GEI Workshop
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Gene-Environment Interplay in
Common Complex Diseases:
Forging an Integrative Model
Natcher Conference Center, NIH
Campus
Bethesda, Maryland
January 25, 2010
Background: The longstanding nature-versus-nurture
debate has been turned on its head. Scientists now
recognize that it is not a question of genes or
environment, but rather, that genes and environment
are inextricably intertwined throughout development to
explain virtually every observable trait. To gain a more
detailed understanding of the impact of genetic and
environmental factors on health and disease, the NIH
Genes, Environment and Health Initiative (GEI)
(www.gei.nih.gov) was launched in 2006. The GEI
program supports genetic analyses and the
development of technologies to measure environmental
exposures through its Genetics Program
(www.gei.nih.gov/genetics/) and Exposure Biology
Program (EBP; www.gei.nih.gov/exposurebiology
/index.asp), respectively.
Goal: The goal of the workshop was to engage the
scientific community in discussing and conceptualizing
a truly transdisciplinary model of geneenvironment
research that fully integrates the genetics and
environment sides of the geneenvironment equation.
The workshop featured presentations to showcase the
stateofthescience and focused discussions to
articulate future needs and directions in research and
training on gene-environment interplay related to
health.
This workshop was sponsored by the National
Institutes of Health (NIH) Office of Behavioral and
Social Sciences Research (OBSSR) in conjunction with
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the NIH Genes, Environment and Health Initiative.
Planning Committee:
Tanya Agurs-Collins, Ph.D. (NCI)
Audie Atienza, Ph.D. (NCI)
David Balshaw, Ph.D. (NIEHS)
Ebony Bookman, Ph.D. (NHGRI)
Jennifer Collins (NIEHS)
Elizabeth Gillanders, Ph.D. (NCI)
Emily Harris, Ph.D. (NHGRI)Kimberly McAllister, Ph.D. (NIEHS)
Paige McDonald, Ph.D. (NCI)
Dina Paltoo, Ph.D., M.P.H. (NHLBI)
Sonja Preston, M.S.W. (OBSSR)
Jill Reedy, Ph.D. (NCI)
Joni Rutter, Ph.D. (NIDA)
Daniel Shaughnessy, Ph.D. (NIEHS)
Kay Wanke, Ph.D., M.P.H. (OBSSR)
Agenda
10:00
a.m.Registration
8:30
a.m.Welcome and Introduction
Deborah H. Olster, PhD, Deputy Director,
OBSSR
Eric Green, MD, PhD, Director, NHGRI
Linda S. Birnbaum, PhD, DABT, ATS,
Director, NIEHS
9:00a.m.
GxE Interplay: The perspective from
the genetics side
GWAS
Perspective
Laura Bierut, MD,
Washington University in
St. Louis
Statistical
Genetics
Peter Kraft, PhD, Harvard
School of Public Health
Epigenetics Margaret Danielle Fallin,
PhD, Johns Hopkins
University
10:00
a.m.Break
10:15
a.m.GxE Interplay: The perspective from
the environment side
Molecular
Exposures
Frederica P. Perera, MPH,
DrPH, Columbia
University
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Developmental
Psychology
Eric Turkheimer, PhD,
University of Virginia
Social Science Jason D. Boardman, PhD,
University of Colorado at
Boulder
11:30
a.m.Overview of afternoon and goals for
breakout sessions
12:00
p.m.Lunch (on your own)
1:00
p.m.Breakout Group Discussions in Natcher
Meeting Rooms
Breakout Group Leaders
Eric Boerwinkle, PhD, The University of
Texas
Neil E. Caporaso, MD, National Cancer
Institute
Nancy J. Cox, PhD, The Universi ty of
ChicagoPriya Duggal, PhD, MPH, Johns Hopkins
University
Lynn R. Goldman, MD, MPH, Johns
Hopkins University
Megan R. Gunnar, PhD, Universi ty of
Minnesota
Irva Hertz-Picciotto, PhD, MPH, University
of California, Davis
Kristen C. Jacobs0n, PhD, The University
of Chicago
Will iam L. Lowe, Jr., MD, Northwestern
UniversityMary L. Marazita, PhD, FACMG,
University of Pi ttsburgh
Stephen M. Rappaport, PhD, Universi ty of
California, Berkeley
Stephen J. Suomi, PhD, Eunice Kennedy
Shriver National Institute of Child Health
and
Human Development
3:15
p.m.Break
3:30
p.m.Reports from the Break Out Group
Leaders (10 minute presentations)
4:30
p.m.Panel Discussion and Q&A
5:00
p.m.Close
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Genes, Environment and Health Initiative, National Institutes of Health, Bethesda, Maryland 20892
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Workshop http://www.gei.nih.gov/genetics/meetings/retreat/gei_retreat_02
6/10/2011