Innate Immune Responses Against Corona virus Infection...Title: SARS-CoV-2 (COVID-19) poster Author:...
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- Fusion Cell TMPRSS2 0 Translation Viral RNA Polypeptide chains 0 Translation and RNA replication 0 Packaging References 0 Virion release Healthy Pulmonary epithelium co4+ T cell Circulation • • No symptoms J Clin Invest. 2020 May 1; 130(5):2202-2205. Science 367(6485), 1412-14 13 (2020). • ..,.-.. cos+ T cell • - SARS-CoV-2 Virus Entry COVID-19 +E--=:;~ - RNA-dependent RNA polymerase ., C )) ------------------------- -----.. :r' "'-- Golgi Endoplasmic reticulum I I I I I' " ( /: 1'1 I i /! )) / , di I I / ._ /II a,j l ,, I ,1/j"' !I I I / / / I /1/ / / ( / • ; rl JI 1 1/ If 1/,J//11// I I I I I / I 1 \ I Moderate COVID-19 Alveolar type II cells _& (ACE2 positive) ... SAR.oV-2 Macrophage and monocyte i • TNF-a •• IFN-y-expressing co4+ T cell i • IL-6 •• t Cytokine levels • • ..,.-.. Fever, cough, fatigue, myalgia I IL-6 Lymphocytes, co4+ T cells, cos+ T cells i • IL-10 •• • I I 11 ) J Severe COVID-19 i ••••• • ••• (Q) i ••••• •••• ..,.-.. ..,.-.. i ••••• • ••• ..,.-.. Fever, cough, fatigue, myalgia, dyspnea, death Septic shock, acute respiratory distress syndrome (ARDS), multiorgan failure, vasculitis, hypercoagulability, spleen and lymph node atrophy, disseminated intravascular coagulation (DIC), thrombosis, thrombocytopenia, extremities gangrene Quality Antibodies. Quality Results - Innate Immune Responses Against Corona virus Infection Extracellular Space ~q 6 MAVS Endocytosis .JJCCC«\. -------- dsRNA or / J -., ,phosphat ·e -sho ~ RNA DA-5 OAS RNaseL ~ RIM25 2-SA /. ,-- -- . i RIG-1 +-- RNAse~ ( RNaseL \ Degradation Products LRXl Cytoplasm ATP JV\h ssRNA / RAF3 .--- TA -· - NTBAD .______, NAP TANK .. -- NEMO -- TRAF2/5/6 .__----i TB K 1 Cytoplasm C]> IRF-7 ----- 00RF-7 · Apoptosis t IRAK-1 , ----+: . ----c Casp-8 IKKy/ NEMO l~ IKBa q?''i- : 7 ~\ JI , I (o .:f< : 1q ' Proteasomal Degradation .------ ~ MEKK-1 ,,__ MKK 3/6 TABl/2 MKK 4/7 l:,66½Y,,Mo66&,~,Moo6(,i,',6,:x,6o66661,)66c,Mob661,',6Mi'x,6o66/.',M6666<~'.Mi'J&Y:x'J6<xoo61)6(Ji,\66c,6664 00<"6M,Mob661,',6Mi'x,ooM/.',M6666<~'/JM/J&,i,\66c,6M6ool,)66c,666bojx'J6M666oMl.'J6M666<6661,)6,Y)66&,~ >666o&,i,"5.i ' t{Jlltioii : gt§]ffffffflffffllfjl, Nucleus Transcription Factor ·····• Translocation Phospho i;D Ubiquitin I IL-lRa, IL-1J3, IL-2R, IL-6, IL-7, IL-8, IL-9, IL-10, IL-18, M-CSF, G-CSF, GM-CSF, HGF, FGF, PDGF, VEGF, TNF-a, IFN-y, CXCR3, MCP-3, IP-10, MIGlA, LDH, D-dimer, procalcitonin, CRP, ferritin CD4+, cos+, NK cells, memory T cells, regulatory T cells IL-6, IL-1, IFN-a IFN-13, TNF GeneTex www.genetex.com Transcription Factors International Tel 886 .3.6208988 Fax 886 . 3.6208989 IL-1(3, IL-6, TNF-a, CCL2 Address 6F-2 , No.89, Dongmei Rd , Hsinchu 300, Taiwan ( R.O.C.) E-mail intemalional @genelex .com USA Toll-free 1.877.GeneTex (1. 877.436 .3839} Fax 1.949.309.2888 Address 2456 Allon Parkway, Irvine, CA 92606 USA E-mail info@genetex.com
Transcript of Innate Immune Responses Against Corona virus Infection...Title: SARS-CoV-2 (COVID-19) poster Author:...
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~ Fusion
Cell TMPRSS2
0 Translation Viral RNA
Polypeptide chains
0 Translation and RNA replication
0 Packaging
References
0 Virion release
Healthy
Pulmonary epithelium
co4+ T cell Circulation
• •
No symptoms
J Clin Invest. 2020 May 1; 130(5):2202-2205. Science 367(6485), 1412-14 13 (2020).
•
..,.-..
cos+ T cell
•
-
SARS-CoV-2 Virus Entry COVID-19
+E--=:;~ - RNA-dependent RNA polymerase
., ~ C ))
------------------------------..:r'"'--
Golgi Endoplasmic reticulum
I
I I
I I'
" ( /: 1'1 I i /! )) /
, di I I /
._ /II a,j l ,, I ,1/j"' !I I
I / / / I /1/ / / ( / • ; rl JI 1 1/ If ~ 1/,J//11//
I I I I I / I 1 \ I
Moderate COVID-19
Alveolar type II cells _& (ACE2 positive) ... SAR.oV-2
Macrophage and monocyte
i • TNF-a ••
IFN-y-expressing co4+ T cell
i • IL-6 ••
t Cytokine levels
• •
..,.-.. Fever, cough, fatigue, myalgia
I IL-6
Lymphocytes, co4+ T cells, cos+ T cells
i • IL-10 ••
•
I I 11 ) J
Severe COVID-19
i ••••• • •••
(Q)
i ••••• ••••
..,.-.. ..,.-..
i ••••• • •••
..,.-.. Fever, cough, fatigue, myalgia, dyspnea, death
Septic shock, acute respiratory distress syndrome (ARDS), multiorgan failure, vasculitis, hypercoagulability, spleen and lymph node atrophy, disseminated intravascular coagulation (DIC), thrombosis, thrombocytopenia, extremities gangrene
Quality Antibodies. Quality Results
-
Innate Immune Responses Against Corona virus Infection
Extracellular Space
~q 6
MAVS
Endocytosis
.JJCCC«\. --------~ dsRNA or / J -., ,phosphat·e-sho~ RNA
DA-5 ~ OAS
~ RNaseL
~p~ ~ RIM25 ~ ~ 2-SA
/. ,--- - . i RIG-1 +-- RNAse~ ( RNaseL\
Degradation ~ Products
LRXl
Cytoplasm
ATP
JV\h ssRNA
/ RAF3 .---TA -· - NTBAD .______, NAP
TANK .. --NEMO -- TRAF2/5/6 .__----i TB K 1
Cytoplasm
C]> IRF-7-----
00RF-7
· d&Hi:19►
Apoptosis
t IRAK-1 ,----+: .----c Casp-8
IKKy/ NEMO
~~
l~ IKBa q?''i-
: 7 ~\ JI , I (o .:f< : 1q ~
' Proteasomal Degradation
.------~ MEKK-1
,,__ MKK 3/6
TABl/2
MKK 4/7
l:,66½Y,,Mo66&,~,Moo6(,i,',6,:x,6o66661,)66c,Mob661,',6Mi'x,6o66/.',M6666<~'.Mi'J&Y:x'J6<xoo61)6(Ji,\66c,666400<"6M,Mob661,',6Mi'x,ooM/.',M6666<~'/JM/J&,i,\66c,6M6ool,)66c,666bojx'J6M666oMl.'J6M666<6661,)6,Y)66&,~ >666o&,i,"5.i ' t{Jlltioii : gt§]ffffffflffffllfjl, Nucleus
■ Transcription Factor ·····• Translocation ~ Phospho i;D Ubiquit in
I IL-lRa, IL-1J3, IL-2R, IL-6, IL-7, IL-8, IL-9, IL-10, IL-18, M-CSF, G-CSF, GM-CSF, HGF, FGF, PDGF, VEGF, TNF-a, IFN-y, CXCR3, MCP-3, IP-10, MIGlA, LDH, D-dimer, procalcitonin, CRP, ferritin
CD4+, cos+, NK cells, memory T cells, regulatory T cells
IL-6, IL-1, IFN-a
IFN-13, TNF
GeneTex www.genetex.com
◄ ► Transcription
Factors
International Tel 886 .3.6208988
Fax 886 .3.6208989
IL-1(3, IL-6, TNF-a, CCL2
Address 6F-2 , No.89, Dongmei Rd , Hsinchu 300 , Taiwan (R.O.C.)
E-mail [email protected]
USA Toll-free 1.877.GeneTex(1.877.436 .3839}
Fax 1.949.309.2888
Address 2456 Allon Parkway, Irv ine, CA 92606 USA
E-mail [email protected]
