Injectable Options as Add-Ons to Basal Insulin: Targeting PPG in Type 2 Diabetes Patients
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Transcript of Injectable Options as Add-Ons to Basal Insulin: Targeting PPG in Type 2 Diabetes Patients
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Injectable Options as Add-Ons to Basal Insulin: Targeting PPG
in Type 2 Diabetes Patients
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Program Goals
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The Incretin System: Response to Oral Glucose
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Injected Incretin-based Agents: GLP-1 Receptor Agonists
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Oral Incretin-based Agents: DPP-4 Inhibitors
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Main Pathophysiological Defects in T2D
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T2D Anti-Hyperglycemic Therapy: General Recommendations
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Approaches to Intensifying Therapy in Patients Not At Goal on Basal
Insulin
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Adding Prandial Insulin to Basal Insulin: Key Challenges
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Scientific Rationale for Combining Basal Insulin with a GLP-1 agonist
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DPP- 4 Inhibitors as Add-ons to Basal Insulin
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Pramlintide as Add-on to Basal Insulin
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Twice-daily Exenatide as Add-on to Basal Insulin (Glargine)
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Twice-daily Exenatide as Add-on to Basal Insulin (Glargine): Results
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Metformin plus Liraglutide Followed by Add-on of Basal
Insulin (Detemir)
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Metformin plus Liraglutide Followed by Add-on of Basal
Insulin (Detemir)
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Oral Agents Plus Basal Insulin (Glargine) Followed by Add-on Lixisenatide*
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Oral Agents Plus Basal Insulin (Glargine) Followed by Add-on Lixisenatide* (cont)
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Other Safety Concerns With GLP-1 Receptor Agonists
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Lixisenatide* vs Liraglutide: Effect on Postprandial Glucose Levels†
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Comparison of Basal Insulin + Lixisenatide* and Basal-Plus
Regimensa
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IDegLira* vs Degludec* or Liraglutide Alone: Effect on HbA1c
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IDegLira* vs Degludec* or Liraglutide Alone: Results
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Abbreviations
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Abbreviations (cont)
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References
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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References (cont)
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