Heat Shock Protein 47 (HSP47) Pathway...Heat Shock Protein 47 (HSP47) Pathway HSP47 and Fibrosis •...
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HSP47 and the collagen synthesis pathway are one of many pathways under investigation at Bristol-Myers Squibb. Learn more about our work in fibrosis by visiting: www.bms.com/researchers-and-partners/areas-of-focus.html About HSP47 Heat shock protein 47 (HSP47) is a molecular chaperone involved in the formation and stabilization of collagen molecules. Collagen is a structural protein that is found in skin and other connective tissues throughout the body. HSP47 guides the correct folding of the collagen protein and ensures it maintains the correct structure. 1,2 1 Widmer C, Gebauer JM, Brunstein E, et al. Molecular basis for the action of the collagen-specific chaperone HSP47/SERPINH1 and its structure-specific client recognition. PNAS 2012;109(33):13243-13247. 2 Taguchi T, Nazneen A, Al-Shihri AA, et al. Heat shock protein 47: a novel biomarker of phenotypically altered collagen-producing cells. Acta Histochem Cytochem. 2011;44(2):35-41. Heat Shock Protein 47 (HSP47) Pathway HSP47 and Fibrosis • Fibrosis is a stage of scarring characterized by the accumulation of the protein collagen. • Increased levels of HSP47 contribute to the production and accumulation of excessive amounts of collagen, which promotes the formation of fibrosis. 2 • Elevated levels of HSP47 are observed in models of fibrosis and human fibrotic disease. 1,2 Research Implications • Targeted downregulation of HSP47 in the liver can lead to improper folding of collagen within cells. • Without proper folding, collagen clumps together inside of cells, decreasing the amount of collagen that is secreted outside of the cell. • A decrease in the amount of secreted collagen may lead to a decrease in fibrosis. Collagen-Synthesizing Cell Collagen Helix HSP47 HSP47 resides in the endoplasmic reticulum (ER) of collagen-synthesizing cells. 1 Elastin Collagen HSP47 Collagen production Fibrosis Elastin Reduced Collagen HSP47 Collagen production Fibrosis
Transcript of Heat Shock Protein 47 (HSP47) Pathway...Heat Shock Protein 47 (HSP47) Pathway HSP47 and Fibrosis •...
HSP47 and the collagen synthesis pathway are one of many pathways under investigation at Bristol-Myers Squibb. Learn more about our work in fibrosis by visiting: www.bms.com/researchers-and-partners/areas-of-focus.html
About HSP47Heat shock protein 47 (HSP47) is a molecular chaperone involved in the formation and stabilization of collagen molecules. Collagen is a structural protein that is found in skin and other connective tissues throughout the body. HSP47 guides the correct folding of the collagen protein and ensures it maintains the correct structure. 1,2
1 Widmer C, Gebauer JM, Brunstein E, et al. Molecular basis for the action of the collagen-specific chaperone HSP47/SERPINH1 and its structure-specific client recognition. PNAS 2012;109(33):13243-13247. 2 Taguchi T, Nazneen A, Al-Shihri AA, et al. Heat shock protein 47: a novel biomarker of phenotypically altered collagen-producing cells. Acta Histochem Cytochem. 2011;44(2):35-41.
Heat Shock Protein 47 (HSP47) Pathway
HSP47 and Fibrosis
• Fibrosis is a stage of scarring characterized by the accumulation of the protein collagen.
• Increased levels of HSP47 contribute to the production and accumulation of excessive amounts of collagen, which promotes the formation of fibrosis.2
• Elevated levels of HSP47 are observed in models of fibrosis and human fibrotic disease.1,2
Research Implications
• Targeted downregulation of HSP47 in the liver can lead to improper folding of collagen within cells.
• Without proper folding, collagen clumps together inside of cells, decreasing the amount of collagen that is secreted outside of the cell.
• A decrease in the amount of secreted collagen may lead to a decrease in fibrosis.
Collagen-Synthesizing Cell
Collagen Helix
HSP47
HSP47 resides in the endoplasmic reticulum (ER) of collagen-synthesizing cells.1
Elastin
CollagenHSP47
Collagen production
Fibrosis
Elastin
Reduced CollagenHSP47
Collagen production
Fibrosis
