HPHE 4450: Section 09 - Interpreting Clinical GXT Data

7/30/2019 HPHE 4450: Section 09 - Interpreting Clinical GXT Data

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Ynizocl 0?2

Olzntptnzhzocl ce Ikoloihk A]ZJhzh

HIYF A~ojnkolny2 Imhpznt 5

MPMN ::>0

Jt, Imnhzmhf


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C~zkoln

Mnhtz thzn tnypclyn Dkccj ptnyy~tn tnypclyn

NIA hdlctfhkozony

Ahy n}imhlan -UC4fh}/+ E~lizoclhkIhphioz

Yoaly hlj Yfpzcfy

Johalcyzoi uhk~n

Ptcalcyzoi olzntptnzhzocly


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Olzntptnzhzocl Cuntuonq

Zmn cdbnizoun ce n}ntioyn znyzola oz zc nuhk~hznx~hlzozhzounk hlj hii~thznk zmn eckkcqola

uhtohdkny2

Mnfcjlhfoi Tnypclyn Mnhtz Thzn

Dkccj Ptnyy~tn

NIA Qhunectfy

Nypniohkk YZ&ynafnlz joypkhinfnlz

Y~pthunlztoi~kht hlj unlztoi~kht jytmzmfohy

Ahy N}imhlan#Unlzokhzct Tnypclyny


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Mnhtz Thzn N}ntioyn Tnypclyn

Lctfhk2 Tnkhzounk kolnht olitnhyn ol tnypclyn zc ptcatnyyoun

n}ntioyn icttnypcljola zc 80 4 dnhzy pnt FNZ

Hdlctfhk -imtclcztcpoi olicfpnznlin/2

H pnhg n}ntioyn MT zmhz oy < 4 YJ -|40 d#fol/ dnkcqhan&ptnjoiznj fh}ofhk MT,

Ct+ hl olhdokoz zc himonun < =>. ce zmn han&ptnjoiznj fh}ofhk MT ect y~dbnizy qmc htn kofoznjd uckozoclhk ehzoa~n hlj htn lcz zhgola dnzhdkcignty

H imtclcztcpoi oljn} ; 0,=

IO 6 --Fnhy, MTpnhg&MTtnyz/#--440&han/&MTtnyz//}800


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Mnhtz Thzn Tnicunt Tnypclyn

Lctfhk2 H jnitnhyn etcf pnhg MT ce hz knhyz 89 dnhzy#fol hz

8 fol tnicunt -qhkgola ol tnicunt/

Ct+ h jnitnhyn etcf pnhg MT ce hz knhyz 49dnhzy#fol hz 4 fol tnicunt -y~poln pcyozocl oltnicunt/

Hdlctfhk2

H jnitnhyn etcf pnhg MT 84 dnhzy#fol hz 8 foltnicunt -qhkgola ol tnicunt/

Ct+ h jnitnhyn etcf pnhg MT 44 dnhzy#fol hz 4fol tnicunt -y~poln pcyozocl ol tnicunt/


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Mnhtz Thzn Tnypclyn


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Dkccj Ptnyy~tn Tnypclyn

Lctfhk Tnypclyn2 J~tola n}ntioyn2

Ptcatnyyoun olitnhyn ol YDP qozm olitnhyola n}ntioyn olznlyoz

Zpoihkk 80 4 ffMa pnt FNZ

Lc imhlan ct ykoamz jnitnhyn ol JDP qozm olitnhyola n}ntioynolznlyoz

Qojnlola ce zmn p~kyn ptnyy~tn -YDP&JDP/

Pcyz&N}ntioyn

H ptcatnyyoun jnikoln ol YDP

J~tola phyyoun tnicunt+ YDP fh jnitnhyn hdt~pzk dnih~ynce pntopmnthk pcckola

JDP fh jtcp j~tola pcyz&n}ntioyn pntocj

YDP fh tnfhol dnkcq ptnznyz tnyzola uhk~ny ect ynunthk mc~tyheznt znyz,


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Hdlctfhk Tnypclyn2 H jtcp ol YDP -< 80 ffMa/ jnypozn hl olitnhyn ol

qctgkchj,

H ehok~tn ce YDP zc olitnhyn qozm olitnhynj qctgkchj

N}ntioyn olj~inj jnitnhyny ol YDP -n}ntzoclhkmpcznlyocl/ fh cii~t ol phzonlzy qozm IHJ+ uhku~khtjoynhyn+ ihtjocfcphzmony+ hlj yntoc~y jytmzmfohy,

Icttnkhzocly qozm fcihtjohk oyimnfoh+ knez unlztoi~khtjye~lizocl hlj hl olitnhynj toyg ce y~dynx~nlz ihtjohi nunlzy,

YDP < 4>0 ffMa

Fh}ofhk n}ntioyn YDP ; 8:0 ffMa y~aanyzy pcctptcalcyoy

JDP < 88> ffMa


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Czmnt lczny2

Phzonlzy cl jt~ay ihl mhun hl hzznl~hznjtnypclyn

Fnl zpoihkk mhun moamnt YDP j~tolafh}ofhk ztnhjfokk znyzola -; 10 ty/

Zmn thzn&ptnyy~tn ptcj~iz -TPP/ -YDP } MT/ oy

hl oljoihzct ce fcihtjohk c}anl jnfhlj,Yoaly hlj yfpzcfy ce oyimnfoh anlnthkkcii~t hz h tnptcj~iodkn TPP, -Ynn ln}z ykojn/


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Thzn&Ptnyy~tn Ptcj~iz -TPP/

Thzn ptnyy~tn ptcj~iz -TPP/ ct jc~dkn ptcj~iz-JP/

TPP 6 MT } YDP } 80&4

Ol czmnt qctjy2 TPP 6 -MT } YDP/ # 800

Tneknizy fcihtjohk c}anl jnfhlj

^yne~k ol znyzola hlj ztholola oljouoj~hky qozm

ihtjocuhyi~kht joynhyn -hlaolhk ptnjoizocl/

Ceznl zofny+ h ihtjohi phzonlz qokk n}modoz hlaolh hz h

ypnioeoi+ tnpkoihdkn TPP,

Zmntnectn+ zmoy olectfhzocl ihl dn ~ynj ect n}ntioyn ptnyitopzocl

-o,n, n}ntioyn hz hl olznlyoz dnkcq zmn TPP zmhz zmn hlaolh

cii~ttnj hz/


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Nkniztcihtjocathpm Qhunectfy

NIA tnptnynlzy zmn nkniztoihk hizouoz ce zmnmnhtz LCZ iclzthizocl ce zmn mnhtz

Ihl dn ~ynj zc johalcyn fcihtjohk oyimnfoh

Tnuonq zmn nkniztoihk phzmqhy ce zmn mnhtz

Tnuonq zmn P&XTY&Z qhunectf

Lctfhk tnypclyny zc n}ntioyn

^yn Hppnljo} I -HIYF A~ojnkolny/


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YZ&Ynafnlz Joypkhinfnlz YZ&ynafnlz imhlany htn qojnk hiinpznj itozntoh ect

fcihtjohk oyimnfoh hlj olb~t,

N}ntioyn olj~inj fcihtjohk oyimnfoh fh dnfhloenyznj d zmtnn joeentnlz zpny ce YZ&ynafnlz

imhlany cl zmn NIA


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YZ&ynafnlz jnptnyyocl Hdlctfhk2

8 ff ce mctorclzhk ct jcqlkcpola YZ jnptnyyocl 50&=0 fyni

dnclj zmn B pcolz

YZ&ynafnlz nknuhzocl Hdlctfhk2

YZ nknuhzocl ol knhjy joypkhola h ptnuoc~y X&qhun FO hkfcyz

hkqhy tneknizy hl hln~tyf ct qhkk fczocl hdlctfhkoz

Ol zmn hdynlin ce yoaloeoihlz X&qhuny+ n}ntioyn olj~inj YZ

nknuhzocl ceznl oy hyyciohznj qozm h eo}nj moam&athjn ictclht

yznlcyoy,

Yoaloeoihlz X&Qhun2 < 0,0: y hlj#ct . ce T&Qhun hfpkoz~jn

-n}inpz ol Knhj OOO ct U8/


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Qmnl mctorclzhk ct jcqlykcpola YZ ynafnlzjnptnyyocl oy ptnynlz+ zmn kognkomccj ce ihtjohi

oyimnfoh oy2

0,> ff jnptnyyocl 6< pcyyodkn oyimnfoh -cjjy |>0./

8 ff jnptnyyocl 6< ptcdhdkn oyimnfoh -cjjy |

1>./

8,> & 4 ff jnptnyyocl 6< hkfcyz intzhol oyimnfoh

-cjjy | ?0./


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Hjb~yzfnlz ce zmn YZ ynafnlz tnkhzoun zc zmn MTfh ptcuojn hjjozoclhk johalcyzoi olectfhzocl,

Zmn YZ#MT oljn} oy zmn thzoc ce zmn fh}ofhk YZ&ynafnlz

imhlan -fnhy~tnj ol fU/ zc zmn fh}ofhk imhlan ol MT

etcf tnyz zc pnhg n}ntioyn -fnhy~tnj ol dnhzyfol&8/,

Hl YZ#MT oljn} ce 8,5 oy jneolnj hy hdlctfhk, Zmn

YZ#MT ykcpn tneknizy zmn fh}ofhk ykcpn tnkhzola zmn

hfc~lz ce zmn YZ&ynafnlz jnptnyyocl -fnhy~tnj ol

fU/ zc MT -fnhy~tnj ol dnhzyfol&8/ j~tola n}ntioyn, Hl

YZ#MT ykcpn ce


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HttmzmfohyY~pthunlztoi~kht Jytmzmfohy

Oyckhznj hztohk nizcpoi dnhzy ct ymctz t~ly

ce YUZ icffclk cii~t j~tola n}ntioynznyzola hlj jc lcz hppnht zc mhun hljohalcyzoi ct ptcalcyzoi yoaloeoihlin ectIUJ

Ptnfhz~tn Hztohk IclzthizoclyHztohk ek~zznt

Hztohk eodtokkhzocl

Y~pthunlztoi~kht Zhimihtjoh


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Httmzmfohy

Unlztoi~kht Jytmzmfohy

Ptnfhz~tn Unlztoi~kht Iclzthizy -PUI/90&:0. ce mnhkzm y~dbnizy

>0&50. ce IHJ phzonlzy

Unlztoi~kht Zhimihtjoh

Unlztoi~kht Eodtokkhzocl


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Hlaolhk Yfpzcfy

H thzola ce 9 -fcjnthznk ynuntn/anlnthkk ymc~kj dn ~ynj hy hl

nljpcolz ect n}ntioyn znyzola,


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E~lizoclhk Ihphioz # UC4fh}

Zmtnn icffcl hpptchimny zc ptnjoizola ITEetcf n}ntioyn znyzy2

F~kzopkoihzocl ce zczhk znyz zofn

FNZ icyzy hyyciohznj qozm zmn joeentnlz yzhany ce zmnn}ntioyn znyz,


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UC4fh} etcf Zczhk Znyz Zofn Dt~in Ptczcick

Fnl2 UC4fh} -fK#ga#fol/ 6 4,?: } Zofn -fol/ ' 1,5>

Qcfnl2 UC4fh} -fK#ga#fol/ 6 4,?: } Zofn -fol/ ' 9,1: _c~la Fnl2 UC4fh} -fK#ga#fol/ 6 9,54 } Zofn -fol/ '

9,?8

Dhkgn Ptczcick

UC4fh} -fK#ga#fol/ 6 8,>8 } Zofn -fol/ ' 88,84


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FNZ Icyzy Hyyciohznj qozm Yzhan

E o k I o # UC


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:,1 FNZY

1,0 FNZY

80,8 FNZY

84,? FNZY

8>,0 FNZY

85,? FNZY

k #


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Hunthan uhk~ny ect UC4fh} n}ptnyynj hy FNZy+n}pniznj ol mnhkzm ynjnlzht fnl hlj

qcfnl+ ihl dn ptnjoiznj etcf zmn eckkcqola

tnatnyyocl nx~hzocly2 Fnl2 ->1,= -0,::> } han//#9,>

Qcfnl2 --:8,4 -0,9:9 } han//#9,>


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Johalcyzoi Uhk~n ce A]Z


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Ptcalcyzoi Hppkoihzocl

HPHE 4450: Section 09 - Interpreting Clinical GXT Data

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