Fetal Loss in AP Syndrome Placental Spiral Arteries Narrowing Intimal thickening Acute...

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Transcript of Fetal Loss in AP Syndrome Placental Spiral Arteries Narrowing Intimal thickening Acute...

Page 1: Fetal Loss in AP Syndrome Placental Spiral Arteries Narrowing Intimal thickening Acute Atherosclerosis Fibrinoid Necrosis Normal: Dilated Lumen Fenestrated.
Page 2: Fetal Loss in AP Syndrome Placental Spiral Arteries Narrowing Intimal thickening Acute Atherosclerosis Fibrinoid Necrosis Normal: Dilated Lumen Fenestrated.

Fetal Loss in

AP Syndrome

Placental Spiral ArteriesNarrowing

Intimal thickeningAcute Atherosclerosis

Fibrinoid Necrosis

Normal:Dilated Lumen

Fenestrated EndotheliumAbsent muscularis

Page 3: Fetal Loss in AP Syndrome Placental Spiral Arteries Narrowing Intimal thickening Acute Atherosclerosis Fibrinoid Necrosis Normal: Dilated Lumen Fenestrated.

Definition: ‘Complete 360 degree spiral course of umbilical vessels around Wharton jelly’

UCI = Total coils / length of cordStudied by USGNo coiling: 5-6% - Hypocoil: UCI <10th Centile – Hypercoil: UCI: >90th Centile

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UCI: indicator of AN / PN Outcome

Hypocoil predicts PIH – IUGR – Fetal Distress (FH Deceleration) – Low apgar – Meconium stain – Chorioamnionitis – Fetal Death

Pointed out by Edmonds 1954 & Lacro 1987Revisited by Strong et al 1994

Page 5: Fetal Loss in AP Syndrome Placental Spiral Arteries Narrowing Intimal thickening Acute Atherosclerosis Fibrinoid Necrosis Normal: Dilated Lumen Fenestrated.

Meta analysis: IUD – Meconium stain – PIH – IUGR - Operative intervention -De Laat et al 2005 Performed alongside Doppler in 2nd Trimester: ‘Best single factor to predict SFD babies’

Sensitivity 79% - Specificity 86% - Pos Pred Value 72% - Neg Pred value 90% - J ultrasound 2001

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Revision of Distance betweenBlades

Improvement in Locking System

Soft Blades with Rubber coating

Fabrication with Lighter Polymers

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• Forceps Blades coated with soft Rubber• RCT: 96 Deliveries ( 51 Soft forceps / 45

Traditional forceps )• Severe Facial Abrasions: 1.9% vs 4.1%• Minimal Marking: 34% vs 61%• Conclusion: better but needs improvement

- Roshan DF et al Int J ObG March 2005

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Computer enhanced Isometric Strength

Testing Unit

Leslie KL et al: Original ResearchObG 2005

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FINDINGS:*Useful tool for Forceps Training*On simulation most candidates used force above preferred range of>45 lbs without Visual Feed back*Improved on Acquisition Trial*Force exerted while Sitting wasMore than while Standing *Males used more Force than females

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John Hopkins Team

Least Forceful way to deliver Baby withShoulder Dystocia

3D Bony Pelvis – Flexible legs – Fetal Mannequin – Mock Uterus withPneumatic Pump – Force sensing Glovesto measure Traction Force – ComputerBased data acquisition system

- Allen et al Am J ObG Jan 2005

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Comparison of Rubin’s, Wood screw & Mc Robert’s

Least Force:R: 6.5 WS: 8.5 McR: 16 lbsStretch of Brachial plexus:R:2.9 WS: 6.9 McR: 7.3 cmExtra space under S Pubis:R & WS: 2cm McR: 1 cm

Rubin’s Technique whereAnterior shoulder is rotated& Fetal spine comesAnterior is the Best!

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Incidence in USA:16% (Adult 30%)3-fold Increase in 20 yearsWeight Gain recommended during Pregnancy: 11.5 – 16 Kg IOM-US10 – 12.5 Kg WHOExcess Weight Gain associated with Obesity in child at 3 yearsStudy of 770 mothers byGilman of Harvard Medical School & 1,90,000 families by Sharma of CDC, Atlanta

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CLOSURE OF PERITONEUMAt Caesarean Section

Cohort study of 173 casesClosure Vs Non closure:Adhesions: 52% vs 73%

Dense Adhesions: 30% vs 45%Conclusion:

Closure protects 5-fold against allAdhesions & 3-fold against dense

AdhesionsPractice of Non closure must be

Questioned?Lyell et al Original Research-

J ObG 2005

RCT: Absorbable Staples for closure of Uterine incision at LSCSStaples made of Copolymer (Polylactic+Polyglycolic acid)

Reduces Op time/Trauma/Blood loss/PO MorbidityAcceptable alternative

Hoskins et al Surg Ob Gyn 1991

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US National Academy of SciencesDeveloped Guidelines for ResearchOn Embryonic Stem cells in April ‘05In the section entitled ‘Inter Species Mixing”Authors concluded that there are valid reasons for creating Chimeras – Living entities composed of both Human & Animal cells!

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French surgeonsDubernard & Devauchelle

French Girl whose Face was mutilated by Dog bite

Finding Recipients easy!But finding dead donors difficult!

Involves challenging intricateSurgery & Immune suppressing drugs

Raises many Ethical issues

How would you like to live with Another person’s Face?

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Katie Holmes

Bought an Ultrasound MachineTo have a peek at his Baby!

Am U/S Society has raisedObjections & Questions the Wisdom of untrained personsPlaying with special equipment!

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