EBOLA VIRUS DISEASEEVD

KEY FACTSWHO Facts Sheet – Updated April 2014

Key Facts• Key facts• Ebola virus disease (EVD), formerly known as Ebola

haemorrhagic fever, is a severe, often fatal illness in humans.• EVD outbreaks have a case fatality rate of up to 90%.• EVD outbreaks occur primarily in remote villages in Central and

West Africa, near tropical rainforests.• The virus is transmitted to people from wild animals and

spreads in the human population through human-to-human transmission.

• Fruit bats of the Pteropodidae family are considered to be the natural host of the Ebola virus.

• Severely ill patients require intensive supportive care. No licensed specific treatment or vaccine is available for use in people or animals.

CryoEM of EBOV. (A) Low-magnification cryoEM images of purified EBOV. Protein density is black.

Bharat T A M et al. PNAS 2012;109:4275-4280©2012 by National Academy of Sciences

CryoET and 3D reconstruction of the EBOV NC from subtomogram averaging.

Bharat T A M et al. PNAS 2012;109:4275-4280

©2012 by National Academy of Sciences

Minimum assembly component of the EBOV NC. (A) CryoEM image of purified full-length EBOV NP. Protein density is black.

Bharat T A M et al. PNAS 2012;109:4275-4280

©2012 by National Academy of Sciences

Location of viral proteins in the EBOV NC. (A) 2D class averages of the NC from NP+VP40 VLPs. (B) 2D class averages of the NC from NP+VP24+VP35+VP40 VLPs. (C) 2D class

averages of the NC from EBOV virions.

Bharat T A M et al. PNAS 2012;109:4275-4280

©2012 by National Academy of Sciences

Steps involved in EBOV NC assembly.

Bharat T A M et al. PNAS 2012;109:4275-4280

©2012 by National Academy of Sciences