GENERAL INFORMATION Title I 19th Congress of the Asian Pacific Society of Respirology

Date I 13-16 November 2014

Venue I Bali Nusa Dua Convention Center (BNDCC), Kawasan

Pariwisata Nusa Dua Lot NW/1, Nusa Dua, Bali 80363, Indonesia, http://www.baliconventioncenter.com Located in the Southern Bali, Bali Nusa Dua Convention Center (BNDCC) is only 20 minutes away by car from the International Airport and has an easy access to transport by a taxi.

Host Organization I Indonesian Society of Respirology (ISR)

Language I The Official language of the Congress is English. No

translation will be provided except specified session.

Invited Speakers Distinguished speakers from American Thoracic Society, European Respiratory Society, Japanese, Respiratory Society, America Latin Thoracic Society, American College Chest Physician, and APSR.

Inquiry to APSR 2014

APSR 2014 Secretariat Head Office Department of Pulmonology and Respiratory Medicine Faculty of Medicine, University of Indonesia Persahabatan Hospital, Jalan Persahabatan Raya No.1 Rawamangun, Jakarta 13230, Indonesia Phone : +62-21-4705684 ; +62-21-70726355 Fax : +62-21-47869389/+62-21-4705684 email: apsrindonesia@gmail.com APSR 2014 Oversea Queries 6 Shenton Way, # 15-08 DBS Building Tower 2 Singapore 068809 Phone : +65-62907400 Email: secretariat@apsr2014.org

Business Center Business center is located in ground floor. The services are at the participants’ own expense. Exhibition Access to the exhibition will be limited to respiratory professionals. Children accompanied or unaccompanied are forbidden from entering this area. E-Poster Area All author of an accepted abstract will be encouraged to create an electronic version of their work before the Congress. In addition to their assigned type of presentation (e.g. Poster Discussion, Thematic Poster or Oral Presentation). Delegates, authors and chairs will be able to communicate and post comments on the presented data via a chat forum during and after the Congress. Further information: The electronic platform available at the Congress is a medium for presenting work during a live event. As with Thematic Posters, data presented electronically are not considered to be publishes or pre-publish. They are not available for review and may not be quoted, copied or downloaded. With the author’s agreement, they will be made available online after the Congress. Copyright remains with the author. Children and Accompanying Persons Children and members of the public are not permitted in the exhibition area or any room hosting an industry activity. In addition, the APRS ask delegates and faculty to refrain from taking children to any scientific sessions or practical demonstrations. In the event that children are required to enter the congress Centre they should be supervised by an adult at all times and observe the restrictions that apply to limited access areas. In the event that a member of public is invited to participate in the APRS Congress scientific programme, they should be accompanied by a qualified healthcare professional or APRS representative, observing the APRS restrictions where appropriate. Dress Code Dress will be informal throughout the Congress. APRS reserves the right to refuse access if it is deemed necessary for the comfort and safety of all delegates.

Welcome Message

On behalf of the Asian Pacific Society of Respirology, it is my great pleasure to invite you to join us in Bali, Indonesia for the upcoming 19th Congress of the Asian Pacific Society of Respirology (APSR 2014). This occasion will be held on 13-16 November 2014 and it will attended by about 2,500 participants from Asia Pacific and the region, c comprise of researchers and clinicians in the field of respiratory medicine.

We are developing an attractive program with enhanced scientific and educational sessions to explore the latest developments, medical advances, cutting edge treatments, and breakthroughs in the management of respiratory medicine. This congress will also provide opportunities for meaningful engagements between you and the industry partners, high prescribers, and other respiratory medicine professionals. Please visit our website www.apsr2014.org for online registration.

We look forward to seeing you at the congress.

Prof. Dr. Faisal Yunus, PhD

Congress President, APSR 2014

Online Registration www.apsr2014.org/registration The deadline for online registration on 10 November 2014. Registration and payment made on 10 November, 2014 will be based on the on-site fees.

Pre-registration The registration form and payment (by bank transfer or credit card) on 31 October 2014. After this date, payment is only possible by credit card.

Badges, voucher, etc Delegates, who register after 25 September, 2014 will receive badges and other materials on-site in the Congress registration area.

Congress Bag The Congress bag will be available on “first come, first served” basis.

Registration opening hours

Day Date Opens Closes Thursday 13 November, 2014 08:00 15:00

Friday 14 November, 2014 07:00 17:30

Saturday 15 November, 2014 07:00 17:30

Sunday 16 November, 2014 07:00 12:00

All time are subject to change

Accepted modes of payment 1. Bank Transfer

Account Holder: KOPASEBA Bank address: Kompleks Ruko Mega Indah Blok A Jl. Balai Pustaka Timur No.39, Rawamangun, JKT Bank Name: Mandiri Branch Name: KCP Rwgn Balai Pustaka USD Account No: 006-00-0756454-9 Swift Code: BMRIIDJA Please indicate “free of charge for the receiver account” and give your full name and registration number.

2. Credit Card

Visa and MasterCard. Credit card will be debited in USD.

Cancellation Registration can be cancelled up to 24.00 on 25 September, 2014, must be notified of the cancellation in writing. Registration fee refund, minus a 25% administration charge, will be made after the Congress. There will be no refund for cancelation made after 25 September, 2014.

Registration Fee

POSTGRADUATE COURSES & WORKSHOPS

NORMAL RATE

STUDENT RATE

PG Course: Update on Lung Cancer USD 100 USD 50

PG Course: Respiratory Neurobiology and Sleep

USD 100 USD 75

PG Course: Pathogenesis of COPD USD 100 USD 75

PG Course: MDR-TB (Half day) USD 100 USD 75

PG Course: Lung Infection (Half day) USD 100 USD 75

Workshop on Basic & Advances of Lung Infection

USD 150 USD 75

Workshop on Mechanical Ventilation USD 350

USD 150

Workshop on Bronchoschopy 1 USD 350

Workshop on Bronchoschopy 2 USD 350

Workshop on Pleural Disease USD 350

Conference registration is prerequisite for the postgraduate course and workshop admittance.

Workshop attendance is optional. Admittance to the workshop will strictly be available to confirmed workshop registrants only.

Registration will be open until 15 Sep 2014 or when seats are fully booked, whichever comes first. Individual workshop fee applies as listed above.

Fee includes: Admittance, Refreshment, and Certificate of Attendance.

DELEGATE EARLY-BIRD RATE

SAVE USD 100 Now (by 15 Sep 2014)

FULL RATE

Specialist USD 150 USD 800

APSR Member USD 300 USD 650

Allied Healthcare

Professional USD 300 USD 400

Student USD 250 USD 350

Accompanying

Person USD 150

Add: Gala Dinner &

Cultural Night USD 100

Access to the main conference, its symposiums, lunches and gala dinner & cultural night will strictly be granted to BADGE HOLDERS only. Please note that all attendees must register.

Registration confirmation will be issued upon payment received at prevailing rate on the date of payment. Confirmed registrant's badge can be collected upon arrival at the congress venue.

Fee includes: Name Badge, Conference Bag, Program Book, Refreshments, Lunches, Access to Conference Sessions and Trade Exhibition Area, Certificate of Attendance.

Accompanying Person Fee includes: Access to Trade Exhibition Area and General Area Only.

Confirmation On receipt of a completed registration form and the correct fee, each participant will receive electronic confirmation of their registration. An individual email address must be provided.

INFORMATION REGISTRATION

Abdullah Abdul Rahman Al Shimemeri (SAU)

Achmad Hudoyo (INA)

Agus D Susanto (INA) Albert Li (HKG)

Albert Oluwasegun

Alejandro Casas Herrera (ALAT)

Andrew Churg (CAN) Antonio Anzuetto (USA)

Anwar Jusuf (INA)

Arata Azuma (JPN)

Arifin Nawas (INA) Asif M Mahmud (BGD)

Atul Malhotra (ATS)

Bambang Supriyatno (INA)

Bambang Wahju Prayitno (INA) Boedi Swidarmoko (INA)

Bruce Robinson (AUS)

Budhi Antariksa (INA)

Carole L. Marcus (USA) CC Leung (HKG)

Charles Yu (PHL)

Chen Yuan Chiang (CHN)

Chol Shin (KOR) Chong-Kin Liam (MYS)

Christine Jenkins (AUS)

Christopher KW Lai (HKG)

Chuck Daley (USA) Chunxue Bai (CHN)

Curtis Sessler

Darmawan (INA)

David Hui (HKG) David Lam (HKG)

David Price (AUS)

Dean Schraufnagel (USA)

Dianiati Sutoyo (INA) Dicky Soehardiman (INA)

Eiso Hiyama (JPN)

Elisna Syahruddin (INA)

Erlina Burhan (INA) Fachrial Harahap (INA)

Faisal Yunus (INA)

Fu Qiang-Wen (CHN)

Francis Drobniewski (GBR) Ganesh Raghu (USA)

Gary Anderson (AUS)

Gary Lee (AUS)

Gerald Chua (SIN) Geraldo Lorenzi-Filho (BRA) G.B. Magliori (ITA) Greg King (AUS) Harvey O. Coxson (CAN) Hervey Dutau (FRA) Hiroshi Kawane (JPN)

IB Rai (INA)

Isnu Pradjoko (INA)

J Christian Virchow (DEU)

Jamal Zaini (INA)

Jennifer Mendoza (PHIL) Jin Ping-Zheng (CHN) Jorgen Vestbo (DNK) Judith Mackay (HKG)

Jun-Hee Woo (KOR)

Kang Jian (CHN)

Kazuhisa Takahashi (JPN) Kazuma Kishi (JPN)

Kazuo Chin (JPN)

Kenneth Tsang (HKG)

Kimura Hiroshi (JPN) Koichi Hagiwara (JPN)

Koji Narui (JPN)

Kwun Fong (AUS)

Laksmi Wulandari (IDN) Le Thi Tuyet Lan (VNM) Lionel Mandell (CAN) Low Su Ying (SGP) M. Amin (INA)

M. Isa (INA)

Maneechotesuwan Kittipong (THA)

Mario Castro

Mary S-M Ip (HKG) Masaharu Nishimura (JPN) Masahito Ebina (JPN)

Masakazu Ichinose (JPN)

Masayuki Hanaoka (JPN) Masayuki Shima (JPN)

Matsuyama Shutoku (JPN)

Menaldi Rasmin (INA)

Michael Weschler (USA) Miche Cheong (JPN) Michiaki Mishima (JPN)

Mukhtar Ikhsan (INA) Muljadi (INA)

Nan-Shan Zhong (CHN)

Ngo Quy Chau (VNM)

Nicholas Hill (USA) Nirwan Arief (INA)

Nobuhiro Tanabe (JPN)

Norbert Berend (AUS)

Noriaki Kurimoto (JPN) Oea Khairsyaf (INA)

Omar Usmani (GBR)

Paul Enright (USA) Paul Jones (GBR) Peter J. Barnes (GBR) Peter G. Gibson (AUS)

Philip Eng (SGP) Philip Hopewell (USA) Phua Ghee Chee (SGP) Prasenohadi (INA)

Priyanti Soepandi (INA)

Pyng Lee (SGP)

Ratnawati (INA)

Reviono (INA) Richard Lake (AUS)

Richard Light (AUS)

Rodriguez Panadero (ESP)

Ronald Grossman (CAN) Rosemary S. Horne (AUS) Roslina Manap (MAL) Sang-Du Lee (KOR)

Sardikin Giriputro (INA)

Shu Hashimoto (JPN)

Sita Andarini (INA) Soedarsono (INA)

Soon-Hee Jung (KOR)

Stephen Crane

Suradi (INA) Susanty Djajalaksana (INA)

Sutji Mariono (INA)

Suzanne Hurd

Takahide Nagase (JPN) Takashi Ishida (JPN)

Takashi Nakano (JPN)

Takatoshi Kasai (JPN)

Takehiko Hiramoto (JPN) Talant Sooronbaev (KGZ)

Tamaoki J (JPN)

Tan Tze Lee (SGP)

Teguh Sartono (INA) Teresita De Guia (PHIL)

Teruomi Miyazawa (JPN)

Thomas Ferkol (ATS) Thomas M. File Jr (USA) Thomas W Hesterberg (USA)

Tjandra Yoga Aditama (INA)

Tomoko Betsuyaku (JPN) Toshiaki Kikuchi (JPN)

Toshihiro Nukiwa (JPN) Triya Damayanti (INA) Vijayan V.K. (IND) Wahju Aniwidyaningsih (INA) Wang Hui (CHN) Winariani (INA) Wiwien Heru Wiyono (INA) Yasuhiro Kondo (JPN) Yasutaka Nakano (JPN) Yoshiharu Ohno (JPN) Yoshikazu Inoue (JPN) Yoshiki Ishii (JPN) Yoshinosuke Fukuchi (JPN)

LIST OF SPEAKERS & CHAIRMANS

TIME TABLE SCIENTIFIC SCHEDULE

09.00 – 12.00 Postgraduate Course COPD : Pathogenesis

of COPD and Disease Phenothype of COPD

Chairs: Sang-Du Lee (KOR), M. Amin (INA)

Course introduction, Sang-Du Lee (KOR)

09.00 Pathogenesis of COPD, Tomoko Betsuyaku (JPN)

09.30 Phenotyping of COPD from Asian Perspective,

Sang-Du Lee (KOR)

10.00 Asthma COPD overlap syndrome, Peter G. Gibson (AUS)

10.30 Break

11.00 GOLD documents: current issue? Jorgen Vestbo (DNK)

11.30 Assessment of exacerbation, Paul Jones (GBR)

12.00 Lunch

09.00 – 12.00 Postgraduate Course : MDR Tuberculosis

Chairs : G.B. Magliori (ITA), Soedarsono (INA)

Course introduction, G.B. Magliori (ITA)

09.00 Challenge of Drug Resistance TB in Asia and Western Pacific,

Chiang Chen Yuan (CHN)

09.15 Implementing ISTC to Prevent MDR,

Philip Hopewell (USA)

09.30 How MDR developed, Francis Drobniewski (GBR)

10.00 Treatment of MDR and XDR TB, GB Magliori (ITA)

10.15 Second line anti TB drugs: Mechanism of action and rational

for use, Chiang Chen Yuan (CHN)

10.30 Break

11.00 TB MDR among HIV patient, Charles Yu (PHL)

11.15 Adverse event of second-line drug, Erlina Burhan (IDN)

11.30 Countries Experiences, Indonesia, Philippine, Thailand, Hong

Kong, Taiwan, Charles Yu (PHL)

12.00 Lunch

13.00 – 16.00 Postgraduate Course : Pneumonia

Chairs: Jun-Hee Woo (KOR), Priyanti Soepandi (INA)

Course introduction, Jun-Hee Woo (KOR)

13.00 Burden of CAP in Asia Pacific region, Jun-Hee Woo (KOR)

13.25 CAP in TB endemic countries, Vijayan (IND)

13.50 Treatment approach in CAP, HAP/HCAP, Jun-Hee Woo(KOR)

14.15 Pulmonary mycosis: what we have learned, Philip Eng (SGP)

14.40 Break

15.00 Hajj Pilgrim and Viral Pneumonia, Abdullah Abdul

Rahman El SHimemeri (SAU)

15.25 Viral pneumonia: diagnosis and management,

Matsuyama Shutoku (JPN)

15.50 Closing

09.00 – 15.00 Postgraduate Course Assembly of

Respiratory Neurobiology and Sleep

Chairs: Mary S-M Ip (HKG), Kazuo Chin (JPN)

Course introduction, Kazuo Chin (JPN)

09.00 Overview: Sleep-related breathing disorders and their

treatment, Kazuo Chin (JPN)

09.30 Sleep-related breathing disorders in Indonesia,

Agus D. Susanto (INA)

10.00 Clinical characteristics including cephalogram in SDB,

Mary S-M Ip (HKG)

10.30 Break

11.00 Methods of sleep testing: polysomnography and portable

monitoring, Miche Cheong (JPN)

11.30 OSA and pathophysiology including sustained and

intermittent hypoxia, Geraldo Lorenzi-Filho (BRA)

12.00 Lunch

13.00 OSA and cardiovascular, metabolic complications and the effects

of treatment, Chol Shin (KOR)

13.30 Sleep apnea and heart failure, Takatoshi Kasai (JPN)

14.00 Sleep apnea in children: diagnosis and management,

Carole L Marcus (USA)

09.00 – 16.00 Postgraduate Course (ESAP) : Updates of

Lung Cancer

Chairs: Kwun Fong (AUS), Anwar Jusuf (IDN)

09.00 Course introduction, Kwun Fong (AUS)

09.10 Molecular diagnosis of lung cancer, Eiso Hiyama (JPN)

09.35 Lung cancer stem cell, Toshiaki Kikuchi (JPN)

10.00 Thoracic CT pattern in lung cancer: correlation of CT and

pathological diagnosis, Kazuma Kishi (JPN)

10.30 Break

11.00 Genetic heterogeneity in lung cancer, Chunxue Bai (CHN)

11.25 The new WHO lung cancer proposal changes,

Kwun Fong (JPN)

12.00 Lunch

13.00 Welcome back from lunch and summarize morning,

Kwun Fong (JPN)

13.10 Targeted agent in lung cancer: EGFR TKI and beyond,

David C Lam (HKG)

13.25 Lung tumor immunology, Bruce Robinson (AUS)

14.00 Neuroendocrine tumors of the lung, Chong-Kin Liam (MAL)

14.30 Break

15.00 SCLC: what we have now, Chunxue Bai (CHN)

15.25 Lung cancer: The future ahead, Koichi Hagiwara (JPN)

15.50 Closing

PROGRAMME DETAILS POSTGRADUATE COURSE

Thursday, 13 November 2014

09.00 – 16.00 Lung Function: Patient-Oriented PFTs to Assist Clinical Decision-Making

Chairs: Paul Enright (USA), Ratnawati (INA) 09.00 Course Introduction, Anatomy of the lung and basic lung function, Triya Damayanti (INA) 09.20 Clinical application of pulmonary testing, Yasutaka Nakano (JPN) 09.40 Evaluation of lung function in chronic disease, Le Thi Tuyet Lan (VNM) 10.00 Case presentation adult smokers 10.30 Break 11.00 Hands-on Pocket spirometry & diagnostics spirometry, Paul Enright (USA) 11.20 Case Presentation patient with episodic wheezing, Paul Enright (USA) 11.40 Hands-on spirometry, PEF meter and eNO testing, Paul Enright (USA) 12.00 Lunch 13.00 Case Presentation of slow onset dyspnea, Paul Enright (USA) 13.20 DLCO demonstration, Paul Enright (USA) 13.40 Bodyphletysmograph: principles and technique, Paul Enright (USA) 14.00 Changes in lung volume in Various disease, Paul Enright (USA) 14.20 Case presentation - interactive discussion, Paul Enright (USA) 14.40 Break 15.00 Hands-on, Triya Damayanti (INA), Paul Enright (USA)

09.00 – 16.00 Pleural Disease and Thoracoscopy Chairs: Gary Lee (AUS), Menaldi Rasmin (INA) Course Introduction, Menaldi Rasmin (INA) 09.00 Pleural disease: what should we know? Richard Light (USA) 09.15 Thoracic ultrasound: guidance to thoracic procedures, Gary Lee (AUS) 09.30 Closed pleural biopsy: Does it still have value? Menaldi Rasmin (INA) 09.45 Percutaneous pleural biopsy: Fine needle or core biopsy, Menaldi Rasmin (INA) 10.00 Diagnostic and therapeutic thoracoscopy, Pyng Lee (SIN) 10.15 Flex-rigid and rigid thoracoscopy: when to choose and the drawback, Pyng Lee (SIN) 10.30 Break 11.00 Indwelling pleural catheter in MPE, Gary Lee (AUS) 11.15 Pleurodesis: Its value on pleural diseases, Rodriguez Panadero (ESP) 11.30 Case discussion 12.00 Lunch 13.00 Hands-on 13.00 1. Indwelling Pleural Catheter 13.40 2. Rigid Pleuroscopy 14.20 3. Percutaneous Pleural Biopsy 15.00 4. Flex-rigid Pleuroscopy

09.00 – 16.00 Bronchoscopy 1: Managing Airway Stenosis and Corpus Alienum Chairs: Boedi Swidarmoko (INA), Oea Khairsyaf (INA) 09.00 Course Introduction, Objectives, and Anatomy for Bronchoscopy, Boedi Swidarmoko (INA)

09.15 Rigid bronchoscopy: its role in recent airway stenosis and malacia, Herve Dutau (FRA) 09.30 Airway stenting, Herve Dutau (FRA) 09.45 Useful techniques in airway stenosis, Teruomi Miyazawa (JPN) 10.00 EBUS in airway stenosis, Noriaki Kurimoto (JPN) 10.15 What to do for corpus alienum aspiration, Boedi Swidarmoko (INA) 10.30 Break 11.00 CT mapping for EBUS, Takashi Ishida (JPN) 11.15 Endobronchial tuberculosis, Wahju Aniwidyaningsih (INA) 11.30 Case presentation, Wahju Aniwidyaningsih (INA) 12.00 Lunch 13.00 Hands-on 13.00 1. Rigid bronchoscopy and airway stenting 13.40 2. EBUS TBNA 14.20 3. Corpus alienum 15.00 4. Bronchoscopy

09.00 – 16.00 Bronchoscopy 2: Peripheral Lung Nodules and Interventional Bronchoscopy for Asthma

Chairs: Isnu Pradjoko (IDN), Nirwan Arief (IDN) 09.00 Course Introduction, Objectives and Anatomy for bronchoscopy, Dicky Soehardiman (IDN) 09.20 CT assessment for pulmonary nodules, Kazuma Kishi (JPN) 09.40 Principles of EBUS, Noriaki Kurimoto (JPN) 10.00 EBUS in staging mediastinal nodes, Noriaki Kurimoto (JPN) 10.30 Break 11.00 tba 11.20 Lung mapping with CT and biopsy for peripheral lung lesion, Takashi Ishida (JPN) 11.40 Interventional bronchoscopy for asthma management: Bronchial Thermoplasty, Michael Wechsler (USA) 12.00 Lunch 13.00 Hands on 13.00 1. Bronchoscopy + lung mapping 13.40 2. EBUS TBNA 14.20 3. Lung Mapping 15.00 4. Bronchial Thermoplasty

09.00 – 16.00 Lung Mechanical Ventilation Chairs: Gerald Chua (SIN), Prasenohadi (INA) 09.00 Course Introduction, Prasenohadi (INA) 09.10 Overview of mechanical ventilation: modes of mechanical ventilation, Bambang Wahju Prayitno (INA) 09.40 Monitoring of Mechanical Ventilation, Albert Oluwasegun 10.30 Break 11.00 Mechanical ventilation approach in ALI and ARDS, Phua Ghee Chee (SIN) 11.30 Auto PEEP: mechanical ventilation in COPD and chronic lung disease, Gerald Chua (SIN) 12.00 Lunch 13.00 Weaning: how to overcome difficulty weaning, Gerald Chua (SIN) 13.30 Noninvasive ventilation for chronic lung disease, Nicholas Hill (USA) 14.00 Case presentation, Prasenohadi (INA) 14.40 Break 15.00 Dry workshop

PROGRAMME DETAILS WORKSHOP

Thursday, 13 November 2014

08.00 – 09.30 Asthma Congress Symposia. Small Airway Disease in Asthma and Severe Asthma Chairs: Greg King (AUS), Susanty Djajalaksana (INA) 08.00 Small airways in asthma: pathogenesis, Masakazu Ichinose (JPN) 08.30 Clinical phenotype of severe asthma, Greg King (AUS) 09.00 Does the treatment of the small airways matter? Omar Usmani (USA)

09.45 – 10.45 Pfizer Corporation. Pre-Lunch Symposium. Optimizing Management of Respiratory Tract Infections: Are Bugs in Asia Getting Smarter? Chair: Faisal Yunus (INA) 09.45 Changing trends in bacterial resistance in Asia: truth or myth? Wang Hui (CHN) 10.00 Respiratory tract infections: from community to the hospital. Has anything changed? Thomas M. File Jr (USA) 10.30 Discussion

11.00 – 12.00 Boehringer Ingelheim. Lunch Symposium. Chair: Faisal Yunus (INA Optimizing Bronchodilation and Improving Outcomes in COPD, Antonio Anzueto (USA)

13.00 – 15.00 Clinical Allergy and Immunology Assembly Symposia. Current Topics on Asthma and COPD Pathogenesis

Chairs: Shu Hashimoto (JPN), Ian Yang (AUS)

13.00 Molecular targeting therapy, tba 13.30 Genetic Background, tba 14.00 Airway secretion, Tamaoki J (JPN) 14.30 Airway epithelial cells in asthma pathogenesis, Shu Hashimoto (JPN)

15.15 – 17.15 Asthma Assembly Symposia. Asthma COPD Overlap Syndrome (ACOS) Chairs: Maneechotesuwan Kittipong (THA), IB Rai (INA) 15.15 Prevalence, diagnosis and classification of asthma-COPD overlap syndrome, tba 15.40 Cellular mechanism of asthma, Gary Anderson (AUS) 16.05 What's new in the pathogenesis of asthma, Michiaki Mishima (JPN) 16.30 Management recommendation, Maneechotesuwan Kittipong (THA) 16.55 Future Therapies in Asthma, Peter Barnes (GBR)

08.00 – 09.30 Lung Cancer Congress Symposia. Mediastinal Tumor Chairs: Achmad Hudoyo (INA), David Lam (HKG) 08.00 Current diagnostic approach for the mediastinal tumor, Gary Lee (AUS) 08.30 Staging system and treatment of thymoma, David Lam (HKG) 09.00 Discussion

09.45 – 10.45 Mundipharma Pte Ltd. Pre Lunch Symposia. Beyond Asthma Control Chairs: Sang-He Cho (KOR) 09.45 Optimizing proven therapies to achieve asthma control, tba 10.00 Factor beyond asthma control in the real world, David Price (AUS)

11.00 – 12.00 Daiichi Sankyo. Lunch Symposium. Optimal strategy for CAP

Chair: Arifin Nawas (INA) Treatment for community acquired pneumonia, Lionel Mandell (CAN)

Practice Guideline on CAP in Indonesia, Priyanti Soepandi (INA)

13.00 – 15.00 Lung Cancer Assembly Symposia. Targeted Strategies and Beyond in NSCLC Chairs: Kwun Fong (AUS), Elisna Syahruddin (INA) 13.00 Current molecular targets in NSCLC, Koichi Hagiwara (JPN) 13.30 Recent advances of molecular diagnosis for cancer, Eiso Hiyama (JPN) 14.00 Secondline treatment and beyond of targeted therapy in NSCLC, Kazuhisa Takahashi (JPN) 14.30 Gene sequencing and immunotherapy in lung malignancies, Bruce Robinson (AUS)

15.15 – 17.15 Cellular and Molecular Biology Assembly Symposia. Hot Topics in Respiratory Cellular and Molecular Biology

Chairs: tba 15.15 Molecular mechanisms of airway inflammation and remodeling in respiratory disease, tba 15.45 Hot topics in experimental animal model, Takahide Nagase (JPN) 16.15 Pulmonary Stem Cell: role in lung disease pathogenesis and therapy, Toshiaki Kikuchi (JPN) 16.45 Epithelial messenchymal transition in airway epithelial cells, tba

08.00 – 09.15 Respiratory Neurobiology and Sleep Congress Symposia. OSA in Asia Pacific and the Burden of Disease Chairs: Budhi Antariksa (INA), Mary S-M Ip (HKG) 08.00 OSA in Asia Pacific: next burden disease? Koji Narui (JPN) 08.30 OSA: cardiovascular and metabolic complications: next threat? Chol Shin (KOR) 09.00 OSA: organization of care to reduce disease burden, Atul Malhotra

PROGRAMME DETAILS I Friday, 14 November 2014

09.45 – 10.45 Zambon. Pre-Lunch Symposium. Looking Beyond FEV1: New Mechanisms and Clinical Outcomes with NAC at High Doses in COPD Chair: Wiyono Heru (INA) 09.45 Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial Jin Ping-Zheng (CHN) 10.00 High dose N-Acetylcysteine in COPD: Focus on small airways function, Fu Qiang-Wen (CHN) 10.30 Discussion

11.00 – 12.00 Boston Scientific Asia Pacific. Lunch Symposium

13.00 – 15.00 Respiratory Neurobiology and Sleep Assembly Symposia. Advances in OSA Pathophysiology, Comorbidity and Treatment Chairs: Gerado Lorenzi-Filho (BRA), Kazuo Chin (JPN) 13.00 Recent advances in cardiovascular comorbidity in OSA, Geraldo Lorenzi-Filho (BRA) 13.30 Metabolic disorders and comorbidity in OSA, Kazuo Chin (JPN) 14.00 Fluid shift in patients with the sleep disordered breathing, Takatoshi Kasai (JPN) 14.30 CPAP and non-CPAP treatment for OSA, Mary S-M Ip (HKG)

15.15 – 17.15 Lung Infection (Tuberculosis) Assembly Symposia. Achieving Zero TB: Make it Happen Chairs: GB Migliori (ITA), Arifin Nawas (INA) 15.15 Preventing TB Disease: improving the diagnosis and treatment of TB infection, Chuck Daley (USA) 15.40 Latent TB; treat or not to treat, Dean Schraufnagel (USA) 16.05 Moving towards TB elimination: experience and lesson learned through ERS engagement in Europe, GB Magliori (ITA) 16.30 Public Private Mix in TB management, Erlina Burhan (INA) 16.55 Current situation in Asia Pasific: what we have learn, CC Leung (HKG)

08.00 – 09.30 COPD Congress Symposia. Current Issues COPD in Asia Pacific Chairs: M. Isa (INA), Nan-Shan Zhong (CHN) 08.00 The role biomass in COPD, Faisal Yunus (INA) 08.20 Phenotyping of COPD from Asian Population, Sang-Du Lee (KOR) 08.40 Air pollution and COPD in China, Nan-Shan Zhong (CHN) 09.00 Community-based COPD management, Ngo Quy Chau (VNM) 09.20 Discussion

13.00 – 15.00 Lung Structure and Function Assembly Symposia. Phenotyping of Lung Disease Chairs: Yasutaka Nakano (JPN), Fachrial Harahap (INA) 13.00 Phenotyping lung disease using computed tomography (CT), Yasutaka Nakano (JPN)

13.30 Phenotyping lung disease using magnetic resonance imaging (MRI), Yoshiharu Ohno (JPN) 14.00 Phenotyping lung disease using positron emission tomography (PET), Kenneth Tsang (HKG) 14.30 Phenotyping lung disease using optical coherence tomography (OCT), Harvey O. Coxson (CAN)

15.15 – 17.15 Pediatric Assembly Symposia. OSAS in Children Chairs: Albert Li (HKG), Darmawan (INA) 15.15 Burden of OSAS in children in Asia Pacific Region, Albert Li (HKG) 15.45 Can we apply personalized medicine to the management of childhood obstructive sleep apnea: newer treatment modalities, Carole L. Marcus (USA) 16.15 What happens to a child with untreated obstructive sleep apnea? Rosemary S. Horne (AUS) 16.45 PSG should be carried out before adenotonsillecto my for childhood OSA – a debate, Bambang Supriyatno (INA)

08.00 – 09.30 Lung Structure and Function Congress Symposia. Lung Function in Various Disease Chairs: Takehiko Hiramoto (JPN), M Amin (INA) 08.00 Role of spirometric full flow-volume curve in searching causes of dyspnea, Le Thi Tuyet Lan (VNM) 08.30 Measuring lung function in elderly, Takehiko Hiramoto (JPN) 09.00 Lung function in various disease, Paul Enright (USA)

13.00 – 15.00 Environmental and Occupational Health and Epidemiology Assembly Symposia. Trends in Occupational Lung Diseases in Developing and Developed Nations Chairs: Soon-Hee Jung (KOR), Mukhtar Ikhsan (INA) 13.00 Pathology of asbestos-related diseases, Andrew Churg (CAN) 13.30 Mechanisms for asbestos-related diseases, Richard Lake (AUS) 14.00 Mesothelioma: diagnosis and management, Takashi Nakano (JPN) 14.30 Compensation for asbestos-related diseases in Korea: current situation, Soon-Hee Jung (JPN)

15.15 – 17.15 Environmental and Occupational Health and Epidemiology Congress Symposia. Respiratory Management in Natural Disaster Chairs : Winariani (INA), Bruce Robinson (AUS) 15.15 Potential carcinogenicity of man-made fibers in lung cancer, Thomas W Hesterberg (USA) 15.45 Respiratory management in natural disaster, Bruce Robinson (AUS) 16.15 Air pollution and respiratory diseases in the Asia-Pacific region, Masayuki Shima (JPN) 16.45 Smoking and lung-related disease: current data, Talant Sooronbaev (KGZ)

13.00 – 15.00 The Evolving Role of Real-Life Research in Respiratory Medicine (Respiratory Effectiveness Group) Chairs: Christine Jenkins (AUS), Ken Ohta (JPN) 13.00 Real Life studies - a poor relation or important partner to the respiratory RCT, J Christian Virchow (DEU) 13.40 The implications of real-life (comorbid conditions, inhaler technique, age and lifestyle factors) on asthma management: is there any evidence, David Price (AUS) 14.20 Leveraging datasets and insisting on quality, Tan Tze Lee (SIN)

15.00 – 17.00 Clinical Respiratory Medicine Assembly Symposia. Interesting Clinical Cases Unusual Cases of Clinocopath Correlation

Chairs: Philip Eng (SGP), Faisal Yusuf (INA)

08.00 Interesting clinical cases, Philips Eng (SGP) 08.50 Interesting clinical cases, David Lam (HKG)

Saturday, 15 November 2014

08.00 – 10.00 COPD Assembly Symposia. Redefining COPD Chairs: Masaharu Nishimura (JPN), M. Amin (INA) 08.00 COPD phenotyping, Jorgen Vestbo (DNK) 08.30 Assessment of biomarkers, tba 09.00 3D CT airway analysis, Masaharu Nishimura (JPN) 09.30 Assessment of quality of life in COPD, Paul Jones (GBR)

10.00 – 10.30 Presidential Lecture. Diversity and Heterogeneity in the Respiratory Problems in Asia Pacific: The Global Burden of Respiratory Disease Chairs: Faisal Yunus (INA) / Arth Nana Diversity and Heterogeneity of Respiratory Disease in Asia Pacific: The Step Forward, Norbert Berend (AUS)

10.45 – 11.30 Takeda Pharmaceuticals International. Lunch Symposia 12.00 – 13.00 Pfzer Corporation. Lunch Symposia.

13.00 – 13.30 Ann J Wookock Memorial Lecture. Chair : Michiaki Mishima (JPN)

13.30 – 14.00 Mishiyoshi Harasawa Memorial Lecture. Chair : Yoshinosuke Fukuchi (JPN)

14.00 – 16.00 Lung Infection Non TB Assembly Symposia. CAP in Asia Pacific Chairs: Jun-Hee Woo (KOR), M. Sardikin (INA) 14.00 CAP, Asia Pacific Guideline, Jun-Hee Woo (KOR) 14.40 How do we treat CAP and its complication, tba 15.20 Improving outcome of CAP, Ronald Grossman (CAN)

16.15 – 18.00 COPD Assembly Symposia. COPD: Progress on the Management Chairs: Muljadi (INA) 16.15 Should we treat earlier stage of COPD? tba 16.40 Exacerbation in COPD: the new concept, Alejandro Casas Herrera 17.05 Comorbidities in COPD, Suzanne Hurd 17.30 Rehabilitation in COPD, tba

08.00 – 10.00 Interstitial Lung Disease Congress Symposia. Comorbidity in IPF Chairs: Yasuhiro Kondo (JPN), Dianiati Sutoyo (INA) 08.00 Infection in Interstitial lung Disease, Sita Andarini (INA) 08.30 Pathogenesis of IPF, Emphysema, and the Combined, Masahito Ebina (JPN) 09.00 Acute exacerbation of IPF, Yasuhiro Kondo (JPN) 09.30 Comorbidity in IPF, Arata Azuma (JPN)

11.00 – 11.30 Covidien Private Limited. Pre-Lunch Symposia. 12.00 – 13.00 AstraZeneca. Lunch Symposia. Chair: M. Amin (INA) 12.00 New paradigm: combination therapy as maintenance and reliever in asthma, Peter J Barnes (GBR) 12.20 Do all ICS/LABA provide equal exacerbation protection and safety benefits to COPD patient? Christine R Jenkins (AUS) 12.40 Discussion

14.00 – 16.00 Interstitial Lung Disease Assembly Symposia. Idiopathic Pulmonary Fibrosis (IPF): Novel Approach Chairs: Masahito Ebina (JPN), Kang Jian (CHN)

14.00 Current guidelines of ILD, Yoshikazu Inoue (JPN) 14.30 Potential Pitfalls of IPF diagnosis, Ganesh Raghu (USA) 15.00 Treatment of IPF and acute exacerbations: lesson from Japan, Arata Azuma (JPN) 15.30 IPF in China: diagnosis and treatment approach, Kang Jian (CHN)

16.15 – 17.45 Interstitial Lung Disease Assembly Symposia. IPF: Next Target Chairs: Masahito Ebina (JPN), Arata Azuma (JPN)

16.15 Smoking-related interstitial lung disease, Andrew Churg (CAN) 16.40 IPF: What we have learned, Toshihiro Nukiwa (JPN) 17.05 Update on the treatment of IPF, Ganesh Raghu (USA) 17.30 IPF: the future ahead, Masahito Ebina (JPN)

08.00 – 10.00 Critical Care Assembly Symposia. Hot Issues in ARDS

Chairs: Yoshiki Ishii (JPN), Prasenohadi (INA)

08.00 Subphenotype in ARDS and biomarkers, tba 08.30 Exploring the heterogeneity of effects of corticosteroids on ARDS, Sheng-Yuan Ruan (TWN) 09.00 Is acute exacerbation of pulmonary fibrosis ARDS, Yoshiki Ishii (JPN) 09.30 Noninvasive ventilation: the horizon is expanding, Nicholas Hill (USA)

11.00 – 11.30 Boehringer Ingelheim. Pre-Lunch Symposia Chair: Hadiarto Man (INA) Unmet Needs in Asthma; Future Treatment Options, Mario Castro

12.00 – 13.00 Zambon. Lunch Symposia Small Airways in Asthma : Time to Rethink Chair: Budi Antariksa (INA) 12.00 New paradigm: combination therapy as maintenance and reliever in asthma, Peter J Barnes (GBR) 12.20 Do all ICS/LABA provide equal exacerbation protection and safety benefits to COPD patient? Christine R Jenkins (AUS) 12.40 Discussion

14.00 – 16.00 Pulmonary Circulation Assembly Symposia. What`s New in Pulmonary Hypertension Chairs: Kimura Hiroshi (JPN), Triya Damayanti (INA)

14.00 What's new in pulmonary hypertension, Hiroshi Kimura (JPN) 14.30 Pulmonary hypertension associated with pulmonary disease/hypoxia, Masayuki Hanaoka (JPN) 15.00 Recent strategies for chronic thromboembolic pulmonary hypertension, Nobuhiro Tanabe(JPN) 15.30 Pulmonary hypertension, are we making progress? Nicolas Hill (USA)

16.15 – 18.00 Lung Infection Congress Symposia. TB Risk Factors and Intervention Chairs : Francis Drobniewski (ITA), Laksmi Wulandari (INA)

16.15 Tuberculosis, tobacco and smoking cessation, Asif M Mahmud (BGD) 16.40 TB and Diabetes control, Roslina Manap (MAL) 17.05 TB-HIV, Charles Yu (PHL) 17.30 TB control and MDR-XDR prevention in India, Vijayan V.K. (IND)

08.00 – 10.00 Bronchoscopy and Interventional Technique Assembly Symposia. Novel Bronchoscopy and Interventional Technique Chairs: Takashi Ishida (JPN), Oea Khairsyaf (INA)

08.00 Latest update on interventional bronchoscopy, Teruomi Miyazawa (JPN) 08.20 Navigational bronchoschopy: the advances, Takashi Ishida (JPN) 08.40 Bronchial thermoplasty in the management airway obstruction, Michael Weschler (USA) 09.00 Management of endobronchial tuberculosis, Wahju Aniwidyaningsih (INA) 09.20 Airway stenting: the future and drawback, Hervey Dutau (FRA)

14.00 – 16.00 Bronchoscopy and Interventional Technique Congress Symposia. Pleural Disease Chairs: Lee Pyng (SGP), Boedi Swidarmoko (INA) 14.00 Update in pleural disease, Richard Light (USA) 14.20 Managing tuberculosis pleural disease, Menaldi Rasmin (INA) 14.40 Advances in pneumothorax management: COPD vs TB pneumothorax, Lee Pyng (SIN))

15.00 Malignant pleural effusion and mesothelioma, Gary Lee (AUS) 15.20 Pleural disease for malignant pleural effusion, Rodriguez Panadero (ESP)

16.15 – 17.00 Lung Infection Non TB Congress Symposia. Difficult Respiratory Infection Chairs: Isnu Pradjoko (INA), Teguh Sartono (INA)

16.15 Managing respiratory infection in ICU, Curtis Sessler 16.45 Preventing chronic lung infections: lessons from cystic fibrosis, Thomas Ferkol (ATS) 17.15 Pulmonary infection in chronic respiratory disease, Ronald Grossman (CAN)

08.00 – 10.00 Lung Cancer Congress Symposia. Lung Cancer in Asia Pacific Chairs: Chunxue Bai (CHN), Anwar Jusuf (INA) 08.00 Genetic heterogeneity in lung cancer: diversity in Asia-Pacific region, Chunxue Bai (CHN) 08.30 Recent advances of molecular diagnosis for cancer, Eiso Hiyama (JPN) 09.00 Lung cancer screening program: any good news? Kazuma Kishi (JPN) 09.30 Lung cancer in Indonesia and the AP region: shifting disease paradigm, Elisna Syahruddin (INA)

14.00 – 16.00 Clinical Respiratory Medicine Assembly Symposia. Smoking Cessation Chairs: Jennifer Mendoza (PHL), Jamal Zaini (INA)

14.00 Smoking related disease: current data, Judith Mackay (HKG) 14.20 Guidelines of Smoking Cessation in Japan, Hiroshi Kawane (JPN) 15.00 Smoking and lung disease in children, Jeniffer Mendoza (PHL) 15.30 e-cigarettes, Dean Schraufnaugel (USA)

16.15 – 17.15 Lung Cancer Congress Symposia. What’s New in Small Cell Lung Cancer (SCLC) and Neuroendocrine Tumor of the Lung Chairs: Kazuhisa Takahashi (JPN), Sita Andarini (INA) 16.15 Molecular signature of SCLC, David Lam (HKG) 16.35 Neuroendocrine tumor of the lung, Chong-Kin Liam (MAL) 16.55 Any good news for SCLC? Chunxue Bai (CHN)

08.00 – 10.00 Clinical Respiratory Medicine Assembly Symposia. Interesting Clinical Cases. Unusual Cases of Clinocopath Correlation Chairs: Ratnawati (INA), Sutji Mariono (INA)

08.00 Interesting clinical cases, Philips Eng (SIN) 08.50 Interesting clinical cases, Low Su Ying (SIN)

14.00 – 15.00 Distinguished Young Investigator Session

14.00 ERS Young investigator TBC session title 14.30 ERS Young investigator TBC session title

16.15 – 17.05 Distinguished Young Investigator Session

16.15 ATS young investigator - session title TBC 16.40 ATS young investigator - session title TBC

PROGRAM DETAILS I Sunday, 16 November 2014 08.00 – 10.00 Lung Infection TB Assembly Symposia. ISTC to Ensure Quality of Care Chairs: Charles Yu (PHL), Reviono (INA) 08.00 International Standard of TB Care, Philip Hopewell (USA) 08.30 TB in Asia Pacific: the challenges, Charles Yu (PHL) 09.00 Second line anti TB drugs: Mechanism of action and rational for use, Chen Yuan Chiang (CHN) 09.30 Evolution and transmission of drug-resistant TB, Francis Drobniewski (GBR)

10.00 – 12.00 Lung Infection Non TB Assembly Symposia. Viral Pneumonia Chairs: Matsuyama Shutoku (JPN), Priyanti Soepandi (INA) 10.00 SARS outbreak: what we have learned, David Hui (HKG) 10.30 H5N1 pneumonia in Indonesia: current position and strategies, Tjandra Yoga Aditama (INA) 11.00 MERS in Saudi Arabia, Abdullah Abdul Rahman Al Shimemeri (SAU) 11.30 Respiratory viral outbreak: future ahead, Matsuyama Shutoku (JPN)

10.00 – 12.00 Asthma Assembly Symposia. What is the Pipelines in Asthma Therapy Chairs: Christopher KW Lai (HKG), Suradi (INA) 10.00 Asthma in Asia Pacific: the burden, Christopher KW Lai (HKG) 10.30 LABA, LAMA and others bronchodilators in asthma treatments, Teresita de Guia (PHL) 11.00 Place of biological therapies, Gary Anderson (AUS) 11.30 New anti-inflammatory treatments in asthma, Christine Jenkins (AUS)

08.00 – 08.45 Respiratory Services Towards : Patient Safety and Medical Ethics Chairs : Arifin Nawas (INA), Prasenohadi (INA) 08.00 – 08.20 Patient safety and medical ethics, tba 08.20 – 08.40 Medical ethics, tba 08.00 – 10.00 Respiratory Organization Workshop 12.00 Closing Ceremony & Lunch

CONGRESS VENUE MAP

FORM

Hotel Name Grade and Location Room Type Rate

Bali Nusa Dua Hotel 5 Nusa Dua : USD 160.00

Nusa Dua Beach Hotel & Spa 5 Nusa Dua Deluxe Room : USD 185.00 Premier Room : USD 205.00 Palace Club Room : USD 275.00

Grand Hyatt 5 Nusa Dua : USD 220.00

Melia Bali 5 Nusa Dua

Deluxe Room : USD 168.00 Premium Room : USD 168.00 Junior Suite : USD 200.00 Duplex : USD 205.00 Lagoon Access Suite : USD 240.00

Sofitel Bali 5 Nusa Dua : USD 235.00

The Laguna Resort 5 Nusa Dua Deluxe Garden View : USD 230.00 Deluxe Lagoon View : USD 250.00 Executive Suite : USD 275.00

The Mulia Resort 5 Nusa Dua Mulia Grandeur : USD 267 Mulia Grandeur Deluxe : USD 291

Westin Hotel & Resort 5 Nusa Dua : USD 265.00

Bali Tropic Resort & Spa

4 Nusa Dua : USD 125.00

Courtyard Marriot

4 Nusa Dua

Deluxe Garden View : USD 150.00 Deluxe Pool View : USD 165.00 Premium Deluxe : USD 175.00

Mercure Hotel Nusa Dua 4 Nusa Dua USD 80.00

Novotel Bali Nusa Dua 4 Nusa Dua Deluxe Room : USD 150.00 One Bedroom Suite : USD 190.00

Santika Siligita 4 Nusa Dua : USD 100.00

Grand Whiz Hotel 4 Nusa Dua : USD 95.00

Ibis Styles Tanjung Benoa 3 Benoa : USD 80.00

* Accommodation reservation is available through www.apsr2014.org. First come first served base. * Please register early at special rate to get available room * All listed hotel will be provided by scheduled shuttle service to convention center PT. CERIA TOURS AND TRAVEL (Licence: 109/D.2/BPU/VI/89) Jl. By Pass Ngurai Rai, Pertokoan Citra Bali No. 32, Tuban – Kuta – Bali Phone: +62-361-704 300 I Fax: +62-361-895 7744 Contact Person: Ms. Chony Email: info@baliceriatours.com

Information Hotel

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Workshops in Conjunction with APSR 2014 (Thu 13 Nov 2014 @ BNDCC Bali) ALL Students Only

Postgraduate Course: Updates on Lung Cancer (ESAP Seminar) USD $100 USD $50

Postgraduate Course: Respiratory Neurobiology and Sleep USD $100 USD $75

Postgraduate Course: Pathogenesis of COPD and Disease Phenothype of COPD USD $100 USD $75

Postgraduate Course: MDR-TB (Half-Day) USD $100 USD $75

Postgraduate Course: Lung Infection (Half-Day) USD $100 USD $75

Workshop on Basic and Advances of Lung Function USD $150 USD $75

(For Pulmonologists Only) Workshop on Bronchoscopy 1: Management of Airway Stenosis and Corpus Alienum

USD $350 Only

(For Pulmonologists Only) Workshop on Bronchoscopy 2: Peripheral Lung Nodules and Interventional Management on Asthma

USD $350 Only

(For Pulmonologists Only) Workshop on Pleural Disease and Thoracoscopy USD $350 Only

Workshop on Lung Mechanical Ventilation USD $350 USD $150

Congress Gala Dinner & Cultural Night on Saturday 15 November 2014

Per Person Attendance and Dinner for this session USD $100.00 x Pax

Accompanying Person at APSR 2014 Accompanying Person's Access to Trade Exhibition and General Areas Only

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SIN$400.00

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APSR 2014 Secretariat Head Office Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia,

Persahabatan Hospital, Jalan Persahabatan Raya No.1, Rawamangun, Jakarta 13230, Indonesia Phone : +62-21-4705684 ; +62-21-70726355 I Fax : +62-21-47869389, +62-21-4705684 I Email: apsrindonesia@gmail.com

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