Gastroesophageal reflux in children
description
Transcript of Gastroesophageal reflux in children
Gastroesophageal reflux in children
浙江大学医学院附属儿童医院
江米足
Definition of GER or GERD GER: means involuntary passage of gastric
contents into the esophagus and is often physiological.
GERD: means symptoms or complications associated with pathological GER.
Hassall E. Arch Dis Child 2005
Prevalence USA:
3-9 y:566 cases, 1.8% 10-17 y:615 cases, 3.5% Adults ( > 18 y):22%
The prevalence of GERD slowly increases with age during childhood and becomes quite frequent among young adults.
Nelson SP, et al. Arch Pediatr Adolesc Med 2000
Prevalence Australia:863 infants
3-4m(41%) 13-14m( < 5%)
India:602 infants 1-6m(55%) 7-12m(15%) 12-24m(10%)
Italy:2642 infants 0-12m (12%)
Martin AJ, et al. Pediatrics 2002
Campanozzi A et al. Pediatrics 2009
De S, et al. Trop Gastroenterol 2001
Prevalence GER is frequently seen in early infancy and it
almost disappears by one year of age. Persistence or appearance of regurgitation
beyond 18 months of age is suggestive of pathological condition.
The prevalence of GERD in infancy is 5%-9% of all infants with regurgitation.
Poddar U. Indian Pediatr 2013
Risk factors of GER Poor function of LES (pressure and length) Esophageal dysmotility resulting in reduced cl
earance Abnormal anatomy-including congenital malf
ormation (short intra-abdominal esophagus) or acquired disease (esophageal atresia repair)
Higher intra-gastric pressure and delayed gastric emptying
Liu XL, et al. Hong Kong Med J 2012
Mechanisms Closing mechanisms
The diaphragm creates a pinch cork action and functions to increase the pressure
The intra-abdominal portion of the esophagus The angle of His between the stomach and the eso
phagus Opening mechanisms
Increased intra-abdominal pressure (from abdominal tumours, coughing, and constipation) increases intra-gastric pressure
Liu XL, et al. Hong Kong Med J 2012
TLESR
Omari TI, et al. Gut 2002
TLESR is the predominant mechanism of GER triggering, accounting for 50-100% (median 91.5%) of all GER episodes.
Clinical symptoms of GER Clinical features of GER vary in children of different ag
es. Typical symptoms
Regurgitation Vomiting Heartburn Chest pain
Atypical symptoms Feeding difficulties/anorexia Failure to thrive Postural defect Stridor Chronic cough Laryngitis, otitis Asthma sinusitis Martigne L, et al. Eur J Pediatr 2012
Yuksel ES, et al. Eur J Med Sci 2010
Presenting symptoms Regurgitation or vomiting
Healthy: no failure to thrive or other associated symptoms
Infants with GERD Growth failure or indirect symptoms of pain due to esoph
agitis like irritability, feeding difficulty, sleeping difficulties, crying episodes, anemia
Rarely apnea or ALTE Chronic respiratory diseases and upper airway problems li
ke sinusitis, otitis media, laryngitis, dental erosion In children and adolescents, symptoms and compli
cations of GERD are heartburn or substernal pain
Diagnostic test Esophageal pH monitoring Multichannel intraluminal impedance (MII) measurem
ent High resolution manometry (HRM) Endoscopy Confocal laser endomicroscopy Barium UGI series Nuclear scintigraphy GER questionnaire Rome III criteria
Esophageal pH monitoring To establish the presence of acidic reflux (pH<
4) To quantify reflux in patients with mainly extr
a-esophageal symptoms To assess the efficacy of medical therapy To measure GER in patients not responding to
antireflux treatment and in research
24 hr ambularoty pH-metry
Parameters of pH monitoring Percent total time with a pH<4.0 (reflux index,
RI) Percent upright time with a pH<4.0 Percent supine time with a pH<4.0 Number of reflux episodes Number of reflux episodes lasting≥5 min Longest reflux episode (min) The scoring system
Boix-Ochoa score Demeester score
Diagnostic criteria of pathological GER RI is the main parameter in diagnosing GERD. RI 10% ( <1 year ) , 5% ( >1 year ) RI 10% ( <1 year), 4.2% ( >1 year ) USA: RI≥12% (<1 year) ,≥ 6% (>1 year) RI>7% as abnormal, <3% as normal, 3-7% as indeterm
inate (ESPGHN, NASPGHN) Boix-Ochoa score >11.99 Demeester score >14.72
Van der Pol RJ, et al. J Pediatrics 2012Vandenplas Y, et al. J Pediatr Gastroenterol Nutr 2009Mattioli G, et al. Dig Dis Sci 2006Aggarwal S, et al.Trop Gastroenterol 2004Wenzl TG. J Pediatr Gastroenterol Nutr 2011
Esophageal pH monitoring Advantages
Be done in any age Be relatively non-invasive
Disadvantage Does not measure non-acid or weakly acidic
reflux
Multichannel intraluminal-impedance (MII) measurement To detect the change in electrical
resistance (or impedance) when substances pass through the esophagus using a series of impedance sensors lying 1 cm apart on a probe
Impedance is inversely proportional to electrical conductivity
Since the conductivity of liquid (high) and air (low) is different, MII can easily differentiate liquid from gas reflux
Wenzl TG, et al. J Pediatr Gastroenterol Nutr 2012
Wenzl TG, et al. J Pediatr Gastroenterol Nutr 2012
Advantages of MII-pH monitoring Be superior to pH-study alone for
evaluation of GER-related symptom association
Picking up acid, non-acid or weakly acid reflux,
the direction of reflux To distinguish between liquid, solid and
gas reflux in all age groups
Limitations of MII-pH study High cost Limited availability Limited therapeutic implications (clinical
relevance of measuring non-acidic reflux remains doubtful)
The lack of evidence-based parameters for assessment of GER
High resolution manometry (HRM) Conventional manometry assemblies detect pressure
using a catheter with several water-perfused sideholes by gaps between the pressure sensors which are several centimeters long.
HRM catheters are equipped with intraluminal pressure transducers
Simultaneously measure from hypopharynx to stomach
Assign color to specific pressure levels which are than presented in a spatiotemporal plot
Pressure topography plots are more intuitive and easier learned by clinicians
Kessing BF, et al. Curr Gastroenterol Rep 2012
Clinical application of HRM HRM is superior to other diagnostic tools for th
e evaluation of achalasia and contributes to a more specific classification of esophageal disorders in patients with non-obstructive dysphagia
Kessing BF, et al. Curr Gastroenterol Rep 2012
Endoscopy Upper gastrointestinal endoscopy is the best method
of detecting esophagitis as a consequence of GERD. Normal endoscopy (found in 60%-80% cases of GERD i
n children) does not rule out GERD and this type of GERD is called Non-erosive reflux disease (NERD).
Endoscopy needs to be combined with a biopsy to increase the diagnostic yield (especially in NERD) and to rule out other causes of esophagitis (like eosinophilic esophagitis, Crohn’s disease).
Indications of endoscopy Persistence of symptoms despite therapy Dysphagia or odynophagia Evidence of GI bleeding or iron deficiency ane
mia Stricture or ulcer on barium study Long duration GERD to detect Barrett’s esop
hagus.
Advantages of endoscopy Gives a direct information about the presence
and severity of esophagitis Detects complications like ulcer, stricture, Bar
rett’s esophagus Documents healing of erosive esophagitis afte
r therapy. Exclude other causes of esophagits by endosc
opic esophageal biopsy.
Los Angeles classification A One or more mucosal breaks, each ≤ 5
mm in length B At least one mucosal break > 5 mm
long, but not continuous between the tops of adjacent mucosal folds
C At least one mucosal break that is continuous between the tops of adjacent mucosal folds, but which is not circumferential (< 75% of luminal circumference)
D Mucosal break that involves at least 75% of the luminal circumference
Kamal A, et al. Best Practice Res Clin Gastroenterol 2010
The evidence of histology Histology is more sensitive than endoscopy in
the early stage (non-erosive stage). Erosive esophagitis is the most definite eviden
ce of GERD on endoscopy. Biopsy (2 cm proximal to gastroesophageal ju
nction) helps to establish the diagnosis of GERD if there is no erosion or mucosal break on endoscopy.
Esophageal histological features of GERD Basal zone hyperplasia (>20% of total thickness) Elongation of papillae (>50% of total thickness) Infiltration with neutrophils or eosinophils (<15/high p
ower field) The presence of dilated intercellular spaces Growing of blood vessels in papilla
Histological changes are neither sensitive nor specific for reflux disease in NERD cases and should not be used alone to diagnose or exclude GERD
Poddar U. Indian Pediatr 2013
Tobey NA, et al. Gastroenterology 1996
Boccia G, et al. Am J Gastroenterol 2007
Vandenplas Y, et al. J Pediatr Gastroenterol Nutr 2009
Barium UGI series Be useful to detect anatomical anomalies such
as the angle of His, esophageal dysmotility, mucosal irregularity, stricture, and hiatus hernia, but not useful in diagnosing GERD.
The sensitivity and specificity to diagnose GERD is less than 50%.
Cannot differentiate physiological from pathological reflux.
Most useful in ruling out underlying obstruction such as that due to achalasia
Nuclear scintigraphy Be a non-invasive test but has poor
sensitivity and specificity. To confirm silent aspiration in patients
with recurrent pneumonia due to aspiration of gastric contents.
Be a useful tool in evaluation of delayed gastric emptying
Not recommended for the routine evaluation of pediatric patients with suspected GERD.
Infant GER questionnaire (I-GERQ)
Orenstein SR, et al. Clin Pediatr 1996
I-GERQ Maximum total score:25 Score > 7, for diagnosing GERD in infants
Sensitivity 74% Specificity 94%
Can be used to segregate those infants who needs empirical therapy or further investigation because of its simplicity (take just 20 minutes to complete) and reproducibility.
Rome III criteria Must include all of the following in otherwise h
ealthy infants 3 weeks to 12 months of age Regurgitation 2 or more times per day for 3 or
more weeks No retching, hematemesis, aspiration, apnea, f
ailure to thrive, feeding or swallowing difficulties, or abnormal posturing
Diagnostic test When symptoms are not classical and in cases with co
mplicated GERD Endoscopy,pH study, barium upper GI series
In a patient with classical symptoms of GERD No need to confirm the presence of GER by pH study or by en
doscopy In patients with extra-esophageal symptoms like respi
ratory symptoms without any GER symptoms pH study is required to document reflux
When esophagitis is suspected (pain or blood loss) Upper gastrointestinal endoscopy with esophageal biopsy is r
ecommended Any suggestion of an anatomical abnormality like inte
stinal obstruction or dysphagia Barium upper GI series is indicated
Diagnostic approach to GERD There is no gold standard for the diagnosis
of GERD. The choice of investigation depends on the
clinical situation for which the investigation is asked for.
Management---GER in infants Counseling-the most important part
Explain the natural history of GER in infants to parents or care-givers
Other measures Feeding advice
Avoid overfeeding, forceful feeding Try to give small but frequent feeds
positioning Prone position-not recommended (the risk of SIDS) Left lateral position (age>13m)-the best in preventing
reflux feed thickening
Adding rice, corn or potato starch decrease the number regurgitation of vomiting does not decreases the acid exposure of esophagus
Feed thickener has only cosmetic value but no therapeutic benefit.
Proton pump inhibitors (PPIs) PPIs are not recommended in this subset of pa
tient Only a few of the infants are likely to have acid-rela
ted cause for their symptoms The largest randomized, controlled trial in infants s
howed that for symptoms, presumably to be related to reflux disease, a PPI was not better than placebo.
Orenstein SR, et al. J Pediatr 2009
Management---GERD in children Besides medication, life-style modification in t
erms of weight reduction, avoiding caffeine, chocolate, abstinence from alcohol, tobacco helps in children.
Adolescents, like in adults, may benefit from the left lateral decubitus sleeping position with head-end elevation
Pharmacological therapy Acid suppressants
Histamin-2 receptor antagonists (H2RA) Ranitidine: 6-8mg/kg/day, bid or tid Famotidine:1mg/kg/day, bid
PPIs Omeprazole:0.7 to 3.5 mg/kg/day, qd
Neutralizing or surface protective agents (antacids or sucralfate)
Prokinetics
H2RA Rapid onset of action (in 30 min) Short acting (6 hr) acid suppressants used for on-demand therapy (SOS therapy) A lack of post-prandial acid suppressant effect Develop tachyphylaxis on long-term use (in 6
weeks) Cannot be used for long term therapy H2RA are less effective than PPI
PPIs Inhibit acid secretion by irreversibly blocking
Na+-K+-ATPase in the apical membrane of parietal cells
Be taken 30 min before breakfast as parietal cells get activated in response to a meal.
Require a higher per kilogram dose than adults to obtain a similar degree of acid suppression due to higher metabolism of the drug. Omeprazole, 2-2.5mg/kg/day Lansoprazole, 1.4mg/kg/day
Side effect of PPIs Mild side effects have been reported in up
to 14% of children Most common side effects
headache diarrhea constipation nausea
Prokinetics metoclopramide, domperidone, erythromycin,
baclofen or itopride in the management of GERD
prokinetics may be of some use is GERD with associated gastroparesis
Vandenplas Y, et al. J Pediatr Gastroenterol Nutr 2009Poddar U. Indian Pediatr 2013
Duration of medical therapy GERD needs profound acid suppression for a
longer duration of time PPI therapy is recommended for at least 12 weeks
and then to taper over 2 to 3 months as rebound hyperacidity after sudden stoppage of PPI
No symptomatic improvement in 4 weeks then the dose of PPI needs to be increased
A relapse on withdrawal of PPI, medication needs to be restarted
Frequent relapses or continuous symptoms are indications for prolonged PPI therapy or surgery
Repeat endoscopy to document healing is indicated at the end of 12 weeks course in erosive esophagitis
Prolonged PPI therapy (median 3 years and up to 12 years) is safe
Full healing dose is superior to half dose in PPI maintenance therapy
Surgery Nissen fundoplication (open or laparoscopic) may be
of benefit in children with confirmed GERD Who have failed optimal medical therapy Who are dependent on medical therapy for a long time Who are significantly noncompliant to medical therapy Who have life threatening complication of GERD
Point: who need surgery most, develop surgery related complications and surgical failure most
Fundoplication in early infancy has a higher failure rate than in late childhood
Hassall E. Arch Dis Child 2005
Vandenplas Y, et al. J Pediatr Gastroenterol Nutr 2009
Poddar U. Indian Pediatr 2013
Conclusion GER is common in infants but GERD is not so common in early chi
ldhood Most infants have physiological reflux and need minimal interven
tion as their symptoms resolve by 18 months of age There is no gold standard diagnostic test for GERD and investigat
ion should be tailored to the clinical concern for a given child For extraesophageal manifestations, pH-metry with or without impe
dance is the best investigations For esophagitis, endoscopy is the best investigations
Empirical PPI therapy for 4 weeks is justified in older children and adolescents with classical symptoms
Medical therapy with PPI is very effective and safe. Surgical therapy is not a panacea as it carries significant morbidi
ty and often fails in those who need it most.