Ian S. Haworth, Ph.D.

Date of Birth: 8th June, 1962, Blackpool, EnglandCitizenship: United Kingdom

(U.S. Permanent Resident)Work Address:Department of Pharmacology & Pharmaceutical SciencesUniversity of Southern California1985 Zonal AvenueLos Angeles, CA 90089-9121

tel. (323) 442-3310fax. (323) 442-1390e-mail: ihaworth@usc.eduhttps://ihlab.hsc.usc.edu

Education / Professional Experience

1992- Department of Pharmacology & Pharmaceutical Sciences, University of Southern CaliforniaAssociate Professor of Pharmaceutical Sciences, 1998-Assistant Professor of Pharmaceutical Sciences, 1992-1998

1989-1992 Physical Chemistry Laboratory, Oxford University, Oxford, EnglandPostdoctoral Research funded by the National Foundation for Cancer Research 'Computer Modelling of the Structure and Dynamics of DNA'advisor: Dr. W. Graham Richards.

1986-1989 Department of Chemistry, University of Liverpool, Liverpool, EnglandPh.D. in Physical Organic Chemistry. S.E.R.C. / C.A.S.E. award with I.C.I. (Advanced Materials) 'N.M.R. and Computer Modelling of Polymer Structure'advisor: Prof. Raymond J. Abraham.

1982-1985 Department of Chemistry, Manchester Polytechnic, Manchester, England.GRSC / B.Sc. 2.1 (Chemistry).

Peer-Reviewed Publications

(91) Ratnatilaka Na Bhuket P, El-Magboub A, Haworth IS, Rojsitthisak P. Enhancement of curcumin bioavailability via the prodrug approach: challenges and prospects. Eur J Drug Metab Pharmacokinet 2016 Sep 28. [Epub ahead of print]

(90) Tangprasertchai NS, Zhang X, Ding Y, Tham K, Langen R, Rohs R, Haworth IS, Qin PZ. Integrated spin-labeling/computational-modeling approaches for mapping global structures of nucleic acids. Methods Enzymol 2015;564:427-453.

(89) Ambroso MR, Haworth IS, Langen R. Structural characterization of membrane curving proteins; sample preparation and SDSL, EPR, and computational refinement. Methods Enzymol 2015;564:259-288.

(88) Beasley KN, Sutch BT, Hatmal MM, Langen R, Qin PZ, Haworth IS. Computer modeling of spin labels: NASNOX, PRONOX and ALLNOX. Methods Enzymol 2015;563:569-593.

(87) Law MJ, Lee DS, Lee CS, Anglim PP, Haworth IS, Laird-Offringa IA. The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA. Nucleic Acids Res

2013;41:7092-7100.

(86) Romero RM, Rojsitthisak P, Haworth IS. Electrophoretic mobility of duplex DNA crosslinked by mechlorethamine at a cytosine-cytosine mismatch pair. Electrophoresis 2013;34:917-924.

(85) Li Y, Hatmal MM, Langen R, Haworth IS. Idealized models of protofilaments of human islet amyloid polypeptide. J Chem Inf Model 2012;52:2983-2991.

(84) Popova A, Hatmal MM, Frushicheva M, Price EA, Qin PZ, Haworth IS. Nitroxide sensing of a DNA microenvironment: mechanistic insights from EPR spectroscopy and molecular dynamics simulations. J Phys Chem B 2012;116:6387-6396.

(83) Zhang X, Tsung CS, Zowa GZ, Hatmal MM, Haworth IS, Qin PZ. Global structure of a three-way junction in a phi29 packaging RNA dimer determined using site-directed spin labeling. J Am Chem Soc 2012;134:2644-2652.

(82) Bedrood S, Li Y, Isas JM, Hegde BG, Baxa U, Haworth IS, Langen R. Fibril structure of human islet amyloid polypeptide. J Biol Chem 2012;287:5235-41.

(81) Hatmal MM, Li Y, Hegde BG, Hegde PB, Jao CC, Langen R, Haworth IS. Computer modeling of nitroxide spin labels on proteins. Biopolymers 2012;97:35-44.

(80) Li Y, Sutch BT, Bui HH, Gallaher TK, Haworth IS. Modeling of the water network at protein-RNA interfaces. J Chem Inf Model 2011;51:1347-1352.

(79) Rojsitthisak P, Jongaroonngamsang N, Romero RM, Haworth IS. HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. PLoS ONE 2011;6:e20745.

(78) Xu L, Li Y, Haworth IS, Davies DL. Functional role of the intracellular loop linking transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1. J Membr Biol 2010;238:43-49.

(77) Jao CC, Hegde BG, Gallop JL, Hegde PB, McMahon HT, Haworth IS, R.Langen. Roles of amphipathic helices and the BAR domain of endophilin in membrane curvature generation. J Biol Chem 2010;285:20164-20170.

(76) Sutch BT, Chambers EJ, Bayramyan MZ, Gallaher TK, Haworth IS. Similarity of protein-RNA interfaces based on motif analysis. J Chem Inf Model 2009;49:2139-2146.

(75) Xu L, Haworth IS, Kulkarni AA, Bolger MB, Davies DL. Mutagenesis and cysteine scanning of transmembrane 10 of the human dipeptide transporter. Pharm Res 2009;26:2358-2366.

(74) Tsai AG, Engelhart AE, Hatmal MM, Houston SI, Hud NV, Haworth IS, Lieber MR. Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites. J Biol Chem 2009;284:7157-7164.

(73) Jao CC, Hegde BG, Chen J, Haworth IS, Langen R. Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement. Proc Natl Acad Sci USA 2008;105:19666-19671.

(72) Zheng Y, Chow AHL, Haworth IS. Molecular modeling of flavonoid--cyclodextrin complexes. Lett Drug Des Disc 2008;5:512-520.

(71) K.Li, L.Xu, Kulkarni AA, D.I.Perkins, Haworth IS, Davies DL. Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes.

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Alcohol Clin. Exp. Res 2008;32:777-784.

(70) Dowd C, Sutch BT, Haworth IS, Eritja R, Marquez VE, Yang AS. Incorporation of zebularine from its 2'-deoxyribonucleoside triphosphate derivative and activity as a template-coding nucleobase. Nucleosid Nucleotid Nucleic Acids 2008;27:131-145.

(69) Qin PZ, Haworth IS, Cai Q, Kusnetzow AK, Grant GPG, Price EA, Sowa GZ, Popova A, Herreros B, He H. Measuring nanometer distances in nucleic acids using a sequence-independent nitroxide probe. Nature Protocols 2007;2:2354-2365.

(68) Price EA, Sutch BT, Cai Q, Qin PZ, Haworth IS. Computation of nitroxide-nitroxide distances in spin-labeled DNA duplexes. Biopolymers 2007;87:40-50.

(67) Cai Q, Kusnetzow AK, Hideg K, Price EA, Haworth IS, Qin PZ. Nanometer distance measurements in RNA using site-directed spin labeling. Biophys J 2007;93:2110-2117.

(66) Schiewe AJ, Haworth IS. Structure-based prediction of MHC-peptide association: algorithm comparison and application to cancer vaccine design. J Mol Graph Model 2007;26:667-675.

(65) Links JLS, Kulkarni AA, Davies DL, Lee VHL, Haworth IS. Cysteine scanning of transmembrane domain three of the human dipeptide transporter: implications for substrate transport. J Drug Target 2007;15:218-25.

(64) Bui HH, Schiewe AJ, Haworth IS. WATGEN: an algorithm for modeling water networks at protein-protein interfaces. J Comp Chem 2007;28:2241-2251.

(63) Kulkarni AA, Davies DL, Links JS, Patel LN, Lee VHL, Haworth IS. A charge pair interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane segment 8 of the human dipeptide transporter hPepT1. Pharm Res 2007;24:66-72.

(62) Cai Q, Kusnetzow AL, Hubbell WL, Haworth IS, Gacho GPC, van Eps N, Hideg K, Chambers EJ, Qin PZ. Site-directed spin labeling measurements of nanometer distances in nucleic acids using a sequence-independent nitroxide probe. Nucleic Acids Res 2006;34:4722-4730.

(61) Law MJ,.Linde ME, Chambers EJ, Oubridge C, Katsamba PS, Nillson L, Haworth IS, Laird-Offringa IA. The role of positively charged amino acids and electrostatic interactions in the complex of U1A protein and U1 hairpin II RNA. Nucleic Acids Res 2006;34:275-285.

(60) Bui HH, Schiewe AJ, von Grafenstein H, Haworth IS. Structural prediction of peptides binding to mhc class i molecules. Proteins 2006;63:43-52.

(59) Law MJ, Chambers EJ, Katsamba PS, Haworth IS, Laird-Offringa IA. Kinetic analysis of the role of the tyrosine 13, phenylalanine 56, and glutamine 54 network in the U1A/U1 hairpin II interaction. Nucleic Acids Res 2005;33:2917-2928.

(58) Raghavan SC, Chastain P, Lee JS, Houston S, Hegde BG, R.Langen, Hsieh CL, Haworth IS, Lieber MR. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. J Biol Chem 2005;280:22749-22760.

(57) Zheng Y, Haworth IS, Zuo Z, Chow MSS, Chow AHL. Physicochemical and structural characterization of quercetin-β-cyclodextrin complexes. J Pharm Sci 2005;94:1079-1089.

(56) Yu K, Roy D, Bayramyan M, Haworth IS, Lieber MR. Fine-structural analysis of activation-induced deaminase accessibility to class switch region R-loops. Mol Cell Biol 2005;25:1730-1736.

(55) Raghavan SC, Houston S, Hegde BG, Langen R, Haworth IS, Lieber MR. Stability and 3

strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region. J Biol Chem 2004;279:46213-46225.

(54) Kulkarni AA, Haworth IS, Uchiyama T, Lee VHL. Analysis of transmembrane segment 7 of the dipeptide transporter hPepT1 by cysteine scanning mutagenesis. J Biol Chem 2003;278:51833-51840.

(53) Kulkarni AA, Haworth IS, Lee VHL. Transmembrane segment 5 of the dipeptide transporter hPepT1 is an amphipathic helix that forms part of the substrate translocation pathway. Biochem Biophys Res Commun 2003;21:111-125.

(52) Chambers EJ, Price EA, Bayramyan MZ, Haworth IS. Computation of DNA backbone conformations. J Biomol Struct Dyn 2003;306:177-185.

(51) Katsamba PS, Bayramyan MZ, Haworth IS, Myszka DG, Laird-Offringa IA. Complex role of the 2-3 loop in the interaction of U1A with U1 hairpin II RNA. J Biol Chem 2002;277:33267-33274.

(50) Rojsitthisak P, Romero RM, Haworth IS. Extrahelical cytosine bases in DNA Duplexes containing d[GCC]nd[GCC]n repeats: detection by a mechlorethamine crosslinking reaction. Nucleic Acids Res 2001;29:4716-4723.

(49) Romero RM, Rojsitthisak P, Haworth IS. DNA Interstrand crosslink formation by mechlorethamine at a cytosine-cytosine mismatch pair: kinetics and sequence dependence. Arch Biochem Biophys 2001;386:143-153.

(48) Rodger A, K.J.Sanders, M.J.Hannon, I.Meistermann, A.Parkinson, D.S.Vidler, Haworth IS. DNA structure control by polycationic species: polyamine, cobalt ammines, and di-metallo transition metal chelates. Chirality, 2000, 12:221-236.

(47) Meng WS, von Grafenstein H and Haworth IS. Water dynamics at the HLA-A2 / peptide interface. Int Immunol 2000;12:949-957.

(46) Meng WS, Bui HH, Haworth IS. Exploiting the peptide-MHC water interface in the computer-aided design of non-natural peptides that bind to the class I MHC molecule HLA-A2. Mol Sim 2000;24:215-229.

(45) Gurlo T, Meng WS, Bui HH, Haworth IS, Von Grafenstein H. Experimental evidence for the presence of a water network at the peptide-MHC interface. Immunol Lett 1999;70:139-141.

(44) Lee VHL, Chu C, Mahlin ED, Basu SK, Ann DK, Bolger MB, Haworth IS, Yeung AK, Wu SK, Hamm-Alvarez S, Okamoto CT. Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1. J Contr Rel 1999;62:129-140.

(43) Coggan DZM, Haworth IS, Bates PJ, Robinson A, Rodger A. DNA binding of ruthenium tris(1,10-phenanthroline): evidence for the dependence of binding mode on metal complex concentration. Inorg Chem 1999;38:4486-4497.

(42) Shamma T, Haworth IS. Spermine inhibition of the 2,5-diaziridinyl-1,4-benzoquinone (DZQ) crosslinking reaction with DNA duplexes containing poly(purine)poly(pyrimidine) tracts. Nucleic Acids Res 1999;27:2602-2609.

(41) Romero RM, Mitas M, Haworth IS. Anomalous crosslinking by mechlorethamine of DNA duplexes containing C-C mismatch pairs. Biochemistry 1999;38:3641-3648.

(40) Bolger MB, Haworth IS, Yeung AK, Ann D, von Grafenstein H, Hamm-Alvarez SF,

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Okamoto CT, Basu SK, Wu S, Lee VHL. Structure, function and molecular modeling approaches to the study of the intestinal dipeptide transporter PepT1. J Pharm Sci 1998;87:1286-1291.

(39) Yeung AK, Basu SK, Wu SK, Chu C, Okamoto CT, Hamm-Alvarez SF, von Grafenstein H, Shen WC, Kim KK, Bolger MB, Haworth IS, Ann DK, Lee VHL. Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton-coupled dipeptide transporter (hPepT1). Biochem Biophys Res Commun 1998;250:103-107.

(38) Basu SK, Haworth IS, Bolger MB, Lee VHL. Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells. Invest Ophth Vis Sci 1998;39:12:2365-2373.

(37) Meng WS, Bhavaraju A, von Grafenstein H, Haworth IS. Modeling of the non-obese diabetic mouse class II MHC molecule I-Ag7. Protein Peptide Lett 1998;5:75-82.

(36) Blagbrough IS, Taylor S, Carpenter ML, Novoselskiy V, Shamma T, Haworth IS. Asymmetric intercalation of acridine-9-carbonyl-N1-spermine at homopurine sites of duplex DNA. J Chem Soc Chem Commun 1998:929-930.

(35) Meng WS, von Grafenstein H, Haworth IS. A model of water structure inside the HLA-A2 peptide binding groove. Int Immunol 1997;9:1339-1346.

(34) Yu A, Romero RM, Barron MD, Dill J, Christy M, Gold B, Gray DM, Haworth IS, Mitas M. At physiological pH d(CCG)15 forms a hairpin containing protonated cytosines and a distorted helix. Biochemistry 1997;36:3687-3699.(33) Meng WS, Gallaher TK, Von Grafenstein H, Haworth IS. Sequence dependent conformational motion of a peptide in the HLA-A2 binding groove. Protein Peptide Lett 1996;3:51-58.(32) Yuki M, Grukhin V, Lee CS, Haworth IS. Spermine binding to GC-Rich DNA: experimental and theoretical studies. Arch Biochem Biophys 1996;325:39-46.

(31) Mitas M, Yu A, Dill J, Haworth IS. The trinucleotide DNA repeat sequence d(CGG)15 forms a heat-stable hairpin containing Gsyn.Ganti base pairs. Biochemistry 1995;34:12803-12811.

(30) Yu A, Dill J, Wirth SS, Huang G, Lee VH, Haworth IS, Mitas M. The trinucleotide repeat sequence d(GTC)15 adopts a hairpin conformation. Nucleic Acids Res 1995;23:2706-2714.

(29) Daude N, Gallaher TK, Zeschnigk M, Starzinski-Powitz A, Petry KG, Haworth IS, Reichardt JKV. Molecular cloning, characterization and mapping of a full-length cDNA encoding human UDP-galactose 4' epimerase. Biochem Mol Med 1995;56:1-7.

(28) Rodger A, Taylor S, Adlam G, Blagbrough IS, Haworth IS. Multiple DNA binding modes of anthracene-9-carbonyl-N1-spermine. Bioorg Med Chem 1995;3:861-872.

(27) Mitas M, Yu A, Dill J, Kamp TJ, Chambers EJ, Haworth IS. Hairpin properties of single-stranded DNA containing a GC-rich triplet repeat: (CTG)15. Nucleic Acids Res 1995;23:1050-1059.

(26) Remias MG, Lee CS, Haworth IS. Molecular dynamics simulations of chlorambucil / DNA adducts. A structural basis for the 5'-GNC interstrand DNA crosslink formed by nitrogen mustards. J Biomol Struct Dyn 1995;12:911-936.

(25) Adlam G, Blagbrough IS, Taylor S, Latham HC, Haworth IS, Rodger A. Multiple binding modes with DNA of anthracene-9-carbonyl-N1-spermine probed by LD, CD, normal absorption and molecular modelling compared with those of spermidine and spermine. Bioorg Med Chem

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Lett 1994;4:2435-2440.

(24) Chambers EJ, Haworth IS. A stable cis-azobenzene in aqueous solution. J Chem Soc Chem. Commun 1994:1631-1632.

(23) Gallaher TK, Haworth IS, Shih JC. Determination of the agonist binding site of the 5-HT2 receptor using molecular mechanics and molecular dynamics. Med Chem Res 1993;3:344-356.

(22) Jabs EW, Muller U, Li X, Ma L, Luo W, Haworth IS, Klisak I, Sparkes R, Warman ML, Mulliken JB, Snead ML, Maxson R. A mutation in the homeodomain of the human MSX2 Gene in a family affected with autosomal-dominant craniosynastosis. Cell 1993;75;443-450.

(21) Haworth IS, Lee CS, Yuki M, Gibson NW. Molecular dynamics simulations provide a structural basis for the experimentally observed nucleotide preferences of DNA interstrand cross-links induced by aziridinylbenzoquinones. Biochemistry 1993;32:12857-12863.

(20) Hutchin T, Haworth IS, Higashi K, Fischel-Ghodsian N, Stoneking M, Saha N, Cortopassi G. A molecular basis for human hypersensitivity to aminoglycoside antibiotics. Nucleic Acids Res 1993;21:4174-4179.

(19) Yuki M, Haworth IS. The DNA complexes of aziridinylbenzoquinones. A molecular mechanics study. Anti-Cancer Drug Design 1993;8:269-287.

(18) S.R.Sanghani, Elcock AH, Haworth IS. SUBCUR: visualisation of structural variance in DNA duplexes. J Mol Graph 1993;11:211-213.

(17) Haworth IS, Rodger A, Richards WG. A molecular dynamics simulation of a polyamine-induced conformational change of DNA. A possible mechanism for the B to Z transition. J Biomol Struct Dyn 1992;10:195-211.

(16) Haworth IS, Elcock AH, Rodger A, Richards WG. A binding mode of -[tris(1,10-phenanthroline) ruthenium(II)]2+ exhibiting preference for purine-3',5'-pyrimidine sites of DNA. J Biomol Struct Dyn 1991;9:553-569.

(15) Haworth IS, Elcock AH, Freeman J, Rodger A, Richards WG. Sequence selective binding to the DNA major groove. Tris(1,10-phenanthroline) metal complexes binding to poly(dG-dC) and poly(dA-dT). J Biomol Struct Dyn 1991;9:23-44.

(14) Haworth IS, Rodger A, Richards WG. A molecular mechanics study of spermine complexation to DNA: a new model for spermine-poly(dG-dC) binding. Proc Roy Soc Lond B 1991;244:107-116.

(13) Haworth IS, Burt C, Gago F, Reynolds CA, Richards WG. A prototype bioreductive DNA groove binding ligand. Anti-Cancer Drug Design 1991;6:59-70.

(12) Morley SD, Abraham RJ, Haworth IS, Jackson DE, Saunders MR, Vinter JG. COSMIC90 - an improved molecular mechanics treatment of hydrocarbons and conjugated systems. J Comput-Aided Mol Design 1991;5:475-504.

(11) Abraham RJ, Grant GH, Haworth IS, Smith PE. Charge calculations in molecular mechanics. Atomic charges from classical calculations. J Comput-Aided Mol Design 1991;5:21-39.

(10) Abraham RJ, Haworth IS, Bunn A, Hearmon RA. The 13C NMR spectra of aryl ether copolymers. Sulphonated aryl ether ketones. Polymer 1991;32:1414-1419.

(9) Abraham RJ, Haworth IS. Molecular modelling of poly(aryl ether ketones). Chain packing in crystalline PEK and PEEK. Polymer 1991;32:121-126.

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(8) Abraham RJ, Haworth IS. Molecular modelling of poly(aryl ether ketones). Aryl..aryl interactions in crystal structures. J Comput-Aided Mol Design 1990;4:283-294.

(7) Abraham RJ, Haworth IS, Bunn A, Hearmon RA. The 13C NMR spectra of aryl ether copolymers. Aryl ether ketone copolymers in acid solution. Polymer 1990;31:728-735.

(6) Abraham RJ, Haworth IS, Bunn A, Hearmon RA. The 13C NMR spectra of aryl ether copolymers. Materials containing sulphonated aryl rings. Polymer 1990;31:126-129.

(5) Abraham RJ, Haworth IS, Bunn A, Hearmon RA. The 13C NMR spectra of aryl ether copolymers. The effect of biphenyl functionality. Polymer 1989;30:1169-1972.

(4) Abraham RJ, Haworth IS. A modification to the COSMIC parameterisation using ab initio-constrained potential functions. J Comput-Aided Mol Design 1988;2:125-135.

(3) Abraham RJ, Haworth IS, Bunn A, Hearmon RA. The 13C NMR spectra of aryl ether copolymers. Ether sulphone / ether ether sulphones and ether sulphone / ether ketone in deuterated DMSO. Polymer 1988;29:1110-1117.

(2) Abraham RJ, Haworth IS. A lanthanide induced shift (LIS) study of aryl sulphones using a novel lanthanide-sulphone complexation model. Magn Reson Chem 1988;26:252-259.

(1) Abraham RJ, Haworth IS. A theoretical and lanthanide induced shift (LIS) study of benzophenone and 3,4'-dichlorobenzophenone. J Chem Soc Perkin Trans 2 1988:1429-1437.

Submitted Manuscripts

(1) Coricello A, Perri F, Luna M, Ferrario A, El-Magboub A, Haworth IS, Aiello A, Williams T, Nguyen C, Lien EJ, Gomer CJ, Adams JD. Sesquiterpene-based cyclooxygenase 2 pharmacology and enhancement of photodynamic therapy. Future Med Chem 2016, submitted.

Reviews, Book Chapters and Other Publications

(10) El-Magboub A, Rojsitthisak P, Muangnoi C, Wichitnithad W, Romero RM, Haworth IS. Biological targets and pharmacology of curcumin. In: Curcumin: Synthesis, Emerging Role in Pain Management and Health Implications, Ed. Pouliquen DL. Nova Science Publishers 2014;103-133.

(9) Rojsitthisak P, Wichitnithad W, Muangnoi C, El-Magboub A, Romero RM, Haworth IS. Design, synthesis and biological activities of curcumin prodrugs. In: Curcumin: Synthesis, Emerging Role in Pain Management and Health Implications, Ed. Pouliquen DL. Nova Science Publishers 2014;135-175.

(8) Jongaroonngamsang N, Romero RM, Haworth IS, Rojsitthisak P. HPLC-UV determination of a mechlorethamine crosslink in a DNA duplex containing a cytosine-cytosine mismatch pair. J Health Res 2010;24:155-160.

(7) Lertsutthiwong P, Haworth IS, Rojsitthisak P. Alginate: A promising polysaccharide for delivery of essential oils. In: Carbohydrate Polymers: Development, Properties and Applications. Eds. Ito R, Matsuo Y. Nova Science Publishers, Hauppauge, NY, 2010.

(6) Sutch BT, Haworth IS. Development of a protein-nucleic acid interaction database: potential for use in drug design against any protein target. Proceedings of the 9th APRU Doctoral Students Conference. Far Eastern National University, Vladivostok, Russia, 2008.

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(5) Haworth IS. Computational drug delivery. Adv Drug Deliv Rev 2006;58:1271-1273.

(4) Schiewe AJ, Haworth IS. Avian influenza vaccine development: computational epitope identification through structural prediction of MHC-peptide association. Proceedings of the 7th APRU Doctoral Students Conference: Inventing the Future: Trends, Perspectives and Enterprise from the Pacific Rim, National University of Singapore, 2006.

(3) Haworth IS. Monograph on protein solubility. In Chemistry: Foundations and Applications, Ed. Lagowski J, Macmillan Reference USA, 2004.

(2) Haworth IS. Monograph on ibuprofen. In Chemistry: Foundations and Applications, Ed. Lagowski J, Macmillan Reference USA, 2004.

(1) Romero RM, Cheng HY, Mitas M, Haworth IS. Molecular dynamics simulations of DNA molecules containing d(GCC)n..d(GCC)n fragments and C-C mismatch pairs. In Structure, Motion, Interaction and Expression of Biological Macromolecules, Volume 2. Proceedings of the 10th Conversation in Biomolecular Stereodynamics, Albany, N.Y. Eds. Sarma RH, Sarma MH, Adenine Press, 1998.

Invited Lectures

(63) 'Computational Molecular Docking'. University of the Philippines, Manila, Philippines, December 2016.

(62) 'Algorithms for Computer Modeling: EPR-based Protein Structure and Solvation of Protein-Ligand Interfaces'. USC Biophysics Program, Los Angeles, CA, September 2016.

(61) ‘Computational Biochemistry: Protein Structure, Spin Labels and Solvation'. Universiti Teknologi MARA (UiTM), Puncak Alam, Malaysia, November 2015.

(60) ‘Computer Modeling in Drug Discovery and Target Development'. 4th International Conference on Pharmaceuticals, Nutraceuticals and Cosmetic Science (IPNaCS), Melaka, Malaysia, November 2015.

(59) ‘Solubility in Drug Formulation and Solvation in Drug-Target Interactions’. 31st International Annual Meeting in Pharmaceutical Sciences, Bangkok, Thailand, January 2015.

(58) ‘The Human Dipeptide Transporter (hPEPT1): Mutagenesis Data and Structure’. Vincent H.L. Lee Symposium, University of Colorado, Denver, CO, June 2012.

(57) ‘Lipid-Bound Proteins and Amyloid Fibrils: Structures from EPR and Computer Modeling’. Chulalongkorn University, Bangkok, Thailand, August 2011.

(56) ‘Structure Determination using EPR and Computer Modeling’. UCSF, San Francisco, CA, April 2009.

(55) ‘Structure Determination using EPR and Computer Modeling’. R.J. Abraham Symposium, Manchester, UK, October 2008.

(54) ‘Nucleic Acids in Silico: Therapeutic Agents & Biochemical Targets’. Simulations Plus, Lancaster, CA, January 2008.

(53) ‘Drugs Based on Peptides and Nucleotides’. Chulalongkorn University, Bangkok, Thailand, August 2007.

(52) ‘Structural Basis of Peptide-MHC Association: Peptide Vaccine Design’. USC Norris Cancer Center Grand Rounds, Los Angeles, CA, July 2007.

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(51) ‘Computer Modeling in Drug Discovery and Delivery’. MannKind Corporation, Valencia, CA, March 2007.

(50) ‘Computer Modeling in Drug Discovery and Delivery’. Dept. of Chemistry & Biochemistry, California State University, Los Angeles, Los Angeles, CA, January 2007.

(49) ‘Computer Modeling of Biomolecular Structure’. USC Department of Biochemistry & Molecular Biology Retreat, Newport Beach, CA, October 2006.

(48) ‘Computational Approaches to Prediction of pKa and logD’. AAPS Annual Meeting, Nashville, TN, November 2005.

(47) ‘Computer Modeling, Drug Development and Nanotechnology’. Mahidol University, Bangkok, Thailand, August 2005.

(46) ‘DNA Condensation: Modeling, Nanotechnology and Gene Delivery’. Nanotechnology and Drug Discovery Meeting, Chulalongkorn University, Bangkok, Thailand, August 2005.

(45) ‘Computational Molecular Docking and Molecular Bioinformatics’. Nanotechnology and Drug Discovery Meeting, Chulalongkorn University, Bangkok, Thailand, August 2005.

(44) ‘Peptide-Based Drug Discovery’. Nanotechnology and Drug Discovery Meeting, Chulalongkorn University, Bangkok, Thailand, August 2005.

(43) ‘Nucleic Acid-Based Drug Discovery’. Nanotechnology and Drug Discovery Meeting, Chulalongkorn University, Bangkok, Thailand, August 2005.

(42) ‘Computer Modeling of Transporter Proteins: Molecular Informatics and Translocation Pathways’. Controlled Release Society, Miami Beach, FL, June 2005.

(41) ‘Computational Docking of Biological Macromolecules: Protein-RNA and Protein-Peptide Interfaces’. Pharmaceutical Sciences World Congress 2004, Kyoto, Japan, June 2004.

(40) ‘Promiscuous Proteins and Slippery DNA: Computer Modeling of Biomolecular Structure’, Phi Sigma Biological Honors Society, University of Southern California, Los Angeles, CA, February 2004.

(39) ‘Computer Modeling of Biomolecular Interfaces: Protein Interactions with Peptides and Nucleic Acids’. USC Department of Biochemistry & Molecular Biology Retreat, Laguna Beach, CA, November 2003.

(38) ‘Chemistry of the Mustard-DNA Crosslink: From C-C DNA to eE-DNA’. Cerus Corporation, Concord, CA, May 2003.

(37) ‘Computer Prediction of Peptide-MHC Association and Peptide Immunogenicity’. Division of Biostatistics, University of Southern California, Los Angeles, CA, February 2003.

(36) ‘Protein-Peptide Interactions: Binding and Transport’. Molecular Biopharmaceutics 2003, Honolulu, HI, January 2003.

(35) ‘Genomics, Computation and New Drug Targets’. AAPS Moving Targets Meeting, Los Angeles, CA, August, 2002.

(34) ‘Small Molecule - DNA Association: Chemistry and Computer Modelling’. Dept. of Chemistry, University of Canterbury, Christchurch, New Zealand, July 2002.

(33) ‘Triplet Repeat DNA: Structure and Slippage’. Dept. of Pharmaceutical Sciences, National University of Singapore, Singapore, July 2002.

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(32) ‘Computer Modeling of Proteins and Nucleic Acids: Relevance to Drug Design and Delivery’. Dept. of Pharmaceutical Sciences, National University of Singapore, Singapore, July 2002.

(31) ‘Computer Modeling of Proteins and Nucleic Acids: Relevance to Drug Design and Delivery’. Dept. of Pharmaceutical Sciences, Chinese University of Hong Kong, Hong Kong, July 2002.

(30) ‘Computer Modeling of Proteins and Nucleic Acids: Relevance to Drug Design and Delivery’. Sankyo Pharmaceutical Co., Tokyo, Japan, July 2002.

(29) ‘Computer Modeling of Proteins and Nucleic Acids: Relevance to Drug Design and Delivery’. Dept. of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan, July 2002.

(28) ‘Promiscuous Proteins and Slippery DNA: Computer Modelling of Biomolecular Structure’. Dept. of Plant & Microbial Sciences, University of Canterbury, Christchurch, New Zealand, June 2002.

(27) ‘Triplet Repeat DNA: Structure, Slippage and Crosslinking Reactions’. University of Auckland Cancer Centre, Auckland, New Zealand, June 2002.

(26) ‘Triplet Repeat DNA: Structure and Slippage’. Dept. of Chemistry and Biochemistry, California State University Fullerton, Fullerton, CA, March 2002.

(25) ‘Conformations of Fragile X-Associated Triplet Repeat DNA Containing C-C Mismatch Pairs’. American Chemical Society Meeting, San Diego, CA, April 2001.

(24) ‘Triplet Repeat DNA: Conformation and Slippage’. Dept. of Chemistry and Biochemistry, California State University Northridge, Northridge, CA, March 2001.

(23) ‘Pharmacogenomics and Drug Development’. Eino Nelson Conference, Captiva Island, FL, January 2001.

(22) ‘Modeling of Transmembrane and Cell Surface Proteins’. University of the Saarland, Saarbrucken, Germany, March 2000.

(21) ‘Computer Modeling and Drug Design’. USC-Japan Symposium, Pasadena, CA, July 1999.

(20) ‘DNA Interstrand Crosslinking: New Chemistry and Biophysics’. USC-Norris Cancer Center Grand Rounds, University of Southern California, Los Angeles, CA, July 1999.

(19) ‘MHC-Peptide Interactions: Specificity, Promiscuity and the Role of Water’. Virtual Lecture, MolSim99 Electronic Conference, April 1999.

(18) ‘DNA Crosslinking Reactions: Revisiting the Old, Understanding the New’. Welsh School of Pharmacy, University of Cardiff, Cardiff, U.K., March 1999.

(17) ‘MHC-Peptide Interactions: Specificity, Promiscuity and the Role of Water’. School of Pharmacy and Pharmacology, University of Bath, Bath, U.K., March 1999.

(16) ‘DNA Crosslinking Reactions: Revisiting the Old, Understanding the New’. Dept. of Chemistry, Reading University, Reading, U.K., March 1999.

(15) ‘MHC-Peptide Interactions: Specificity, Promiscuity and the Role of Water’. Dept. of Biological Sciences, University of Essex, Colchester, U.K., March 1999.

(14) ‘Peptide Inhibitors of TGF-beta Based on Computer Models of TGF-beta Receptor Structure’. AAPS Western Regional Meeting, San Francisco, CA, April 1998.

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(13) ‘Mechlorethamine Crosslinking of d(CCG)n Trinucleotide Repeat DNA’.10th Conversation in Biomolecular Stereodynamics, Albany, NY, June 1997.

(12) ‘Computer Modeling of Proteins and DNA : Peptide-MHC and DNA-DZQ.’. Dept. of Biochemistry. & Molecular Biology, Oklahoma State University, Stillwater, OK, November 1995.

(11) ‘Aziridnylquinone-DNA Interactions Studied by Computer Simulation’. AAPS Annual Meeting, Miami Beach, FL, November 1995.

(10) ‘Computer Modeling of Repeat Sequence DNA: d(GC)n.d(GC)n and d(CCG)n.d(GGC)n’. Children’s Hospital of Los Angeles, Los Angeles, CA, October 1995.

(9) ‘Computer Modeling of the Anthracene-9-carbonyl-N1-spermine Complex with DNA’. AAPS Annual Meeting, San Diego, CA, November 1994.

(8) ‘Computer Modeling of DNA Alkylation Reactions’. Dept. of Chemistry & Biochemistry, California State University, Los Angeles, Los Angeles, CA, November 1993.

(7) ‘Computer Modeling of the Chlorambucil / DNA Interaction’. AAPS Annual Meeting, Orlando, FL, November 1993.

(6) ‘Computer Modeling of DNA’. Dept. of Biochemistry & Molecular Biology, University of Southern California, Los Angeles, CA, May 1993.

(5) ‘Dynamics of DNA Structure and the B to Z Transition’. Program for Mathematics and Molecular Biology, Santa Fe, NM, November 1992.

(4) ‘Modeling Ligand Binding in the DNA Major Groove’. Royal Society of Chemistry Meeting, ‘Progress in Computer Modeling of Biomolecules’, University of Nottingham, U.K., March 1992.

(3) ‘Polyamine / DNA Interactions’. Molecular Graphics Society Meeting, Merck U.K., Harlow, U.K., December 1991.

(2) ‘The Development of Potential Functions in the COSMIC Force Field’. University of Nottingham, U.K., September 1991.

(1) ‘N.M.R. and Computational Studies of Polymer Structure’. Dept. of Organic Chemistry, University of Liverpool, U.K., February 1989.

Abstracts

80 published abstracts (available on request)

Professional Activities

Visiting Professor, University of the Phillippines, Manila, Philippines, December 2016.

Reviewer, AACP New Investigator Awards, October 2016.

Program Review, University of Arizona School of Pharmacy, October 2016.

Program Review, Western University of Health Sciences, MS Pharmaceutical Sciences, September 2016.

Coordinator: Seventh USC-Taiwan Summer Course in Drug Discovery, July 2016.

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Organizer: USC School of Pharmacy Retreat, May 2016.

Visiting Professor, Chulalongkorn University, Bangkok, Thailand, January, 2015.

Judge, California Science Fair, Los Angeles, CA, May, 2014.

Coordinator: Fourth USC-Taiwan Summer Course in Drug Discovery, July 2013.

Judge, California Science Fair, Los Angeles, CA, May, 2013.

Editorial Advisory Board: Thai Journal of Pharmaceutical Sciences, 2012-

Visiting Professor, Chulalongkorn University, Bangkok, Thailand, August, 2012.

Coordinator: Third USC-Taiwan Summer Course in Drug Discovery, July 2012.

Editorial Advisory Board: Computational Molecular Biosciences, 2011-

Visiting Professor, Chulalongkorn University, Bangkok, Thailand, August, 2011.

Coordinator: Second USC-Taiwan Summer Course in Drug Discovery, July 2011.

Judge, Intel ISEF Science Fair, Los Angeles, CA, May, 2011.

Judge, California Science Fair, Los Angeles, CA, May, 2011.

Editorial Advisory Board: Analytical Biochemistry, 2011-

Coordinator: First USC-Taiwan Summer Course in Drug Discovery, July 2010

Editorial Advisory Board: World Journal of Biological Chemistry, 2009-

Visiting Professor, Chulalongkorn University, Bangkok, Thailand, August, 2009.

Reviewer, Louisiana Board of Regents Research Program, December, 2007-2009.

Editorial Advisory Board: Current Proteomics, 2007-2014

Co-Organizer, 3rd Interdisciplinary Program in Drug Discovery (IPIDD) Meeting, Burbank, CA, September, 2007.

Visiting Professor, Chulalongkorn University, Bangkok, Thailand, August, 2007.

Reviewer, Louisiana Board of Regents Support Fund for Research & Development, January, 2007.

Reviewer, U.S. Civilian R&D Foundation BRHE Fellowships, September, 2006.

Co-Organizer, 2nd Interdisciplinary Program in Drug Discovery (IPIDD) Meeting, La Canada, CA, June, 2006.

Theme Editor, “Computer Modeling in Drug Delivery”, Advanced Drug Delivery Reviews, 2006.

Visiting Professor, Chulalongkorn University, Bangkok, Thailand, August, 2005.

Symposium Chair, “Bioinformatics and Computer Modeling in Drug Targeting and Delivery”, Controlled Release Society, Miami Beach, June, 2005.

Co-Organizer, 1st Interdisciplinary Program in Drug Discovery (IPIDD) Meeting, La Canada, CA, June, 2005.

External Thesis Reviewer, Liu Jining, National University of Singapore, October, 2004.

Reviewer, AAAS Cobre Program, June, 2004.

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External Thesis Reviewer, Poon Thong Yuen, National University of Singapore, March, 2004.

Member of Programming Committee and Abstract Reviewer, AAPS National Biotech Meeting, Boston, May, 2004.

Symposium Co-Organizer and Moderator; “Nucleic Acids, Drug Targets and Gene Therapy”, AAPS Annual Meeting, Salt Lake City, October, 2003.

Symposium Co-Organizer and Moderator; “Proteomics and Chemo-Informatics in Drug Discovery and Development”, AAPS Annual Meeting, Salt Lake City, October, 2003.

Member of Annual Meeting Planning Committee, AAPS Annual Meeting, Salt Lake City, October, 2003.

Chair, Abstract Review Committee, Drug Design & Discovery Section, AAPS Annual Meeting, Salt Lake City, October, 2003.

Vice-Chair, Drug Design & Discovery (DDD) Section: American Association of Pharmaceutical Scientists (AAPS), 2003.

Abstract Reviewer, AAPS National Biotech Meeting, Boston, June, 2003.

Chair, Abstract Review Committee, Drug Design & Discovery Section, AAPS Annual Meeting, Toronto, November, 2002.

Visiting Erskine Fellowship Professor, University of Canterbury, Christchurch, New Zealand, May-July, 2002.

Abstract Reviewer, AAPS National Biotech Meeting, San Diego, June, 2002.

Reviewer, South Carolina EPSCoR Program, March, 2002.

Vice-Chair Elect, Drug Design & Discovery (DDD) Section: AAPS, 2002.

Abstract Reviewer for Medicinal and Natural Products Section, AAPS Annual Meeting, Denver, October, 2001.

Co-Chair of Medicinal and Natural Products Podium Session, AAPS Annual Meeting, Indianapolis, November, 2000.

Abstract Reviewer for Medicinal and Natural Products Section, AAPS Annual Meeting, Indianapolis, November, 2000.

External Thesis Reviewer, Cairo University, Giza, Egypt, April, 2000.

Editorial Advisory Board: AAPS PharmSci, 1999 - 2008.

Abstract Reviewer for Medicinal and Natural Products Section, AAPS Annual Meeting, New Orleans, November, 1999.

Editorial Advisory Board: Pharmaceutical Research, 1998 - current.

Co-Chair of Medicinal and Natural Products Podium Session, ‘Polyamines, Peptides and Other Natural Products’, AAPS Annual Meeting, San Francisco, November, 1998.

Program Co-Organizer and Abstract Reviewer for Medicinal and Natural Products Section, AAPS Annual Meeting, San Francisco, November, 1998.

Chair of Medicinal and Natural Products Podium Session, ‘Drug Design, Synthesis and Mechanism of Action’, AAPS Annual Meeting, Boston, November, 1997.

Program Co-Organizer and Abstract Reviewer for Medicinal and Natural Products Section, 13

AAPS Annual Meeting, Boston, November, 1997.

Co-Chair of Trinucleotide Repeat DNA Colloquium, 10th Conversation in Biomolecular Stereodynamics, Albany, NY, June, 1997.

Chair of Medicinal and Natural Products Podium Session, AAPS Annual Meeting, Seattle, November, 1996.

Computer Programs and Websites

(12) ALLNOX. Flexible labeling of biomolecules (2015-). Beasley K, Sutch BT, Haworth IS; publication (88). <https://ihlab.hsc.usc.edu/allnox/>

(11) MFIBRIL. Building of fibril structure (2012-). Li Y, Haworth IS; publication (85). <http://chemsoft.hsc.usc.edu:8080/MFIBRIL/>

(10) SIMA (Similarity by Identity and Motif Analysis). Calculation of similarity of protein-RNA complexes (2009-). Sutch BT, Li Y, Bayramyan MZ, Haworth IS; v.1.0; publication (76).

(9) PRONOX (PROtein structure with NitrOXide Labels). Calculation of nitroxide spin label distributions in proteins (2008-). M.Hatmal, Li Y, Haworth IS; publication (81). <https://ihlab.hsc.usc.edu/pronox/ >

(8) NASNOX (Nucleic Acids: Structure with NitrOXide Labels). Calculation of nitroxide spin label distributions in DNA and RNA (2007-). Price EA, M.Hatmal, Haworth IS; v1.0 , publication (62); v.1.1, publication (67); v.1.1-W (NASNOX-W; Web version), publication (69). <http://pzqin.usc.edu/NASNOX/>

(7) WATGEN. Solvation of protein-protein interfaces (2006-). Li Y, Sutch BT, Bui HH, Schiewe AJ, Haworth IS; v.1.0, publication (64); v.1.1 (includes RNA and DNA), publication (80). <https://ihlab.hsc.usc.edu/watgen/ >

(6) PEPSSI (PEptide-MHC Prediction of Structure through Solvated Interfaces). A PC-based program for computation of MHC-peptide structure (2006). Bui HH, Schiewe AJ, Haworth IS; v.1.0, publication (60).

(5) NASDAC (Nucleic Acids: Structure, Dynamics and Conformation). A program for building of DNA structure (2001). Price EA, Chambers EJ, Bayramyan MZ, Haworth IS; v.1.0, abstract (40); v.1.01, publication (52); v.1.1, Price EA Ph.D. Thesis, 2008. <https://ihlab.hsc.usc.edu/nasdac/ >

(4) PHARMLAB: Teaching of structure/function relationships in drug degradation and illustration of chemical kinetics (1995). Bolger MB, Haworth IS; educational publication (2).

(3) NEMESIS: PC-based molecular modeling (Oxford Molecular, Oxford, U.K.) (1990) Contributions to force field development and implementation of energy functions; publication (12).

(2) CHARGE3: A package for rapid computation of atomic charges based on molecular dipoles (1990). Abraham RJ, B.D.Hudson. P.E.Smith. G.H.Grant, Haworth IS. (University of Liverpool, U.K.); publication (11).

(1) LIRAS4: Computation of NMR chemical shifts induced by lanthanide shift reagents (1987). Abraham RJ, Haworth IS (University of Liverpool, U.K.); publication (2).

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Education Publications

(9) El Magboub A, Haworth IS, Sutch BT, Romero RM. Evaluation of in-class and online discussion meetings in a biopharmaceutics problem-based learning class. Curr Pharm Teach Learn 2016;8:811-820

(8) Chatfield AJ, Romero RM, Haworth IS. Information intervention in the pharmaceutical sciences. Med Ref Serv Quart 2012;31:188-201.

(7) Sutch BT, Romero RM, Neamati N, Haworth IS. Integrated teaching of structure-based drug design and biopharmaceutics: A computer-based approach. J Chem Ed 2012;89:45-51.

(6) Romero RM, Eriksen SP, Haworth IS. Quantitative assessment of assisted problem-based learning in a pharmaceutics course. Am J Pharm Ed 2010;74:Article 66.

(5) Romero RM, Eriksen SP, Haworth IS. A decade of teaching pharmaceutics using case studies and problem-based learning. Am J Pharm Ed 2004;68:Article 31.

(4) Haworth IS, A. Garrill. Assessment of verbal communication in science education: a comparison of small and large classes. Biochem Mol Biol Ed 2003;31:24-27.

(3) Haworth IS, Eriksen SP, Chmait SH, Matsuda LS, McMillan PA, King EA, Letourneau-Wagner J, Shapiro K. A problem-based learning, case study approach to pharmaceutics: faculty and student perspectives. Am J Pharm Ed 1998;62:398-405.

(2) Bolger MB, Haworth IS. PharmLabTM: A computer program for the calculation and visualization of drug degradation pH rate profiles. Am J Pharm Ed 1997;61:281-287.

(1) Haworth IS, Bolger MB, Eriksen SP. The use of computer-based case studies in a problem-solving curriculum. Am J Pharm Ed 1997;61:97-102.

Education Presentations

(19) Lilly Conference. 'Problem-Based and Team-Based Learning Strategies in a Biopharmaceutics Course', Anaheim, CA, February 2017.

(18) University of the Philippines Manila. 'Learner-Centered, Case Study-Based Teaching in Pharmaceutical Sciences'. Manila, Philippines, December 2016.

(17) University of the Philippines Manila. 'Building Skills of Faculty Members for Pharm.D. Programs'. Manila, Philippines, December 2016.

(16) Turning Technologies User Conference. 'Reinforcement of Key Concepts in Biopharmaceutics using Clickers and Turning Point Polling'. Las Vegas, NV, October 2016.

(15) USC Libraries Strategic Planning Panel Discussion. 'Health Sciences Faculty Perspectives'. Los Angeles, CA, April 2016.

(14) UC Riverside School of Medicine. 'Automated Curriculum Mapping'. Riverside, CA, January 2016.

(13) Cyberjaya University College of Medical Sciences. ‘The Pharm.D. Program at USC: Curriculum Development and Problem-Based Learning’. Cyberjaya, Malaysia, November 2015.

(12) Universiti Teknologi MARA (UiTM). ‘The Pharm.D. Program at USC: Curriculum Development and Problem-Based Learning’. Puncak Alam, Malaysia, November 2015.

(11) USC Center for Exccellence in Teaching Panel Discussion. 'Roles for Teaching Assistants

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in the Sciences'. Los Angeles, CA, October 2015.

(10) National Nanotechnology Center, ‘Graduate Education’. Bangkok, Thailand, August 2012.

(9) Chulalongkorn University Faculty of Pharmaceutical Sciences, ‘Problem-Based Learning in Pharmacy Education’. Bangkok, Thailand, August 2012.

(8) USC MS Global Health Taiwan Visitors Program, ‘Pharmacy Education’. Los Angeles, CA, June 2012.

(7) USC School of Pharmacy Board of Councilors Annual Meeting. ‘Genomics, Proteomics and Bioinformatics: Implications for Pharmaceutical Research and Education’. Los Angeles, CA, October 2002.

(6) Talk and Panelist at the NIH Extramural Associates Meeting on Sponsored Research at Minority Institutions. ‘Partnerships and Collaborations at the University of Southern California’. Los Angeles, CA, May 1997.

(5) District 7&8 NABP / AACP Annual Meeting. ‘The Case Study Method Applied to a Basic Science Course in the Pharm.D. Curriculum’. Sacramento, CA, November 1996.

(4) Poster at AACP Annual Meeting. 'The Use of Computers in a Problem-Solving Curriculum. Case Studies in the Kinetics of Drug Degradation and in the Flocculation of Dispersed Systems', Reno, NV, July 1996.

(3) Poster at AACP Annual Meeting. 'PharmLab: A Simulation Program for the Estimation of Drug Degradation pH Rate Profiles. Use in a Case Study-Based Problem-Solving Curriculum. Bolger MB, Haworth IS. Reno, NV, July 1996.

(2) Submission to the AACP ‘Innovations in Teaching’ Competition. Received Honorable Mention. AACP Annual Meeting, Reno, NV, July 1996.

(1) Poster presentation by Avi Bhavaraju, California State High School Science Fair, in conjunction with the USC-Bravo High School partnership (STAR). A.Bhavaraju, Meng WS and Haworth IS. ‘Computer modeling of peptide interactions with class II MHC molecules’, May 1996.

Research Students

Ph.D.1992-1997 Masayuki Yuki: ‘Polyamine-DNA Complexes: Experiment and Theory’1993-1998 Wilson Meng: ‘Simulation and Binding Studies of Peptide / MHC Complexes’1995-1999 Rebecca Romero: ‘Simulation and Chemical Probing of Trinucleotide Repeat DNA’1997-2002 Pornchai Rojsitthisak: ‘The Mechlorethamine C-C Crosslink’1997-2003 Huynh-Hoa Bui: ‘Computer Prediction of Peptide / MHC Complex Structure’1998-2004 Ashutosh Kulkarni: ‘Structure-Function Studies on hPepT1’ (joint with Vincent Lee)1999-2008 Eric Price: ‘Computer Modeling of DNA and RNA’2000-2004 Melina Bayramyan: ‘Analysis of Protein-RNA Complexes’2001-2006 Jennifer Links: ‘Structure-Function Studies on hPepT1’ (joint with Vincent Lee) 2002-2006 Alexandra Schiewe: ‘Structural Prediction of MHC-Peptide-TCR Complexes’ 2004-2010 Brian Sutch: ‘Molecular Design of Nucleic Acid Aptamers’ 2007-2011 Ma’mon Hatmal: ‘Computer Modeling of Spin-labeled Biomolecules’ 2009-2013 Yiyu Li: ‘Computer Modeling of Spin-labeled Proteins’ 2012- Asma El-Magboub: ‘Biopharmaceutical Modeling of Low Solubility Drugs’

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2014- Dab Brill: ‘Solvated Molecular Docking’

Masters2001-2003 Manisha Murthy: ‘Computer Prediction of Nucleic Acid-Protein Interactions’2001-2003 Kaushal Parikh: ‘Computer Prediction of Peptide / MHC Complex Structure’2001-2004 Scott Gleim: ‘Computer Modeling of Transmembrane Protein Structure’2001-2004 Yuancao Cui: ‘Computer Modeling of Transmembrane Protein Structure’2002-2004 Ketan Patel: ‘Computer Modeling of Protein-RNA Association’2006-2009 Nuttapon Jongaroonngamsang: ‘Liquid Chromatographic and Mass Spectrometric

Determinations of Mechlorethamine-DNA Crosslinks’ (joint with Rojsitthisak P)2014-2016 Bianfei Xuan: ‘Computer Modeling of the IAPP Fibril'2015- Billy Viriyabancha: ‘Computer Modeling of Protein-Cyclodextrin Interactions'2015- Yasmin Bahreini: ‘Computer Modeling of Drug-Cyclodextrin Complexes'2016- Jason Giles: ‘Computer Modeling of MHC-Peptide Complexes'

Research Funding

Design and Preclinical Testing of Novel Macrocyclic TACE inhibitors, Co-PI, PI: Michael Selsted USC CTSI, $78,093

Structural Analysis of Protein-Membrane Interaction, Co-PI, PI Ralf Langen, 07/01/01- 01/31/13

PepT1: Structure-Function, Sorting and Modulation, Co-P.I., PI: Vincent H.L. Lee, National Institute for General Medical Sciences, RO1 GM59297-01A1, 3/1/00-2/38/05, $2,028,419.

NIA (P01, Co-PI, PI Dr. Myron Goodman, USC) ‘Triplet Repeat DNA Structure’. 4/1/00-3/31/03, $200,000.

NHLBI P01 (P01 PI Dr. David Warburton, Children’s Hospital, Los Angeles). P.I. of one of 5 grants in the program project ‘Design of Therapeutic Agents for TGF-beta Inhibition’. 5/1/98-4/30/03, $750,000.

James H. Zumberge Interdisplinary Research Fund. ‘The Dynamics of Slipped DNA’. 7/1/02-6/30/03, $37,000.

NATO Travel Award (Dr. Blagbrough IS, University of Bath, UK). ‘Cytotoxic Polyamines Targeted to DNA: Rational Design, Synthesis and Evaluation’ 5/1/97-4/30/98, $5,600.

NCI R29 CA64299-01 ‘Polyamine - DNA Complexes: Structure and Anti-Tumor Mechanisms’ 7/1/94-6/30/99, $346,000 direct costs.

IBM SUR Grant 11/1995 ($20,000 for the purchase of IBM Workstations)

PMA (Pharmaceutical Manufacturers of America) Research Starter Grant. 1/1/94-12/31/95, $25,000 (second year was relinquished upon receipt of R29)

AACP (American Association of Colleges of Pharmacy) New Investigator Award. 1/1/93-12/31/93, $5,000.

NCI Supplemental Funds to IRG-21-33 ‘A Molecular Graphics Core Facility’. 12/1/93-11/30/94, $46,000; 12/1/94-11/30/95, $10,000.

James H. Zumberge Faculty Research and Innovation Fund. ‘Computer Modelling of the B to Z Transition of DNA’. 7/1/93-6/30/95, $22,500.

ACS (American Cancer Society) Pilot Project Award IRG-21-33-06. ‘Computer-Aided Design 17

of a Triplex Forming DNA Alkylating Anti-Tumor Agent’. 1/1/93-12/31/93, $10,000.

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