Increasing Supply Chain Reliability Shifting...
Transcript of Increasing Supply Chain Reliability Shifting...
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Increasing Supply Chain Reliability – Shifting Paradigms
AFDO Conference June 22, 2015
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Xavier Health
Medical Device Industry
Pharmaceutical Industry
Cross-Industry Initiatives
• FDA/Xavier University MedCon Conference
• QARA Institute (professional development and certification)
• Support for CDRH “Case for Quality”
• FDA/Xavier University PharmaLink Conference
• Xavier/PwC Metrics Initiative
• Integrity of Supply
Good Supply Practices (GSP)
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Patient Safety
Save and improve lives
around the world
Help patients prevail over
serious diseases
We develop medicines that improve lives
around the world
To make a meaningful
difference to patient health
To help people do more, feel better,
live longer Everything we do must be of high quality
Improve the quality of life
for patients and caregivers
Product Failures
Warning Letters
Risks
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GMP GSP
GIP GDP
Increase Product
Confidence
With the End in Mind
GSP
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Governance Team
Helge Batz Director
Boston Scientific
Al Kentrup WW Director
P&G
Gwyn Murdoch Director Eli Lilly
Rafiqah Williams VP
Eli Lilly
Gretel Benavides VP
Perrigo
Mike King Director
J&J
Mark Paviglianiti Director Merck
Steve Wolfgang Acting Assoc. Director
CDER
Dale Carter Global Director
Huber
Michael Landberg Global Sourcing Boston Scientific
Marla Phillips Director
Xavier University
Steve Greer QA External Engagement
P&G
Hank Llamas VP J&J
Susan Rolih EVP
Meridian Bioscience
Dale Huff Exec. Director
Merck
David Lowndes SVP
Shire
Michelle Smith Sr. Director
Meridian Bioscience
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Integrity of Supply GSP
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Problem Statement
We are unable to reliably and consistently ensure the supply of incoming materials used in products to serve the Pharmaceutical and Medical Device
industries
Therefore, we need greater assurance that suppliers can reliably and consistently supply safe and quality materials/products to limit adverse impact on end-
user safety and brand equity
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Natural Tendencies
We are unable to reliably and consistently ensure the
supply of incoming materials
Our Suppliers are causing the
Problems
“If”
“Then obviously”
“So of course that means”
We need to “fix” our Suppliers
We need greater assurance that suppliers can reliably and
consistently supply safe and quality
materials/products
“and”
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Mission Statement
To determine the source of dysfunction affecting the
Integrity of Supply, and to implement sustainable
solutions that can be tied to Return on Investment -
such as increased safety, improved quality and
enhanced reliability – commensurate with the need.
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Integrity of Supply GSP
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Cause/Effect and Pareto
Product and Process Theme
1. We are not setting the right specifications to begin with
2. We rely on compendial testing rather than determine if other tests are needed for our product and process
3. We are not able to detect changes or deficiencies in in-coming material
4. We do not have a feedback loop for specification effectiveness
5. We do not have a robust change management system in place
6. We are not involved in setting the specifications beyond Tier 1
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Cause/Effect and Pareto
Supply chain Theme
1. We are unable to verify GMPs with a certain base of our suppliers
2. We have no real understanding of how the supply chain is managed beyond Tier 1
3. We do not have enough resources to monitor entire supply chain
4. We are not involved in selecting our supplier’s suppliers
5. We lack leverage with a certain base of our suppliers
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Cause/Effect and Pareto
Behaviors Theme
1. Our supplier approval process is not robust
2. We do not adequately share information with our suppliers
3. We do not engage cross-functional colleagues in the process, or not at the right time
4. We don’t follow our own supplier selection process
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Paradigm Shift
• August 2012: we wanted to focus on certifying our suppliers
• July 2013: top data is pointing to ourselves as the root cause
August
2012
July
2013
We are
Causing
Problems
“Our Suppliers
Are Causing
Problems”
Key Takeaway Disciplined process will focus on true root cause
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Action-Provoking!
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Integrity of Supply GSP
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Food Device Drug
58% 8%
17%
17% 30%
20% 20%
10%
20%
Business Development
Customer Service
Quality Operations/Assurance
Technical Operations
Other
9% 9%
59%
23%
Functional Background
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Food Device Drug
8% 12%
8%
16% 48%
8%
2%
19% 2%
36%
34%
7% 1%
15% 1%
24% 51%
8%
Africa Asia
Australia Europe
N. America S. America
Location of manufacturing facilities
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# of different “types” of products/materials
Food Device Drug
34%
8% 58%
41%
27%
32% 15%
33% 52%
<10 10-50 >50
# of different “types” of products/materials
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% of supplier’s product/material is specialty
Food Device Drug
17%
33% 17%
33% 19%
10%
14% 19%
38%
10%
10%
10%
9% 61%
<10 10-25 26-50
51-75 >75
% of supplier’s product/material is specialty
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Total Respondents
7% 14%
79%
Food
Drug
Device
Food Device Drug
12 128 22
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% of time willing to share process capability data and/or composition of material with customers
Food Device Drug
25%
8%
8%
59%
18%
9%
14%
9%
45%
5% 6% 4% 8%
13%
57%
12%
<10 10-25
26-50 51-75
>75 Not Sure
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% of customers who ask to see your process capability data and/or composition of material information
Food Device Drug
41%
17%
25%
17% 32%
9% 9%
18%
27%
5% 10%
16%
16%
19%
27%
12%
<10 10-25
26-50 51-75
>75 Not Sure
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% of customers ask for your input on specifications for your product/material
Food Device Drug
8% 8%
34% 8%
34%
8% 23%
27% 23%
4% 18%
5% 6%
13%
15%
27%
30%
9%
<10 10-25
26-50 51-75
>75 Not Sure
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% of time you have enough info about customer needs and process to know when it is important to report changes
Food Device Drug
8%
17%
42%
8%
25% 14% 9%
14%
9%
45%
9%
4% 5%
10%
16%
59%
6%
<10 10-25
26-50 51-75
>75 Not Sure
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% of time given access to representatives from your customers who have the responsibility, competency,
and authority to make decisions
Food Device Drug
8% 8%
25%
34%
25% 14%
9%
36% 9%
23%
9%
6% 10%
11%
27%
40%
6%
<10 10-25
26-50 51-75
>75 Not Sure
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Quality Agreement in place with what % of customers
Food Device Drug
25%
8%
17%
50% 27%
27% 23%
9%
14%
5%
13%
21%
17%
38%
6%
<10 10-25
26-50 51-75
>75 Not Sure
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% of customers who involve cross-functional representatives in the due diligence process
Food Device Drug
16%
25%
17% 17%
25% 14%
23%
18%
32%
9%
4% 5% 8%
19%
20%
34%
14%
<10 10-25
26-50 51-75
>75 Not Sure
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% of time changes in scheduling from your customer communicated w/ enough notice and with regard to the
commitments you have with other customers
Food Device Drug
33%
25%
25%
17%
9%
18%
14%
27%
9%
23%
8%
16%
25% 27%
17%
7%
<10 10-25
26-50 51-75
>75 Not Sure
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Paradigm Shift #2
• Suppliers = Customer: our specifications, requirements and expectations are the “products” we deliver to our suppliers
• Suppliers = Suppliers: the incoming material is the product we then receive from our suppliers
August
2012
July
2013
Suppliers
are
Customers First
Suppliers
are
Suppliers
Suppliers ≠ “Lesser” Entities
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Action-Provoking!
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Integrity of Supply GSP
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Good Supply Practices (GSPs)
Three over-arching themes
1. Product and Process Knowledge and Development
2. Supply Chain Development and Management
3. Driving Ideal Behaviors
End Goal
Development and implementation of pragmatic Good Supply
Practices (GSPs) related to the three over-arching themes that
include standardized practices based on cross-industry best
practices
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Anchor to SCM Process
Group GSPs under Supply Chain Management Phases
Link to process-specific
steps
Planning Implementation Lifecycle
Management
Requirements
and Risk
Supplier
Identification Qualification
Monitor/
Feedback
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Matrix of Input
Team
Planning Implementation Lifecycle
Management
Requirements
and Risk
Supplier
Identification Qualification Monitor/
Feedback
Product and
Process
Supply
Chain
Ideal
Behaviors
Marla
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Product and Process Group
Product and Process Knowledge and Development First Last Title Company
Christopher Claeboe Product Manager Albemarle
Matthew Deacon Director - API Manufacturing Eli Lilly
Elaine Jai Supply Chain and Procurement Eli Lilly
Siek Meng Khor QA Director Teleflex
Viliam Kovac Head of Global Compliance Roche
Glenn Muldoon Manager, materials procurement Shire
Mike Oleksa Senior Director Steris
Stelios Tsinontides Sr. Director, Mfg. Sci & Technology Shire
Sherry Warren President WLS Enterprises
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Supply Chain Group
Supply Chain Development and Management First Last Title Company
M. Bhupathy Senior Director Shire
Hanna Edstrom-Valsinger Sourcing Process Leader GE Healthcare
Paul Nelson Exec. Dir., Supply Chain Auxilium
Shonte Pettiford Quality Program Manager Abbott
David Rothenberger Consultant - QA Procurement Eli Lilly
Gerard Sheehan Quality/ Regulatory Affairs Director Tornier
Jack Solomon Practice Leader, Supply Chain Core Risks Ltd
Ken Stopar Director Supplier Quality Baxter
Andre Warren Vice President WLS Enterprises
Jean Pierre Zajac General Mgr., Sourcing EMEA GE Healthcare
Don Zgoda CQA Supplier Quality Management P&G
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Ideal Behaviors Group
Driving Ideal Behaviors First Last Title Company
Dave Gault Sr. Manager Risk, Compliance & Security CPKelco
Harry Gill Vice President Patheon
Christine Gladwell Quality Director - Global Supply Chain Baxter
Patrick Henry Director of Business Development Puritan Products
Tim Johnson Sr. Director, Quality J&J
Stephanie Leonardos President & CEO Amerikam
Diana Lewis Senior Specialist – Quality Merck
Ben Locwin Director Biogen Idec
Kristen Lyons Quality Engineer Cook
Geert Van Acker VP of Purchasing Baxter
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Swim Lanes
R&D Quality Supply Chain
Reg Affairs Suppliers
Step 1. Internal Risk Based Assessment
Step 2. Development of Product and Process
Step 3. Finalization of Requirements
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Action Provoking!
Increased Product Confidence
• Understanding our Product/Process
• Developing our Supply Chain
• Establishing Ideal Behaviors
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Action Provoking!
Transparency actually builds
trust, inspires creative problem
solving, and engenders
ownership of outcomes
Accurate forecasting and
harmonizing (“I’ll take a #1”)
reduces risk of error
![Page 42: Increasing Supply Chain Reliability Shifting Paradigmsindy.afdo.org/uploads/1/5/9/4/15948626/ddc-1115-phillips-supply.pdf1. Product and Process Knowledge and Development 2. Supply](https://reader033.fdocuments.in/reader033/viewer/2022060307/5f09c6537e708231d428709e/html5/thumbnails/42.jpg)
Action Provoking!
Supplier Qualification
Self Qualification
Capacity, Location, Risk of Material
Compliance, History
Compliance, Resources,
Stability, Product Knowledge
Forecasting Ability, Internal Alignment
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Specification
Bid Clarification
Purchase Order / Contract Docs
Communications
Manufacturing/Service Supprt
Quality Control
Change Control
Documentation
Delivery
Commercial Management
Interfaces with Client Systems
Post Delivery Experience
Co-operation & Relationships
Tender Process
650
670
650
672
623
261
692
590
594
630
629
300
220
614
25
25
18
20
16
12
24
25
25
23
21
14
12
18
Mediocre 2 4 6 8 10 Poor Adequate Good Excellent
KEY:
Maximum
score within
group
Purchaser
position within
group
Average score
of group
Minimum score
within group
Suppliers Rate Clients
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GMP GSP
GIP GDP
Increase Product
Confidence
With the End in Mind
GSP