* of the same product in the same size at one time

This card is issued by MetaBank®, Member FDIC, pursuant to a license from Visa U.S.A. Inc.MANUFACTURER’S COUPON | ORIGINAL RECEIPT REQUIRED | FOR MAIL-IN REBATE REDEEMABLE ONLY ON PRODUCT BOUGHT AT YOUR VETERINARY CLINIC EXPIRES 12/31/2017 | MAY NOT BE COMBINED WITH ANY OTHER OFFER

IMPORTANT SAFETY INFORMATION: NexGard is for use in dogs only. The most frequently reported adverse reactions included pruritus, vomiting, dry/fl aky skin, diarrhea, lethargy, and lack of appetite. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures. For more information, see full prescribing information or visit www.NexGardForDogs.com.

When you Buy 12 Doses of a HEARTGARD

®

(ivermectin) Brand Product* and 12 Doses of a MERIAL

®

fl ea & tick control product*

Original receipt must be included and dated on or before 12/31/2017. Rebate request must be received on or before 3/1/2018. Merial reserves the right to amend, substitute, or withdraw this offer at any time without notice. Receipts must indicate a HEARTGARD Brand Product 12-Pack purchase and 12 doses of FRONTLINE Brand Product or NexGard. Offer may be redeemed only by pet owner. Good only in continental U.S. and Hawaii. Void where prohibited or restricted by law. All federal, state and local laws and regulations apply. This form must accompany request; reproductions or other copies will not be accepted. Fraudulent submission could result in

Federal prosecution under mail fraud statutes (Title 18, United States Code, Section 1341 and 1342) and applicable state laws. May not be combined with any other offer.

®MERIAL, FRONTLINE, NexGard, HEARTGARD, and the Dog & Hand logo are registered trademarks, and TMFRONTLINE VET LABS is a trademark, of Merial. ©2017 Merial, Inc., Duluth, GA. All rights reserved. ComboCoupon50 (01/17).

ORIGINAL ITEMIZED RECEIPT MUST ACCOMPANY FORM AND BE DATED ON OR BEFORE 12/31/2017. ONE COUPON REQUIRED FOR EVERY JOINT PURCHASE OF 12 HEARTGARD BRAND PRODUCT DOSES AND 12 FLEA & TICK PRODUCT DOSES. PLEASE ALLOW 6 TO 8 WEEKS FOR DELIVERY. REBATE REQUEST MUST BE RECEIVED ON

OR BEFORE 03/01/2018. OFFER CANNOT BE COMBINED WITH ANY OTHER COUPON OFFER.

PET OWNER, PLEASE PRINT THE FOLLOWING INFORMATION:

Complete the following for your $50 Visa prepaid card:

� HEARTGARD® Plus (ivermectin/pyrantel)� HEARTGARD (ivermectin)

� FRONTLINE Brand Product For Dogs� FRONTLINE Brand Product For Cats

Name: ______________________________________________________________________________

Address: ____________________________________________________________________________

City: _________________________________________State: ____ Zip: __________________________

Email: _______________________________________________________________________________

Pet’s Name: ___________________________________Pet’s Birthday (MM/DD/YY) ____ / ____ / ____

Merial Account #: _____________________________________________________________________

Veterinary Hospital: ____________________________________________________________________

Address: ____________________________________________________________________________

City: __________________________________________________State: _______Zip: _______________

MERIAL® Rewards #: ________________________ MERIAL Rewards Name: __________________

FOR VETERINARY CLINIC USE ONLY:

Redeem this coupon by returning it to:

MerialProgram HeadquartersPO Box 540069El Paso, TX 88554-0069 PLEASE ALLOW 6-8 WEEKS FOR DELIVERY.

Merial respects your privacy. We will not share, sell or rent the information you provide on this form. By providing your email address, you agree to receive special coupons, offers and information from Merial.Product must be dispensed on or before 12/31/2017 | Rebate request must be received on or before 3/1/2018

HOW TO GET YOUR $50 MERIAL® BRAND PRODUCTS VISA® PREPAID CARD

STAMP CLINIC INFORMATION HERE

17-96788

17-96789� NexGard® (afoxolaner)

RECEIVE A $50 REBATE

CAU

TIO

N: F

eder

al (U

SA) l

aw re

stric

ts th

is d

rug

to u

se b

y or

on

the

orde

r of a

lice

nsed

ve

terin

aria

n.D

escr

iptio

n:N

exGa

rd®

(afo

xola

ner)

is a

vaila

ble

in fo

ur s

izes

of b

eef-fl

avor

ed, s

oft c

hew

able

s fo

r or

al a

dmin

istra

tion

to d

ogs

and

pupp

ies

acco

rdin

g to

thei

r wei

ght.

Each

che

wab

le

is fo

rmul

ated

to p

rovi

de a

min

imum

afo

xola

ner d

osag

e of

1.1

4 m

g/lb

(2.5

mg/

kg).

Afox

olan

er h

as th

e ch

emic

al c

ompo

sitio

n 1-

Nap

htha

lene

carb

oxam

ide,

4-[5

- [3-

chlo

ro-5

-(tr

ifluo

rom

ethy

l)-ph

enyl

]-4, 5

-dih

ydro

-5-(t

rifluo

rom

ethy

l)-3-

isox

azol

yl]-N

-[2-o

xo-2

-[(2,

2,2-

triflu

oroe

thyl

)am

ino]

ethy

l. In

dica

tions

:N

exGa

rd k

ills

adul

t flea

s an

d is

indi

cate

d fo

r the

trea

tmen

t and

pre

vent

ion

of fl

ea

infe

stat

ions

(Cte

noce

phal

ides

felis

), an

d th

e tre

atm

ent a

nd c

ontro

l of B

lack

-legg

ed

tick

(Ixod

es sc

apul

aris)

, Am

eric

an D

og ti

ck (D

erm

acen

tor v

aria

bilis

), Lo

ne S

tar t

ick

(Am

blyo

mm

a am

erica

num

), an

d Br

own

dog

tick

(Rhi

pice

phal

us sa

ngui

neus

) inf

esta

tions

in

dog

s an

d pu

ppie

s 8

wee

ks o

f age

and

old

er, w

eigh

ing

4 po

unds

of b

ody

wei

ght o

r gr

eate

r, fo

r one

mon

th.

Dos

age

and

Adm

inis

trat

ion:

Nex

Gard

is g

iven

ora

lly o

nce

a m

onth

, at t

he m

inim

um d

osag

e of

1.1

4 m

g/lb

(2.5

mg/

kg).

Dos

ing

Sche

dule

:

Nex

Gard

can

be

adm

inis

tere

d w

ith o

r with

out f

ood.

Car

e sh

ould

be

take

n th

at th

e do

g co

nsum

es th

e co

mpl

ete

dose

, and

trea

ted

anim

als

shou

ld b

e ob

serv

ed fo

r a fe

w m

inut

es

to e

nsur

e th

at p

art o

f the

dos

e is

not

lost

or r

efus

ed. I

f it i

s su

spec

ted

that

any

of t

he

dose

has

bee

n lo

st o

r if v

omiti

ng o

ccur

s w

ithin

two

hour

s of

adm

inis

tratio

n, re

dose

with

an

othe

r ful

l dos

e. If

a d

ose

is m

isse

d, a

dmin

iste

r Nex

Gard

and

resu

me

a m

onth

ly d

osin

g sc

hedu

le.

Flea

Trea

tmen

t and

Pre

vent

ion:

Trea

tmen

t with

Nex

Gard

may

beg

in a

t any

tim

e of

the

year

. In

area

s w

here

flea

s ar

e co

mm

on y

ear-r

ound

, mon

thly

trea

tmen

t with

Nex

Gard

sho

uld

cont

inue

the

entir

e ye

ar

with

out i

nter

rupt

ion.

To

min

imize

the

likel

ihoo

d of

flea

rein

fest

atio

n, it

is im

porta

nt to

trea

t all

anim

als

with

in

a ho

useh

old

with

an

appr

oved

flea

con

trol p

rodu

ct.

Tick

Tre

atm

ent a

nd C

ontro

l:Tr

eatm

ent w

ith N

exGa

rd m

ay b

egin

at a

ny ti

me

of th

e ye

ar (s

ee E

ffect

iven

ess)

.Co

ntra

indi

catio

ns:

Ther

e ar

e no

kno

wn

cont

rain

dica

tions

for t

he u

se o

f Nex

Gard

.W

arni

ngs:

Not

for u

se in

hum

ans.

Kee

p th

is a

nd a

ll dr

ugs

out o

f the

reac

h of

chi

ldre

n. In

cas

e of

ac

cide

ntal

inge

stio

n, c

onta

ct a

phy

sici

an im

med

iate

ly.

Prec

autio

ns:

The

safe

use

of N

exGa

rd in

bre

edin

g, p

regn

ant o

r lac

tatin

g do

gs h

as n

ot b

een

eval

uate

d.

Use

with

cau

tion

in d

ogs

with

a h

isto

ry o

f sei

zure

s (s

ee A

dver

se R

eact

ions

).A

dver

se R

eact

ions

:In

a w

ell-c

ontro

lled

US fi

eld

stud

y, w

hich

incl

uded

a to

tal o

f 333

hou

seho

lds

and

615

treat

ed d

ogs

(415

adm

inis

tere

d af

oxol

aner

; 200

adm

inis

tere

d ac

tive

cont

rol),

no

serio

us

adve

rse

reac

tions

wer

e ob

serv

ed w

ith N

exGa

rd.

Over

the

90-d

ay st

udy p

erio

d, a

ll ob

serv

atio

ns o

f pot

entia

l adv

erse

reac

tions

wer

e re

cord

ed. T

he m

ost f

requ

ent r

eact

ions

repo

rted

at a

n in

ciden

ce o

f > 1

% w

ithin

any

of t

he

thre

e m

onth

s of o

bser

vatio

ns a

re p

rese

nted

in th

e fo

llow

ing

tabl

e. T

he m

ost f

requ

ently

re

porte

d ad

vers

e re

actio

n w

as vo

miti

ng. T

he o

ccur

renc

e of

vom

iting

was

gen

eral

ly se

lf-lim

iting

and

of s

hort

dura

tion

and

tend

ed to

dec

reas

e w

ith su

bseq

uent

dos

es in

bot

h gr

oups

. Five

trea

ted

dogs

exp

erie

nced

ano

rexia

dur

ing

the

stud

y, an

d tw

o of

thos

e do

gs

expe

rienc

ed a

nore

xia w

ith th

e fir

st d

ose

but n

ot su

bseq

uent

dos

es.

Tabl

e 1:

Dog

s W

ith A

dver

se R

eact

ions

.

1 Num

ber o

f dog

s in

the

afox

olan

er tr

eatm

ent g

roup

with

the

iden

tified

abn

orm

ality

.2 N

umbe

r of d

ogs

in th

e co

ntro

l gro

up w

ith th

e id

entifi

ed a

bnor

mal

ity.

In th

e US

fiel

d st

udy,

one

dog

with

a h

isto

ry o

f sei

zure

s ex

perie

nced

a s

eizu

re o

n th

e sa

me

day

afte

r rec

eivi

ng th

e fir

st d

ose

and

on th

e sa

me

day

afte

r rec

eivi

ng th

e se

cond

do

se o

f Nex

Gard

. Thi

s do

g ex

perie

nced

a th

ird s

eizu

re o

ne w

eek

afte

r rec

eivi

ng th

e th

ird

dose

. The

dog

rem

aine

d en

rolle

d an

d co

mpl

eted

the

stud

y. A

noth

er d

og w

ith a

his

tory

of

sei

zure

s ha

d a

seizu

re 1

9 da

ys a

fter t

he th

ird d

ose

of N

exGa

rd. T

he d

og re

mai

ned

enro

lled

and

com

plet

ed th

e st

udy.

A th

ird d

og w

ith a

his

tory

of s

eizu

res

rece

ived

N

exGa

rd a

nd e

xper

ienc

ed n

o se

izure

s th

roug

hout

the

stud

y.

To re

port

susp

ecte

d ad

vers

e ev

ents

, for

tech

nica

l ass

ista

nce

or to

obt

ain

a co

py o

f the

M

SDS,

con

tact

Mer

ial a

t 1-8

88-6

37-4

251

or w

ww

.mer

ial.c

om/N

exGa

rd. F

or a

dditi

onal

in

form

atio

n ab

out a

dver

se d

rug

expe

rienc

e re

porti

ng fo

r ani

mal

dru

gs, c

onta

ct F

DA a

t 1-

888-

FDA-

VETS

or o

nlin

e at

http

://w

ww

.fda.

gov/

Anim

alVe

terin

ary/

Safe

tyHe

alth

.M

ode

of A

ctio

n:Af

oxol

aner

is a

mem

ber o

f the

isox

azol

ine

fam

ily, s

how

n to

bin

d at

a b

indi

ng s

ite to

in

hibi

t ins

ect a

nd a

carin

e lig

and-

gate

d ch

lorid

e ch

anne

ls, i

n pa

rticu

lar t

hose

gat

ed

by th

e ne

urot

rans

mitt

er g

amm

a-am

inob

utyr

ic a

cid

(GAB

A), t

here

by b

lock

ing

pre-

and

po

st-s

ynap

tic tr

ansf

er o

f chl

orid

e io

ns a

cros

s ce

ll m

embr

anes

. Pro

long

ed a

foxo

lane

r-in

duce

d hy

pere

xcita

tion

resu

lts in

unc

ontro

lled

activ

ity o

f the

cen

tral n

ervo

us s

yste

m a

nd

deat

h of

inse

cts

and

acar

ines

. The

sel

ectiv

e to

xici

ty o

f afo

xola

ner b

etw

een

inse

cts

and

acar

ines

and

mam

mal

s m

ay b

e in

ferre

d by

the

diffe

rent

ial s

ensi

tivity

of t

he in

sect

s an

d ac

arin

es’ G

ABA

rece

ptor

s ve

rsus

mam

mal

ian

GABA

rece

ptor

s.Ef

fect

iven

ess:

In a

wel

l-con

trolle

d la

bora

tory

stud

y, Ne

xGar

d be

gan

to ki

ll fle

as fo

ur h

ours

afte

r ini

tial

adm

inist

ratio

n an

d de

mon

stra

ted

>99%

effe

ctive

ness

at e

ight

hou

rs. I

n a

sepa

rate

wel

l-co

ntro

lled

labo

rato

ry st

udy,

NexG

ard

dem

onst

rate

d 10

0%ef

fect

ivene

ss a

gain

st a

dult

fleas

24

hour

s pos

t-inf

esta

tion

for 3

5 da

ys, a

nd w

as ≥

93%

ef

fect

ive a

t 12

hour

s pos

t-inf

esta

tion

thro

ugh

Day 2

1, a

nd o

n Da

y 35.

On

Day 2

8, N

exGa

rd

was

81.

1% e

ffect

ive 1

2 ho

urs p

ost-i

nfes

tatio

n. D

ogs i

n bo

th th

e tre

ated

and

cont

rol g

roup

s th

at w

ere

infe

sted

with

flea

s on

Day -

1 ge

nera

ted

flea

eggs

at 1

2- a

nd 2

4-ho

urs p

ost-

treat

men

t (0-

11 e

ggs a

nd 1

-17

eggs

in th

e Ne

xGar

d tre

ated

dog

s, an

d 4-

90 e

ggs a

nd 0

-118

eg

gs in

the

cont

rol d

ogs,

at 1

2- a

nd 2

4-ho

urs,

resp

ectiv

ely).

At s

ubse

quen

t eva

luat

ions

pos

t-in

fest

atio

n, fl

eas f

rom

dog

s in

the

treat

ed g

roup

wer

e es

sent

ially

una

ble

to p

rodu

ce a

ny e

ggs

(0-1

egg

s) w

hile

flea

s fro

m d

ogs i

n th

e co

ntro

l gro

up co

ntin

ued

to p

rodu

ce e

ggs (

1-14

1 eg

gs).

In a

90-

day U

S fie

ld st

udy c

ondu

cted

in h

ouse

hold

s with

exis

ting

flea

infe

stat

ions

of v

aryin

g se

verit

y, th

e ef

fect

ivene

ss o

f Nex

Gard

aga

inst

flea

s on

the

Day 3

0, 6

0 an

d 90

visit

s com

pare

d w

ith b

asel

ine

was

98.

0%, 9

9.7%

, and

99.

9%, r

espe

ctive

ly.

Colle

ctive

ly, th

e da

ta fr

om th

e th

ree

stud

ies (

two

labo

rato

ry a

nd o

ne fi

eld)

dem

onst

rate

that

Ne

xGar

d kil

ls fle

as b

efor

e th

ey ca

n la

y egg

s, th

us p

reve

ntin

g su

bseq

uent

flea

infe

stat

ions

af

ter t

he st

art o

f tre

atm

ent o

f exis

ting

flea

infe

stat

ions

. In

wel

l-con

trolle

d la

bora

tory

stud

ies,

NexG

ard

dem

onst

rate

d >9

7% e

ffect

ivene

ss

agai

nst D

erm

acen

tor v

aria

bilis

, >94

% e

ffect

ivene

ss a

gain

st Ix

odes

scap

ular

is, a

nd >

93%

ef

fect

ivene

ss a

gain

st R

hipi

ceph

alus

sang

uine

us, 4

8 ho

urs p

ost-i

nfes

tatio

n fo

r 30

days

. At

72 h

ours

pos

t-inf

esta

tion,

Nex

Gard

dem

onst

rate

d >9

7% e

ffect

ivene

ss a

gain

st A

mbl

yom

ma

amer

icanu

m fo

r 30

days

.A

nim

al S

afet

y:In

a m

argi

n of

safe

ty st

udy,

NexG

ard

was

adm

inist

ered

ora

lly to

8 to

9-w

eek-

old

Beag

le

pupp

ies a

t 1, 3

, and

5 ti

mes

the

max

imum

exp

osur

e do

se (6

.3 m

g/kg

) for

thre

e tre

atm

ents

ev

ery 2

8 da

ys, f

ollo

wed

by t

hree

trea

tmen

ts e

very

14

days

, for

a to

tal o

f six

treat

men

ts. D

ogs

in th

e co

ntro

l gro

up w

ere

sham

-dos

ed. T

here

wer

e no

clin

ically

-rele

vant

effe

cts r

elat

ed

to tr

eatm

ent o

n ph

ysica

l exa

min

atio

n, b

ody w

eigh

t, fo

od co

nsum

ptio

n, cl

inica

l pat

holo

gy

(hem

atol

ogy,

clini

cal c

hem

istrie

s, or

coag

ulat

ion

test

s), g

ross

pat

holo

gy, h

istop

atho

logy

or

orga

n w

eigh

ts. V

omiti

ng o

ccur

red

thro

ugho

ut th

e st

udy,

with

a si

mila

r inc

iden

ce in

the

treat

ed

and

cont

rol g

roup

s, in

cludi

ng o

ne d

og in

the

5x g

roup

that

vom

ited

four

hou

rs a

fter t

reat

men

t.In

a w

ell-c

ontro

lled

field

stu

dy, N

exGa

rd w

as u

sed

conc

omita

ntly

with

oth

er

med

icat

ions

, suc

h as

vac

cine

s, a

nthe

lmin

tics,

ant

ibio

tics

(incl

udin

g to

pica

ls),

ster

oids

, N

SAID

S, a

nest

hetic

s, a

nd a

ntih

ista

min

es. N

o ad

vers

e re

actio

ns w

ere

obse

rved

from

the

conc

omita

nt u

se o

f Nex

Gard

with

oth

er m

edic

atio

ns.

Stor

age

Info

rmat

ion:

Stor

e at

or b

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size

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3, 2

8.3,

68

or 1

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ach

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size

is a

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in c

olor

-cod

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, 3 o

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: Fro

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Inc.

Dulu

th, G

A 30

096-

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USA

Mad

e in

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®N

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a re

gist

ered

trad

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k, a

nd TM

FRON

TLIN

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T LA

BS is

a tr

adem

ark,

of

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l. Al

l rig

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.

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Rev.

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s

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(mg)

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4.0

to 10

.0 lbs

. 11

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e

10.1

to 24

.0 lbs

. 28

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e

24.1

to 60

.0 lbs

. 68

On

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60.1

to 12

1.0 lb

s. 13

6 On

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Over

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Admi

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appr

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f che

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N1 %

(n=4

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N2 %

(n=2

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17

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