Hemodynamic Disorders, Thromboembolic Disease and Shock ...
Transcript of Hemodynamic Disorders, Thromboembolic Disease and Shock ...
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2nd Department of Pathology
Lilla Madaras
Hemodynamic Disorders, Thromboembolic Disease
and Shock (Part 2)
15th September 2021
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Hemodynamic disorders
• Hyperemia (active and passive)
• Edema
• Hemorrhage
• Thrombosis
• Embolism
• Infarction
• Shock
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INFARCTION
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ISCHEMIA
• Definition: Decreased perfusion of organs and tissues
• Causes: arterial obstruction,– (relative ischemia)
• Transient ischemia (eg: coronary arteries –angina pectoris, cerebral arteries- TIA)
• Long standing ischaemia: reversible –irreversible injury
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INFARCTION• Ischemic necrosis due to impaired
arterial supply or venous drainage
• In 99% due to thrombosis or embolism (mainly arterial occlusion)
• Other mechanisms: vasospasm, hemorrhage to atherosclerotic plaque, vascular compression (e.g. by a tumor), torsion (testis, ovary)
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SUBTYPES OF INFARCTION 1.
ANEMIC (white) INFARCTS
• Coagulative necrosis
• Arterial (end arteries) occlusion
• In solid parenchymal organs
• Heart, spleen, kidney
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Renal infarction
Splenic infarction
AMI
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Renal infarction (+?)
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Anemic infarction- kidney
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SUBTYPES OF INFARCTION 2.HEMORRHAGIC (red) INFARCTS
1. Obstruction to venous outflow
2. In loose tissues
3. In organs with a dual circulation(eg. lung, bowel)
4. If preceeded by congestion
5. When blood flow is re-established
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12Hemorrhagic infarct-lung
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13Hemorrhagic infarcts
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Hemorrhagic infarction-testis
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SPECIAL ORGANS 1.LIVER
HEPATIC ARTERY thrombosis, embolism-(eg. vasculitis, sepsis)
1. No infarction
2. Anemic infarction
3. Hemorrhagic infarction
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SPECIAL ORGANSLIVER cont.
PORTAL VEIN THROMBOSIS (pylethrombosis)Intrahepatic – no infarction, only marked
congestion (Zahn infarction- misnomer!)
Extrahepatic – severe- abdominal pain, ascites, portal hypertension, bowelinfarction
HEPATIC VEIN THROMBOSIS
Budd-Chiari syndrome
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Zahn infarctionAnemic infarction
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SPECIAL ORGANSBRAIN
Liquefactive necrosis
Emmolitio (encephalomalacia) alba- anemic
Emmolitio (encephalomalacia) rubra-hemorrhagic
Cysta ex emollitione- cyst
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SHOCK
• Definition: clinical symptoms due decreased cardiacoutputresulting in systemic hypoperfusion, cellularhypoxia
• Clinical signs: Blood pressure↓, tachycardia, tachypnoe, skin cold and cyanotic (or flushed and warm)
• Forms:– Hypovolemic– Cardiogenic– Shock associated with systemic inflammation
(Septic/Endotoxic)– Neurogenic– Anaphylactic– Endocrine– Traumatic
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Major forms of shock
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Robbins, 8th edition
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Events in shock
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Stages of shock
• Nonprogressive phase- blood supply of vital organs still maintained (neurohumoral reflexes!)
• Progressive phase- increasing circulatory and metabolic disturbance (acidosis!)
• Irreversible phase - tissue damage so severe that survival is not possible
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Manifestations of shock (results of hypoxia)• Kidney
– Macr: cortex pale and widened, medulla cyanotic– Micr: arteriole constriction, fibrin thrombi, tubular epithelial damage (acute tubular
necrosis)• Lung
– Macr: livid, firm– Micr: ARDS (diffuse alveolar damage) in septic shock
• Liver– Microthrombi, centrilobular necrosis
• GI tract– Erosions, acute ulceration, hemorrhage
• Brain– Purpurae, hemorrhage, cortical necrosis (pseudolaminar necrosis), watershed necrosis
• Heart– Coag. necrosis, subendocardial hemorrhage
• Endocrine organs– Hemorrhage and necrosis (Sheehan sy, Waterhouse- Friderichsen sy), cortical cell
lipid depletion in the adrenals, fibrin thrombi in DIC
→ MULTIORGAN FAILURE
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25Shock- kidneys
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DIC- adrenal cortex
Brain- pseudolaminar necrosis
ARDS