the

RecordU. S. DEPARTMENT OF

HEALTH, EDUCATION, AND WELFAREFebruary 15, 1972Vol. XXIV, No. 4 NATIONAL INSTITUTES OF HEALTH

. New Pharmacology LabTo Develop, Test Drugs For Treating Epilepsy

. •

Dr. Kupferberg is running the liquidchromatograph which separates themetabolites of anticonvulsant drugs.

The new lab's research is vital toNINDS's epilepsy drug evaluation pro-

grams.

•

.

A Pharmacology Laboratory, di-rected by Dr. Harvey J. Kupfer-berg, has been established in theNational Institute of NeurologicalDiseases and Stroke to speed thedevelopment and testing of newdrugs for treating epilepsy.

It is part of the Applied Neuro-logic Research Branch, headed byDr. J. Kiffin Penry.

Scientists in the new labora-tory will investigate how anti-epileptic drugs reach the brain,how they are absorbed, metabo-lized and excreted, and how theywork in combination or with

other drugs.Basic pharmacology—the search

, for new drugs—will be one of themain interests of the researchers.

' Studies VitalTheir studies on how to measure

the levels of new, experimentaldrugs in the bloodstreams of epi-lepsy patients will be vital toNINDS's epilepsy drug evalua-

* tion programs.These programs are of special in-

terest because about 40 percent ofthe country's 2 million epilepsypatients are not adequately con-trolled by existing antiseizuremedications.

According to Dr. Kupferberg,investigators will use gas-liquidchromatography in many of theirstudies. GLC is a standard method

(See NEW LAB, Page 5)

,

Dr. George Todaro Receives Gustav Stern AwardDr. George J. Todaro, chief of

the Viral Leukemia and Lym-phoma Branch of the NationalCancer Institute, received theGustav Stern Award during theeighth biennial Gustav Stern Sym-posium on Perspectives, in Virologyheld in New York, Feb. 7-8.

It is presented to a youngscientist for outstanding accom-plishments in virus research. Anhonorarium of $1,000 accompaniesthe award.

The award cited Dr. Todaro'scontributions to cancer and mo-lecular biology research; his de-velopment of the well-defined 3T3and 3T12 mouse embryo cell linesnow used extensively by cancervirus investigators, and his de-velopment of assay systems tostudy both RNA- and DNA-con-taining tumor viruses in animalcells and in human cells.

Currently, one of his major in-terests concerns the preparation ofantibody to certain cancer virusenzymes, in an attempt to identifyand characterize potential humancancer viruses.

Is Prolific Author

Dr. Todaro has authored or co-authored almost 50 publications in7 years.

He graduated from New YorkUniversity School of Medicine in1963. After internship there in

1964, he joined the staff as anassistant professor.

In 1967 Dr. Todaro came to NCI'sViral Carcinogenesis Branch, be-coming head of the Molecular Bi-ology Section in 1969, and chief ofVLLB in 1970.

Dr. Todaro was one of Ten OutstandingYoung Men of America named by theU.S. Jaycees in 1970 and the recipientof a DHEW Superior Service Awardlast year.

Increased Funds EarmarkedFor Projects to RenovateResearch Animal Resources

An additional $1.5 million hasbeen earmarked for increased em-phasis on projects to improve in-stitutional animal resources.

The stepped-up grant programof the Division of Research Re-sources' Animal Resources Branchis designed to improve the qualityof biomedical research usingwarm-blooded animals.Aids Policy Compliance

The program will also assistinstitutions in complying withthe Animal Welfare Act of 1970and NIH policies on the care andtreatment of animals.

There will be no specific dollarlimitation on the grants exceptin the renovation category, ac-cording to A n i m a l ResourcesBranch officials.

Although new construction isnot authorized under the pro-gram, renovation funds up to$75,000 may be awarded.

Funds may be obtained to pur-chase equipment such as cages,cage washers, and autoclaves.Support will also be made avail-able for travel, consultant serv-ices, and key professional andsupervisory personnel for the im-proved management of the animalresource.

AHA Names Thomas D. HatchTo Its Roll of Honor for 1971

Thomas D. Hatch, acting direc-tor of the Division of AlliedHealth Manpower, BHME, is oneof five Federal employees namedto the American Hospital Associa-tion 1971 Roll of Honor.

Mr. Hatch was cited for his out-standing contribution toward im-proving the health care systemthrough work on the Special Com-mittee on Career Mobility.

Leon Schwartz IsAssociate DirectorFor Administration

Mr. Schwartz, who holds NIH's topadministrative post, received the DHEWSuperior Service Award while with theOffice of Education.

Leon M. Schwartz has been ap-pointed Associate Director for Ad-ministration at NIH.

Mr. Schwartz comes here fromthe National Science Foundation,where he has been Deputy Assist-ant Director for Program Manage-ment for the past year.

He will act as principal adviserto the Director on administrationand on the management implica-tions of NIH's plans and pro-grams.

Duties OutlinedIn addition, he will be respon-

sible for overall management andadministrative policy, including fi-nancial and personnel manage-ment, planning of new NIH con-struction and operation of itspresent physical plant, central ad-ministrative services, and contract-ing and grants management activi-ties.

Mr. Schwartz, 43, was DeputyAssistant Commissioner for Ad-ministration, then Assistant Com-missioner, with the Office of Edu-cation from 1967 to 1971.

He spent some 7 years withNASA's Goddard Space Flight

(See MR. SCHWARTZ, Page 8)

Page 2 February 15, 1972 THE NIH RECORD

RecordPublished biweekly at Bethesda, Md., by the Publications and ReportsBranch, Office of Information, for the information of employees of theNational Institutes of Health, Department of Health, Education, andWelfare, and circulated by request to interested writers and to investi-gators in the field of biomedical and related research. The content isreprintable without permission. Pictures are available on request.The NIH Record reserves the right to make corrections, changes or dele-tions in submitted copy in conformity with the policies of the paper andthe Department of Health, Education, and Welfare.

NIH Record Office Bldg. 3 1 , Rm. 2B-03. Phone 49-62125

Editor Frances W. DavisAssistant Editor Fay LevieroStaff Writer Ed Driscoll

Staff Correspondents

ADA, Nelson Sparks; BHME/OD, Florence Foelak; CC, Ann Bain-bridge; DAHM, Laura Mae Kress; DBS, Faye Peterson; DCRT, JoanChase; DDH, Carolyn Niblett; DMI, Marian R. Fox; DN, Evelyn Laz-zari; DPHPE, Eleanor Wesolowski; DRG, Sue Meadows; DRR, JerryGordon; DRS, Robert Knickerbocker; FIC, Lois P. Meng; NCI, Eliza-beth Shollenberger; NEI, Julian Morris; NHLI, Bill Sanders; NIAID,Krin Larson; NIAMD, Katie Broberg; NICHD, Lloyd Blevins; NIDR,Sue Hannon; NIEHS, Elizabeth Y. James; NIGMS, Wanda Warddell;NIMH, Daniel Rice; NINDS, Anne Tisiker; NLM, Roger Gilkeson.

NIH Television, RadioProgram Schedule

RadioDISCUSSION: NIH

WGMS, AM—570—FM Stereo103.5 Friday, about 9:15 p.m.

February 18Dr. Robert S. Northrup, DBSSubject: Cholera (Part 2)

February 25To be announced.Interview during intermission,

Library of Congress concerts.

TelevisionPANORAMA

(Ask the Doctor)WTTG-TV, Channel 5, 12:30

p.m.February 17

Dr. Alfred S. Ketcham, NCISubject: Facts about Cancer

February 22Dr. Jerome B. Block, CCSubject: Modern Trends in Re-

search HospitalsFebruary 24

Dr. John P. Adams, G.W.U.(NIH Fellowship—NIGMS)

Subject: TraumaFebruary 29

Dr. Ralph E. Johnson, NCI

Vidct Jo Niebuhr, First Chief,Physical Therapy Service, Dies

Vida Jo Niebuhr, the first chiefof the Physical Therapy Service,CC Rehabilitation Department,died on Feb. 7 in West Allis, Wis.,of a cerebral hemorrhage.

Miss Niebuhr had served 30years with the Federal Govern-ment, including 17 years at theClinical Center.

Upon her retirement last Au-gust (see the NIH Record, Aug.17, 1971), she had returned to herhome town in Wisconsin.

Sailing Club Plans Busy ProgramFor Coming Season—Apply Now

The NIH Sailing Association,sponsored by the Recreation andWelfare Association, is planning anumber of spring activities.

Qualified members may charter—at low rates—one of the threeFlying Scot sailing vessels main-tained by the association.

The club's activities include in-formal racing, cruising, and atraining program in the rudimentsof sailing.

For further information call:Stu Wright, Ext. 67851; SteveLeighton, Ext. 64426; Jack Leach,Ext. 65270, or Rick Newell, Ext.64957.

FederaSubjectl Professiona: Radiation anl Associatiod Cancer n Holds Annual Meeting Feb. 23The NIH-NIMH Chapter of the higher and commissioned officers

Federal Professional Association are eligible to join.will hold its annual meeting on Members and eligible employeesWednesday, Feb. 23, at 3 p.m. inConference Room 10, Bldg. 31. are invited to attend. For further

Civil servants in the classifica- information, call Dr. Harold M.tion series that goes to GS-13 or Davidson, Ext. 67055.

Housewife Has Triplets—Is Star StudentIn NICHD Program on Infertility Causes

A Montgomery County housewife with an infertility problem recentlygave birth to triplets—two boys and a girl—whose combined weighttotaled 15 pounds, one ounce.

The housewife, whose infants were born in George Washington Univer-sity Hospital, has been a partici-pant of a research program on thediagnosis and treatment of infer-tility at the Reproduction Re-search Branch, National Instituteof Child Health and Human De-velopment.

Because of this problem, af-fecting 15 percent of couples inthe U.S., she was referred to theprogram in 1970 by her obste-trician-gynecologist.

In an effort to determine themalfunctioning area that causesinfertility, researchers at theNICHD Branch study the repro-ductive cycle of each patient whoundergoes tests for hormonal ab-normalities and anatomic defects.

Examination Explained'Laparoscopy — an examination

of the pelvic organs with an en-doscope (an instrument for in-specting any cavity of the body)—may determine some anatomicdefects.

Biopsies, taken through an ab-dominal incision of less than one-half inch, also help to identifyproblems.

The housewife was in that partof the NICHD program having todo with female infertility result-ing from the stoppage of themenstrual function. The Instituteis also undertaking research onmale infertility.

Dr. Jay Grodin, who directedthe study program in which themother of triplets was enrolled,sees his patients at 8 every morn-ing. Most of the women areworking wives and come to theclinic en route to their jobs.

The women also have their ownpersonal counselor—Irene Morelli—nurse supervisor for the group.

Fertility drugs are administered

in cycles corresponding to ovula-tion; the young mother under-went many cycles of treatmentprior to the conception of trip-lets. Hers is the only multiplepregnancy that has so far oc-curred in this program.

Dr. Grodin and Miss Morelliguessed that a multiple pregnancyhad taken place, and arrangedfor sonography in a District hos-pital.

Sonography is a process usinga recording device (sonograph)which sends ultra sound wavesthrough the uterus on to a sono-gram (chart) detecting the num-ber of children.

This was taken at 6 weeks ofgestation, and indicated three or ipossibly four babies. Subsequentstudies distinctly showed three—X-rays at the Clinical Centerhere confirmed the diagnosis.

At delivery, Dr. Grodin waswith the patient's obstetrician toaid, in the birth of the triplets.The babies were born only threeweeks premature.

Weight Given

Mark Louis, the firstborn,weighed in at 5 lbs. 11 oz., DavidJay, the smallest, weighed 4 lbs.3 oz., and last to arrive, LisaAnnette, weighed 5 lbs. 3 oz.

Mark and Lisa were placed inthe hospital nursery with theother full term babies, and onlyDavid went to the Intensive CareNursery, where preparations hadbeen made to accommodate thethree infants.

The patient and her husbandare elated at the successful out-come of her pregnancy, and bothare extremely happy that all threebabies were born healthy.

.

Lisa, the youngest of the triplets, flanked by her two brothers, Mark (I) andDavid exercises her lungs while the boys peacefully nap. All three were to stayin the Intensive Care Nursery, but only David, the smallest, was sent there fora short time.

THE NIH RECORD February 15, 1972 Page 3

Teaching Machine, AutotutorAllows Students to StudyCourses at Their Own Pace

A number of courses using theAutotutor—a teaching machine—is being offered by the Office ofPersonnel Management. This ma-chine allows a "student" to studya course by himself and at hisown pace.

The Autotutor employs a meth-od described by educators as "pro-grammed instruction." This typeof teaching separates a lessoninto components, and asks thestudent questions on that mate-rial.

If he knows the answers hemoves ahead to more complexmaterial—if he is wrong he goesback and starts over again.

Resembles TV SetThe Autotutor looks like a

television set with a series ofbuttons on the front of the ma-chine that may be punched for

multiple choice answers. Eachcourse is on a films-trip that isloaded into the machine.

Autotutor courses that are of-fered through May include: In-troduction to Computer Mathe-matics; Computers—a Four PartCourse in 'Programming; Ele-mentary Electronics, and BasicStatistics.

Other courses that will bescheduled for a later date in-clude: Effective Executive Prac-tices; Introduction to PERT; Im-proving Your Punctuation, and

•

s

County and Maryland State Fairs this year alone

Despite all the time she spends peeling, paring, slicing and dicing

Fair, six of which were firstplace.

Each y e a r the MontgomeryCounty Fair awards an engravedsilver tray to the participant whoearns the most blue ribbons.

Three years ago Mrs. Fletcher(See THELMA FLETCHER, Page 7)

the ingredients for her canned

Pinpoints Problems

The employment problems ofwomen in three grade levelgroupings—GS 1 through 7 andtheir equivalents, 8 through 12,and 13 through 18—are pin-pointed.

Recommendations stress the in-creased participation of femaleemployees in upward mobilityprograms, the changing of atti-tudes towards women in manage-ment and supervisory positions,and increasing the number ofwomen in program managementpositions.

In addition, the report listsproposals on child care, maternityleave, and part-time employmentpolicies.

Report Clarified

That part of the report dealingwith equal employment oppor-tunity for all women with partic-ular relevance to NIH pro-grams include: the development oflegislation to prohibit discrimina-tion in employment by institu-tions receiving grant funds, andproposals to end sex typing in thehealth professions.

Copies of the full report areavailable from Adele Nusbaum,coordinator of the F e d e r a lWomen's Program, NIH, in Room2B-32, Bldg. 31.

Terming sex prejudice as "per-haps the most ironic of our na-tional injustices," Secretary Rich-ardson described women as "thelargest single majority group inour population against w h i c hAmerica has traditionally prac-ticed discrimination."

The report also outlined provi-sions for the continuing develop-ment and monitoring of theprogram at HEW. On the depart-ment level, the responsibility hasbeen placed in the offices of theAssistant Secretaries for Plan-ning and Evaluation and for Ad-ministration and Management.

At the agency level these func-tions are assigned to the FederalWomen's Program coordinators.

Terms Prejudice 'Ironic'

In a series of briefing sessionsfor the press, agency heads, EEOofficers, Federal Women's Pro-gram coordinators, and women'sorganizations, HEW Secretary El-liot L. Richardson presented thereport of the Women's ActionProgram.

He called it an "agenda for ac-tion, focusing on HEW programsand policies for women and look-ing beyond them to an overallchange in the treatment of womenin our society."

Richardson Calls ReportsOn Women's Programs

An Agenda for Action'

p i c k l e S j f r u i t e ; a n d p r e s e r v e S j b u t

o n l y c a n g b e e f a n d c h i c k e n f o rf a j r e n ( ; r j e s

A t b o t h ' t h e C o u n t y a n d s t a t e

Fairs Mrs. Fletcher's pear pre-serves and cantaloupe pickles wonfirst place; her peach butter alsowon top billing at the State Fair.

While canned fruits, vegetables,and meats are judged on the basisof color, texture, and appearancein the jar, pickles, preserves, andjellies are actually sampled by thejudges.

It is personal taste, Mrs. Fletch-er believes, that is most importantin the judges' decisions. Her ownfavorites are sWeet relish andbread and butter pickles.

But her German chocolate cakeand banana and Hawaiian breadshave won ribbons. She also pre-pares a personal specialty whichshe calls "glorified banana bread."This includes chocolate chips, ba-nanas, maraschino cherries, andnuts.

This year Mrs. Fletcher won 55ribbons at the County Fair, in-cluding 20 first-place entries. Shealso won 22 ribbons at the State

Mouth-Watering Description

Two brothers, David and Harold Boesch(seated), as CC normal volunteers, aretaking part in an NCI DermatologyBranch test in which Dr. A. E. Miller(standing) and Dr. William Levis use aspecial tool to obtain skin biopsies. Thetool, a keratome, cuts so close to thesurface—superficially—no scars result.The test will help develop a system forstudying homograft rejection (rejectionof donated organ or tissue) in vitro.

goods, Mrs. Fletcher still man-ages to work full-time.

She is a laboratory technicianin the Medical Neurology Branch,National Institute of NeurologicalDiseases and Stroke.

Early Morning Baker

In her spare time she enjoyscanning various vegetables, fruits,and meats, as well as bakingbreads and cakes. Sometimes her"spare time" is at 2 or 3 in themorning.

Mrs. Fletcher doesn't mind thehours, though. "It's what keepsme going," she explains. "I'mfrom a large family where we al-ways canned and baked. I enjoy itand like to try new recipes."

As for the green thumb, it be-longs to Mrs. Fletcher's husband,Reynold, who is also a laboratorytechnician at NIH.

In the yard of their Gaithers-burg home, he grows many of thevegetables she uses in her prize-winning recipes.

"My husband enjoys gardening,"Mrs. Fletcher explains, "and be-sides, he says there's no sense incutting the grass when we cangrow something out there to eat."

Mr. Fletcher has also won rib-bons for the quality of his vegeta-bles, particularly his peppers andonions.

Each year Mrs. Fletcher canshundreds of pints of vegetables,

Mrs. Fletcher, whose co-workers in theNINDS Medical Neurology Branch enjoythe fruits of her labors, displays herprize-winning canned goods and theribbons they have earned.

What happens when a green thumb is combined with culinary ex-pertise? For Thelma R. Fletcher the answer is a blue ribbon—several,in fact.

Mrs. Fletcher won 26 first-place blue ribbons for her canned andbaked goods at the Montgomery .

Thelma Fletchers Breads, Jellies, PickleWin Ribbons at Fairs, Plaudits of Friend

By Bonnie Friedman

About 19 percent of Ph.D.'s inthe U.S. are foreign-born. Almost15 percent are foreign citizens,and from 1965 to 1968, 43 percentof these planned to remain in thiscountry.—Mobility of Ph.D.'s.

Statistics on Foreign-Born Ph.D.'s

Improving Your Writing.For further information call

B/I/D personnel offices, or BettyKitterman, Training and Employ-ee Development, Ext. 62146.

A student ponders over what buttonto punch in answer to a question bythe Autotutor. Each course is on afilmstrip loaded into the machine.

Page 4 February 15, 1972 THE NIH RECORD

The establishment of a new of-fice—the Office of Clinical andManagement Systems—has beenannounced by Dr. Thomas C.Chalmers, Clinical Center Direc-tor. It will be responsible forstudying and modifying CC in-formation systems, including theincreased use of computerized in-

formation.Among the projects that are

being considered is an informa-tion system which would enableresearchers to obtain a list ofpatients with their diagnosis, themedications that they have re-ceived, and the results of theirlaboratory tests.

The newly established officewill also help plan and carry outa hospital management analysisprogram.

Dr. Rourke Is Chief

Dr. Anthony J. J. Rourke, Jr.,has been named chief of this of-fice. Before joining CC in 1970,Dr. Rourke was a postdoctoralfellow in the Computer Programand Information Science Depart-ment, University of Missouri Med-ical Center.

He specialized in computer in-formation systems that aregeared to medical hospital envi-ronments; he also served as aconsultant in hospital design.

Dr. Thomas L. Lewis and Ger-ald C. Macks have been namedassistants to Dr. Rourke.

Dr. Lewis, a clinical associate,served his internship at YaleMedical School. He was a com-puter systems analyst at the Har-vard University Computer Centerfor 4 years, and a consultant inhealth care delivery systems forthe Census Bureau.

Mr. Macks, a management an-

Children Chew Gum Containing PhosphateIn NIDR Study; May Reduce Tooth Decay

A school is actually giving its pupils chewing gum. The gum, whichcontains a phosphate, is being tested as a tooth decay preventive.

The University of Alabama in Birmingham (UAB) is doing the studywith support from the National Caries Program of the National Instituteof Dental Research.

Today 98 percent of Americanshave tooth decay; the average childhas three decayed teeth by the timehe enters school and 11 by age 15.

Dr. Sidney B. Finn, UABSchool of Dentistry's Institute ofDental Research, is testing theeffectiveness of sodium trime-taphosphate in children becausestudies with laboratory animalshave shown that it can reducetooth decay.

Simple Way to Prevent Decay

If it works as well in children,then dentistry would have a pleas-ant and simple-to-use way to helpprevent decay.

Participating in the researchare 600 children who live at theFlorida School for the Deaf andBlind during the academic year.Both the children and their fami-lies are enthusiastic because theyoungsters receive dental careand may benefit from a new pre-ventive.

The participants enjoy freegum every school day as well ason vacations when enough gum isprovided for the entire family.

Four groups of children arebeing compared. The first groupchews a sugarless gum with thephosphate, the second, a gum con-taining both the phosphate andsugar, the third, a plain sugar-less gum, and the fourth groupreceives no gum.

Every day each child will chewthe same type of gum for at least10 minutes after breakfast, afterlunch, and shortly before bed-time.

All the children eat the samefoods, an important factor be-cause diet affects dental health.

The children's teeth are checkedfor decay at the start of thestudy and again every 6 months.Group comparisons will indicatewhether the phosphate protectsthe teeth against decay.

alyst, has had considerable expe-rience in studies of hospital sys-tems stressing computer applica-tions.

He holds a B.S. in IndustrialEngineering and an M.S. in Per-sonnel Administration.

Jane Wynn Hay Will DirectRegional Nursing Programs

Jane Wynn Hay, Division ofNursing, BHME, has been chosenregional nurse program directorfor the HEW Regional Office inBoston, Mass.

Mrs. Hay will consult withagencies and institutions in theNew England states on improvingconditions in nursing educationand practice.Coordinates 6-State Area

She will coordinate DN pro-grams with related programs inthe six-state regional area, andhelp determine health and welfarepriorities.

Mrs. Hay, with the Federalnursing services since 1961, hasbeen with DN for the past 4years as the assistant regionalnurse program director in theHEW New York office.

Earlier, she was with the HeartDisease Control Program and theDivision of Medical Care Admin-istration.

• : • >

Clinical Center patients observedValentine's Day with parties for adultsand children, a bingo game with aValentine theme, and a crafts work-shop where children made lace andflower valentines for their mothers.

The Royal Harmonizers, spiritual singers, receive awards from the CanaanBaptist Church for outstanding contributions to community betterment—theyhave given many church benefit performances. I to r are: Victor Chance, CC,Fuller Ming, NIGMS, and James Ridgley, NCI. Two other Harmonizers not pic-tured are Berkley Bell, M.C. School Board employee, and William Ridgley, EPA.

Growing Interest in Use ,Of Audiovisuals Noted 1

By N. Tucker in SpeechEquating the present state of

the use of audiovisuals in medical Jeducation with the Tower ofBabel, Norman Tucker delivered •the keynote address at the Na-tional Audio-Visual Association's 'Midwinter Conference in KeyBiscayne, Fla., last month. 1

Mr. Tucker is with the Divi-sion of 'Physicians and HealthProfessions Education, BHME.

He stressed the need for man- •ufacturers of audiovisual equip-ment and programs to gear prod- iucts to the needs of consumers.

Problems Described"Incompatability of soft and -

hardware, confusion, lack of focifor clearinghouses, and stand- -ardization are but a few of thetraits that have compounded this <Tower of Babel," he said.

Interest in the development ofmultimedia approaches to healthmanpower education has been slowin getting started, he noted, butsuddenly, in 1971, at the Media70's Conference in Cincinnati,there was an explosion of interest. •Instead of the customary 300-400participants, 1,000 attended.

Mr. Tucker observed a grow-ing Federal concern directed tothe use of audiovisuals.

In July 1971 the Office ofAudiovisual Educational Develop-ment was established in BHMEto serve as a national focal pointto investigate and promote theuses of these new technologies formedical education.

This Office coordinates Bureauprograms in the multi-media teach-ing field with the National Libraryof Medicine's National MedicalAudiovisual Center.

Dr. Rourke (standing) analyzes a com-puter printout with Dr. Lewis (I) andMr. Macks. Their office will help plana management analysis program forhospitals.

Computer InformationUndergoes Study in CC'sNewly Established Office

THE NIH RECORD February 15, 1972 Page 5

The National Heart and LungInstitute will undertake a large-scale clinical trial to determine towhat extent illness and deathfrom coronary heart disease canbe reduced by modifying or elimi-nating three common risk factors.

NHLI's Clinical ApplicationsProgram is inviting contract pro-posals to develop and conduct aMultiple Risk Factor ControlledClinical Trial.

Purpose Defined

Its purpose is to determinewhether a preventive programaimed at reducing elevated serumlipids, blood presure, and ciga-rette smoking among high-riskmales aged 40-59 can achieve asignificant reduction in heart at-tacks and death from coronaryheart disease over a 6-year periodof medical supervision.

Approximately 80 percent ofdeath and disability from car-diovascular diseases occurs amongpersons having one or more ofthese risk factors working againstthem.

Framingham Data Noted

Two or more risk factors arecommonly present in the sameindividual, and those with allthree risk factors are an especiallyhigh risk from arteriosclerosis andacute heart attacks.

For example, data gatheredfrom the NHLI-sponsored Fram-ingham Heart Disease Study showthat men with one risk factor hada clinical incidence of coronaryheart disease of 1.9 times the rateof men with none of these riskfactors.

With two risk factors, the inci-dence was 3.4 times higher, andwith all three factors, the inci-dence was 10.6 times that foundamong men with none.

Select Best Contractors

Contracts for the Clinical Trialwill be awarded to medical in-vestigators judged best qualifiedto handle and maintain the pro-gram from its start through the6-year follow-up period.

Each center must have adequateclinical facilities for at least 600men with high risk factors andmanage at least 300 high risk par-ticipants in the study group.

They will be seen at least 4 to 6times per year. Members of thecontrol group will be seen once ayear.

Men recruited by each centerwill receive medical and labora-tory evaluation at the start of theprogram and periodically over 6years of follow-up.

A special program relating to

NEW LAB(Continued from Page 1)

of measuring small quantities ofsubstances in solution that hasbsen recently adapted to deter-mine drug blood levels.

Blood levels are important be-cause it is the amount of a drugin a patient's body, not theamount taken, which helps toprevent seizures. And it is knownthat individuals differ in their ab-sorption, excretion, and metabolicrates.

Investigators Use GLC

For each new drug proposed forclinical trials, investigators willuse GLC to establish reliable dataabout the effectiveness and side ef-fects, and to set blood level guide-lines.

Three new experimental drugsfor epilepsy are now being testedin clinics at several research cen-ters. The clinics are under con-tract with the Applied NeurologicResearch Branch.

Dr. Kupferberg Develops Tests

The GLC test and evaluationmethods used in these trials weredeveloped by Dr. Kupferberg be-fore he came to NIH last fall.Then, he was an assistant profes-sor in the Department of Phar-macology at the University ofMinnesota.

From 1963-65, Dr. Kupferbergserved as a staff fellow in theLaboratory of Chemical Pharma-cology, National Heart and Lung-Institute.

Isolation of Brain Cell 'Glue FacilitatesTissues Synthesis From Test Tube Cells

Albert T. Lenz, a plasterer in the Car-penter Shop, Plant Engineering Branch,ODA, retired after 30 years Governmentservice—19 with NIH. Friends and co-workers held a farewell party for himlast month.

diet, blood pressure reduction, andreduction or discontinuation ofcigarette smoking will be under-taken for one half of the par-ticipants.

The remainder will be referredback to their personal physiciansor usual medical care centers.

EMBRYONIC TISSUE was constructed in vitro—individual cerebrum cells (I) from14-day mouse embryos aggregate only slightly after 24 hours. The cerebrumcell-ligand, a "glue"-type material which has been isolated accelerates theaggregation. The cells group closely together after 24 hours (r). The bar inFigure b represents 0.5 millimeter.

University of Chicago scientiststissue in vitro from suspensions ofsupported by the National Institutevelopment.

They performed this feat withcells isolated from the cerebrumof mouse embryos and with aspecific cellular "glue"-type ma-terial which they obtained fromcerebrum cells.

This material, referred to ascerebrum cell-ligand, links togetheronly cerebrum cells. Other kinds ofbrain cells appear to produce theirown specific ligands.

Two biologists, Drs. Ayon A.Moscona and Beatrice B. Garber,explain that the cerebrum cell-ligand material coats the surfacesof the cerebrum cells which pro-duce it.

"Because of its molecular prop-erties this material makes thesecells stick together to form braintissue," said Dr. Moscona.

Cells Identify Each Other

"Moreover, it enables cells to'identify' each other by 'coding' thecell surface with molecular identi-fication markers.

"This makes cerebrum cells 'rec-ognize' each other as being distinctfrom other nerve and from non-nerve cells andi causes them to as-sociate with each other to formcerebrum tissue.

"If they are mixed with cellsfrom other tissue, cerebrum cellsdistinguish like from unlike andadhere only to each other."

This is the first instance of iso-lation of such a specific cell-binding material from mammaliancells. The possibility of obtainingthem from brain cells and of"synthesizing" tissues from cellsin the test tube opens up newways of studying tissue forma-tion and brain development.

Dr. Moscona presented thesefindings last autumn at an inter-national symposium in London and

have constructed embryonic brainsingle brain cells during researchof Child Health and Human De-

the complete reports of his and Dr.Garber's work appeared in theFebruary 1972 issue of Develop-mental Biology.

All tissue-cells in the embryoare believed to carry on their sur-faces such ligands for mutualrecognition and selective adhesionof cells into tissues. In fact, simi-lar ligand materials were pre-viously obtained by Dr. Mosconaand his associates from otherkinds of cells.

Aims Explained

"The aim of this work was toexplain one of the most importantand hitherto elusive problems inbiology—how cells associate intotissues? How different kinds ofcells in the embryo recognize eachother and assemble into complexsystems? " commented Dr. Mos-cona.

"The discovery of specific cell-ligands represents a major steptowards solution of these problems.It now becomes possible to studythe biochemical nature and detailedmode of function of these specificcell-ligands.

Has Important Implications

"Such information will contri-bute not only to fundamental bio-medical knowledge, but may haveeventually important medical im-plications, especially with respectto birth defects and cancer," hesaid.

Dr. Moscona is professor in theDepartment of Biology and on theCommittee on Genetics in the Di-vision of the Biological Sciencesand The Pritzker School of Medi-cine at the University of Chicago.Dr. Garber is assistant professorin the Departments of Biology andAnatomy.

Program to Evaluate 3Common Risk FactorsIn Heart Disease Begins

Page 6 February 15, 1972 THE NIH RECORD

The principal investigator for

Dr. Deanne E. Knapp, social psychol-ogist in the Office of Social and Be-havioral Analysis, Division of DentalHealth, BHME, is included in the fourthvolume of "Two Thousand Women ofAchievement," to be published in No-vember 1972.

Society Invites PathologistsTo Join New Organization

A Society of Pharmacologicaland Environmental Pathologists,recently formed in New Jersey, iscomprised of members from thepharmaceutical industry, the gov-ernment, universities, and privatepractice.

The president of the society isDr. Hans Keysser, Director of thePathology Department, SquibbInstitute for Medical Research.

Objectives include fostering thediscipline of pharmacological andenvironmental pathology and es-tablishing a registry of naturallyoccurring and induced diseases inlaboratory animals.

Interested pathologists shouldcontact Dr. Howard M. Hartman,secretary-treasurer, P.O. Box 276,Florham Park, N.J. 07932.

Four visitors watch the computer givedonor information at the ClinicalCenter Blood Bank. Some 400 NIH em-ployees attending an Open House Jan.31 learned about the work of theBlood Bank and its urgent need formore donors. Levi Carter, DRS, won the17-inch color portable donated by theNIH R&W Association. A 4-year-old CCpatient drew his name from a pool ofover 3,000 names of employees whohad donated blood since last Aug. 1 .

Hebrew Medical School Attempts StudieOn Treating Cancer by Immunotherapy

The National Cancer Institute is funding cancer research studiesat an Israeli medical school in Jerusalem to treat the disease by im-munotherapy—bolstering the body's natural defense against cancer.

this research is Dr. David Weiss,chairman of the Department ofImmunology, Hebrew UniversityHadassah Medical School in Jeru-salem.

Dr. Weiss will try to discoverhow the body's natural immunityis most likely stimulated by atuberculosis vaccine extract calledBCG.MER to Be Tested

BCG is a living culture of tu-berculosis bacteria (Bacillus Cal-mette-Guerin) and the methanol-extracted residue to be tested iscalled MER.

In previous NCI studies of im-munotherapy in animals, wholeBCG has been used in a mixturewith live cancer cells, and regres-sion of the cancer growth hasresulted.

Problems associated with the useof live bacteria—for example, de-velopment of abscesses in lymphnodes, and complications in lungsand other organs—are less severewhen MER is used.

Resistance Increased

Dr. Weiss previously demon-strated in mice and other ani-mals that immunologic capacityand resistance to experimentallyinduced tumors are increased afterinoculation with MER, and theincidence of spontaneous tumorsis decreased.

Now he will investigate the pro-tective activity of MER againstleukemia in mice under conditionsresembling those affecting cancerpatients—for instance, after theleukemic mice have been treatedwith irradiation or drugs.

Objectives NotedThe effect of MER will also be

tested in mice with impaired im-munologic responsiveness due toaging, irradiation, and cancer-pro-ducing chemicals.

The aim of this study is to findout the circumstances under whichMER is more likely to stimulateimmunoglobulin formation, and thecellular responsiveness of animalsto their own tumors.

Dr. Brigid G. Leventhal, seniorinvestigator in NCI's MedicineBranch, is the project officer forthis research.

She explained that to date, miceused to test MER have not beenpreviously subject to irradiation,surgery, or chemotherapy as arecancer patients to whom MER mayeventually be administered.

In the studies, pre-treated micewill be used in order to achieve

Solution Sought to SatisfyTeenage Desire for SnacksWithout Rise in Tooth Decay

Scientists are seeking ways forteenagers to satisfy their desirefor snacks without suffering anaccompanying rise in tooth decay—through a study supported by theNational Institute of Dental Re-search.

Under a contract from the Na-tional Caries Program—in an ef-fort by NIDR to make tooth de-cay preventable—a team headedby Basil G. Bibby of the EastmanDental Center, Rochester, N.Y.,will determine which commonsnack foods contribute most todecay.Snack Foods Studied

Laboratory, animal, and humanstudies will be conducted to findout whether sugar-free snacks,such as potato chips, are more orless conducive to decay than sweetsnacks, such as chocolate cookies.

Once snack foods have beencategorized for their decay—caus-ing potential, investigators willdetermine whether teenagers canbe persuaded to substitute lessdamaging foods, and whether thechange reduces decay.

The scientists will test hard andchewy candies, gum, cookies, cakes,breads, doughnuts, crackers, pea-nuts, and some fruits and bever-ages. »

In the laboratory, they will de-termine which foods soften or de-mineralize enamel slabs.

To relate laboratory findingswith what happens in the mouth,tooth-sized enamel slabs—worn byvolunteers like an artificial toothon a partial denture—will becompared With enamel exposed inthe laboratory.

pretesting conditions more closelyresembling the human situation.

One of these studies will be car-ried out jointly by Drs. Weiss,liana Eron, and Eliezer Robinson,chairman of the Department ofOncology of Rambam Hospital,Haifa.

"In recent years," Dr. Weiss ex-plained, "it has become increas-ingly evident that the capacity ofchemical and physical agents tosuppress immunity is related totheir cancer-producing capabilities.

"It may be that immunosuppres-sion is an essential characteristicof cancer-producing stimuli such asirradiation or aging.

"It would follow that raising theimmunity level to overcome the

s NLM's Exhibit FeaturesCollection of PhotographsBy Dr. William Feldman

A collection of portrait photo-graphs of distinguished American ipathologists—taken by an eminentscientist whose boyhood hobby ledhim to improvise equipment andtake his own photomicrographs—•are being featured in the NationalLibrary of Medicine's educationalexhibit through May 26.

Widely known for basic studies .in chemotherapy, Dr. William HughFeldman, former staff member ofthe Mayo Clinic, found his favoritephotographic subjects among hisprofessional friends and colleagues.

Many of the pictures in the col- •lection, which he recently gave to

Dr. Feldman, now 80, was chief of lab-oratory research in pulmonary diseasesat the Veterans Administration, Wash-ington, D.C. from 1957 to 1967.

the Library, were taken duringscientific meetings, in the labora-tory, or in his home.

With a twin lens reflex camera,Dr. Feldman would converse withhis subjects waiting for certainfacial expressions, which resultedin warm and personable like-nesses of the pathologists.

The exhibit, Pathology: TheStudy of Disease, in conjunctionwith the "Year of Pathology 1971-1972," is designed to acquaint themedical profession and the publicwith the expanding role of pathol-ogy in modern health care.

In addition to the Feldman col-lection, the exhibit will presentportraits of antiquarians in pa-thology, including Bonet, Mor-gagni, Virchow, and Bichat. Alsopresented are classical textbooksand manuscripts, and first editionsof modern works in pathology.

Other displays include patho-logic specimens prepared by NobelLaureate Dr. Peyton Rous and Dr.Max Lurie.

suppression of immunity automat-ically caused by a cancer-produc-ing agent may prevent an incipienttumor from developing progres-sively as a malignant growth."

THE NIH RECORD February 15, 1972 Page 7

Inventory of Programs ThatSupport Health ManpowerTraining Published by DMi

An Inventory of Federal Pro-grams That Support Health Man-power Training, 1970, has beenissued by the Division of ManpowerIntelligence, BHME.

The 92-page publication lists 144Federal programs which support-ed health manpower training in1970 under 13 Federal depart-ments and independent agencies.Support Listed

Of the 144 programs, 94 wereexclusively for health manpowertraining. Ninety-seven, or morethan two-thirds of the total num-ber of programs, were the respon-sibility of HEW, 42 of them ad-ministered by agencies withinNIH.

The inventory may be purchasedfor $1 per copy from the Superin-tendent of Documents, U.S. Gov-ernment Printing Office, Wash-ington, D.C. 20402.

Educators and others concernedwith health-related training, mayobtain a single free copy from theDivision of Manpower Intelligence,BHME, Bethesda, Md. 20014.

Requests should list the titleand number: DHEW PublicationNumber (NIH) 72-146.

Three New Members NamedTo NINDS Advisory Council

Three new members have beennamed to the National AdvisoryNeurological Diseases and StrokeCouncil.

They are Dr. Lyle Albert French,Vice President for Health ScienceAffairs and professor of Neuro-surgery, University of MinnesotaMedical School; Dr. Delyte W.Morris, President, Southern Illi-nois University, and Marie Plum-mer Orsat Daniel, Weldon, N. C,an active volunteer worker.

Dr. French received his M.D.and Ph.D. degrees from Min-nesota and has served there as amember of the faculty since 1947.Achievements Noted

A past president of the Ameri-can Speech and Hearing Associa-tion, Dr. Morris has been in-volved in speech development anddisorders for almost 40 years.

He was graduated from theUniversity of Maine with an M.A.and from the University of Iowawith a Ph.D. He serves as a con-sultant to the Veterans Adminis-tration.

Mrs. Daniel, a member of var-ious civic and church organiza-tions, received a B.S. degree fromSt. Augustine College. She at-tended Howard University forgraduate studies and also re-ceived special training in elemen-tary education at Savannah StateCollege.

Temporary Home AssistsPatients, Families AdjustTo Long-Term Disability

A modular home—a specially-designed prefabricated unit to beinstalled at the Stanford Univer-sity Medical Center—will serveas a "temporary home" for hos-pital patients and their familiesprior to returning to their ownabode.

The unit is part of a physicaltherapy training project support-ed by a grant from the Divisionof Allied Health Manpower,BHME.

Entitled "Family Focus," theproject will enable physical ther-apy students to work closely withpatients and families who mustmake the difficult adjustments tolong-term disability.

The only project of its kind in

Helen Blood (seated) acting director,Stanford's Division of Physical Therapy,looks over blueprint plans for the pre-fab modular home with Kay Shepard,physical therapy instructor and projectcoordinator. The dwelling will be usedduring the "adjustment period."

the country, Family Focus wasjointly planned and will be jointlyimplemented by Stanford's Divi-sion of Physical Therapy and theMental Research Institute, a pri-vate, non-profit institute based inPalo Alto.

Apart from the academic bene-fits, the project is expected tohave a significant impact uponthe patients and families involved,said Dr. John E. Bell, Director ofMRI and clinical associate pro-fessor of Psychiatry at Stanford.

Dr. Bell, who teaches a coursecalled "The Family in the Hos-pital," will take part in the in-struction and supervision of stu-dents in the project, along withother MRI staff members.

He emphasized the importanceof the family in physical therapy."A patient who returns homewith a handicap really upsetsthings," he said.

"The family has to take oversome aspects of physical therapy

Stanford Institute BeginsResearch on CarcinogenicEffect of Chemicals

A study on the carcinogenic(cancer-causing) effect of envi-ronmental chemicals in combina-tion with other chemicals is beingcarried out by scientists at theStanford Research Institute, MenloPark, Calif.

The National Cancer Instituteawarded a contract for this re-search. It will be administeredby NCI's Carcinogenesis Area.

Dr. Richard R. Bates, chief ofNCI's Experimental PathologyBranch ds project officer for thestudy. Dr. David C. L. Jones,senior immunologist, of the SRILife Science Division, is theprincipal investigator.

The effect of single chemicalscausing cancer will be comparedwith their carcinogenic abilitywhen combined with other chemi-cals.

Researchers hope to identifychemicals that inhibit the cancercausing effect of other chemicalsas well as identify those chemi-cals that increase it.

THELMA FLETCHER(Continued from Page 3)

won the tray, but according to theFair rules, she must wait 2 moreyears before she can claim itagain.

That stipulation c e r t a i n l ydoesn't stop Mrs. Fletcher's ac-tivities, for her fan club extendsbeyond the judges at the fairs.

Friends, relatives, and co-work-ers are often given samples of herculinary masterpieces. And it's nota one-way street either. Whiletraveling, these people often col-lect various fruits and vegetablesfor Mrs. Fletcher's kitchen.

One avid admirer is a youngcousin who, when offered ice creamand cake at her home, would rathersample her canned relish or vege-tables.

Mrs. Fletcher plans to rewardhim with a variety of her cannedgoods for his birthday.

which the therapist performswhen the patient is at the hos-pital. In the past, we've beenacutely aware that some familiesdon't do a very good job.

"The physical therapist canreally get involved with the fam-ily and do something about this.The new program gives us thisopportunity.

"By using the modular home,we can provide the family witha preview of how life will bewhen the patient returns home,and help them all cope with it."

The modular home will be setup to allow the family to engagein independent living. Adjacent,but separate from the living quar-ters, will be a combined staff

office and observation room.With the family's permission,

students will observe rehabilita-tion training and family-patient-staff conferences concerned withfamily readjustments.

Dr. J. Reese Joins DDHFor 1 Year Assignment

Dr. Reese will observe dental programshere, both intramural and extramural.

Dr. Joyce A. Reese, a dentistwith experience in health careprograms for underprivileged andminority groups, has begun aone-year assignment with the Di-vision of Dental Health, BHME.

Dr. Reese, who is a dental of-ficer with the D. C. Departmentof Public Health, will spend ayear on the staff of the Divi-sion's Education DevelopmentBranch, working on projectswhich provide direct dental careto minority group patients.

Her employment in DDH ismade possible through an inter-governmental training agreementbetween NIH and the D.C. Gov-ernment.

She received her B.S. degreefrom Virginia Union Universityin 1957 and her D.D.S. degreefrom Howard University DentalSchool in 1963.

Robert H. Cross has been named per-sonnel officer for the National Libraryof Medicine. Mr. Cross came to NIH in1965 as a personnel management spe-cialist in NCI. He has served as per-sonnel officer for NICHD, NEI, and DRR.

Page 8 February 15, 1972 THE NIH RECORD

Three Fogarty Scholars-in-Residence talk things over prior to a reception givenin their honor at Stone House on Jan. 28. L to r: Prof. Frank Fenner, Australia,Prof. Ragnar A. Granit, Sweden, and Prof. Rollin D. Hotchkiss, U.S.

President's New Cancer Panel PromiseQuick Start on Fight Against Disease

s

After the three-man Cancer Panel met with President Nixon on Jan.31, Chairman Benno C. Schmidt introduced the two new panel members,Drs. Robert A. Good and R. Lee Clark, and also promised an immediate

start on their efforts to combatcancer.

At a press conference held atthe White House, Mr. Schmidt saidthat the President had charged thepanel to "give the American pub-lic the best cancer program thatAmerican science and Americanmedicine can provide today."

Mr. Nixon also emphasized, Mr.Schmidt revealed, that he wantedthe effort to be an internationaleffort—both in benefits developedand in drawing upon the profes-sional skills of scientists and, doc-tors in all other parts of the world.

Dr. Good, a noted immunologist,is a professor of Pediatrics at theUniversity of Minnesota.

Dr. Clark is a distinguishedsurgeon and president of the Uni-versity of Texas M. D. AndersonHospital and Tumor Institute.

In answer to a reporter's query,Mr. Schmidt noted two areas of"encouraging progress," acuts leu-kemia and breast cancer.

Dr. Clark assured another re-porter that they will take a verycareful look at all available meansof treatment. He noted that since1956 the National Cancer Chemo-therapy Program has tried around250,000 drugs with 40 effective intreatment of some types of cancer.

What makes Dr. Good optimisticabout the problem of cancer, hedisclosed, is the tremendous de-velopment of basic knowledge ofcells during the last 20 years. Hefeels that a vigorous approach willi e a d t o unde r s t and ing the causesa n d d e f e n s e a g a i n s t cancer.

Think of the years wasted tryingto get along with people! And allthe while we were supposed to re-

late to them.—Changing Times.

HEW Secretary Elliot L. Richardson (r)congratulates Dr. William E. Bunney,Jr., on his appointment as Director ofthe Division of Narcotic Addiction andDrug Abuse, NIMH. Dr. Bunney will alsocontinue as chief of the Section onPsychiatry, Laboratory of Clinical Sci-ence, in the NIMH Division of Clinicaland Behavioral Research at NIH.

NIH Visiting ScientistsProgram Participants1/1—Dr. Zvi Vogel, Israel, Lab-

oratory of Biochemical Genetics.Sponsor: Dr. Marshall Nirenberg,NHLI, Bldg. 10, Rm. 6D18.

1/26—Dr. Alan M. Jeffrey,United Kingdom, Laboratory ofChemistry. Sponsor: Dr. John W.Daly, NIAMD, Bldg. 4, Rm. 227.

1/31—Dr. Vidula Bangdiwala,India, Analytical and SyntheticChemistry Branch. Sponsor: Dr.Edward Oswald, NIEHS, ResearchTriangle Park, N. C.

1/31—Dr. Hiremagalur N. Jay-aram, India, Laboratory of Toxi-cology. Sponsor: Dr. David A.Cooney, NCI, Bldg. 37, Rm. 5B22.

Sessions on Natural FamilyPlanning Held in Warrenton

A conference on natural familyplanning, sponsored by the Nation-al Institute of Child Health andHuman Development and the Hu-man Life Foundation, was recent-ly held at Airlie House in War-renton, Va. It was attended by re-searchers from medical, scientific,and social science backgrounds.

At one of the sessions duringthe 3-day meeting, Dr. Alan E.Treloar discussed the lack of in-formation in the field of humanreproduction.

He suggested the establishmentof a central data bank for storinginstant retrieval i n f o r m a t i o nabout conception and its regula-tion to permit interpretation freeof personal viewpoint.

Dr. Treloar, head of NICHD'sReproduction Anthropometry Sec-tion, was lauded for his sugges-tion by the investigators attend-ing the meeting.

The conference was co-chairedby Dr. William A. Uricchio, chair-man, Department of Biology, Car-low College, and Dr. Philip A.Corfman, director of the Centerfor Population Research, NICHD.

Dr. Uricchio is also a memberof the Board of the Human LifeFoundation, a non-sectarian re-search organization interested instudies of natural methods of fer-tility control. Its work includesthe exchange of information witha number of countries.

DRS Changes Branch NameTo Veterinary Resources

The name of the Division ofResearch Services' LaboratoryAids Branch has been changed tothe Veterinary Resources Branch.

The new name clarifies thebranch's overall mission of pro-viding NIH investigators with liv-ing models and life support sys-tems for biomedical research.

These include research animals,tissue cultures, and microbiologicmedia.

In addition, the branch provides

MR. SCHWARTZ(Continued from Page 1)

Center in Greenbelt, Md., andserved as chief of Program Reviewand Resources Management priorto joining the Office of Education.

Mr. Schwartz was assistanttreasurer and chief accountant ofCarpel, Inc., from 1954 to 1960.

He served as an instructor inAccounting at Baltimore Institutefrom 1958 until 1963.

Mr. Schwartz, who is a CertifiedPublic Accountant, received hisB.A. degree in Economics fromJohns Hopkins University in 1950.

Honors accorded him include a4-year Alumni Scholarship atJohns Hopkins University and theDEHW Superior Service Award.

Dr. Edward Driscoll Wins1972 Heidbrink Award

Dr. Edward J. Driscoll, chief ofthe Anesthesiology Section of theNational Institute of Dental Re-search's Oral Medicine and SurgeryBranch, is the recipient of the

1972 HeidbrinkAward.

This h i g h e s thonor given by theAmerican DentalSociety of Anes-thesiology is pre-sented annually toan individual whohas made a sig-nificant historical

Dr. Driscoll contribution to an-esthesiology in dentistry.

Dr. Driscoll received the awardat the Society's recent meeting inChicago.

He is recognized for his investi-gations in the physiology of dentalpatients receiving anesthesia of anambulatory basis and for hisleadership in assuring the safetyof modern anesthetic proceduresin dentistry.

Dr. Driscoll has also played akey role in the development andadministration of the new NIDRprogram in pain control.

He is a Diplomate of the Ameri-can Board of Oral Surgery, a mem-ber of the American Society ofOral Surgery, a Fellow of theAmerican College of Dentists, anda special consultant to the Councilon Dental Therapeutics of theAmerican Dental Association forAnesthesiology and Oral Surgery.

Dr. Driscoll also holds the covet-ed Horace Wells Club Award pre-sented in 1967.

developmental and consultativeservices on the selection of re-search models, research animalhousing and care, and techniquesof animal experimentation.

The branch—in Bethesda andat the NIH Animal Center inPoolesville, Md.—provides NIHresearchers with facilities for theconduct of experimental surgeryand the holding of research ani-mals.

It also serves as a repositoryfor animal strains with specialheritable characteristics fromwhich investigators throughoutthe world obtain breeding stock.

Dr. Brown Appointed to CouncilDr. Barbara Illingworth Brown,

research associate professor inthe Department of BiologicalChemistry at the WashingtonUniversity School of Medicine, St.Louis, has accepted membershipon the National Advisory GeneralMedical Sciences Council.

Dr. Brown's term will runthrough September 1974.