Fisiologi SEL
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Transcript of Fisiologi SEL
1. MEMBRANE LIPIDS
Phospholipids (75%)DynamicBilayerAmphipathic
* Polar part: phosphate-containg “head”, hydrophilic
* Nonpolar part: two fatty acid “tail”, hydrophobic
MEMBRANE COMPOSITION
Glycolipids (5%)Faces external fluidFor adhesionBacterial toxin targetCell-to cell recognition and communicationContribute cellular growth and development
Cholesterol (20%)Strengthen the membrane, decrease flexibility
2. MEMBRANE PROTEIN FUNCTION
Channel
Transporter
Receptor
Enzyme
Cytoskeleton Anchor
Cell Identify Marker
MEMBRANE PHYSIOLOGY
1. Communication Interaction
• Other cell• Foreign cell, ligands
2. Electrochemical gradient Membrane potential
3. Selective permeability Lipid solubility Size Charge Presence of channel and
transporter
TRANSPORT ACROSS MEMBRANE
1. Simple Diffusion Concentration gradient Net diffusion Equilibrium
2. Osmosis Osmotic pressure Tonicity
- Isotonic- Hypertonic- Hypotonic
3. Bulk Flow Same direction Filtration
4. Facilitated Diffusion Transporter
- Channel
PASSIVE TRANSPORT
ACTIVE TRANSPOR
1. Primary active transport
Use ATP as the energy source- Ca2+ pump
- Na+, K+ pump
2. Secondary active transport
Use the ionic concentration difference (gradient)
Symport (co-transport)- Glucose transport
- Amino acid transport
Antiport (counter transport)- Na – Ca exchange- Na – H exchange
VESICULAR TRANSPORT
1. Phagocytosis Pseudopod phagocytic vesicle (phagosome)
2. Pinocytosis Pinocytic vesicle
3. Receptor-Mediated Endocytosis Similar to pinocytosis Import needed materials
4. Exocytosis
Receptor – mediated endocytosis
1. Ligand binds to receptor
2. Forming endocytic vesicle
3. Merging endocytic vesicle endosome
4. Within the endosome receptor separate from their ligands
5. Endosome containing receptor pinches off and moves back to plasma membrane
6. Endosome containing material merges with lysosome
MEMBRANE POTENTIAL
1. ION CHANNEL
Leakage (non gated) channel- K+ leakage channel > Na+ leakage channel
Gated channel- Voltage-gated (voltage-regulated) ion channel
- Chemically gated ion channel
- Mechanically gated ion channel
- Light-gated ion channel
2. RESTING MEMBRANE POTENTIAL
Polarized membrane
Unequal distribution of ion across membrane
Relative permeability of the membrane to Na+ and K+
• Potassium equilibrium potential (– 90 mV)
2. GRADED POTENTIAL The presence of chemically, mechanically, or light-gated
channel Small deviation from the resting potential that cause by an
appropriate stimulus Have different name, depend on type of stimulation Chemically gated ion channel postsynaptic potential;
sensory receptor receptor potential & generator potential Hyper-polarization & depolarization Most often in dendrite and body cell, less often in axon The electrical sign are graded, depending on the strength of
stimulus Localized current
Comparison of graded potential and action potential
Graded Potential Action Potential
Amplitude A variable size (1-50 mV) Same size (100 mV)
Duration Milliseconds – minutes ½ msec. – 2 msec.
Channel Chemical, mechanical & light gated channel
Voltage gated channels
Location Dendrite & Cell body Axon
Propagation Localized Propagate
Refractory period No refractory period Shows