iGEM The Registry of Standard Biological Parts · • Registration May 1st ($1000 team registration...
Transcript of iGEM The Registry of Standard Biological Parts · • Registration May 1st ($1000 team registration...
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iGEM&
The Registry of Standard Biological Parts
Randy RettbergRandy [email protected]
igemigem.org.org3/20083/2008
IBE North Carolina
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Grand Prize Winner: PekingFinalists: UC Berkeley, Ljubljana, Paris,
UCSF, USTC, PekingFoundational Research: Paris
Environment: GlasgowInformation Processing: Peking
Energy: AlbertaHealth & Medicine: Slovinia
Best BioBrick™ Part: Cambridge & MelbourneBest Foundational Technology: USTC
Best Model or Simulation: BangaloreBest Poster: UC Berkeley & Calgary
Best Presentation: ETHZ
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j p
Environment: Lead, Copper, Mercury, Cyanide, Phenolic-Cyclic, Extra Virgin Olive Oil
Structural: Vacuole in E.coli, Gas Vesicles, In Vitro Vesicles, MulCellular Bacterium, Bacterial Clumps
Computational: AND Gates, Schmidt Triggers, Level Detectors
Energy: Butanol, Bacterial Batteries, Efficiency
Infrastructure: Genomic Integration, Measured Parts, 819 New Parts
Systems: BactoBlood, AIDS Detection
Check iGEM.org for slides and videos of the presentations
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• Students• Making future synthetic biologists• Teaching entrepreneurial competition
• Instructors• Opportunities for junior faculty• New programs - new ideas• A task worth the effort
• Schools• Synthetic biology entering curriculum• Energize research programs
• Synthetic Biology• Examples, parts, successes, testimonials
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2003
2004
2005
2006
2007
2008
2009
4
5
13
32
54
90?
145?
20
70
~120
360
570
950?
1550?
20
70
150
400
750
1200?
2000?
Year Teams Jamboree Total
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Can simple biological systems be built from standard, interchangable parts and operated in living cells?
- YES, SOMETIMES
Or, is biology so complex that each case is unique?
- NOT ALWAYS
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• Synthetic Biology based on standard parts• Kit of Parts from the Registry• Team formation and preparation in the spring• Registration May 1st ($1000 team registration fee)• Students select their own project• Teams of 8 to 12 (or more) undergraduates and 2 (or
more) instructors work at their schools during their summer
• Registry materials available through the summer• Teachers workshop in May/June• Teams presents at the Jamboree at MIT in November• Awards and fun
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iGEM 2007 (Small Sample)$20K 8$30K 8$40K 1$50K 4>$50K 2
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• Tools for synthetic biology based on standard parts
• Information in the Registry will be available through XML and other standards
• Tools to be designed and built by iGEM teams same rules
• Tools must be open source and be made available to the synthetic biology community on our systems
• May limit the number of teams and require proposals
• Goal - impress us
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An industry based on standard parts requires catalogues and suppliers of those parts.
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http://parts.mit.edu
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• Promoters
• Protein Coding
• Reporters
• RNA
• Terminators
• Signaling
• Many project parts
2000 Parts Available as DNA(Includes 819 from iGEM 2007)
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Chris Anderson’s Constitutive Promoters
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Syn-Bio-Co 1 Syn-Bio-Co 2 Public Data School 1 Lab 1
ToolTool
Tool Tool
ToolViewer
erViewer
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p
urposes:Promote scientific engineering education througdesign competitions in biology.Promote the development of Synthetic Biology iEurope.
eu.igem.org (soon)
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1. Technical StandardsAssemblyMeasurementComputer interchange
2. Legal StandardsOpen biological partsSafety and responsibility
Join the BioBricks™ Foundation at biobricks.org
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• Apply for a job at the Registry(or tell a friend)
• Organize a team for 2008igem.org/2008 for mailing lists
• Have your lab join the Registry• Contribute parts to the Registry• Use BioBrick™ part standards• Help raise money for teams in your area• Join iGEM committees (see the wiki)• Join iGEM in Europe• Sign up for iGEM news (igem.org/2008)
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At the Registry - iGEM Central
• Meagan Lizarazo• Mackenzie Cowell• Scott Mohr• Tom Knight• Randy Rettberg
Advisors• Drew Endy• Malcolm Campbell• Gerald Sussman
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• National Science Foundation
• SynBERC
• CSBi
• GENEART
• The MathWorks
• Microsoft Research
• Biological Engineering - MIT
• febit