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Established in 1992

f e l l o w s h i p i nA n t i - A g i n gR e g e n e R A t i v e &functionAl medicinecouRse completion guidelines & infoRmAtion

•Module I:AMetabolic,Anti-AgingandFunctionalApproachtoEndocrinology•Module II:AMetabolic,Anti-AgingandFunctionalApproachtotheTreatmentofHypertension,Diabetes,Coronary

ArteryDiseaseandMetabolicSyndrome•Module III:AMetabolic,Anti-AgingandFunctionalApproachtoGastroenterology,Neurotransmitters,andNeurology•Module IV:AMetabolicandAnti-AgingApproachtoAminoAcidandFattyAcidMetabolism,DrugInducedNutrient

Depletion,StemCellsandRegenerativeMedicine,SpiritualityandOsteoporosis•Module V:ClinicalIntensives•Module VI:HerbologyandTheFunctionalRegenerativeMatrix•Module VII:Mitochondropathy,HeavyMetalToxicities,AMetabolic,Anti-AgingandFunctionalApproachto

AutoimmuneDiseases,CognitionEnhancement,andFatigue•Module VIII:AMetabolic,Anti-AgingandFunctionalApproachtoPsychiatryandCancerTherapies,Nutritionandthe

Athlete,AMetabolicandFunctionalApproachtoLaboratoryEvaluations•Module IX:AMetabolicandFunctionApproachtoChildren’sHealth•Module X:HomeopathicApplicationstoMetabolicMedicine•Module XI:IVTherapies•Module XII:ToxicMetalsandFunctionalToxicology

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FellowshipinAnti-AgingRegenerativeMedicine(FAARM)

WhatisAnti-AgingMedicine?Anti-AgingMedicineisaclinical/medicalspecialtyinthefieldofscientificresearchaimedattheearlydetection,prevention,treatment,andreversalofage-relateddecline.Itiswelldocumentedbypeer-reviewedmedicalandscientificjournalsandemploysevidence-basedmethodologiestoconductpatientassessments.TheAmericanAcademyofAnti-AgingMedicinewasestablishedin1992asaprofessionalphysiciancertificationandreviewboard,whichoffersphysicianrecognitionintheformofspecialty-basedexaminationinAnti-AgingMedicine.Itrepresents20,000physicians,scientists,healthprofessionals,andthehealthmindedpublicfrom80countriesworldwide.

WhatisRegenerativeMedicine?RegenerativeMedicineoptimizesthebody’sendogenousmechanismsofself-repairandaddsprovenandnearfutureexogenoustreatmentsandtechnologies.Adultstemcellsappeartobeourmostpowerfultoolatthistime.Previousdogmaconcerningadultstemcellstaughtthatneuronsandmyocytesdidnothavestemcellsandthecellspresentatbirthjustdeclinedinquantityandquality.Itwasalsobelievedthathematopoieticstemcellsinthebonemarrowlackedplasticityandcouldnottransformtoothertissues.Currentmedicalliteratureprovesthatadultstemcellsexistinmosttissuesincludingbrain,heart,musclesandliver.Hematopoieticstemcells(HSC)andendothelialprogenitorcells(EPC)inthebonemarrowhaveplasticitytopotentiallytransformandrepairalltissuesandorgans. •InthehormoneoptimizationcomponentofAnti-AgingMedicinewearealreadyoptimizingstemcells.

Progesteroneviaitsmetaboliteallopregnenolonestimulatesneuralstemcells,testosteronestimulatesmusclestemcellsandEPC’swhichcanimproveerectilefunction,andgrowthhormonetreatmentforadultgrowthhormonedeficiencyimprovesthequantityandqualityofEPC’s.EstradiolimprovesincorporationandmobilizationofEPC’s.

•InthelifestylecomponentofAnti-AgingMedicineweareoptimizingouradultstemcellswithexerciseandcontrolofglucoseandinsulin.

•IntheneutraceuticalcomponentofAnti-AgingMedicineweareoptimizingouradultstemcellswithResveratrolasweturnongenessuchasSIR1andwithblueberry,greenteaandvitaminD3.DHAinomega3fishoilpromotesneurogenesisfromneuronalstemcells.

AnewphaseofRegenerativeMedicinehasrecentlycommencedwithcryogenicpreservationofadultstemcellsinhealthypatientsforfutureuse.Thesepatientsarethesamepro-activepopulationwhofollowAnti-Agingprograms.Afterstimulationwithgranulocytecolonystimulatingfactoradultstemcellscanbecollectedbyaphaeresisandstoredinseparatealiquotsfortreatmentofspecificpathologiessuchasacutemyocardialinfarctionorforoverallimmunesystemreconstitution.Thisparadigmshiftisreferredtoasbio-insurance.

WhatisFunctionalMedicine?FunctionalMedicineisanintegrative,science-basedhealthcareapproachthattreatsillnessandpromoteswellnessbyfocusingonthebio-chemicallyuniqueaspectsofeachpatient,andthenindividuallytailoringinterventionstorestorephysiological,psychological,andstructuralbalance.

FunctionalMedicinefocusesonunderstandingthefundamentalphysiologicalprocesses,theenvironmentalinputs,andthegeneticpredispositionsthatinfluencehealthanddiseasesothatinterventionsarefocusedontreatingthecauseoftheproblem,notjustmaskingthesymptoms.TherearesevenbasicprinciplesunderlyingFunctionalMedicinewhichincludethefollowing: •Science-basedmedicinethatconnectstheemergingresearchbasetoclinicalpractice. •Biochemicalindividualitybasedongeneticandenvironmentaluniqueness. •Patient-centeredcareratherthandisease-focusedtreatment. •Dynamicbalanceofinternalandexternalfactorsthataffecttotalfunctioning. •Web-likeinterconnectionsamongthebody'sphysiologicalprocessesalsoaffecteveryaspectoffunctionality. •Healthasapositivevitality,notmerelytheabsenceofdisease. •Promotionoforganreserve.

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LearningObjectives–ModuleI

ModuleIObjectives:A Metabolic, Anti-Aging and Functional Approach to EndocrinologyUponcompletionofthismodule,theparticipantwill: •Recognizethehormonalchangesthatwomenandmenmanifestwithaging •Discussthefunctionsofestrogen,progesterone,testosterone,andDHEAinthebody •Knowthestructureofthesexhormonesandtheirmetabolism •Understandtheintricatewebthatthehormonesareinthebody •Discusstherisksandbenefitsofestrogen,progesterone,testosterone,DHEA,pregnenoloneandmelatonin •Knowthesymptomsofestrogen,progesterone,testosterone,andDHEAloss •Learnthesymptomsofestrogen,progesterone,testosterone,andDHEAexcess •Understandthedifferencesbetweensyntheticandbio-identicalhormones •Reviewtheliteratureonsynthetic,bio-identicalhormonereplacement •Understandtheadrenalsystemanditsaffectsonothersexhormonesandhormonereplacement •Initiateorsuggesthormonereplacementtreatment •Understandreasonsbio-identicalhormonereplacementshouldbeconsidered •Monitortreatment,adjustdosages,alleviatesideeffectsofBHRT •Recognizetheclinicalmanifestationsofhypothyroidism •KnowthefactorsthatcausedecreasedproductionofT4,affect5'diodinaseproduction,causeaninabilityto convertT4toT3,andcausesassociatedwithdecreasedT3orincreasedreverseT3 •LearnfactorsthatincreasetheconversionofT4toT3 •Understandthecrucialrolethatiodinehasinthefunctionofthethyroidgland •Prescribeorsuggesttreatmentforhormonereplacementincludingcompoundedthyroidmedications •Reviewofthekeysignsandsymptomsofadrenalfatigue •Knowthephysicalexaminationfindingspresentinadrenalfatigue •Learnthelaboratorytestthataidinthediagnosisofadrenalfatigue •DiscusstheWomen’sHealthInitiativefindingsanditsclinicalimplications •UnderstandthelimitationsofserumtestingforsteroidhormonelevelsandFSH •Understandtheimportanceofmeasuringtissuelevelofhormones,indiagnosinghormonalimbalancesandin monitoringbio-identicalhormonereplacement •Understandtheimpactofstressonthebody •Understandthephysiologyofthestressresponse •Learnwhattestsbestmeasuresthephysiologicresponsetostress •Understandhowtoidentifyandtreatadrenaldysfunction •Understandhowstresseffectsthecardiovascularsystem,insulinresistance,immunedysfunction,neurotransmitter balance,hormonebalance,andthyroidfunction •Reviewinformationonsafeandeffectivetherapiestocorrectadrenaldysfunction •DiscussinnovativetestingthatidentifiesthyroiddysfunctionwhenTSHisnormal •Differentiatebetweenprogesteroneandsyntheticprogestinsrelatingtostructure,pharmacologicactionsandrisks •Explaintheliteratureconcerningtheriskofbreastcancerasitrelatestodifferencesinprogesteroneand syntheticprogestins •Explainresearchandclinicalstudiessuggestingthatprogesteronetherapyprotectsagainstbreastcancer •Discusstheadvantagesanddisadvantagesoftestinghormonelevelsindifferentbodyfluids •Discussthemethodologyofscientificsupportfor,andthedifferencesinsaliva,urineandbloodtestingof hormones •Presentscientificandclinicalstudiesthatsuggestconventionalvenipunctureserumtestingunderestimatestissue uptakeofsex-steroidsdeliveredtopically •Befamiliarwiththebasisofsteroidsynthesis

3

ModuleIObjectivesContinued •Understandtheurinemonitoringofhormonelevelsandmetabolites.Specificalgorithmswillbesharedtofacilitate easeofuseinclinicalpractice •Knowthehormonalchangesthatoccurwithaginginmales •Knowthecardiovascular,cognitive,bone,sexual,andemotionaleffectsofhormonedepletionandhormone restorationinmales •Learntomonitorandrestoreoptimalhormonelevelsinmales •Discussthedifferencesbetweencompoundingandmanufacturingmedications •Reviewthevariouslicensureneedstocompoundmedications •Discussthevariouspatientcareareasthatinvolvespecializedcompounding •Reviewvariousmedicationdosageformsthatcanbecompounded •Discussthevarioustypesofequipmentneededincompounding •Learnhowtoevaluateapatientforiodinedeficiency •Reviewtherolesiodineplaysinthebody •Discoverhowtotreatiodinedeficiency •RecognizethesymptomsofPMS •StudytreatmentmodalitiesforPMS •LearnthecriterionrequiredtomakethediagnosisofPCOS •LearnconventionalandmetabolictreatmentsforPCOS •Learnthedifferentbasesthathormonescanbeplacedinalongwiththeiradvantagesanddisadvantages

ModuleIIObjectives:A Metabolic, Anti-Aging and Functional Approach to the Treatment of Hypertension, Diabetes, Coronary Artery Disease and Metabolic SyndromeUponcompletionofthismodule,theparticipantwill: •Understandtheglycemicindexanditsuseindeterminingtheglycemicindexandglycemicloadoffoods •IdentifypatientswithSyndromeX/MetabolicSyndrome •Learnnutritionalsupplementsandlifestylerecommendationsfortreatmentofthecomponentsofmetabolic syndrome •Establishatreatmentcourseandtreatpatientswithinsulinresistance,diabetes,andneuropathy •Discussriskfactorsforheartdiseaseincludingelevatedcholesterol,triglycerides,lipidfractionation,homocysteine, lipoprotein(a),ferritin,fibrinogenandc-reactiveprotein •Lookatinterventionsforchronicendothelialinflammation •Understandtheroleofinflammationincardiovascularinflammatorydisease •Discussfreeradicalproduction,glycation,oxidationandapplytopatienttreatment •Understandthecausesofendothelialdysfunction •Knowbotanicaltreatmentstoaugmentthecareofinsulinresistantpatients •Evaluatethelinkbetweenoxidativestressandglycemiccontrol •Knowwhichlaboratoryteststoorderandtoproperlyevaluateinsulinresistance,diabetesmellitus,andriskfactors forheartdisease •Discusstheroleinsulinhasinthedevelopmentofhypertension •Learnnutritionaltreatmentsforhypertension •Learnlaboratoryevaluationstoaidinthediagnosisandtreatmentofheartdiseaseriskfactors •DescribeseveralinteractivemechanismsthattievariouscomponentsoftheMetabolicSyndromeand Cardiovasculardisease

LearningObjectives–ModulesItoII

4

ModuleIIObjectivesContinued •Reviewdiet,lifestyleandnutraceuticaloptionsforclinicallymanagingdyslipidemia,cardiovascularinflammation, homocysteine,insulinresistenceandrelatedconditions •Understandhowvariousnutrientdeficiencieslead/supportmetabolicsyndrome •Learnwhatlifestylefactorstomodifyinordertotreat/preventmetabolicsyndrome •Reviewthecompletephysiologyofhypertension •Examinemetabolicandanti-agingapproachestohypertensionthroughnutritionandsupplementation •Reviewcholesterolphysiologyanditscontributiontoatherosclerosis •Assessthecurrentliteratureondyslipidemia •Examineeffectivenutritionandnutritionalsupplementationstrategiesfordyslipidemia •Reviewamodelofcardiometabolicdisease •Accessthecurrentliteratureonthecomplexphysiologicrelationshipsunderlyingcardiometabolicdisease •Examineeffectivenutritionalstrategiesandnutritionalsupplementationoncardiometabolicdisease •Learnthedifferencebetweeninsulinsensitivity,insulinresistance,andTypeIIdiabetes •Understandglucosehomeostasis •Understandthecounter-regulatoryhormonesandhowtheirnormalfunctionscontribute/causeinsulinresistance •UnderstandwhyonlysomepatientswithinsulinresistancedevelopTypeIIdiabetes •RedirectthefocusofthetreatmentofTypeIIdiabetesfromtheinsulinperspectivetothepointofviewofthe counter-regulatoryhormones •Understandtheconsequencesofincreasedsugarintaketothebody •Learnthenumerousdiseasesthatarelinkedtoahighsugardiet •Discoverhiddensugars •Studysugarsubstitutes,theiruse,andpossiblesideeffects •Learnthesymptomsofreactivehypoglycemia •Knowthediseasesassociatedwithinsulinresistance •Learncausesofelevatedinsulinlevels •Learntheinterplaybetweenmetabolicsyndromeandpsychiatricillnesses •Understandthatmedicationsthatarecommonlyusedtotreatdepressionandothermentalhealthdiseasesmay increasethepatient'sriskofmetabolicsyndrome •Investigatehowtargetednutraceuticalscansupportcardiovascularfunction •Definetoxicbloodsyndromeanddiscussinterventionstoimprove •Identifytheinflammatoryindexandhowtoinvestigatesilentinflammation •Discusstheroleofenergymedicineinoptimumhealth •Listfivenutraceuticalsthatpromotefavorablevibrationalfrequenciesinthebody •Discusshowelectricalmedicineassistsinoptimizingcellularfunction •Definethecomplexroleofenergyandtheheart •Learnhowthenewtriadofbioenergeticenergyincardiachealth,i.e.,coenzymeQ10,L-carnitineandD-ribose canhelppreventandovercomeheartdisease •DiscoverwhyATPissoessentialinoptimizingdiastolicfunctionoftheheart •Learnaboutthemost20commontoxinsthatarefoundinoureverydaylife •Exploretherelationshipbetweenchemicaltoxins,inflammation,anddisease •Discovertherolethatheavymetalsplayinheartdisease

LearningObjectives–ModuleII

5

ModuleIIIObjectives:A Metabolic, Anti-Aging and Functional Approach to Gastroenterology, Neurotransmitters, and NeurologyUponcompletionofthismodule,theparticipantswill: •Learnnewtreatmentmodalitiesformultiplesclerosis,strokerecovery,Parkinson'sdisease,ALS,and Alzheimer'sdisease •Evaluatetheenergyproducingabilityofthemitochondriaandtheirroleinrevitalizingneurologicaltissue •Learnfactorsassociatedwithintestinalpermeability •Discusstheconsequencesofinflammationontheneurologicalsystem •Lookattheroleendocyticreceptors,scavengerreceptors,andRAGEshasontheinflammatoryresponse •Understandtheimportanceofthegastrointestinaltract'sroleintheimmunesystem •Understandthecrucialrolethatneurotransmittershaveinthebodyandhowtheyimpactvariousorgansystems •Learnthemanyreasonswhypatientshaveadifficulttimelosingweightandkeepingitoff •HaveacomprehensiveunderstandingoftherelationshipbetweentheGItractandneurotransmitterfunction •Evaluatetheroleofdietandantibioticsinthemanagementofgastrointestinaldysfunction •Demonstratetheuniquebiochemistryofindividualpatientsandexaminetheramificationsofnutrition, medications,andstressontheimmunesystemduringthefirstyearsoflife •Explainthegastro-intestinalsystem’sinterfacewiththeenvironment •Discusstheroleofnutritionanddigestioninthebalancingthegutflora,aswellastheroleofnutritionin gastrointestinaldisease •Identifythesymptomsanddiseasesassociatedwithyeastovergrowth •Learnthecausesofyeastovergrowth •Beknowledgeableaboutthetreatmentsofyeastovergrowth •Knowthesymptomsassociatedwithdysbiosis •Recognizesignsofpoordigestion •Knowthecausesofdysbiosis •Learnthecommonconditionsassociatedwithleakygutsyndrome •Learnthe4Rprogram •Determinethecommonsignsandsymptomsoflowgastricacidity •Knowthediseasesassociatedwithlowgastricacidity •LearntheprotocolforHCLacidsupplementation •Realizethesymptomsanddiseasesassociatedwithfoodallergy •Ascertainthesymptomsofpancreaticinsufficiency •Learnhowtoreplacebilesalts •Determinethesymptomsofbilesaltsdeficiency •Knowthecausesofgasandbloating •Learnthecausesofheartburn •Findoutnewtreatmentsforhiatalhernia •Learnthecausesofchronicdiarrhea •Learnthetreatmentofchronicdiarrhea

LearningObjectives–ModuleIII

6

ModuleIIIObjectivesContinued •Learnthecausesandtreatmentofhemorrhoids •LookattheriskfactorsforIBS •Learnthetreatmentforinflammatoryboweldisorders •Realizethesymptomsofacuteandchronicgallbladderproblems •Findouthowtotreatgallbladderdisease •Knowtheincidenceofceliacdisease •Understandtheincreasedmortalityassociatedwithceliacdisease •Understandthechangesthatoccurinthebowelwithceliacdisease •Learntestingmethodstoevaluateifapatienthasceliacdisease •Discoverthefalsepositivesandfalsenegativesthatcanoccurwithantibodytestingforceliacdisease •Recognizethereasonsforfalsepositiveresultsthatcanoccurwithbiopsywhenevaluatingapatientforceliacdisease •Learnaboutdermatitisherpetiformis •Knowtheextraintestinalmanifestationsthatcanoccurwithceliacdiseasebesidesdermatitisherpetiformis •Learntreatmentmethodsforallformsofceliacdisease •Recognizeotherautoimmunediseasesthatareassociatedwithceliacdisease •Knowthedifferentialdiagnosisforceliacdisease •Knowthedefinitionofprobiotics •Recognizethatgastrointestinalandvaginalflorachangewithage •Learnthemechanismofactionofprobiotics •Knowwhichbacteriathatoccurinthegastrointestinaltractthatarefriendlyandwhicharepathogens •Learnaboutbacteriocins •Learnthedesirablecharacteristicsofaneffectiveprobiotic •Recognizewhatfoodscanbeusedasprobiotics •Understandthebeneficialeffectsofnormalgutflora •Learnwhichdiseaseprocessescanbetreatedwithprobiotics •Learnthedifferentialdiagnosisofirritableboweldisease •Learntreatmentmodalitiesforirritableboweldisease •Understandwhatanallergyeliminationdietisandbeableusethistreatmentmodalitywithapatient •Learntheroleofprobioticsinthetreatmentofantibiotic-associateddiarrhea •Knowthedefinitionofprebiotics •Understandthecriteriatobeaprebiotic •Reviewthemedicalliteratureontheuseofprebiotics •Learnfoodsourcesofprebiotics •Recognizeprebioticsubstancesandtheorganismstheyworkon •Understandthatprotozoaninfectionsofthegastrointestinaltractmaybethecauseofunrecognizedsystemic illnesses •Learnconventionalandnaturaltherapiesforparasiticinfections •Knowtherolethatneurotransmittersplayinweightloss •Recognizetheimportanceofhormonalbalanceinweightloss •Understandthattheingestionoffoodsthatthepatientisallergictocancauseweightgain •Recognizetherolethatsleepdeprivationplaysinweightissues •Understandthatthebody’sabilitytoeffectivelydetoxifyalsoplaysaroleinweightgain •Learnthatweightgaincreatesaninflammatoryresponseinthebody •Knowthechemistrybehindwhysomefoodsareaddicting •Reviewthescientificliteratureonnutrientsthatcanaidinweightloss

LearningObjectives–ModuleIII

77

ModuleIIIObjectivesContinued •Knowtherolethatyeastovergrowthplaysinweightgain •Haveanunderstandingofbasicneurochemistryasitrelatestomoodandcognition •Recognizecommonneurotransmitterbalancesandhowtodiagnosethem •Discussthemajorneurotransmittersinbrainfunctionandtheirunderstoodrolesinbehaviorandinneurological disorders •Understandthefunctionofreceptorsforthesesubstancesandfactorswhichimpacttheirregulation •Discussthemetabolismofthesesubstanceswithinthebody,includingtheprecursorsandsubstratesnecessaryfor functioninthenervoussystemaswellashowtheyaremetabolizedinthebody •Understandthelimitationsofmeasurementoftheneurotransmittersandtherolethatthebloodbrainbarrierplays incontrollingaccessofsubstratesandcofactorstothebrain •Recognizecircumstanceswherefunctionalimagingtechniquesmayaidindiagnosisandtherapyofconditions relatedtoneurotransmitterdysfunction •Recognizesomeofthemanyinteractionsofneurotransmitterswithhormonalfunctionanddysfunction •RecognizetheparameterswithintheFunctionalMedicineMatrixthatwouldindicatetheneedforattentionto neurotransmitterfunctionandidentifycommonantecedents,triggersandmediatorswhenanimbalanceor dysfunctionissuspected •Learnmetabolicandanti-agingtreatmentoptionstoimprovemoodandcognition

ModuleIVObjectives::A Metabolic and Anti-Aging Approach to Amino Acid and Fatty Acid Metabolism, Drug Induced Nutrient Depletion, Stem Cells and Regenerative Medicine, Spirituality and OsteoporosisUponcompletionofthismodule,theparticipantswill: •Knowtheroleofnutritioninmaintainingoptimalhealthasthepatientages •LearnphaseIandphaseIIdetoxificationandtheconsequencesofthebody'sinabilitytodetoxify •Learnnutritionaldepletionscausedbymedications •Understandtherelationshipsamongthebiotransformationenzymesystems •Knowthecommonwarningsignsindicatingthattoxicitymaybeafactorforthepatient •Understandtherolesofphysical,psychological,andspiritualhealthinMetabolicandAnti-AgingMedicine •Knowessential,conditionallyessential,andnon-essentialaminoacidsandsymptomsofaminoaciddeficiencies •Learnnewtreatmentplansforosteoporosis •LookatpharmaceuticalinhibitorsofPhase1cytochromeP450enzymes •Learntreatmentmodalitiesforthedietaryandnutritionalsupportofdetoxification •Knowtheriskfactorsforosteoporosis •Lookatmetallothioneinsandgeneticpolymorphisms •Knowthefunctionoffattyacidsinthebody •Knowtreatmentsforaminoaciddeficiencies •Learndiseaseprocessthathaveaminoaciddeficienciesasanantecedent •Beawareofthediseasesthatcanbetreatedwithfattyacidreplacement •Understandthatfattyacidintakecanchangetheamountofmedicationthatapatientmayneed •TeachnewpaincontroloptionsusedinMetabolicandAnti-AgingMedicine •Understandfattyacidsmayhaveprofoundeffectsonthenetworkofinflammatorymediatorsalteringprostanoid synthesis,PPARactivity,andtheresponsetocytokines •Reviewthebasicconceptsbehindthedisciplinesofmetabolomicsandnutrigenomics

LearningObjectives–ModulesIII-IV

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ModuleIVObjectivesContinued •Definethecriticalstepsinvolvedinsignaltransductionandintracellularsignaling,withemphasison transmembranereceptors,intracellularkinases,transcriptionfactorsandDNAresponseelements •LearnhowDNAexpressioncanbemodifiedbyspecificdietaryandlifestylefactors •Identifythedifferencesbetweentypesofstemcells •Learnhowstemcellsareharvestedforautologoususe •Learnaboutthecurrentapplicationsofstemcellsfromliteraturereview •Identifyfutureapplicationsforautologousstemcells •Understandingofbasicpathophysiologyofthyroidmetabolismasitrelatestocardiacfunction •Evaluatethecurrentmythsregardingthyroidreplacementtherapy •Understandingofhowthyroiddeficiencycandirectlyrelatetocardiacdisease,hypertension,hyperlipidemia, arrhythmiaandheartfailure •Lookattherolethatgenomics,pharmacogenomics,proteomics,andnutrigenomicshasinMetabolicandAnti- AgingMedicine •Lookatapatient-centricsystemofhealthcarethataddressedbiochemicalindividualityandgeneticuniquenessto improvehealthandfunctionofthepatient •Understandtherelationshipsamongthebiotransformationenzymesystems •Teachtheparticipantthevalueofapreconceptionmedicalevaluation •Learnwhatteststoorderonapatientforapreconceptionmedicineevaluation •Aidtheparticipantintheinterpretationoflabsresultsinapreconceptionmedicineconsult •LearntheimportanceofEPA/DHAsupplementationuseinthemotherandhowitlateraffectsthehealthofher child •Studyimplementationmodalitiesforpatientswithfattyaciddeficiencies •Learnthesymptomsoftoxicbuildup •Discoverhowpatientsareexposedtotoxins •RealizewhatnutrientsaidinphaseIdetoxificationoftheliver •UnderstandthatatoxicmetabolitecanbuildupbetweenPhaseIandPhaseIIdetoxificationthatmaybemore toxicthantheoriginalmetabolite •LearnthesixphasesofPhaseIIdetoxification •AscertainhowtotreatapatientwithabnormalphaseIorphaseIIdetoxification •Explainhowaminoacidinsufficienciescanmanifestamongapopulationthatover-consumersdietaryprotein •Demonstrateexpertiseinstrategiesforplanningcorrectiveinterventionswithaminoacids •Explainhowfattyacidinsufficienciescanmanifestamongapopulationthatover-consumersdietaryfat •Explainthetypesoftoxicantsandtheirrespectivelevelsofhealththreats •Describemethodsofassessmentforxenotoxinexposuresandendotoxinburdens •Demonstrateexpertiseinstrategiesforplanningcorrectiveinterventionstoreducetoxinloadsandimprove detoxificationfunction •Attendeeswillachieveanexpandedawarenessofthecommonenvironmentaltoxinsandtheirimpactonthebody; thisawarenesscanthenbeusedtohelppatientsmakeinformeddecisionsabouthealthylifestylechoices •Attendeeswillgainaworkingknowledgeofthescientificevidencesupportingtheroleofenvironmentaland endogenoustoxinsininitiatingandperpetuatingchronicdiseaseandacceleratedaging;thisinformationcanthen beusedtoenhancethepractitioner’sdiagnosticskillsintherecognitionoftoxin-relateddisease •Attendeeswillgainanunderstandingofcurrentknowledgeregardingthebiotransformationandeliminationof environmentaltoxinsandthescientificbasissupportingtheuseofnutrientsandplant-derivedfactorsforenhancing theseprocessesasastrategyfortreatingtoxin-relateddiseaseandimprovingoverallhealth;practitionerswillbe abletousethisinformationtoexpandtheirtherapeuticrepertoire

LearningObjectives–ModuleIV

99

ModuleIVObjectivesContinued •Reviewthebasicconceptsbehindthedisciplinesofmetabolomicsandnutrigenomics •Definethecriticalstepsinvolvedinsignaltransductionandintracellularsignaling,withemphasison transmembranereceptors,intracellularkinases,transcriptionfactorsandDNAresponseelements •LearnhowDNAexpressioncanbemodifiedbyspecificdietaryandlifestylefactors •Identifyrisksassociatedwithnonpharmaceuticalgradefishoils •Identifyfutureapplicationsforautologousstemcells •BasicunderstandingofthepathophysiologyofVitaminD •KnowledgeoftheimplicationsofvitaminDdeficiency •LearnnewlabnormalsforVitaminD •Explainthesymptomsofthevariousheadachetypes •Identifynon-pharmacologicaltreatmentsforheadpain •DescribethemechanismofactionofButterburrinreducingthefrequencyofmigraine •Outlineatreatmentplanutilizingvarioustreatmentoptionsforthemigrainepatient •Reviewthepathophysiologyofperipheralpaintransmissionandthevariousreceptorsinvolved •Reviewtheuseoftopicalpainmedicationsandtherationaleforuse •Reviewvariousherbsandsupplementsthatcanhelpinthemanagementofthechronicpainpatient •KnowthemechanismsofhowVitaminKworksinthebody •LearntheformsofVitaminK •ReviewtheimportanceofVitaminKinvascularhealth •KnowthecausesofVitaminKdeficiency •UnderstandtheuseofVitaminKsupplementationinpatientstakingWarfarin

ModuleVObjectives:Clinical IntensivesUponcompletionofthismodule,theparticipantswill:

•ReviewhundredsofcasehistoriessothepractitionerleavestheModulewithacomprehensiveapproachonhowtotreatthepatientthenextdayfromaMetabolicandAnti-AgingMedicineapproach•Learnnewnutritionaltreatmentmodalitiesforosteoporosis,ADD/ADHD,allergies,asthma,anorexia,anxiety, arthritis,cancer,candidiasis,dysbiosis,Alzheimer'sdisease,hearthealth,closedheadinjury,URI,congestiveheartfailure,diabetesmellitus,neuropathy,depression,eyehealth,chronicfatiguesyndrome/fibromyalgia,energyenhancing,preventionofmigraineheadaches,lipidmanagement,hepatitisC,hypertension,IBS,Crohn'sdisease,ulcerativecolitis,immunebuilding,insomnia,restlesslegsyndrome,liverhealth,periodontaldisease,BPH,skin disorders,strokerecovery,sportsnutrition,stressreduction,hypothyroidism,hyperthyroidism,varicoseveins, weightloss,PMS,polycysticovariansyndrome,dysmenorrhea,cervicaldysplasia,woundhealing,andnutritionalneedsforvegetarians,andmuchmore

ModuleVIObjectives:Herbology and The Functional Regenerative MatrixUponcompletionofthismodule,theparticipantswill: •Learnthebotanicaltreatmentsofmanymajordiseaseprocesses •Knowthesideeffectsofbotanicalmedicines •Understandantecedents,triggers,andmediatorsofillness •Learntheinteractionthatherbsmayhavewithmedications •Understandandbeabletotreatinfectiousdiseasessuchashepatitisfromametabolicapproach

LearningObjectives–ModulesIV-VI

1010

ModuleVIObjectivesContinued •Learnfunctionalclinicalimbalancesthatcanoccurinthebody •Learnhownutritionaffectsgeneexpression •Reviewhistoryandtraditionalusesofcommonherbs •Reviewthemedicalliteratureonherbaltherapies •Definethefrontiersofresearchforbotanicalmedicines:identifykeyongoingquestionsregardingevidence-based effectiveness,consistencyofpreparationsandconcernsregardingsafety •Learntoutilizereadilyavailabledatabasestomakeinformedevidence-baseddecisionsregardingbotanical medicines •Gainanunderstandingoftherationaleandproposedmechanismsbehindthepotentialtherapeuticuseofselective herbalsupplementsforspecifichealthdisordersincludingchronicinflammation,immunedysfunctionandminor infections •Familiarizeparticipantswithextractionanddosageformsofherbaltherapies •FamiliarizeparticipantswiththeDSHEAactandlabeling •Havetheparticipantsunderstandandexplainstandardizationofherbalextractions •Educatetheparticipantsonwhatarethenecessaryrequirementsforaqualityherbalextraction •Haveparticipantslearnclinicalsynergisticeffectsofdrugtherapyandherbaltherapieswhereapplicable •Haveparticipantsbecomeawareofpotentialadverseinteractionswithdrug-herbprescribing •Haveparticipantsgainaworkingknowledgeofthedosingrequiredtogainatherapeuticendpointwithherbal remedies •Gainbasicunderstandingofthefunctionalmedicineprinciplesincludingthefunctionalmedicinetreeandmatrix •Identifythecoreclinical,functionalmedicineimbalanceswithexamples •Applythefunctionalmedicinematrixinaclinicalsettingwhenaddressingcomplexpatients •UnderstandtheimportancethatBvitaminsplayinthepreventionofdisease •LearnincasehistoryformatthesymptomsofalloftheBVitamindeficiencies •KnowthediseasesanddisordersthatcanbetreatedwithdifferentBVitamins •LearntheprevalenceofLymedisease •KnowthesignsandsymptomsofLymedisease •UnderstandthatLymediseasemaybeacontributingfactorforotherdiseases •DiscoverthetestingmethodstodiagnoseLymedisease •RealizethecommonlyusedantibioticstotreatLymedisease •LearnmetabolictherapiesforthetreatmentofLymedisease •Findoutco-infectionsthatmayoccurwithLymedisease •LearnaboutresistantLymedisease •Learnthehistoryofrestlesslegsyndrome •Knowthedefinitionofrestlesslegsyndromeversusthedefinitionofperiodiclimbmovementdisorder •Realizetheriskfactorsforthedevelopmentofrestlesslegsyndrome •Discoverthedifferencebetweentheprimaryandsecondarycausesofrestlesslegsyndrome •Knowthecoexistingdiseasesthatmayoccurwithrestlesslegsyndrome •Studythesymptomsofrestlesslegsyndrome •Knowthesymptomsofperiodiclimbmovementdisorder •Knowthefouressentialdiagnosticcriteriaforrestlesslegsyndrome •Findoutthelabstudiesthatneedtobeorderedtodiagnoserestlesslegsyndrome •Learnthedifferentialdiagnosisofrestlesslegsyndrome •Gainknowledgeofthedrugtherapiesthatareavailabletotreatrestlesslegsyndrome •Knowthedifferencebetweentoleranceandaugmentationinthetreatmentofrestlesslegsyndrome

LearningObjectives–ModuleVI

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ModuleVIObjectivesContinued •Ascertainthedifferenttreatmentsforintermittentrestlesslegsyndrome,dailyrestlesslegsyndrome,andrefractory restlesslegsyndrome •Learnnon-drugtherapiesforrestlesslegsyndrome •Recognizethatarthritisisoneofthemostcommondiseases •Knowtheradiologicfindingsseenonx-raytodiagnosisosteoarthritis •Findoutaboutthetwoformsofosteoarthritis •Understandconventionaltherapiesforosteoarthritis •Learnmetabolictherapiesforosteoarthritis •Knowcommonfoodsthatarelinkedtoallergiesandarthritis •Recognizethesideeffectsofdifferenttreatmentoptions •Learntreatmentoptionsforankylosingspondylitis •Knowthesymptomsofankylosingspondylitis •Identifyspecificplantandplantcompoundaseffectiveantivirals •Understandthemechanismofactionofspecificplantandplantcompoundsasantivirals •Becomeproficientinrecommendingplantandplantcompoundsforspecifichumanviruses •Identifybotanicalsthatareeffectiveforinfectiousdisease •Understandthemechanismofactionofspecificbotanicalsintheirabilitytomodulateinfectiousdisease •Becomeproficientinrecommendingbotanicalsforspecificinfectiousdiseases

ModuleVIIObjectives:Mitochondropathy, Heavy Metal Toxicities, A Metabolic, Anti-Aging and Functional Approach to Autoimmune Diseases, Cognition Enhancement, and FatigueUponcompletionofthismodule,theparticipantswill: •Understandthemoleculartriggersoftheimmuneresponseandtheirreceptors •Lookatintracellularsignalingpathwaysandtheirgeneproducts •Lookatthecellularandmolecularbiologyofimmunityandinflammation •Learnclinicalapproachestoimmuneimbalanceandinflammation •UnderstandthatmicronutrientinsufficiencyleadstoDNAandmitochondrialdamage •Lookatdisordersofmitochondrialfunction •Understandthenutritionalandenvironmentalregulationoftoxicmetals •Knowtherolethatheavymetaltoxicityplacesindisease •Recognizetherolethatexcitotoxinsplayonthedevelopingbrain •Learntreatmentplansonhelpapatientmaintaintheirmemory •Learnnewtreatmentmodalitiesforpatientswithmemoryloss •Learntherolethatexcitotoxinsplayindisease •Understandtheroleofantioxidantsincellularredoxcontrol •Recognizetheclinicalmanifestationsofchronicfatigueandfibromyalgia •Reviewtheroleofcytokinesasorganizersoftheinflammatoryresponse •Learnthecellularandmolecularbiologyofimmunityandinflammation •Lookatthemoleculartriggersoftheimmuneresponseandtheirreceptors •Understandthelossoftolerance,Th1/th2/Th3/Th4imbalanceandtheroleofnormalgutflora •Exploretheroleofalteredbioenergeticsinthediathesisofchronicdisease •Learnthecounter-regulatorycontrolpointsofimmuneimbalances •Approachtoautoimmunediseasesandcognitionenhancement •Defineanddifferentiatethevariousclinicalprofilesassociatedwithfatigue

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ModuleVIIObjectivesContinued •Understandkeybiochemicalfeaturesthatunderlieenergydeficitsinpatients •Understandfundamentaltoolsoflaboratoryassessmentinpatientswithfatigue •Createandunderstandingofthephysiologyoftheglutamatereceptorssystem •Demonstratehowtheimmunesysteminteractswithglutamatereceptorstoinducehumandisease •DiscussspecificCNSdiseasesandtheroleplayedbyglutamatereceptordysfunctioninthesediseases •Discusstheglutamatereceptorsysteminperipheraldisorders •Discusswaytoprotectthebrainandsystemicsystemfromglutamatereceptoroveractivity •Understandhowtomeasureallcomponentsofmemory,includingP300,WMS,CNSVSandotherrelatedfactors •Knowtheconnectionbetweenthebrain’stestingresultsandtheappropriatediagnosis •Learnhowtoapproachtreatmentformemorylossandhowtopreventit •Understandtoxicmetalexposurefromtheenvironment •Recognizethesymptomsandconditionsrelatedtotoxicmetalsexposure •Designaprotocolwithappropriatechelationagentsforheavymetaltoxicities •LearntheriskfactorsforAlzheimer’sdisease •Knowtheroleofheavymetalsinmemoryloss •Recognizetheeffectsoffluorideonthebrain •Understandtherolestressplaysoncognition •Knowtherolehormonalbalanceplaysinmemorymaintenance •Recognizetheaffectsofsugaroncognitivedecline •Learnnutrientsthatmayhelpmaintaincognition •Recognizemedicationsthatmayaffectmemory •Learnsymptomsofchronicmercurypoisoning •Examinetheresearchonthesafetyofmercuryamalgams •Lookatthediseasesrelatedtomercurypoisoning •Examinethediseasesaggravatedbyallergiestometals •Learnmechanismsofmercurytoxicity •Learnnutritionaldetoxificationmethodsformercurytoxicity •Examinesymptomimprovementafteramalgamremoval •Lookattherolethatenvironmentaltoxinsmayplayinautoimmunediseases •Knowmetabolic/anti-agingtreatmentsforlupus •Learnmetabolic/anti-agingtreatmentsforRaynaud’sphenomenon •Leanhownewdiagnostictestsforrheumatoidarthritis •Knowthedifferentialdiagnosisforhighanti-CCP •Knowmetabolic/anti-agingtreatmentsforrheumatoidarthritis •ExposedtonutrientsthataffectNF-KappaBeta •Learnhowtoevaluateandwork-upapatientwithchronicfatiguesyndrome(CFS)andfibromyalgia(FM) •RecognizethebrainimagingchangesthatoccurwithCFSandFM •RecognizetheautonomicandcardiacmanifestationsinCFSandFM •UnderstandtheimpairedmitochondrialfunctionthatoccursinCFSandFM •LearntheimmunedysfunctionthatispresentinCFSandFM •Recognizethesymptomsoffibromyalgia •Lookatconventionaltreatmentsoffibromyalgia •Learnthenumerousmetabolic/anti-agingtreatmentmodalitiesforfibromyalgia •Findoutthehowtotreatmitochondrialdysfunction •UnderstandtheroleGuaifenesinplaysinthetreatmentoffibromyalgia •UnderstandthatsalicylatesaffecttheefficacyofGuaifenesin •Learncommonmedicationsandnaturalproductsthatcontainsalicylates

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ModuleVIIObjectivesContinued •StudytheSHINprotocol •Discoverwhatphysicalmodalitiescanbeusedinthetreatmentoffibromyalgia •StudythedifferentialdiagnosisofCFS •LearnthefactorssuspectedofpromotingCFS •DiscoverimmuneabnormalitiesthatcanbepresentinCFS •RealizethenutritionaltreatmentsforCFS •UnderstandtherolethathypothyroidismandadrenalfatigueplayinCFSandFM •Reviewtheevolutioninthoughtregardingthepathophysiologyofautoimmunediseasesfromgenetically determined,staticdisordersofadaptiveimmunity(T&Blymphocytes)toadynamicprocessinvolvingdefective programmingofregulatoryandTh17lymphocytesbycellsoftheinnateimmunesystem(dendriticcells& macrophages) •Reviewthemechanismsbywhichinfections,imbalancesingutflora,foodantigens,toxins,andother environmentalfactorscantriggerthebreakdowninimmunetolerancethatleadstoautoimmunediseasein susceptibleindividuals •Explorethepracticalapplicationsofthismodelfordetectingautoimmunediseaseatanearlierstage,recognizing potentialenvironmentaltriggers,andmakingappropriaterecommendationsforlifestylechangesandnon- pharmaceuticalinterventions •Knowthedemographicsofautoimmunity •Understandsomeoftheimportantinteractionsoftheendocrinesystemwithimmunity •Learnhowtheendocrinesystemcanaffectautoimmunity •Knowseverallaboratorytestthatcanbeusedinadditiontothestandardtestsforautoimmunity •Knowthetreatmentoptionstoaugmentusualandcustomarytreatmentofautoimmunity

ModuleVIIIObjectives:A Metabolic, Anti-Aging and Functional Approach to Psychiatry and Cancer Therapies, Nutrition and the Athlete, A Metabolic and Functional Approach to Laboratory EvaluationsUponcompletionofthismodule,theparticipantwill: •Learnadvancedintegrativeapproachestocancertherapies •Exploreclinicalapproachestostructuralimbalances •Learnwhatdeterminestestresultaccuracy,sourcesoferrorandwhatisinvolvedinthemanagementofquality assurancesystemsinaclinicallaboratory •Understandhowreferencerangesareestablishedanddisplayed •Understandorganicacidmetabolismandhowthisrelatestoevaluatingnutrientinsufficiencyandtoxicimbalances •Learnhowtoevaluateapatient'slevelofoxidativestress •Understandhowurinaryporphyrinanalysiscanevaluatefunctionaleffectsofenvironmentaltoxins •Learnhowtoevaluateapatient'slevelofvitamins,minerals,andtoxicmetals •UnderstandtheuseandadvantagesofDNAidentificationofstoolmicrobes •Learntheuseofgenomicanalysisinthemanagementofpatienthealthrisks •Learnhowtoevaluatepatientlevelsofphthalatesandotherbioactiveplasticizersandhowthiscanaffectsteroid hormoneinteractionsandpotentialhealthrisks •Learnhowanalysisofstoolmicrobes,chemistry,immunologyandenzymologycanbeusedtoevaluateandtreat intestinaldisorders •KnowtreatmentsforpsychiatricillnessesfromanAnti-AgingandMetabolicapproach •Learnnutritionalsupportprogramsforthecompetitiveathlete •Learntherolethatnutrientsplayinthetreatmentofpsychiatricillness

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ModuleVIIIObjectivesContinued •Writeprescriptionsforexerciseplansforhealthypatientsandthosewithspecialneeds •LearnnewtreatmentmodalitiesintheareaofsportsmedicinefromaanAnti-AgingandMetabolicapproach •Learnhowtoweanapatientsuccessfullyoffofprescriptionmedicationssuchashypnoticsandantidepressants •Reviewthebiochemicalbasisofpsychiatricdiseases •Discusstheneurobiologyandchemistryofthesleepwakecycleinthecontextofcircadianrhythmsandidentify treatabledisordersthatcaninterruptrestorativesleep •Explaintheroleoftheorexinsecretingneuronsinsleepdisorders,includingnarcolepsy/cataplexy •Mapatreatmentorinterventionalplantooptimizerestorativesleep •Introducetheprinciplesoffunctionalmedicine,focusingonbiochemicalindividuality •Exploretherelationshipbetweengenesandenvironmentasriskfactorsfordisease,aswellasopportunitiesto optimizehealthandwell-being •Discusstheimportanceoflaboratorytestingthatemphasizesoptimalwellnessandlooksatfactorsthatchange beforetheoutwardmanifestationofdisease.Casehistorieswillbediscussed •Emphasizethefundamentalfunctionalimbalancesthateveryclinicianshouldconsiderwhenseeingapatient: environmentalinputs,immune&inflammatoryimbalance,energyproduction/oxidativestress,gastro-intestinal imbalance,detoxification&biotransformation,hormonal&neurotransmitterimbalance,structuralimbalance,and emotionalimbalance •Applythenew-foundunderstandingthegene-environmentinteractioninclinicalpractice •Understandthereasonsforthefailureoftraditionalchemotherapy •Learnhowtousetargetedchemotherapy •Learnnewprotocolsforadvancedstagecancers •Haveabasicunderstandingofhowclinicallabtestsarerun •Learnwhatdeterminesresultaccuracy,sourcesoferrorandwhat’sinvolvedinmanagementofqualityassurance systemsinaclinicallaboratory •Understandhowreferencerangesareestablishedanddisplayed •Learnhowtodetectandtreatfoodallergiesandhowthiscanaffecthealth •Understandhowtoevaluateapatient’slevelofvitamins,mineralsandtoxicmetals •Understandorganicacidmetabolismandhowthisrelatestoevaluatingnutrientinsufficiencyandtoxicimbalances •Learnhowanalysisofstoolmicrobes,chemistry,immunologyandenzymologycanbeusedtoevaluateandtreat intestinaldisorders •UnderstandtheuseandadvantagesofDNAidentificationofstoolmicrobes •Learnhowanaerobicbacterialimbalancesinthegutcanaffecthealthandtreatments •Learntheuseofgenomicanalysisinthemanagementofpatienthealthrisks •Learnhowtoevaluatepatientlevelsofphthalatesandotherbioactiveplasticizers,howthiscanaffectsteroid hormoneinteractionsandpotentialhealthrisks •Recommendappropriatemineralandvitaminrepletionbasedonexerciseneeds •Recommendthecorrectproteintocarbohydrateratiosandspecificsourcestooptimizenutrienttimingdepending onage •Recommendaminoacidsthatareevidencedbasedtoimproverecoveryfromastrenuousexerciseprogram •Recommendnutraceuticalsandherbalcompoundsthatwillreducelactateloadingandreperfusioninjury •Recommendtheappropriatenutrientstosupportinflammationandpostsurgeryrecovery •Investigatetherolethatdiethasincancerprevention •Providetheexistingandnewresearchonmetabolictherapiesforthetreatmentofcancer •Identifyscientificrationaleforusingantioxidant/micronutrient/phytochemicalcombinationswithstandard conventionalcancertherapies

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ModuleVIIIObjectivesContinued •Providesupportingliteratureconcerningnutriceuticalsandiftheycanbeusedascomplementingcancertherapies •Addressalternativetreatmentofspecificcancertypes •Learntherapiesthatmaypreventortreatthesideeffectsofradiationorchemotherapy •Providestep-by-stepguidetothesafeandgradualwithdrawalfromtranquilizers,antidepressants,andsleepingaids •Identifythesymptomsofanti-depressantandhypnoticmedicationwithdrawal •Learnnutritionalsupportforbenzodiazepinewithdrawal •Learntheeffectsthatanti-depressantshaveonthebrain •LearnnutritionalsupportfordiscontinuationofSSRIs,tricyclicandMAOinhibitoranti-depressants •Learnnutritionalsupportforhypnoticwithdrawal •Knowtheantidepressant-inducedmental,behavioral,andcerebralabnormalitiesthatcanoccurwiththeiruse •Learnmetabolictreatmentsfordepression,anxiety,OCD,schizophrenia,andmanicdepression •Recognizethebiochemicalimbalancesthatresultinamentalillness •Understandthedeclineinendocrinefunctionthatoccursinallorganswithage •Knowthebehavioraleffectsofendocrinedisordersandtheirapplicationtogeriatricpsychiatry •Leanlaboratoryabnormalitiesthatoccurwithhyperparathyroidism •LearnthemechanismsofactionofPTH •Recognizethedrugeffectsthatoccuronbonestrength •UnderstandhowthemodeofdeliveryofPTHdeterminestheskeletalresponsetoPTH •ReviewtheliteratureontheeffectPTHtreatmenthasontheriskofvertebralfracturesinpostmenopausalwomen withosteoporosis

ModuleIX:Objectives:A Metabolic and Function Approach to Children’s HealthUponcompletionofthismodule,theparticipantwill: •Understandthatthehealthofthemotherwhensheispregnantgreatlyimpactsthehealthofthechild •Reviewtheliteratureonmetabolicapproachestoprenatalhealth •LearnantecedentsandmediatorsthataffectthedevelopmentofADD/ADHD •LearnnutrientsthathavebeenshowninmedicaltrialstoaidinthetreatmentofADD/ADHD •UnderstandtheimportancethatgastrointestinalhealthplaysinADD/ADHD •LearnthesideeffectsofconventionaltreatmentsforADD/ADHD •RecognizethebehaviorsandsymptomsofachildwithAutismSpectrumDisorder(ASD) •LearnthecommonfactorspresentinASDchildren •DiscoverlaboratoryprofilestoidentifyuniquetreatmentoptionsavailableforASD •Reviewtheliteratureonthehistoryofvaccinations •UnderstandtherolethatdetoxificationplaysinASD •RecognizetheroleoxidativestressplaysinASD •LookatmicroglialactivationinASD •AscertainthepossibleroleallergiesmayplayinASD •LookatnutritionalsupplementationthathasbeenfoundsuccessfulintheliteratureinthetreatmentofASD •Reviewanewstudyonhyperbarictreatmentforchildrenwithautism •Lookattheroleofantibioticuseinchildren •Learnherbaltherapiesthatmayfunctionasantibiotics •Reviewthecurrentstatisticsonchildhoodobesity •Gathernewinformationonmetabolicmodalitiestotreatandpreventchildhoodobesity •Reviewametabolicapproachtothetreatmentofchildhoodallergies •Realizethatinsulinresistancemaybegininchildhood •Understandtherolethatexerciseplaysinoverallhealthinchildhood •Learnmetabolicapproachesforthetreatmentofinfections

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ModuleIXObjectivesContinued •Knowdetoxificationtherapiesforchildren •Learntreatmentmodalitiesforteenswithaggressivebehaviors •Recognizetheroledietplaysinthepsychologicalhealthofachild •Learnmetabolictreatmentsforchildhooddepression •Understandtheimportanceofbowelhealthinachild •Learnmetabolicandfunctionaltreatmentsforasthma •Knowmetabolictherapiesforlearningdisabilities

ModuleX:Objectives:Homeopathic Applications to Metabolic MedicineUponcompletionofthismodule,theparticipantwill: •Gainanunderstandingofhistoricaldevelopmentofhomeopathy •Understandtheconceptofhomeopathicpharmacology •DefinethelegalstatusandprescribingrightsofhomeopathicmedicinesinregardstoOTCandRXstatus •Describethenomenclatureforhomeopathicmedicinedoses •Reviewhomeopathicmedicinemanufacturingandtheprocessofsuccession •DescribethedifferencesbetweenaMateriaMedicaandRepertory •Familiarizethestudentswiththethoughtprocessandrationaleforselectionofhomeopathicmedicines •ProvideafoundationforunderstandingConstitutional,ComplexandClinicalhomeopathicprescribing •Provideaframeworkforstudentstoselecthomeopathicmedicinesasapartoftheintegrativemodelforhealthcare •Educatethestudentonhomeopathicmedicinedosingforcommoncomplaintssuchasarthritis,headaches, migraines,sinusitis,allergiesandothercommonchroniccomplaints •Educatethestudentonhomeopathicmedicinesformoreacuteconditionssuchassorethroat,colds,fluand adjunctivesupportfortraditionalmedicines •EducatethestudentonhomeopathicmedicinedosingandapplicationoftopicalandoralandInjectableformsofhomeopathicforthemanagementofsofttissueinjury,reactivationofmetabolismandenhancementof detoxificationpathways •Familiarizethestudentwithhomeopathicmedicinedosingandselectionforcommoncold&fluandallergy complaints •FamiliarizethestudentwithhomeopathicmedicinedosingandselectionforcommonGIcomplaintssuchas diarrheaandconstipation •Familiarizethestudentwithhomeopathicmedicinedosingandselectionforupperrespiratoryconditionssuchas cough,sinusitis,andmucolyticsupport •Familiarizethestudentwithhomeopathicmedicineandselectionforbehaviorissues,nightterrorsandbedwetting •Familiarizethestudentwithhomeopathicmedicinedosingandselectionforcommonbumps,bruisesandscrapes •Familiarizethestudentwiththetheoryandresearchrelatedtohomotoxicolgy •Familiarizeandgainaworkingknowledgeofthesixphaseprocessofchronicillnessandthedefinitionofeachof thephases •Familiarizethestudentontheimmunitymodelforhomeopathicmedicine •Teachthestudenttoapplyhomotoxicologicpreparationsforrecouplingofoxidativephosphorylationandretarding thechronicinflammatorycascade •Teachthestudentapplicationofhomotoxicologyinthegeriatricpopulation •Introducetheconceptofgemmotherapytothestudent •Provideaworkingknowledgeofdosageandapplicationofgemmotherapymedicinessothatthestudentcanapply thisinformationclinically •Introducetheconceptofdiathesisandthetheorybehindoligotherapy •Provideaworkingknowledgeofdosage,protocolandapplicationofoligotherapysothatthestudentcanapply thisinformationclinically

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ModuleXI:Objectives:IV TherapiesUponcompletionofthismodule,theparticipantwill: •Learnprework-upevaluationsofIVtherapypatients •KnowwhentouseIVtherapies •LearnhowtosetupanofficetodoIVtherapies •LearnsafetyprotocolsforIVtherapies •LearnhowtofollowapatientduringIVtherapytreatment •RecognizesideeffectsofIVtherapies •LearnIVprotocolsformedicalconditions •LearnIVchelationtherapiesforheavymetaltoxicities •Learnoralandrectalchelationtherapies •Understandthesideeffectsofchelation •LearnIVprotocolsfornutritionaltherapies •KnowIVtherapiesforinfectiousdiseases

ModuleXII:Objectives:Toxic Metals and Functional Toxicology

Uponcompletionofthismodule,theparticipantwill:•Learnhowtoassessapatientfortoxicmetalexposure•Lookattheincidenceofexposuretotoxicmetals•DiscovertreatmentmodalitiesforretentionoftoxicmetalsincludingEDTA,DMPS,DMSA•Learnnonpharmaceuticalagentsthatchelateoutheavymetals•Understandtheimportanceofadequatemineralstatusbeforetestingapatientforheavymetaltoxicity•Learnthesymptomsofheavymetalexposure•Studythecommontoxinsthataffecthealthincludingorganohalogens,organophosphates,organicsolvents,and

heavymetals•Knowthemechanismsoftoxicinjuryincludingdisturbancesincellsignaling,alterationsinstructuralentitiessuchas

themitochondria,andimpairedsynthesisofspecificmoleculessuchasfattyacids,proteins,nucleotides,glutathione,andphospholipids

•Discoverhormonaldisruptionthatcanoccurwithtoxinexposure•Understandthebiotransformationthatcanoccurwithdrugs,metals,andxenobioticsbeforetheyareexcretedfrom

thebody•FindouthowbiotransformationbycytochromeP-450enzymesaffectsthetoxicnatureofcompounds•Studythemechanismofoxidativestresscausedbytoxins•Learnaboutdetoxifyingenzymesandgeneticpolymorphism•Knowaboutmetallothioneinsandgeneticpolymorphism•Discovernutritionalandenvironmentalfactorsthatmodifysusceptibilitytoenvironmentaltoxins•Learnhowtoassessthetoxicologicallyaffectedpatient•Gatherinformationonhowtoteachapatienthowtohaveadetoxifiedlifestyle•Discoverthefiveorgansofdetoxificationinthebodyandhowtoaidapatientindetoxifyingtheseorgans

Master'sProgramThemodulesintheFellowshipinAnti-Aging,Regenerative,andFunctionalMedicinehavealsobeenapprovedforcoursecreditattheUniversityofSouthFloridaSchoolofMedicineleadingtoamaster’sdegreeinMedicalScienceswithaconcentrationinMetabolicandNutritionalMedicine.Forfurtherinformationonenrollinginthemaster’sprogramandcourserequirementscontactElizabethWheelerat561-997-0112ext.531.

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FellowshipDirectorPamela Wartian Smith, M.D., MPH,spentherfirsttwentyyearsofpracticeasanemergencyroomphysicianwiththeDetroitMedicalCenter.SheisadiplomatoftheBoardoftheAmericanAcademyofAnti-AgingPhysiciansandisaninternationallyknownspeakerandauthoronthesubjectofMetabolic,Anti-AgingandFunctionalMedicine.ShehasbeenfeaturedonCNN,PBS,andothertelevisionchannels,radioshowsandconsumermagazines.SheiscurrentlytheDirectoroftheCenterforHealthyLivingandLongevityandthefounderandDirectorofTheFellowshipinMetabolic,Anti-AgingandFunctionalMedicine.Sheistheauthoroffourbest-sellingbooks,"HRT:TheAnswers,""Vitamins:HypeorHope,""DemystifyingWeightLoss","WhatYouMustKnowAboutVitamins,Minerals,Herbs&More,"andhernewbook"WhatYouMustKnowAboutWomen'sHormones,"hasjustbeenreleased.

Thomas J. Barnard, M.D., FCCFP, (EM), FAAFP, CAQ, (Geriatrics),FABAAM,adjunctclinicalprofessoroffamilymedicine,UniversityofWesternOntario,adjunctprofessorofHumanBiologyandNutritionalSciences,UniversityofGuelph.ConsultantandMedicalDirector,AuraMedicalRestorativeSpa,Leamington,OntarioCanada,2006.ChiefScientificOfficer,SeeYourselfWell,Inc,1999topresent.AuthorofDefeatingDiabetesPublished2003.

Scott Becker, M.D., istheMedicalDirectorofTheBeckerHiltonMedicalInstituteinFortLauderdale,Florida.HehasbeeninPediatric&AdolescentMedicinefor18years,aswellasaPediatricEmergencyRoomAttendinginsomeofFlorida’shighestacuityandbusiestPediatricER’soverthesametime.

Russell L. Blaylock, M.D., CCN,didhisresidencyinneurosurgeryattheUniversityofSouthCarolinaSchoolofMedicine,isontheeditorialboardoftheJournalofAmericanPhysiciansandSurgeonsandhasauthoredseveralbooksincluding:Excitotoxins:TheTasteThatKills,HealthandNutritionSecretsThatCanSaveYourLife,andNaturalStrategiesforCancerPatients.Heiswellpublishedinthemedicalarenawithnumerousjournalarticles.

Kenneth A. Bock, M.D., FAAFP, FACN, CNS,receivedhismedicaldegreewithHonorin1979.HeistheauthorofHealingtheNewChildhoodEpidemics:Autism,ADHD,Asthma,andAllergies.Forthepast25years,hehasdealtwithcomplexmedicalproblemsbyintegratingalternativemodalitieswithconventionalmedicineintoacomprehensiveintegrativemedicalpractice

J. Alexander Bralley, Ph.D.,hasauthorednumerousresearchpublications,isanInternationallyknownspeakerandco-author/editorofthelandmarktextbook,LaboratoryEvaluationsforIntegrativeandFunctionalMedicine,nowinits2ndedition,andisfounderandCEOofMetametrixClinicalLaboratory.

Eric R. Braverman, M.D.,istheDirectorofThePlaceforAchievingTotalHealth(PATH)Medical,NewYorkCity,NY,afull-servicefamilyhealthcareintegrativemedicalpractice.HealsoisPresidentofTotalHealthNutrientsandauthorofseveralbooks.

Ben Brown, M.D.,istheDirectoroftheIntegrativeMedicineFamilyMedicineResidencyattheUniversityofCaliforniaSanFrancisco.HeisalsotheDirectorofGlobalMedicineattheUniversity.Dr.Brownfurthermorespent15yearsneartheThai-Burmaborderoninternationalmedicalmissionswork.HestudiedunderDr.DeanOrnishandhaswonnumerousawardsasateacher,authorandlecturer.

Mitchell J. Ghen, D.O., Ph.D.,has30yearsofIntegrativeMedicalexperience.HeisoneofthePioneersofI.V.NutritionalTherapiesandhastaughttheworkshopsonthesubjectfortheA4M.Authorof3textbooks,dozensofarticles,includingthestudyguidechapteronRegenerativeMedicineandaradiotalkshowhost.

George Gillson, M.D., Ph.D.,receivedaPh.D.fromUniversityofAlbertabeforeearninghisM.D.fromUniversityofCalgary.HepracticedFamilyMedicineforsixyearsandisnowthePresidentandMedicalDirectorOfRockyMountainAnalyticalLaboratoryinAlbertaCanada.Heistheco-authorof“You’veHitMenopause,NowWhat?”

Thomas Guilliams, Ph.D.,isDirectorofthePointInstituteofNutraceuticalResearch,researcharmofOrthoMolecularProducts,whereheservesastheVP/DirectorofScienceandRegulatoryAffairs.HeisalsoaclinicalinstructorfortheUW-MadisonSchoolofPharmacy.Hisfocusisontheevidence-basedapproachofNutraceuticals.

Patrick Hanaway, M.D.,foundedFamilytoFamily:YourHomeforWholeFamilyHealthinAsheville,NC,andiscurrentlyMedicalDirectorforGenovaDiagnostics.Dr.HanawayhaslecturedextensivelyacrosstheUSandinEuropeontheclinicalapplicationofnutritionandgenomics,particularlyintheareasofdigestion,oxidativestress,inflammation,andachievinglong-termwellness.

Andrew Heyman, M.D., MHSA,isanationallyknownexpertinnaturaltherapies.HecurrentlysitsastheclinicalchairoftheConsortiumofAcademicHealthCentersforIntegrativeMedicineandisonfacultyattheUniversityofMichiganintheDepartmentofFamilyMedicine.

Mark Houston, M.D., SCH, FACP, FAAHA,isassociateclinicalprofessorofclinicalmedicineatVanderbiltUniversitySchoolofMedicineandDirectorofahypertensioninstituteinNashville,TN.Hehaspublishedover120peer-reviewedmedicalarticles,threebooks,andnumeroustextbookchapters.

Jerry Kartzinel, M.D.,isaBoardCertifiedpediatricianandaFellowintheAmericanAcademyofPediatrics.Hespecializesintherecoveryofneurodevelopmental,chronicneuro-inflammatorydiseases,andhormonaldysfunctions.HispracticeislocatedinIrvine,California.

FellowshipStaffandFaculty

Faculty

Lisa Saff Koche, M.D.,isaninternistwithboardcertificationinbothbariatricsandinternalmedicineandisFellowshipTrainedinAnti-AgingandRegenerativeMedicine.SheisanAssociateProfessorattheUniversityofSouthFloridaandtheDirectorofCardiacRehabatTampaGeneralHospital.SheisalsotheMedicalDirectorofSpectraHealthcare.Dr.Kocheoftenisfeaturedontelevision,hasfrequentlybeenpublished,andlecturesontopicsofwellness,hormones,thyroiddisease,nutritionandweightloss.

Jim LaValle, R.Ph., C.C.N., N.D.,has18+yearsofclinicalpracticeexperienceinthefieldofnaturaltherapeuticsandfunctionalmedicine,isauthorof14books,thelatestbeing“CrackingTheMetabolicCode”andisanadjunctprofessorintheCollegeofPharmacy,UniversityofCincinnati.

Jay Lombard, D.O.,istheChiefofNeurologyatBronxLebanonHospital.Inadditiontohisclinicalduties,heisanAssociateProfessorofNeurologyandPharmacologyatTouroMedicalCollege,AssistantProfessorofNeurologyatCornellMedicalSchoolandaClinicalInstructorofNeurologyatAlbertEinsteinCollegeofMedicine.Heistheauthorofseveralcriticallyacclaimedbooks,includingtherecentlypublishedwork;"FreedomfromDisease."

Richard Lord, Ph.D.,completedhisdegreeinChemistryattheUniversityofTexas.HethenwentontodoafellowshipattheNIHandsubsequentlywastheChairmanoftheDepartmentofChemistryatLifeUniversity.HeiscurrentlytheChiefScienceOfficeratMetametrixLaboratory.Hehasnumerouspublishedarticlesinscientificmagazinestohiscreditalongwithauthoringtwotextbooks.

Mark Rosenberg, M.D.,isBoardCertifiedinemergencymedicineandisactiveindrugresearch.Hehasrecentlypatentedadrugforthetreatmentofobesitythatwillsoonbeenteringclinicaltrials.Overthepastthreeyears,Dr.Rosenberghasdevelopedandrefinedanovelprotocolforthetreatmentofadvancedcancer.

Ron Rothenberg, M.D., isClinicalProfessorandCourseDirectorofPreventativeandFamilyMedicine,UniversityofCalifornia,SanDiegoSchoolofMedicine.HeistheauthorofForeverAgelessandhasrecentlybeenfeaturedintheUniversityofCaliforniaM.D.televisionseries.

Robert Rountree, M.D.,practicesfamilymedicineinBoulder,CO,isboardcertified,andisanadjunctclinicalfacultyoftheInstituteforFunctionalMedicineinWashington.HeisalsoaDiplomatoftheAmericanBoardofHolisticMedicine,andisco-authorofnumerousbooksincluding:TheNewBreastfeedingDiet(McGraw-Hill,inpress),andANaturalGuidetoPregnancyandPostpartumHealth(Avery,2002).

Michael A. Schmidt, Ph.D.,didhisPh.D.researchinmolecularmedicinewithintheLifeSciencesDivisionatNASAAmesResearchCenter.HeisamemberoftheSocietyforNeuroscienceandtheMetabolomicsSociety.HeistheauthorofBrain-BuildingNutritionandofBeyondAntibiotics:StrategiesforLivinginaWorldofEmergingInfections&Antibiotic-ResistantBacteria(2009).

Stephen T. Sinatra, M.D., F.A.C., C.M.S.,isAssistantClinicalProfessorofMedicineatUniversityofConnecticutSchoolofMedicine.HeisboardcertifiedinCardiologyandInternalMedicine,andistheformerChiefofCardiologyatManchesterMemorialHospital.Hehasauthoredseveralbooks,includingLosetoWin,HeartbreakandHeartDisease,OptimumHealth,andTheCoenzymeQ10Phenomenon.

Alicia Stanton, M.D.,receivedherdegreeMagnacumLaudein1990andiscurrentlytheChiefMedicalOfficerforBodyLogicMD.ShepracticesAnti-AgingandFunctionalMedicineinGlastonbury,CT,lecturesthroughouttheUnitedStatesandistheauthorofthebook,HormoneHarmony.

Sahar Z. Swidan, Pharm.D., BCPS,isaboardcertifiedpharmacotherapyspecialistworkinginthefieldofchronicpainmanagement.SheisalsotheClinicalPharmacySpecialistontheinpatientHead-PainUnitatChelseaComm.Hospital,andisaClinicalAssociateProfessorofPharmacyattheUniversityofMichigan.SheisthePresident&CEOofbothPharmacySolutionsandNeuroPharmacologyConsultants,Inc.inAnnArbor,Michigan.

Eldred Taylor, M.D.,isaboard-certifiedobstetrician/gynecologist,DirectorofIntegrativeMedicineatDeKalbMedicalCenterinDecatur,Georgia,andanAssistantClinicalProfessoratEmoryUniversitySchoolofMedicine,andco-authorofAreYourHormonesMakingYouSick?

Filomena Trindade, M.D., MPH,practicesFunctionalMedicineinCapitola,CA,isagraduateoftheFellowshipinAnti-AgingandRegenerativeMedicineandteachesattheInstituteofFunctionalMedicine(IFM).SheiscurrentlyveryactiveindevelopingteachingprogramsinAnti-AgingandFunctionalMedicine.

Catherine Willner, M.D.,isChairoftheAmericanAcademyofNeurologyPainSection’sScientificCommittee.SheiscertifiedbytheAmericanBoardofPsychiatryandNeurology.Dr.WillnerhaspublishedseveralstudiesinthefieldofNeurologyandPainManagement.ShepracticesNeurology.

James L. Wilson, N.D., D.C., Ph.D., authorofAdrenalFatigue:The21stCenturyStressSyndrome,DirectorofResearchatImmunogenicsCompanyofAmericainTucson,AZ,andPresidentofFutureFormulationsinTucson,AZ.

David T. Zava, Ph.D.,PresidentandDirectorofZRTLaboratoryinBeaverton,OR,andco-authorofWhatYourDoctorMayNotTellYouAboutBreastCancerisaresearchscientist.Hisresearchisinthefieldofbasichormonalregulationofbreastcancerandthesymptoms,signs,syndromesanddiseasesofWesternsociety.

Faculty(continued)