Evidence-based Diagnosis in Medicine
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Transcript of Evidence-based Diagnosis in Medicine
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Diagnostics
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Using an online dating analogy
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Likey or no likey: process. Show one ‘hottie’, one ‘nottie’
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Ultimately, they may be ‘hot’ or they may be ‘not hot’ when you actually meet them – more pics
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2x2 table for Tinder
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What are you interested in? PPV and NPV
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But is that all you want to know?
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Coin toss analogy in low/high prevalence cohorts (bunnyburners.com and richmusclyheroes.com)
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Sensitivity and specificity: What God knows
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Pooling both perspectives: likelihood ratios
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Bayesian theory in practice
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ROC curves: let’s say that (instead of swiping yes or no) you rate the profiles out of 100
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Where do you put the cut-off? Examples
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ROC curve: show and explain
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Talk about AUC. Advantages (global measure)
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Disadvantages of AUC: show odd shaped ROC curve
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Where do you set the cut-off? Show
• Also, what do you do next? Validate in another cohort as performance calibrated to yours
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Summary
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