Fkumj Fisiologi Muskuloskeletal 2010
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PHYSIOLOGY ofMUSCULOSKELETAL
DR. Dr. H. Busjra M Nur MSc
Dept. Physiology FKUI / FKUMJ
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Sarcomeres
• Fundamental units of contraction
• Composed of thick (myosin) and thin (actin) myofilaments, joined by crossbridges.
• Contraction of individual sarcomeres results in shortening or force development of the whole muscle
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Types of Contraction (duration)
• Twitch
• Tetanic
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Types of Contraction (length)
• Isotonic
• Isometric
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• Motor unit
• Motor unit recruitment
• Reflexes in movement
• Gamma motor neuron
• Alfa motor neuron
• Muscle spindle
• Upper motor neuron
• Lower motor neuron
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Motor Unit
• for precision function
- eye muscles
- fingers muscles
• for strength
- legs muscles
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Motor unit recruitment
• All or none one motor unit
• Degree of strength degree of recruitment of motor units
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Reflexes in movement
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Upper motor neuronLower motor neuron
• Spastic paralysis / paresis
• Flaccid paralysis / paresis
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Crossbridge cycle (skeletal & cardiac)
• Membrane potential Ca ion release from sarcoplasmic reticulum
• Ca binds to Troponin C
• Energy from ATP cross bridge
• Ca taken away Cross bridge release (need ATP)
• No ATP rigor mortis
• Calcium antagonist in cardiac disease
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Neuromuscular Junction
• Motor neuron
• Terminal button
• Neuromyal cleft
• Motor end-plate
• Acetylcholine
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Neuromuscular Junction
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• Acetylcholin
- neurotransmitter
- ligand gated depolarization
- in the neuromuscular junction,
preganglionic and parasympathetic
neurons
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• Black widow spider venom
- deadly effect
- explosive release of ACh
- prolonged depolarixation
diaphragm fail to relax properly
respiratory failure
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• Clostridium botulinum toxin
- food poisoning
- lethal blow
- blocks release of ACh
- prevents muscle contraction
respiratory failure
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• Curare
- blocks ACh receptor sites
no mucle tone / contraction
respiratory failure
in surgery
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• Myasthenia gravis
- autoimmune disease
- antibodies inactivate ACh receptor sites
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• Organophosphates
- pesticides
- inhibit AChE (irreversible) ACh ↑
muscle failure to repolarize
respiratory failure
- antidote : atropine (ACh antagonist)
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• Neostigmine
- inhibit AChE (temporary)
- ↑ ACh in neuromuscular junction
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+
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Fatigue
• Muscle fatigue
- lactic acid
- depletion of energy
• Central fatigue
- psychological fatigue
• Neuromuscular fatigue
- inability to synthesize ACh rapidly
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Muscle fiber types
• Slow Oxidative Fiber (TYPE I)
• Fast Oxidative Fiber (TYPE IIa)
• Fast Glycolytic Fiber (TYPE IIb)
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Smooth Muscle
• Highly Economical in Its Energy Usage
• Cross bridge much more slowly
• Can maintain high level of force
• Can adapt to physiological needs: uterus muscle in pregnancy
• Composed of small, unstriated cells, contained contractile proteins
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Smooth Muscle
• Single-Unit
• Multi-Unit
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Single-Unit Smooth Muscle
• Gastrointestinal tract
• Blood vessels
• Respiratory tract
• Uterus
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Multi-Unit Smooth Muscle
• iris
• ciliary
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Cardiac muscle
• Small, striated cells
• Sarcomeres are similar to skeletal muscle
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Cardiac muscle
• Atrium
• Ventricle
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Bone
• Is living tissue
• A form of connective tissue
• Osteoblasts (“bone formers”) produce the organic matrix (collagen fibers)
• Osteoclasts (“bone breakers”)
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Physiology of Bone
• Matrix calcium deposit
• Osteoblast bone deposition
• Osteoklast bone resorption
• Continously undergous remodeling
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Calcium Deposit
• Calcium Input
• Vitamine D
• Vitamine D activation in the kidney
• Vitamine D in the liver
• Calsium absorption in the intestine
• Calsium reabsoption in renal tubulus
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Additional Factors
• Physical activity
• Hormone – estrogene
-- testosterone
-- growth hormone
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PTH (parathyroid hormone)
• Is essential for life
• ↑ Ca ions in the plasma
• ↑ reabsorption Ca ion in the kidney
• ↓ reabsorption of phosphate in the kidney
• Via vit D ↑ Ca absorption in intestine
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• Calcitonin : ↓ Ca level
• Vit D : ↑ Ca absorption in intestine
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Decreasing factors Osteoporosis
• Inactivity
• Long term Corticosteroid
• Malnutrition
• Menopause
• Decrease calcium absorption in intestine
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