Vaibhav Kumar MauryaPhD Research Fellow

NIFTEM

Haryana, India

study of slowing down or reversingthe processes of aging to extend boththe maximum and average lifespan

•Life extension is a controversial topic due to fear

of overpopulation and possible effects on society

•Biogerontologist Aubrey De Grey counters the

overpopulation critique by pointing out that the

therapy could postpone or eliminate menopause,

allowing women to space out their pregnancies over

more years and thus decreasing the yearly population

growth rate.Continued------

Moreover, the philosopher and futurist Max More

contends that, given current and projected global

fertility rates, “human life extension” would be

unlikely to contribute to overpopulation.

A research poll(2013) in the United States found that

38% of Americans would want life extension

treatments, and 56% would reject it. However it also

found that only 4 percent consider an "ideal lifespan"

to be more than 120 years.

•The longest a human has ever been

proven to live is 122 years, the case

of Jeanne Calment who was born in 1875

and died in 1997.

• In case of wild mouse, Maximum

lifespan commonly used as a model in

research on aging, is about three years.Continued---

• Genetic differences between humans

and mice that may account for these

different aging rates include differences

in efficiency of DNA

repair, antioxidant defences, energy

metabolism, and recycling mechanisms

such as autophagy

Autophagy : a normal physiological process in the body that deals with destruction of cells in the body. It maintains

homeostasis or normal functioning by protein degradation and turnover of the destroyed cell organelles for new cell

formation.

Average lifespan in a population is lowered by:

- Infants and child mortality, which are frequently linked

to infectious diseases or nutrition problems.

-Later in life, vulnerability to accidents and Age related

chronic disease; cancer or cardiovascular disease play an

increasing role in mortality.

Extension of expected lifespan can often be

achieved by access to improved medical

care, vaccinations, good diet, exercise and

avoidance of hazards such as smoking.

Much life extension research focuses on

nutrition—diets or supplements—as a means to

extend lifespan.

Extension of expected lifespan can often be

achieved by access to improved medical

care, vaccinations, good diet, exercise and

avoidance of hazards such as smoking.

Much life extension research focuses on

nutrition—diets or supplements—as a means to

extend lifespan.

•Anti-aging drugs/ Products

• Nanotechnology

• Cloning and body part replacement

Anti-aging drugs/ Products

# There are a number of drugs intended to slow the aging

process currently being researched.

Research by Sobh and Martin (2011) suggests that people buy anti-

aging products to obtain a hoped-for self (e.g., keeping a youthful

skin) or to avoid a feared-self (e.g., looking old).

Anti-aging drugs/ Products

Anti-aging drugs/ Products

Anti-aging drugs/ Products

•Nanotechnology

Future advances in nanomedicine could give rise to life extension

through the repair of many processes thought to be responsible for

aging.

K. Eric Drexler, one of the founders of nanotechnology, postulated

cell repair machines, including ones operating within cells and

utilizing as yet hypothetical molecular computers.

Raymond Kurzweil, a futurist and transhumanist, stated in his

book The Singularity Is Near that he believes that advanced

medical nanorobotics could completely remedy the effects of aging

by 2030

Cloning and body part replacement

Some life extensionists suggest that therapeutic cloning and stem

cell research could one day provide a way to generate cells, body

parts, or even entire bodies (generally referred to as reproductive

cloning) that would be genetically identical to a prospective

patient.

THANK YOU

Give your opinion about lifeextension whether it is good or badfor society?

What are the Safety issue linkedwith the use of anti-aging creams ?