Imaging of bone erosion in Rheumatoid...
Transcript of Imaging of bone erosion in Rheumatoid...
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Imaging of Hand in Rheumatoid Arthritis with
CR, US and MRI
Azar Bahrami, PGY4Radiology Rounds
Jan, 31, 2007
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Introduction
RA most common type of inflammatory Arthritis with prevalence of 1%Accurate and early diagnosis of RA and erosive joint damage is imperativeEarly and aggressive treatment is effective in patients with active diseaseIt reduces functional deterioration and improves long term outcome
Jones G, Rheumatology (Oxford), 2003; 42: 6-13
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Introduction
It should be implemented before irreversible damage and functional deterioration occurImaging techniques useful for selecting pts that benefit the most from early aggressive therapy as well as assessing response to treatment with DMADR’S
Jones G, Rheumatology (Oxford), 2003; 42: 6-13
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EULAR Guidelines: Mx of early arthritis
Combe B, Ann Rheum Dis, 2007; 66: 34-45
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EULAR Guidelines: Mx of early arthritis
Combe B, Ann Rheum Dis, 2007; 66: 34-45
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Radiographic progression
Early radiographic evidence of erosions independently predict long term radiographic progressionThe number of swollen joints probably correlates better with radiographic progression than the number of tender jointsAnti CCP Ab is also an independent prognostic factor for Rad progression in early RA
Visser H, A&R, 2002; 46: 357-65
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Radiography
Conventional radiograph is the traditional imaging method used to diagnose, stage and monitor disease progression and treatment response in RAEarliest and most frequent involved joints in RA, wrist, MCP, PIPReview alternative imaging modalities: MRI, CT, US, Scintigraphy
Guermazi A, Semi in muskolskel Radiol, 2004; 8
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Radiography
Radiographic lucency associated with bone erosion caused by primarily by loss of cortical bone rather than trabecular boneRadiographs are relatively insensitive to trabecular bone loss and therefore to intra-medulary component of bone erosionRadiography is a projectional technique, superposition of overlapping structure can obscure erosion
Conaghan PG, A&R, 2002;46:1971
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Radiography
Guermazi, Semin in Muskskelt Radiol, 2004; 8
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Guermazi, A, Sem in Muskskel Radiol, 2004;8
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Peterfy CG, Semin Arth Rheum, 2001; 30: 375
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Superimposition
McQueen, F, Ann Rheum Dis, 2001; 60: 859
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Repair phenomenon
Radiographic featuresSclerosis, cortication, filling in of erosions, remodeling and restoration to normal shapeNote: sclerotic margin on preexisting erosion suggest repair and new bone erosion suggests progression.
Indicates the efficacy of treatmentDifficult to interpretDifficult to detect repair phenomenon in trials with longstanding destructive change
Sharp, JT, J Rheumatol, 2003;30:1102
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Repair
Sharp JT, J Rheumatol, 2003; 30: 1102
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Ultrasound
Guermazi A, Semin in Muskoskel Radiol, 2004;8
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Wakefeild J, A&R, 2000; 43: 2762
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US: Erosions
Keen H, Rheum Dis Clin N Am, 2005; 699
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Ultrasound vs. CR
More sensitive than CR in detecting bone erosion at MCP, PIP, wrist and MTP, especially in early disease1
Greater sensitivity for 2nd, 5th MCP, 5th MTP2
Accessibility with US probeEarly involvement
Higher level of reproducibility Detects synovitis and tenosynovitis
1.Weidekamm C, A&R; 2003; 48: 325 2.Alarcon GS, A&R, 2002; 46: 1969
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CR vs. US: Erosions
Alarcon GS, A&R, 2002; 46: 1969
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Wakefield J, A&R, 2000;43:2762
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US vs. MRI: Erosions
MRI and MUS detection of bone erosions consistent1
Conflicting results as to which is more sensitive
MRI more sensitive at MCP joints 1
US detected more erosion than MRI at MCP and equal at the wrist 2
1.Hoving J, J Rheumalol, 2004; 31: 663 2.Magnani M, Clin Exp Rheum, 2004: 22: 743
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MRI vs. US: Erosions
Wakefield R, A&R, 2000; 43: 2762
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Color doppler US
Synovial vascularity and inflammatory activityCorrelates well with clinical disease activityCorrelates well with early synovialenhancement on dynamic MRI in the MCP joints1
Szkudlarek M, A&R, 2001; 44: 2018
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US: Synovial hypertrophyUS more useful than MRI in detecting joint and tendon sheath effusion1
Hoving J, J Rheum, 2004;31:663
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US: Tenosynovitis
Keen, Rheu Dis Clin N Am, 2005; 669-714
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CT scan
CT scan is superior to CR and inferior to MRI and US in detecting small erosions
1. Ostergaard M, Scan J Rheumatol, 2003; 32: 63 2. Alasaarela E, Br J Rheum, 1998; 37: 1152
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CT vs CR
Guermazi A, Semin in Muskolsk Radiol, 2004; 8
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CT vs CR
Guermazi A, Semin in Musculoskelet Radiol, 2004; 8: 269
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MRI
Guermazi A, Semin INMuskolskel Radiol, 2004; 8
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MRI
Detects erosion, BM edema, synovitis and tenosynovitis early in the disease.Erosion detected in high proportion of RA pts (45%) very early on (4 m) when CR is frequently normal (85%)1
MRI of wrist with first presentation of RA can predict radiographic erosions at 2 years 2
1.McQueen F, Ann Rheum Dis; 1998; 57: 350 2.McQueen F, Ann Rheum Dis; 2001: 60:859
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MRI
Bone marrow edema, not visualized on CR, is a pre-erosive sign of arthritic bone damage and may have prognostic value in early RA1
Differentiates well circumscribed bone erosion from ill defined areas of pre-erosive BME
Hypointensity on T1 and hyperintensity on T2 and fat suppression and gad enhancement
The most common site of BME on the wrist are lunate, capitate and triquetrum2
1.McQueen F, Ann Rheum Dis, 1998; 57: 350 2.Pterfy C, J Rheum, 2001; 28: 1134
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MRI: BME predicts erosion
Peterfy CG, Semin Arth Rheum, 2001, vol 30, 375
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McQueen F, A&R, 2003; 48:1814
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Farrant M, Skel Radiol, 2006;
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MRI: BME and Synovitis
Farrant M, Skel Radiol, 2006
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MRI: Synovitis
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Scintigraphy
Ostergaard M, Scand J Rheum, 1995; 24: 212
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Scintigraphy
Scintigraphy detects inflammation and bone turnover at site of active erosionSignificant correlation between pathologic finding on 3-phase bone scintigraphy and finding on physical exam and US, but not on MRI and CRScintigraphy is very sensitive, but not specific for synovitis and bone erosion in RA
Grassy W, Ann Rheum Disease, 2001; 60:98
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SummaryMRI shows the greatest sensitivity
Detecting and monitoring bone erosionPre erosive features of RA: BM edema, synovitis and tenosynovitis
Ultrasound more sensitive for erosions than radiograph and evaluation of synovitis
Operator dependency, restricted anatomical coverage are practical limitation to its use
Scintigraphy is very sensitive, but not specific for synovitis and bone erosion in RAConventional radiography is less sensitive for bone erosion especially in early stage
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References
Combe B, Ann Rheum Dis, 2007; 66: 34-45Guermazi A, Semin in Muskolskel Radiol, 2004; 8: Keen H, Rheum Dis Clin N Am, 2005: 699-714Rev Farrant A, Skel Radiol, 2006 part 1Rev Farrant A, Skel Radiol, 2006 part 2Hoving JL, J Rheumatol, 2004; 31: 663Szkudlarek M, A&R, 2004; 50: 2103Jones G, Rheumatology (Oxford), 2003; 42: 6-13Alarcon GS, A&R, 2002; 46: 1969McQueen FM, Ann Rheum Dis, 2001; 60: 859Wakefield R, A&R, 2000;43: 2762