys : Kansanterveyslaitoksen tiedotuslehti., vol 2007, no. 5 - 6, pp. 12 - 13.

Keskitalo, K 2007, 'Mieltymys makeaan makuun', Perspektiivi aikakauslehti sokerista ja ravitsemuksesta. , vol 7, no. 10, pp. 14-15.

Saavalainen, P, Kaukinen, K, de Kauwe, A, Kauwe, A 2007, 'Keliakiarokote ja uutta diagnostiikkaa', Keliakialehti, vol 2007, no. 4, pp. 8-10.

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2008 Korhonen, T, Broms, UH, Rose, R, Kaprio, J 2008, 'Twin and Family Research on Smoking Behavior and Nicotine Dependence: The Finnish Chapter', SRNT Newsletter, vol 14, pp. 1.

Lohi, HT 2008, 'Läpimurto tryffelikuonojen epilepsiatutkimuksessa', Lagotto, vol 2/2008, pp. 9-11.

2009 Koskinen, L 2009, 'Keliakian perintötekijöitä tutkitaan ahkerasti: keliakian alttiusgeeneistä on vielä suuri osa löytymättä', Keliakialehti, no. 5, pp. 6-7.

Lohi, HT 2009, 'The geneticist's best friend', Helsinki University Bulletin, no. 4/2009.

E1 Popular contribution to book/other compilations

2010 Kontula, K 2010, 'Yliopiston ja yliopistosairaalan yhteistyö', in LA Laitinen (ed.) , HUS siunatkoon, Duodecim, pp. 80-90.

E2 Popular monograph

2008 Kere, J, Finer, D 2008, Dyslexi: stavfel i generna, Karolinska Institutet University Press, Stockholm.

2010 Keski-Rahkonen, A, Lindholm, C, Ruohonen, J, Tapola-Haapala, M 2010, Tutkimusmatkoja äitiyteen, PerSona, Kustannus Oy Duodecim.

H1 Patents

2005 Toivonen, H, Onkamo, P, Vasko, K, Ollikainen, VV, Sevon, P, Mannila, H, Kere, J May. 20 2010 , Method for gene mapping from chromosome and phenotype data, 6909971.

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RC-SPECIFIC TUHAT COMPILATIONS OF OTHER SCIENTIFIC ACTIVITIES 2005-2010

1 Analysis of activities 2005-2010 - Associated person is one of Jaakko Kaprio , Leonie-Helen Bogl , Ulla Heidi Broms , Anna Keski-Rahkonen , Tellervo Korhonen , Hanna-Reetta Lajunen , hanna-reetta. Antti Latvala , Anu-Maria Loukola , Linda Marina Mustelin , Miina Ollikainen , Alfredo Ortega-Alonso , Kirsi Hannele Pietiläinen , Anu Hannemari Raevuori , Suoma Eeva Matilda Saarni , Elina Sihvola , Kaisu Keskitalo ,

Juha Kere , Outi Kaarina Elomaa , , Katariina Sara Eriikka Hannula-Jouppi , , Tiina Järvinen , Nina Johanna Kaminen-Ahola, Satu Massinen ,

Ville Pertti Pulkkinen , , Anna Rautanen , Elina Salmela , , Lilli Sundman , Mari Hannele Tervaniemi , Satu

Johanna Wedenoja , Kimmo Kontula , Kati Donner , , Timo Hiltunen , Annukka Lahtinen , Jukka Tapani Lehtonen , Annukka Marjamaa ,

Kirsi Riitta Sinikka Paukku , Timo Suonsyrjä, Hannes Tapani Lohi , Saija Ahonen , Marjo Kristiina Hytönen , , Päivi Jokinen , Lotta Koskinen ,

, Kaisa Kyöstilä , Elisa Nevalainen , Eija Seppälä , Katriina Annikki Tiira , , Aarno Palotie , Verneri Anttila , , Kaarlo Mikko Juhani Kallela , Mikko Sakari Muona , Olli

Pietiläinen , Maija Wessman , Leena Palotie , William Hennah , Marine Largeau , Jussi Naukkarinen , Kaisa Silander ,

Jarkko Matias Soronen , Teppo Varilo , Juho Wedenoja , Samuli Olli Ripatti , Johannes Kettunen , Pirkka-Pekka Laurila , Karola Hannele Rehnström ,

Mari Rossi , Ida Liisa Surakka , Janna Saarela , Eveliina Jakkula , Virpi Maria Leppä , Anna-Maija Kristiina Sulonen , Päivi Marjaana Saavalainen , Elisabet Einarsdottir , Katja Löytynoja , Amarjit Parmar ,

Marja-Riitta Taskinen , Marit Anneli Graner , Antti Hakkarainen, Anne Sinikka Hiukka , Aarne Juhani Kahri , , Nina Lundbom , Niina Hanna Talvikki Matikainen , Emmi Rautaheimo , Olga Rimpilä , Sanni Söderlund ,

, Helena Tikkanen , Tiinamaija Tuomi , Mette Korre Andersen , Bo Isomaa , , Mikko Lehtovirta , Brita Kristina Liljeström , Virve Lundgren , , Carola Saloranta , Satu Vehkavaara ,

, Elisabeth Ingrid Maria Widen , Diana Laura Cousminer , Jaakko Leinonen ,

Activity type Count

Supervisor or co-supervisor of doctoral thesis 107

Prizes and awards 41

Editor of research journal 64

Peer review of manuscripts 88

Assessment of candidates for academic posts 12

Membership or other role in review committee 12

Membership or other role in research network 13

Membership or other role in national/international committee, council, board 169

Membership or other role in public Finnish or international organization 39

Membership or other role of body in private company/organisation 8

Participation in interview for written media 59

Participation in radio programme 15

Participation in TV programme 18

CompDisGen/Kaprio

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Activity type Count

Participation in interview for web based media 3

CompDisGen/Kaprio

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2 Listing of activities 2005-2010

Supervisor or co-supervisor of doctoral thesis Jaakko Kaprio , Supervisor, Doctoral theses: Tuula Kieseppä, Jaakko Kaprio, 1997 2005, Finland

Supervisor, Doctoral theses: Harri Hemilä, Jaakko Kaprio, 1998 2006, Finland

Supervisor, Doctoral theses: Annina Ropponen, Jaakko Kaprio, 1999 2006, Finland

Supervisor, Doctoral theses: Bidel Siamak, Jaakko Kaprio, 2000 2008, Finland

Supervisor, Doctoral theses: Varpu Penninkilampi-Kerola, Jaakko Kaprio, 2000 2006, Finland

Supervisor, Doctoral theses: Marja Heinonen-Guzjev, Jaakko Kaprio, 2001 2008, Finland

Supervisor, Doctoral theses: Suoma Saarni, Jaakko Kaprio, 2001 2008, Finland

Supervisor, Doctoral theses: Ulla Broms, Jaakko Kaprio, 2001 2008, Finland

Supervisor, Doctoral theses: Anu Raevuori, Jaakko Kaprio, 2002 2009, Finland

Supervisor, Doctoral theses: Eero Vuoksimaa, Jaakko Kaprio, 2003 2010, Finland

Supervisor, Doctoral theses: Elina Sihvola, Jaakko Kaprio, 2003 2010, Finland

Supervisor, Doctoral theses: Hanna-Reetta Lajunen, Jaakko Kaprio, 2003 2010, Finland

Supervisor, Doctoral theses: Aki Rogel, Jaakko Kaprio, 2004 …, Finland

Supervisor, Doctoral theses: Leonie-Helen Bogl, Jaakko Kaprio, 2004 …, Finland

Supervision of Doctoral Theses: Marja-Liisa Kinnunen, Jaakko Kaprio, 2005, Finland

Supervision of Doctoral Theses: Heli Bäckmand, Jaakko Kaprio, 2006, Finland

Supervision of Doctoral Thesis: Anne Viljanen, Jaakko Kaprio, 2006, Finland

Supervision of Doctoral Thesis: Kristiina Tiainen, Jaakko Kaprio, 2006, Finland

Supervision, mentoring and examination of Doctoral Thesis: Katja Waller, Jaakko Kaprio, 01.01.2006 31.12.2006, Finland

Supervision, mentoring of Doctoral Thesis: Satu Pajala, Jaakko Kaprio, 01.01.2006 31.12.2006, Finland

Supervisor, Doctoral theses: Juha Hämäläinen, Jaakko Kaprio, 2006 …, Finland

Supervisor, Doctoral theses: Jyrki Varjonen, Jaakko Kaprio, 2006 …, Finland

Supervisor, Doctoral theses: Linda Mustelin, Jaakko Kaprio, 2006 …, Finland

Supervisor, Doctoral theses: Maria Hukkinen, Jaakko Kaprio, 2006 …, Finland

Anna Keski-Rahkonen , Supervisor, doctoral theses: Anu Raevuori, Anna Keski-Rahkonen, 2001 2008, Finland

Tellervo Korhonen , Supervisor, Tellervo Korhonen, 2008 …, Finland

Supervision, Tellervo Korhonen, 2009 …, Finland

Juha Kere , Supervisor of Doctoral Thesis project: Minna Kujala-Myllynen, Juha Kere, 1998 2005, Finland

Supervisor of Doctoral Thesis project: Johanna Vendelin, Juha Kere, 2000 2007, Finland

Supervisor of Doctoral Thesis project: Nina Ahola, Juha Kere, 2000 2007

Supervisor of Doctoral Thesis project: Anna Rautanen, Juha Kere, 2001 2007, Finland

Supervisor of Doctoral Thesis project: Erik Melén, Juha Kere, 2001 2006, Sweden

Supervisor of Doctoral Thesis project: Heidi Anthoni, Juha Kere, 2001 2007, Sweden

Supervisor of Doctoral Thesis project: Ville Pulkkinen, Juha Kere, 2001 2006

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Supervisor of Doctoral Thesis project: Inkeri Tiala, Juha Kere, 2002 2009, Finland

Supervisor of Doctoral Thesis project: Tuuli Lappalainen, Juha Kere, 2002 2009, Finland

Supervisor of Doctoral Thesis project: Anna Hellquist, Juha Kere, 2003 2009, Sweden

Supervisor of Doctoral Thesis project: Hanna Peterson, Juha Kere, 2003 2010, Sweden

Supervisor of Doctoral Thesis project: Tuula Siljander, Juha Kere, 2003 2009, Finland

Supervisor of Doctoral Thesis project: Ulf Hannelius, Juha Kere, 2003 2008, Sweden

Supervisor of Doctoral Thesis project: Sara Bruce, Juha Kere, 2004 2009, Sweden

Supervisor of Doctoral Thesis project: Lotta Koskinen, Juha Kere, 2005 2009, Finland

Supervisor of Doctoral Thesis project: Tiina Järvinen, Juha Kere, 2005 2010, Finland

Outi Kaarina Elomaa , , Väitöskirjan ohjaus, Outi Kaarina Elomaa, 2009 …

Katariina Sara Eriikka Hannula-Jouppi , , Supervision of doctoral thesis, Katariina Sara Eriikka Hannula-Jouppi, 01.01.2005 31.12.2005, Sweden

Väitöskirja, Katariina Sara Eriikka Hannula-Jouppi, 01.2005 02.2009

Kimmo Kontula , Supervisor of doctoral thesis: Heidi Fodstad, Kimmo Kontula, 2005, Finland

Supervisor of doctoral thesis: Kaisa Valli-Jaakkola, Kimmo Kontula, 2007, Finland

Supervisor of doctoral thesis: Maarit Lappalainen, Kimmo Kontula, 2008, Finland

Supervisor of doctoral thesis: Annukka Marjamaa, Kimmo Kontula, 2009

Supervisor of doctoral thesis: Tuula Hannila-Handelberg, Kimmo Kontula, 2010, Finland

Hannes Tapani Lohi , Supervisor of Doctoral Thesis: Päivi Jokinen, Hannes Tapani Lohi, 2006 2011, Finland

Supervisor of Doctoral Thesis: Alina Niskanen, Hannes Tapani Lohi, 2008 …, Finland

Supervisor of Doctoral Thesis: Heli Venhoranta, Hannes Tapani Lohi, 2008 …, Finland

Supervisor of Doctoral Thesis: Kaisa Kyöstilä, Hannes Tapani Lohi, 2008 …, Finland

Supervisor of Doctoral Thesis: Marjo Hytönen, Hannes Tapani Lohi, 2008 …, Finland

Supervisor of Doctoral Thesis: Riitta Seppänen, Hannes Tapani Lohi, 2008 …, Finland

Supervisor of Doctoral Thesis: Saija Ahonen, Hannes Tapani Lohi, 2008 …, Finland

Supervisor of doctoral thesis: Alina Niskanen, Hannes Tapani Lohi, 2008, Finland

Supervisor of Doctoral Thesis: Vivi Deckwirth, Hannes Tapani Lohi, 2009 …, Finland

Supervisor of Doctoral Thesis: Osmo Hakosalo, Hannes Tapani Lohi, 2010 …, Finland

Aarno Palotie , Supervisor of doctoral dissertation: Tiina Heliö, Aarno Palotie, 2005

Supervisor of doctoral thesis: Danny Chan, Aarno Palotie, 2005, Hong Kong

Supervisor of doctoral thesis: Denis Bronnikov, Aarno Palotie, 28.06.2005, United States

Supervisor of doctoral thesis: Lisa-Lanyi Mee, Aarno Palotie, 27.06.2005, United States

Supervisor of doctoral thesis: Mari Kaunisto, Aarno Palotie, 11.2005, Finland

Supervisor of doctoral thesis:Gregory Oswell, Aarno Palotie, 2005, United States

Supervisor of doctoral thesis:Harri Visapää, Aarno Palotie, 07.06.2006, Finland

Co-supervisor of doctoral thesis: Päivi Tikka-Kleemola, Aarno Palotie, 15.06.2009, Finland

Supervisor of doctoral thesis: Verneri Anttila, Aarno Palotie, 15.06.2010, Finland

CompDisGen/Kaprio

5



Leena Palotie , Supervision of Doctoral Thesis: Elina Suviolahti, Leena Palotie, 2005 …

Supervision of Doctoral Thesis: Jenny Ekholm, Leena Palotie, 2005

Supervision of Doctoral Thesis: Lisa Lanyi-Mee, Leena Palotie, 2005, United States

Supervision of Doctoral Thesis: Nabil Enattah, Leena Palotie, 2005 …

Supervision of Doctoral Thesis: Tero Ylisaukko-oja, Leena Palotie, 2005 …

Supervision of Doctoral Thesis: William Hennah, Leena Palotie, 2005 …

Supervsion of Doctoral Thesis, Leena Palotie, 01.01.2005 31.12.2005, United States

Supervision of Doctoral Thesis: Mira Kyttälä, Leena Palotie, 2006

Supervisor of doctoral thesis: Niklas Pakkasjärvi, Leena Palotie, 20.01.2006, Finland

Supervision of Doctoral Thesis: Anna Kiialainen, Leena Palotie, 2007

Supervision of Doctoral Thesis: Joni Turunen, Leena Palotie, 2007

Supervision of Doctoral Thesis: Kirsi Auro, Leena Palotie, 2007

Supervision of Doctoral Thesis: Jussi Naukkarinen, Leena Palotie, 2008

Supervision of Doctoral Thesis: Kati Kristiansson, Leena Palotie, 2008

Supervision of Doctoral Thesis: Sampo Sammalisto, Leena Palotie, 2008

Supervision of Doctoral Thesis: Karola Rehnström, Leena Palotie, 2009

Supervision of Doctoral Thesis: Suvi Kallio, Leena Palotie, 2009

Supervision of Doctoral Thesis: Helena Kilpinen, Leena Palotie, 2010

Supervision of Doctoral Thesis: Johannes Kettunen, Leena Palotie, 2010

Supervision of Doctoral Thesis: Juho Wedenoja, Leena Palotie, 2010

Supervision of Doctoral Thesis: Outi Marika Palo, Leena Palotie, 2010

William Hennah , The DISC1 Pathway in the Genetic Etiology of Schizophrenia, William Hennah, 2010, Finland

Janna Saarela , Supervisor of the PhD thesis: Suvi kallio, Janna Saarela, 26.06.2009, Finland

Päivi Marjaana Saavalainen , Supervision of a PhD dissertation of Katri Haimila, Päivi Marjaana Saavalainen, 01.01.2002 24.04.2009, Finland

Supervision of a PhD dissertation of Lotta Koskinen, Päivi Marjaana Saavalainen, 01.01.2005 25.09.2009, Finland

Elisabet Einarsdottir , Genetics of celiac disease, Elisabet Einarsdottir, 2009 …, Finland

Marja-Riitta Taskinen , Supervision of Doctoral thesis, Marja-Riitta Taskinen, 18.05.2007, Finland

Supervision of Doctoral thesis, Marja-Riitta Taskinen, 09.10.2009, Finland

Supervision of doctoral thesis, Marja-Riitta Taskinen, 18.12.2010, Finland

Tiinamaija Tuomi , Supervisor of doctoral thesis: Åsa Linda Carlsson, Tiinamaija Tuomi, 1995 …, Finland

Supervisor of doctoral thesis: Brita Liljeström, Tiinamaija Tuomi, 2003 …, Finland

Supervisor of Advanced Studies: Elina Honkanen, Tiinamaija Tuomi, 2005, Finland

Supervisor of Advanced Studies: Hanna Koskela, Tiinamaija Tuomi, 2006, Finland

Supervisor of Advanced Studies: Elisa Hietamäki, Tiinamaija Tuomi, 2008, Finland

CompDisGen/Kaprio

6



Supervisor of Advanced Studies: Sanna Alkio, Tiinamaija Tuomi, 2008, Finland

Supervisor of Advanced Studies: Linda Stoor, Tiinamaija Tuomi, 2010, Finland

Supervisor of doctoral thesis: Virve Lundgren, Tiinamaija Tuomi, 2010 …, Finland

Prizes and awards Jaakko Kaprio , Elected Epidemiologist of the Year by the Finnish Epidemiological Society, Jaakko Kaprio, 2005, Finland

Doctor of Medicine h.c., Jaakko Kaprio, 2006, Denmark

First Prize Paper Presentation at 2007 meeting, Jaakko Kaprio, 2007, United Kingdom

Young Neurosurgeon -competition 2nd prize, Jaakko Kaprio, 2007, Finland

Kappa Delta Award, Orthopedic Research Society, Jaakko Kaprio, 2008, United States

Knight 1st Class, Finnish Order of the White Rose, Jaakko Kaprio, 2008, Finland

Maud Kuistila memorial award for excellence in post-gradute teaching, Jaakko Kaprio, 2008, Finland

Juha Kere , Medix Prize 2005 for the best Finnish biomedical research paper published in 2004, Juha Kere, 2005, Finland

Distinguished Professor Award, Juha Kere, 2009, Sweden

Katariina Sara Eriikka Hannula-Jouppi , , The Endocrine Society and Pfizer, Inc. International Award for Excellence in Published Clinical Research in the Journal of Clinical Endocrinology and Metabolism 2009, Katariina Sara Eriikka Hannula-Jouppi, 2009 …, United States

Ville Pertti Pulkkinen , , Medix Prize 2005 for the best Finnish biomedical research article, Ville Pertti Pulkkinen, 21.10.2005

Kimmo Kontula , Invited Member of the Finnish Science Academy (Suomalainen Tiedeakatemia), Kimmo Kontula, 1994 …, Finland

Inspector of The Nation of the Southern Finland (ESO), University of Helsinki, Kimmo Kontula, 2000 2010

Matti Äyräpää Award, Duodecim Society, Kimmo Kontula, 2005, Finland

Honorary Member of The Duodecim Society of Helsinki District, Kimmo Kontula, 2007 …, Finland

Invited Member of the Finnish Society of Sciences and Letters (Suomen tiedeseura), Kimmo Kontula, 2007 …, Finland

The Order of the White Rose in Finland, Kimmo Kontula, 2007, Finland

Honorary Member of The Nation of the Southern Finland (ESO), University of Helsinki, Kimmo Kontula, 2010

Hypertension Specialist of the European Hypertension Society, Kimmo Kontula, 2010

Teaching Person of the Year, Faculty of Medicine, University of Helsinki, Kimmo Kontula, 2010, Finland

Hannes Tapani Lohi , Academy Research Fellowship, Hannes Tapani Lohi, 2006, Finland

Start up grant, Hannes Tapani Lohi, 2006, Finland

Academy Award for Scientific Courage, Hannes Tapani Lohi, 2007, Finland

Academy Award for scientific courage, Hannes Tapani Lohi, 01.01.2007, Finland

Award for Scientific Courage, Hannes Tapani Lohi, 2007, Finland

Canine epilepsy models, Hannes Tapani Lohi, 2008

Outstanding Young Person of Finland (TOYP), Hannes Tapani Lohi, 2009

Outstanding Young Person of the World finalist, Hannes Tapani Lohi, 2009

The Outstanding Young Person of Finland, Hannes Tapani Lohi, 2009, Finland

"Myötäkarvaan" honor recognition by the FinnExpo, Hannes Tapani Lohi, 2010, Finland

CompDisGen/Kaprio

7



The European Research Council (ERC) Starting Grant, Hannes Tapani Lohi, 2010

Elisa Nevalainen , Outstanding poster, Elisa Nevalainen, 25.09.2010, United States

Leena Palotie , Eric K. Fernströms Nordiska Priset, Leena Palotie, 2006, Sweden

European van Gysel Prize for Biomedical Research, Leena Palotie, 2006

Honorary Professor of the Faculty of Clinical Medicine, Cambridge University, Leena Palotie, 2008, United Kingdom

Academician of Science, Leena Palotie, 2009, Finland

The Carter Medal, Leena Palotie, 2009, United Kingdom

Janna Saarela , 2008 Kappa Delta Elisabeth Winston Lanier Award for Outstanding Orthopaedic Research, Janna Saarela, 05.03.2008, United States

Elisabet Einarsdottir , Finnish Coeliac Society research grant, Elisabet Einarsdottir, 2010

Marja-Riitta Taskinen , Esko A. Nikkilä Award, Marja-Riitta Taskinen, 01.01.2006 31.12.2011, Finland

Novartis Prize in Diabetes (Long-standing achievement), Marja-Riitta Taskinen, 01.01.2006 31.12.2011

Editor of research journal Jaakko Kaprio , Editorial Board Member: Psychiatric Genetics, Jaakko Kaprio, 01.01.1990 …, United States

Editor board Member: Finnish Journal of Social Medicine, Jaakko Kaprio, 01.01.1994 …, Finland

Associate Editor: Twin Research, Jaakko Kaprio, 01.01.1998 …, United Kingdom

Editorial Board Member: International Journal of Behavioral Medicine, Jaakko Kaprio, 01.01.1999 …, United States

Addiction Associate editor, Jaakko Kaprio, 2004 …

Associate Editor: Nicotine & Tobacco Research, Jaakko Kaprio, 01.01.2010 …, United Kingdom

Nicotine & Tobacco Research Associate editor, Jaakko Kaprio, 2010 …

Ulla Heidi Broms , Social Science & Medicine, Ulla Heidi Broms, 04.02.2005 31.12.2005, United States

European Journal of Cardiovascular Prevention and Rehabilitation, Ulla Heidi Broms, 17.05.2006 31.12.2006

Psychological Medicine, Ulla Heidi Broms, 19.10.2006 31.12.2006, United States

Tobacco Induced Diseases, Ulla Heidi Broms, 01.10.2008 31.12.2011, United States

Anna Keski-Rahkonen , European Eating Disorders Review, Anna Keski-Rahkonen, 01.01.2005 31.12.2005

European Journal of Clinical Nutrition, Anna Keski-Rahkonen, 01.01.2005 31.12.2005

Psychiatry Research, Anna Keski-Rahkonen, 01.01.2005 31.12.2005

Juha Kere , Member of editorial board: Human Genetics, Juha Kere, 2005 …

Member of editorial board: Human Molecular Genetics, Juha Kere, 2005 2010

Katariina Sara Eriikka Hannula-Jouppi , , Pediatric pulmonology, Katariina Sara Eriikka Hannula-Jouppi, 01.01.2005 31.12.2005

Kimmo Kontula , Member of the Editorial Board, Annals of Medicine, Kimmo Kontula, 1989 2010

CompDisGen/Kaprio

8



Timo Hiltunen , Biomarkers, Timo Hiltunen, 19.01.2009 30.01.2009, United Kingdom

Hypertension, Timo Hiltunen, 21.05.2009 02.06.2009, United States

Hypertension, Timo Hiltunen, 02.04.2009 18.04.2009, United States

Hannes Tapani Lohi , Journal of Epithelial Biology and Pharmacology, Hannes Tapani Lohi, 2008

Aarno Palotie , Member of Editorial Board: Scandinavian Journal of Clinical and Laboratory Investigations, Aarno Palotie, 2003 2008

Stroke, Aarno Palotie, 2004 2005, United States

American Journal of Human Genetics, Aarno Palotie, 2005, United States

American Journal of Medical genetics, Aarno Palotie, 2005, United States

Annals of Neurology, Aarno Palotie, 2005

European Journal of cancer, Aarno Palotie, 2005, United Kingdom

Human Genetics, Aarno Palotie, 2005

Human Molecular Genetics, Aarno Palotie, 2005

Journal of Molecular Diagnostics, Aarno Palotie, 2005

Molecular Psychiatry, Aarno Palotie, 2005

Neurogenetics, Aarno Palotie, 2005

Scandinavian Journal of Laboratory Investigations, Aarno Palotie, 2005, Norway

Stroke, Aarno Palotie, 2005, United States

Leena Palotie , Psychiatric Genetics, Leena Palotie, 1989 2010, United States

American Journal of Medical Genetics, Leena Palotie, 1992 2010, United States

Current Opinion in Genetics and Development, Leena Palotie, 2000 2010, United Kingdom

Gene Function & Disease, Leena Palotie, 2000 2010, United States

Molecular Genetics and Metabolism, Leena Palotie, 2000 2010, United States

Annals of Human Genetics, Leena Palotie, 2008 2010, United States

Genes, Leena Palotie, 2009 2010

Trends in Genetics, Leena Palotie, 2009 2010

Janna Saarela , Editor: Annals of Medicine, Janna Saarela, 01.01.2008 …

Marja-Riitta Taskinen , Arteriosclerosis, Thrombosis and Vascular Biology, Marja-Riitta Taskinen, 01.01.2005 31.12.2005, United States

Diabetes, Marja-Riitta Taskinen, 01.01.2005 31.12.2005, United States

Diabetes Care, Marja-Riitta Taskinen, 01.01.2005 31.12.2005, United States

Diabetologia, Marja-Riitta Taskinen, 01.01.2005 31.12.2005, Germany

J Clin Endocrinol Metab, Marja-Riitta Taskinen, 01.01.2005 31.12.2005, United States

NMCD, Marja-Riitta Taskinen, 01.01.2005 31.12.2005, Italy

Obesity Research, Marja-Riitta Taskinen, 01.01.2005 31.12.2005, United States

Arteriosclerosis, Thrombosis and Vascular Biology, Marja-Riitta Taskinen, 01.01.2006 31.12.2006, United States

Diabetes, Marja-Riitta Taskinen, 01.01.2006 31.12.2006, United States

CompDisGen/Kaprio

9



Diabetes Care, Marja-Riitta Taskinen, 01.01.2006 31.12.2006, United States

Diabetologia, Marja-Riitta Taskinen, 01.01.2006 31.12.2006

Journal of Lipid Research, Marja-Riitta Taskinen, 01.01.2006 31.12.2006, United States

The Journal of Clinical Endocrinology and Metabolism, Marja-Riitta Taskinen, 01.01.2006 31.12.2006, United States

Vascular Health and Risk Management, Marja-Riitta Taskinen, 01.01.2006 31.12.2006, New Zealand

Tiinamaija Tuomi , Reviewer for Diabetes, Tiinamaija Tuomi, 2000 …, United States

Reviewer of Diabetes Care, Tiinamaija Tuomi, 2000 …, United States

Reviewer of Diabetologia, Tiinamaija Tuomi, 2000 …

Editor of Duodecim, Tiinamaija Tuomi, 2003 …

Elisabeth Ingrid Maria Widen , European Journal of Human Genetics, Elisabeth Ingrid Maria Widen, 01.01.2006 31.12.2010

Journal of Clinical Investigation, Elisabeth Ingrid Maria Widen, 01.01.2006 31.12.2006

Peer review of manuscripts Jaakko Kaprio , Am J Clin Nutr, Jaakko Kaprio, 01.01.2005 31.12.2005

American Journal of Clinical Nutrition, Jaakko Kaprio, 01.01.2005 31.12.2005, United States

Arteriosclerosis, thrombosis and vascular biology, Jaakko Kaprio, 01.01.2005 31.12.2005, United States

Behavior Genetics, Jaakko Kaprio, 01.01.2005 31.12.2005, United States

European Journal of Human Genetics, Jaakko Kaprio, 01.01.2005 31.12.2005, United Kingdom

Health Psychology, Jaakko Kaprio, 01.01.2005 31.12.2005, United States

International Journal of Obesity, Jaakko Kaprio, 01.01.2005 31.12.2005, United Kingdom

Journal of Internal Medicine, Jaakko Kaprio, 01.01.2005 31.12.2005, Australia

Nicotine and Tobacco Research, Jaakko Kaprio, 01.01.2005 31.12.2005, United Kingdom

Referee for manuscript submitted to the Scandinavian Journal of Public Health, Jaakko Kaprio, 2005

Scand J Public Health, Jaakko Kaprio, 01.01.2005 31.12.2005, Sweden

Behavior Genetics, Jaakko Kaprio, 01.01.2006 31.12.2006, United States

Current Directions in Psychological Science, Jaakko Kaprio, 01.01.2006 31.12.2006, United States

Diabetologia, Jaakko Kaprio, 01.01.2006 31.12.2006, United States

European Journal of Human Genetics, Jaakko Kaprio, 01.01.2006 31.12.2006, United Kingdom

Health Psychology, Jaakko Kaprio, 01.01.2006 31.12.2006, United States

Journal of Sleep Research, Jaakko Kaprio, 01.01.2006 31.12.2006, United Kingdom

Journal of Sleep Research, Jaakko Kaprio, 01.01.2006 31.12.2006

Nicotine and Tobacco research, Jaakko Kaprio, 01.01.2006 31.12.2006, United Kingdom

Scandinavian Journal of Public Health, Jaakko Kaprio, 01.01.2006 31.12.2006, Sweden

Springer Publisher (review of article for Handbook of Behavior Genetics), Jaakko Kaprio, 01.01.2006 31.12.2006, United Kingdom

New England Journal of Medicine, Jaakko Kaprio, 01.01.2007 31.12.2007, United States

American Journal of Clinical Nutrition, Jaakko Kaprio, 01.01.2008 31.12.2008, United States

BMJ, Jaakko Kaprio, 01.01.2008 31.12.2008, United Kingdom

COPD, Jaakko Kaprio, 01.01.2008 31.12.2008

European Journal of Endocrinology, Jaakko Kaprio, 01.01.2008 31.12.2008, United Kingdom

CompDisGen/Kaprio

10



European Spine Journal, Jaakko Kaprio, 01.01.2008 31.12.2008, United Kingdom

International Journal of Obesity, Jaakko Kaprio, 01.01.2008 31.12.2008, United Kingdom

Kinesiologia Slovenica, Jaakko Kaprio, 01.01.2008 31.12.2008, Slovenia

Scandinavian Journal of Public Health, Jaakko Kaprio, 01.01.2008 31.12.2008, Sweden

Twin Research and Human Genetics, Jaakko Kaprio, 01.01.2008 31.12.2008, United Kingdom

Am J Psychiatry, Jaakko Kaprio, 2010

Ateriosclerosis, Thrombosis and Vascular Biology, Jaakko Kaprio, 2010

Psychological Medicine, Jaakko Kaprio, 2010

Referee for Diabetes and Metabolism, Jaakko Kaprio, 2010

Tellervo Korhonen , Health Education Research: Theory & Practice, Tellervo Korhonen, 2001 2005

Health Psychology, Tellervo Korhonen, 2001 2005

Addictive Behaviors, Tellervo Korhonen, 2005 2006

International Journal of Behavioral Medicine, Tellervo Korhonen, 2006 …

Addiction, Tellervo Korhonen, 2007 2009

BMC Public Health, Tellervo Korhonen, 2008 …

Archives of General Psychiatry, Tellervo Korhonen, 2009 …

Drug and Alcohol Dependence, Tellervo Korhonen, 2009 …

Journal of Adolescence, Tellervo Korhonen, 2009 …

Journal of Women's Health, Tellervo Korhonen, 2009 …

Annals of Medicine, Tellervo Korhonen, 2010 …

European Journal of Public Health, Tellervo Korhonen, 2010 …

Nicotine & Tobacco Research, Tellervo Korhonen, 2010 …

Katariina Sara Eriikka Hannula-Jouppi , , GeneReviews Gentic Disease Online Reviews, Katariina Sara Eriikka Hannula-Jouppi, 2001 …

Pediatric Pulmonology, Katariina Sara Eriikka Hannula-Jouppi, 2005 …

American Journal of Medical Genetics, Katariina Sara Eriikka Hannula-Jouppi, 2006 …

Orphanet Journal of Rare Diseases, Katariina Sara Eriikka Hannula-Jouppi, 2006 …

Medical Science Monitor, Katariina Sara Eriikka Hannula-Jouppi, 2007 …

Pediatric research, Katariina Sara Eriikka Hannula-Jouppi, 2007 …

Hannes Tapani Lohi , Genetics, Hannes Tapani Lohi, 2008

Genome Research, Hannes Tapani Lohi, 2008

Journal of Heredity, Hannes Tapani Lohi, 20.06.2008

Nature Genetics, Hannes Tapani Lohi, 2008

Veterinary Journal, Hannes Tapani Lohi, 20.08.2008

Animal Genetics, Hannes Tapani Lohi, 2009

Journal of Heredity, Hannes Tapani Lohi, 20.06.2009

Journal for Molecular Medicine, Hannes Tapani Lohi, 2010

Aarno Palotie , Acted as peer review of a manuscripts: Cell, Aarno Palotie, 2005 2010

CompDisGen/Kaprio

11



Peer review of manuscript in journals: Nature Genetics, European Journal of Human Genetics, Human Molecular Genetics, American Journal of Human Genetics, Nucleic Acid Research, Aarno Palotie, 2005 2010

Samuli Olli Ripatti , Reviewed manuscripts for the Alcoholism: Clinical and Experimental Research, Samuli Olli Ripatti, 2005 2010

Reviewed manuscripts for the Biometrical Journal, Samuli Olli Ripatti, 2005 2010

Reviewed manuscripts for the Biostatistics Journal, Samuli Olli Ripatti, 2005 2010

Reviewed manuscripts for the European Journal of Human Genetics, Samuli Olli Ripatti, 2005 2010

Reviewed manuscripts for the Genetic Epidemiology, Samuli Olli Ripatti, 2005 2010

Reviewed manuscripts for the Journal of Computational and Graphical Statistics, Samuli Olli Ripatti, 2005 2010

Reviewed manuscripts for the Lifetime Data Analysis Journal, Samuli Olli Ripatti, 2005 2010

Päivi Marjaana Saavalainen , European Journal of Gastroenterology & Hepatology, Päivi Marjaana Saavalainen, 01.07.2005 31.07.2005

Reviewer for Eur J Hum Genet, Päivi Marjaana Saavalainen, 26.07.2005

Reviewer for Eur J Hum Genet, Päivi Marjaana Saavalainen, 20.03.2006

Reviewer for Tissue Antigens, Päivi Marjaana Saavalainen, 02.10.2006

Scandinavian Journal of Gastroenterology, Päivi Marjaana Saavalainen, 01.11.2006 30.11.2006


Reviewer for J Med Genet, Päivi Marjaana Saavalainen, 17.07.2008

Reviewer for J Med Genet, Päivi Marjaana Saavalainen, 09.03.2009


Reviewer for Annals of Medicine, Päivi Marjaana Saavalainen, 07.10.2010

Reviewer for International Archives of Allergy and Immunology, Päivi Marjaana Saavalainen, 02.03.2010

Elisabeth Ingrid Maria Widen , Acted as a reviewer in journal of Medical Genetics, Elisabeth Ingrid Maria Widen, 2005

Acted as a reviewer in a journal: European Journal of Human Genetics, Elisabeth Ingrid Maria Widen, 2006 2010

Acted as a reviewer in a journal: Scandinavian Journal of Clinical Investigation, Elisabeth Ingrid Maria Widen, 2006 …

Acted as a reviewer in Journal of Pediatrics, Elisabeth Ingrid Maria Widen, 2009 …

Acted as a reviewer in a journal; Annals of Medicine, Elisabeth Ingrid Maria Widen, 2010

Acted as a reviewer of a manuscript in a journal: American Journal of Human Genetics, Elisabeth Ingrid Maria Widen, 2010

Assessment of candidates for academic posts Jaakko Kaprio , Evaluation for full professorship in Community Medicine and Health Care: Dr. Richard Stevens, Jaakko Kaprio, 2006, United States

Evaluation for tenure track assistant professorship in Psychology: Danielle M Dick, Jaakko Kaprio, 2006, United States

Docentship reviewer: Tomi-Pekka Tuomainen, Jaakko Kaprio, 2007, Finland

Evaluation for Associate Professor of Harvard University: Taru Kinnunen, Jaakko Kaprio, 2007, United States

Evaluation for Associate Professor, Univ of Southern California, Jaakko Kaprio, 2007, United States

Evaluation of Senior Research Fellow-position: Dr. Grant Montgomery, Jaakko Kaprio, 2007, Australia

Evaluation for Full Professor: Alex MacGregor, Jaakko Kaprio, 2008, United Kingdom

Assessment of candidate for academic post: Docentship: Markus Jokela, Jaakko Kaprio, 2009, Finland

Evaluation for promotion to Associate Professor: Valerie Knopik, Jaakko Kaprio, 2009, United States

Professoship evaluation: Päivi Rautava, Jaakko Kaprio, 2009, Finland

CompDisGen/Kaprio

12



Aarno Palotie , Expert evaluator of professorship at the Uppsala University, Aarno Palotie, 2008, Sweden

Elisabeth Ingrid Maria Widen , Assessment of candidate for academic post: Adjunct professor/Docentship: Sirpa Kivirikko, Elisabeth Ingrid Maria Widen, 2005, Finland

Membership or other role in review committee Jaakko Kaprio , Review committee member: EUPHA, Jaakko Kaprio, 01.01.2008 31.12.2010, Portugal

Grant evaluations, Jaakko Kaprio, 2009, United Kingdom

Pre-examiner for PhD, Jaakko Kaprio, 2009

Pre-examiner for PhD thesis, Jaakko Kaprio, 2009

Pre-examiner for PhD, Jaakko Kaprio, 2010

Review of grant applications, Jaakko Kaprio, 2010

Three year grant evaluations, Jaakko Kaprio, 2010 …

Tellervo Korhonen , 12th Annual Conference SRNT Europe, Tellervo Korhonen, 01.05.2010 10.06.2010

Aarno Palotie , Member of International Review Committee of LUMC, University of Leiden, Aarno Palotie, 2005, Netherlands

Samuli Olli Ripatti , Member in review committee: ZonMW, Samuli Olli Ripatti, 2007 …

ERC Advance Grant referee, Samuli Olli Ripatti, 2009 …, Belgium

ERC starting grant referee, Samuli Olli Ripatti, 2009 …, Belgium

Membership or other role in research network Jaakko Kaprio , Elected Member: Finnish Academy for Science and Letters, Jaakko Kaprio, 2009 …, Finland

Leena Palotie , Human Genome Organization: President, Leena Palotie, 2005 2007

Samuli Olli Ripatti , Member in Nordic Center of Excellence for Disease Genetics: Harmonization of control database, Samuli Olli Ripatti, 2007 2010

Network in Academia:P3G, Working Group 2, Samuli Olli Ripatti, 2008 …

Project manager in Biostatistics group (GENESTAT) in EU FP6 coordinated action PHOEBE, Samuli Olli Ripatti, 2008 2009

Steering Group Member in EU FP7 project ENGAGE, cardiovascular risk factors, statistical genetics, Samuli Olli Ripatti, 2008 …

Janna Saarela , Nordic MS Genetics Network: Finnish representative, Janna Saarela, 01.01.2004 …

National Public Health Institute: Member of DNA Steering group, Janna Saarela, 01.01.2006 31.12.2008, Finland

Finnish representative in the International MS Genetics consortium (IMSGC), Janna Saarela, 01.01.2008 …

Biocenter Finland “Genome-wide methods” network:Member, Janna Saarela, 01.01.2009 …, Finland

Tiinamaija Tuomi , Board member of HBGS, Tiinamaija Tuomi, 2003 …, Finland

Member of DIAGRAM (Diabetes Genetics Replication and Meta-Analysis), Tiinamaija Tuomi, 2008 …

Steering committee member of Transmed, Tiinamaija Tuomi, 2010 …, Finland

CompDisGen/Kaprio

13



Membership or other role in national/international committee, council, board Jaakko Kaprio , Finnish Epidemiological Society, Jaakko Kaprio, 2000 …, Finland

Expert Member in the Academy of Finland, Jaakko Kaprio, 01.01.2002 31.12.2007, Finland

Agence National de Recherche, Jaakko Kaprio, 01.01.2005 31.12.2005, France

Cimo, Jaakko Kaprio, 01.01.2005 31.12.2005, Finland

Finnish Epidemiological Society, Jaakko Kaprio, 01.01.2005 31.12.2005, Finland

International Congress on Behavior Medicine, Jaakko Kaprio, 01.01.2005 31.12.2005, United States

International Congress on Behavior Medicine, Jaakko Kaprio, 01.01.2005 31.12.2005, United States

International Congress on Behavior Medicine, Jaakko Kaprio, 01.01.2005 31.12.2005

International Society for Twin Studies, Jaakko Kaprio, 01.01.2005 31.12.2005, Australia

International Society for Twin Studies, Jaakko Kaprio, 01.01.2005 31.12.2005

International Society for Twin Studies, President, Jaakko Kaprio, 2005 2007, Australia

President for the International Society for Twin Studies, Jaakko Kaprio, 2005 2007, Australia

Society for Research on Nicotine and Tobacco, Jaakko Kaprio, 01.01.2005 31.12.2005, United States

Society for Research on Nicotine and Tobacco, Jaakko Kaprio, 01.01.2005 31.12.2005

Swedish Research Council, Jaakko Kaprio, 01.01.2005 31.12.2005, Sweden

Swedish Research Council, Jaakko Kaprio, 01.01.2005 31.12.2005

European research advisory board, Jaakko Kaprio, 01.01.2006 31.12.2006, France

Finnish Epidemiolgical Society, Jaakko Kaprio, 01.01.2006 31.12.2006, Finland


Käyttäytymislääketieteen jaos, Sosiaalilääketieteen yhdistys 2006, Jaakko Kaprio, 01.01.2006 31.12.2006, Finland

Käyttäytymislääketieteen jaos, Sosiaalilääketieteen yhdistys 2006, Jaakko Kaprio, 01.01.2006 31.12.2006

Paulo Foundation, Jaakko Kaprio, 01.01.2006 31.12.2008, Finland

European research advisory board, Jaakko Kaprio, 01.01.2007 31.12.2007, France




Center for Gender Medicine at Karolinska Institute, Jaakko Kaprio, 01.01.2008 31.12.2008, Sweden


French National Research Agency /AnR) programme, "GENOPAT: From the gene to the physiopathology, Jaakko Kaprio, 01.01.2008 31.12.2008, France

Helsinki University Hospital Fund (EVO) evaluation board, Jaakko Kaprio, 2008 …


Society for Research on Nicotine and Tobacco, Jaakko Kaprio, 01.01.2008 31.12.2008, Italy

Academy of Finland Medical Research Council member, Jaakko Kaprio, 2010 2012, Finland

Finnish Cancer Foundation governing board member, Jaakko Kaprio, 2010 2012, Finland

Ulla Heidi Broms , Sosiaalilääketieteen yhdistys; Käyttäytymislääketieteen jaos, Ulla Heidi Broms, 01.01.2005 31.12.2005, Finland

Finnish Epidemiological Society, Ulla Heidi Broms, 01.04.2008 31.12.2010, Finland

Anna Keski-Rahkonen , Academy for Eating Disorders: Conference Committee, Anna Keski-Rahkonen, 01.01.2005 31.12.2005, United States

CompDisGen/Kaprio

14



Academy for Eating Disorders: International Task Force, Anna Keski-Rahkonen, 01.01.2005 31.12.2005, United States

Tellervo Korhonen , International Society of Behavioral Medicine, Tellervo Korhonen, 2008 2011, Finland

Current Care Working Group, Tellervo Korhonen, 2010 …, Finland

Suoma Eeva Matilda Saarni , Suomen Lihavuustutkijat ry, Suoma Eeva Matilda Saarni, 01.01.2004 31.12.2005, Finland

Suomen Lääketieteen Filosofian Seura, Suoma Eeva Matilda Saarni, 01.04.2005 31.12.2010, Finland

Nuorten lääkärien yhdistys, Suoma Eeva Matilda Saarni, 01.01.2008 31.12.2008, Finland

Suomen Lihavuustutkijat ry, Suoma Eeva Matilda Saarni, 01.01.2008 31.12.2008, Finland

Suomen Lääketieteen Filosofian Seura ry, Suoma Eeva Matilda Saarni, 01.01.2008 31.12.2008, Finland

Kaisu Keskitalo , ETS:n aistinvaraisen tutkimuksen jaosto, Kaisu Keskitalo, 2008, Finland

ETS:n hallitus, Kaisu Keskitalo, 2008, Finland

Juha Kere , Board of Directors, Finnish Cancer Foundation and Finnish Foundation for Cancer Research, Juha Kere, 1999 2007, Finland

Scientific Advisory Board, The Centre for Applied Genomics, The Hospital for Sick Children, Juha Kere, 1999 …, Canada

Steering Committee, Graduate School of Computational Biology (ComBi), University of Helsinki, Juha Kere, 1999 …, Finland

Biocentrum Helsinki, Juha Kere, 2000 2006, Finland

Medical Board, Sigrid Jusélius Foundation, Juha Kere, 2000 …, Finland

Scientific Advisor, Finnish Genome Center, Juha Kere, 2001 2007, Finland

Board of Directors, Finnish Genome Center, Juha Kere, 2002 2007, Finland

Co-founder and Board of Directors, GeneOS Ltd., Juha Kere, 2002 2007, Finland

Scientific Advisory Board, Spanish Genotyping Network (SGN), Juha Kere, 2003 …, Spain

Nobel Assembly (for the Prize in Physiology or Medicine), Juha Kere, 2004 …, Sweden

Nobel Committee (for the Prize in Physiology or Medicine), Juha Kere, 2004 …, Sweden

Biocentrum Helsinki, Juha Kere, 2007 2010, Finland

European Molecular Biology Organization (EMBO), Juha Kere, 2007

Member of advisory committee for Assistant Professor of Medical Genetics, Juha Kere, 2007, Sweden

Member of advisory committee for Strategic Professor on genome integrity, Juha Kere, 2007, Sweden

Cluster of Life Science Advisory Council (CLAC), Juha Kere, 2008 …, Japan

Kimmo Kontula , Member of The Finnish Medical Society Duodecim, Kimmo Kontula, 1986 …, Finland

Member of the Scientific Board - The Jalmari and Rauha Ahokas Foundation, Kimmo Kontula, 1989 2005, Finland

Member of Steering Committee - MD PhD Program of the Faculty of Medicine, University of Helsinki, Kimmo Kontula, 1994 2006, Finland

Suomalainen Tiedeakatemia, Kimmo Kontula, 1994 …, Finland

Member of the Committee for the Medical Nomenclature, Duodecim, Kimmo Kontula, 1995 …, Finland

Member of the Board of Directors, The Paavo Nurmi Foundation, Kimmo Kontula, 1996 …, Finland

Chairman of the Board of Directors, The Finnish Cultural Foundation, Kimmo Kontula, 2001 2006, Finland

Puheenjohtaja, Suomen Kulttuurirahaston hallitus, Kimmo Kontula, 2001 2006, Finland

Vice Chairman of the Board for the Basic Medical Examination, Kimmo Kontula, 2002 2006, Finland

Member of the Council, The Finnish Foundation for Medical Research, Kimmo Kontula, 2004 …, Finland

CompDisGen/Kaprio

15



Chairman of the Board of Directors of The Finnish Medical Society Duodecim, Kimmo Kontula, 2005 2007, Finland

Member of the Board of Directors, The Finnish National Theatre, Kimmo Kontula, 2005 …, Finland

Member of the Council, The Finnish Cultural Foundation, Kimmo Kontula, 2006 …, Finland

Chairman of the Executive Group of the Research Programs, Faculty of Medicine, University of Helsinki, Kimmo Kontula, 2007 2009, Finland

Chairman of the Faculty Administrative Committee, Faculty of Medicine, University of Helsinki, Kimmo Kontula, 2007 2009, Finland

Chairman of the Regional Board for Specialist Education, Faculty of Medicine, University of Helsinki, Kimmo Kontula, 2007 2009, Finland

Dean and Chairman of the Faculty Administrative Committee, Faculty of Medicine, University of Helsinki, Kimmo Kontula, 2007 2009, Finland

Johtikunnan puheenjohtaja, Kimmo Kontula, 2007 2009, Finland

Member of the Board of Directors, The Institute for Molecular Medicine Finland (FIMM), Kimmo Kontula, 2007 2010, Finland

Member of the Collegium of the University of Helsinki, Kimmo Kontula, 2007 2009, Finland

Chairman of the Board of Directors, National Library for Health Sciences, Kimmo Kontula, 2008 2009, Finland

Member of the Executive Group, Helsinki University Central Hospital, Kimmo Kontula, 2008 2009, Finland

Chairman of the Board of Palmenia Centre for Continuing Education, University of Helsinki, Kimmo Kontula, 2010 …, Finland

Chairman of the Board of UniSport, University of Helsinki, Kimmo Kontula, 2010 …, Finland

Chairman, Board of Directors, FIMM, Kimmo Kontula, 2010 …

Member of the Surveillance Group, Helsinki University Central Hospital, Kimmo Kontula, 2010 …, Finland

Hannes Tapani Lohi , American Society of Human Genetics, Hannes Tapani Lohi, 2008

Biocentrum Helsinki, Hannes Tapani Lohi, 01.01.2008 31.12.2010, Finland

Finnish Professor Association, Hannes Tapani Lohi, 2008

Member of Biocentrum Helsinki, Hannes Tapani Lohi, 2008 2013, Finland

Member of the Editorial Scientific Board of the Journal of Epithelial Biology and Pharmacology (JEBP), Hannes Tapani Lohi, 2008 …, Finland

Member of the Nordic Center of Excellence in Disease Genetics, Hannes Tapani Lohi, 2008 …, Finland

Member of the Steering Committee of the EU-funded LUPA project for canine genomics, Hannes Tapani Lohi, 2008 2012

Nordic Center of Excellence in Disease Genetics, Hannes Tapani Lohi, 01.08.2008

Nordic Center of Excellence in Disease Genetics, Hannes Tapani Lohi, 01.01.2008 31.12.2008

The Steering Committee of the EU-funded LUPA project for dog genomics, Hannes Tapani Lohi, 01.01.2008 31.12.2012

Member of the "Genomic selection" Follow-up Committee for the Ministry of Agriculture and Forestry, Hannes Tapani Lohi, 2009 …, Finland

Dog Health Research Fund, Hannes Tapani Lohi, 01.01.2010 31.12.2012, Finland

Member of the Board of the Research Programs Unit, Faculty of Medicine, Hannes Tapani Lohi, 2010 …

Member of the Committee of the Research and Postgraduate Education Planning, Faculty of Veterinary Medicine, Hannes Tapani Lohi, 2010 …

Member of the GSPB-graduate school evaluation panel, Hannes Tapani Lohi, 2010 …, Finland

Vice Member of the Board of the Institute of Biotechnology, Hannes Tapani Lohi, 2010 …, Finland

Aarno Palotie , European Scientific Science Foundation Functional Genome Programme, Aarno Palotie, 2004 2005

GenomEUtwin Steering Group, Aarno Palotie, 2004 2005

Helsinki Biomedical Graduate School, Aarno Palotie, 2004 2005, Finland

Helsinki Computational Biology Graduate School, Aarno Palotie, 2004 2005, Finland

CompDisGen/Kaprio

16



Mehiläisen tieteellinen neuvottelukunta, Aarno Palotie, 2004 2005, Finland

Member of Study Section, Assays and Methods Development, NIH, Aarno Palotie, 2004 2005, United States

NIH Study Section Biotechnical Task Committee, Aarno Palotie, 2004 2005, United States

Nordic Committee of Education, Aarno Palotie, 2004 2005

Chair of Evaluation Panel, Academy of Finland, Aarno Palotie, 2005, Finland

Chair of Evaluation Panel, The Belgian Science Policy (BELSPO), Aarno Palotie, 2005, Belgium

Member of Evaluation Panel, Wallenberg Consortium North, technology platforms, Aarno Palotie, 2005, Sweden

Member of Evaluation Panel, The swedish Research Council for Medicine, Aarno Palotie, 2006, Sweden

Board member of Biocentrum Helsinki, Aarno Palotie, 2007 2008, Finland

Evaluation Panel, Uppsala University: Quality and Renewal Evauation, Aarno Palotie, 2007 …, Sweden

External Evaluation Expert, Estonian Research Council, Aarno Palotie, 2007, Estonia

Member of Evaluation Panel, Wallenberg Consortium North, technology platforms, Aarno Palotie, 2008, Sweden

Member of the search committee for virology at the Wellcome Trust Sanger Instiute, Aarno Palotie, 2008, United Kingdom

Leena Palotie , European Molecular Biology Organization (EMBO), Leena Palotie, 1991 2010, Germany

Finnish Academy of Sciences and Letters, Leena Palotie, 01.01.1993 11.03.2010, Finland

Scientific Advisory Board, Center for Molecular Medicine, Karolinska Institutet, Leena Palotie, 1996 2010, Sweden

European Academy of Sciences (Academiae Europeae), Leena Palotie, 1999 2010, Belgium

Scientific Advisory Board of the Genome Research Programme, Foundation for Strategic Research, Leena Palotie, 1999 2010, Sweden

Board of the Genetics Prize of the Peter Gruber Foundation, Leena Palotie, 01.01.2001 31.12.2009, United States

Member of the Scientific Advisory Board of British Biobanks, Leena Palotie, 2001 2010, United Kingdom

The Scientific Advisory Board of Biobanks, Leena Palotie, 2001 2010, Netherlands

Member of the Scientific Advisory Board of the Shanghai Genome Center, Leena Palotie, 2002 2010

Societas Scientiarum Fennica, Leena Palotie, 2002 2010, Finland

Institutional Advisory Board of VIB, Ghent, Leena Palotie, 01.01.2003 31.12.2009, Belgium

Member of VIB Departmental Evaluation Board, University of Antwerp, Leena Palotie, 2003 2010, Belgium

Vlaams Interuniversitair Instituut voor Biotechnologie Institutional evaluation board, Leena Palotie, 2003 2010, Belgium

Board of Publicly Funded Population Projects in Genomics (P3G), Leena Palotie, 01.01.2004 11.03.2010, Canada

European Society of Human Genetics, Leena Palotie, 01.01.2004 31.12.2005, Austria

Helsingin yliopisto, tutkimusneuvosto, Leena Palotie, 01.01.2004 31.12.2006, Finland

Populations and Public Health Strategy Committee, Wellcome Trust: Chair, Leena Palotie, 2004 2010, United Kingdom

Board of European Research Council (ERC, Leena Palotie, 01.01.2005 11.03.2010

Committee member of Nordisk Forsknings Committee, Novo Nordisk Foundation, Leena Palotie, 2005

European Academy of Sciences (Academiae Europeae), Leena Palotie, 01.01.2005 31.12.2005, Belgium

European Molecular Biology Organization (EMBO), Leena Palotie, 01.01.2005 31.12.2005, Germany

Evaluation Board Member, Uppsala University, Leena Palotie, 2005, Sweden

HUGO - The Human Genome Organisation, Leena Palotie, 01.01.2005 31.12.2007, United Kingdom

Member of Board of Directors of P3G, Leena Palotie, 2005

Member of EMBO Publications & Electronic Information Committee, Leena Palotie, 2005

MolPAGE Scientific Advisory Board, Leena Palotie, 2005 2010, United Kingdom

National Academy of Sciences, Leena Palotie, 01.01.2005 31.12.2005, Finland

CompDisGen/Kaprio

17



Scientific Advisory Board of European Research Council, ERC, Leena Palotie, 2005 2010, Belgium

The consequences, opportunities and challenges of modern biotechnology for Europe (Bio4EU), Leena Palotie, 01.01.2005 31.12.2006, Belgium

Fondation Louis Jeantet, Leena Palotie, 01.01.2006 11.03.2010, Switzerland

Foreign Associate Member in the Institute of Medicine of the National Academies, Leena Palotie, 01.01.2006 11.03.2010, United States

International Advisory Panel (IAP) - Government of Catalonia - Catalan Pact for Research, Leena Palotie, 01.01.2007 11.03.2010

Future Trends Forum (FTF), Bankinter Foundation of Innovation, Leena Palotie, 01.01.2008 31.12.2010, Spain

Member, Board of Danish National Research Foundation, Leena Palotie, 2009 2010, Denmark

Päivi Marjaana Saavalainen , Helsingin Biolääketieteellinen Tutkijakoulu, Päivi Marjaana Saavalainen, 01.05.2005 31.10.2005

Biocentrum Helsinki, Päivi Marjaana Saavalainen, 01.01.2008 31.12.2010, Finland

Helsinki Graduate School in Biotechnology and Molecular Biology, Päivi Marjaana Saavalainen, 01.01.2008 31.12.2010, Finland

Research Program Unit, Päivi Marjaana Saavalainen, 01.06.2010 …

Marja-Riitta Taskinen , Claude Bernard Award Nomination Committee, Marja-Riitta Taskinen, 01.01.2005 31.12.2005

European Atherosclerosis Society (EAS), Marja-Riitta Taskinen, 01.01.2005 31.12.2005

International Atherosclerosis Society, Marja-Riitta Taskinen, 01.01.2005 31.12.2005

Metabolic Syndrome Institute, Marja-Riitta Taskinen, 01.01.2005 31.12.2005

European Atherosclerosis Society (EAS), Marja-Riitta Taskinen, 01.01.2006 2008

International Atherosclerosis Society (IAS), Marja-Riitta Taskinen, 01.01.2006 31.12.2006

EAS/ ESC Guideline Committee on Management of dyslipidemias, Marja-Riitta Taskinen, 2009 …

Tiinamaija Tuomi , Board Member of Suomen Diabetestutkijat ja Diabetologit ry, Tiinamaija Tuomi, 1999 …, Finland

Suomen Diabetestutkijat ja Diabetologit ry, Tiinamaija Tuomi, 1999 …, Finland

Membership or other role in public Finnish or international organization Jaakko Kaprio , Acted as reviewer of the Academy of Finland applications, Jaakko Kaprio, 2002 2007, Finland

Department Head and Chair of Steering Board: Dept of Public Health, Helsinki, Jaakko Kaprio, 2004 2008, Finland

HY Yhteiskunnallisen vuorovaikutuksen työryhmän jäsen, Jaakko Kaprio, 01.01.2004 31.12.2006, Finland

Lääk. tdk tutkimusneuvoston jäsen, Jaakko Kaprio, 01.01.2004 31.12.2006, Finland

Lääket. tdk tutkimusneuvoston jäsen, Jaakko Kaprio, 01.01.2004 31.12.2006, Finland

Lääket.tdk tutkimusneuvoston jäsen, Jaakko Kaprio, 01.01.2004 31.12.2006, Finland

Vaalikollegion jäsen, Jaakko Kaprio, 01.01.2004 31.12.2006, Finland


Vaalikollegion jäsen, Helsingin yliopisto, Jaakko Kaprio, 01.01.2004 31.12.2006, Finland

HY Yhteiskunnallisen vuorovaikutuksen tyröryhmän jäsen, Jaakko Kaprio, 01.01.2005 31.12.2005, Finland

HY Yhteiskunnallisen vuorovaikutuksen tyröryhmän jäsen, Jaakko Kaprio, 01.01.2005 31.12.2006, Finland

Lääket.tdk tutkimusneuvoston jäsen, Jaakko Kaprio, 01.01.2005 31.12.2005, Finland


Lääk. tdk tutkimusneuvoston jäsen, Jaakko Kaprio, 01.01.2006 31.12.2006, Finland

Vaalikollegion jäsen, Helsingin yliopisto, Jaakko Kaprio, 01.01.2006 31.12.2006, Finland

CompDisGen/Kaprio

18




HY, yliopistouudistuksen tutkimuksen projektiryhmä, Jaakko Kaprio, 01.01.2008 31.12.2010, Finland

International Society for Twin Studies, Past-President, Jaakko Kaprio, 01.01.2008 31.12.2010, Australia


Ulla Heidi Broms , Asiantuntijajäsen Toinen Valtakunnallinen Tupakka ja Terveyspäivän suunnittelutoimikunta, Filha ry., KTL, Ulla Heidi Broms, 01.10.2005

12.12.2006, Finland

H:gin yliopisto, Kansanterveystieteen laitos, johtoryhmän jäsen, Ulla Heidi Broms, 01.01.2005 20.03.2005, Finland

HY, Kansanterveystieteen laitoksen johtoryhmän jäsen, Ulla Heidi Broms, 01.01.2006 31.12.2006

Tellervo Korhonen , Society for Research on Nicotine and Tobacco European Board, Tellervo Korhonen, 01.01.2009 31.12.2011

Kimmo Kontula , Lääketieteen sanastoolautakunta, jäsen, Kimmo Kontula, 1995 …, Finland

Paavo Nurmen Säätiön hallitus, Kimmo Kontula, 1996 …

Käypä hoito -johtoryhmän jäsen, Kimmo Kontula, 2005 2007, Finland

Kustannus Oy Duodecimin hallitus, Kimmo Kontula, 2006 2008, Finland

Hannes Tapani Lohi , Ministry of Social and Health Affairs, Hannes Tapani Lohi, 19.08.2006 01.08.2008, Finland

Ministry of Social and Health Affairs, Hannes Tapani Lohi, 19.08.2006 01.08.2008, Finland

Health Club of the Finnish hound Association, Hannes Tapani Lohi, 01.01.2007 31.12.2011, Finland

Health Club of the Finnish hound Association, Hannes Tapani Lohi, 01.01.2008 31.12.2008, Finland

MTT Agrifood Research Finland, Hannes Tapani Lohi, 01.06.2009 31.12.2011, Finland

Katriina Annikki Tiira , , Invalidiliitto, Avustajakoiratyöryhmä, Katriina Annikki Tiira, 01.01.2005 31.12.2005, Finland

Leena Palotie , Orion Board Member, Leena Palotie, 01.01.2004 11.03.2010, Finland

Faculty of Medicine, Lund University, Leena Palotie, 01.01.2005 31.12.2010, Sweden

Novo Nordisk Fonden, scientific board, Leena Palotie, 01.01.2005 11.03.2010, Denmark

UNIK International Expert Panel, Minister of Science, Technology and Innovation, Leena Palotie, 01.01.2008 11.03.2010, Denmark

Marja-Riitta Taskinen , Liikuntatieteen jaosto, Marja-Riitta Taskinen, 01.08.2007 31.12.2011, Finland

Tiinamaija Tuomi , Chair of the Medical Advisory Board of the Finnish Diabetes Association, Tiinamaija Tuomi, 2005 …, Finland

Membership or other role of body in private company/organisation Jaakko Kaprio , Monikkoperheet ry:n asiantuntija "kummi", 10v juhlassa sain kunniaviirin., Jaakko Kaprio, 01.01.2005 31.12.2005, Finland

Monikkoperheet ry:n asiantuntija "kummi", 10v juhlassa sain kunniaviirin., Jaakko Kaprio, 01.01.2005 31.12.2005, Finland

Monikkoperheet ry:n asiantuntija, Jaakko Kaprio, 01.01.2006 31.12.2006, Finland

Monikkoperheet ry:n asiantuntija, Jaakko Kaprio, 01.01.2007 31.12.2007, Finland

Ulla Heidi Broms , Sosiaalilääketieteen yhdistys ry, Käyttäytymislääketieteen jaos, Ulla Heidi Broms, 01.01.2005 31.12.2006

CompDisGen/Kaprio

19



Kimmo Kontula , Eteläsuomalainen osakunta, inspehtori, Kimmo Kontula, 01.03.2000 28.02.2010, Finland

Hallintoneuvoston jäsen, Kimmo Kontula, 2004 …, Finland

Member of the Board of Culminatum Innovation Ltd., Kimmo Kontula, 2010 …, Finland

Participation in interview for written media Jaakko Kaprio , HY IT 4/01, Jaakko Kaprio, 04.07.2006, Finland

Interview in Ilta-Sanomat newspaper, Jaakko Kaprio, 04.07.2006, Finland

Interview in Mediuutiset (in English: Medical News), Jaakko Kaprio, 04.07.2006, Finland

Interview in Sosiaalivakuutus magazine, Jaakko Kaprio, 02.06.2006, Finland

Press Release in HGM2006 Meeting, Jaakko Kaprio, 31.05.2006, Finland

Jukka Tapani Lehtonen , Esitelmä Tallinnan eläintarhassa, Jukka Tapani Lehtonen, 18.07.2001 31.12.2011, Madagascar

Suomi-Madagaskar seura ry:n Madagaskar-ilta, Luonnontieteellisellä keskusmuseolla, Jukka Tapani Lehtonen, 05.03.2003 31.12.2011, Belgium

Tutkijaliiton kesäkoulu, Järvenpää, Jukka Tapani Lehtonen, 30.08.2008 31.12.2011, Madagascar

Hannes Tapani Lohi , Newspaper article in Helsingin Sanomat, Hannes Tapani Lohi, 02.2005, Finland

Interview in Koirat magazine, Hannes Tapani Lohi, 2007, Finland

Newspaper interview in Helsingin Sanomat, Hannes Tapani Lohi, 05.12.2007, Finland

Newspaper interview in Helsingin Sanomat, Hannes Tapani Lohi, 05.2007, Finland

Interview in Kemia magazine, Hannes Tapani Lohi, 2008, Finland

Newspaper article in Pohjolan Sanomat, Hannes Tapani Lohi, 05.10.2008

Newspaper interview in Kaleva, Hannes Tapani Lohi, 29.09.2008, Finland

Newspaper interview in Tiede Magazine, Hannes Tapani Lohi, 2008, Finland

Article in Demodex: Geenit: koirien geenitutkimus auttaa rodunjalostusta - ja ihmistä!, Hannes Tapani Lohi, 2009, Finland

Article in Springeri Magazine, Hannes Tapani Lohi, 2009, Finland

Interview in Seura Magazine, Hannes Tapani Lohi, 17.09.2009, Finland

Newspaper interview in Savon Sanomat, Hannes Tapani Lohi, 25.04.2009, Finland

Article in Ajokoiramies, Hannes Tapani Lohi, 05.2010, Finland

Interview in Metsästäjä Magazine, Hannes Tapani Lohi, 2010, Finland

Newspaper article in Kauppalehti, Hannes Tapani Lohi, 01.02.2010, Finland

Newspaper interview in Helsingin Sanomat, Hannes Tapani Lohi, 2010, Finland

Newspaper interview in Helsingin Sanomat Kuukausiliite (monthly supplement), Hannes Tapani Lohi, 2010, Finland

Presentation for international press, Hannes Tapani Lohi, 29.11.2010, Finland

Leena Palotie , Interview in BiotechScandinavia Magazine, Leena Palotie, 04.2005

Interview in Diabetes magazine, Leena Palotie, 2005, Finland

Interview in Discover Magazine, Leena Palotie, 04.2005, United States

Interview in Europa Magazine, Leena Palotie, 2005, Finland

Interview in the Lancet, Leena Palotie, 24.09.2005 30.09.2005, United States

CompDisGen/Kaprio

20



Interview in "Avain, Nyckeln" Magazine, Leena Palotie, 2006, Finland

Interview in "Ita-Savo" newspaper, Leena Palotie, 14.06.2006, Finland

Interview in "Made in Holland" Magazine, Leena Palotie, 04.2006, Netherlands

Interview in "Tiede" Magazine - In English "Science" Magazine, Leena Palotie, 2006, Finland

Interview in "Yliopistopaino" Magazine, Leena Palotie, 01.2006, Finland

Interview in Finnfacts Magazine, Leena Palotie, 2006, Finland

Interview in Mediuutiset Magazine, Leena Palotie, 17.11.2006, Finland

Interview in Orion Magazine, Leena Palotie, 2006, Finland

Interview in "Helsingin Sanomat, kuukausiliite", Leena Palotie, 04.2007, Finland

Interview in "Hyva Terveys" Magazine (in English "Good Health" Magazine, Leena Palotie, 01.2007, Finland

Interview in "PRIMA" Magazine, Leena Palotie, 2007, Finland

Interview in Galenos magazine (Orion Pharma), Leena Palotie, 24.08.2007, Finland

Interview in HUSARI Magazine, Leena Palotie, 2007, Finland

Interview in Nordicum, Scandinavian Business Magazine, Leena Palotie, 05.2007

Interview in Oulu Magazine, Leena Palotie, 2007, Finland

Interview in Reader´s Digest, Leena Palotie, 12.2007, Finland

Interview in Universitat Helsingiensis, Leena Palotie, 2007, Finland

Interview in Diabetes magazine, Leena Palotie, 08.2008, Finland

Interview in Promo magazine, Leena Palotie, 02.2008, Finland

Interview in Newspaper "Karjalainen", Leena Palotie, 08.02.2009, Finland

Samuli Olli Ripatti , Interview in "Ajassa" magazine "Ambassador of genes", personal profile of Samuli Ripatti, Samuli Olli Ripatti, 09.2010 …

Interview in Tiede magazine ("Science"): "Where do Finns come from?",, Samuli Olli Ripatti, 09.2010

Samuli Ripatti´s Interview in Helsingin Sanomat about the origin on Finns and 1000 genomes project, Samuli Olli Ripatti, 17.03.2010

Tiinamaija Tuomi , Newspaper interview in Helsingin Sanomat, Tiinamaija Tuomi, 2005, Finland

Newspaper interview in Helsingin lääkärilehti, Tiinamaija Tuomi, 2005, Finland

Interview in HyväTerveys Magazine, Tiinamaija Tuomi, 2006, Finland

Interview in Diabetes Magazine, Tiinamaija Tuomi, 2009, Finland

Interview in Diabetes Magazine (Finnish Diabetes Association), Tiinamaija Tuomi, 2010, Finland

Participation in radio programme Jaakko Kaprio , Interview in Yleisradio (National Radio channel), Jaakko Kaprio, 04.07.2006, Finland

Tellervo Korhonen , BBC Radio Program: Health Check, Tellervo Korhonen, 21.05.2007, United Kingdom

Tupakoinnin lopettaminen on vaikeampaa kuin luullaan, Tellervo Korhonen, 11.03.2010, Sweden

Kaisu Keskitalo , MTV3 News, Kaisu Keskitalo, 07.03.2008

Yle News, Kaisu Keskitalo, 07.03.2008

Yle X3M Radio, Kaisu Keskitalo, 06.03.2008

Yle1 Radio Ykkösaamu, Kaisu Keskitalo, 11.03.2008

CompDisGen/Kaprio

21



Katariina Sara Eriikka Hannula-Jouppi , , The axon guidance receptor geme ROBO1 is a candidate gene fir developmental dyslexia. PLOS Genetics 2005, Katariina Sara Eriikka Hannula-Jouppi, 2005, Finland

Elina Salmela , , Haastattelu YLE:n radiouutisissa, Elina Salmela, 24.10.2008

Jukka Tapani Lehtonen , Yle radio yksi, ohjelma: Kasviretkiä kaukomaille: Dodon vihreä saari - Madagaskar, Jukka Tapani Lehtonen, 20.03.2007 31.12.2011, Belgium

Hannes Tapani Lohi , Radio interview on Reseptori, Hannes Tapani Lohi, 19.03.2010, Finland

Leena Palotie , Interview in National Radio YLE 1, Leena Palotie, 30.10.2009, Finland

Samuli Olli Ripatti , Samuli Ripatti´s interview in Finnish National Radio1, Reseptori Science Program about "Finnish genes", Samuli Olli Ripatti, 07.07.2010

Päivi Marjaana Saavalainen , Radio interview, Päivi Marjaana Saavalainen, 04.03.2010, Finland

Elisabeth Ingrid Maria Widen , Interview in Finnish National Radio 1, Reseptori Science Program, Elisabeth Ingrid Maria Widen, 04.2010, Finland

Participation in TV programme Katariina Sara Eriikka Hannula-Jouppi , , The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia. PLOS Genetics 2005, Katariina Sara Eriikka Hannula-Jouppi, 2005, Finland

Ville Pertti Pulkkinen , , Interview on YLE Prisma TV program, Ville Pertti Pulkkinen, 02.09.2010

Elina Salmela , , Haastattelu YLE:n TV-uutisissa, Elina Salmela, 24.10.2008

Kimmo Kontula , Television interview: Kenen verenpaine hoitoon?, Kimmo Kontula, 24.08.2006, Finland

Hannes Tapani Lohi , Television interview on MOT, Hannes Tapani Lohi, 02.2007, Finland

Television interview on MTV 3, Hannes Tapani Lohi, 04.2007, Finland

Television interview on TV 2 (YLE channel 2), Hannes Tapani Lohi, 08.2007, Finland

Television interview on Teema, Hannes Tapani Lohi, 2009, Finland

Aarno Palotie , Interview in Prisma Studio - Finnish National TV - YLE TV 1, Aarno Palotie, 20.11.2010

Leena Palotie , Lukuisia radio-, TV- ja lehtihaastatteluja, muun muassa kaksi Heurekan yleisöluentoa sekä esiintyminen Suuret Suomalaiset- ja Maan Mainiot-televisio-ohjelmissa, Leena Palotie, 02.06.2006, Finland

Lukuisia radio-, TV- ja lehtisaastatteluja ja kolumneja, mm. Arto Nyberg -ohjelma, Leena Palotie, 30.12.2007, Finland

TV prgram: Aamusydämellä, Leena Palotie, 06.12.2009, Finland

TV program: 45 minuuttia, Leena Palotie, 09.12.2009, Finland

CompDisGen/Kaprio

22



Samuli Olli Ripatti , Interview in seven o´clock news in MTV3 Finnish National TV, Samuli Olli Ripatti, 16.03.2010

TV program "Puoli seitsemän", Samuli Olli Ripatti, 14.04.2010

Janna Saarela , Kaupalliset geenitestit, Janna Saarela, 12.11.2009, Finland

Tiinamaija Tuomi , Television interview on Prisma Studio, Tiinamaija Tuomi, 01.01.2003 31.12.2011, Finland

Elisabeth Ingrid Maria Widen , TV-program Arto Nyberg in YLE TV1, Elisabeth Ingrid Maria Widen, 18.04.2010

Participation in interview for web based media Tellervo Korhonen , Smoking behaviour as a predictor for depression, Tellervo Korhonen, 29.05.2007

Leena Palotie , Interview on SciVee, Leena Palotie, 2008, United States

Päivi Marjaana Saavalainen , Press release, Päivi Marjaana Saavalainen, 01.03.2010


Web of Science(WoS)-based bibliometrics of the RC’s publications data 1.1.2005-31.12.2010 by CWTS, Leiden University, the Netherlands

Research Group: Kaprio J

Basic statistics Number of publications (P) 890 Number of citations (TCS) 12,104 Number of citations per publication (MCS) 13.76 Percentage of uncited publications 19% Field-normalized number of citations per publication (MNCS) 2.17 Field-normalized average journal impact (MNJS) 1.94 Field-normalized proportion highly cited publications (top 10%) 2.21 Internal coverage .89

Trend analyses

MNCS

THCP10

MNJS

Collaboration

Performance (MNCS) by collaboration type


Web of Science(WoS)-based bibliometrics of the RC’s publications data 1.1.2005-31.12.2010 by CWTS, Leiden University, the Netherlands

Research profile

University of Helsinki Administrative Publications 80/34 Evaluations ISBN 978-952-10-7454-7 (PDF) ISSN 1795-5513 (Online) Internet address: http://www.helsinki.fi/julkaisut/aineisto/rc_evaluation2012/hallinnon_julkaisuja_80_34_2012.pdf

International Evaluation of Research and Doctoral Training ...

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