HBRS - MH-Hannover: Startseite · HBRS Curriculum MD/PhD ... [email protected] ... ask at...

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Hannover Medical School Hannover Biomedical Research School HBRS HBRS HBRS HBRS Curriculum MD/PhD Program “Molecular Medicine” PhD program “Infection Biology” “Miditrain” EST Marie Curie (GBF) European Research Training group (EGRK) “Pseudomonas: Pathogenicity and Biotechnology” Research Training group (GRK 705) ”Characterization of pathophysiological animal models” Winter and Summer Semester 2005/2006

Transcript of HBRS - MH-Hannover: Startseite · HBRS Curriculum MD/PhD ... [email protected] ... ask at...

Hannover Medical School Hannover Biomedical Research School

HBRSHBRSHBRSHBRS

Curriculum

MD/PhD Program “Molecular Medicine”

PhD program “Infection Biology” “Miditrain” EST Marie Curie (GBF)

European Research Training group (EGRK) “Pseudomonas: Pathogenicity and Biotechnology”

Research Training group (GRK 705)

”Characterization of pathophysiological animal models”

Winter and Summer Semester 2005/2006

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Hannover Medical School Hannover Biomedical Research School

HBRSHBRSHBRSHBRS

Curriculum

MD/PhD Program “Molecular Medicine”

PhD program “Infection Biology” “Miditrain” EST Marie Curie (GBF)

European Research Training group (EGRK) “Pseudomonas: Pathogenicity and Biotechnology”

Research Training group (GRK 705) ”Characterization of pathophysiological animal models”

Winter and Summer Semester 2005/2006

www.mh-hannover.de/hbrs.html

http://www.gbf.de/miditrain

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PhD Curriculum Hannover Medical School

Academic Year Winter Semester 2005/2006 Start: October 17th, 2005 End: February 20th, 2006 MD/PhD “Molecular Medicine” intermediate examination: until February, 28th PhD “Infection Biology” intermediate examination: March/April 2006 Summer Semester 2006 Start: April 3rd, 2006 End: July 17th, 2006

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Dean of the HBRS and chairman of MD/PhD “Molecular Medicine”: Reinhold E. Schmidt, MD Tel.: 0049-511-532-6656 Professor of Medicine and Immunology Fax: 0049-511-532-9067 Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] ------------------------------------------------------------------------------------- Scientific Coordination of HBRS and MD/PhD “Molecular Medicine”: Dr. Susanne Kruse and Marlies Daniel HBRS Office of the MHH Tel.: 0049-511-532-6011 Präsidalamt Fax: 0046-511-532-2611 Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected], [email protected] ------------------------------------------------------------------------------------- Chairman of ZIB: Prof. Dr. Reinhold Förster Institute of Immunology Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected] Scientific Coordination of ZIB: Dr. Sabine Johann and Natalie Evans Zentrum für Infektionsbiologie - ZIB Institute of Immunology Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 D-30625 Hannover E-mail: [email protected]

http://www.mh-hannover.de/hbrs.html http://www.gbf.de/miditrain

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Members of the MD/PhD “Molecular Medicine” Commission: Prof. Dr. Reinhold E. Schmidt (Chairman) Prof. Dr. Achim Gossler (Vice Chairman) Prof. Dr. Christopher Baum Prof. Dr. Ernst-Georg Brabant Prof. Dr. Matthias Gaestel Dr. Elmar Jäckel Prof. Dr. Christoph Klein Prof. Dr. Ralf Lichtinghagen HD Dr. Beate Sodeik PD Dr. Thomas Tschernig Dr. Dorothea Gadzicki Dr. Murat Ünalan NN

Contact/coordination: Dr. Susanne Kruse and Marlies Daniel, Medizinische Hochschule Hannover, MD/PhD Office, OE 9117, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-6011; Fax. -2611; [email protected], [email protected] Members of the PhD program “Infection Biology“ and Faculty: Prof. Dr. Reinhold Förster (Chairman) Prof. Dr. Nina Baltes PD Dr. Franz-Ch. Bange Dr. Günter Bernhardt Prof. Dr. Ursula Bilitewski Prof. Dr.med. Jan Buer Dr. Dirk Bumann Prof. Singh Chatwal Dr. Kurt Dittmar Prof. Dr. Gerald-F. Gerlach Dr. Markus Gräler Dr. Mathias Gunzer Dr. Florian Gunzer Dr. Carlos Guzman Dr. Hansjörg Hauser Dr. Susanne Häußler Prof. Dr. H. Hedrich Dr. Hans Heiken Prof. Dirk Heinz Prof. Dr. Georg Herrler Dr. Christine Josenhans Prof. Dr. Andreas Klos Dr. Andreas Lengeling Prof. Dr. Edgar Maiß Prof. Dr. Dietmar Manstein Prof. Dr. Martin Messerle Prof. Dr. Volker Moennig Dr. Werner Müller Dr. Oliver Pabst Dr. Klemes Rottner Prof. Dr. von Samson-Himmeldtjerna Prof. Dr. Brigitte Schlegelberger Prof. Dr. Reinhold E. Schmidt Prof. Dr. Thomas Schnieder Prof. Dr. Thomas F. Schulz Prof. Dr. Stefan Schwarz PD Dr. Beate Sodeik Dr. Theresia Stradal Prof. Dr. Sebastian Suerbaum Prof. Dr. Ernst Ungewickell Dr. Annette Wagner Prof. Dr. Jürgen Wehland Prof. Dr. Valentin-Weigand Dr. Siegfried Weiss Dr. Dagmar Wirth

Contact/coordination: Natalie Evans, Medizinische Hochschule Hannover, Institute of Immunology, OE 5240, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-9742; Fax. -9722; [email protected] “Miditrain” EST (Marie Curie), GBF Braunschweig Prof. Dr. H. J. Hauser (chairman) Dr. Andreas Lengeling

Dr. Siegfried Weiss

Contact/coordination: Dr. Sabine Kirchhoff, GBF, Mascheroder Weg 1, 38124 Braunschweig; Tel. +49-532-6181731; Fax. -1262; [email protected] GRK 705: „Characterization of pathophysiological animal models” Prof. Dr. H. Hedrich (chairman)

Contact/coordination: PD Dr. Marie-Luise Enss, Medizinische Hochschule Hannover, Institute of Animal Sciences, OE 8600, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-3748; Fax. -3710; [email protected] European Research Training group „Pseudomonas: Pathogenicity and Biotechnology” Prof. Dr. B. Tümmler (speaker in Hannover)

Contact/coordination: Helga Riehn-Kopp, Medizinische Hochschule Hannover, Pediatric Pneumology, OE 6711, Carl-Neuberg-Str. 1, 30625 Hannover; Tel. +49-511-532-2920; Fax. -6723; [email protected]

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Content: Page Obligatory seminars for PhD programs ....................................................... 9 1st Semester (MD/PhD and PhD “Infection Biology”) ................................ 9

- in-depth seminars for medical students............................................................. 12

- in-depth seminars for life scientists ................................................................... 13 2nd Semester ........................................................................................................ 14 - second half for PhD “Infection Biology”..........................................................16 3rd Semester MD/PhD “Molecular Medicine” ............................................ 17

- Focus Immunology............................................................................................. 17

- Focus Genetics and Cell Biology ....................................................................... 20 3rd Semester PhD “Infection Biology”.......................................................... 22 4th Semester MD/PhD “Molecular Medicine” ............................................ 24

- Focus Infection................................................................................................... 24

- Focus Differentiation and Oncology ................................................................. 26 4th Semester PhD “Infection Biology” .......................................................... 28 Obligatory program for the two Research training groups (GRKs) .... 30 Optional courses............................................................................................... 32 Specific seminars ............................................................................................. 33

- organized by the HBRS ...................................................................................... 33 Requirements and Rules ................................................................................ 34 Map ....................................................................................................................... 41

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Curriculum MD/PhD “Molecular Medicine”

Curriculum PhD program “Infection biology”

For all: Seminar, 2h and Tutorial, 1h

1st year

In parallel: special in-depth seminars for medical students and students from life sciences, respectively

Basics in Molecular Medicine (Focus on Methods); Seminar, 2h

Tutorial, 1h

Tutorial for the respective seminar/tutorial series

1st sem. 2nd sem.

2nd year

1. Focus: Immunology

2. Focus: Genetics & Cell Biology

3. Focus: Infection

4. Focus: Differentiation & Oncology

or

or

4th sem. 3rd sem.

3rd year: concentration on individual research projects

Immunology/Bacteriology/ Virology

Cell Biology/ Genetics/ Biochemistry /Methods

1st year

Basics in Molecular Medicine; Seminar 2h

3rd year: concentration on individual research projects

1st sem. 2nd sem.

Immunology/Bacteriology/ Virology

Cell Biology

Project presentation (1h) and Special topic lectures in Infection Biology (1h)

2nd year

1. Focus: Immunology 3rd sem. 4th sem.

Presentation of original manuscripts and reviews

Project reports

Literature seminars and project reports; Seminar, 2h

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Structure of the PhD Program “Infection Biology“

• Sem. + Lect. Monday (16.30 - 18.00 hrs; 6 cp) • Journal Club in students own department (15 h) + attendance of 15 scientific lect. at MHH/GBF/TiHo (such as SFB- Sem. or Immunol. Colloquium; 2 cp)

• Seminar for PhD students based on reviews and original manuscripts (Monday 16.30 – 18.00) (2 cp) • Presentation of one review and one original manuscript during these seminars (2 cp)

• 3-year PhD project work (125 cp) • Three presentations in department over three years (10 cp) • Three presentations of manuscripts at the departments Journal Club over three years (3 cp) • Talk / presentation at international congress (2 cp) • Practical courses (2 x 4 days or 3 x 3 days) (12 cp) • Participation in summer schools / interdisciplinary seminars / congress (2 cp per 20h)

Intermediate exam after 18 months

PhD thesis and final exam after 3 yearscp: credit points

Year 1 Year 2 Year 3

• Sem. + Lect. In basic sciences Monday (16.30 - 18.00 hrs; 6 cp) •Tutorials Monday; till Christmas separate tutorials for edical students and life scientists (3.30 – 4.30 hrs; 2 cp) • Complex and clinical system;

choice between the foci Immunology, Infection, Oncology and Differentiation, Cell Biology/Genetics, Biochemistry Mondays, Seminar and Tutorial (3.00 – 6.00; 8 cp)

• 3-year PhD project work (125 cp) • Three presentations in department over three years (10 cp) • Three presentations of manuscripts at the departments Journal Club over three years (3 cp) • Public annual presentation/project report (10 cp) •Talk / presentation at international congress (2 cp) • Project-orientated seminars/courses; including practicals (80 h, 8 cp)

Intermediate exam after 18 months

PhD thesis and final exam after 3 yearscp: credit points

Year 1 Year 2 Year 3

Structure of the MD/PhD program “Molecular Medicine“

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Obligatory 1st Semester Joint Curriculum MD/PhD ”Molecular Medicine” and PhD “Infection Biology” Note: The curriculum of the first year is more orientated towards basics and methods in the different diciplines. MD/PhD “Molecular Medicine”: There are some alternative in-depth seminars/ tutorials on Mondays for medical students and students from life sciences till Christmas (see pages 12/13) and the respectives tutorial for the seminars. PhD “Infection Biology”: you are very welcome to attend the tutorials, but this is not a must!! For everyone!!

Welcome: General introduction, lectures, expectations etc.; answering of all questions

Achim Gossler, Susanne Kruse

Monday, 24.10.05

3.45 – 4.30 p.m.

1 hr

1.) General Immunology

Structure and components of the immune system, Janeway Chapter 1-2 Reinhold Förster

Monday, 24.10.05

4.30 – 6 p.m.

2 hrs

Recognition structures, Janeway Chapter 4,5 Robert Lindner

Monday, 31.10.05

4.30 – 6 p.m.

2 hrs

Adaptive immune responses, Janeway Chapter 9 Horst Bernhardt

Monday, 07.11.05

4.30 – 6 p.m.

2 hrs

Innate immunity, Janeway Chapter 12-13 Reinhold E. Schmidt

Monday, 14.11.05

4.30 – 6 p.m.

2 hrs

Development of the immune system Janeway Chapter (7), 8

Christoph Klein

Monday, 21.11.05

4.30 – 6 p.m.

2 hrs

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2.) General Bacteriology

Introduction to Medical Microbiology: Common themes in bacterial pathogenesis Sebastian Suerbaum

Monday 28.11.05

4.30 – 6 p.m.

2 hrs

Gram-positive pathogens (Staphylococci, Streptococci, Listeria, Clostridia etc.) Jan Buer

Monday, 05.12.04

4.30 – 6 p.m.

2 hrs

Gram-negative pathogens (Enterobacteriaceae, Helicobacter etc.) Christine Josenhans

Monday, 12.12.05 4.30 – 6 p.m.

2 hrs

Mycobacteria and Chlamydia, Mycoplasma, Spirochetes Franz C. Bange and Andreas Klos

Monday, 19.12.05

4.30 – 6 p.m.

2 hrs

Tutorial. Bacterial population genetics Sebastian Suerbaum

Monday, 09.01.06 3.30-4.15 p.m

1 hr

Diagnostic procedures in Medical Microbiology; Introduction to Antibiotics and Chemotherapy Florian Gunzer

Monday, 09.01.06

4.30 – 6 p.m.

2 hrs

Tutorial Gunzer Monday, 16.01.06 3.30-4.15 p.m

1 hr

Introduction into Medical Parasitology von Samson (TiHo)

Monday 16.01.06

4.30 – 6 p.m.

2 hrs

3.) General Virology

Tutorial von Samson: Medical Parasitology Monday, 23.01.06 3.30 – 4.15 p.m

1 hr

Overview: Virus families and viral diseases Albert Heim

Monday, 23.01.06 4.30 – 6 p.m

2 hrs

Tutorial Heim: Viruses and viral diseases Monday, 30.01.06 3.30 – 4.15 p.m

1 hr

Attachment and entry Beate Sodeik

Monday, 30.01.06 4.30 – 6 p.m

2 hrs

Tutorial Sodeik Monday, 06.02.06 3.30 – 4.15 p.m

1 hr

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RNA virus genome replication Georg Herrler

Monday, 06.02.06 4.30 – 6 p.m

2 hrs

Tutorial Herrler Monday, 13.02.06 3.30 – 4.15 p.m

1 hr

DNA virus genome replication, viral gene expression Thomas Schulz

Monday, 13.02.06 4.30 – 6 p.m

2 hrs

Tutorial Schulz Monday, 20.02.05 3.30 – 4.15 p.m

1 hr

Assembly, Egress, Maturation Gert Zimmer

Monday, 20.02.05 4.30 – 6 p.m

2 hrs

Location Hannover Biomedical Research School, MD /PhD seminar room, I 4, 2nd floor, Room 1140

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*only for MD/PhD medical students: Some more basics in Life Sciences As there are not many medical students this year, we will arrange an individual program for you! Or you visit the tutorials for life scientists or PhD “Infection Biology” Mondays, 3.30 – 4.30 p.m. [Microbiology, Developmental Biology (Kispert), Biochemistry (Kotlyarov), Virology (Verhagen), Genetics (Schubert)] Location Hannover Biomedical Research School, I 4, 2nd floor, ask at MD/PhD office

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** only for MD/PhD students from life sciences: some basics in Medicine/Techniques Welcome: see above Monday, 24.10.05

3.45 – 4.30 p.m.

1 hr

Immunodynamics

Matthias Gunzer

Monday, 31.10.05

3.30 – 4.30 p.m.

1 hr

Stem cell directed gene transfer /gene therapy

Peter Horn

Monday, 07.11.05

3.30 –4.30 p.m.

1 hr

Gene therapy, hematological diseases

Li (Dept. Baum)

Monday, 14.11.05

3.30 – 4.30 p.m.

1 hr

Clinal Immunology I: pathogenesis of an autoimmune disease (Lupus erythematosus)

Torsten Witte

Monday 21.11.05

3.30 – 4.30 p.m.

1 hr

Clinical Immunology II: pathogenesis of HIV infection and immunological consequences

Hans Heiken

Monday, 28.11.05

3.30 – 4.30 p.m.

1 hr

Hematology: pathogenesis of an hematological disease

Matthias Eder

Monday, 05.12.05

3.30 – 4.30 p.m.

1 hr

Oncology: Aging

Lenhard Rudolph

Monday, 12.12.05

3.30 – 4.30 p.m.

1 hr

FACS analysis

Roland Jacobs

Monday, 19.12.05

3.30 – 4.30 p.m.

1 hr

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2nd Semester

Joint Curriculum MD/PhD and PhD Infection Biology MD/PhD: please attend the whole of the seminars and tutorials listed below. Note, there is a change of time after the Cell Biology part!! PhD Infection Biology: You should attend the seminars up to May 15th (including the Cell Biology), you are very welcome to attend the tutorials, but this is not a must!! Afterwards you have your own seminars (see page )

Tutorial Zimmer Monday 03.04.06 3.30 – 4.15 p.m.

2 hrs

Viral pathogenesis Martin Messerle

Monday 03.04.06 4.30 – 6 p.m. 2 hrs

4. ) General Cell Biology

Tutorial Messerle Monday, 10.04.06 3.30 – 4.15 p.m

1 hr

Cell Biology I: GTPases Stradal

Monday 10.04.06 4.30 – 6 p.m. 2 hrs

No seminars, public holidays Monday 17.04.06 - -

Tutorial Stradal Monday, 24.04.06 3.30 – 4.15 p.m

1 hr

Cell Biology II: Microtubules Jürgen Wehland

Monday, 24.04.06 4.30 – 6 p.m 2 hrs

No seminars, public holidays Monday 01.05.06 - -

Tutorial Wehland Monday, 08.05.06 3.30 – 4.15 1 hr

Cell Biology III: Cell cycle Hans J. Hauser

Monday, 08.05.06 4.30 – 6 p.m 2 hrs

Now only for MD/PhD!!

5.) Biochemistry and Genetics; methods

Human gene finding; basics of human genes (intro in general genetics, mapping: mouse, human) M. Stuhrmann Spangenberg

Monday, 15.05.06 3 – 5 p.m 2 hrs

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Tutorial Monday, 15.05.06 5 – 6 p.m 1 hr

NN Monday, 22.05.06 3 – 5 p.m 2 hrs

Tutorial Stuhrmann-Spangenberg Monday, 22.05.06 5 – 6 p.m 1 hr

Strategies to analyse gene function in vivo Achim Gossler

Monday 29.05.06 3 – 5 p.m. 2 hrs

Tutorial NN Monday 29.05.06 5 – 6 p.m 1 hr

No seminars, public holidays Monday 05.06.06 - -

Global gene and protein expression profilingBrigitte Schlegelberger

Monday, 12.06.06 3 – 5 p.m 2 hrs

Tutorial Gossler Monday, 12.06.06 5 – 6 p.m 1 hr

MAP-kinases

Alexey Kotlyarov

Monday, 19.06.06 3 – 5 p.m 2 hrs

Tutorial Schlegelberger Monday, 19.06.06 5 – 6 p.m 1 hr

Protein & membrane trafficking (exocytosis, membrane fusion, organell biosynthesis)

Ernst Ungewickell

Monday, 26.06.06 3 – 5 p.m 2 hrs

Tutorial Kotlyarov Monday, 26.06.06 5 – 6 p.m 1 hr

Proteomics applied to clinical research and diagnostics

Eva Mischak-Weissinger

Monday, 03.07.06 3 – 5 p.m 2 hrs

Tutorial Ungewickell Monday, 03.07.06 5 – 6 p.m 1 hr

Spectroscopy, hydrodynamics, structure, imaging

Claus Urbanke

Monday, 10.07.06 3 – 5 p.m 2 hrs

Tutorial Mischak-Weissinger Monday, 10.07.06 5 – 6 p.m 1 hr

Tutorial Urbanke Monday, 17.07.05 5 – 6 p.m 1 hr

Location Hannover Biomedical Research School, I 4, 2nd floor, Room 1140 (MD/PhD seminar room) For all MD/PhD students: A block course of 1 week in Bioinformatics is planned.

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2nd Semester

PhD Infection Biology Time: 4.30 – 6 p.m.

08.05.2006 Project Presentation 1 Project Presentation 2 Topic Focus I 15.05.2006 Project Presentation 3

Project Presentation 4 Topic Focus II 22.05.2006 Project Presentation 5

Project Presentation 6 Topic Focus III 29.05.2006 Project Presentation 7

Project Presentation 8 Topic Focus IV 06.06.2006 Project Presentation 9

Project Presentation 10 Topic Focus V 12.06.2006 Project Presentation 11

Project Presentation 12 Topic Focus VI 19.06.2006 Project Presentation 13

Project Presentation 14 Topic Focus VII 26.06.2006 Project Presentation 15

Project Presentation 16 Topic Focus VIII 03.07.2006 Project Presentation 17

Project Presentation 18 Topic Focus IX 10.07.2006 Project Presentation 19

Project Presentation 20 Topic Focus X

Location Department of Microbiology, building I6, level 5, seminar room

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3rd Semester

MD/PhD program “Molecular Medicine” Note: The curriculum of the second year is more orientated towards research and applied aspects in the different diciplines. Every student has the choice between two major foci each semester. You may vary in the choice of modules between the two foci. Please, choose the ones most appropriate for you and your project! 1. Focus: Immunology

1. Immune cells and organs

T and B cell differentiation Fritz Melchers (Berlin/Basel) and tutorial 5-6 p.m.

Monday 24.10.05 3 – 5 p.m. 2 hrs

Tutorial Melchers

Functional organization in lymphoid organs Reinhold Förster

Monday, 31.10.05 3 – 5 p.m 2 hrs

Tutorial Förster Monday, 31.10.05 5 – 6 p.m 1 hr

Differentiation of dendritic cells and macrophages

Christoph Klein

Monday, 07.11.05 3 – 5 p.m 2 hrs

No tutorial Monday, 07.11.05 5 – 6 p.m 1 hr

Regulation and function of NK cells Roland Jacobs

Monday, 14.11.05 3 – 5 p.m 2 hrs

Tutorial C. Klein Monday, 14.11.05 5 – 6 p.m 1 hr

2. Autoimmunity

Autoimmunity, tolerance, negative selection Elmar Jäckel

Monday 21.11.05 3 – 5 p.m. 2 hrs

Tutorial Jacobs Monday 21.11.05 5 – 6 p.m 1 hr

The complement system – the regulation of anaphylatoxin receptors Andreas Klos

Monday, 28.11.05 3 – 5 p.m 2 hrs

Tutorial Jaeckel Monday, 28.11.05 5 – 6 p.m 1 hr

Fc-mediated mechanisms in autoimmune disease Engelbert J. Gessner

Monday, 05.12.05 3 – 5 p.m 2 hrs

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Tutorial Klos Monday, 05.12.05 5 – 6 p.m 1 hr

3. Allergy and Asthma

Mechanisms in allergic inflammation (asthma) Norbert Krug (Fraunhofer Institute)

Monday 12.12.05 3 – 5 p.m. 2 hrs

Tutorial Gessner Monday 12.12.05 5 – 6 p.m 1 hr

Neuroimmune interactions in asthma bronchiale Armin Braun (Fraunhofer Institute)

Monday, 19.12.05 3 – 5 p.m 2 hrs

Tutorial Krug Monday, 19.12.05 5 – 6 p.m 1 hr

Immunobiology of eczematous skin disease Miriam Wittmann

Monday, 09.01.06 3 – 5 p.m 2 hrs

Tutorial Braun Monday, 09.01.06 5 – 6 p.m 1 hr

4. Innate Immunity

Innate immunity (Toll-like receptors) Hansjörg Hauser (GBF)

Monday 16.01.06 3 – 5 p.m. 2 hrs

Tutorial Wittmann Monday 16.01.06 5 – 6 p.m 1 hr

Immune response in HIV Reinhold E. Schmidt

Monday, 23.01.06 3 – 5 p.m 2 hrs

Tutorial Hauser Monday, 23.01.06 5 – 6 p.m 1 hr

Transfer of DNA through bacteria Siegfried Weiss (GBF)

Monday, 30.01.06 3 – 5 p.m 2 hrs

Tutorial Schmidt Monday, 30.01.06 5 – 6 p.m 1 hr

5. Signaling and therapy

Post transcriptional gene regulation Helmut Holtmann

Monday 06.02.06 3 – 5 p.m. 2 hrs

Tutorial Weiss Monday 06.02.06 5 – 6 p.m 1 hr

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Regulation of immune responses by CD45 molecules Reinhard Schwinzer

Monday, 13.02.06 3 – 5 p.m 2 hrs

Tutorial Holtmann Monday, 13.02.06 5 – 6 p.m 1 hr

Major Histocompatibility complex as key for adoptive immunotherapy R. Blasczyk und B. Elz-Vesper

Monday, 20.02.06 3 – 5 p.m 2 hrs

Tutorial Schwinzer Monday, 20.02.06 5 – 6 p.m 1 hr

Tutorial Blasczyk Monday, 27.02.06 5 – 6 p.m 1 hr

Location Building I4, level SO (ground floor), seminar room (right to the main entrance)

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2. Focus: Genetics and Cell Biology

1. Techniques and diagnostics/therapy

Structure and function of erythrocyte membrane proteins A. Seltsam

Monday 24.10.05 3 – 5 p.m. 2 hrs

No tutorial

A rationale approach to quantitative PCR and chip techniques exemplified in diagnosis of transplant rejection Jürgen Strehlau

Monday, 31.10.05 3 – 5 p.m 2 hrs

Tutorial Seltsam Monday, 31.10.05 5 – 6 p.m 1 hr

Engineering and design of enzymes Jürgen Alves

Monday, 07.11.05 3 – 5 p.m 2 hrs

Tutorial Strehlau Date to be annouced

Embryonic and somatic cloning in mammals Heiner Niemann (Mariensee)

Monday, 14.11.05 3 – 5 p.m 2 hrs

Tutorial Alves Monday, 14.11.05 5 – 6 p.m 1 hr

2. Genetics

The genetics of Morfan syndrome and related disorders Jörg Schmidtke

Monday 21.11.05 3 – 5 p.m. 2 hrs

Tutorial Niemann Monday 21.11.05 5 – 6 p.m 1 hr

The dissection of the endocytic machinery by RNAi Ernst Ungewickell

Monday, 28.11.05 3 – 5 p.m 2 hrs

Tutorial Arslan (group Schmidtke) Monday, 28.11.05 5 – 6 p.m 1 hr

Molecular biology of heart failure Denise Hilfiker

Monday, 05.12.05 3 – 5 p.m 2 hrs

Tutorial Ungewickell Monday, 05.12.05 5 –6 p.m 2 hr

3. Transmembrane Signaling

Antigen processing, MHC II trafficking and the lipid environment Robert Lindner

Monday 12.12.05 3 – 5 p.m. 2 hrs

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Tutorial Hilfiker Monday 12.12.05 5 – 6 p.m 1 hr

Stress-dependent signal transduction in eukaryotic cells Matthias Gaestel

Monday, 19.12.05 3 – 5 p.m 2 hrs

Tutorial Lindner Monday, 19.12.05 5 – 6 p.m 1 hr

Small GTPases as targets of bacterial toxins Harald Genth (group I. Just)

Monday, 09.01.06 3 – 5 p.m 2 hrs

Tutorial Gaestel Monday, 09.01.06 5 – 6 p.m 1 hr

How molecular motors work Dietmar Manstein

Monday 16.01.06 3 – 5 p.m. 2 hrs

Tutorial Genth Monday 16.01.06 5 – 6 p.m 1 hr

4. Cell Biology and disease

Pathophysiology of arterioclerosis Bernhard Schieffer

Monday, 23.01.06 3 – 5 p.m 2 hrs

Tutorial Manstein Monday, 23.01.06 5 – 6 p.m 1 hr

Congenital disorders of glycosylation Francoise Routier

Monday, 30.01.06 3 – 5 p.m 2 hrs

Tutorial Schieffer Monday, 30.01.06 5 – 6 p.m 1 hr

Cancer and genes Brigitte Schlegelberger

Monday 06.02.06 3 – 5 p.m. 2 hrs

Tutorial Routier Monday 06.02.06 5 – 6 p.m 1 hr

Molecular mechanisms of diabetic nephropathy Hermann Haller

Monday, 13.02.06 3 – 5 p.m 2 hrs

Tutorial Schlegelberger Monday, 13.02.06 5 – 6 p.m 1 hr

5. Side aspects

Molecular epidemiology Olaf Dammann

Monday, 20.02.06 3 – 5 p.m 2 hrs

Tutorial Haller (stem cells in renal injury) Monday, 20.02.06 5 – 6 p.m 1 hr

Tutorial Dammann Monday, 27.02.06 5 – 6 p.m 1 hr

Location TPFZ, Research building, ground floor, seminar room 1420 II

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Priy

anka

Nar

ang

Hog

quis

t: C

entra

l tol

eran

ce: L

earn

ing

self-

cont

rol i

n th

e th

ymus

07.1

1.20

05

Orig

inal

Pap

er IM

M

ülle

r (IM

) N

icol

as F

asna

cht

Kiss

enpf

enni

g: D

ynam

ics

and

func

tion

of L

ange

rhan

s ce

lls in

viv

o

Rev

iew

IM

Be

ata

Zygm

unt

Liew

: Neg

ativ

e re

gula

tion

of to

ll-lik

e re

cept

or-m

edia

ted

imm

une

resp

onse

s

14.1

1.20

05

Orig

inal

Pap

er IM

W

irth

(IM)

Upn

eet S

andh

u Lu

: Lip

opol

ysac

char

ide

deac

ylat

ion

by a

n en

doge

nous

lipa

se c

ontro

ls G

ram

-neg

ativ

e ba

cter

ia

R

evie

w IM

Kers

tin R

adtk

e M

ills: R

egul

ator

y T

cells

: Frie

nd o

r foe

in im

mun

ity to

infe

ctio

n?

21.1

1.20

05

Orig

inal

Pap

er IM

G

räle

r (IM

) Sv

en-C

hr

Sens

ken

Wal

ther

: Upr

egul

atio

n of

TG

F-β

…pa

rasi

te g

row

th in

hum

an m

alar

ia in

fect

ion

R

evie

w IM

Dav

ide

Ferra

ris

Ran

dolp

h: D

endr

itic-

cell

traffi

ckin

g to

lym

ph n

odes

thro

ugh

lym

phat

ic v

esse

ls

28.1

1.20

05

Orig

inal

Pap

er IM

rste

r (IM

) Ja

net K

rege

W

ang:

CD

19

regu

late

s B

cell

mat

urat

ion…

in th

e FD

C z

one

of m

urin

e sp

leni

c ge

rmin

al

cent

ers

R

evie

w IM

Dor

othe

a Sc

hmid

t R

eher

man

n: Im

mun

olog

y of

Hep

atiti

s B

Viru

s an

d H

epat

itis

C V

irus

infe

ctio

n

05.1

2.20

05

Orig

inal

Pap

er IM

G

unze

r M. (

IM)

Pete

r Rei

char

dt

Wat

kins

: Fun

ctio

nal c

onne

ctiv

ity b

etw

een

imm

une

cells

med

iate

d by

tunn

elin

g na

notu

bule

s

Rev

iew

IM

C

arol

ine

Zaou

i Sa

lmi:

Cel

l-sur

face

enz

ymes

in c

ontro

l of l

euko

cyte

traf

ficki

ng

12.1

2.20

05

Orig

inal

Pap

er

MB

Chh

atw

al (M

B)

Vane

ssa

Barro

so

Ram

amoo

rti: T

he L

yme

dise

ase

agen

t exp

loits

a ti

ck p

rote

in to

infe

ct th

e m

amm

alia

n ho

st

23

R

evie

w M

B

Step

hani

e W

eiß

Akto

ries:

Bac

teria

l cyt

otox

ins:

targ

etin

g eu

kary

otic

sw

itche

s

19.1

2.20

05

Orig

inal

Pap

er

MB

Bang

e (M

B)

Priy

anka

Nar

ang

Andr

ies:

A d

iary

lqui

nolin

e dr

ug a

ctiv

e on

the

ATP

synt

hase

of M

ycob

acte

rium

tube

rcul

osis

Rev

iew

MB

Pe

ter R

eich

ardt

M

erre

ll: F

ront

al a

nd s

teal

th a

ttack

stra

tegi

es in

mic

robi

al p

atho

gene

sis

09.0

1.20

06

Orig

inal

Pap

er

MB

Suer

baum

(M

B)

Mai

ke d

e Bu

hr

Gre

ssm

ann:

Gai

n an

d lo

ss o

f mul

tiple

gen

es in

Hel

icob

acte

r pyl

ori

R

evie

w M

B

Nic

olas

Fas

nach

t Th

omas

: Mec

hani

sms

of, a

nd b

arrie

rs to

, hor

izon

tal g

ene

trans

fer b

etw

een

bact

eria

16.0

1.20

06

Orig

inal

Pap

er

MB

Ger

lach

(MB)

Ju

lia H

einz

man

n O

gaw

a: E

scap

e of

intra

cellu

lar S

hige

lla fr

om a

utop

hagy

Rev

iew

MB

Ja

net K

rege

D

obrin

dt: G

enom

ic is

land

s in

pat

hoge

nic

and

envi

ronm

enta

l mic

roor

gani

sms.

23.0

1.20

06

Orig

inal

Pap

er

MB

Klos

(MB)

Ka

y Jo

hsw

ich

Bade

r: R

ecog

nitio

n of

ant

imic

robi

al p

eptid

es b

y a

bact

eria

l sen

sor k

inas

e

Rev

iew

MB

U

pnee

t San

dhu

Mot

a: T

he b

acte

rial i

njec

tion

kit:

type

III s

ecre

tion

syst

ems

30.0

1.20

06

Orig

inal

Pap

er

MB

Gun

zer F

. (M

B)

Dor

othe

a Sc

hmid

t Vo

lkm

an: T

uber

culo

us g

ranu

lom

a fo

rmat

ion

is e

nhan

ced

by a

myc

obac

teriu

m v

irule

nce

::

Rev

iew

MB

N

uno

Vieg

as

Back

hed:

Hos

t-bac

teria

l mut

ualis

m in

the

hum

an in

test

ine.

06.0

2.20

06

Orig

inal

Pap

er

MB

Jose

nhan

s (M

B)

Dav

ide

Ferra

ris

Mar

keto

n: P

lagu

e ba

cter

ia ta

rget

imm

une

cells

dur

ing

infe

ctio

n

Rev

iew

MB

Ju

lia P

ulve

rer

Boye

r L: T

arge

ting

of h

ost-c

ell u

biqu

itin

and

ubiq

uitin

-like

pat

hway

s by

bac

teria

l fac

tors

13.0

2.20

06

Orig

inal

Pap

er

VIR

So

deik

(VIR

) Ke

rstin

Rad

tke

Pelk

man

s: K

inas

es a

. vira

l end

ocyt

osis

Rev

iew

VIR

Julia

Hei

nzm

ann

Smith

: How

viru

ses

ente

r cel

ls

20.0

2.20

06

Orig

inal

Pap

er

VIR

G

uzm

an (V

IR)

Beat

a Zy

gmun

t Va

ccin

e de

velo

pmen

t

Rev

iew

VIR

Kay

Johs

wic

h Va

ccin

e de

velo

pmen

t L

ocat

ion:

TPF

Z, R

esea

rch

build

ing,

gro

und

floor

, sem

inar

roo

m 1

420

I (or

sem

inar

roo

m V

irol

ogy,

I6, l

evel

6)

4th Semester

MD/PhD program “Molecular Medicine”

3. Focus: Infection

1. Viruses and disease

From Virus pathogenesis to viral therapies Christopher Baum

Monday 03.04.06 3 – 5 p.m. 2 hrs

No tutorial

The role of the host cytoskeleton during Herpes simplex virus infection Beate Sodeik

Monday, 10.04.06 3 – 5 p.m 2 hrs

Tutorial Baum Monday, 10.04.06 5 – 6 p.m 1 hr

No seminars, public holidays Monday 17.04.06

Viral hepatitis: from immunopathogenesis to immunotherapy Heiner Wedemeyer

Monday, 24.04.06 3 – 5 p.m 2 hrs

Tutorial Sodeik Monday, 24.04.06 5 – 6 p.m 1 hr

No seminars, public holidays Monday 01.05.06

2. Bacteria and disease

Helicobacter pylori infection Sebastian Suerbaum

Monday 08.05.06 3 – 5 p.m. 2 hrs

Tutorial Wedemeyer Monday 08.05.06 5 – 6 p.m 1 hr

The role of the metabolism in the pathogenesis of tuberculosis Franz-C. Bange

Monday, 15.05.06 3 – 5 p.m 2 hrs

Tutorial Suerbaum Monday, 15.05.06 5 – 6 p.m 1 hr

Pathogenicity of EHEC disease Florian Gunzer

Monday, 22.05.06 3 – 5 p.m 2 hrs

Tutorial Bange Monday, 22.05.06 5 – 6 p.m 1 hr

3. Genetics and disease

Medical genomics Jan Buer

Monday 29.05.06 3 – 5 p.m. 2 hrs

25

Tutorial Gunzer Monday 29.05.06 5 – 6 p.m 1 hr

No seminars, public holidays Monday 05.06.06

Genetic susceptibility to infectious disease Burkhard Tümmler

Monday, 12.06.06 3 – 5 p.m 2 hrs

Tutorial Buer Monday, 12.06.06 5 – 6 p.m 1 hr

Functional and comparative genomics of infectious diseases Andreas Lengeling (GBF)

Monday, 19.06.06 3 – 5 p.m 2 hrs

Tutorial Tümmler Monday, 19.06.06 5 – 6 p.m 1 hr

4. Infection and immune system

Host-pathogen interactions Jürgen Wehland (GBF)

Monday 26.06.06 3 – 5 p.m. 2 hrs

Tutorial Lengeling Monday 26.06.06 5 – 6 p.m 1 hr

The Mycoplasma-derived lipopeptide MALP-2 is a promising adjuvant for the development of mucosal vaccines against HIV/AIDS Carlos Guzman (GBF)

Monday, 03.07.06 3 – 5 p.m 2 hrs

Tutorial Wehland Monday, 03.07.06 5 – 6 p.m 1 hr

Can we cure AIDS? Christopher Baum

Monday, 10.07.06 3 – 5 p.m 2 hrs

Tutorial Guzman Monday, 10.07.06 5 – 6 p.m 1 hr

Tutorial Baum Monday, 17.07.06 5 – 6 p.m 1 hr

Location Building I4, level SO (ground floor), seminar room (right to the main entrance)

26

4. Focus: Differentiation and Oncology

1. Development and cancer

[Achim Gossler] Monday 03.04.06 3 – 5 p.m. 2 hrs

No tutorial

T-box genes in development and disease Andreas Kispert

Monday, 10.04.06 3 – 5 p.m 2 hrs

Tutorial Monday, 10.04.06 5 – 6 p.m 1 hr

No seminars, public holidays Monday 17.04.06

From fly to cancer Nils v. Neuhoff

Monday, 24.04.06 3 – 5 p.m 2 hrs

Tutorial Kispert Monday, 24.04.06 5 – 6 p.m 1 hr

No seminars, public holidays Monday 01.05.06

Epigenetics in cancer Ulrich Lehmann

Monday 08.05.06 3 – 5 p.m. 2 hrs

Tutorial v. Neuhoff Monday 08.05.06 5 – 6 p.m 1 hr

2. Stem cells and cancer

Tumor stem cells Hans-H. Kreipe (seminar room Pathology!!)

Monday, 15.05.06 3 – 5 p.m 2 hrs

Tutorial Lehmann Monday, 15.05.06 5 – 6 p.m 1 hr

Inborn errors in hematopoiesis Karl Welte

Monday, 22.05.06 3 – 5 p.m 2 hrs

Tutorial Kreipe Monday, 22.05.06 5 – 6 p.m 1 hr

Organogenesis and stem cell differentiation of the liver Michael Ott

Monday 29.05.06 3 – 5 p.m. 2 hrs

Tutorial Welte Monday 29.05.06 5 – 6 p.m 1 hr

No seminars, public holidays Monday 05.06.06

Embryonic and adult stem cells: strategies for pancreatic and hepatic differentiation Anna Wobus (Gatersleben)

Monday, 12.06.06 3 – 5 p.m 2 hrs

27

Tutorial Wobus Monday, 12.06.06 5 – 6 p.m 1 hr

3. Signaling and cancer

Cytokine-receptor signaling, oncogenes and myeloproliferation Matthias Eder

Monday, 19.06.06 3 – 5 p.m 2 hrs

Tutorial Ott Monday, 19.06.06 5 – 6 p.m 1 hr

RNAi-based target validation in hematopoietic cells Michaela Scherr

Monday 26.06.06 3 – 5 p.m. 2 hrs

Tutorial Eder Monday 26.06.06 5 – 6 p.m 1 hr

The role of telomere shortening and telomerase in aging, regeneration and cancer Lenhard Rudolph

Monday, 03.07.06 3 – 5 p.m 2 hrs

Tutorial Scherr Monday, 03.07.06 5 – 6 p.m 1 hr

Regulation of cell cycle progression and tumor development by the cyclin kinase inhibitor/tumor suppressor protein p27 Nisar Malek

Monday, 10.07.06 3 – 5 p.m 2 hrs

Tutorial Rudolph Monday, 10.07.06 5 – 6 p.m 1 hr

Tutorial Malek Monday, 17.07.06 5 – 6 p.m 1 hr

Location to be announced

4th S

emes

ter

PhD

pro

gram

“In

fect

ion

Bio

logy

Tim

e: 4

.30

– 6

p.m

.

DA

TE

FOC

US

SUPE

RVI

SOR

STU

DEN

T SU

BJE

CT

03

.04.

2006

O

rigin

al P

aper

CB

Hau

ser (

CB)

Ju

lia P

ulve

rer

TBA

R

evie

w C

B

Hei

ke d

e Bu

hr

Barb

acid

: To

cycl

e or

not

to c

ycle

: A c

ritic

al d

ecis

ion

in c

ance

r

10.0

4.20

06

Orig

inal

Pap

er C

B W

ehla

nd (C

B)

Car

olin

e Za

oui

Ree

ves:

Dis

ablin

g po

xviru

s pa

thog

enes

is b

y in

hibi

tion

of A

bl-fa

mily

tyro

sine

ki

nase

s

R

evie

w C

B

Sven

-Chr

. Se

nske

n G

alja

rt: C

lips

and

clap

s an

d ce

llula

r dyn

amic

s

24.0

4.20

06

Orig

inal

Pap

er C

B St

rada

l (C

B)

Step

hani

e W

eiß

Yang

: Mam

mal

ian

CAR

MIL

inhi

bits

acr

in fi

lam

ent c

appi

ng b

y ca

ppin

g pr

otei

n

R

evie

w C

B

Mar

cin

Lysz

kiew

icz

Ros

sman

n: G

ef m

eans

go:

Tur

ning

on

RH

O G

TPas

es w

ith g

uani

ne n

ucle

otid

e..

02.0

5.20

06

Proj

ect P

rese

ntat

ion

I W

eiss

(IM

) M

arci

n Ly

szki

ewic

z to

be

fille

d in

by

ZIB

Sek

reta

riat

Pr

ojec

t Pre

sent

atio

n II

Wei

ss (I

M)

Nun

o Vi

egas

08.0

5.20

06

Proj

ect P

rese

ntat

ion

I M

ülle

r (IM

) N

icol

as F

asna

cht

Pr

ojec

t Pre

sent

atio

n II

Wirt

h (IM

) U

pnee

t San

dhu

15.0

5.20

06

Proj

ect P

rese

ntat

ion

I G

räle

r (IM

) Sv

en-C

hr.

Sens

ken

Pr

ojec

t Pre

sent

atio

n II

Förs

ter (

IM)

Jane

t Kre

ge

29

22.0

5.20

06

Proj

ect P

rese

ntat

ion

I G

unze

r M. (

IM)

Pete

r Rei

char

dt

Pr

ojec

t Pre

sent

atio

n II

Gun

zer M

. (M

B)

Priy

anka

Nar

ang

29.0

6.20

06

Proj

ect P

rese

ntat

ion

I C

hhat

wal

(MB)

Va

ness

a Ba

rroso

Pr

ojec

t Pre

sent

atio

n II

Hei

nz (M

B)

Dav

ide

Ferra

ris

06.0

6.20

06

Proj

ect P

rese

ntat

ion

I G

erla

ch (M

B)

Julia

Hei

nzm

ann

Pr

ojec

t Pre

sent

atio

n II

Klos

(MB)

Ka

y Jo

hsw

ich

12.0

6.20

06

Proj

ect P

rese

ntat

ion

I G

unze

r F.

(MB)

D

orot

hea

Schm

idt

Pr

ojec

t Pre

sent

atio

n II

Hed

rich

(MB)

M

aike

de

Buhr

19.0

6.20

06

Proj

ect P

rese

ntat

ion

I So

deik

(VIR

) Ke

rstin

Rad

tke

Pr

ojec

t Pre

sent

atio

n II

Guz

man

(VIR

) Be

ata

Zygm

unt

26.0

6.20

06

Proj

ect P

rese

ntat

ion

I H

ause

r (C

B)

Julia

Pul

vere

r

Pr

ojec

t Pre

sent

atio

n II

Weh

land

(CB)

C

arol

ine

Zaou

i

03.0

7.20

06

Proj

ect P

rese

ntat

ion

I St

rada

l (C

B)

Step

hani

e W

eiß

10.0

7.20

06

TBA

Loc

atio

n:

Sem

inar

roo

m D

ept.

of V

irol

ogy,

Bui

ldin

g I6

, lev

el 6

European research training group “Pseudomonas”: 1. Colloquium 'Pseudomonas: Pathogenicity and Biotechnology', monthly, Thursdays 18.00 - 19.45; Lecture Hall G

2. Course: Introduction into phylogenomics and microbial genome linguistics 1- to 2 full days; enquiries: Mrs Riehn-Kopp, [email protected] Research training group, GRK 705: Characterization of pathophysiological animal models” 1. Lectures given by the supervisors

Mondays, 4.15 p.m., lecture room, Institute for Laboratory Animal Sciences, MHH Date speaker, institute title

31.10.2005 Prof. Achim Gossler Institute for Molecular Biology, MHH

Transgenic techniques in mice

14.11.2005 Dr. Armin Braun, Fraunhofer Institute, Hannover

GLP and good scientific practice

05.12.2005 Prof. Hans J. Hedrich Institute for Laboratory Animal Sciences, MHH

Model development and control, model definition, characteristics and selection

09.01.2006 Prof. Stephan Steinlechner Zoology, TiHo

Chronobiology

06.02.2006 Dr. Dirk Wedekind Institute for Laboratory Animal Sciences, MHH

Linkage analysis and identification of genes

2. Seminars by invited speakers

Thursdays, 5.15 p.m., lecture room,Central Facility for Laboratory Animals, MHH Date speaker, institute title 13.10.2005 Joachim Wittbroth, PhD EMBL,

Heidelberg Control of proliferation and differentiation in the developing retina

17.11.2005 Dr. Craig P. Smith Schoolof Biological Sciences University of Manchester, UK

Urea transporters: what, when and why?

15.12.2005 Prof. Heinfried Radeke, Pharmazentrum Frankfurt, Johann Wolfgang Goethe Universität Frankfurt

Defining new targets for the treatment of inflammatory diseases: pathological homing and regulatory dendritic cells

19.01.2006 NN NN Special lecture Seminar room, Max Planck Institute, 5 p.m.

06.09.2005

Prof. Raphael Kopan Washington University, St. Louis, USA

Presenilin links Notch and Wnt clocks in the somite

31

3. GK Meetings Thursdays, 4.15 p.m., seminar room, Central Facility for Laboratory Animals 4. “Soft skills”

Date Speaker 24.11.2005 Prof. Gerhard Breves

Institute of Physiology University of Veterinary Medicine Hannover (TiHo)

The successful proposal

01.12.2005 Dr. Angelika Langsch Institute of Food Toxicology, University of Veterinary Medicine Hannover (TiHo)

Alternatives to animal models

16.02.2006 Research students and fellows Violetta Pilorz, Barbara Fuchs and Tanja Arndt

Congress experience

12.–13.01.06 Workshop Projectmanagement, Bergkirchen

5. Pratical courses

Supervisor/location topic participant Andree Bleich, PhD Institute for Laboratory Animal Science, MHH

Micobiological control of laboratory animals

2

Prof. Johannes Gessner Clinical Immunology, MHH

Cellular immunology 6

Prof. Achim Gossler Molecular Biology, MHH

Techniques in molecular genetics 3

Prof. Stephan von Hörsten Anatomy, MHH

Characterization of behaviour

3

Dr. Dirk Wedekind Institute for Laboratory Animal Science, MHH Dr. Matthias Elsner Clinical Biochemistry

Analysis of sequence and genome 3

32

German Classes Wednesdays: 7 p.m. – 8.30 p.m. (beginners); 5.30 p.m. -7 p.m. (advanced); teacher: Mrs Marotz, MD/PhD seminar room

Optional (According to the MHH-Curriculum; see board next to the student’s secretary office) Note: You are welcome to visit most of the seminars/courses organized for the German Biology and Biochemistry students, as well as medical students. You are also welcome to visit seminars/courses offered by all programmes of the HBRS (including the Graduate School of the Veterinary School).

Specific seminars (see special announcements provided by the HBRS office and the respective departments)

Experimental Techniques

- Workshops of the Graduiertenkollegs

- Classical and molecular tumor cytogenetics

- Quantitative analysis of protein and peptid interactions

- Immunological methods in cell biology

- Introduction into molecular pathology

- Fluorescence-in-situ-hybridization (FISH) in the diagnostics of hematologic diseases

- Confocal microscopy

Special Seminars

- Molecular aspects of the hepato- und gastroenterology

- Moleculargenetic diagnostics of inheritable diseases

- Aspects of molecular medicine

- Genexpression and growth control

- Laser in biology, medicine and environmental research

- Quantitative biology: biophysical examples from medicine and biology

- Molecular genetics

- Molecular genetics of development

Radiation protection

33

Organized by the HBRS Office:

Presentation of projects (weekend, 2 days; for MD/PhD: March/April, 2006)

Gene Technology Security (September, 2006)

Introduction to Ethics (weekend workshop; Schmidtke) - Medical Ethics - Ethical aspects of gene technology - Science ethics - Good laboratory practise

Research Ethics (2-day workshop; February/March 2006)

Presentation seminar (2 days, July 2006, Dierks)

Workshop with practical lessons for optimal presentation (lecturers, rhetorical etc.)

Scientific communication/ writing (January 2006, Kruse)

Animal Experiments (November21st-23rd, 2005, Hedrich)

Intercultural communication (2 days, April 2006) Seminars offered by the GBF, Fraunhofer Institute or TiHo: see announcements

Lectures (see special announcements and websites)

Interdisciplinary

- Seminars of the Graduiertenkollegs (including the European Graduate College) - Seminars of the SFBs - Seminars of the PhD program “Infection Biology” - Immunological Kolloquium - Biochemical Kolloquium - Gastroenterology Kolloqium - Microbiological Kolloquium - Kolloquia at GBF - Seminars and Kolloquia at TiHo - Biological and Biochemical Questions (BBQ)

In the departments (a must!!)

- Doktorandenseminare (MD/PhD seminars)

- Journal-Clubs (these should be in English!)

Internal practical courses

The supervisors provide you with special practical trainings if needed.

http://www.mh-hannover.de/hbrs.html http://www.gbf.de/miditrain

34

Requirements and Rules for Postgraduate Studies and Examinations to Obtain a PhD Degree at the Hannover Medical School

On 15 December 2000 the Senate of the Medical School of Hannover resolved the following Requirements and Rules for Postgraduate Studies and Examinations to Obtain a PhD Degree at the Medical School of Hanover (alternatively Dr. rer. nat. for life scientists). (additions on June 4th 2002, February 11th 2004)

Chapter One

Objective of PhD Studies

§ 1 Objective Research studies at the Hannover Medical School (MHH) for the purpose of obtaining a PhD degree (hereinafter referred to as PhD studies) shall facilitate postgraduate training with a focus on specific research projects with a view to enabling the candidate to do in-depth scientific work on his or her own and to provide him or her with additional professional qualifications for future assignments in research or related areas of work. PhD studies shall foster the development of outstandingly gifted up-and-coming academics. The standard time allowed for completing PhD studies shall be three years. Once these PhD studies have been successfully completed, and the PhD examination has been passed, the MHH will award the degree of a Doctor of Philosophy (PhD) or Dr. rer. nat. for natural scientists (not for medical students).

Chapter Two

Requirements for Access and Admission

§ 2 Access (1) Anybody having successfully completed university studies in medicine, veterinary medicine or natural sciences shall have access to PhD studies. (2) Applicants are required to render evidence of above-average results obtained at university. The applicant’s past career must reveal his or her particular qualification for and dedication to scientific work. A physician or dentist will provide evidence of such qualification and dedication by his or her highly expert doctoral thesis in human medicine or dentistry, with at least its experimental or analytical part completed. Decision on whether or not a candidate qualifies for access to PhD studies is up to the PhD Committee (§ 4).

§ 3 Admission to PhD Studies (1) The number of applicants that can be admitted to PhD studies is limited. The number of new applicants admitted annually is 20. The applicants should not be older than 30 years. The PhD Committee shall select the applicants to be admitted (§ 4). As a rule, the President of the MHH will give notice of the date of commencement of PhD studies once a year. (2) The decisive criterion for admission to PhD studies is the overall grade which the student graduated with from university, or the quality of his or her doctoral thesis pursuant to § 2 sub-para. 2. If the number of applicants exceeds the limit, the decision on an applicant’s particular qualification for and dedication to scientific work shall be dependent on a written test (biomedical questions) and on an interview with the PhD Committee and on the quality of the project proposed by him or her, with due consideration of the team’s working conditions. A written protocol of the interview shall be taken. To assess the project, the Committee shall procure an expert report prepared by a university teacher. The result of the interview as well as the quality of the project proposal shall each carry the same weight in the selection of applicants.

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(3) Application papers shall be submitted to the chairperson of the PhD Committee and shall include:

- an informal letter of application for PhD studies indicating the applicant’s particular aptitude and motivation for doing PhD studies and his or her interests and ideas regarding his or her future professional career;

- the application form

- a C.V. including school/university reports and information or certificates on English language skills (and German language skills if applicants are from non-German speaking countries);

- two letters of recommendation

- if applicable: a letter of recommendation prepared by his or her supervisor (§ 4 sub-para. 3) indicating the subject of the research project, confirmation of scientific supervision, confirmation of position, information on planned financing of the research project, and a suggestion for a scientist other than a university teacher to join the co-ordinators’ team (§ 4 sub-para. 3);

- a description of the proposed research project including the most significant aspects of the present state of the art and the project schedule (as agreed with the co-ordinator) or alternatively a detailed description of former research work; the purpose of such description is to demonstrate that this is an ambitious research project promising an important scientific contribution (e.g. Master thesis; medical doctoral thesis)

- designation of the scientific discipline in which the applicant intends to acquire the PhD degree; this discipline should preferably be one of the major foci of the program.

- certificates (4) On the basis of this application the PhD Committee shall decide on admission to PhD studies and determine the discipline in which the student can work for his or her PhD degree.

Chapter Three

PhD Committee

§ 4 PhD Committee (1) The PhD Committee appointed by the MHH senate shall be responsible for the conduct of PhD studies pursuant to the provisions relating to the Requirements and Rules for postgraduate studies and examinations to obtain a PhD (Dr.rer.nat.) degree. (2) The Committee shall be composed of four professors, a university scientist with a doctor’s degree, and a student in an advisory capacity. The members of the Committee shall be appointed by the MHH Senate for a period of four years, or two years as regards the student member. Re-election of the latter shall be admissible. The PhD students shall suggest a candidate from among their ranks. The Committee shall be constituted by the “Forschungsdekan” responsible for research and shall elect a professor from among its ranks as chairman. (3) The Committee will meet regularly, at least every 8 weeks. (4) The Committee will evaluate proposed projects (open projects) according to quality (with external referees if necessary), financial support, guarantee of independence for PhD student. (5) The PhD Committee shall appoint a team of co-ordinators for each PhD student. Such team shall be composed of the student’s personal co-ordinator (a scientist qualified as university teacher in the student’s specific field of research at the MHH), and two further scientists qualified as university teachers whose professional activity shall be closely related to the subject of the project. If no third MHH teacher can be found to join the team, a scientist qualified as university teacher in the student’s field of research but not actually teaching at university can be suggested to join the panel. In the presence of several PhD students doing research in the same line, the respective co-ordinators’ teams can be composed of the same individuals.

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Chapter Four Curriculum

§ 5 Contents of Studies

(1) The contents to be learned shall be conveyed to the students through their experimental or equivalent theoretical research work and through project-related as well as inter-disciplinary research-oriented courses and seminars. For that purpose, the PhD Committee shall prepare and submit, after consultation with the university institutions involved in these studies, a curriculum indicating compulsory and recommended courses or seminars for each discipline. The standard curricula will ensue from the model curriculum shown in Appendix 2 hereto. The courses and seminars shall be held by the teachers and professors of the MHH, the School of Veterinary Medicine, or the University of Hanover, including visiting professors. At least some of the teaching shall be in English. The curriculum may include courses and seminars held at a Graduiertenkolleg. PhD students may also register for suitable courses or seminars offered by other scientific schools (Hanover University, Hanover School of Veterinary Medicine, etc.). Students are encouraged to do active teaching themselves, e.g. by giving lectures at seminars or postgraduate research trainingprogram [Doktorandenkolleg]. Each student’s individual progress at PhD courses and seminars shall be monitored and consistently assessed by the respective teachers on the basis of tests, with teachers preparing written reports on the results obtained by the student. (2) PhD students shall design, after consultation concert with their co-ordinators, their respective individual schedules pursuant to the curriculum established by the PhD Committee. Such individual schedule shall require approval by the respective co-ordinators’ team. The student must complete a minimum of 300 hours at courses and seminars during his or her PhD studies; as a rule, at least 80% thereof must be taken at project-related courses and seminars and up to 20% may be spent on interdisciplinary learning (e.g. experimental techniques and bio-informatics, molecular biology, bio-statistics, scientific communication etc.). The European Credit Point System has been introduced for assessing tuition results.

During the first year of PhD studies, courses for physicians, dentists and veterinarians are intended to provide participants with a chance to consolidate their knowledge of the fundamental principles of natural sciences and courses for natural scientists are intended to consolidate their knowledge in medical aspects. (3) The structure of the PhD program and the modus of granting credit points (cp) according to the European ECTS system is as follows (accreditation according to European standards on December 9th, 2003). For the 3-year program altogether 180 cp have to be achieved:

- Every student will perform a 3-year research project in one of the departments of MHH or partner institutes. Altogether 125 cp are awarded.

- Every student will present his project including an open discussion annually within the department. All Co-supervisors are invited. Altogether 10 cp are awarded.

- For regular visits of and presentations in "Journal Clubs" 3 cp are awarded.

- Every student will present his project and discuss it within an annual public workshop. Before the workshop, a project report has to be handed in. Altogether 10 cp are awarded.

- For presentations (lecture or poster) on congresses/meetings maximal 2 cp are awarded.

- In the first year of study, students attend the obligatory seminars in Basics (2 SWS) and tutorial (1 SWS). At the beginning, specific in-depth seminars for medical students as well as life scientists (seperately) are offered. Altogether 8 cp are awarded.

- In the second year of study, students attend the obligatory advanced seminars with focus on research and applied aspects (2 SWS) and tutorial (1 SWS). Altogether 8 cp are awarded.

- Within 3 years, students will have to attend at least 80 hours of project-orientated seminars, including method courses and practical courses. Altogether 8 cp are awarded.

- Within 3 years, students will have to attend at least 60 hours of interdisciplinary seminars, including "soft skills" (presentation techniques, scientific writing etc.). Altogether 6 cp are awarded.

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PhD students could apply for a leave (e.g. in case of pregnancy), but for no more than 12 month. Short term stays abroad are very much appreciated and will be supported. If students take seminars and courses abroad, they could be acknowledged for the PhD program.

§ 6 Co-ordinators

(1) PhD students shall supervised by the members of their respective team of co-ordinators (§ 4) appointed by the PhD Committee. The responsibilities of the team shall be: a) To act as co-ordinators and to give individual expert advice to PhD students all through their PhD

studies while observing the MHH rules of proper scientific practice. b) To evaluate PhD students’ progress during their studies by reading their reports and conducting tests,

and to assess their written final examination papers. c) Within a time of probation of 6 months, PhD students are evaluated. Within this time peroid, student

status can be omitted easily in agreement with the supervisors and PhD Committee. Within the scope of their research project, students have to work with appropriate methods on a clearly defined subject so that, with some realistic prospect of success, scientific knowledge can be expected to be incremented and the results of such research should be published in international peer review journals. The co-ordinators shall make sure, and satisfy the PhD Committee to that effect, that students are not entrusted with any tasks unrelated to their PhD studies. Physicians registered for PhD studies shall be given an opportunity to do at least part of their pre-license internship (AIP). (2) The co-ordinators shall be responsible for the financing of the respective research project and shall make efforts, during the standard period of PhD studies (three years), to raise the money needed for the PhD students they are in charge of. Any scholarships available at the MHH, e.g. from internal sources such as the HiLF programme or from the Society of MHH Friends [Gesellschaft der Freunde der MHH], shall be awarded by resolution of the PhD Committee. (3) Co-ordinators should assist PhD students in planning their further professional career. (4) The responsibilities of co-ordinators for PhD students shall end upon the date when the latter pass their PhD examination (§ 10), which is normally three years but no later than five years after commencement of PhD studies.

§ 7 Scientific Colloquia PhD students shall be invited once every year by the PhD Committee to attend a public colloquium held at the MHH, giving them an opportunity to give a lecture on the current state of their research. The contents of such lecture, constituting an interim report, shall be submitted in writing by the PhD student to the PhD Committee. The Committee shall decide whether or not this progress report constitutes a sufficient step towards the successful completion of the student’s research. If the Committee’s comment is negative, such result shall be communicated in writing to the student and his or her co-ordinators’ team, indicating the reasons. Pursuant to a period of one month, the student shall submit a modified work plan for the next year of his research, giving due consideration to the recommendations made.

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Chapter Five

Examinations

§ 8 Intermediate Examination The oral intermediate examination shall be held no later than 18 months after commencement of PhD studies. By way of exception, which must be well-founded, the intermediate examination can be taken at a later date. If a student wishes such exception, he shall apply in writing to the PhD Committee adding a comment prepared by his co-ordinators’ team. The dates for intermediate examinations shall be determined by the PhD Committee. The intermediate examination shall be held by the a member of the PhD Committee and an expert (chairman) in the special field and shall cover topics from the student’s research project and from the courses and seminars the student has registered for. The examination usually is held in English. If the student fails the intermediate examination he shall be allowed to retake it once, pursuant to a period of at least three and no more than six months as the co-ordinators’ team may decide. If the student fails again, he or she shall be deemed to have finally and absolutely failed. Following such final and absolute failure the student shall be taken off the register. The “chairman” shall report the result of the intermediate examination to the PhD Committee. The result of the exam will account for 20% of the final mark (PhD or Dr.rer.nat.).

§ 9 Requirements for Signing up for PhD Examination After completion of PhD studies, which is normally at the end of the third year, the PhD examination shall be held by the co-ordinators’ team. The PhD student shall submit the following documents when signing up for the PhD examination: 1. Certificate of regular attendance at and completion of courses and seminars according to the

curriculum, i.e. a total of at least 300 hours (55 cp), and of two colloquia pursuant to § 7; 2. Certificate of intermediate examination; 3. A scientific thesis (dissertation) prepared in English or German by the PhD student on the research

project the student worked on during his or her PhD studies, with introduction, methodology, results, discussion and summary. The thesis shall constitute an essential original scientific contribution to the discipline the student’s research project pertains to;

4. Alternatively (instead of thesis), at least two first author publications in internationally renowned

peer review science journals. The PhD student’s personal contribution to such publications shall be clearly identified. In that context, “accepted” shall be deemed equivalent to “published”. As for this publication requirement, exceptions are possible with reasons to be given by the co-ordinator. The publications must be correlated as regards their subject matter, and shall be supplemented by a detailed description under a joint title in English or German of the research subject, including an overall summary and a discussion of results.

To assess the thesis or the publications, the PhD Committee shall procure at least one external

expert’s opinion. For the Dr. rer. nat., this expert has to be member of a natural science faculty. In addition, the co-ordinators’ team shall prepare an expert report on the dissertation or the publications, and such report together with the external expert’s opinion shall serve the PhD Committee to make their assessment. If one of the expert reports detects any shortcomings in the dissertation, the PhD Committee can be requested to have such shortcomings eliminated or remedied as a precondition for acceptance of the thesis. The chairperson can allow a reasonable period for the PhD candidate to remedy the shortcomings and recommend that he or she submit the thesis anew. In that respect, the chairperson of the PhD Committee can extend this period once only. The experts shall assess the thesis again once the shortcomings have been remedied. If, based on such second experts’ vote, the PhD Committee declines to accept the thesis, the candidate shall be deemed to have failed the PhD examination finally and absolutely. In that case, the PhD student shall be taken off the register.

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§ 10 PhD Examination The PhD examination consists of a public lecture (15 min, in English) held by the PhD student at the Medical School on the subject of his research, a subsequent public disputation of the project of at least 30 minutes of duration to assess the knowledge acquired by the student on the subject of his specific area of research as well as on interdisciplinary subjects. The interview also serves to assess whether the candidate has acquired, and is able to apply, any knowledge and skills relating to the scientific environment of the subject of his research. If the PhD student has opted for any minor subject not represented by the members of his or her co-ordinators’ team, the PhD Committee shall invite to the co-ordinators’ team a professor, or a scientific staff member who is qualified as a university teacher and lectures at the MHH, or an external scientist who in his or her own scientific research has dealt with the subject of the candidate’s research. Only the members of the co-ordinators’ team shall have a vote in deciding on the result of the examination. The assessment of the oral examination follows the Requirements and Rules for Examinations to Obtain a Doctor’s Degree in Natural Sciences set up jointly for the Departments of Natural Sciences at the University of Hanover. The oral examination shall be taken on record in abridged form and shall indicate:

the grade earned for the oral examination, the grade earned for the thesis, the overall grade average earned for the PhD examination.

It shall be signed by the chairman of the board of examiners. The following grades can be awarded: Excellent/ very good/ good / satisfactory / sufficient Equivalent to excellent / summa cum laude, very good / magna cum laude, good / laude, passed / rite. If the candidate fails the final examination he or she shall be allowed to retake it once, pursuant to a period of at least three and no more than six months as the co-ordinators’ team may decide. Should the student then fail again, he or she shall be deemed to have finally and absolutely failed the PhD examination. Following such final and absolute failure the student shall be taken off the register. The result of the PhD examination shall be communicated to the PhD Committee by the Rector’s office.

Chapter Six

The PhD Doctorate

§ 11 Award of the Academic Degree of a Doctor of Philosophy (PhD) Once the student has passed the PhD examination he or she shall be awarded the academic degree of a Doctor of Philosophy (PhD) or a Dr. rer. nat. degree by the MHH. A document as shown in Appendix 1 shall be issued to him or her in evidence of such award. The award shall authorize the candidate to use the academic title of a PhD, PhD or Dr. rer. nat..

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Coming into Effect Pursuant to § 80 sub-para. 1 NHG [Lower Saxon University Act], the foregoing provisions have been approved by the Ministry of Science and Culture (MWK) of the German Federal State of Lower Saxony by decree dated 30 May 2000 providing that a) the introduction shall be limited to an initial period of three years, b) the standard period of studies shall be three years, c) the academic degree of a “Doctor of Philosophy” (PhD) shall be awarded. The Requirements and Rules for Postgraduate Studies and Examinations to Obtain a PhD Degree, as approved by me, are hereby published within this Medical School. They shall come into effect the day after their publication in the official MHH gazette (“MHH-Info”). Hannover, February, 2004

The President Professor Dr. D. Bitter-Suermann