Hazard Ratio 0.62 (0.41-0.94) P = .024

Larynx and Hypopharynx Overall SurvivalLarynx and Hypopharynx Overall Survival

166 Patients

Larynx and Hypopharynx OS and PFSLarynx and Hypopharynx OS and PFS

Hazard Ratio 0.67 (0.41-1.11) P = 0.12

OS “Operable” Hypopharynx and OS “Operable” Hypopharynx and Larynx PatientsLarynx Patients

123 Patients

LFS in the Operable Patient LFS in the Operable Patient PopulationPopulation

Hazard Ratio 0.59 (0.37-0.95) P = .03

TAX 324 – Larynx and HypopharynxTAX 324 – Larynx and HypopharynxConclusionsConclusions

Sequential Therapy with TPF Significantly Improves Sequential Therapy with TPF Significantly Improves Survival in Advanced Larynx and Hypopharynx CancerSurvival in Advanced Larynx and Hypopharynx Cancer– TPF Reduces Mortality by 38% Compared to PF, p = .02TPF Reduces Mortality by 38% Compared to PF, p = .02

Sequential Therapy with TPF Significantly Improves Sequential Therapy with TPF Significantly Improves PFS in Advanced Larynx and Hypopharynx CancerPFS in Advanced Larynx and Hypopharynx Cancer– TPF Improves PFS by 34% Compared to PF, p = .03TPF Improves PFS by 34% Compared to PF, p = .03– TPF Reduces Surgery by 50%, p = .026TPF Reduces Surgery by 50%, p = .026– TPF Reduces Primary Site SurgeryTPF Reduces Primary Site Surgery

TAX 324 – Larynx and HypopharynxTAX 324 – Larynx and HypopharynxRational SpeculationRational Speculation

Sequential Therapy With TPF Significantly Improves LFS in Sequential Therapy With TPF Significantly Improves LFS in Operable Larynx and Hypopharynx Cancer Compared To PF, p Operable Larynx and Hypopharynx Cancer Compared To PF, p = .03= .03

Since TPF Is Significantly Better Than PF, We Could Reasonably Since TPF Is Significantly Better Than PF, We Could Reasonably Expect TPF To Be Significantly Better Than Bolus Cisplatin-Expect TPF To Be Significantly Better Than Bolus Cisplatin-Based CRT Based CRT – PF Is Equivalent To Bolus Cisplatin-Based CRT for LFS and Survival*PF Is Equivalent To Bolus Cisplatin-Based CRT for LFS and Survival*– There Is A Significant Survival and LFS Advantage To TPF Compared There Is A Significant Survival and LFS Advantage To TPF Compared

to PFto PF

*Taylor, 1996, Forastiere, 2006; Lefebvre, 2007*Taylor, 1996, Forastiere, 2006; Lefebvre, 2007