Enzymes! A special type of protein…??? In order for a protein to work at its SPECIFIC JOB, it must...
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Transcript of Enzymes! A special type of protein…??? In order for a protein to work at its SPECIFIC JOB, it must...
Enzymes!
Why do you think we can compare it to
this?
• A special type of protein…???• In order for a protein to work
at its SPECIFIC JOB, it must have….???
• Because an enzyme is a protein, it MUST have….???
• Can any key unlock the door to your house???
• Can any substrate/reactant fit into a specific enzyme?
• How many different enzymes do we have???
ENZYMES!!!
ENZYMES!!!• Proteins• Biological catalysts that
speed up the rate of chemical reactions
• They help make products faster!
• Never used up!• “Matchmaker”
Enzymes in Action
• Enzymes speed up chemical reactions that take place in cells
• They DECREASE ACTIVATION ENRGY– The energy needed to
get the reaction started (or energy needed to start making product)
Catal-ASE is an enzyme that helps
break up hydrogen peroxide
Proteins: Enzymes
• What is a chemical reaction?• Do they happen on their own?– If we stare at the piece of paper, are we going to
be able to make the oxygen molecules in the air collide with the cellulose in the paper?
– What do we need to do?• What are reactants?• What are products?
Factors that Effect the Rate of Reactions
• Temperature– Hot
• Breaks bonds that give proteins its tertiary structure DENATURES
– Cold• Slow down chemical reaction (formation of enzyme
substrate complex)
• pH– Acids and bases produce OH- and H+ ions
• too many ions are present, the enzyme may be denatured (twisted and pulled so out of shape that it can no longer function)
• Inhibitors– Non-competitive
• react with portions of the active site, changing of its shape
• Allosteric Inhibitors– Change shape of the enzyme– Attach to regulatory site (not active site) and change the
shape of the entire enzyme (specifically the active site)
– Competitive• look like substrate, bind to active site, but do not make
the intended product
Examples of endothermic reactions:Melting of ice absorbs energy Dissolving ammonium nitrate in water( the essence of commercial cold packs) PHOTOSYNTHESIS
Examples of exothermic reactions:Digestion of food releases energy (CELL RESPIRATION)All combustion reactions (fires) C + O2 CO2 + EAdding an alkali metal to water 2 Na + 2 H2O 2 NaOH + H2 + E
Condensation of water Explosion of bombs
Endothermic Reactionsthe reactants have less potential energy than do the products. Energy must be input in order to raise the particles up to the higher energy level.Energy + A + B --> AB
Exothermic Reactionsthe reactants have more potential energy than the products have. The extra energy is released to the surroundings. A + B --> AB + Energy
Enzymes• Enzyme– Catalyst
• Anything that speeds up the rate of a reaction by lowering the ACTIVATION ENERGY– Activ. E: energy required for a chem.
Rxn to start making products– used to regulate the rate (speed) of chemical
reactions– Protein that helps speed up a reaction that occurs
in a biological system– Name of enzymes end in –ASE
• all enzymes are proteins, but not all proteins are enzymes
• each chemical reaction in an organism requires its own specific enzyme
• enzymes are never changed by their reactions!
SubstrateMolecule/compound that attaches to enzyme
Active SiteSpecific location on enzyme for substrate to attachWhere the enzymatic reaction occurs
Enzyme-substrate complexWhen substrate binds to active site of enzyme
Productsmolecules produced at the end of an
enzymatic reaction
• Acetylcholinesterase– catalyzes the breakdown of the neurotransmitter
acetylcholine at several types of synapses as well as at the neuromuscular junction — the specialized synapse that triggers the contraction of skeletal muscle.
– One molecule of acetylcholinesterase breaks down 25,000 molecules of acetylcholine each second
– makes possible the rapid "resetting" of the synapse for transmission of another nerve impulse.
Lock and Key Model
Class work! Label Each box!
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3.
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2.
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Class Work!Label
Boxes!
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