11

Promoting the creation, relocation and Promoting the creation, relocation and development of development of biotechcompaniesbiotechcompanies

22

Genopole® : From a Bio-Park to Genopole® : From a Bio-Park to a Bio-Cluster ...a Bio-Cluster ...

Companies

Hospital University

Research

A continuum dedicated to BiotechnologyA continuum dedicated to Biotechnology

33

Genopole® : a Biopark fully integrated in the Genopole® : a Biopark fully integrated in the Medicen Paris Region Bio-clusterMedicen Paris Region Bio-cluster

Non-Profitable Non-Profitable

OrganisationOrganisation Incorporated in 1998Incorporated in 1998 Creation & Development of a Bio-Park : Companies & Creation & Development of a Bio-Park : Companies &

Research LabsResearch Labs

30 Km30 Km

44

Building the most favorable environment Building the most favorable environment to develop Biotech companies… to develop Biotech companies…

International International

NetworkNetwork

Shared Shared

Technical platformsTechnical platforms

Incubation and Incubation and

development development

ProgramsPrograms

VersatileVersatile

Real Estate Real Estate

Offers and ServicesOffers and Services

Clinical Clinical

NetworkNetwork

International International

Scientific Scientific

environmentenvironment

Biotech Biotech CompaniesCompanies

Pre seed FundPre seed Fund

55

20 research labs, incl. 3 national-scale 20 research labs, incl. 3 national-scale

centrescentres more than 900 scientistsmore than 900 scientists From most National Research InstitutesFrom most National Research Institutes

o CNRS, CEA, INSERM, INRA, …CNRS, CEA, INSERM, INRA, …

GenopoleGenopole®®: A stimulating Collaborative : A stimulating Collaborative Scientific & Education EnvironmentScientific & Education Environment

ResearchResearch

Evry University and 3 engineer schoolsEvry University and 3 engineer schools more than 12 000 students (34 % in wet sciences and more than 12 000 students (34 % in wet sciences and

engineering)engineering) and 400 professors and 400 professors

Ambitious Integrative ProgramsAmbitious Integrative Programs iStem : Institute for Stem Cells (2005) iStem : Institute for Stem Cells (2005) iSSB : Institute for Systems and Synthetic Biology iSSB : Institute for Systems and Synthetic Biology

(2009) (2009) Institute for Biomaterials (2010)Institute for Biomaterials (2010)

66

Our facilities include space Our facilities include space from from “plug ‘n play” offices for “plug ‘n play” offices for

entrepreneurs to customisedtenant lab & office spacesentrepreneurs to customisedtenant lab & office spaces

for 50 to 300 m² wet lab & office suitesfor 50 to 300 m² wet lab & office suites Fully equipped with benches, sinks, deionised water, Fully equipped with benches, sinks, deionised water,

autoclave, freezers, rt-PCR, …autoclave, freezers, rt-PCR, …

GenopoleGenopole®®: : more than 83 000 m² dedicated to the more than 83 000 m² dedicated to the development of life science companiesdevelopment of life science companies

Incubator with shared laboratory Incubator with shared laboratory

equipmentequipment

Offices fully furnished, Offices fully furnished, Meeting rooms, ... Meeting rooms, ...

Real EstateReal Estate

Business Center (20-50 m²):Business Center (20-50 m²):

customized spaces / specific demand and lay customized spaces / specific demand and lay

outout for 300 to 2 000 m² and more wet lab, L2 & office for 300 to 2 000 m² and more wet lab, L2 & office

suitessuites

Our facilities include space Our facilities include space from from “plug ‘n play” offices for “plug ‘n play” offices for

entrepreneurs to customized tenant lab & office spaceentrepreneurs to customized tenant lab & office space

Genopole®: Genopole®: more than 80 000 m² dedicated to the more than 80 000 m² dedicated to the development of life sciencesdevelopment of life sciences

Real EstateReal Estate

A new hospital is build on Genopole® campusA new hospital is build on Genopole® campus

GenopoleGenopole®®: : a new hospital and a center for a new hospital and a center for clinical and translational researchclinical and translational research

Latest & Largest General Hospital build in Latest & Largest General Hospital build in

FranceFrance1 000 beds1 000 bedsOpening May 2011Opening May 2011Genopole Genopole coordinates the construction of coordinates the construction of

a a center for clinical and translational researchcenter for clinical and translational research

Clinical

Clinical

3 000 m²3 000 m²New ApproachesNew ApproachesOpening late 2011Opening late 2011

GenopoleGenopole®®: : a team dedicated to foster creation a team dedicated to foster creation and development of biotech companiesand development of biotech companies

IncubationIncubationFinance

Science(s)

IP

Team

Clinic&Reg Scale up

6420

Finance

Science(s)MarketCompet Bus Dev

IP

Team

Clinic&Reg Scale up

6420

MarketCompet. Bus Dev

A Team of 6 multidisciplinary A Team of 6 multidisciplinary

Project ManagersProject Managers

Combining solid complementary Combining solid complementary

backgrounds in pre-incubation, backgrounds in pre-incubation,

IP, finance, valuations, biz. dev., IP, finance, valuations, biz. dev.,

fund raising, licensing, …fund raising, licensing, …

Genopole provides a whole list of services Genopole provides a whole list of services

dedicated to young biotech companiesdedicated to young biotech companies

Genopole®: Genopole®: a list of services to foster the a list of services to foster the development of Biotech companiesdevelopment of Biotech companies

Senior administrative officers, Accounting, Senior administrative officers, Accounting,

quality assurance, onsite IT network support, quality assurance, onsite IT network support,

human resources management, electronic human resources management, electronic

libraries,… libraries,… Genopole Genopole subsidises subsidises an European Grant an European Grant

Service dedicated to SMEs ...Service dedicated to SMEs ...Brings support to preparation and Brings support to preparation and

application phases but also in the application phases but also in the

management of funded projectmanagement of funded projectBureau

Euro

pe Gen

opol

e®

IncubationIncubation

G1J - Genopole pre-seed Life Sciences Capital FundG1J - Genopole pre-seed Life Sciences Capital Fund

Genopole®: with G1J IdF Genopole®: with G1J IdF access access to a pre-seed Fundto a pre-seed Fund

Initial Capital: 2.1 M€ - 16 privateinvestorsInitial Capital: 2.1 M€ - 16 privateinvestors

Investment/project: 50 000 – 100 000 €Investment/project: 50 000 – 100 000 €

« From 1st day to 1st round of financing »« From 1st day to 1st round of financing »

Allowsaccess to the Oseogrant system and to National, Regional& EU grantsAllowsaccess to the Oseogrant system and to National, Regional& EU grants

Equity raise: 6 M€ Equity raise: 6 M€ brings G1J to the Proof of Concept Fund level brings G1J to the Proof of Concept Fund level Investment/project:Investment/project: 300 000 – 500 000 € 300 000 – 500 000 €

IncubationIncubation

G1J - Genopole Regional Life Sciences Capital FundG1J - Genopole Regional Life Sciences Capital Fund

1212

Genopole®: Genopole®: More than 80 currently incorporated More than 80 currently incorporated companies and active projects …companies and active projects …

LTK LTK PharmaPharma

NanoBNanoBHH

GlobalBioEnerGlobalBioEnergygy

TexcellTexcell

GENOPOLEGENOPOLE®® ENTREPRISES ENTREPRISES in 2008in 2008

69 biotechcompanies69 biotechcompanies

1023 FTE1023 FTE

207.81 M€ fundraised207.81 M€ fundraised

144.11 M€ sales / 30 companies144.11 M€ sales / 30 companies

670 granted/penting patents670 granted/penting patents

28 productsfrom IND to Phase III &market28 productsfrom IND to Phase III &market

GenopoleGenopole®®: : State of the art shared technical State of the art shared technical platforms and equipmentplatforms and equipment

Infrastructures

Infrastructures

1313

15 Platforms/Equipments end 200915 Platforms/Equipments end 2009

Management : 13 public labs, 1Management : 13 public labs, 1 private and 1 Genopoleprivate and 1 Genopole

Genopole investmentsGenopole investments~ 20 M€~ 20 M€

Headcount : 68 personsHeadcount : 68 persons

Cumulated surface ~ 4200 mCumulated surface ~ 4200 m22

5 obtained national quality label5 obtained national quality label

2 ISO 9001 v 2000 certification & 2 2 ISO 9001 v 2000 certification & 2 planned in 2009planned in 2009

more than 300 scientific publicationsmore than 300 scientific publications

8 patents/licences8 patents/licences

Sharing expertise, skills and resourcesSharing expertise, skills and resources

GenopoleGenopole®®: : State of the art shared technical State of the art shared technical platforms and equipmentplatforms and equipment

Infrastructures

Infrastructures

1414

CERFE and CERFAP(Animal facility)CERFE and CERFAP(Animal facility) Cell and Small Animal IrradiatorCell and Small Animal Irradiator Imaging and cytometryplatformImaging and cytometryplatform Bioinformatic annotationBioinformatic annotation DNA chips productionDNA chips production Mass spectrometryplatformMass spectrometryplatform Evr@Platform(augmented reality and virtualenvironment)Evr@Platform(augmented reality and virtualenvironment) Plant DNA MicroarrayplatformPlant DNA Microarrayplatform Biophotonics PlatformBiophotonics Platform Structural Biology Platform (NMR, AFM)Structural Biology Platform (NMR, AFM) Transmission electronmicroscopyTransmission electronmicroscopy DNA and cells BankDNA and cells Bank HTS PlatformHTS Platform Cellsorting stationCellsorting station IncubatorsharedequipementsIncubatorsharedequipements

15 Platforms15 Platforms

GenopoleGenopole®®: : GMP production centers for drugs of GMP production centers for drugs of the futurethe future

Infrastructures

Infrastructures

1515

The Present & the FutureThe Present & the Future

A A GMP GMP compliantbiomanufacturingcenter for compliantbiomanufacturingcenter for proteinsproteinsfrommammaliancells (biotherapy, frommammaliancells (biotherapy, monoclonal antibodies)monoclonal antibodies)

A A GMPGMPcompliantcompliantviral vectorviral vectorbioproduction center bioproduction center (Genethon)(Genethon)

A production centre of A production centre of enzymesenzymes and and biocatalysisbiocatalysis for industrial use. for industrial use.

A A GMP biomanufacturingGMP biomanufacturingcentre using alternative centre using alternative techniques : techniques : bacteriabacteria, , yeastyeast, , plantsplants……

An An GMPoligonucleotidesGMPoligonucleotides production center in production center in partnershippartnership

A Laboratory to develop and optimise the best A Laboratory to develop and optimise the best expression systemsexpression systems

A centre for A centre for filling, packaging and filling, packaging and deliveringdeliveringproductsunderproductsunderGMPGMPcompliantcompliant

GenopoleGenopole®®: : State of the art shared technical State of the art shared technical platforms and equipmentplatforms and equipment

Infrastructures

Infrastructures

1616

65 % of the companies use the platforms network (25% use more than 3 platforms)65 % of the companies use the platforms network (25% use more than 3 platforms)

For 25% of the companies, the decision of location in Genopole is closely linked For 25% of the companies, the decision of location in Genopole is closely linked to the presence of specific platformsto the presence of specific platforms

Platforms have significantly promoted the development of 50% of the companiesPlatforms have significantly promoted the development of 50% of the companies

Platforms : a major leverage for businessPlatforms : a major leverage for business

Genopole platforms : Opening from local to international level Genopole platforms : Opening from local to international level

25% local / 25% regional & national / 25% European / 25% international25% local / 25% regional & national / 25% European / 25% international Local opening for technical facilities (proximity effect)Local opening for technical facilities (proximity effect) Research programs at National / European and International levelResearch programs at National / European and International level

Level of opening depends onLevel of opening depends on Technical & Scientific expertiseTechnical & Scientific expertise Services (originality, quality,…)Services (originality, quality,…) Capacity of partnering (platform business dev., users networks)Capacity of partnering (platform business dev., users networks)

Genopole manages an international networkGenopole manages an international network

GenopoleGenopole®®: : an international network oriented to an international network oriented to biotech companies biotech companies

with international Cies, pharma with international Cies, pharma

laboratories, foreign bioincubators and laboratories, foreign bioincubators and

international venture capital institutions,international venture capital institutions,Genopole is member of several European Genopole is member of several European

consortium with European bioparksconsortium with European bioparks

InternationalInternational

BioLink (FP5) BioLink (FP5) Oxford, Munich, Cagliari, Jerusalem, Oxford, Munich, Cagliari, Jerusalem,

CardiffCardiff

Natibs (FP6) Natibs (FP6) Berlin, Barcelona, Karolinska, Tallinn, Tel Aviv, Berlin, Barcelona, Karolinska, Tallinn, Tel Aviv,

InnoInno

CEBR (FP6) CEBR (FP6) Cambridge, Oxford, Berlin, Munich, Heidelberg, Barcelona, Uppsala, Cambridge, Oxford, Berlin, Munich, Heidelberg, Barcelona, Uppsala,

Tallinn, LyonTallinn, Lyon

Bio-CT (FP7) Bio-CT (FP7) Torino, Cambridge (CEBR), Barcelona, Berlin, Debrecen &InnoTorino, Cambridge (CEBR), Barcelona, Berlin, Debrecen &Inno

GenopoleGenopole®®: : 135 M€ invested from 1998 to 2008135 M€ invested from 1998 to 2008

GenopoleGenopole®®: : 135 M€ invested from 1998 to 2008135 M€ invested from 1998 to 2008

GENOPOLE - 1998

GENSET

UNIVERSITY

National Sequencing Center

(GENOSCOPE)

BiofordsConsultants

AFM / GENETHON

INCUBATOR

Evry in 1998Evry in 1998

Neurotech

Biotech Companies

Academic Research

2323

20research labs20research labs - 900 jobs- - 900 jobs- 69 biotech companies 69 biotech companies – 1 000 jobs-– 1 000 jobs- A comprehensive A comprehensive 83 000 m² 83 000 m² real estate real estate

offeroffer A team A team dedicated to developmentdedicated to development Services and a Europe Grant serviceServices and a Europe Grant service 16platforms and equipments16platforms and equipments CorbeilEvryCorbeilEvryHospitalHospital& Clinical& Clinical

and and Translational Research CenterTranslational Research Center GMP GMP BiomanufacturingBiomanufacturingCenter opening Center opening

soon and 4 others biomanufacturing soon and 4 others biomanufacturing project runningproject running

Our achievements ...Our achievements ...

2424

ContactContact::communication@genopole.frcommunication@genopole.fr