Exposure X 2: Use and Safety of Personal Care Products ...
Transcript of Exposure X 2: Use and Safety of Personal Care Products ...
![Page 1: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/1.jpg)
Exposure X 2: Use and Safety of Personal Care Products During Pregnancy
Miranda Jones Spratlen, MHS, PhDPostdoctoral Research Scientist
Columbia Center for Children’s Environmental HealthColumbia University Mailman School of Public Health
![Page 2: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/2.jpg)
Personal Care Product ChemicalsEndocrine Disruptors
PARABENS• Methyl-• Ethyl-• Butyl-• Propyl-
PHENOLS• BP3• Triclosan• DCPs
PHTHALATES
![Page 3: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/3.jpg)
Widespread Exposure: National Findings
Phthalates
Parabens
Triclosan
BP3
DCPs
![Page 4: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/4.jpg)
Does Product Use = Exposure?
Urin
e Ph
thal
ate
Leve
l
Parlett et al. J Expo Sci Environ Epidemiol. 2013 Mar;23(2):197-206
![Page 5: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/5.jpg)
The More You Use, The More You Get: DoseParabens and Lotion Use
Sandanger et al. J Expo Sci Environ Epidemiol. 2011 Nov-Dec;21(6):595-600
Conc
entr
atio
n in
Urin
e
% of Body Lotioned
![Page 6: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/6.jpg)
Number of Products Used
Conc
entr
atio
n in
Urin
e
The More You Use, The More You Get: # of Products
![Page 7: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/7.jpg)
Exposure X 2: Product Use During Pregnancy
• Phthalates, Parabens and Phenols pass from mother to fetus through the placenta
• Fetus is particularly vulnerable and exposures may have long lasting effects
• Fetal exposure has been associated with:• Behavioral Problems• Altered Neurological Development• Endocrine Disruption• Asthma• Allergies• Altered Reproductive Development• Preterm Birth• Obesity/Cardiovascular Outcomes
![Page 8: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/8.jpg)
Overall Cohort• Enrolled 727 maternal-child pairs living in Northern
Manhattan or the South Bronx• African American and Dominican
Phthalate / Paraben Study• Questionnaire during pregnancy: 7 product categories
(deodorant, perfume, hair spray, hair gel, nail polish/polish remover, liquid soap/body wash, lotion/mist)
• Chemicals measured in mother’s urine during pregnancy (between May 2003 and July 2006)• Phthalates (n=435)• Parabens/Phenols (n=375)
Columbia Center for Children’s Environmental Health (CCCEH)
Cowell et al.
![Page 9: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/9.jpg)
Results: CCCEH vs. NationalPhthalates
![Page 10: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/10.jpg)
Results: CCCEH vs. NationalParabens Phenols
![Page 11: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/11.jpg)
Previous Findings: Phthalates
Phthalates
Just et al. J Expo Sci Environ Epidemiol. 2010 Nov;20(7):625-33
Phthalates
![Page 12: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/12.jpg)
New Findings: Parabens and Phenols
![Page 13: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/13.jpg)
New Findings: Parabens and Phenols
Methyl-Parabens
![Page 14: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/14.jpg)
How Can We Protect Ourselves?
![Page 15: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/15.jpg)
How Can We Protect Ourselves?
![Page 16: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/16.jpg)
Make the Right Choice!
HERMOSA Intervention Study• 100 Mexican American girls aged 14-
18 from Northern California• Intervention – Replacement Products
• Ingredient lists did not include triclosan, BP-3/oxybenzone, or any parabens
• Avoided products containing parfum or fragrance unless they were specifically labeled as “phthalate-free”
• Products used for 3 days-27.4
-11.3 -0.5
-43.9
47.2
101.7
-45.4-35.7 -36
Change in Chemicals Over Intervention Period
MEP MnBP MiBP MPB EPB BPB PPB Triclosan BP3Harley. Environ Health Perspect. 2016 Oct; 124(10): 1600–1607
![Page 17: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/17.jpg)
Make the Right Choice!
![Page 18: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/18.jpg)
Make the Right Choice!
VS.
![Page 19: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/19.jpg)
VS.
Make the Right Choice!
Methyl- and Propyl- Parabens
“Fragrance” = Phthalates
No Parabens
No Fragrance
![Page 20: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/20.jpg)
![Page 21: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/21.jpg)
![Page 22: Exposure X 2: Use and Safety of Personal Care Products ...](https://reader031.fdocuments.in/reader031/viewer/2022013000/61c973be3a8f7a1417219dab/html5/thumbnails/22.jpg)
Thank You!Acknowledgements
Dr. Julie Herbstman Dr. Ricky Perera Dr. Pam Factor-Litvak Dr. Robin Whyatt Kaila Boyer