iGEM and The Registry

Synthetic Biology Genopole Randy Rettberg, Dec. 16, 2010

iGEM Schedule: Assemble Your Team

5 High School Students5 Undergraduate Students3 Graduate Students3 Faculty

Utah State - iGEM 2009

iGEM Schedule: Raise Money

iGEM Schedule: Attend A Workshop

iGEM Schedule: Get the BioBrick Parts

iGEM Schedule: Work At Your School

iGEM Schedule: Attend the Jamboree

iGEM Schedule: Attend the Jamboree

iGEM Schedule: Win Awards

Creating a Red Blood Cell Substitute

ResearchersArthur Yu • Austin Day • David Tulga • Hannah Cole • Kristin Doan • Kristin Fuller • Nhu Nguyen • Samantha Liang • Vaibhavi Umesh • Vincent Parker

Teaching AssistantsAmin Hajimorad • Farnaz Nowroozi • Rickey Bonds

AdvisorsJohn Dueber • Christopher Anderson • Adam Arkin • Jay Keasling

Medical Applications

UC Berkeley iGEM 2007

Save the World - Arsenic Detector

A test tube could contain all the necessarycomponents: Freeze dried bacteria, growth

medium,indicator powder, Ampicillin salt, etc…•These tubes could then be

given to local villagers to monitor their own water quality themselves

•A good alternative to the widely used Gutzeit method

www.Macteria.co.uk

Live Forever - BioBeer - Resveratrol

2009 Winner - Cambridge

Is iGEM Safe?

Is iGEM Secure?

iGEM Sites

Europe Almost Always Wins

20102009 2008 2007 2006

Slovenia Cambridge Slovenia Peking Slovenia

BCCS-Bristol Freiburg Caltech UC Berkeley Imperial

Cambridge Groningen NYMU Taipei Slovenia Princeton

Imperial Heidelberg Freiburg Paris

Peking Imperial HarvardUC San

Francisco

TUDelft Valencia UC Berkeley USTC China

Community Parts Collection

Registry DNA Distribution

iGEM Philosophy

Get and Give

Teams are expected to use the parts, ideas, and experience of teams in previous years.

Teams are expected to contribute their parts, ideas, and experiences.

Community Beyond iGEM

iGEM Statistics

• 7,362 users• 2,975 users have logged in this year• 1,189 have entered parts• 118 labs registered

• 14,959 part entries in the Registry• 7,172 samples in the Repository• 2,924 parts reported to work• 1,837 samples sent by iGEM 2010 teams• 800 confirmed DNA (of 1000) in 2010

distribution

iGEM Growth and Scale

25% Growth Projected

Year Teams Attendance

IAP 4 20

2004 5 70

2005 13 130

2006 32 320

2007 54 540

2008 84 840

2009 112 1,120

2010 130 1,300

2011 165 1,650

2012 205 2,050

2013 250 2,500

2014 320 3,200

2015 400 4,000

04 05 06 07 08 09 10 11 12 13 14 15

Regional Structure 2011

World Championship

Jamboree

30 Judges

Asian Jamboree

30 Judges

Americas Jamboree

32 Judges

European Jamboree

30 Judges

The TTL Data Book

The Registry of Standard Biological Parts

Web of Registries

Peking

iGEM HeadquartersGenopole

SB CorpImperial

SynBERC

What we want

Syn-Bio-Co 1 Syn-Bio-Co 2 Public Data School 1 Lab 1

ToolTool

Tool Tool

ToolViewer

ViewerViewer

How can the interfaces be developed?

XML Part Output

Ajax-Based Editing

Device – A ‘Black Box’

Synthetic Biology Question

Can simple biological systems be built from standard, interchangeable parts and operated in living cells?

Or, is biology so complex that each case is unique?

Synthetic Biology Question

Can simple biological systems be built from standard, interchangeable parts and operated in living cells?

Sometimes !

Or, is biology so complex that each case is unique?

Not always!

iGEM and The RegistryQuestions?

Engineering Products –Apple Quadra 840AV

“Ahead of its time, the 840AV and its relative, the Centris/Quadra 660AV, were the first Macintoshes to include 16-bit 48KHz stereo audio recording capability, as well as S-Video and Composite video input and output. They were also the first personal computers that supported speech recognition (PlainTalk) out-of-the-box.”