TUESDAY, APRIL 30, 2019

Hearty NewsQuarterly Cardiovascular Medicine Newsletter

Spring 2019

Appointments and Promotions

Faculty

Promotions

New appointments

Reappointments

Mohan Viswanathan MD was promoted to Clinical Professor (CardiovascularMedicine) on April 1, 2019. Congratulations Mohan!

Colleen Caleshu ScM LCGC was appointed to Clinical Associate Professor(Cardiovascular Medicine and by courtesy, Medical Genetics) on February 10, 2019. Colleen trained at Johns Hopkins and the National Human Genome Research Institute. She leads the genetic counseling team in the Stanford Center for Inherited Cardiovascular Disease. Her research focuses on genetic counseling and inheritedcardiovascular disease.

Rahul Sharma MD was appointed to Clinical Assistant Professor (CardiovascularMedicine) on March 11, 2019. Rahul trained in Melbourne, Australia and then did an advanced interventional/structural fellowship at Cedars-Sinai, before joining their faculty. He will be starting as a Clinical Assistant Professor and Director of Structural Interventions with a goal of further expanding our transcatheter heart valve and structural programs.

Peter Fitzgerald MD PhD was reappointed to Emeritus Professor (CardiovascularMedicine) on March 1, 2019.

Victor Froelicher MD was reappointed to Emeritus Professor (CardiovascularMedicine) on March 1, 2019.

Federal Grants and Subcontracts

Kiran Khush – National Institutes of Health subcontract with Massachusetts General Hospital “Targeting inflammation and alloimmunity in heart transplant recipients with Tocilizumab” May 1, 2018 – April 30, 2021

Patricia Nguyen – National Institutes of Health R03 grant “The contribution of T cells to the pathogenesis of atherosclerosis in older adults” August 1, 2018 – July 31, 2020

Euan Ashley and Matthew Wheeler – National Institutes of Health U01 grant “Center for Undiagnosed Diseases at Stanford” Phase II

Adjunct Faculty

Staff

New appointments

Uma Valeti MD was appointed to Adjunct Professor (Cardiovascular Medicine) onMarch 1, 2019.

Sujana Balla, Clinical Research Coordinator Associate, is working with Dr. KoenNieman and the Electrophysiology group on various clinical trials. Sujana started on February 11th.

Andrea Linder, Research Nurse, is working with Dr. Matthew Wheeler on variousclinical trials. Andrea started on February 25th.

Justin Toralba, Administrative Associate 2, is suppporting the Interventional group. Justin started on March 11th.

Alyssa Sacro will be taking on a new role in the Division as Clinical Trials Accounting Associate starting on April 1, 2019.Congratulations to Alyssa!

Grants and Awards

September 21, 2018 – June 30, 2022 September 21, 2018 – June 30, 2022

Non-federal Grants and Contracts

Announcing the Translational Investigator Program (TIP) matches for 2020!

Thomas Quertermous – National Institutes for Health R01 grant “lncRNA transcriptional mechanisms of coronary artery disease risk” January 18, 2019 – December 31, 2022

William Fearon – National Institutes of Health R61 grant “PCSK9 inhibition after heart transplantation” February 1, 2019 – January 31, 2020

Fatima Rodriguez – National Institutes of Health K01 grant “SURPASS: (Statin Use and Risk Prediction of Atherosclerotic Cardiovascular Disease in minoritySubgroups)” February 1, 2019 – January 31, 2024

Alan Yeung – TriReme Medical Inc. contract“Assessment of inproved interventional devices for cardiovascular disease – catheter evaluation” September 1, 2018 – August 31, 2020

Joshua Knowles – United States-Israel Binational Science Foundation (BSF) grant “An effort to flag and identify FH patients in Clalit Health Services using machine learning algorithms”

October 1, 2018 – October 1, 2022

Victoria Parikh – Sarnoff Cardiovascular Research Foundation grant “Regional variants in RBM20 cause arrhythmogenic cardiomyopathy” October 15, 2018 – October 14, 2020

Kiran Khush – CareDX, Inc. contract“SURVEILLANCE HEALTHCARE OUTCOMES SURVEY (SHORE)”December 14, 2018 – January 6, 2024

Chad Brodt – Boston Scientific Corporation contract “PREcision Event Monitoring of PatienTs using HeartLogic” March 8, 2019 – March 7, 2021

Kiran Khush – 2019 ISHLT/Enduring Hearts Transplant Longevity Research grant “Leukotriene B4: A potential mediator and biomarker for cardiac allograft vasculopathy” May 1, 2019 – April 30, 2021

Cardiology Fellowship Program

Daniel Kim (Stanford) Stephen Ma (Stanford)

Featured Fellows at American College of Cardiology

Congratulations to David Ouyang for receiving an American College of CardiologyFoundation/Merck Research Fellowship in Cardiovascular Medicine award for his project “Data Science and Machine Learning for Cardiovascular Imaging”.

Publications

Cost-effectiveness of Canakinumab for Prevention of Recurrent Cardiovascular Events.Sehested TSG, Bjerre J, Ku S, Chang A, Jahansouz A, Owens DK, Hlatky MA, Goldhaber-Fiebert JD. JAMA Cardiol. 2019 Feb 1;4(2):128-135. doi: 10.1001/jamacardio.2018.4566.

Interventions to Reduce Ethnic and Racial Disparities in Dyslipidemia Management. Chang A, Abou-Arraj N, Rodriguez F. Current Treatment Options in Cardiovascular Medicine, 2019. [Preprint]

Association Between Female Corresponding Authors and Female Co-Authors in Top Contemporary Cardiovascular Medicine Journals.Ouyang D, Harrington RA, Rodriguez F. Circulation. 2019 Feb 19;139(8):1127-1129. doi: 10.1161/CIRCULATIONAHA.118.037763.

Practice Variation in Anticoagulation Prescription and Outcomes after Device-Detected Atrial Fibrillation: Insights from the Veterans Health Administration.Perino AC, Fan J, Askari M, Heidenreich PA, Keung E, Raitt MH, Piccini JP, Ziegler PD, Turakhia MP.Circulation. 2019 Mar 17. doi: 10.1161/CIRCULATIONAHA.118.038988.

Secular trends in success rate of catheter ablation for atrial fibrillation: The SMASH-AF cohort.Perino AC, Leef GC, Cluckey A, Yunus FN, Askari M, Heidenreich PA, Narayan SM, Wang PJ, Turakhia MP. Am Heart J. 2019 Feb;208:110-119. doi: 10.1016/j.ahj.2018.10.006.

Efficacy of Ablation Lesion Sets in Addition to Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation: Findings From the SMASH - AF Meta-Analysis Study Cohort.Cluckey A, Perino AC, Yunus FN, Leef GC, Askari M, Heidenreich PA, Narayan SM, Wang PJ, Turakhia MP. J Am Heart Assoc. 2019 Jan 8;8(1):e009976. doi: 10.1161/JAHA.118.009976.

Connor O'BrienModerated poster presentation entitled: Microvesicles Larger than 200nm Rescue Cardiomyocytes from Doxorubicin Injury in a Patient-Specific Model of Anthracycline Induced Cardiomyopathy Session: Heart Failure and Cardiomyopathies: Cutting Edge Basic Science Reports

David OuyangOral presentation entitled: Big Data Analysis and Machine Learning in Cardiovascular Imaging Session: ACC Research Awards

Justin ParizoPoster presentation entitled: Evaluation of Trends in Readmission and Mortality Rates after Heart

Failure Hospitalization in the Veterans Affairs Health Care System Between 2007 and 2017 Session: Heart Failure and Cardiomyopathies: Clinical 1

Alex PerinoOral Presentation entitled: How Much Atrial Fibrillation is Too Much? Treatment Benefit of Anticoagulation Based on Threshold of Device-Detected AF Session: Highlighted original research: Arrhythmias and Clinical EP and the year in review

Albert RogersModerated poster presentation entitled: Machine Learning Identifies Sites Where Ablation Terminates Persistent Atrial FibrillationSession: Atrial arrhythmias: What the latest research tells us about mechanism and outcomes

Poster presentation entitled: Intraclass Correlations of Voltage, Fractionated Electrograms, andDominant Frequency in Patients Where Localized Ablation Terminated Persistent Atrial Fibrillation Session: Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias 5

Pablo Sanchez (2019-2020 Fellowship class)Poster presentation entitled: Contributors to Respiratory Failure and Outcomes in the Cardiac Intensive Care Unit Session: Acute and Stable Ischemic Heart Disease: Clinical 4

Alberta YenPoster presentation entitled: Innovative Ultrasound Technologies EchoGPS and AutoEF Help Novices Perform Efficient and Accurate Echocardiographic Monitoring in Cancer PatientsSession: Non-invasive imaging: Echo

Our Team in the News

Drug reduces risk of kidney failure in people with diabetes, study findsDr. Kenneth Mahaffey discusses a drug thatreduces rick in kidney failure in people withdiabetes.

AI identifies risk of cholesterol-raising genetic diseaseDr. Joshua Knowles helped develop analgorithm that can predict a patient’s risk ofpotentially fatal heart disease known ashypercholesterolemia.

Apple Heart Study demonstrates ability of wearable technology to detect atrial fibrillationDrs. Marco Perez and Mintu Turakhia presentedpreliminary data at the American College of Cardiology meeting in March. More than 400,000 participants are enrolled in the Apple Heart Study.

Drug could alleviate side effects of chemo for breast cancer patientsDr. Joseph Wu and collaborators created heartcells known as cardiomyocytes and tested how the cells responded to the effects of the well-known chemotherapy drug Herceptin.

Congenital heart defects vastly increase risk of heart problemslater in lifeDr. James Priest and collaborators found thatpeople born with a minor heart defect are at greater risk of developing heart problems as they get older.

Why are so few interventional cardiologists women? A new study offers a few cluesDr. James Priest and collaborators found thatpeople born with a minor heart defect are at greater risk of developing heart problems as they get older.

Failure to take statins leads to higher mortalityDrs. Fatima Rodriguez and Paul Heidenreichdiscuss the implications for patients that do not take their statins as prescribed.

At event, experts talk heart health and share the latest on Apple Heart StudyDr. Bob Harrington, Chair, Department of Medicine, Stanford University as well as the President of the American Heart Association on a panel at the Apple store for a special event, Heart Health with Apple

CV Med Quarterly Socials –All socials begin at 4:30pm in the Falk Library (or outside patio when weather permits). 2019 Socials are on Thursdays. The next quarterly social will take place in May. Date TBD.

Featured Cardiovascular Medicine Conferences

Cardiology Grand Rounds calendar

Weekly CGR’s are on Thursdays at 8am in the Falk Library.

Stanford Drug Discovery SymposiumApril 22-23, 2019Li Ka Shing Center, StanfordOrganizers: Joseph Wu MD PhD and Mark Mercola PhD

12th Annual Cardiology for the Primary Care PractitionerMay 11, 2019Li Ka Shing Center, StanfordCourse Director: David Lee MD

Big Data in Precision Health ConferenceMay 22-23, 2019Li Ka Shing Center, Stanford

EP in the West – Save the DateSeptember 13, 2019Li Ka Shing Center, StanfordCourse Director: Paul Wang MD

Additional Cardiovascular Medicine CME information

Complete list of Stanford CME courses

Register TODAY!Sunday, September 8, 2019

7:30am – 11:30am

Upcoming Events and Conferences

Monthly:

2018 Frontiers in Cardiovascular ScienceTuesdays from 12:30 – 1:20pmStanford University Li Ka Shing Center2018 Frontiers in Cardiovascular Science

If you are thinking about applying to a grant, email Crystal or Pete to learn more about the Division of Cardiovascular Medicine’s research development and proposal writing resources.

AHA grants

Additional Funding:Cardiovascular Disease Funding Opportunities, Internal Funding Opportunities, Postdocs andClinical Fellows, Graduate Student

RMG Funding Information Resource webpage

NIH, AHRQ and NIOSH K Career Development Award Funding Opportunities and ComputerLab Training Sessions:RMG Index of NIH K award program announcements and other resources

Continuous Submissions

Intermountain-Stanford Collaboration GrantRequest for Letters of Intent for Travel GrantsLetters of intent may be submitted at any time. Applicants will be notified within 21 days ofsubmission.Award Amount: Reimburse actual costsIntermountain-Stanford

Cardiovascular Medicine Training Grants

Cardiovascular Imaging Postdoctoral Fellowship Training at StanfordCV Imaging

Training in Myocardial Biology at Stanford (TIMBS)TIMBS

Mechanisms and Innovations in Cardiovascular Disease T32 Training GrantDeadline: May 1, 2019Start date: July 1, 2019T32

May 2019

Upcoming Funding Opportunities

Stanford Spectrum2019 Spectrum MedTech Pilot GrantsTypical grants range between $15,000 and $50,000 per yearDeadline: May 1, 20192019 Spectrum MedTech

Children's Heart Foundation - Medical Research GrantUp to $100K/yr for 2 yearsSupports clinical and basic science research in congenital heart disease-including but notlimited to these areas: molecular genetics, biochemistry, pharmacology devices, andprocedural research (cardiac catherization and surgery) and long-term care of adults withcongenital birth defects. Eligibility: faculty with PI eligibility and CE faculty (with an approvedCE faculty PI waiver)June 7, 2019https://www.childrensheartfoundation.org/for-researchers/

June 2019

Children's Cardiomyopathy FoundationResearch Grant ProgramAmount of funding: up to $50,000 for one year of total direct costs.Letter of intent (required) deadline: JuneFull proposals (by invitation only) deadline: Sept.CCF

NIH R01 Research Project GrantImproving Patient Adherence to Treatment and Prevention Regimens to Promote Health (R01Clinical Trial Optional)Deadline: June 5, 2019PA-18-722

NIH R01 Research Project GrantImplementation of shared decision making for HLBS diseases and conditions (R01 ClinicalTrial Optional)Deadline: June 5, 2019PA-19-166

NIH Research Project Grant (Parent R01-Clinical Trial Not Allowed)Eligibility: faculty with PI eligibility and CE faculty (with an approved CE faculty PI waiver)June 5, 2019 (Standard R01 deadlines)PA-19-056

NIH Research Project Grant (Parent R01 Clinical Trial Required)*NHLBI only accepts mechanistic studiesEligibility: faculty with PI eligibility and CE faculty with an approved CE faculty PI waiverJune 5, 2019 (Standard R01 deadlines)PA-19-055

Children's Heart FoundationMedical Research GrantUp to $100K/yr for 2 yearsFull application: June 7, 2019

CHF

NIH Mentored Clinical Scientist Research Career Development Award (Parent K08Independent Clinical Trial Not Allowed)June 12, 2019 (Standard K deadlines)PA-19-117

NIH Mentored Clinical Scientist Research Career Development Award (Parent K08Independent Clinical Trial Required)June 12, 2019 (Standard K deadlines)PA-19-116

NIH Mentored Patient-Oriented Research Career Development Award (Parent K23Independent Clinical Trial Required)June 12, 2019 (Standard K deadlines)PA-19-118

NIH Mentored Patient-Oriented Research Career Development Award (Parent K23 –Independent Clinical Trial Not Allowed)June 12, 2019 (Standard K deadlines)PA-19-119

NIH/NHLBI - Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical TrialRequired)June 13, 2019PAR-18-406

July 2019

Dr. Jeffrey Thomas Stroke Shield FoundationBlood Pressure Management Program: Community-research partnerships to reduce strokerate and hypertension in underserved communities in Alameda County, CA New $210,000funding opportunity from a local foundation for Stanford faculty with PI eligibility and CEfacultyLetter of intent (required) deadline: JulyFull proposal (by invitation only) deadline: Sept.GuidelinesLOI instructions

AHAImproving Outcomes in Cancer Treatment-Related Cardiotoxicity (R21 Clinical Trial Optional)LOI (required): July 11, 20192019 Merit Award

NIH R21 Exploratory/Developmental Research GrantMerit AwardDeadline: July 16, 2019PA-19-111

NIH/NHLBI R34 Planning GrantClinical Trial Pilot Studies (R34 Clinical Trial Optional)Deadline: July 16, 2019PAR-19-155

Included in this newsletter are cardiovascular medicine faculty publications for the months of January – April. Publications are in date order from newest to oldest.

APRIL

Cardiac function response to stenting in atherosclerotic renal artery disease with and without heart failure: results from the Carmel study.Kawarada O, Kume T, Zen K, Nakamura S, Hozawa K, Akimitsu T, Asano H, Ando H, Yamamoto Y,Yamashita T, Shinozaki N, Odashiro K, Sato T, Yuba K, Sakanoue Y, Uzu T, Okada K, Fitzgerald PJ, Honda Y, Yasuda S. ESC Heart Fail. 2019 Apr;6(2):319-327. doi: 10.1002/ehf2.12391.

Personalized medicine in cardio-oncology: the role of induced pluripotent stem cell.Sayed N, Ameen M, Wu JC.Cardiovasc Res. 2019 Apr 15;115(5):949-959. doi: 10.1093/cvr/cvz024.

Myocardial viability of the peri-infarct region measured by T1 mapping post manganese-enhanced MRI correlates with LV dysfunction.Tada Y, Heidary S, Tachibana A, Zaman J, Neofytou E, Dash R,Wu JC, Yang PC.Int J Cardiol. 2019 Apr 15;281:8-14. doi: 10.1016/j.ijcard.2019.01.101.

Finding missed cases of familial hypercholesterolemia in health systems using machine learning.Juan M. Banda, Ashish Sarraju, Fahim Abbasi, Justin Parizo, Mitchel Pariani, Hannah Ison, Elinor Briskin, Hannah Wand, Sebastien Dubois, Kenneth Jung, Seth A. Myers, Daniel J. Rader, Joseph B. Leader, Michael F. Murray, Kelly D. Myers, Katherine Wilemon, Nigam H. Shah and Joshua W.Knowles.Npj Digital Medicine. 2019 Apr 11. doi: 10.1038/s41746-019-0101-5.

Single-Cell RNA Sequencing of Human Embryonic Stem Cell Differentiation Delineates Adverse Effects of Nicotine on Embryonic Development.Guo H, Tian L, Zhang JZ, Kitani T, Paik DT, Lee WH, Wu JC.Stem Cell Reports. 2019 Apr 9;12(4):772-786. doi: 10.1016/j.stemcr.2019.01.022.

New CENTERA Transcatheter Aortic Valve: Best of the Balloon-Expandable and Self-Expanding Valve Worlds?Yeung ACJACC Cardiovasc Interv. 2019 Apr 8;12(7):681-683. doi: 10.1016/j.jcin.2019.02.024.

Developing a genomics rotation: Practical training around variant interpretation for genetic counseling students.Grove ME, White S, Fisk DG, Rego S, Dagan-Rosenfeld O, Kohler JN, Reuter CM, Bonner D; Undiagnosed Diseases Network, Ashley EA, Wheeler MT, Bernstein JA, Ormond KE, Hanson-Kahn AK. J Genet Couns. 2019 Apr;28(2):466-476. doi: 10.1002/jgc4.1094.

A toolkit for genetics providers in follow-up of patients with non-diagnostic exome sequencing.Zastrow DB, Kohler JN, Bonner D, Reuter CM, Fernandez L, Grove ME, Fisk DG; Undiagnosed Diseases Network, Yang Y, Eng CM, Ward PA, Bick D, Worthey EA, Fisher PG, Ashley EAM, Bernstein JA, Wheeler MT 3rd. J Genet Couns. 2019 Apr;28(2):213-228. doi: 10.1002/jgc4.1119.

Publications

Years of Potential Life Lost Because of Cardiovascular Disease in Asian-American Subgroups, 2003-2012.Iyer DG, Shah NS, Hastings KG, Hu J, Rodriguez F, Boothroyd DB, Krishnan AV, Falasinnu T, Palaniappan L.J Am Heart Assoc. 2019 Apr 2;8(7):e010744. doi: 10.1161/JAHA.118.010744.

An orange calcium-modulated bioluminescent indicator for non-invasive activity imaging.Oh Y, Park Y, Cho JH, Wu H, Paulk NK, Liu LX, Kim N, Kay MA, Wu JC, Lin MZ. Nat Chem Biol. 2019 Apr 1. doi: 10.1038/s41589-019-0256-z.

MARCH

Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.Kahn-Kirby AH, Amagata A, Maeder CI, Mei JJ, Sideris S, Kosaka Y, Hinman A, Malone SA, Bruegger JJ, Wang L, Kim V, Shrader WD, Hoff KG, Latham JC, Ashley EA, Wheeler MT, Bertini E, Carrozzo R, Martinelli D, Dionisi-Vici C, Chapman KA, Enns GM, Gahl W, Wolfe L, Saneto RP, Johnson SC, Trimmer JK, Klein MB, Holst CR. PLoS One. 2019 Mar 28;14(3):e0214250. doi: 10.1371/journal.pone.0214250

Extracutaneous manifestations in phacomatosis cesioflammea and cesiomarmorata: Case series and literature review.Kumar A, Zastrow DB, Kravets EJ, Beleford D, Ruzhnikov MRZ, Grove ME, Dries AM, Kohler JN, Waggott DM, Yang Y, Huang Y; Undiagnosed Diseases Network, Mackenzie KM, Eng CM, FisherPG, Ashley EA, Teng JM, Stevenson DA, Shieh JT, Wheeler MT, Bernstein JA. Am J Med Genet A. 2019 Mar 28. doi: 10.1002/ajmg.a.61134.

Prometheus Unbound in Ya(p) Heart.Buikema JW, Wu SM.Dev Cell. 2019 Mar 25;48(6):741-742. doi: 10.1016/j.devcel.2019.03.007.

A Patient with Sjogren's Syndrome and Subsequent Diagnosis of Inclusion Body Myositis and Light-Chain Amyloidosis.Hom J, Marwaha S, Postolova A, Kittle J, Vasquez R, Davidson J, Kohler J, Dries A, Fernandez-Betancourt L, Majcherska M, Dearlove J, Raghavan S, Vogel H, Bernstein JA, Fisher P, Ashley E, Sampson J, Wheeler M; Undiagnosed Diseases Network. J Gen Intern Med. 2019 Mar 18. doi: 10.1007/s11606-019-04931-w.

Comparing phase and electrographic flow mapping for persistent atrial fibrillation.Swerdlow M, Tamboli M, Alhusseini MI, Moosvi N, Rogers AJ, Leef G, Wang PJ, Rillig A, Brachmann J, Sauer WH, Ruppersberg P, Narayan SM, Baykaner T.Pacing Clin Electrophysiol. 2019 Mar 18. doi: 10.1111/pace.13649.

Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension.Sweatt AJ, Hedlin HK, Balasubramanian V, Hsi A, Blum LK, Robinson WH, Haddad F, Hickey PM, Condliffe R, Lawrie A, Nicolls MR, Rabinovitch M, Khatri P, Zamanian RT. Circ Res. 2019 Mar 15;124(6):904-919. doi: 10.1161/CIRCRESAHA.118.313911.

Human Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Breast Cancer Patients.Kitani T, Ong SG, Lam CK, Rhee JW, Zhang JZ, Oikonomopoulos A, Ma N, Tian L, Lee J, Telli ML, Witteles RM, Sharma A, Sayed N, Wu JC.

Circulation. 2019 Mar 14. doi: 10.1161/CIRCULATIONAHA.118.037357.

Comparison of QT Interval Measurement Methods and Correction Formulas in Atrial Fibrillation.Tooley J, Ouyang D, Hadley D, Turakhia M, Wang P, Ashley E, Froelicher V, Perez M.Am J Cardiol. 2019 Mar 13. pii: S0002-9149(19)30304-2. doi: 10.1016/j.amjcard.2019.02.057.

Transthyretin Stabilization by AG10 in Symptomatic Transthyretin Amyloid Cardiomyopathy.Judge DP, Falk RH, Maurer MS, Shah SJ, Witteles RM, Grogan M, Selby VN, Jacoby D, Hanna M, Nativi-Nicolau J, Patel J, Rao S, Sinha U, Turtle CW, Fox JC, Heitner SB. J Am Coll Cardiol. 2019 Mar 12. pii: S0735-1097(19)33920-8. doi: 10.1016/j.jacc.2019.03.012.

A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles.Zhang JZ, Termglinchan V, Shao NY, Itzhaki I, Liu C, Ma N, Tian L, Wang VY, Chang ACY, Guo H, Kitani T, Wu H, Lam CK, Kodo K, Sayed N, Blau HM, Wu JC.Cell Stem Cell. 2019 Mar 6. pii: S1934-5909(19)30067-0. doi: 10.1016/j.stem.2019.02.015.

Rapid Genome Sequencing in the Critically lll.Buchan JG, White S, Joshi R, Ashley EA.Clin Chem. 2019 Mar 6. pii: clinchem.2018.293506. doi: 10.1373/clinchem.2018.293506.

Vitamin D with calcium supplementation and risk of atrial fibrillation in postmenopausal women.Boursiquot BC, Larson JC, Shalash OA, Vitolins MZ, Soliman EZ, Perez MV.Am Heart J. 2019 Mar;209:68-78. doi: 10.1016/j.ahj.2018.12.006.

Regional Variation in RBM20 Causes a Highly Penetrant Arrhythmogenic Cardiomyopathy.Parikh VN, Caleshu C, Reuter C, Lazzeroni LC, Ingles J, Garcia J, McCaleb K, Adesiyun T,Sedaghat-Hamedani F, Kumar S, Graw S, Gigli M, Stolfo D, Dal Ferro M, Ing AY, Nussbaum R, Funke B, Wheeler MT, Hershberger RE, Cook S, Steinmetz LM, Lakdawala NK, Taylor MRG, Mestroni L, Merlo M, Sinagra G, Semsarian C, Meder B, Judge DP, Ashley E.Circ Heart Fail. 2019 Mar;12(3):e005371. doi: 10.1161/CIRCHEARTFAILURE.118.005371.

Doxycycline and Ursodiol for ATTR Amyloidosis: Not Ready for Prime Time.Witteles RM.J Card Fail. 2019 Mar;25(3):154-155. doi: 10.1016/j.cardfail.2019.01.014.

Time based versus strain based myocardial performance indices in hypertrophic cardiomyopathy, the merging role of left atrial strain.Kobayashi Y, Moneghetti KJ, Bouajila S, Stolfo D, Finocchiaro G, Kuznetsova T, Liang D, Schnittger I, Ashley E, Wheeler M, Haddad F.Eur Heart J Cardiovasc Imaging. 2019 Mar 1;20(3):334-342. doi: 10.1093/ehjci/jey097.

Let Them Eat Cake.Rees J, Rodriguez F.Acad Med. 2019 Mar;94(3):320. doi: 10.1097/ACM.0000000000002544.

FEBRUARY

Serial Cardiac FDG-PET for the Diagnosis and Therapeutic Guidance of Patients With Cardiac Sarcoidosis.Ning N, Guo HH, Iagaru A, Mittra E, Fowler M, Witteles R.J Card Fail. 2019 Feb 27. pii: S1071-9164(19)30201-5. doi: 10.1016/j.cardfail.2019.02.018.

Association of Endothelin-1 with Accelerated Cardiac Allograft Vasculopathy and Late Mortality

Following Heart Transplantation.Parikh RV, Khush K, Pargaonkar VS, Luikart H, Grimm D, Yu M, Akada K, Honda Y, Yeung AC, Valantine H, Fearon WF.J Card Fail. 2019 Feb;25(2):97-104. doi: 10.1016/j.cardfail.2018.12.001.

Year in Review in Cardiac Electrophysiology.Tzou WS, Hussein AA, Madhavan M, Viswanathan MN, Steinberg BA, Ceresnak SR, Davis DR, Park DS, Wang PJ, Kapa S. Circ Arrhythm Electrophysiol. 2019 Feb;12(2):e007142. doi: 10.1161/CIRCEP.118.007142.

Association Between Female Corresponding Authors and Female Co-Authors in Top Contemporary Cardiovascular Medicine Journals.Ouyang D, Harrington RA, Rodriguez F.Circulation. 2019 Feb 19;139(8):1127-1129. doi: 10.1161/CIRCULATIONAHA.118.037763.

Association of Statin Adherence With Mortality in Patients With Atherosclerotic Cardiovascular Disease.Rodriguez F, Maron DJ, Knowles JW, Virani SS, Lin S, Heidenreich PA.JAMA Cardiol. 2019 Feb 13. doi: 10.1001/jamacardio.2018.4936.

One Size Does Not Fit All: Improving Recruitment and Retention of Women in Cardiovascular Device-Related Clinical Trials.Rodriguez F, Harrington RA.JACC Cardiovasc Interv. 2019 Feb 11;12(3):309-311. doi: 10.1016/j.jcin.2018.11.012.

Sex Differences in the Pursuit of Interventional Cardiology as a Subspecialty Among CardiovascularFellows-in-Training.Yong CM, Abnousi F, Rzeszut AK, Douglas PS, Harrington RA, Mehran R, Grines C, Altin SE,Duvernoy CS; American College of Cardiology Women in Cardiology Leadership Council (ACC WIC); Society for Cardiovascular Angiography and Interventions Women in Innovations (SCAI WIN). JACC Cardiovasc Interv. 2019 Feb 11;12(3):219-228. doi: 10.1016/j.jcin.2018.09.036.

Accuracy of Administrative Coding to Identify Reduced and Preserved Left Ventricular Ejection Fraction.Heidenreich PA, Natarajan S, Bahrami H. J Card Fail. 2019 Feb 10. pii: S1071-9164(18)31027-3. doi: 10.1016/j.cardfail.2019.01.019.

In Vivo Translation of the CIRPI System---Revealing Molecular Pathology of Rabbit Aortic Atherosclerotic Plaques.Zaman R, Yousufi S, Chibana H, Ikeno F, Long SR, Gambhir SS, Chin FT, McConnell MV, Xing L, Yeung A.J Nucl Med. 2019 Feb 8. pii: jnumed.118.222471. doi: 10.2967/jnumed.118.222471.

Body composition and atrial fibrillation: a Mendelian randomization study.Tikkanen E, Gustafsson S, Knowles JW, Perez M, Burgess S, Ingelsson E.Eur Heart J. 2019 Feb 5. doi: 10.1093/eurheartj/ehz003.

A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay.Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC.Circulation. 2019 Feb 5;139(6):799-811. doi: 10.1161/CIRCULATIONAHA.118.034624.

Donor-derived cell-free DNA predicts allograft failure and mortality after lung transplantation.Agbor-Enoh S, Wang Y, Tunc I, Jang MK, Davis A, De Vlaminck I, Luikart H, Shah PD, Timofte I, Brown AW, Marishta A, Bhatti K, Gorham S, Fideli U, Wylie J, Grimm D, Goodwin N, Yang Y, Patel K, Zhu J, Iacono A, Orens JB, Nathan SD, Marboe C, Berry GJ, Quake SR, Khush K, ValantineHA.EBioMedicine. 2019 Feb;40:541-553. doi: 10.1016/j.ebiom.2018.12.029.

Whole-heart coronary MR angiography using a 3D cones phyllotaxis trajectory.Malavé MO, Baron CA, Addy NO, Cheng JY, Yang PC, Hu BS, Nishimura DG. Magn Reson Med. 2019 Feb;81(2):1092-1103. doi: 10.1002/mrm.27475.

Diabetes-attributable mortality in the United States from 2003 to 2016 using a multiple-cause-of-death approach.Rodriguez F, Blum MR, Falasinnu T, Hastings KG, Hu J, Cullen MR, Palaniappan LP.Diabetes Res Clin Pract. 2019 Feb;148:169-178. doi: 10.1016/j.diabres.2019.01.015.

Complex heritability in cardiomyopathy.Ma N, Zhang SL, Wu JC.Nat Biomed Eng. 2019 Feb;3(2):87-89. doi: 10.1038/s41551-019-0353-z.

Secular trends in success rate of catheter ablation for atrial fibrillation: The SMASH-AF cohort.Perino AC, Leef GC, Cluckey A, Yunus FN, Askari M, Heidenreich PA, Narayan SM, Wang PJ, Turakhia MP.Am Heart J. 2019 Feb;208:110-119. doi: 10.1016/j.ahj.2018.10.006.

Cost-effectiveness of Canakinumab for Prevention of Recurrent Cardiovascular Events.Sehested TSG, Bjerre J, Ku S, Chang A, Jahansouz A, Owens DK, Hlatky MA, Goldhaber-Fiebert JD. JAMA Cardiol. 2019 Feb 1;4(2):128-135. doi: 10.1001/jamacardio.2018.4566.

JANUARY

Genetic Testing and Risk Scores: Impact on Familial Hypercholesterolemia.Sarraju A, Knowles JW.Front Cardiovasc Med. 2019 Jan 29;6:5. doi: 10.3389/fcvm.2019.00005.

Systems-Wide Approaches in Induced Pluripotent Stem Cell Models.Lau E, Paik DT, Wu JC. Annu Rev Pathol. 2019 Jan 24;14:395-419. doi: 10.1146/annurev-pathmechdis-012418-013046.

Transcatheter redirection of hepatic venous blood to treat unilateral pulmonary arteriovenous malformations in a Fontan circulation by short-term total exclusion of the unaffected lung.Adamson GT, Peng LF, Lui GK, Perry SB.Catheter Cardiovasc Interv. 2019 Jan 10. doi: 10.1002/ccd.28073.

Efficacy of Ablation Lesion Sets in Addition to Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation: Findings From the SMASH - AF Meta-Analysis Study Cohort.Cluckey A, Perino AC, Yunus FN, Leef GC, Askari M, Heidenreich PA, Narayan SM, Wang PJ, Turakhia MP.J Am Heart Assoc. 2019 Jan 8;8(1):e009976. doi: 10.1161/JAHA.118.009976.

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT,Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers

JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Circ Res. 2019 Jan 4;124(1):161-169. doi: 10.1161/CIRCRESAHA.118.314216.

Extended cardiac ambulatory rhythm monitoring in adults with congenital heart disease: Arrhythmia detection and impact of extended monitoring.Schultz KE, Lui GK, McElhinney DB, Long J, Balasubramanian V, Sakarovitch C, Fernandes SM, Dubin AM, Rogers IS, Romfh AW, Motonaga KS, Viswanathan MN, Ceresnak SR. Congenit Heart Dis. 2019 Jan 3. doi: 10.1111/chd.12736.

Rationale and design of a large-scale, app-based study to identify cardiac arrhythmias using a smartwatch: The Apple Heart Study.Turakhia MP, Desai M, Hedlin H, Rajmane A, Talati N, Ferris T, Desai S, Nag D, Patel M, Kowey P, Rumsfeld JS, Russo AM, Hills MT, Granger CB, Mahaffey KW, Perez MV. Am Heart J. 2019 Jan;207:66-75. doi: 10.1016/j.ahj.2018.09.002.

Safety and Efficacy of PCSK9 Inhibitors After Heart Transplantation.Moayedi Y, Kozuszko S, Knowles JW, Chih S, Oro G, Lee R, Fearon WF, Ross HJ, Teuteberg JJ,Khush KK.Can J Cardiol. 2019 Jan;35(1):104.e1-104.e3. doi: 10.1016/j.cjca.2018.11.004.

Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources.Köhler S, Carmody L, Vasilevsky N, Jacobsen JOB, Danis D, Gourdine JP, Gargano M, Harris NL, Matentzoglu N, McMurry JA, Osumi-Sutherland D, Cipriani V, Balhoff JP, Conlin T, Blau H, Baynam G, Palmer R, Gratian D, Dawkins H, Segal M, Jansen AC, Muaz A, Chang WH, Bergerson J, Laulederkind SJF, Yüksel Z, Beltran S, Freeman AF, Sergouniotis PI, Durkin D, Storm AL, Hanauer M, Brudno M, Bello SM, Sincan M, Rageth K, Wheeler MT, Oegema R, Lourghi H, Della Rocca MG, Thompson R, Castellanos F, Priest J, Cunningham-Rundles C, Hegde A, Lovering RC, Hajek C, Olry A, Notarangelo L, Similuk M, Zhang XA, Gómez-Andrés D, Lochmüller H, Dollfus H, Rosenzweig S, Marwaha S, Rath A, Sullivan K, Smith C, Milner JD, Leroux D, Boerkoel CF, Klion A, Carter MC,Groza T, Smedley D, Haendel MA, Mungall C, Robinson PN. Nucleic Acids Res. 2019 Jan 8;47(D1):D1018-D1027. doi: 10.1093/nar/gky1105.

Association of Educational Attainment and Cardiovascular Risk in Hispanic Individuals: Findings From the Cooper Center Longitudinal Study.Rodriguez F, Leonard D, DeFina L, Barlow CE, Willis BL, Haskell WL, Maron DJ.JAMA Cardiol. 2019 Jan 1;4(1):43-50. doi: 10.1001/jamacardio.2018.4294.

Nativity and Occupational Determinants of Physical Activity Participation Among Latinos.Echeverría SE, Divney A, Rodriguez F, Sterling M, Vasquez E, Murillo R, Lopez L.Am J Prev Med. 2019 Jan;56(1):84-92. doi: 10.1016/j.amepre.2018.07.036.

DECEMBER

Guidelines for Performing a Comprehensive Transesophageal Echocardiographic: Examination in Children and All Patients with Congenital Heart Disease: Recommendations from the American Society of Echocardiography.Puchalski MD, Lui GK, Miller-Hance WC, Brook MM, Young LT, Bhat A, Roberson DA, Mercer-Rosa L, Miller OI, Parra DA, Burch T, Carron HD, Wong PC.J Am Soc Echocardiogr. 2018 Dec 19. pii: S0894-7317(18)30475-9. doi: 10.1016/j.echo.2018.08.016.

Clinical and Genetic Determinants of Varicose Veins.

Fukaya E, Flores AM, Lindholm D, Gustafsson S, Zanetti D, Ingelsson E, Leeper NJ. Circulation. 2018 Dec 18;138(25):2869-2880. doi: 10.1161/CIRCULATIONAHA.118.035584.

Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes: Insights From the TRACER Trial.Ungar L, Clare RM, Rodriguez F, Kolls BJ, Armstrong PW, Aylward P, Held C, Moliterno DJ, Strony J, Van de Werf F, Wallentin L, White HD, Tricoci P, Harrington RA, Mahaffey KW, Melloni C. J Am Heart Assoc. 2018 Dec 18;7(24):e009609. doi: 10.1161/JAHA.118.009609.

Current Use of Hearts From Hepatitis C Viremic Donors.Moayedi Y, Fan CPS, Gulamhusein AF, Manlhiot C, Ross HJ,Teuteberg JJ, Khush KK.Circ Heart Fail. 2018 Dec;11(12):e005276. doi: 10.1161/CIRCHEARTFAILURE.118.005276.

Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity.Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Álamo JC, Mercola M, Wu JC. Nat Protoc. 2018 Dec;13(12):3018-3041. doi: 10.1038/s41596-018-0076-8.

Repair of Untreated Older Patients with Tetralogy of Fallot with Major Aortopulmonary Collaterals.Vaikunth S, Bauser-Heaton H, Lui GK, Wise-Faberowski L, Chan FP, Asija R, Hanley FL, McElhinney DB. Ann Thorac Surg. 2018 Dec 11. pii: S0003-4975(18)31799-5. doi: 10.1016/j.athoracsur.2018.11.016.

The Incremental Value of Right Ventricular Size and Strain in the Risk Assessment of Right Heart Failure Post - Left Ventricular Assist Device Implantation.Aymami M, Amsallem M, Adams J, Sallam K, Moneghetti K, Wheeler M, Hiesinger W, Teuteberg J, Weisshaar D, Verhoye JP, Woo YJ, Ha R, Haddad F, Banerjee D. J Card Fail. 2018 Dec;24(12):823-832. doi: 10.1016/j.cardfail.2018.10.012.

Promise and Perils of Big Data and Artificial Intelligence in Clinical Medicine and Biomedical Research.Rodriguez F, Scheinker D, Harrington RA.Circ Res. 2018 Dec 7;123(12):1282-1284. doi: 10.1161/CIRCRESAHA.118.314119.

Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells.Ma N, Zhang JZ, Itzhaki I, Zhang SL, Chen H, Haddad F, Kitani T, Wilson KD, Tian L, Shrestha R, Wu H, Lam CK, Sayed N, Wu JC. Circulation. 2018 Dec 4;138(23):2666-2681. doi: 10.1161/CIRCULATIONAHA.117.032273.

Ventricular mechanics in adolescent and adult patients with a Fontan circulation: Relation to geometry and wall stress.Rösner A, Khalapyan T, Pedrosa J, Dalen H, McElhinney DB, Friedberg MK, Wu JC. Echocardiography. 2018 Dec;35(12):2035-2046. doi: 10.1111/echo.14169

Sex Disparities in Authorship Order of Cardiology Scientific Publications.Ouyang D, Sing D, Shah S, Hu J, Duvernoy C, Harrington RA, Rodriguez F. Circ Cardiovasc Qual Outcomes. 2018 Dec;11(12):e005040. doi:10.1161/CIRCOUTCOMES.118.005040.

Radiolabeled Duramycin: Promising Translational Imaging of Myocardial Apoptosis.Wu JC, Qin X, Neofytou E. JACC Cardiovasc Imaging. 2018 Dec;11(12):1834-1836. doi: 10.1016/j.jcmg.2017.12.009.

27-Year-Old Man with a Positive Troponin: A Case Report.

Manjunath L, Yeluru A, Rodriguez F.Cardiol Ther. 2018 Dec;7(2):197-204. doi: 10.1007/s40119-018-0120-3.

Grading cardiac response in AL amyloidosis: implications for relapse and survival.Eckhert E, Witteles R, Kaufman G, Lafayette R, Arai S, Schrier S, O'Shaughnessy M, Liedtke M.. Br J Haematol. 2018 Dec 19. doi: 10.1111/bjh.15717.

ClinPhen extracts and prioritizes patient phenotypes directly from medical records to expedite genetic disease diagnosis.Deisseroth CA, Birgmeier J, Bodle EE, Kohler JN, Matalon DR, Nazarenko Y, Genetti CA, Brownstein CA, Schmitz-Abe K, Schoch K, Cope H, Signer R; Undiagnosed Diseases Network,Martinez-Agosto JA, Shashi V, Beggs AH, Wheeler MT, Bernstein JA, Bejerano G. Genet Med. 2018 Dec 5. doi: 10.1038/s41436-018-0381-1.

Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential.van Mil A, Balk GM, Neef K, Buikema JW, Asselbergs FW, Wu SM, Doevendans PA, Sluijter JPG.Cardiovasc Res. 2018 Dec 1;114(14):1828-1842. doi: 10.1093/cvr/cvy208.

Assessing the Relationship Between American Heart Association Atherosclerotic Cardiovascular Disease Risk Score and Coronary Artery Imaging Findings.Li Y, Zhu G, Ding V, Jiang B, Ball RL, Ahuja N, Rodriguez F, Fleischmann D, Desai M, Saloner D, Saba L, Wintermark M, Hom J. J Comput Assist Tomogr. 2018 Nov/Dec;42(6):898-905. doi: 10.1097/RCT.0000000000000823.