Emollient purgatives

of 15 /15

Transcript of Emollient purgatives

Emollient Purgatives

• Commonly known as “stool softeners”,

act without being changed and simply aid expulsion by softening(docusate) and lubricating(liquid paraffin).

• one that promotes softening of the stool and facilitates passage of the feces through the intestines by its lubricant effect.


LUBRICANTS: Mineral oil

(Liquid Paraffin)


• Common docusate salt is:

-dioctyl sodium sulphosuccinate


• Mechanism of Action:

-They are anionic detergents.

-They lower the surface tension of the stool

-Hence, cause the accumulation of fluid and fatty substance and thus soften the stools.


• These agents act within 1-3 days

• Route of Administration:

-orally OR as a retention enema

Jgn masukkan gmbr ubat. Dr ramesh x bg. Sbbmcm utk commercialize.

Liquid Paraffin

• It is a mineral oil

• Mechanism of Action:- Penetrates and soften the stool in 2-3 days.- Also has lubricant effect, and thus helps in smooth defaecation.

• Route of Administration: -orally

**Preferred laxative in patients with cardiac disease, because it prevent straining during defaecation.


• Disadvantages:

a) very unpleasant to swallow because of oily consistency.

b) While swallowing, it may trickle into lungs causing lipid pneumonia.

c) Carries away fat soluble vitamins with it into the stools; deficiency may occur on chronic use.

d) Leakage of the oil pass anal sphincter may embarrass.

e) May interfere with healing in the anorectal region.

Jgn masukkan gmbr ubat. Dr ramesh x bg. Sbb mcm utk commercialize.

Docusates and liquid paraffin should not be combined as it increases the absorption of liquid paraffin.


• Emollient purgatives are both stool softener and lubricants.

• Division:

– Docusates

– Liquid paraffin


• Pharmacology Prep Manual for Undergraduates, Elsevier, Tara V Shanbhag.

Thank You