Faryal Mehwish Awan 1 Curriculum Vitae Faryal Mehwish Awan

Faryal Mehwish Awan Curriculum Vitae

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Faryal Mehwish Awan

HEC Approved PhD Supervisor

PhD (Applied Biosciences) (ASAB, NUST 2013-2018)

M.Phil. (Virology & Immunology) (ASAB, NUST 2010-2012)

Pharm-D (G.C University, Faisalabad 2005-2010)

+923465369713, +923335420034

Orcid.org/0000-0002-8146-8929

https://www.researchgate.net/profile/Faryal_Awan https://scholar.google.com/citations?user=jr2JuXMAAAAJ&hl=en

PUBLICATIONS Total International Journal Publications: 26

Conference Abstracts/ Full-Length Publications: 07

Book Chapters: 03

Impact Factor: 136.968

Citations: 1782 h-index: 17 i10-index: 19

CAREER OBJECTIVES

Aiming to make the best possible use of my technical expertise, acquired academic knowledge

and work experience in a research based career

ACADEMIC QUALIFICATIONS

From – Till Institution Degree Subject GPA/Grade

2013 – 2018 ASAB, NUST, Islamabad,

Pakistan/ University of

Toronto, Canada

PhD Applied

Biosciences

4.0

2010 – 2012 ASAB, NUST, Islamabad,

Pakistan

M.Phil. Virology &

Immunology

3.85

2005 – 2010 G.C University Faisalabad,

Pakistan

Doctor of

Pharmacy

(Pharm-D)

Pharmacy 3.42

2003-2005 F.G Degree College for

Women, Wah Cantt

HSSC Pre-Medical 75.72%

2001-2003 Sir Syed College, Wah Cantt SSC Science 80.82%

https://www.researchgate.net/profile/Faryal_Awan


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ACADEMIC DISTINCTION/AWARDS/HONORS

Merit Based Mega Science and Technology (S & T) Scholarship for M.Phil. leading to

PhD from NUST (2010-2015)

Award of scholarship under the International Research Support Initiative Program

(IRSIP) for University of Toronto, Canada (2015)

EXPERIENCE

Worked as an Assistant Professor, Institute of Molecular Biology and Biotechnology

(IMBB), the University of Lahore (September, 2019- July, 2020)

Currently working as an Assistant Professor, Department of Medical Lab Technology, the

University of Haripur (Joined August, 2020)

SYMPOSIUM/WORKSHOP:

Clinical Trial Monitoring Course, Govt. College University Faisalabad, Pakistan

(July, 2008)

Internship of Community Pharmacy at Care Pharmacy Faisalabad (Sep, 2008)

Internship in Quality Control and Quality Assurance Department, Sanofi Aventis,

Wah Cantt, Pakistan (2009)

Feb 11, 2011 1st Annual HCV Management Symposium 2011 at National

University of Sciences & Technology (NUST), Islamabad

International Pharmacy Conference and exhibition Marriott hotel, Islamabad (April,

2012)

April 02, 2013 International symposium on “Hepatitis B virus: emergence and

surveillance” at National University of Sciences & Technology, Islamabad

Seminar on Genetic Disorders: From Awareness to Diagnosis, ASAB, NUST,

Islamabad, Pakistan (Nov, 2014)

One Day International Nanomedicine Symposium “Nanotheranostics: A New

Concept in Imaging and Drugs Delivery”, Nuclear Medicine Oncology & Radiotherapy Institute, Islamabad, Pakistan

Symposium on Computer Aided Drug Design, Research Centre for Modeling &

simulation (RCMS), National University of Sciences & Technology, 27th Sep, 2017

Finalist in Finding Innovative and Creative Solutions for Society (FICS), NUST,

Islamabad, Pakistan (2015)

Three days workshop on “Statistical Package for Social Sciences” 28th-30th April, 2015 NUST, Islamabad, Pakistan

Two days workshop on “Data Analysis for Next Generation Sequencing (NGS)” 27th-28th March, 2019 COMSATS University, Islamabad, Pakistan

Organized seminar on Role of Students in Eradication of Corruption, The University of Haripur, Haripur, Pakistan (13th October, 2020)

Two days workshop on “Project Formulation” 10th -11th September, 2020 The

University of Haripur, Haripur, Pakistan

PUBLICATIONS

1. The emerging role and significance of circular RNAs in viral infections and

antiviral immune responses: possible implication as theranostic agents

Faryal Mehwish Awan*, Burton B. Yang, Anam Naz, Aneeqa Hanif, Aqsa Ikram,

Ayesha Obaid, Arif Malik, Hussnain Ahmed Janjua, Amjad Ali & Sumaira Sharif

(RNA Biology) July 2020 IF: 5.350

DOI: 10.1080/15476286.2020.1790198

2. MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in

sorafenib resistant hepatocellular carcinoma (HCC) cells reveals a strategy to

forestall drug resistance

Faryal Mehwish Awan, Anam Naz, Ayesha Obaid, Aqsa Ikram, Amjad Ali, Jamil

Ahmad, Abdul Khaliq Naveed & Hussnain Ahmed Janjua*

(Scientific Reports) Volume 7, September 2017 IF: 4.122

DOI: 10.1038/s41598-017-11943-1.

3. Identification of Circulating Biomarker Candidates for Hepatocellular

Carcinoma (HCC): An Integrated Prioritization Approach

Faryal Mehwish Awan, Anam Naz, Ayesha Obaid, Amjad Ali, Jamil Ahmad, Sadia

Anjum* & Hussnain Ahmed Janjua*

(PLOS ONE) Volume 10, September 2015 IF: 3.057


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DOI: 10.1371/journal.pone.0138913.

4. Mutation-Structure-Function Relationship Based Integrated Strategy Reveals

the Potential Impact of Deleterious Missense Mutations in Autophagy Related

Proteins on Hepatocellular Carcinoma (HCC): a Comprehensive Informatics

Approach

Faryal Mehwish Awan, Ayesha Obaid, Aqsa Ikram & Hussnain Ahmed Janjua*

(International Journal of Molecular Sciences) Volume 18, January 2017 IF: 3.687

DOI: 10.3390/ijms18010139.

5. In-silico analysis of claudin-5 reveals novel putative sites for post-translational

modifications: insights into potential molecular determinants of blood-brain

barrier breach during HIV-1 infiltration

Faryal Mehwish Awan, Sadia Anjum*, Ayesha Obaid, Amjad Ali, Rehan Zafar

Paracha & Hussnain Ahmed Janjua*

(Journal of Infection, genetics and evolution) Volume 27, October 2014 IF: 3.015

DOI: 10.1016/j.meegid.2014.07.022.

6. YAP circular RNA, circYap, attenuates cardiac fibrosis via binding with

tropomyosin-4 and gamma-actin decreasing actin polymerization

Nan Wu, Jindong Xu, William W Du, Xiangmin Li, Faryal Mehwish Awan, Feiya Li,

Sema Misir, Esra Eshaghi, Juanjuan Lyu, Le Zhou, Kaixuan Zeng, Aisha Adil, Sheng

Wang, and Burton B Yang*

(Molecular Therapy) Volume 29, March 2021 IF: 11.454

DOI: 10.1016/j.ymthe.2020.12.004.

7. The circular RNA circSka3 promotes invadopodia formation and breast cancer

progression

William W Du#, Weining Yang#, Xiangmin Li#, Ling Fang, Nan Wu, Feiya Li, Yu

Chen, Qihan He, Elizabeth Liu, Zhenguo Yang, Faryal Mehwish Awan, Mingyao Liu,

Burton B Yang*

(Molecular Therapy) Volume 28, May 2020 IF: 8.986

DOI: 10.1016/j.ymthe.2020.03.002

8. Designing a multi-epitope vaccine to combat emerging coronavirus disease 2019

(COVID-19) employing immuno-informatics approach


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Anam Naz*, Fatima Shahid, Tariq Tahir Butt, Faryal Mehwish Awan, Amjad Ali &

Arif Malik

(Frontiers in Immunology) July, 2020 IF: 5.085

DOI: 10.3389/fimmu.2020.01663

9. The circular RNA circ-Ccnb1 dissociates Ccnb1/Cdk1 complex suppressing cell

invasion and tumorigenesis

Ling Fang, William W. Du, Faryal Mehwish Awan, Jun Dong* & Burton B Yang*

(Cancer Letters) Volume 459, June 2019 IF: 7.360

DOI: 10.1016/j.canlet.2019.05.036.

10. A circular RNA circ-DNMT1 enhances breast cancer progression by activating

autophagy

William W Du, Weining Yang, Xiangmin Li, Faryal Mehwish Awan, Zhenguo Yang,

Ling Fang, Juanjuan Lyu, Feiya Li, Chun Peng, Sergey N. Krylov, Yizhen Xie, Yaou

Zhang, Chengyan He, Nan Wu, Chao Zhang, Mouna Sdiri, Jun Dong, Jian Ma, Chunqi

Gao, Steven Hibberd & Burton B Yang*

(Oncogene) July 2018 IF: 6.634

DOI: 10.1038/s41388-018-0369-y.

11. breast cancer progression by mutant p53 is inhibited by the circular RNA circ-

Ccnb1

Ling Fang, William W. Du, Juanjuan Lyu, Jun Dong, Chao Zhang, Weining Yang,

Alina He, Yat Sze Sheila Kwok, Jian Ma, Nan Wu, Feiya Li, Faryal Mehwish Awan,

Chengyan He, Bing L. Yang, Chun Peng, Helen J. MacKay, Albert J. Yee & Burton B.

Yang*

(Cell Death and Differentiation) May 2018 IF: 8.086

DOI: 10.1038/s41418-018-0115-6.

12. Structure-Function-Mutational Analysis and Prediction of the Potential Impact

of High Risk Non-Synonymous Single Nucleotide Polymorphism on Poliovirus

2A Protease Stability using Comprehensive Informatics Approaches

Amna Younus, Saba Munawar, Muhammad Faraz Bhatti*, Aqsa Ikram, Faryal

Mehwish Awan, Ishrat Jabeen, Nasar Virk, Hussnain Ahmed Janjua & Muhammad

Arshad


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(Genes) Volume 09, April 2018 IF: 3.331

DOI: 10.3390/genes9050228.

13. Model of the adaptive immune response system against HCV infection reveals

potential immunomodulatory agents for combination therapy.

Ayesha Obaid, Anam Naz, Aqsa Ikram, Faryal Mehwish Awan, Abida Raza, Jamil

Ahmad & Amjad Ali

(Scientific Reports) Volume 8, June 2018 IF: 4.011

DOI: 10.1038/s41598-018-27163-0.

14. Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

William W Du, Ling Fang, Weining Yang, Nan Wu, Faryal Mehwish Awan, Zhenguo

Yang & Burton B Yang*

(Cell Death and Differentiation) Volume 24, February 2017 IF: 8.000

DOI: 10.1038/cdd.2016.133.

15. A circular RNA promotes tumorigenesis by inducing c-myc nuclear

translocation

Qi Yang, William W Du, Nan Wu, Weining Yang, Faryal Mehwish Awan, Ling

Fang, Jian Ma, Xiangmin Li, Yan Zeng, Zhenguo Yang, Jun Dong, Azam Khorshidi

and Burton B Yang*

(Cell Death and Differentiation) Volume 24, September 2017 IF: 8.000

DOI: 10.1038/cdd.2017.86.

16. A circular RNA binds to and activates AKT phosphorylation and nuclear

localization reducing apoptosis and enhancing cardiac repair

Yan Zeng, William W. Du, Yingya Wu, Zhenguo Yang, Faryal Mehwish Awan,

Xiangmin Li, Weining Yang, Chao Zhang, Qi Yang, Albert Yee, Yu Chen, Fenghua

Yang, Huan Sun, Ren Huang, Ren-Ke Li, Zhongkai Wu, Peter H Backx & Burton B

Yang*

(Theranostics) Volume 7, August 2017 IF: 8.537

DOI:10.7150/thno.19764.

17. Identifying and characterizing circRNA-protein interaction

William W Du, Chao Zhang, Weining Yang, Tianqiao Yong, Faryal Mehwish Awan

& Burton B Yang*


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(Theranostics) Volume 7, September 2017 IF: 8.537

Doi: 10.7150/thno.21299.

18. The circular RNA circ-Amotl1 interacts with STAT3 increasing its nuclear

translocation and wound repair by modulating Dnmt3a and miR-17 function

Zhenguo Yang#, Faryal Mehwish Awan#, William W Du#, Yan Zeng#, Juanjuan Lyu,

Shaan Gupta, Weining Yang & Burton B Yang*

(Molecular Therapy) Volume 25, July 2017 IF: 7.008

DOI: 10.1016/j.ymthe.2017.05.022.

19. Identification of drug resistance and immune-driven variations in hepatitis C

virus (HCV) NS3/4A, NS5A and NS5B regions reveals a new approach toward

personalized medicine

Aqsa Ikram, Ayesha Obaid, Faryal Mehwish Awan, Rumeza Hanif, Anam Naz,

Rehan Zafar Paracha, Amjad Ali & Hussnain Ahmed Janjua*

(Antiviral Research) 2017 Jan; 137:112-124.IF: 4.307

DOI: 10.1016/j.antiviral.2016.10.013.

20. Petri Net-based model of Helicobacter pylori mediated disruption of tight junction

proteins in stomach lining during gastric carcinoma

Anam Naz, Ayesha Obaid, Faryal Mehwish Awan, Aqsa Ikram, Jamil Ahmad &

Amjad Ali*

(Frontiers in Microbiology) Volume 8, September 2017 I.F: 4.019

DOI: 10.3389/fmicb.2017.01682.

21. Pangenome and immuno-proteomics analysis of Acinetobacter baumannii strains

revealed the core peptide vaccine targets

Afreenish Hassan, Anam Naz, Ayesha Obaid, Rehan Zafar Paracha, Kanwal Naz, Faryal

Mehwish Awan, Syed Aun Muhammad, Hussnain Ahmed Janjua, Jamil Ahmad &

Amjad Ali*

(BMC Genomics) Volume 17, September 2016 IF: 3.729

DOI: 10.1186/s12864-016-2951-4.

22. Modeling and analysis of innate immune responses induced by the host cells

against hepatitis C virus infection.


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Ayesha Obaid, Jamil Ahmad, Anam Naz, Faryal Mehwish Awan, Rehan Zafar

Paracha, Samar Hayat Khan Tareen, Sadia Anjum, Abida Raza, Jan Baumbach &

Amjad Ali*

(Journal of Integrative Biology) Volume 7, May 2015 IF: 3.371

DOI: 10.1039/c4ib00285g.

23. Identification of putative vaccine candidates against Helicobacter pylori

exploiting exoproteome and secretome: A reverse vaccinology based approach

Anam Naz, Faryal Mehwish Awan, Ayesha Obaid, Syed Aun Muhammad, Rehan

Zafar Paracha, Jamil Ahmad & Amjad Ali*

(Journal of Infection, genetics and evolution) Volume 32, June 2015 IF: 2.591

DOI: 10.1016/j.meegid.2015.03.027.

24. Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit

multi-epitope vaccine against HCV utilizing immunoinformatics approaches

Aqsa Ikram, Tahreem Zaheer, Faryal Mehwish Awan, Ayesha Obaid, Anam Naz,

Rumeza Hanif, Rehan Zafar Paracha, Amjad Ali, Abdul Khaliq Naveed & Hussnain

Ahmed Janjua*

(Scientific Reports) Volume 8, October 2018 IF: 4.011

DOI: 10.1038/s41598-018-34254-5.

25. A multi-method and structure-based in silico vaccine designing against

Helicobacter pylori employing immuno-informatics approach

Anam Naz*, Tahreem Zaheer, Hamza Arshad Dar, Faryal Mehwish Awan, Ayesha

Obaid, Shifa Tariq Ashraf, Rehan Zafar Paracha, Arif Malik & Amjad Ali*

(Current Proteomics) April, 2020 IF: 0.680

DOI: 10.2174/1570164617999200414120231

26. Inhibitory Potential of Phytochemicals on Interleukin-6-Mediated T-Cell

Reduction in COVID-19 Patients: A Computational Approach

Arif Malik, Anam Naz*, Sajjad Ahmad, Mansoor Hafeez, Faryal Mehwish Awan,

Tassadaq Hussain Jafar, Ayesha Zahid, Aqsa Ikram, Bisma Rauff and Mubashir Hassan

(Bioinformatics and Biology Insights) Volume 15, June 2021 IF: 0


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DOI: 10.1177/11779322211021430.

CONFERENCE PAPERS/ ABSTRACTS

1. YAP circular RNA, circYAP, attenuates cardiac fibrosis via binding with

tropomyosin-4 and gamma-actin

Nan Wu, Sheng Wang, Yizhen Xie, William W Du, Xiangmin Li, Jindong Xu, Le

Zhou, Kaixuan Zeng, Faryal Mehwish Awan, Esra Eshaghi, Juanjuan Lyu & Burton B

Yang*

25th Canadian Connective Tissue Conference 2019, May 29-31, 2019

Shriners Hospitals for Children—Canada, Montreal, Quebec, Canada.

2. Evolutionary invariant drug Targets: In-silico Approach for the Identification of

Potential Drug Target Sites in Hepatitis C virus (HCV) proteins NS3/4A, NS5A

and NS5B.

Aqsa Ikram, Faryal Mehwish Awan, Ayesha Obaid, Anam Naz, Abdul Khaliq

Naveed & Hussnain Ahmed Janjua*

International Conference on Recent Advances in Medical and Health Sciences

(ICRAMHS), 2018. Rawalpindi, Pakistan 29th - 30th Mar.

3. Modelling of Adaptive and Innate Immune Responses and Identification of

Crosstalk Amongst Various Signaling Pathways Involved in HCV Infection Using

Systems Biology Approach.

Ayesha Obaid, Anam Naz, Faryal Mehwish Awan, Aqsa Ikram, Jamil Ahmad &

Amjad Ali*

ISERD International Conference, 2018. Rawalpindi, Pakistan 29th-30th January.

4. In-silico identification of novel bacterial antigenic proteins as potential vaccine

targets against gastric cancer using reverse vaccinology approaches.

Anam Naz, Faryal Mehwish Awan, Ayesha Obaid & Amjad Ali*

Anticancer research, 2014. int inst anticancer research editorial office 1st km

kapandritiou-kalamou rd kapandriti, po box 22, athens 19014, greece, 6079-6080.


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5. Mutational and Structural Analysis of HCV Non Structural Protein 2 (NS2)

Revealed Genotype Specific Motif in TMD3 of the Protein.

Sadia Anjum*, Faryal Mehwish Awan, Tahir Ahmad & Muhammad Sohail Afzal

International Journal of Bioscience, Biochemistry and Bioinformatics (IJBBB) 2013.

6. Towards understanding of H. pylori mediated tight junction dysfunction.

Anam Naz, Ayesha Obaid, Faryal Mehwish Awan, Aqsa Ikram & Amjad Ali

5th conference on biological and computational Sciences (C-BICS 2017), Islamabad

7. Model-based insights into the adaptive immune signaling against hepatitis C virus

infection: A systems-level approach.

Ayesha Obaid, Anam Naz, Faryal Mehwish Awan, Aqsa Ikram, Fatima Shahid &

Amjad Ali

5th conference on biological and computational Sciences (C-BICS 2017), Islamabad

BOOK CHAPTERS

1. Recent Advances and Challenges in microRNA-based Cancer Therapeutics.

Amjad Ali*, Faryal Mehwish Awan, Aqsa Ikram & Shifa Tariq Ashraf

Topics in Anti-Cancer Research, 6: 178-210. 2017

DOI: 10.2174/9781681084558117060010.

2 Formal modeling of the key determinants of Hepatitis C Virus (HCV) induced

adaptive immune response network: An integrative approach to map the cellular

and cytokine-mediated host immune regulations.

Ayesha Obaid, Anam Naz, Shifa Tariq Ashraf, Faryal Mehwish Awan, Aqsa Ikram,

Muhammad Tariq Saeed, Abida Raza, Jamil Ahmad & Amjad Ali.

Lecture Notes in Computer Science, Vol. 10963, 635-649, 2018. Publisher: Springer


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3. Systems-level understanding of single-cell omics.

Anam Naz, Ayesha Obaid, Aqsa Ikram, Faryal Mehwish Awan, Maryum Nisar,

Rehan Zafar Paracha & Amjad Ali

Single-cell Omics, Chapter 20, 2019. Publisher: Elsevier

As Journal Reviewer

Served as a reviewer for Autophagy Journal (Taylor & Francis Online) IF: 16.016

Served as a reviewer for Oncogene Journal (Nature) IF: 9.867

Served as a reviewer for the Journal of Molecular Therapy-Nucleic Acids (Cell Press)

IF: 8.886

Served as a reviewer for the Journal of Biomedicine & Pharmacotherapy (Elsevier) IF:

6.529

Served as a reviewer for the Journal of Frontiers in Oncology (Frontiers) IF: 6.244

Served as a reviewer for the Genomics Journal (Elsevier) IF: 5.736

Served as a reviewer for the Journal of Cancer Cell International (BMC: Part of Springer

Nature) IF: 5.722

Served as a reviewer for the Arabian Journal of Chemistry (Elsevier) IF: 5.165

Served as a reviewer for the Journal of Computers in Biology and Medicine (Elsevier) IF:

4.589

Served as a reviewer for the Journal of OncoTargets and Therapy (Dovepress) IF: 4.147

Served as a reviewer for Biomed Research International Journal (Hindawi) IF: 3.411

Served as a reviewer for the Journal of Medical Science Monitor (International Scientific

Information) IF: 2.649

Served as a reviewer for the Journal of Disease Markers (Hindawi) IF: 3.434

Served as a reviewer for the Journal of Heliyon (Elsevier)


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References

Dr. Burton B. Yang

Professor, Department of Laboratory Medicine and Pathobiology

Faculty of Medicine, University of Toronto

Senior Scientist, Sunnybrook Research Institute, Toronto, Canada

[email protected] ; [email protected]

+416-480-5874

Dr. Hussnain Ahmed Janjua

Associate Professor, ASAB, NUST

Department of Industrial Biotechnology, Atta-ur-Rahman School of Applied Biosciences,

National University of Sciences & Technology, H-12, Islamabad

Post Doctoral Research Fellow (CIBIO, UNITN, Italy, 2007-2011)

Post Doctoral Research Fellow (IMBM, UWC, South Africa, 2005-2007)

PhD (Imperial College London, UK, 200-2004)

[email protected] , +923235680231

Dr. Amjad Ali

Assistant Professor, ASAB, NUST

Department of Industrial Biotechnology, Atta-ur-Rahman School of Applied Biosciences,


[email protected] ; [email protected] ; [email protected]

+92-51-9085-6138 ; +92 333 9191903

Dr. Rumeza Hanif

Assistant Professor, ASAB, NUST

Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences,


[email protected], +92-51-9085-6155 ; +923339197603


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Faryal Mehwish Awan 1 Curriculum Vitae Faryal Mehwish Awan

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