HOXA9 and its Role in Acute Myeloid Leukemia
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HOXA9 and its Role in Acute Myeloid
LeukemiaBrent Hoffman
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HOXA9 is one of the HOX transcription factors regulating Anterior to Posterior patterning in early development
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HOXA9 regulates bone marrow stem cell proliferation and cells differentiate as
HOXA9 expression decreases
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HOXA9 -/- bone marrow cells showed inhibited ability to repopulate in vitro after
hematopoietic stress
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Acute Myeloid Leukemia is a cancer of the bone marrow affecting white blood cell proliferation and differentiation
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In AML, a translocation joinsHOXA9 to NUP98
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Fusion of the NUP98 gene to HOXA9 induces AML in mice cells
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Current treatment for AML is divided into two phases: remission induction and post-remission therapy
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References• “Acute Myelogenous Leukemia (AML).” Mayoclinic. Mayo Clinic Staff, 5 Sept. 2012. Web. 4-4/13.
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• “Adult Acute Myeloid Leukemia Treatment (PDQ®).” National Cancer Institute . Web. 11–4 2012. <http://www.cancer.gov/cancertopics/pdq/treatment/adultAML/Patient/page3>.
• “Algorithmic and Topological Body Plans.” Web. 11–4 2012. <http://www.19thpsalm.org/Ch09/Algorithm-Topology.html>.• Gough, S. M., Slape, C. L., & Aplan, P. D. (2011). NUP98 gene fusions and hematopoietic and new biologic insights
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• Hematopoeisis from Multipotent Stem Cells. (2012). Retrieved from http://www.ebioscience.com/resources/pathways/hematopoiesis-from-multipotent-stem-cells.htm
• “Hematopoietic Stem Cell Transplantation (HSCT) and Cerebral ALD.” Web. 4–11 2013. <http://www.x-ald.nl/treatment-options/hsct/>.
• Kroon, Evert et al. “NUP98–HOXA9 Expression in Hemopoietic Stem Cells Induces Chronic and Acute Myeloid Leukemias in Mice.” The EMBO Journal 20.3 (2001): 350–361. NCBI. Web. 4–11 2013. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133485/>.
• Lawrence, Jeffrey H et al. “Loss of Expression of the Hoxa-9 Homeobox Gene Impairs the Proliferation and Repopulating Ability of Hematopoietic Stem Cells.” Blood 106.12 (2005): 3988–3994. Print.
• “Typical Treatment of Acute Myeloid Leukemia (except Promyelocytic M3).” American Cancer Society. Web. 11-4/13. <http://www.cancer.org/cancer/leukemia-acutemyeloidaml/detailedguide/leukemia-acute-myeloid-myelogenous-treating-typical-treatment-of-aml>.