Emerging Oncogenic Viruses Programme

Wednesday 30 May 2012

Arrival of participants

Accommodation at the Hotel dei Bizantini and Registration

19:00-24:00

Opening ceremony and Dinner at Cantina Produttori Vini-Museo della Civiltà del Vino Primitivo (transport by bus)

19:00-19:15 Welcome Address

Dr Christopher Wild, IARC Director

19:15-19:45 Opening lecture “History and Perspectives of Tumor Virology”

Professor Harald zur Hausen, Nobel Prize in Medicine 2008

20:00-24:00 Dinner

Thursday 31 May 2012

08:00-09:00 Registration

Session 1

09:00-13:00

Epidemiology I

Chaired by Ethel-Michele De Villiers and Robert Garcea

09:00-09:25

[O1]

Risk of cancers in HIV-infected people and organ transplant-recipients

Silvia FRANCESCHI

(France)

09:25-9:50

[O2]

HPV markers in cancers of the upper aerodigestive tract

Michael PAWLITA

(Germany)

09:50-10:15

[O3]

Cutaneous HPV Type Distribution in Pathologically Confirmed External Genital Lesions (EGLs): The HIM Study

Anna GIULIANO

(USA)

10:15-10:30

[O4]

Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors

Mauro TOGNON

(Italy)

10:30-10:45

[O5]

Merkel Cell polyomavirus in gastro-intestinal neuroendocrine tumors

Massimo BARBERIS

(Italy)

10:45-11:00

[O6]

Prospective serological study of the new cutaneous polyomaviruses in immuno-suppressed renal transplant recipients

Els VAN DER MEIJDEN

(The Netherlands)

11:00-11:30 Coffee break

11:30-11:55

[O7]

Neutralization serotyping of BK polyoma-virus infection in kidney transplant recipients

Christopher BUCK

(USA)

11:55-12:20

[O8]

Epidemiology of MCPyV, HPyV6, HPyV7, HPyV9 and TSPyV polyomaviruses in humans and identification of cross-reactivity

Pierre COURSAGET

(France)

12:20-12:45

[O9]

A prospective study of the natural history of cutaneous human papillomaviruses and polyomaviruses in healthy men

Dana ROLLISON

(USA)

12:45-13:00

[O10]

Prognostic value of antibodies against MCPyV VLPs and MCPyV T-antigen, and vitamin D levels in Merkel cell carcinoma patients

Antoine TOUZÉ

(France)

13:00-14:30 Lunch

Session 2

14:30-18:10

Immunology

Chaired by Martin Kast and Raphael Viscidi

14:30-14:55

[O11]

Reversal of HPV-mediated suppression of Langerhans cell function with the TLR3 agonist Poly-ICR

W Martin KAST

(USA)

14:55-15:20

[O12]

Oncoviruses and innate immunity: the inflammasome response in the human liver and its role against HBV infection

Uzma HASAN

(France)

15:20-15:35

[O13]

The Large T antigen of Merkel Cell Polyoma virus down regulates human Toll-Like Receptor 9 Promoter

Naveed SHAHZAD

(France)

15:35-15:50

[O14]

MHC class I expression in HPV positive and negative tonsillar squamous cell carcinoma in correlation to clinical outcome

Torbjörn RAMQVIST

(Sweden)

15:50-16:05

[O15]

New perspectives of immunotherapy in HPV-associated head and neck cancers

Aldo VENUTI

(Italy)

16:05-16:35 Coffee Break

16:35-17:00

[O16]

Antibody dependent cellular cytotoxicity (ADCC) epitopes in human papilloma-virus type 16 E2 protein

Raphael VISCIDI

(USA)

17:00-17:25

[O17]

Passive protection of mice against gential HPV infection independently of FcRn using L2-specific monoclonal antibody

Richard RODEN

(USA)

17:25-17:40

[O18]

Efficacy of a second-generation broad-spectrum RG1-VLP HPV vaccine

Christina SCHELLENBACHER

(Austria)

17:40-17-55

[O19]

Development of AAV vectors for vaccination against HPV

Anna SACHER

(Germany)

17:55-18:10

[O20]

Natural variants in the major neutralizing epitope of human papillomavirus minor capsid protein L2

Hanna SEITZ

(Germany)

18:15-19:15 Poster Session

20:00 Dinner at Ristorante Reggia Domizia

(transport by bus)

Friday 1 June 2012

Session 3

08:30-13:05

Virus-host interaction I

Chaired by Alison McBride and Paul Lambert

08:30-08:55

[O21]

Distinct contributions of ATM and ATR to BK polyomavirus infection

Michael IMPERIALE

(USA)

08:55-09:20

[O22]

Nuclear virus factories in polyomavirus-infected cells

Robert GARCEA

(USA)

09:20-09:45

[O23]

Structural biology of polyomavirus host-cell attachment strategies

Thilo STEHLE

(Germany)

09:45-10:00

[O24]

Pseudoviruses and VP1 pentamers as surrogates to study infectious entry of human polyomaviruses

Walter ATWOOD

(USA)

10:00-10:25

[O25]

Human papillomavirus entry into host cells depends on delivery of the viral genome into the nucleus by nuclear envelope breakdown

Mario SCHELHAAS

(Germany)

10:25-10:55 Coffee Break

10:55-11:20

[O26]

Sequential engagement of multiple heparan sulfate binding sites during infectious entry of human papilloma-virus type 16

Martin SAPP

(USA)

11:20-11:45

[O27]

Potential papillomavirus virion/host-species specific interactions

Patricia DAY

(USA)

11:45-12:10

[O28]

Human papillomaviruses use a novel Trojan Horse approach for gaining entrance to human keratinocytes to initiate infection

Michelle OZBUN

(USA)

12:10-12:35

[O29]

A sequence-specific interaction with sulfated polysaccharides triggers a structural change in Human Papilloma-virus type 16 independently of a glycosaminoglycan protein

Carla CERQUEIRA

(Germany)

12:35-12:50

[O30]

The effect of HIV protease inhibitors on HPV16 titers and infectivity: comparison of cervical and oral tissue

Craig MEYERS

(USA)

12:50-13:05

[O31]

Beta papillomavirus replication in hair follicles provides a model for their reactivation in EV patients and organ transplant recipients

Cinzia BORGOGNA

(Italy)

13: 05-14:30 Lunch

Session 4

14:30-18:30

Cellular transformation I

Chaired by Denise Galloway and Mike Imperiale

14:30-14:55

[O32]

Interpreting cancer genomes using systematic host perturbations by tumor virus proteins

James DECAPRIO

(USA)

14:55-15:20

[O33]

Beta Human Papillomavirus 5 and 8 E6 Expression Attenuates UV Damage Signaling by Impairing ATR Activation

Denise GALLOWAY

(USA)

15:20-15:45

[O34]

HPV8-E6 inhibits transcription of the PDZ-protein Syntenin-2

Herbert PFISTER

(Germany)

15:45-16:10

[O35]

Tranforming properties of E6 and E7 oncoproteins from the genus beta human papillomavirus types

Rosita ACCARDI

(France)

16:10-16:25

[O36]

Effect of HPV16 E6 and E7 expression on multipotent epithelial progenitors

Katerina STRATI

(Cyprus)

16:25-16:55 Coffee Break

16:55-17:20

[O37]

Mechanisms regulating differentiation-dependent HPV genome amplification and late gene expression

Laimonis LAIMINS

(USA)

17:20-17:45

[O38]

HPV-associated cancers: who is the driver and how does she/he act?

Paul LAMBERT

(USA)

17:45-18:00

[O39]

Regulation of cellular microRNAs by the human papillomavirus Type 16 E6 oncogene

Saleem KHAN

(USA)

18:00-18:15

[O40]

MicroRNA profiling in E6/E7 HPV-transformed human keratinocytes

Vincenza CHIANTORE

(Italy)

18:15-18:30

[O41]

Elucidating the transforming potential of MCPyV T-Antigens

Nicole FISCHER

(Germany)

18:30-19:30 Poster Session

20:30 Dinner

Saturday 2 June 2012

Session 5

08:30-12:00

Epidemiology II

Chaired by Anna Giuliano and Michael Pawlita

08:30-08:55

[O42]

Further clues to the mystery of TT viruses

Ethel-Michele DE VILLIERS

(Germany)

08:55-09:20

[O43]

The trichodysplasia spinulosa-associated polyomavirus (TSPyV); epidemiology and pathogenicity

Mariet FELTKAMP

(The Netherlands)

09:20-09:45

[O44]

Oral HPV prevalence in young men and women is similar, yet higher in women with genital HPV, but less abundant than in patients with oropharynx cancer

Tina DALIANIS

(Sweden)

09:45-10:00

[O45]

Human papillomaviruses and TP53 mutation status in oropharyngeal squamous cell carcinoma

Maria Lina TORNESELLO

(Italy)

10:00-10:15

[O46]

Molecular evidence for transforming activity of established and probable/ possible high-risk human papillomavirus types in cervical cancer

Gordana HALEC

(Germany)

10:15-10:30

[O47]

Case-control study of genus-beta human papillomaviruses in plucked eyebrow hairs and squamous cell carcinoma of the skin

Michelle IANNACONE

(France)

10:30-11:00 Coffee Break

11:00-11:15

[O48]

No Evidence of Human beta papilloma-

virus (HPV) infection in skin tumours from chronic lymphocytic leukemia patients

Alberto PERETTI

(Italy)

11:15-11:30

[O49]

Search for viruses causing human cancer: a new genomic approach

Vincent FERRETTI

(Canada)

11:30-11:45

[O50]

EBV, HPV and MMTV as multiple viruses in breast cancer

Noel WHITAKER

(Australia)

11:45-12:00

[O51]

Epstein-Barr Virus, Human Polyoma-viruses and Non-Hodgkin Lymphoid Neoplasms

Lauren R TERAS

(USA)

12:00-13:30 Lunch

Session 6

13:30-16:35

Virus-host interaction II

Chaired by Susanna Chiocca and Thomas Schulz

13:30-13:55

[O52]

Regulation of the human papillomavirus life cycle by host cell protein kinases

Sally ROBERTS

(UK)

13:55-14:20

[O53]

Replication and persistence of papillomavirus genomes by association with host chromatin

Alison MCBRIDE

(USA)

14:20-14:45

[O54]

Discovery and function of microRNAs in small DNA Viruses

Christopher SULLIVAN

(USA)

14:45-15:10

[O55]

Mutations in the GM1 binding site of SV40 VP1 alter receptor usage and cell tropism

Daniel DIMAIO

(USA)

15:10-15-25

[O56]

How structures of papillomavirus E6 and E7 oncoproteins improve our under-standing of their evolution

Sebastian CHARBONNIER

(France)

15:25-15:55 Coffee Break

15:55-16:20

[O57]

Infectious canine papillomavirus production and tropism

Hang YUAN

(USA)

16:20-16:35

[O58]

Examining the viral and cellular micro-RNA targetome during EBV infection

Rebecca SKALSKY

(USA)

Session 7

16:40-18:20

Cellular transformation II

Chaired by Sally Roberts and Daniel DiMaio

16:40-17:05

[O59]

Oncogene-induced Senescence and the pRB signaling network

Karl MUNGER

(USA)

17:05-17:30

[O60]

Cellular targets of cutaneous HPV types and their role in skin cancer

Ingo NINDL

(Germany)

17:30-17:55

[O61]

How does SV40 DNA replication exploit host DNA damage signaling?

Ellen FANNING

(USA)

17:55-18:20

[O62]

Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression

Thomas SCHULZ

(Germany)

20:00 Social Dinner at Masseria Li Surìì

(transport by bus)

Sunday 3 June 2012

Departure – Shuttles to airport

…/…

Poster Sessions

Thursday 31 May 2012, 18:15-19:15

Friday 1 June 2012, 18:30-19:30

P1 Antibodies in single-chain format against the E6 and E7 oncoproteins of Human Papilloma-viruses type 16: biological effects in vitro and in vivo

Luisa ACCARDI (Italy)

P2 Conservation and evolution of the E3 ubiquitin ligase assembled by the adenoviral proteins E4orf6 and E1B55K

Paola BLANCHETTE (Canada)

P3 Comparative analysis of transforming properties of E6 and E7 of different beta HPV types

Iris CORNET (France)

P4 Oxidative stress and cell adaptation to oxidative stress are two distinct features of HPV 16 carcinogenesis

Federico DE MARCO (Italy)

P5 hScrib contributes to the regulation of HPV-18 E6 expression

Christian KRANJEC (Italy)

P6 Role of IkappaB kinase beta in cutaneous human papillomavirus type 38–mediated transformation

Djamel SAIDJ (France)

P7 In vitro RT-PCR infectivity assays using native cutaneous and mucosal HPV virions

Saeed SHAFTI-KERAMAT (Austria)

P8 Regulation of tumour suppressor DOK1 expression in Burkitt’s lymphoma: role of Epstein Barr virus

Maha SIOUDA (France)

P9 Structural analysis of receptor engagement by the Trichodysplasia Spinulosa- associated Polyomavirus

Luisa J. STRÖH (Germany)

P10 HPV E6 oncoproteins from high and low risk types associate with the proteasome independently of E6AP

Vjekoslav TOMAIC (Italy)

P11 The role of HPV16 variants in the development of cervical cancer worldwide

Iris CORNET (France)

P12 Mucosal and cutaneous human papilloma-viruses detected in raw sewages collected throughout Italy

Luisa ACCARDI (Italy)

P13 Human papillomavirus prevalence and p16INK4a overexpression in Head and Neck squamous cell carcinoma

Maria BENEVOLO (Italy)

P14 The distribution of JC virus receptors in human tissue

Sheila HALEY (USA)

P15 Oncogenic viruses and cancers in southern Africa

Danuta KIELKOWSKI (South Africa)

P16 The detection of novel polyomaviruses HPyV6, HPyV7 and MCPyV in healthy and immuno-compromised individuals

Vojtech SROLLER (Czech Republic)

P17 HPVs manipulation of the SUMO pathway Domenico MATTOSCIO (Italy)

P18 Human papillomavirus type 38 E6 and E7 act as tumor promoter during skin chemical carcinogenesis

Daniele VIARISIO (Germany)