Highly effective flea control

they’ll both appreciate

Activyl® for CatsActivyl® for DogsActivyl® Tick Plus for Dogs

Burnsville, MN Sun Prairie, WI Des Moines, IA Fort Wayne, IN Valley Forge, PA Owings Mills, MD Dallas, TX1-800-328-2975 1-800-362-9226 1-800-643-9378 1-800-447-7496 1-800-583-8020 1-800-583-8020 1-877-507-6531

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Indoxacarb in Activyl® is metabolized differently in insects vs mammals.1, 2

High toxicity in insects but not in mammals.

Application Activyl® spreads through the natural oils on the pet’s skin.

Bioactivation Enzymes inside the flea change indoxacarb into its highly insecticidal form.

Contact and ingestion

takes up Activyl® (no blood meal necessary).

The flea is unable to feed, becomes paralyzed and dies.

Activyl® is the first flea control product that works through bioactivation.1 How does bioactivation work?

Activyl® breaks the flea life cycle.® is adulticidal, larvicidal and inhibits flea development in the environment.

ACTIVYL® INHIBITED 95%-100% OF FLEA DEVELOPMENT IN THE ENVIRONMENT OF TREATED PETS FOR AT LEAST 35 DAYS POST-TREATMENT.3, 4

95%-100% flea development inhibited for 35 days.

Activyl® is proven highly effective in tests against multiple flea strains in

3

Up to

100% efficacy

in multiple flea strains

Burnsville, MN Sun Prairie, WI Des Moines, IA Fort Wayne, IN Valley Forge, PA Owings Mills, MD Dallas, TX1-800-328-2975 1-800-362-9226 1-800-643-9378 1-800-447-7496 1-800-583-8020 1-800-583-8020 1-877-507-6531

Contact your Midwest Veterinary Supply Representative for more information!

www.midwestvet.net

Activyl® contains indoxacarb, a molecule with an innovative mode of action for flea control.

an innovative mode of action for flea control.

Activyl® is waterproof and remains effective after shampooing.3, 6

Activyl® safety studies.Activyl® demonstrated a good margin of safety when extensively tested in studies in dogs, cats, puppies and kittens.3

Activyl® is approved for use on:

Activyl® effectively controls fleas in the home environment and prevents re-infestation.In field trials in the EU, with 33 veterinary clinics, dogs and cats

®.

Percentage of dogs free of fleas after 3 months (P=0.0042).*

Activyl® Activyl®

Percentage of cats free of fleas after 3 months (P=0.0204).*

UP TO 98.9% FLEA-FREE DOGS AND CATS AFTER 3 MONTHLY TREATMENTS.3, 5

98.9%

87.7%

DOGS CATS

AA

*Statistically significant difference.

Activyl® provides effective initial and persistent protection for a full month.3

Initial Speed of Kill

Kills 90% of fleas on pet within

application.3 Kills90%

Kills newly arriving fleas within

a full month.3

Kills up to 100%

Persistent Speed of Kill

Burnsville, MN Sun Prairie, WI Des Moines, IA Fort Wayne, IN Valley Forge, PA Owings Mills, MD Dallas, TX1-800-328-2975 1-800-362-9226 1-800-643-9378 1-800-447-7496 1-800-583-8020 1-800-583-8020 1-877-507-6531

Contact your Midwest Veterinary Supply Representative for more information!

www.midwestvet.net

If you were a dog, what would you do about ticks and fleas?

Activyl® Tick Plus safety studies.3

Activyl® Tick Plus was extensively tested in safety studies in dogs and puppies at 1x, 3x and 5x the recommended dose.3

No adverse effects even at 5x the recommended dose.5x

recommended dose

for a full month.

from 8 weeks of age.

in the home environment.

and exposure to sunlight.

Activyl® Tick Plus combines indoxacarb for effective flea control with permethrin for proven tick protection in dogs.

for Dogs

ed

Burnsville, MN Sun Prairie, WI Des Moines, IA Fort Wayne, IN Valley Forge, PA Owings Mills, MD Dallas, TX1-800-328-2975 1-800-362-9226 1-800-643-9378 1-800-447-7496 1-800-583-8020 1-800-583-8020 1-877-507-6531

Contact your Midwest Veterinary Supply Representative for more information!

www.midwestvet.net

*American Dog tick (D. variabilis).

Tick efficacy: Kills > 96% of ticks even 30 days after application.3

American Dog Tick (D. variabilis) which may transmit Rocky Mountain spotted fever.6

Brown Dog Tick (R. sanguineus) which may transmit ehrlichiosis, Rocky Mountain spotted fever, and babesiosis.6

Deer Tick (I. scapularis) which may transmit Lyme disease and anaplasmosis.6

Lone Star Tick (A. americanum) which may transmit ehrlichiosis, Rocky Mountain spotted fever, and tularemia.6

New ticks applied on days -2, 7,14, 21, 28 and 35. Tick count 48 hours post tick challenge.

% E

ffic

acy

DAY 2 DAY 9 DAY 16 DAY 23 DAY 30 DAY 37

100

80

60

40

20

0

Tick repellency: 3

Activyl® Tick Plus (n = 10)

DAY 2 DAY 7 DAY 14 DAY 21 DAY 28

100

80

60

40

20

0

87.5%99.0% 93.4% 95.7%

87.5%

Activyl® which may transmit diseases.

Same flea protection as Activyl®, plus:

for Dogs

Burnsville, MN Sun Prairie, WI Des Moines, IA Fort Wayne, IN Valley Forge, PA Owings Mills, MD Dallas, TX1-800-328-2975 1-800-362-9226 1-800-643-9378 1-800-447-7496 1-800-583-8020 1-800-583-8020 1-877-507-6531

Contact your Midwest Veterinary Supply Representative for more information!

www.midwestvet.net

ACTIVYL® IS MADE IN THE U.S.A.

Copyright © 2012 Intervet Inc., a subsidiary of Merck & Co., Inc. All rights reserved. Intervet Inc. d/b/a Merck Animal Health, Summit, NJ, 07901 MAH-ACT-70Merck Animal Health Track & Trace is a trademark of Intervet Inc.

Merck Animal Health and Activyl® Tick Plus provide more service to support your clients, your patients and your business:

Activyl® Tick Plus is EPA approved.

New formulation and packaging for improved compliance:

Single month presentations – Allow for exact dosing of growing puppies

– Provide flexible dispensing options

Six month presentations – Ensure long-term parasite control

Easy-to-use snap-open applicator: Opens easily without scissors, leaving the other hand free to hold the pet.

See-through applicator facilitates administration

Track & Trace Technology

Allows identification of single month and six month packs using unique ‘FINGERPRINT’ barcodes.

Tracks Activyl® through all touchpoints in the distribution chain.

Helps identify diverters, facilitates anti-diversion enforcement.

Why Track & Trace is important

wellbeing of pets.

can provide the highest standard of care.

professional hands to ensure optimum results.

Merck Animal Health Track & Trace™ System. Developed to protect your patients and your business.

For further information:us.activyl.com

Staff Program Satisfaction Guarantee Merck Animal Health Track & TraceTM

Puppy and Kitten Kits Merchandising Material Consumer Marketing

for DogsActivyl® for CatsActivyl® for DogsActAct

1. Wing KD, Sacher M, Kagaya Y, Tsurubuchi Y, Mulderig L, Connair M, Schnee M. Crop Protection. 2000;19:537-545.2. Wing KD, Andaloro JT, McCann SF, Salgado VL. Indoxacarb and the sodium channel blockers: chemistry, physiology and biology in insects.

In: Gilbert LI, Iatrou K, Gill SS, eds. Comprehensive Molecular Insect Science. New York: Elsevier. 2005;31-53.3. Data on file, Merck Animal Health.4. Guerino F, Qureshi T, Hair J, Young D, Fourie J. Indoxacarb kills developing stages of fleas in the environment of treated cats.

Presented at the BSAVA / WSAVA / FECAVA World Congress, 11-15 April 2012, Birmingham, UK.5. Flochlay-Sigognault A, Regis F, Sun F, Guerino F. Field efficacy of a spot-on formulation of indoxacarb for flea control in dogs and cats. Poster presented at:

23rd International Congress of the World Association for the Advancement of Veterinary Parasitology (WAAVP), 21-25 August 2011, Buenos Aires, Argentina. 6. Bowman DD, ed. Georgis’ Parasitology for Veterinarians, 9th ed. St. Louis: Saunders Elsevier. 2009.

Burnsville, MN Sun Prairie, WI Des Moines, IA Fort Wayne, IN Valley Forge, PA Owings Mills, MD Dallas, TX1-800-328-2975 1-800-362-9226 1-800-643-9378 1-800-447-7496 1-800-583-8020 1-800-583-8020 1-877-507-6531

Contact your Midwest Veterinary Supply Representative for more information!

www.midwestvet.net