Dubravka Šipuš, 2nd year2013/2014

Mentor: A. Žmegač Horvat

Hemostasis – prevention of blood loss

Mechanisms:

1)Vascular constriction

2)Formation of a platelet plug

3)Formation of a blood clot

4)Growth of fibrous tissue

Fast process

Procoagulants and anticoagulants

Complex cascade of chemical reactions

Blood coagulation factors

Formation of prothrombin activator

Extrinsic pathway

Intrinsic pathway

Endothelial surface factors (smoothness, glycocalyx, thrombomodulin)

Antithrombin III - heparin cofactor

Coumarin (warfarin)

Citrate ion, oxalate

Vitamin K deficiency

Diseases of the liver

Hemophilia

Thrombocytopenia

Guyton, Hall: Textbook of Medical Physiology