Health & life sciences in the Helsinki region

THE HELSINKI REGIONHEALTH TECH & LIFE SCIENCESOPPORTUNITIES TO DEVELOP, COLLABORATE & GROW

Picture © Jussi Hellsten / Visit Helsinki

THE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

HELSINKI HAS ALIFE SCIENCESTALENT POOLOF AROUND29 000 PEOPLE

EXPORTS OF FINNISHHEALTH TECHNOLOGYGREW 8.3% TO A NEW RECORD OF €1.8BILLION IN 2014

A TOP-10 RESEARCHLOCATION GLOBALLY IN 34 OUT OF 39 FIELDS OF MEDICINE

AMONG THE 1ST

CHOICE COUNTRIESFOR STARTINGmHEALTH BUSINESSIN EUROPE

HELSINKI IS HOME TO TWO WORLD-CLASSUNIVERSITIES:UNIVERSITY OF HELSINKI AND AALTO UNIVERSITY

FINLAND HASOVER 300COMPANIESOPERATING INHEALTH TECH

THE LEADING AREAS OF FINNISH EXPERTISE IN HEALTH TECH & LIFE SCIENCES INCLUDE ONCOLOGY, CLINICAL NEUROLOGY, GASTROENTEROLOGY, CARDIOLOGY, EMBRYOLOGY AND NUTRITION AND DIETETICS

FACTS & FIGURES

FINLAND HAS MOST PROFESSIONALS WORKING IN R&DINTHE WORLD PER 1M POPULATION (7482)

FINLANDIS RANKED3RD IN GLOBAL INNOVATIONIN 2015

THE CORPORATE LIFE SCIENCES SECTORIN THE HELSINKI REGION HAS PERSONNELOF 21 000 AND REVENUES OF€8.5 BILLION (2014).

THE HELSINKI REGION HEALTH TECH & LIFE SCIENCES ECOSYSTEM OVERVIEW

CITIESHELSINKIVANTAAESPOO

HELSINKIBUSINESS HUBCAN HELP YOU

CONNECTWITH…

TALENTHEALTH CARE SPECIALISTSENGINEERS – BIG DATA & SOFTWARER&D SCIENTISTSACADEMIC SCIENTISTSSALES & MARKETING

COMPANIESMNC’SSPECIALIZED HEALTH COMPANIESSTARTUP ECOSYSTEMADVANCED SCIENTIFIC COMMUNITIES

UNIVERSITIESUNIVERSITY OF HELSINKIAALTO UNIVERISTYLAUREA UNIVERISTY OF APPLIED SCIENCESMETROPOLIA UNIVERISTY OF APPLIED SCIENCES

RESEARCH & INDUSTRY ORGANIZATIONSHUS / HUCHHYKS INSTITUTEHEALTH CAPITAL HELSINKIVTTTEKESSITRAFIHTAPIF

WORLD’S MOSTADVANCED TESTBEDNATIONAL BIOBANKSHEALTH DATA REGISTRIESLARGE SAMPLE RESEARCH RESULTSPILOTING OPPORTUNITIESPUBLIC/PRIVATE COOPERATION

ACCESS TOOTHER MARKETSEU CERTIFICATIONSNATIONAL PROGRAMS TOGLOBALIZE, R&D AND GROWTH

TALENT – EXPERTISE ACROSS ALL KEY SPECIALTIESTHE LARGEST AREAS E.G. BIOCHEMISTRY, MOLECULAR BIOLOGY AND GENETICS


21 000

17 700

14 100 14 000 13 10011 700 10 700

7 200 6 400 6 400 6 200 5 7004 300

2 700 1 900

0

5 000

10 000

15 000

20 000

25 000

FINLAND - EXPERTISE IN SPECIALIST LIFE SCIENCES SKILLS

Source: Oxford Intelligence 2014

A BLEND OF EXPERIENCE AND NEW TALENT42 % HAVE MORE THAN 5 YEARS OF EXPERIENCE



31%

28%

31%

10%

Less than 2 years

2-5 years

5-10 years

10 years or more

GREATER HELSINKI - YEARS OF EXPERIENCE INA TECHNICAL LIFE SCIENCES ROLE

48%

29%

13%

8% 2%

GREATER HELSINKI - EDUCATION LEVEL OFLIFE SCIENCES PROFESSIONALS

Master's Degree

Doctorate/Licentiate

Bachelor's Degree

Vocational education

High school

RICH CROSS-INDUSTRY EXPERTISEALMOST 40% OF LIFE SCIENCES PROFESSIONALS HAVE ALSO WORKED IN ANOTHER SECTOR



39%

34%

34%

33%

Food science

Engineering

ICT

Cleantech

FINLAND - % OF LIFE SCIENCES PROFESSIONALS WITH OTHER TECHNICAL SKILLS

OVER 3000 LIFE SCIENCES GRADUATES ANNUALLY FINLAND UNIVERSITY GRADUATIONS IN LIFE SCIENCES 2015:


Source: Finnish National Board of Education

FIELD BACHELOR'S ORMASTER'S DEGREE

DOCTOR'S,LICENCIATE'S OR OTHER

SPECIALIST DEGREETOTAL

DENTISTRY 146 42 188

MEDICINE 625 848 1 473

PHARMACY 395 29 424

HEALTH SCIENCE 732 41 773

VETERINARY MEDICINE 139 45 184

TOTAL 2 037 1 005 3 042

SELECTED ECOSYSTEM SUCCESS STORIESTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

Noona is a mobile service, created with leading experts in HUS Oncology Department, which allows cancer clinics and hospitals to monitor patients’ health development during and after a course of cancer treatment. The cooperation will open new doors for Noona in MSD's international client network and promote its faster move to global markets.

NOONAHEALTHCARE INR&D CO-OPWITH MSD

THERMO FISHERSCIENTIFICACQUIREDFINNZYMES

BAYER’SNORDICHEADQUARTERS

GE ACQUIREDINSTRUMENTARIUM

BLUEPRINTGENETICSRAISES FUNDING FORUS EXPANSION

MEDISAPIENS COLLABORATESWITH GSK &BAYER

In 2010 Thermo Fisher Scientific acquired the Finnish Finnzymes, whose extensive know-how in PCR and qPCR technologies as well as collaboration with academic and industry research led to several innovative commercial products. Today Thermo Fisher has a Finnish R&D centre in Vantaa and production facilities in Joensuu..

In 2011 German pharmaceutical company Bayer established its Nordic and Baltic headquarters in Espoo, which is now home to one of Bayer’s largest clinical research units. Bayer’s focus areas in Finland include use of polymers in medicine dosing, as well as contraceptives and hormonal treatment. Bayer also has a manufacturing site in Turku.

In 2003 GE Healthcare acquired Instrumentarium, a large Finnish medical technology company. Instrumentarium specialized in patient monitoring, anesthesia and imaging technologies. Today GE’s unit in Helsinki is one of it’s global centers of research and development in patient monitoring, anesthesia and healthcare information systems.

Blueprint Genetics provides genetic diagnostics of rare diseases based on Next-Generation Sequencing (NGS), targeted for hospitals and research groups. The aim is to disrupt the market by decreasing the price level of genetic diagnostics significantly while increasing quality and adding clinical insight to the results statements.

MediSapiens and Bayer developed a platform for genomics data management and analysis in Oncology. The platform enables Bayer to more effectively utilize genomics data in oncology research. In collaboration with GSK, MediSapiens presented an entirely new pipeline for performing fast and powerful Pan-Cancer identification of fusion genes.

UNIVERSITIES & RESEARCHTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

AALTO UNIVERSITYhttp://www.aalto.fi/en/• 6 schools, 20 000 students and 4 500

employees, of which over 400 professors• Health and wellbeing (H&W) is one of the

university’s seven key research areas.• Six subareas of H&W: Biomedical Engineering,

Neuroscience and Neurotechnology, Biotechnology, Biomaterials, and Chemistryin H&W, Digital Health, Management in H&W and H&W Architecture and Design

• Expertise includes medical and wellness devices, data science and software engineering for healthcare and wellbeing, biomaterials, biotechnology, and pharmaceuticals

• Aalto Health Platform is a collaborative program for joint work with partner organizations in H&W. Its role is to support H&W research activities and facilitate technology transfer towards innovations and startups and the broader high technology industries

laurea UNIVERSITY OF APPLIED SCIENCEShttps://www.laurea.fi/en• 7700 students and 520 staff members• 4 fields of studies: Business, Nursing, Social

Services and Hospitality Management• The strategic goal is to be an international

developer of well-being and competitiveness in the Helsinki metropolitan area in 2020.

• Learning through research, reflection and development activities carried out together with teachers, other students and workplace actors.

• Laurea's fields of expertise in RDI activities focus on expertise in nursing work and coping at home, service business activities, security and social responsibility, as well as entrepreneurship and innovations.

• Laurea has created the Learning by Developing (LbD) model as a tool for reaching its strategic goals and implementing them in practice at the Laurea Living Labs Network. Living labs are authentic environments that clients and users identify as their own, where innovation is utilized and accepted as part of one’s own life or as an element that reform one’s work.

HELSINKI UNIVERISTY /HELSINKI UNIVERISTY HOSPITAL - HUS https://www.helsinki.fi/en• The leading teaching hospital in Finland• 2,3 million visits annually, 22 000 employees

and revenues of 2.0 billion euros• one of the biggest PACS archive in the world• more than 3 million samples in HUS biobank• several specialties – such as oncology,

pediatric cardiac surgery and transplantations– where treatment outcome is among the best in the world

• ranked among top 10 in Europe regarding academic medical research

• active corporate co-operation in acid-testing, evaluation, challenging, simulation, user panels, pre-clinical and clinical trials, testbed services, usability-testing and development, and many other services

• For medtech, pharma and other companies’ access point to HUS services is via Health Capital Helsinki (more on HCH next page)

UNIVERISTIES & RESEARCHTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

Clinical Research Institute Helsinki UniversityCentral Hospitalhttp://www.hyksinstituutti.fi/index.php?page=106&lang=2The company conducts contract-based research in the entire Hospital District of Helsinki and Uusimaa (HUS)• The doctors and nursing staff are highly

qualified and have the full support of the Faculty of Medicine in the University of Helsinki.

• Continuous collaboration with University Hospitals in the EU and the USA and the international network of awarded scientists guarantee that HUS has the latest information of the best practices in all fields of medicine.

Health innovation village at gehttps://www.facebook.com/healthinnovlge• Digital Health ecosystem hub and co-

working space• Houses over 25 startup companies• The home of StartUp Health Finland, the

largest Digital Health accelerator in the world

TECHNICAL RESEARCH CENTRE OFFINLAND - VTT http://www.vttresearch.com/• VTT is the leading research company in the

Nordic countries• 2,600 personnel, annual budget of €277M• Helping customers develop new

technologies and service concepts in the areas of digital health (health monitoring, human data analysis and application &service design), wearable technologies and diagnostics

• one of the largest R&D programs for optical, electrical, biological and molecular sensing solutions in Europe

BIOMEDICUMhttp://www.biomedicum.com/index.php?page=105&lang=2• startup physical space, located in HUS,

allows companies in health area research to do collaboration with HUS

• Concentrated on helping health companies grow and develop their business

• HCH provides easy collaboration & connections

through public & private sectors – one entry point to

get in touch with the entire life sciences ecosystem in

the Helsinki region:

• Research expertise, universities and biobanks

• Product & business development

• Life science and health tech’s innovations, clinical research & its personnel

• Interesting startups and growth companies

• Funding organizations (e.g. Tekes has reserved 2,5M€ for product development in this area)

• Marketing and communication channels

• Co-creation and co-development with the Health Capital Helsinki alliance, its wide network and access to large population

HEALTH CAPITAL HELSINKIhttp://www.healthcapitalhelsinki.fi/en/

OTHER ORGANIZATIONSTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

THE FINNISH HEALTH TECHNOLOGY ASSOCIATION – FIHTAwww.finnishhealthtech.fi• Association for all Finnish companies in the

health technology business.• The purpose is to represent the growing

Finnish health tech sector and monitor the common interests of its member companies to improve their business environment.

• FiHTA forms a substantial forum for communication, cooperation and networking. It maintains firm contacts with its interest groups and customers in the health sector.

THE FINNISH FUNDING AGENCY FOR INNOVATION – TEKEShttp://www.tekes.fi/en/• Tekes is a publicly funded expert

organization for financing research, development and innovation in Finland

• Boosts wide-ranging innovation activities in research communities, industry and service sectors and is an active game builder in selected fields, incl. wellbeing and health.

• Offers innovation funding and services to internationalizing companies and support efforts to attract foreign investment in Finland.

• The Bits of Health programme pursues to make Finland a renowned expertise and business hub for digital health• The programme offers funding for

research, development and innovation projects. Co-creation with end-users and piloting in early developmental phase in real user environments in encouraged.

PHARMA INDUSTRY FINLAND - PIF http://www.pif.fi/en• Organization bringing together innovation-

driven companies based in life science research and development.

• Focus on lobbying, external communications and partnership building and internal PIF operations and related communications

THE FINNISH INNOVATION FUND – SITRAhttp://www.sitra.fi/en• Public fund aimed at promoting new

operating models and stimulate business that aims at sustainable well-being.

• Carries out practical experiments, compiles cross-boundary networks and develops and finances business operations

• Operations are funded from the returns of endowment capital and capital investments, which means that Sitra receives no funding from taxes or the state budget.

EASY ACCESS TO EU MARKETSTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

• CE marking signifies that products sold in the European Economic Area (EEA) have been assessed to meet high

safety, health, and environmental protection requirements.

• CE certification also helps to achieve a quicker path for FDA approval

• Better private – public partnerships provides a strong baseline for entry into larger EU markets such as the UK

market

• The high quality of our public health care system and cost-effectiveness

• National R&D and Growth programs to reach other markets: Asia, North America, Africa

THE MOST ADVANCED T EST BED IN T HE WORLD

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H I G H L E V E L E D U C AT I O N

H I G H W I L L I N G N E S S T O PA R T I C I PAT E

T R U S T I N A U T H O R I T I E S

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S O C I A L S E C U R I T Y N U M B E R

T H E B I O B A N K A C T - R E C A L L I N G M A D E E A S Y

P R I VA C Y T E R M S & I N F O R M E D C O N S E N T P O L I C Y

A C T I O N T O WA R D S N AT I O N A L O P E R AT O R F O R H E A LT H A N D W E L L B E I N G DATA - D I G I TA L H E A LT H H U B 2 0 1 7

HIGH-QUALITY HEALTH DATA REGISTRIESTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

THL = National Institute of Health and WelfareETK = The Finnish Kidney and Liver AssociationKELA = Social Insurance InstitutionSTAT = Statistics FinlandFIOH = Finnish Institute of Occupational HealthFIMEA = National Agency for MedicineETK = Finnish Centre for PensionsVRK = Central Population Register

NAME OF REGISTER DATA INCLUDED IN REGISTER KEEPERESTABLISHED IN COMPUTER

FORMAT

Hospital Discharge Register (HILMO) Homes and institutions for the mentally disabled, including information on treatment THL 1967

Finnish Registry for Kidney Diseases Diseases, type of treatment, and laboratory tests ETK 1964

Cancer Register Cancer patient information from hospitals, pathology, laboratory measurements etc. THL 1953

Finnish Register of Visual Impairment Patient’s visual ability THL 1983

National Infectious Diseases Register Detailed information on cases in infectious diseases THL 1989

Register of Congenital Malformations Infants and foetuses THL 1963

Drug Reimbursement Registers Disease that is being treated and medication used KELA 1967

Medical Birth Register Information on all births in Finland, from gestation week 22+0 or birthweight 500g THL 1987

Cause-of-Death Register Intermediate case of death and contributing causes of death STAT 1969

Register on Occupational Disease Diagnosis of occupational disease FIOH 1964

Drug Surveillance Register FIMEA 1982

National Sickness Insurance Social benefit information KELA 1967

Register on Pensions Work pension information, age of individual, type of pension ETK 1962

Finnish Employment Register Work in private sector, work as entrepreneur and work without pay ETK

Central Population Register Relations (stillbirths are not registered) VRK 1973

Register on Social Assistance THL 1985

Child Welfare Register Individual-level information on children taken into custody THL 1991


DATA REGISTRIES – CASE FINNISH CANCER REGISTRYTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

• The Finnish Cancer Registry maintains a nation-wide database on all cancer cases in Finland going back to 1953. It is also

an internationally active institute for statistical and epidemiological cancer research.

• The Finnish Cancer Registry and its staff are highly recognized both among the scientific community and the health care

sector in Finland. The output of the Registry is widely used in research, administration, and health education on all levels.

• All this improves the quality of the registration activity and is likely to contribute towards complete coverage and high

data accuracy in the Registry.

• Every year about 80 scientific papers are published based on the data and know-how of the Finnish Cancer Registry

• More than 22,000 new cases of cancer are currently registered each year, plus some 4,500 basal cell carcinomas of the

skin and smaller amounts of some other lesions.

• The Registry file is annually matched with the Cause of Death Register located at Statistics Finland, and regularly linked

with Central Population Register.Source: Cancer Society of Finland

HELSINKIHEALTH TECH & LIFE SCIENCES

FOCUS AREAS

GENOMICSPRECISION MEDICINE

CANCER TREATMENTMED TECH

DIGITALHEALTH


MED TECH

MED TECHTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

• Health technology is Finland’s now largest hi-tech sector (nearly half of all hi-tech exports) and medical

equipment its fastest growing field - exports of medical equipment rose over 10 % to €1.3 billion in 2014

• Healthtech exports have increased at an average annual rate of 9 % for two decades

• Product trade statistics actually understate the export prowess of Finnish healthtech, as several

multinational companies have large R&D operations in Finland without associated product

manufacturing in Finland

• Recent notable activities in med tech in the Helsinki region include e.g. the founding of GE Health Village and

Fischer Scientific’s Acquisition of Instrumentarium, tying the excellence in Engineering with the Health Sciences

• Helsinki offers many collaboration opportunites in med tech, such as with Aalto University and HYKS

institute

• Wearables & sensor development, Opticals – Helsinki’s expertise have attracted MNCs that are looking

for top-notch engineers with tight R&D collaboration

1ST MEDICAL DEVICE CYBER SECURITYPROJECT IN THE WORLD


• Medical device cyber security studies on how to deal with the development of medical devices for optimum

performance while deterring system-wide attacks

• TEKES (The Finnish Funding Agency for Innovation) funded platform, with strong ties to HUS and the

government

• The 1st noted Governmentally Supported Project that focuses on the effects of a changing global

climate where cyberterrorism can and has happened

• Looking for Global Partners to collaborate on the industry standards

EXAMPLES OF COMMERCIAL R&D IN MED TECHTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

COMPANY REVENUE M€ PERSONNEL DESCRIPTION

GE Healthcare 305 659Finnish HQ in Helsinki is one of GE’s patient monitoring R&D centers. Also anesthesia and healthcare software development. Home to GE Health Innovation Village, a campus for healthtech startups.

Thermo Fisher Scientific 143 697 Product development, sales and marketing in Vantaa, production in Joensuu. Finnish R&D focuses on analytic devices, chemicals, reagents and other supplies for laboratory environments.

Philips Medical Systems MR Finland N/A 80 Part of the global Philips Healthcare group. Vantaa site develops innovative minimally invasive therapy solutions based on Magnetic Resonance Imaging guidance.

Varian Medical Systems 21 128 Varian Medical Systems Finland is located in Helsinki and designs and develops state-of-art radiation therapy treatment planning products.

Planmeca Group 750 2670Finnish Planmeca is a global leader in digital dental units, 2D and 3D imaging devices, and comprehensive CAD/CAM and software solutions. HQ in Helsinki.

Palodex Group 133 337Finnish Palodex is nowadays part of US based Danaher Corporation. Designs, manufactures and markets devices for dentomaxillofacial, ENT (ear, nose and throat) and head and neck imaging for a global customer base.

Sartorius Biohit Liquid Handling 30 166Finnish Biohit sold its liquid handling business to Sartorius in 2011. The majority of electronic pipettes used worldwide are developed and manufactured by Sartorius Biohit Liquid Handling. Finnish HQ in Helsinki, factory in Kajaani.

CANCER TREATMENT

CANCER TREATMENTTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

• Cancer research is one of Finland’s major competitive advantages in the global research field

• The Helsinki University Central Hospital Comprehensive Cancer Center (HUCH CCC) is the first Nordic

institution accredited by the Organization of European Cancer Institutes (OECI).

• Establishing a National Cancer Centre took a major step forward in April 2016 with the Government’s decision

to provide funding for this purpose during the next four years

• Innovative treatment platforms - Not just looking at the patient from the clinical aspect, but also

emotional, thus treating the entire patient, not just the disease

• Partnerships with public agencies and HUCH are made very easy to reach into the research ecosystem and as a

testbed

• Ease of doing clinical trials with one of Europe’s biggest Patient Care Databases, that will be

combined in the next few years under a new law with physical samples in one of the most complete

Biobanks in the world

EXAMPLES OF INTERNATIONAL COMMERCIAL R&DIN CANCER TREATMENT



Bayer 740 800Nordic HQ in Espoo, production in Turku. Espoo is home to one of Bayer’s largest clinical research units. Finnish expertise areas include use of polymers in medicine dosing as well as contraceptives and hormonal treatment.

Novartis 133 184 Located in Espoo – pharmaceutical sales and clinical research. Additionally, Sandos AS sells generic drugs and Alcon Nordic AS eye surgery products.

Pfizer 132 126Helsinki site focuses on oncology, vaccines and consumer healthcare and conducts clinical research. On their website Pfizer state that one of their missions is to increase life sciences sector investment in Finland.

Janssen-Cilag (Johnson & Johnson) 130 141 Sales organization of one of the world’s largest pharma companies. Espoo.

GlaxoSmithKline 112 110GSK implements clinical medicine and vaccine research together with its Finnish partners. The company’s research team in Finland consists of 20 professionals who work in co-operation with academic research institutions, hospitals and private medical services providers. Espoo.

Santen 105 459Santen’s European R&D centers are located in Tampere and France. Clinical research and marketing office in Helsinki. Tampere also has a production site. Focus areas are ophthalmic and anti-rheumatic pharmaceuticals.

Roche 94 90 Especially focused on personalized medicine, cancer treatment, arthritis, neurological illness. 30 ongoing clinical research projects in Finland. Espoo.

Sanofi 90 89 Sales office of French pharma company, located in Helsinki. European R&D in France and Germany.

AbbVie 62 94 Biopharmaceuticals sales organization located in Espoo.

EXAMPLES OF INTERNATIONAL COMMERCIAL R&DIN CANCER TREATMENT



AstraZeneca 61 53 Biopharmaceuticals sales organization located in Espoo. HQ in London and head R&D facility in Södertälje, Sweden.

MSD (Merck & Co) 30 109Espoo sales and marketing organization focusing on cardiovascular diseases, type 2 diabetes, cancer, osteoarthritis, women’s health and infectious diseases. Also conducts around 30 clinical trials in Finland annually.

Merck 18 20Sales organization of the German pharma and chemicals company. Therapeutic areas in Merck Finland’s pharma product area include Oncology, Multiple Sclerosis, Fertility, Endocrinology (growth disorders and diabetes) and Cardiovascular Diseases.

Amgen 15 35 Biopharmaceuticals sales organization located in Espoo.

Eli Lilly 13 65 Global pharma company focused on diabetes, osteoporosis, cancer, CNS and heart disease. Sales and marketing in Helsinki.

EXAMPLES OF FINNISH COMMERCIAL R&DIN CANCER TREATMENT



Orion Oyj 1 017 3 493HQ in Espoo, most of R&D and manufacturing in Finland. Core R&D therapy areas include central nervous system (CNS) disorders, oncology and respiratory. Orion Diagnostica focuses on diagnostic test systems.

Biohit Oyj 4,6 50 Globally operating Finnish biotech company. Develops diagnostic tests for the early detection and prevention of diseases of the gastrointestinal tract.

Glykos Finland 3,4 N/A.(2013: 38)

Analytical services to characterize glycans. Partners with pharmaceutical companies in new molecules development. Applications in e.g. cancer treatment.

PILOTING OPPORTUNITIESCASE – HELSINKI UNIVERSITY CENTRAL HOSPITALCOMPREHENSIVE CANCER CENTER (HUCH CCC)


• The goal of the HUCH CCC’s “Kertomalla paranee” (eng. =

“improve by telling”) project is to holisitically develop cancer

treatment and patients’ quality of life.

• The project first gathers improvement suggestions openly

via #kertomallaparanee webpage & campaign, out of which

HUCH CCC then chooses and refines ideas to start co-

developing with companies.

• The project gives an unique opportunity for companies

operating in the area to co-create and test their product

directly with the future client & end-users.

GENOMICS & PRECISION MEDICINE

COU NTRIES W ITH B IOBANKS

UNIVERSAL HEALTHCARE

UNIQUE SOCIAL SECURITY NUMBER SYSTEM

ISOLATED POPULATION

RECALL ING MADE EASY (BIOBANK ACT + SOS IAL SECURITY NUMBER)

COUNTRIES W ITH B IOBANKS

U NIVERSAL H E ALTHC AR E

U NIQUE SOC IAL S E C UR ITY NUM BER SYSTEM

I SOLATED POPULATION

RECALL ING M ADE E ASY ( BI OBANK AC T + SOS IAL SECURITY NUMBER)

THE BEST BIOBANKS IN THE WORLDTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES




U NIVERSAL HEALTHCARE

UNIQUE SOCIAL SECURITY NUMBER SYSTEM

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COUNTRIES WITH B IOBANKS

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UNI QUE SOC IAL SEC URI T Y NUM BER SYSTEM

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COUNTRIES W ITH B IO B ANKS

UNIVERSAL H E ALTH CARE

UNIQUE SOCIAL S E CURITY NUMBER SYST EM

ISOLATED PO P UL ATION

RECALL ING M AD E E ASY (BIOBANK ACT + SOSIAL SECURITY NUMBER)


CASE EXAMPLE OF ONE FINNISH BIOBANKTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

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1 3 0 0 0 0 I N D I V I D U A L SF R O M P O P U L AT I O N C O H O R T S

7 0 0 0 0 I N D I V I D U A L S F R O M D I S E A S E C O L L E C T I O N S


THE SISU PROJECT (SEQUENCING INITIATIVE SUOMI)THE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

2 0 0 0 0 0 I N D I V I D U A L S

4 % O F T H E P O P U L AT I O N

7 3 0 0 0 G E N O M E W I D E G E N O T Y P E DATA

> 2 6 0 0 0 G E N O M E O R E XO M E S E Q U E N C E S

P O P U L AT I O N C O H O R T S

E X T E N S I V E H E A LT H , P H E N O T Y P E , M E TA B O L O M I C DATA

D I S E A S E S P E C I F I C C O L L E C T I O N S

N AT I O N A L B I O B A N K

P O P U L AT I O N S P E C I F I C G E N O T Y P E

R E F E R E N C E DATA B A S E

I M P U TAT I O N


HIGH WILLINGNESS TO PARTICIPATETHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

95 % OF SAMPLE DONATORS HAVE G IVEN CONSENT OF THEIR SAMPLES

85 % OF 340 000 WOMENPARTIC IPATED IN SCR EEN I N G OF BREASTCANCER

> 85 000 PEO PLE PAR TI C IPAT ED IN VACCINATION R ES EAR CH (2 01 0)

> 30 000 PEOPLE VOLUNTEERED FOR 284 D IFFERENT MEDICAL RESEARCHS (2 013 )


GENOMICS & PRECISION MEDICINETHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

• Biobank Helsinki – 50 years of collecting samples +

continuously new ones (& legislation to support)

• Data sequencing in action

• Big data ecosystem:

• i.e. Blueprint Genetics, BC platforms, Medisapiens

• High global interest already for Finnish genomics testbed

• Ideal development location for precision medicine as well

• Finland with its small population is a good test case location for EU markets

Researchinstitution

Focusareas

Institute for Molecular Medicine Finland (FIMM)

human genomics and personalized medicine

Biocentrum Helsinki molecular biology, experimental biomedicine, biotechnology

University of Helsinki -Faculty of Biosciences

genetics, bioinformatics

STRENGHTS IN GENOMICS & PRECISION MEDICINETHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

• Reliable and comprehensive registries and population databases since the 1950’s

• Nationwide electronic patient data repository and MyData

• Strong tech capabilities

• Relatively isolated gene pool

• Existence of a legal framework for biobanking and willingness to further develop the legislative

framework

• Strong tradition of genetics research & active research in the field of personalized medicine

• Very positive attitude of the population towards research

BY THE YEAR 2020, GENOMIC DATA WILL BE EFFECTIVELY USED IN HEALTHCARE AND IN THE PROMOTION OF HEALTH AND WELLBEING

• Ethical principles and legal framework are available

for the application of genomics

• Genomics research is integrated into healthcare

• Healthcare workforce have the knowledge and skill

to apply genomic information

• Informatics infrastructure is in place for effective

application of genomics

• Genomic information is widely used in healthcare

to meet the needs of individuals and the population

• People understand and are able to make effective

use of genomic information to improve their own

health

• In genomics, Finland is an attractive research and

innovation environment for collaboration and

investment


GENOMICS & PRECISION MEDICINE COMPANY ECOSYSTEMTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

COMPANY ESTABLISHED DESCRIPTION

BC platforms 1997 genomic data analysis

Genoscoper 1995 DNA-based animal diagnostics

MediSapiens 2009 gene expression database

Blueprint Genetics 2008 genomic data analysis, big data

Euformatics 2010 genomic data analysis

Oligomer 2004 synthetic DNA and reagents

Significo Research 2012 genomic data analysis

Biomedicum Genomics 2007 genomic data analysis

DIGITAL HEALTH

DIGITAL HEALTHTHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES

• Healthy ecosystem that contains mobile apps development, wearables and professionals that are

willing to test them in real-world environments

• Use of digital health and development to enable more self-care and independence

• Inclusion of Chronically Conditions in Digital Health for better Quality of Life

• Digital Health Applications geared to Geriatric Populations

• Use of Digital Health as a Holistic view of Treatment

DIGITAL HEALTH –THE ISAACUS PROJECThttp://www.sitra.fi/en/well-being/well-being-data

• “Isaacus – the digital health hub”, is a project focused on gathering and co-ordinating well-being data.

• From a single access point, Isaacus will provide data concerning well-being – such as patient, demographic and lifestyle data – and open data gathered from various registers and sources. When gathering and processing this data, special attention will be paid to the protection of privacy, data security and the individual as the key decision-maker

• Citizens will be able to view their own data and use it to maintain their personal well-being. Unhindered use of data generated by society will lead to better care and treatment, boost the service production and research, and help the business sector to regenerate.

• The work will be done in extensive collaboration with the public and private sectors and NGOs.

EXAMPLES OF COMMERCIAL R&D IN DIGITAL HEALTH



Mawell 24 47 HQ in Oulu, office in Helsinki and other Nordic capitals. Healthcare software.

Whitelake Software Point 11 98 Laboratory informatics, healthcare, biobanking and lab intelligence software.

Mediconsult 7,5 67 Healthcare software solutions. Located in Helsinki.

Medixine 1,6 15 Telehealth solutions. Located in Espoo.

EXAMPLES OF COMMERCIAL R&D IN PHARMATHE HELSINKI REGION HEALTH TECH & LIFE SCIENCES


Bayer 740 800 Nordic HQ in Espoo, production in Turku. Espoo is home to one of Bayer’s largest clinical research units. Finnish expertise areas include use of polymers in medicine dosing as well as contraceptives and hormonal treatment.

GlaxoSmithKline 120 110GSK implements clinical medicine and vaccine research together with its Finnish partners. The company’s research team in Finland consists of 20 professionals who work in co-operation with academic research institutions, hospitals and private medical services providers. Espoo..

Medix Biochemica 15 92Finnish biotechnology company that develops, produces and markets monoclonal antibodies, antibody services and recombinant antigens for IVD industry as well as diagnostic rapid tests. Building IVD and pharma network in Finland with Tekes funding.

MSD (Merck & Co) 30 109 Espoo sales and marketing organization focusing on cardiovascular diseases, type 2 diabetes, cancer, osteoarthritis, women’s health and infectious diseases. Also conducts around 30 clinical trials in Finland annually.

Novartis 133 184 Located in Espoo – pharmaceutical sales and clinical research. Additionally, Sandos AS sells generic drugs and Alcon Nordic AS eye surgery products.

Orion Oyj 1 017 3 493 HQ in Espoo, most of R&D and manufacturing in Finland. Core R&D therapy areas include central nervous system (CNS) disorders, oncology and respiratory. Orion Diagnostica focuses on diagnostic test systems.

Pfizer 132 126 Helsinki site focuses on oncology, vaccines and consumer healthcare and conducts clinical research. Pfizer state that one of their missions is to increase life sciences sector investment in Finland.

Roche 94 90 Especially focused on personalized medicine, cancer treatment, arthritis, neurological illness. 30 ongoing clinical research projects in Finland. Espoo.

Santen 105 90 Santen’s European R&D centers are located in Tampere and France. Clinical research and marketing office in Helsinki. Tampere also has a production site. Focus areas are ophthalmic and anti-rheumatic pharmaceuticals.

Verman 33 55 Pharmaceutical and food supplement R&D, production and sales.

INTERESTED? WE’RE HERE TO HELP!

www.helsinkibusinesshub.fi

Marcello van Rossum

Senior Business Advisor

Health tech & life sciences

tel. +358 40 729 5583

[email protected]

INTERESTED? WE’RE HERE TO HELP!

www.helsinkibusinesshub.fi

Kimmo Koponen

Senior Business Advisor

Health tech & life sciences

tel. +358 44 757 2244

[email protected]

WE MAKE HELSINKI THE BEST PLACE TO ACCLERATE YOUR BUSINESS.


HELSINKI BUSINESS HUB RECEIVES ITS FUNDING FROM PUBLIC SOURCES – FROM THE CITIES OFHELSINKI, ESPOO, VANTAA AND KAUNIAINEN AS WELL AS THE UUSIMAA REGIONAL COUNCIL. READ MORE FROM www.helsinkibusinesshub.fi

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