Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem...

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Hematopoiesis the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood cells Cells/Organs of the Immune System

Transcript of Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem...

Page 1: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Hematopoiesis – the formation and development of red and white blood cells.

Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood cells arise.

Cells/Organs of the Immune System

Page 2: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Cells of the Immune SystemLeukocytes – White blood cells

Myelocytes –macrophage, neutrophil, eosinophil,basophil

Leukocytes – B, T and NK cells

From Larsson and Karlsson (2005)

Page 3: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.
Page 4: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Cells of the Immune System

Larsson and Karlsson (2005)

Page 5: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Homeostasis - The ability or tendency of an organism or cell to maintain internal equilibrium by adjusting its physiological processes.

Cells of the Immune System

Page 6: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Cells of the Immune SystemExamples of apoptosis

LM

SEM

Page 7: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Myeloid cells

Dendritic cell

Page 8: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Mononuclear phagocytes–Endocytosis takes material into a cell within vesicles that bud inward from the plasma membrane.

Page 9: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Mononuclear phagocytes

Page 10: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Granulocytic cellsNeutrophil

Page 11: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Lymphocytes:

T cellsB cells Natural killer cells

Cells of the Immune System

Page 12: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Lymphocyte fate following antigen activation:

Cells of the Immune System

Page 13: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Recall:Jerne, Talmadge & Burnet – clonal selection theory

Page 14: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

B lymphocytes (B cells)

Page 15: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

T lymphocytes (T cells)

T reg cell

Page 16: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

•Natural killer cells – distinct from T and B cells due to lack of an antigen binding receptor, similar in function to TC cells.

NK Cells

Page 17: Hematopoiesis – the formation and development of red and white blood cells. Hematopoietic stem cells (HSC) – the cell type from which all lineages of blood.

Dendritic cells