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A global leader in the pursuit of human well-being and health through genome-based personalized medicine
THERAGEN ETEX
Table of Contents
About UsⅠ Vision and Mission
Collaboration
Business Strategy and Network
Collaboration and Network
Service Portfolio
Research Performance
About Our People
Status of Equipment
Server Resources
Certification Program
History
Research and Resources
Ⅲ
Ⅱ Services TotalOmics
Oncomics
GenomeReport
Array
HelloGene
GeneStyle
Pharmaceutical Division
- Etex Pharma
Subsidiary Companies
- MedPacto
- GenomeCare
- LeadPharm
- TheragenHealthcare
01 THERAGEN ETEX_Genomic innovations, Healthcare solutions
Greetings
THERAGEN ETEX_Genomic innovations, Healthcare solutions 02
Greetings
Theragen Etex is a genome specialized company
that carries forward the development of precision
medicine and new drugs based on cutting-edge
genome decoding technology and bioinformation.
Theragen Etex's genome analysis technology has
been proven through numerous articles published in
leading scientific journals.
We are providing research services for various spe-
cies using our own technology and individual
customized gene analysis services such as the
disease susceptibility of human beings, physical
characteristics, response to drugs.
Based on this gene analysis technology, Theragen
Etex is making every effort to realize customized
medicine and become a global leader in the pursuit
of human welfare and health.
03 THERAGEN ETEX_Genomic innovations, Healthcare solutions
FOUNDER & VICE CHAIRMAN
CEO & PRESIDENT
Seong-Jin Kim
Tae-Soon Hwang
THERAGEN ETEX_Genomic innovations Healthcare solutions 04THERAGEN ETEX_Genomic innovations, Healthcare solutions 04
I About Us
Theragen Etex is a company specializing in the development of diagnostic solutions and new drugs using genome
analysis information. Based on individual gene analysis, the Genome Research Center identifies diverse genome
information in a specific disease and is developing new customized drugs based on this at the New Drug Research
Center. Theragen Etex is making every effort for the development of customized medicines specialized for individu-
als by analyzing and data basing the genome of diverse species and finding new drug target materials through the
discovery of genetic change information related to the diseases (genetic disease, cancer). Theragen Etex is the fifth
company in the world that identified human genome maps and has the best genome analysis technology in the
industry. In June 2013, we identified the world's first Korean gastric cancer gene. In January 2014, we were recog-
nized as the world's first to complete the map of the Minke whale genome, thereby decorating the cover of Nature
Genetics. In addition, we began our first step into the overseas market with an individual genome analysis service
(Hellogene) contract with UNIMEX in The Philippines in 2011. We completed an agreement with the Hwangseok
Health Examination Center to enter into the individual genome analysis service in China. Through this, we are
establishing a foothold for the advancement into the global market by constituting Asian genetic information and
networks such as the establishment of a local corporation to expand into other countries (Asia including the Philip-
pines and Thailand) in the future.
The SeviceProvider on
Genome Research
Sequencing
Array Bioinformatics
Software&
Server
B2BNBM
Data-driven
4th industry
TreatmentDiagnosis
05 THERAGEN ETEX_Genomic innovations, Healthcare solutions
01 Vision and Mission
02 Collaboration
Theragen Etex Bio Laboratory is a "global leader in the pursuit of human wealth and health through
genome based customized medicine" and is practicing the following missions through genome based
total services.
Product development through base clinical research
Customer tailored services through genome data solutions
Promotion of health and welfare through the analysis of human genome data
1
2
3
Bio InstituteGenome research services
Individual gene analysis services
Software and server sales
R&D of diagnostic solution
Pharmaceutical DivisionSynthetic new drugs and bio new drugs
Manufacture and sale of improved new drugs
(Respiratory, gastrointestinal
circulatory diseases)
Genome Care Co. LtdNoninvasive antenatal congenital anomaly test
LeadPharm Co., LtdPharmacy chain business and license business
MedPacto, Inc. New drug development
Theragene Health Care, Inc. Medical supplies manufacturing and distribution
Theragen Etex Subsidiary companies
03 Business Strategy
THERAGEN ETEX_Genomic innovations, Healthcare solutions 06
Based on genome analysis technologies and solutions, Theragen Etex providesnew drug development, pharmaceutical business, clinical services, and healthcareservices. We are expanding our network to lead the era of precision medicine witha pipeline that incorporates open innovation between group companies.
New drug development
MedPacto, Inc.
Sales anddistribution
LeadPharm Co., Ltd
New drugmanufacturing
Theragen Etex,Pharmaceutical
Division Inc.
Clinical service
Genome Care Co., Ltd.
Health care
TheragenHealth Care, Inc.
Genome based R&D
Theragen Etex Bio Institute
Restructuring
& R
einforcement
04 Strategic Partnership and Network
07 THERAGEN ETEX_Genomic innovations, Healthcare solutions
Over 650 medical institutions
(as of 2017)
Domestic Partners
As of 2017, we provide services to more than 650 medical institutions. Based on the technology of genome analysis of domestic partner institutions, we are making efforts to provide better genome information services as well as new product development by carrying out joint development with research institutes and government agencies. In addi-tion, Theragen Etex aims to contribute to the improvement of human welfare through genome innovation by establishing strategic partnerships, based on trust, with overseas global companies.
THERAGEN ETEX_Genomic innovations, Healthcare solutions 08
Based on infrastructure, Theragen Etex is expanding its business into each country. Through many years of transactions, we have steadily established ourselves as a reliable company from partner companies. With diverse genome analysis services, we connect customers and companies around the world and provide services under stable cooperation.
05 Service Portfolio
service portfolio
Research Centered Service Commercial Service
Theragen DXHellogene
TotalOmics OncomicsAdvanced Analysis Array Service
New Drug Development
● Direct-to-consumer service
● Skin
● Hair
● Fitness
● Advanced BI
● BIT system, DB
● Molecular sarcoma
●Genome report
● Cancer
● Common disease
Platinum Lite●
● Noble
● Kids
● Metabolic syndrome
● SNP Chip
● Customized Chip
● Korean SNP Chip
● GWAS Support
● Exome Sequencing
● Transcriptome Sequencing
● Whole Genome Sequencing
● Meta Genome Sequencing
● Epigenome Sequencing
● De novo
● Cancer Panel
● Liquid Biopsy
● BRCAinside
● Genomom
● Cancerinside
● OncoChaser
● Marker Development
● Preclinical Support
● Clinical Support
● Companion diagnostics
Hellogene Dental●
● Platinum
GeneStyle
Overseas Partnership
09 THERAGEN ETEX_Genomic innovations, Healthcare solutions
The TotalOmics solution is a next-generation genome research service that provides sequence decoding and an analysis solution for all genome areas. Theragen Etex pro-vides genome decoding and analysis for the whole genome, transcriptome, epigenome and exome with professional skills based on the experience of the first Korean genome decoding and analysis. Leading genome (De novo) or reference-based genome decod-ing is all possible, including genome decoding and analysis for a variety of life forms, such as humans, many other animals/plants, and bacteria with high GC content rates.
Methyl decoding
Bisulfite decoding
MeDIP decoding
ChIP decoding
Transcriptome decoding
Small RNA decoding
Bacteria genome decoding
Meta-genomics decoding
Fungi(mildew, mycete) decoding
Meta 16rDNA decoding
Genome•Exome decoding/analysis products
Microorganism genome decoding/analysis products
Transcriptome decoding/analysis products
Epigenome decoding/analysis products
WGS
De novo decoding
Exome decoding
Target Area decoding
II Service 01 TotalOmics: Next generation Base Sequence Analysis Service www.theragenetex.com/kr/bio/services/totalomics/
THERAGEN ETEX_Genomic innovations, Healthcare solutions 10
02 Oncomics: Cancer gene analysis service www.theragenetex.com/kr/bio/services/oncomics/
Since many known cancers are highly associated with genetic mutations, the identification of mutations through current genome analysis has become an important method for diagnosis and therapy. Oncomics is a service that decodes using the next generation base sequence by utilizing a small amount of blood or cancer tissue and then accurately analyzing the mutation. Through testing, a prescribed targeted medicine will minimize the side effects of the drug, and thereby increase the success rate of cancer treatment.
| Periodic Precision Inspection of Cancer |
DiagnosisEarly detection of cancer
Simple blood test allows early detection of cancer
Treatment
Proceed with therapeutic intervention by classifying patients according to genetic variation.
Customized treatment with consideration of drug resistance is possible. Optimize the treatment effect customized to patients and minimize side effects.
RecurrenceTrack whether cancer recurs
Precise monitoring of recurrent cancer by periodic blood tests after treatment
Theragen Etex Cancer Analysis Service
Oncomics·Clinical study using cancer panel
Liquid Biopsy·Cancer analysis using cancer DNA
in blood
BRCAinside·Breast Cancer/Ovary Cancer Inspection Service
OncoChaser·Non-invasive cancer recurrence check service
CancerInside·Cancer family history screening service
NGS Clinical Research Domestic No.1 NGS Clinical Research Approval from Ministry of Food and Drug SafetyUsing NGS (Next Generation Sequence) devices, which were used for research purposes, it is the
first laboratory in Korea to be certified as a food service place. We utilize the decoding and analysis
technology accumulated over many years for clinical use.
In accordance with Article 20 (2) of the Regulations on Medical Device Permits, Notifications
Research Diagnosis
11 THERAGEN ETEX_Genomic innovations, Healthcare solutions
04 Array: Genome Chip Analysis
The microarray is a technology that can identify thousands to tens of thou-sands of genes with a single experiment and is used for gene function prediction, disease classification, and diagnosis. Increases in the occur-rence rate of hereditary diseases, awareness of customized medical treat-ment, demand for drug genomics in drug discovery, and use of livestock are driving market growth. In addition to the chips commercialized with many experiments and analysis experiences, we are providing accurate results by producing customer tailored arrays.
The Korea Centers for Disease Control and Prevention has developed arrays optimized for Koreans by studying disease-related genetic factors that appear in Koreans. We provide services for the developed arrays to be utilized for Korean research.
Chip for orean
PMRA consists of 903,000 genetic markers that can identify SNPs and CNVs that are closely relat-ed to diseases, enabling us to conduct precision medical research in an efficient way.
PMRA (Precision Medicine Research Array)
03 Genome-Report: Automated Analysis Report www.genome-report.com
Genome-Report is a system that makes it easy to analyze complicated bioinformation analysis on the web. More than 30 bioinformatics professionals have been building an optimal pipeline through various analysis experiences, and the developed Genome-Report provides efficient and advanced analysis results.
Service Type
Service by array type
Analysis of gene expressionlevel and expression level difference
Describe the various mechanisms and phenomena of living organisms by comparing gene expression level and difference in gene expression level
Analysis that detects gene mutationsGenetic mutation
Somatic mutation
Gene fusion
Protein structure prediction
Identify significant somatic mutation and causative mutation in cancer disease
Identify gene fusion that is a key to cancer genome research
Predict protein structure changes according to RNA sequence
Microarray
Korean SNP Chip
PMRA
OpenArray
HelloGene
GeneStyle
. . .
. . .
It is the time to break away from health care that has been done in the same way for everyone and more towards the neces-sary that is individual custom-ized health care that is differen-tiated according to individual genetic diversity. Finding your own DNA secret will become the best strategy to protect your health and life.
Macular development
Glaucoma
DiabetesHigher than the average
High
Very high
Changes in the medical paradigm, from cure to care
The healthcare service that shows the possibility of developing a specific disease by using a genetic marker as an indicator is recording a high share in the domestic market. Using verified and highly reliable genetic markers, we provide a variety of useful information about various diseases such as cancer, general diseases, food and drug reactions, and physical characteristics.
THERAGEN ETEX_Genomic innovations, Healthcare solutions 12
05 HelloGene : Personal Gene Analysis Service www.hellogene.com/kor/hellogene
HelloGene service is
Intake of Omega-3 fatty acid with preventive effect
Regular intraocular pressure measurement
Diet Control Periodic exercise program
13 THERAGEN ETEX_Genomic innovations, Healthcare solutions
GeneStyle Hair Inspect the genetic characteristics that affect hair loss to identify the risk of hair loss and analyze the optimal scalp hair care method for you.
GeneStyle Direct GeneStyle Direct is a gene test service that helps individuals manage their health and beauty by analyzing the genetic characteristics of individuals based on 41 genetic indicators recognized by the Ministry of Health and Welfare. We are providing health functional food elements recommended by doctors and pharmacists and cosmetic ingredients and management methods recommend-ed by cosmetics experts and differentiated solutions. Currently, it is sold offline in about 200 pharmacies nationwide and online through hellogene.com.
06 GeneStyle : Health & Beauty Management Service www.hellogene.com/kor/genestyle
Hair thicknessHair lossPigmentation Vitamin C concentration
Skin elasticitySkin aging
BMI (Body Mass Index)
Cholesterol Caffeine metabolism
Triglyceride concentration
Blood sugar Blood pressure
GeneStyle Fitness Inspect genetic characteristics that affect body shape management and suggest individual customized body shape management and health management methods.
GeneStyle Inner Health Identify the genetic characteristics that affect the inside of the body and provide optimal healthcare solutions.
GeneStyle Outfit Beauty Care
Identify genetic characteristics that affect appearance and provide optimal beauty care solutions.
THERAGEN ETEX_Genomic innovations, Healthcare solutions 14
Melaphy mist
Melaphy mist is a mist that you can feel the healing effect of a natural forest bath due to the
combination of cypress phytoncide and hydrogen. ou not only have an immediate moisture supply,
but also feel stress relief, skin relaxation, skin whitening, and can use it without irritation due to a
natural surfactant ingredient.
Melaphy mask
Melaphy mask is a highly moisturizing mask pack with unique phytoncide flavor. It is excellent
for sensitive skin care and has a trouble calming effect. It is a mask pack that you can feel skin
radiance just by using it once.
Melaphy Line
GeneStyle Skin GeneStyle Skin is a program that provides individual customized cosmetic solutions combining cosmetic ingredients that match the skin characteristics of an individual by identifying individual genetic information of the skin. As the close relationship between genetic characteristics and aging has been confirmed, interest in individual customized management is increasing. We conduct anti-aging management considering the genetic characteristics of individual through DNA analysis.
Gene Re uvenating Line
Genetic information provided by GeneStyle skin
Rejuvenating skin toner
Fermented filtrate 82 concentrate, which is produced when an alcohol is made in a brewery, supplies moisture to skin, and gives the effect of a natural exfoliator and thus makes your skin transparent and clear.
Gene rejuvenation skin serum
Customized, highly concentrated, functional serum that provides an optimized solution for skin DNA.
Gene rejuvenation skin cream
If you do not want to miss the moisture lost in your skin, you need silk protein. As it contains a large amount of silk protein that moisturizes skin for a long time.
ELASTICIT SUN DAMAGE
WRINKLE
FREE RADICAL DAMAGE
PIGMENTATION
SENSITIVIT INFLANMATION
GENEST LESKIN
15 THERAGEN ETEX_Genomic innovations, Healthcare solutions
08 Subsidiary Company
MedPacto is a specialized company that develops anticancer medicine. TEW-7197, an anticancer drug for oral use, acts on TGF-beta receptor kinase type 1, received IND approval from US FDA, and has demonstrated safety and effectiveness based on the results of several studies.
01 MedPacto Development of new anticancer drugs
www.medpacto.com
02 NIPT (Non-invasive Prenatal Test) Service
GenomeCare is a gene test specialized company for before childbirth and implantation and aims to contribute to the welfare of mankind through safe birth by discovering gene mutation that causes infertility and pregnancy difficulty through NGS technology for women who are pregnant or planning pregnancy.
03 Leadpharm Professional Drug Distribution
www.leadpharm.com
LeadPharm, centered on the pharmacy chain business, supplies pharma-ceuticals to hospitals and pharmacies. It provides the best products that are competitive and differentiated and doing its best to create values by actively supporting member companies. LeadPharm is constantly making efforts with a sense of vocation for the healthy life of mankind.
04 Theragen HealthCare Medical Supplies Manufacturing and Distribution
Theragen Healthcare and Daeil Pharmaceutical have been researching and developing various diabetic products in the era of about 5 million people with diabetes and have been distributing them to pharmacies and health-care shops. In addition, we are developing a variety of products in the healthcare field and advancing to be a responsible company with the goal of improving the quality of human life.
Etex Pharmaceutical, founded in 1990, is a specialized company for manu-facturing first generic and improved drugs. We do stable and highly reliable drug production and quality control through KGMP facility. We produce 200 kinds of drugs and have fast and efficient sales and distribution system through 9 branches nationwide.
07 Etex Pharmaceutical Manufacture and Sale of Medicine www.etexpharm.com
THERAGEN ETEX_Genomic innovations, Healthcare solutions 16
II Research and Resources 01 Research Results
Collaborative Research and Development Projects with Several Excellent Universities and Hospitals
National Research Projects or R&D Projects with Other Companies
- Ongoing collaborative research with many excellent universities and hospitals (R&D)- Lung cancer research in Oncology Internal Medicine of Seoul National University Hospital- Joint research of lung cancer and stomach cancer research with National Cancer Center- Cancer research in Oncology Internal Medicine of Shinchon Severance Hospital- Korean skin marker research with Dermatology of Chungnam National University Hospital and LG Healthcare- Joint research on the analysis of cloned dog genome with Veterinary Science Department of Seoul National University
A study on early diagnosis through the discovery of gastric cancer target gene group unique in Koreans
(Genome Research, July 23, 2013)
Decoding the Minke whale genome for the first time in the world
(Nature Genetics, June 18, 2013)
Release of world's first tiger genome map
(Nature Communication, May 2, 2013)
- Under development of Hellogene Skin with AMOREPACIFIC- Joint research on genome of the bat with School of Veterinary, Seoul National University - Research on the development of breeding with Nongwoo Bio - Agreement on an NIPT project with SCL - -Conducted industrial source technology development project, "Research and Commer-cialization of Genome using Next-generation Bioinformation", of the Ministry of Commerce, Industry and Energy (2011-2016)- Carried out "Decoding the Genome and RNA of the Whale Leading and Analyzing the Bioinformation" task of the Ministry of Maritime Affairs and Fisheries (2011-2013)- Completion of the world's first whale leading genome decoding and publication of research results in the world renowned academic journal (2014.11)- Korean genome analysis project of the Ministry of Health & Welfare, Exome sequencing data production for identifying genetic factors of obesity in adolescents (2013)- Performed post-genome multi-ministry genome project of the Ministry of Food, Agriculture and Forestry and Fisheries and Rural Development Administration (2014-2018) - Conducted a study on detoxification of shiitake mushroom genome with Chungbuk National University- Genome analysis of transgenic cow of veterinary corps of Seoul National University- Participated in genomic information construction project using Korean gene chip
03 Equipment Status
04 Server Resources
THERAGEN ETEX_Genomic innovations, Healthcare solutions 18
uantStudio
Existing decoder held by Theragen
BeadXpress
Ion PGM sequencer Ion Proton sequencer GeneTitan LC480
Fluidigm
MicroarrayNext generation base sequence
HiSeq4000 HiSeq2500Novaseq 6000
Bioinformatics Computer Server
Over CPU 5,000 CoreFast and reliable storage and calculation of data
BioinformaticsStorage Servers
Over 5 PB Storage Rapid and reliable storage and backup of data
Emergency Power Equipment
40KW UPSMinimize server downtime and ensure safety during power failure
Bioinformaticseb servers
Over 350 Servers
19 THERAGEN ETEX_Genomic innovations, Healthcare solutions
05 Appreciation (1) – Government-Approved Best uality
06 Certification Program : Certified Service Provider
Certificate of Gene Inspection AccuracyOnly company in Korea to
receive the highest grade certification for genetic testing accuracy
evaluation for four consecutive years
Technical patent certificateHolds a large number
of patents for managing developed technologies as a result
of research
ISO9001 certificationObtained international certification of accurate quality management system for services
Illumina service provider
Agilent service provider
Affymetrix service provider
Life technologies service provider
The certification program is a quality verification program for a variety of genome analysis platforms, including genome decoding equipment and library kits. Customers can trust our services because consistent service with the best quality can be provided.
07 Ma or History
THERAGEN ETEX_Genomic innovations, Healthcare solutions 20
201612 Analysis automation report service conducted genome-report
09 Launched HelloGene I, a HelloGene derivative product
06 Launch of GeneStyle (health & beauty care service)
05 Selected as a job excellent company in Gyeonggi-do
05 Launch of BRCAinside service, a gene test of breast cancer / ovarian cancer
201705 Introduction of Illumina NovaSeq
03 NGS laboratory certification
02 4 consecutive years of highest grade certification for the genetic testing accuracy evaluation
08 HelloGene, personal genetic information services, sales contract with uhan Corporation
05 Next-generation genome cancer genome analysis platform development(Oncomics)
01 Next-generation genome mass analysis platform development(Xomics)
12 Established a local corporation in China for entering into the Chinese market and for joint ventures
03 03 Concluded partnership with Australian Skin DNA to Enhance skin DNA analysis and personalized consulting services
2009 Leading participation in Pan-Asian Genetic Diversity Study Consortium(Science, 2009)
2008 Participated in Korean Genome Project(Genome Research 2009
11 ISO9001 2008 certification of Bio Research Center( uality management systems)
04 Published "Discovery of Diffuse Gastric Cancer-inducing Mutation Gene" with the National Cancer Center
in Genome Biology
01 HelloGene services started clinical studies with 18 general hospitals
01 Completed the world's first decryption of whale genome and published research results in the journal Nature Genetics
11 Launch of the Asia's first personal genome analysis service, "HelloGene" for the first time in Chinese travelers.
10 The Worlds first Cloned Dog, Snuppy Genome Analysis completion and publication of the research results
in the world journal, Nature
09 The World s first completion of Korean Tiger Genome Project and publication of the research results in the journal,
Nature Communications
06 The Korea s first decoding of Korean Gastric Cancer Gene Mutation and publication of the research results in the
journal, Genome Research
01 Selected as a partner company for industry-university cooperation of Dankook University Sequencing Center
10 Construction of Asian Genome Project(Pan-Asian SNP) Consortium 2.0
09 Completed KT joint project (Full length genome decryption and analysis of 20 Koreans)
08 Selected as a joint research institution for whale genome project of Korea Ocean Research and
Development Institute
07 Selected as an industry source for technological development by the Ministry of Knowledge Economy
12 Launch the Korea s first Korean Personal Genome Project(KPGP)
10 The World s first Tiger Genome Decode and Analysis(Completed in 2011)
05 The World s first Native Soybean Analysis
04 The World s first released Female Genome Decode and Analysis(Rosalynn Gill)
03 Completed "Korean Cow Genetic Map" jointly with Rural Development Administration
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