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Transcript of Free Radicals in the Context of Ayurvedic Rejuvenative Therapies Presented by Ingrid Naiman for...
Free Radicals in the Context Free Radicals in the Context of Ayurvedic Rejuvenative of Ayurvedic Rejuvenative
Therapies Therapies
Presented by Ingrid Naiman Presented by Ingrid Naiman forfor
AAPNA on 10 March 2013AAPNA on 10 March 2013
Copyright by Dr. Ingrid Naiman 2013 Copyright by Dr. Ingrid Naiman 2013
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Kaya KalpaKaya Kalpa
Curious about Alchemy and Curious about Alchemy and Rasayana HerbsRasayana Herbs
Fukushima RadiationFukushima Radiation Deep Concern for HumanityDeep Concern for Humanity Many Experiments & Many Experiments &
Attempts to Apply TheoriesAttempts to Apply Theories
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Free Radical TheoryFree Radical Theory
One Attempt to Explain the Cause of AgingOne Attempt to Explain the Cause of Aging DefinitionDefinition
Atom or molecule that has an unpaired Atom or molecule that has an unpaired electron in the outer orbitelectron in the outer orbit
ProblemsProblems Causes Oxidative Damage to TissuesCauses Oxidative Damage to Tissues Damages DNADamages DNA Kills White Blood CellsKills White Blood Cells
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Free Radicals Associated with Free Radicals Associated with Countless Degenerative Countless Degenerative
DiseasesDiseases Occurs mainly due to damage to lipid Occurs mainly due to damage to lipid
membranemembrane MutagenicMutagenic CarcinogenicCarcinogenic
Cancer, DNACancer, DNA Heart Attacks and Strokes, LDLHeart Attacks and Strokes, LDL Everything from wrinkles to Alzheimer’s Everything from wrinkles to Alzheimer’s
disease can be attributed to free radicals.disease can be attributed to free radicals.
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Causes of Free RadicalsCauses of Free Radicals Radiation, ionizing as well as electromagnetic fieldsRadiation, ionizing as well as electromagnetic fields Sunlight & ultraviolet light, especially UV-ASunlight & ultraviolet light, especially UV-A PollutionPollution Toxic Metals, PesticidesToxic Metals, Pesticides Chemicals & PharmaceuticalsChemicals & Pharmaceuticals OxidationOxidation
SmokingSmoking AlcoholAlcohol DietDiet
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Radiation DamageRadiation Damage
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The Vata ConnectionThe Vata Connection
Vata = Ether + AirVata = Ether + Air Associated with movement (kinetic energy)Associated with movement (kinetic energy)
Leads to changeLeads to change Can produce instabilityCan produce instability Causes sound & sensation Causes sound & sensation
Vata dosha is associated with agingVata dosha is associated with aging Vata destructiveness (wind) can cause:Vata destructiveness (wind) can cause:
Corruption of form & structureCorruption of form & structure Cell death resulting in die off debris & amaCell death resulting in die off debris & ama
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Free Radical TheoryFree Radical Theory
Attributed to Denham Harman, 1950sAttributed to Denham Harman, 1950s Lifespan is in inverse proportion to Lifespan is in inverse proportion to
metabolic ratemetabolic rate The metabolic rate is proportional to The metabolic rate is proportional to
oxygen consumptionoxygen consumption Oxygen free radicals lead to tissue Oxygen free radicals lead to tissue
damage and ultimately deathdamage and ultimately death
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OxidationOxidation
“ “85% of chronic and degenerative 85% of chronic and degenerative diseases are diseases are the results of oxidative damagethe results of oxidative damage.” .”
Yukie NiwaYukie Niwa
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StressStress
Increased intake of oxygen usually results Increased intake of oxygen usually results in more free radicalsin more free radicals Inflammatory reactionInflammatory reaction
CortisolCortisol Ashwagandha lowers cortisol output Ashwagandha lowers cortisol output
even when under stresseven when under stress
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The IronyThe Irony
Oxygen is necessary to life, but it is a Oxygen is necessary to life, but it is a highly toxic, mutagenic gashighly toxic, mutagenic gas
Oxygen is highly reactive and can cause Oxygen is highly reactive and can cause damage by producing reactive oxygen damage by producing reactive oxygen species (ROS)species (ROS)
Except for anaerobic species, most living Except for anaerobic species, most living organisms have an inherent capacity to organisms have an inherent capacity to produce antioxidantsproduce antioxidants
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Types of Free RadicalsTypes of Free Radicals
Superoxide anion: oxygen molecule with Superoxide anion: oxygen molecule with extra electron extra electron
Hydroxyl radicalHydroxyl radical highly reactive and damages DNA, highly reactive and damages DNA,
carbohydrates, lipids, and proteins carbohydrates, lipids, and proteins Singlet oxygen, catalyst to free radical Singlet oxygen, catalyst to free radical
formation) and damages LDL cholesterolformation) and damages LDL cholesterol
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Hydrogen PeroxideHydrogen Peroxide
Hydrogen peroxide is not a free radical but Hydrogen peroxide is not a free radical but is involved in the production of ROSis involved in the production of ROS
ROS which can persist indefinitelyROS which can persist indefinitely Highly mobileHighly mobile Penetrates the cell membrane from Penetrates the cell membrane from
outside to damage what is withinoutside to damage what is within Can form a dangerous hydroxyl free Can form a dangerous hydroxyl free
radical or be converted to water and radical or be converted to water and excreted harmlesslyexcreted harmlessly
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Lipid Peroxidation = Lipid Peroxidation = RancidityRancidity
Affects Mainly Polyunsaturated FatsAffects Mainly Polyunsaturated Fats Processed FoodsProcessed Foods
MeatMeat CheeseCheese
Unsaturated FatsUnsaturated Fats AvocadoesAvocadoes Canola oil, olive oil, peanut oil, sunflower oilCanola oil, olive oil, peanut oil, sunflower oil Macadamia nuts, cashews, almonds, pecansMacadamia nuts, cashews, almonds, pecans
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Fats in FoodFats in Food
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Herbs to Prevent RancidityHerbs to Prevent Rancidity
Turmeric, Turmeric, Curcuma longaCurcuma longa Chaparral, Chaparral, Larrea tridentataLarrea tridentata Rosemary Essential OilRosemary Essential Oil
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Hemolysis & Hemorrhage Hemolysis & Hemorrhage After Fukushima - After Fukushima -
ElectroperforationsElectroperforations
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GheeGhee
Significant improvement in lipid structures Significant improvement in lipid structures can be expected when patients switch can be expected when patients switch from vegetable oils to gheefrom vegetable oils to ghee
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Clinical ConsiderationsClinical Considerations
Difference between prevention and Difference between prevention and curecure ProtectiveProtective CorrectiveCorrective
ExamplesExamples ChyawanChyawan TapaswijiTapaswiji
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ChyawanprashChyawanprash
Ancient herbal jam used to prevent aging Ancient herbal jam used to prevent aging and promote longevity, variously and promote longevity, variously attributed to the sage Chywan or the attributed to the sage Chywan or the divine Ashwini brothers.divine Ashwini brothers. Amalaki fruitAmalaki fruit Herbs & spicesHerbs & spices Ghee & sesame oilGhee & sesame oil Astavarga herbsAstavarga herbs Purified alchemical substancesPurified alchemical substances
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Status of the PlasmaStatus of the Plasma
The plasma is straw-colored and needs to The plasma is straw-colored and needs to bebe in the correct pH rangein the correct pH range free of chemical & metallic toxins free of chemical & metallic toxins free of fungi, both yeast and moldfree of fungi, both yeast and mold free of radioactive particulates and EMF free of radioactive particulates and EMF
interferencesinterferences free of parasites, bacteria, and virusesfree of parasites, bacteria, and viruses
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Darkfield StudiesDarkfield Studies
Observe live bloodObserve live blood Can test almost any diet or protocol to Can test almost any diet or protocol to
determine the effect on the plasmadetermine the effect on the plasma ErythrocytesErythrocytes White blood cellsWhite blood cells PlateletsPlatelets Parasites, bacteria, spirochetes, fungi, metallic toxinsParasites, bacteria, spirochetes, fungi, metallic toxins AmaAma
Presence of free radicals can be inferredPresence of free radicals can be inferred
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Photoshop EnhancementPhotoshop Enhancement
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TourmalineTourmaline
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Evidence of Free RadicalsEvidence of Free Radicalsin Darkfieldin Darkfield
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Free Radical ScavengerFree Radical Scavenger
Sometimes referred to as an antioxidantSometimes referred to as an antioxidant Renders free radical stable by donating an Renders free radical stable by donating an
electronelectron May itself become a free radicalMay itself become a free radical May be removed by white blood cellsMay be removed by white blood cells May be eliminated from the bodyMay be eliminated from the body
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AntioxidantAntioxidant
Electron DonorElectron Donor Stabilizes the Free RadicalStabilizes the Free Radical Renders the Free Radical HarmlessRenders the Free Radical Harmless Manages these functions without sustaining Manages these functions without sustaining
damage or becoming itself a free radicaldamage or becoming itself a free radical
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Electron DonationElectron Donation
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Antioxidant HerbsAntioxidant Herbs
All Rasayana HerbsAll Rasayana Herbs ChyawanprashChyawanprash Especially high: TriphalaEspecially high: Triphala
Amalaki highestAmalaki highest HaritakiHaritaki BibhitakiBibhitaki
Arjuna, also radioprotectiveArjuna, also radioprotective Highest: Sangre de GradoHighest: Sangre de Grado
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Sangre de GradoSangre de GradoCroton lechleriCroton lechleri
Highest antioxidant rating of 3100 foods, Highest antioxidant rating of 3100 foods, herbs, and supplements testedherbs, and supplements tested mmol/100 grams = 2897.11 mmol/100 grams = 2897.11
4x higher than triphala4x higher than triphala
90% proanthocyanidins 90% proanthocyanidins Grows in the Rain ForestGrows in the Rain Forest
PeruPeru Main use is for bleeding and wound healingMain use is for bleeding and wound healing
Causes erythrocyte aggregationCauses erythrocyte aggregation
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Antioxidant Foods, Herbs, & Antioxidant Foods, Herbs, & Spices Spices
Cloves and CinnamonCloves and Cinnamon Fruits & VegetablesFruits & Vegetables
Especially those that are dark in colorEspecially those that are dark in color Acai and goji berriesAcai and goji berries Artichokes and beetsArtichokes and beets
Dark ChocolateDark Chocolate
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Myricetin AntioxidantMyricetin Antioxidant
Flavonoid found in berries and grapesFlavonoid found in berries and grapes WalnutsWalnuts OnionsOnions Bayberry barkBayberry bark Red wineRed wine Green teaGreen tea
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DNADNA
If the free radicalIf the free radical
reaction involvesreaction involves
strands of the strands of the DNA,DNA,
Serious Serious consequencesconsequences
can result.can result.
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Ayurvedic Herbs for DNA Ayurvedic Herbs for DNA ProtectionProtection
Ashwagandha, Ashwagandha, Withania somniferaWithania somnifera AntioxidantAntioxidant Supports normal cortisol levelsSupports normal cortisol levels Protects against lipid peroxidationProtects against lipid peroxidation
Bacopa, Bacopa, Bacopa Bacopa monnieri Promotes healthy functioning of Promotes healthy functioning of
neurotransmittersneurotransmitters Tulsi, Tulsi, Ocimum tenuiflorumOcimum tenuiflorum
Helps regulate blood sugar and cholesterolHelps regulate blood sugar and cholesterol
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Herbs that Repair DNAHerbs that Repair DNA
Sage (essential oil), Sage (essential oil), Salvia officinalisSalvia officinalis Anti-microbial, antifungal, antioxidant Anti-microbial, antifungal, antioxidant
Cat’s Claw, Cat’s Claw, Uncaria tomentosaUncaria tomentosa Improves functioning of DNA & RNAImproves functioning of DNA & RNA
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NeurogenesisNeurogenesis
Astragalus, Astragalus, AstragalusAstragalus membranaceusmembranaceus Extend life of telomeresExtend life of telomeres Improve how immune cells respond to virusesImprove how immune cells respond to viruses
Cat’s Claw, Cat’s Claw, Uncaria tomentosaUncaria tomentosa Chromosome repairChromosome repair
Ashwagandha, Ashwagandha, Withania somniferaWithania somnifera Helps regenerate damaged neurons in the brainHelps regenerate damaged neurons in the brain
Brain traumaBrain trauma Infection by parasites or spirochetesInfection by parasites or spirochetes
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Rasayanas and DhatusRasayanas and Dhatus
All rasayanas are antioxidantsAll rasayanas are antioxidants Promote resistance to diseasePromote resistance to disease Promote homeostasisPromote homeostasis Promote healthPromote health Promote optimal functioningPromote optimal functioning
All rasayanas promote longevityAll rasayanas promote longevity
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The DhatusThe Dhatus
All nutrients are first assimilated by rasa All nutrients are first assimilated by rasa dhatu and refined for use by rakta dhatu dhatu and refined for use by rakta dhatu and the other dhatus.and the other dhatus.
There is assimilation and waste at each There is assimilation and waste at each stage of tissue renewal.stage of tissue renewal.
Only what is used as a nutrient forms the Only what is used as a nutrient forms the dhatu.dhatu.
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Rasa DhatuRasa Dhatu
PlasmaPlasma Rasa dhatu is the sea in which blood Rasa dhatu is the sea in which blood
cells find nourishment.cells find nourishment. The quality of the fluid, safety of the The quality of the fluid, safety of the
fluid, and availability of high quality fluid, and availability of high quality nutrients determines the capacity to nutrients determines the capacity to sustain, regenerate, and rejuvenate all sustain, regenerate, and rejuvenate all other tissues of the body.other tissues of the body.
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Taste of Rasa DhatuTaste of Rasa Dhatu
Sweet Sweet NutritiousNutritious
SaltySalty MineralsMinerals
Pungent, Sour, Bitter, & Astringent in Pungent, Sour, Bitter, & Astringent in lesser amountslesser amounts
The nutrients needed are best supplied by The nutrients needed are best supplied by juicejuice
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Herbs for Rasa DhatuHerbs for Rasa Dhatu
Guduchi, Guduchi, Tinospora cordifoliaTinospora cordifolia Haritaki, Haritaki, Terminalia chebulaTerminalia chebula Shatavari, Shatavari, Asparagus racemosusAsparagus racemosus Jivanti, Jivanti, Leptadenia reticulataLeptadenia reticulata Punarnava, Punarnava, Boerhavia diffusaBoerhavia diffusa Bamboo manna Bamboo manna ShilajitShilajit
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Western Herbs for Rasa Western Herbs for Rasa DhatuDhatu
FluidsFluids WaterWater Herbal infusionsHerbal infusions Juices from fruits or vegetables, especially okraJuices from fruits or vegetables, especially okra
Herbs that are mucilaginous and demulcentHerbs that are mucilaginous and demulcent Herbs that are pH balancingHerbs that are pH balancing Herbs that are rich in trace minerals Herbs that are rich in trace minerals
Nettles (Nettles (Urtica dioicaUrtica dioica), sea vegetables, licorice ), sea vegetables, licorice ((Glycyrrhiza glabra), Glycyrrhiza glabra), burdock (burdock (Arctium lappaArctium lappa))
Herbs that aid digestionHerbs that aid digestion Lemon Balm (Lemon Balm (Melissa officinalisMelissa officinalis))
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BibliographyBibliography
Balch, James F., Balch, James F., The Super AntioxidantsThe Super Antioxidants, M. Evans & Company, Inc., , M. Evans & Company, Inc., New York, New York,
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Cox, Robert E., Cox, Robert E., The Elixir of ImmortalityThe Elixir of Immortality, Inner Traditions, Rochester, VT, , Inner Traditions, Rochester, VT, 2003.2003.
Halliwell, Barry & Gutteridge, John M.C., Halliwell, Barry & Gutteridge, John M.C., Free Radicals in Biology and Free Radicals in Biology and
MedicineMedicine, Fourth Edition, Oxford University Press, Oxford, 2010., Fourth Edition, Oxford University Press, Oxford, 2010.
Murthy, T. S. Ananta, Murthy, T. S. Ananta, TapaswijiTapaswiji, Sri Vishnu Ashram Trust Publication, , Sri Vishnu Ashram Trust Publication, Third Edition, Bangalore, 2003.Third Edition, Bangalore, 2003.
Schechter, Steven R., Schechter, Steven R., Fighting Radiation & Chemical Pollutants with Fighting Radiation & Chemical Pollutants with Foods, Herbs, & VitaminsFoods, Herbs, & Vitamins, Second Edition, Vitality Ink, Encinitas, CA., , Second Edition, Vitality Ink, Encinitas, CA., 1990.1990.
Winston, David & Maimes, Steven, Winston, David & Maimes, Steven, Adaptogens: Herbs for Strength, Adaptogens: Herbs for Strength, Stamina, and Stress ReliefStamina, and Stress Relief, Healing Arts Press, Rochster, VT, 2007., Healing Arts Press, Rochster, VT, 2007.
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Bibliography AyurvedaBibliography Ayurveda
Dash, Bhagwan, Dash, Bhagwan, Alchemy and Metallic Medicines in AyurvedaAlchemy and Metallic Medicines in Ayurveda, , Concept Publishing Company, New Delhi, 1996, Reprinted 2003.Concept Publishing Company, New Delhi, 1996, Reprinted 2003.
Frawley, David, Frawley, David, Soma in Yoga and AyurvedaSoma in Yoga and Ayurveda, Lotus Press, Twin Lakes, , Lotus Press, Twin Lakes, WI, 2012.WI, 2012.
Ojha, J.K., Ojha, J.K., Chyawanprash: From Vedic to Genomic EraChyawanprash: From Vedic to Genomic Era, Chaukhamba , Chaukhamba Sanskrit Pratishthan, Delhi, 2003.Sanskrit Pratishthan, Delhi, 2003.
Sharma, B. D. & Acharya Bal Krishnan, Sharma, B. D. & Acharya Bal Krishnan, Vitality Strengthening Vitality Strengthening Astavarga PlantsAstavarga Plants, Divya Yog Mandir Trust, Haridwar, 2005 (?), Divya Yog Mandir Trust, Haridwar, 2005 (?)
Sharma, Hari, MD, Sharma, Hari, MD, Freedom from DiseaseFreedom from Disease, Veda Publishing, Toronto, , Veda Publishing, Toronto, 1993.1993.
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Internet SourcesInternet Sources
Benzie, I.F.F. and Wachtel-Galor, S., editors, Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition, Boca Raton (FL): CRC Press, 2011.http://www.ncbi.nlm.nih.gov/books/NBK92763/
Carlsen, Monica H. et al, 2010
http://www.nutritionj.com/content/supplementary/1475-2891-9-3-s1.pdf
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