1. Crete Meeting on Incubation - 12 September 2007

2. Where are we ?

• 8 Bioparks

• Over 150 biotech Cies - 4 000 jobs -

• 300 public and private research centers

• 324 pharma Cies - 32 257 jobs -

• 363 medical equipment Cies - 10 434 jobs -

• 90% of the French CRO

• The largest European hospital system

• - 41 state-run hospitals ( 25 000 beds) -

• Hot spot for clinical trials

30 Km Paris Region Bio-cluster Top 1 in EU for S&T - 7,5 % GDP devoted to R&D -

3. Genopole Entreprises

4.

• CREATE & EXPAND THE INDUSTRIAL BIOPARK

• Increase the number and competitiveness of biotech companies in Evry and the Paris Region by

• • - Creating and incubating new start-up companies

• • until market acceptance

• • - Attracting existing companies

• • - Supporting companies development

GE : OUR MISSION

5. 1998 : 4 companies (110 employees) 2006 : 62 companies ( 730 employees ) 160 Million raised among VCs 22 products in RPC & clinical trials 25 companies have total sales of 58 M GE : OUR ACHIEVEMENTS

6. 53% Biopharm a: 6% Bioinformatics Informatics 2% Chemistry 9% Others Sequencing 1,9% Therapeutic screening 3,7% Drug delivery 7,4% Diagnostics 14,8% Therapeutic research 25,9% From Idea to Market acceptance Cancer Infectious (HIV - HepC) Ophthalmology Metabolics disorders Autoimmune Others PII-b PII-III Orphan drug GE : GENOPOLE COMPANIES 17% Material Device 13% Agri Biotech Environment

7. GE : OUR OBJECTIVES 2010 100 companies ( 2 500 employees ) 5 to 10 success stories (IPOs, M&A, Sales) Products on the market Attract Big Pharma companies

8.

• An expert committee with academic and industrial members (15) in charge of selecting projects

• G1J - Genopole pre-seed Capital Fund

• Investment / project : 50 000 100 000 , bringing a first entrepreneurial dimension

• A Team of 6 multidisciplinary Project Managers + Network of experts

OUR RESOURCES

9. A Comprehensive set of facilities (80 000 m) ranging from: - A simple office for the creator (20 to 50 m) - A specific biotech greenhouse (50 to 400 m) - Larger facilities (500 to 2000+ m ) OUR RESOURCES

10. OPERATIONALS FIELDS Crete meeting on Incubation Creation of value Duration Traditional incubation / 24 months From First day to First Round

11. Duration Interaction with Tech Transfer Office Grants POC/Market Think about scale-up Creation of value OPERATIONALS FIELDS

12. Duration Creation of value - Access to specific skills and expertise : - Business Development - Clinical Development - Regulatory Affairs - Scale-up OPERATIONALS FIELDS

13. Duration OPERATIONALS FIELDS Creation of value

14. Finance Science(s) Market Compet. IP Clinique&Reg Scale up 6 4 2 0 Team Bus Dev OPERATIONALS FIELDS