Studying the international way

IMC University of Applied Sciences Krems, Austria

Bernhard Klausgraber

The University of

Applied Sciences Krems

Guiding Principles

We are an Austrian university with an international focus. We offer practice-oriented degree programmes according to the needs of the industry which fulfil international university standards.

Location – close to Vienna

2 venues in Krems:

International Campus Piaristengasse

Campus Krems

Around 1.800 students

Around 2.500 graduates

KREMS

Three Schools

School of Business

School of Health

School of Life Sciences

School of Life Sciences

Bachelor & Master programmes (in English)

Medical & Pharmaceutical Biotechnology

(BSc und MSc)

Regulatory Affairs (MSc)

Universities:

Danube Univ. Krems

BOKU Vienna

Med. University of Vienna

University of Technology

Vienna University of Economics

University of Linz

University of Rostock

University of Greifswald

University of Augusta

University of Boston

Universities of Applied Sciences:

FH Tulln

FH Hagenberg

FH Lübeck

FH Biberach

Rentselear Polytechnic Institute Troy

Research Centers:

FZ Karlsruhe

Czech Acad. Sc. Nove Hrady

Fraunhofer Institute Leipzig

Ludwig Boltzmann Institute Wien

Clinics:

AKH Vienna

Hospital Tulln

European Patent Office

Munich

Nat. & internat. Lecturers

Companies: Topics:

Sanofi/Aventis, Vienna => Drug Law

Baxter Bioscience, Vienna => Project Management

Boehringer Ingelheim, Vienna => Quality Management

Fresenius Medical Care, B. Homburg => Scientific Marketing

Membrana, Wuppertal => Spec. Material Science

Miltenyi, Teterow => Pharm. Expression

Octapharma, Wien => Pharm. Production

Pfizer, Wien => Medical Products

Roche, Basel => Pharma. Marketing

Sandoz/Novartis, Kundl => Pharma. Production

ViruSure GmbH => Quality Management

Technology Companies:

ArsArthro GmbH, Krems => Medical Biotechnol.

ARWIG GmbH, Vienna => Biostatistics

Biotec Systems GmbH, Krems => Adsorber Technologies

InterCell GmbH, Vienna => Patent Law

DOT GmbH, Rostock => Implant Material Science

Rational GmbH, Rostock => Process Technology

WSB GmbH, Krems => Material Science

Ministry and Agencies => Clinical Studies

=> GMP / GCP

Lecturers from LifeScience Companies

9

Biotechnology at IMC stands for a balanced practical orientation

• The balanced interdisciplinary study program covers the whole „Value Chain“ from R&D to the approval of new drugs or medical products

• The methodical orientation and problem-solving abilities as first educational principle

• A full-time lecturer team with significant practical experiences – International education :

Austria => Med Univ. Vienna, Univ. Salzburg

Germany => Univ. Rostock

Slovakia => Univ. Bratislava

GB => Strathclyde Univ. Glasgow

USA => Cornell Univ. Medical Scholl, New York

Japan => Jikei Univ, Tokyo

- International research projects:

Germany => Zeiss Jena, Fresenius Homburg

USA => Beckman, PenKem New York

Japan => JMS Hiroshima

- International networking

Scandinavia => EU – Life Science Region

EC-Projects => Assessment procedure for innovative start-ups

-

• Broad and practical orientation

• Teaching contents based on a survey including the

pharmaceutical industry

• Balanced program between biomedicine and technology covers

the whole “value chain” from R&D up to approval of new drugs or

medical product

• High percentage of quality elements incorporated in lectures and

various laboratory course

• Methodical orientation and problem-solving abilities as first

educational ....

• Modular design of the study program

• Flexibility for participation in international joint programs

Our concept stands out against the classical (biotechnology) education

11

Bachelor program: 6 Semesters

Focus on basic knowledge to understand complex processes and

training of practical skills in:

• Basic Bio-Sciences

Biophysics, Mathematics, Chemistry, Biochemistry, Microbiology, Physiology, Diseases, Genetics, Pharmacology, Bioinformatics, Physiology, Medicine

• Special Laboratory Techniques

Cell Culture, Genetic Engineering, Fermentation,

Instrumental Analytics, Clean Room Training

• Quality Management

Project Management, GLP, GMP, GCP, Industrial Hygiene

• Bioprocess Technologies

Bioengineering, Pharmaceutical Production Systems

• Practical Training 8 months (mostly abroad)

12

Specialisation in:

• Pharmaceutical Production Technologies

Recombinant Protein Production, Fermentation, Bioseparation,

Quality Management and Validation

• Medical Biotechnology / Regenerative Medicine

Tissue Engineering, Cancer, Aging, Artificial Organs,

Nanobiotechnology

• Management

Business Administration, Quality and Project M., Regulatory

Affairs, Patenting, Licensing, Marketing

• Research Semester in Universities and Industry in 25 countries

Master program: 4 Semesters

13

International … ?!

International students

International Visiting Professors and guest lecturers

60 % of students for bachelor/master thesis abroad

9. International Life Science Meeting of IMC FH Krems

EC-project Interreg

EC-IP-Course

ESAO Summer School „Biomaterials and Regenerative Medicine“

Lectures, posters and chairmanship at international conferences

Prof. Ivar Giaever, USA Nobel Prize in 1973

together with Esaki and Josephson

“Electron Tunneling”

Lecturer at FH Krems

Keratinozyten

Fibrinmatrix

Fibroblasten und/oder

Endothelzellen

Richtung der Migration

Elektrode

e.g.

Wound Healing Assay

Giaever´s Company:

R&D Profil of the Inst. Biotechnology New cell-based technologies for testing of bioactive substances Coop with Industry, Universities, EU 3.6 Mio. Project volume

16

• Current projects

• Students in research

• Scientific work

• Publications

• Conferences

• Cooperations

Our Research Concept:

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Our Research Concept:

1. Development of unique methods and technologies

2. Cooperation with partners:

Application research and service

Development of new methods

Participation in life science programms

3. Use of methods and technologies in education

4. Partner in international scientific networks

5. Foundation of start-up company or research center

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Research Focus Medical Biotechnology:

1. Drug Discovery and Therapeutic

Strategies in Cancer, Inflammation and Regenerative

Medicine

2. Bioprocess Technology

Our Research Concept:

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Cancer Research

Cell Biology

Tissue

Regeneration

Instrument Development

Core Competences of Group Leaders

Innovative Assay Development

Biochemistry

Regenerative

Medicine

Drug Discovery

Our Research Concept

20 20

Potential for Synergy: Cooperation between the working teams

Drug Discovery

Tissue Engineering

Cell-based Testsystems

Ultimate Goal: Development of Lead

Compounds, Therapeutics and Diagnostics

Novel experimental methods

Our Research Concept

Our Research Concept

Target

Identification

Target Validation

Lead Identification

Lead Optimization

Phases of the drug

discovery process:

Preclinical and

Clinical

development

Organotypic Tumor Models in the Drug Discovery Process

Non-invasive assay

development to detect drug

induced reversions of the

hallmarks of cancer

- Inhibition of Proliferation

- Induction of Apoptosis

- Induction of Senescence

- Induction of Differentiation

- Inhibition of Invasion

Signaling Pathway Analysis

Genotype-Drug Response

Analysis

RNAi based Screening Techniques

Phenotype Based Drug Discovery

MDA-MB-231 MDA-MB-415 MDA-MB-468 MCF7 ZR-75-1

2D

Spheroids

Breast Cancer Cells

Dendritic Cell Based Cancer Therapy

Dendritic Cell Based Cancer Therapy

Personalized Medicine in Cancer

Screening of Marine Substances

Hanging Drop Rotory Wall Vessel

Establishment of 3D Tumor-Speroids

30µg

0 h 24 h 48 h 120

h

n.c.

3mg

30µg

Screening of marine Substances

Cultivation of

marine Organisms Pre-Screening of marine

Substances 2D Assays

rela

tive

flu

ore

sce

nce

0

0,2

0,4

0,6

0,8

1

1,2

Isolation of bioactive

Substances

Tumor-Immuntherapy

29

-downregulationof cbl b silencing

-isolation ofwhite blood

cells

-injection of activated cells

Establishment of organotypic 3D Tumor Sphäroids in vitro

32

Drug Discovery Systems

• Drug screening methods

Tumor models

Inflammation models

• Cooperation with Industrial Partners

Development of a new detection platform techniques

=> Support of scientific marketing world-wide

33

Pharmaceutical Process Technology

• Fermentation optimization

Oxygen Transfer

Calculation models

Index numbers

• Cooperation with Industrial Partners

=> Development of new production technologies

Presentation of first results in San Diego

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Biotechnology at IMC Krems

• The balanced program covers the whole „Value Chain“ from R&D to the approval of new drugs or medical products

• Methodical orientation and problem-solving abilities as first educational principle

• Lecturer team with experience in international education and research projects

• International networks with Life Science industry and universities

=> The graduates starting their career in:

Industrial R&D 40%

Institutions 20%

PhD-programs 40% (Harvard, Cambridge, London, Oxford, Singapore, Hongkong, Antwerpen, Hannover, Aachen, Gent, Vienna, Graz, Innsbruck, Dublin, Stockholm, ..…)

Krems´s Specials in Numbers

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Nat & International Practical Training

Further PhD – Studies

Jobs

Acambis Cambridge, USA AGES, Wien Austrian Academy of Sciences, Wien Baxter Bioscience, Wien Baxter International, USA Biomin, Österreich Boehringer Ingelheim, Wien Chemistry School of Pharmacy, AUS Danube University, Krems Hagedorn Research Institute, DK ICRM Montreal, Kanada IMC, Krems LCT, Australia LKH Klagenfurt, Klagenfurt LMU München, Tansania/Deutschland McMaster University, Kanada Morphosys, Deutschland Octapharma, Wien Sandoz, Tirol Bundeskriminalamt, St.Pölten Vaxine Pty. Ltd. Sydney, Australia Tissue Genesis Inc., Hawai

National Laboratory of Berkeley

Sanquin Research, Niederlande

University of Alabama

University of Antwerp

University of British Columbia Vancouver

University of Brussels

University of Groningen

University of Homburg

University of Melbourne

University of Okago

University of Pecs

University of Queensland

University of Sidney

UTSW Medical Centre Dallas

Cancer Cell Inst., Madrid

University of London

University of Oxford

Univeristy of Cambridge

University of Sussex

University of Singapore

University of Hongkong

New York University

Pratical Training Semester BA and Applied Research Training Semester MA

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Practical Training Semester BA and Applied Research Training Semester MA

Since 2005: 358 Students in 25 countries

65% abroad

Universities 187

Industry 87

SMEs 31

Research Centers 29

Gov. Offices 10

IMC Krems 14

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Practical Training Semester BA and MA: Cooperation world-wide

Europe: 104 Germany 32

Great Britain 19

Netherlands 9

Sweden 8

Ireland 7 ….

Australia, New Z. 46 Australia 41

New Zealand 5

Amerika 40 USA 30

Canada 10

Asia 6 Singapore 4

Hongkong 1

Shanghai 1

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Pratical Training Semester: Cooperation in Austria

Industry 47 Baxter 21

Boehringer 16

Octapharma 4

Universities 44 MedUni

Graz

Innsbruck

Salzburg

VetMed

SMEs 28

Research Centers 18

AGES 7

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Pratical Training Semester: Cooperation in Lower Austria

Industry 35 Baxter

SMEs 22 SeaLife Pharma 8

Biomin 5

Cell Danube 5

TMB 3

Arthro Kinetics 1

Danube University 13

IMC FH Krems 14

The intensive personal interaction of our IMC team with the external coaches worldwide shows a positive feedback about:

=> Performance of our students regarding:

structured problem solving abilities

open mind for interdisciplinary projects

flexibility

engagement

team work and management abilities

=> Possible further improvement of our educational concept

Bologna process

=> Use of our students activities for the establishment of new cooperation for research projects

=> Presentations of thesis at international conferences by the graduates

many of our students are invited to give talks at international conference or

are authors of peer-reviewed articles

The positive outcome of international practical training

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Jobs of our Graduates (Known to us)

from this in Lower Austria:

Industry 57 19

SMEs 13 5

Universitys 40 6

Gov. Offices 4

from this in PhD-program:

42

Additional Studies: 5

(Medicine, Pharmacology, Diplomacy,…)

43

Further PhD Studies in:

Austria: Med. Univ. Vienna 8

Techn. Univ. Vienna 4

Univ. Vienna 1

Univ. Graz 3

Univ. Salzburg 1

Med. Univ. Innsbruck 2

BOKU Vienna 2

USA: Boston Univ. 1

Univ. Honolulu 1

Great Britain: Univ. London 1

Royal Institution 1

Univ. Cambridge 2

Univ. Oxford 2

Kings College London 2

Belgium: Univ. Gent 1

Univ. Antwerp 1

Ireland: Univ. Dublin 3

Germany : Univ. Hannover 1

Univ. Leipzig 1

Univ. Munich 1

Univ. Kassel 1

Univ. Aachen 1

Justus Liebig Univ. Giessen 1

China: Univ. Fudan, Shanghai 1

Univ. Hongkong 1

Sweden: Karolinska Institute 1

• Strong educational program

• Preparation for interdisciplinary projects in research and industry

• Team with strong experiences in education and research

• Interesting research profile: financial support (actual 3.5 Mio. €)

• Incorporation of representatives from industry and universities teaching newest

developments in biomedicine and biotechnology

• Close personal relation with industry, research institutions and universities

worldwide brings on a vast variety for the preparation of the practical training

semester

• Until today, our biotechnology students successfully finished their 9- months-

training in more than 25 countries, e.g.:

Universities: Harvard, Cambridge, Antwerp, Dallas, Lund

Leipzig, Singapore, Honking, Sydney

Industry Europa, America, Asia, Australia, Africa

• No unemployed graduates, 40% in PhD-programs world-wide

Attraction for students with clear and dedicated minds: A Summary !