Group 2

Julie Hana

Myrna Hana

Alden Klemm

Julie Guglielmo

Nasser Shehade

Tina Altomeh

Tesha Huston

Detrol LA

Extended-release

Cmax = 75% of normal Detrol formula

Cmin = 150% of normal Detrol formula

Smaller range between peaks and troughs

Taken once daily

Glipizide XL

Extended-release

90% at SS vs. conventional release.

Less peak to trough fluctuations

NuvaRing

Etonogestrel

Cmax = 1,716 pg/mL

Tmax = 200.3 hrs

½ life = 29.3 hrs

CL = 3.4 L/hr

Slowly releases in the vagina

Sustained release

NuvaRing continued

Ethinyl Estradiol

Cmax = 34.7 pg/mL

Tmax = 59.3 hrs

½ life = 44.7 hrs

CL = 34.8 hrs

Sustained-release

Sular

½ life = 7-12 hrs

Cmax = 1.3 pg/mL

Tmax = 6-12 hrs

External and internal core. (external is a slower, extended-release)

Nexium

½ life = 19 hrs

Tmax = 1.5 hrs

In the form of enteric coated granules inside a capsule shell.

Shorter ½ life in plasma, longer half life at site of inhibition (PPI)

Delayed-Release

Aldara

½ life = 10x greater in topical form than in the conventional form

Topical cream

Modified-release

Ortho Evra

AUC and Css are higher

Cmax is lower

Delivered over 7 days versus 1 day

Thin-matrix transdermal patch with 3 layers that extend its release

Extended-Release

Enablex

½ life = 13-19 hours

SS achieved in 6 days

Film-coated tablet, with a very low absorption rate

Extended-Release